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41495892 | Argonaute-mediated RNA editing selectively repairs point mutations. | RNA editing enzymatically modifies RNA molecules post-transcriptionally, enabling precise sequence alterations. Advantages include reversibility and temporal control without genomic DNA changes, allowing dynamic regulation of gene expression while preserving original genetic information. In this study, we characterized... |
41491643 | Photophysical and DNA-Binding Properties of Phenoxazine-Based Push-Pull Type Organic Chromophores: Insights From DFT, Molecular Docking, and Optical Studies. | In this work, we investigate the photophysical and DNA-binding characteristics of phenoxazine-based organic dyads comprising donor-acceptor configuration, with the goal of boosting their potential for biointeractive applications. The interaction of these dyes with calf thymus DNA was analyzed using UV spectroscopy, con... |
41491636 | Characterisation of a Novel Jumbo Lytic Aeromonas dhakensis Bacteriophage P19 and Its Endolysin. | Aeromonas dhakensis is an emerging multidrug-resistant (MDR) bacterial pathogen that presents significant threats to public health and aquaculture. This study reports the isolation and comprehensive characterisation of jumbo bacteriophage P19. It is a lytic phage with a long, contractile tail and is placed in the genus... |
41490602 | The Lysine Demethylase KDM4C Is an Oncogenic Driver and Regulates ERK Activity in KRAS-Mutant Pancreatic Ductal Adenocarcinoma. | Deregulation of proteins involved in chromatin regulation is common in pancreatic ductal adenocarcinoma (PDAC). Lysine demethylase 4C (KDM4C) is one of the chromatin-modifying proteins frequently overexpressed across multiple solid cancers and is linked to chromatin instability, increased cell proliferation, and enhanc... |
41489476 | Nanomedicine applications for the treatment of Staphylococcus aureus infections. | Staphylococcus aureus is a Gram-positive bacterium capable of infecting multiple types of cells, organs, and tissues in the human body. Treatment can become highly challenging, especially in the case of intracellular infections and upon biofilm formation. Additionally, this pathogen has developed several antimicrobial ... |
41489110 | Improving Energy and Molecular Properties by Convergence of the One-Particle Reduced Density Matrix in Variational Quantum Eigensolvers (VQE). | The variational quantum eigensolver (VQE) is a relevant method for simulating molecular systems on near-term quantum computers. While its primary application is the estimation of ground-state energies, VQE also produces the one-particle reduced density matrix (1-RDM), from which other relevant molecular properties can ... |
41485384 | A novel Mn-MOF-HBT based fluorescent sensor for selective and sensitive detection of acrylamide in food products. | Acrylamide (AA) is a toxic and potentially carcinogenic compound formed in carbohydrate-rich foods subjected to high-temperature processes such as frying, baking, and roasting. Its adverse health effects, including neurotoxicity and carcinogenicity, have raised serious concerns regarding food safety. In this study, we ... |
41484095 | Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustion. | T cell exhaustion is a prevalent phenomenon in chronic infections and tumor microenvironments, severely compromising the effectiveness of antitumor and antiviral immunity. In recent years, there has been significant progress in understanding the underlying mechanisms of T cell exhaustion, including external factors and... |
41483860 | Design, synthesis and biological evaluation of macrocyclic NTRK heterobifunctional degraders. | Aberrant NTRK gene fusions leading to constitutively activated NTRK proteins are a key driver for a range of adult and pediatric tumors. Small molecule NTRK inhibitors targeting the NTRK ATP site have shown success in the clinic resulting in two approved drugs. Unfortunately, resistance mutations have created the need ... |
41482694 | Development of Efficient Supramolecular Photostabilizer for Carotenoids and Retinoids: Analyses and Application Research. | <h4>Background</h4>Carotenoids and retinol are well known for their potent antioxidant and biological properties in pharmaceuticals, foods, and cosmetics. However, their poor photostability presents a significant challenge that cannot be effectively addressed through simple formulation strategies such as encapsulation.... |
41481792 | β-Cyclodextrin Inclusion Complex of d-Limonene: A Promising Biocompatible Formula for Enhanced Wound Healing-In Vitro and In Vivo Studies. | Wound healing, a complex multifactorial process, continues to pose a challenge, justifying the search for innovative therapeutic approaches to accelerate recovery. In this study, β-cyclodextrin-encapsulated d-limonene (βCD-d-limonene) was formulated and investigated as a promising strategy for wound management. The inc... |
41480781 | AutoLEI: A step towards automatic 3D ED data processing. | A user-friendly interface has been developed for XDS, enabling efficient real-time and batch processing of 3D ED data to accelerate structure determination. |
41479266 | Quantitative Analysis of Polymers by MALDI-TOF Mass Spectrometry: Correlation Between Signal Intensity and Arm Number. | The signal intensities of linear and star-shaped poly(L-lactides) (PLA) and poly (ethylene oxides) (PEO) were compared to determine the influence of the number of arms on the ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. In this study, a variety of blends were p... |
41479263 | MOF Composite Nanogel Printed Sensor for Tracking Glucose Consumption in Growing Cells and Uptake at the Cellular Level. | A simple one-step process to synthesize a metal-coordinated polymeric hydrogel composite for the preparation of an automated printed sensor is proposed. In this work, the chelation mode of benzene-1,4-dithiocarboxamide is used as a precursor to synthesize nickel (Ni) and molybdenum (Mo)-metal-organic framework (MOF) (N... |
41479203 | The Coordination Microenvironment Tailoring in 2D MOFs for Enhancing Photocatalytic Acetylene Semi-Hydrogenation. | The semi-hydrogenation of acetylene (C<sub>2</sub>H<sub>2</sub>) to ethylene (C<sub>2</sub>H<sub>4</sub>) by photocatalytic is a new and clean strategy for removal of C<sub>2</sub>H<sub>2</sub> impurities from raw C<sub>2</sub>H<sub>4</sub> to produce polymer-grade C<sub>2</sub>H<sub>4</sub>. In the state-of-the-art, m... |
41479176 | High-Pressure Synthesis of Antimony Nitride Sb<sub>3</sub>N<sub>5</sub> and Polynitride Sb<sub>2</sub>N<sub>8</sub> Featuring Single-Bonded N<sub>8</sub> <sup>10-</sup> Chains. | High-pressure high-temperature synthesis in laser-heated diamond anvil cells provides a direct pathway to stabilize polymeric and oligomeric nitrogen units, often inaccessible under ambient conditions due to the stability of the N<sub>2</sub> molecule. Here we report the high-pressure reactivity of antimony with molecu... |
41479168 | A Consistent Approach to One Coordinate Pnictide Moieties M≡Pn<sup>-</sup> Using PnH<sub>2</sub> <sup>-</sup> Salts (M = Zr, Ti; Pn = P, As, Sb). | Establishing a congruent approach to delivering a pnictide atom (Pn<sup>3-</sup> = P, As, and Sb) to transition metal ions is a challenge, especially for the heavier congeners As and Sb, and when varying the transition metal. We showcase here a convenient route to molecular forms of one coordinate stibide ligands bound... |
41478998 | Descriptor-Driven Designed FeCoNiMoV High-Entropy Alloys for Exceptional Oxygen Evolution Activity. | The oxygen evolution reaction (OER) generally relies on scarce noble electrocatalysts with low activity and stability. High-entropy alloys (HEAs) offer compositional flexibility to overcome these limitations; however, rational design principles and scalable synthesis methods are still lacking. Herein, we propose a stra... |
41478732 | Catalytic DNA Circuit-Driven Surface-Enhanced Raman Scattering Amplification Enables Multiplexed Live-Cell Imaging of Receptor Crosstalk and Feedback Regulation. | The dysregulation of the hepatocyte growth factor/c-mesenchymal-epithelial transition factor (HGF/c-Met) signaling pathway stimulates an invasive epithelial-mesenchymal transition (EMT) and establishes a pathogenic feedback loop by stimulating vascular endothelial growth factor (VEGF) secretion, creating an urgent need... |
41477872 | Engineered anchoring aptamers induce relocalization and functional inactivation of transcription factors. | Proper nucleocytoplasmic distribution of transcription factors (TFs) is crucial for cellular homeostasis. Mislocalization of TFs contributes to cancers, making TF relocalization a promising anticancer therapeutic strategy. We engineered anchoring aptamers as a platform for relocalizing TFs. Anchoring aptamers are heter... |
41477862 | Dynamic adaptive coassembled sericin protein orchestrating stem cell development for nucleus pulposus regeneration. | The zonal structure of natural extracellular matrix (ECM) creates a dynamic microenvironment that regulates mechanical and biochemical signals to support stem cell development. Here, we engineered a dynamic adaptive protein gel by coassembling bioactive sericin with an amphiphilic tripeptide, forming a nucleus pulposus... |
41477853 | Biomimetic action-potential transmission via mechano-gated potassium channels assembled by quadruple hydrogen-bonded crown ethers. | Biological potassium channels exemplify nature's precision in ion discrimination, governing critical processes such as osmotic regulation and neuronal signaling. Developing artificial potassium channels with biological-level and dynamic selectivity is of fundamental importance for intelligent nanofluidic devices. Here,... |
41477845 | Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells. | Breast and other solid tumors respond poorly to immune therapy. Myeloid cells (MCs) such as macrophages contribute to resistance. Established clinical evidence links cholesterol to cancer outcomes, with MC function being regulated by cholesterol metabolism. We screened MC-expressed regulators of cholesterol homeostasis... |
41477834 | Nanopore profiling and structure determination of oligosaccharides by fragmentation. | Oligosaccharides, polymers of covalently linked monosaccharides, are essential biomolecules mediating diverse biological and physiological processes. Despite their critical roles, the structural complexity of many oligosaccharides poses a notable challenge for comprehensive characterization, limiting our understanding ... |
41477831 | LPS-induced structural reorganization and polymerization drive noncanonical inflammasome activation. | The noncanonical inflammasome, mediated by murine caspase-11 and its human orthologs caspase-4 and caspase-5, detects intracellular lipopolysaccharide (LPS) and triggers pyroptotic cell death. Upon LPS binding through their amino-terminal caspase activation and recruitment domains (CARDs), these inflammatory caspases o... |
41477823 | Autologous human iPSC-derived alveolus-on-chip reveals early pathological events of <i>Mycobacterium tuberculosis</i> infection. | Immunocompetent and experimentally accessible alveolar systems to study human respiratory diseases are lacking. Here, we developed a single-donor human induced pluripotent stem cell-derived lung-on-chip (iLoC) containing type II and I alveolar epithelial cells, vascular endothelial cells, and macrophages in a microflui... |
41477822 | Membrane microdomains are crucial for <i>Mycobacterium marinum</i> EsxA-dependent membrane damage, escape to the cytosol, and infection. | <i>Mycobacterium tuberculosis</i> disrupts the membrane of the <i>Mycobacterium</i>-containing vacuole (MCV) via its EsxA virulence factor, secreted via the ESX-1 system. We identified how pathogenic <i>Mycobacterium marinum</i> exploits host sterol-rich membrane microdomains to induce MCV damage during infection of <i... |
41477811 | Covalent Control of Excitonic Interactions in Perylenediimide Trimers: A Computational Study. | Covalently tethering chromophores is an emerging strategy to control the structure and function of supramolecular aggregates for organic electronic applications. In this study, we employ first-principles calculations to elucidate structure-property relationships in three perylenediimide (PDI) trimer systems: a noncoval... |
41477722 | Functionalized Pillar[6]arene Nanomembrane Probe for Ultrasensitive Sensing of Clinically Valuable 1-Methylnicotinamide in Mouse Urine. | Analyzing 1-methylnicotinamide (1-MNA), a nicotinamide metabolite implicated in metabolic disorders, in biological systems is challenging owing to its trace-level concentrations and matrix effects. Herein, we report an electrochemical sensor featuring a micropipette functionalized with charge-tunable nanomembranes cons... |
41476280 | Ultrafast Sulfur Redox Dynamics Enabled by a PPy@N-TiO<sub>2</sub> Z-Scheme Heterojunction Photoelectrode for Photo-Assisted Lithium-Sulfur Batteries. | Photo-assisted lithium-sulfur batteries (PALSBs) offer an eco-friendly solution to address the issue of sluggish reaction kinetics of conventional LSBs. However, designing an efficient photoelectrode for practical implementation remains a significant challenge. Herein, we construct a free-standing polymer-inorganic hyb... |
41476276 | High-Density 1D Ionic Wire Arrays for Osmotic Energy Conversion. | Osmotic energy, existing between the seawater and river water, is a renewable energy source, which can be directly converted into electricity by ion-exchange membranes (IEM). In traditional IEMs, the ion transport channels are formed by nanophase separation of hydrophilic ion carriers and hydrophobic segments. It is di... |
41476220 | Covalent organic framework-based electrochemical nanosensing: an emerging paradigm for early cancer diagnosis and longitudinal surveillance. | The management of cancer relies crucially on early diagnosis and personalized treatment. Real-time analysis of tumor markers within the tumor microenvironment via liquid biopsy opens potential pathways for effective cancer treatment and improved survival rates. Detecting low-abundance tumor markers in bodily fluids, pa... |
41476047 | RBFNN-Based PPy/GaN sensor array with wide dynamic range and sub-ppb detection for accurate ammonia identification in human exhaled breath. | Detecting ammonia (NH<sub>3</sub>) in human breath is vitally important for early warning and disease detection. Polymer composite nanomaterials, which serve as high-performance NH<sub>3</sub> gas sensors, have become a prominent research focus in this field. In this study, polypyrrole (PPy) and various gallium nitride... |
41474896 | Prediction of Clinical Features and Outcome of Leptospirosis associated AKI according to Acute Kidney Injury Net work Classification in a Tertiary Care Hospital of Bangladesh. | Acute kidney injury (AKI) is a common complication of leptospira infection. The changes in renal function during leptospira infection are related to prognosis and mortality of patients. The risk factors for developing AKI after leptospira infection include systemic and renal hemodynamic changes secondary to impaired re... |
41473977 | Is Counterpoise Method a Proper Procedure for Evaluating the Dispersion Energy? | The counterpoise (CP) method, widely used to evaluate the basis set superposition error (BSSE) inherent in the supermolecular approach, is critically examined in the study of noncovalent interaction between rare gas atoms. Potential energy curves for the rare gas dimers (He<sub>2</sub>, Ne<sub>2</sub>, and Ar<sub>2</su... |
41466363 | The Right Person, the Right Treatment, at the Right Time in Alzheimer's Disease: Insights From the 2025 Brain Aging Symposium. | On October 22nd, 2025, Brain Aging Symposium took place at Harvard Medical School bringing together leading researchers from academia and partner organizations to discuss recent advances in measuring and monitoring human brain aging trajectories, with a particular focus on Alzheimer's disease (AD). A central theme emer... |
41466198 | Temperature-relied defense: CsMYBs-CsHT9 modules activate N-feruloylputrescine biosynthesis against anthracnose in tea (Camellia sinensis). | Tea (Camellia sinensis), a globally significant economic crop, is severely affected by anthracnose disease, impacting both yield and quality. Our previous research identified N-feruloylputrescine (Fer-Put) as enhancing tea's disease resistance, with CsHT9 potentially crucial for Fer-Put biosynthesis. In this investigat... |
41457476 | Immunoinformatics-Based Multi-Epitope Vaccine Targeting Helicobacter Pylori. | <h4>Background</h4>The rising global incidence of Helicobacter pylori-related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address this public health challenge.<h4>Aims</h4>The aim of this st... |
41454556 | Optimizing Essential Oil Blends by Mixture Design Approaches for Enhanced Antimicrobial and Antioxidant Activity: A Review. | The growing interest in natural alternatives to synthetic additives has driven research into essential oils (EOs) for antimicrobial and antioxidant applications. Statistical mixture design approaches provide effective tools to optimize multi-component EO blends for enhanced bioactivity. This review presents an overview... |
41439727 | Milk Modulates the Gastrointestinal Stability of Tick-Borne Encephalitis Virus: Implications for Alimentary Transmission. | Tick-borne encephalitis virus (TBEV) can be transmitted alimentarily through contaminated dairy products, yet the mechanisms by which the virus survives the digestive tract remain poorly understood. In this study, we investigated the stability of TBEV in milk under simulated gastrointestinal conditions. While milk is k... |
41437844 | Risk Factor Analysis Based on Disease Severity: Rosacea Disease Management Strategies and Personalized Recommendations. | <h4>Background</h4>Rosacea is a common chronic inflammatory skin disease with complex causes and varied clinical manifestations. While risk factors for its onset have been studied, key factors associated with disease severity remain unclear. Identifying these factors is essential for optimizing management and treatment... |
41437782 | Evolutionary Balancing of Genetic Consequence and Innovation in Mammals Through Variable Number Tandem Repeats. | Understanding genomic function has historically relied on sequence conservation across evolutionary time. However, advances in genomics have revealed that functional innovations often arise from rapidly evolving, nonconserved elements that are frequently overlooked by conservation-based approaches. Among these, variabl... |
41432310 | Comparing Functional Consequences of Human iPSC-Microglia and Neural Stem Cell-Derived Extracellular Vesicles in Mitigating Cognitive Decline in Alzheimer's Disease. | Stem cell-derived extracellular vesicles (EVs) show promise as a therapeutic approach for neurodegenerative diseases, particularly Alzheimer's Disease (AD), where traditional regenerative interventions have achieved limited success. Our previous research demonstrated the neuroprotective benefits of human neural stem ce... |
41432269 | Two-conformer equilibrium of maltose-binding protein in the absence of ligand from residual dipolar coupling analysis. | Prior analyses found good agreement between numerous residual dipolar couplings (RDCs) measured in the apo-state of maltose binding protein (MBP) and its X-ray crystal structure. However, paramagnetic relaxation enhancement (PRE) measurements on the same system reported on the presence of a small population of partiall... |
41431842 | The 2026 Nucleic Acids Research database issue and the online molecular biology database collection. | The 2026 Nucleic Acids Research database issue has 182 papers from across biology and neighbouring fields. Eighty-four of these papers describe new databases, while 86 are updates on databases that have previously appeared here. Twelve more papers cover databases most recently published elsewhere. New nucleic acid data... |
41431443 | AutoLEI: An XDS-based pipeline with graphical user interface for automated real-time and offline batch 3D ED/microED data processing. | Three-dimensional electron diffraction (3D ED), also known as microcrystal electron diffraction (microED), is an emerging method for determining structures from submicron-sized crystals. With the development of rapid and convenient data collection protocols, acquiring dozens of datasets in a single 3D ED/microED sessio... |
41427743 | Hydrogen-deuterium exchange reveals catalytically linked protein flexibility in myoglobin-mediated intramolecular C(sp<sup>3</sup>)-H activation. | A comprehensive understanding of the biophysical parameters that dictate high catalytic efficiency in enzymes is essential for advancing both fundamental enzymology and its applications. Experimental evidence suggests that protein dynamics play a pivotal role in transiently shaping active site configurations, facilitat... |
41427733 | Dynamic interaction of the Yersinia pseudotuberculosis type three secretion system proteins LcrV and LcrG. | Yersinia pathogenicity is dependent on polarized translocation of effector proteins via the type III secretion system (T3SS). The tip complex situated on the needle structure of the T3SS is required for contact with the eukaryotic host membrane and is to an extent composed of pentameric LcrV. LcrV is a multifunctional ... |
41427678 | Interaction of Staphylococcus aureus di-iron Repair of Iron Centers protein with the iron-sulfur cluster assembly SUF system. | Repair of Iron Centers (RIC) proteins are present in several pathogens, including Staphylococcus aureus, contributing to resistance to nitroxidative stress and virulence. In this work, we investigated the molecular mechanisms by which S. aureus RIC facilitates iron mobilization, through structural analyses and function... |
41424857 | Erratum: Albumin-seeking dyes with adjustable assemblies <i>in situ</i> enable programmable imaging windows and targeting tumor imaging: Erratum. | [This corrects the article DOI: 10.7150/thno.92991.]. |
41424853 | Development of New IL-1R Antagonists with Improved Anti-inflammatory Efficacy. | <b>Background:</b> Anakinra, a recombinant human interleukin-1 receptor antagonist (hIL-1Ra), is a widely used anti-inflammatory biologic for conditions like rheumatoid arthritis and gout. However, its limited potency and dose-dependent side effects restrict broader therapeutic application, highlighting a need for more... |
41424855 | Functional material probes and advanced technologies in organ-on-a-chip characterization. | Organ-on-a-Chip (OoC) integrates advanced biomaterials, microfluidics, and cell biology to simulate organ structures and dynamic microenvironments, offering a vital platform for drug development and disease modeling. The miniature scale, structural precision, high biomimetic fidelity, and inherent dynamic complexity of... |
41424845 | Targeted nanoparticles for placenta-specific drug delivery in pregnant rhesus macaques. | <b>Rationale:</b> To reduce the risks associated with systemic drug administration in pregnancy and create new therapies for placental dysfunction, we have previously developed targeted liposomes capable of selective delivery of payloads to the placentas of pregnant mice. In this study, we assessed whether these liposo... |
41424852 | Hydrogel adhesives for upper gastrointestinal wound healing. | This review discusses the latest progress in hydrogel adhesives for upper gastrointestinal wound healing. The specific acidic environment of the upper gastrointestinal tract makes treating upper gastrointestinal wounds, especially gastric bleeding and perforation, quite challenging. Recent research on hydrogels in biom... |
41424843 | Cuproptosis-triggering nanomedicine boosts antitumor immunotherapy. | Cuproptosis, a copper-dependent programmed cell death triggered by mitochondrial copper accumulation and subsequent proteotoxic stress, has emerged as a promising strategy to enhance antitumor immunity. However, conventional cuproptosis inducers face critical limitations such as short blood circulation half-lives, dose... |
41424036 | Whole genome analysis of toxic Papilionidae butterflies utilizing aristolochic acid, Pachliopta aristolochiae, and Byasa alcinous. | Several species of toxic butterflies are known, including those from the Troidini tribe of the Papilionidae, which accumulate aristolochic acid from their host plants in Aristolochiae. However, the molecular mechanisms involved in utilizing aristolochic acid remain unknown. Toxic butterflies often exhibit warning colou... |
41416715 | Synergistic strategies for high production of Geobacillus stearothermophilus α-amylase in Bacillus subtilis. | Although the α-amylase (AmyS) from Geobacillus stearothermophilus exhibits high thermostability, its low enzymatic activity (44.36 ± 2.02 U/mL) severely hinders industrial applications. Given its strong protein secretion capability and GRAS (generally recognized as safe) status, this study employed Bacillus subtilis as... |
41416707 | Anisotropic diffraction of materials with fibre symmetry: application to chitin cuticle. | Understanding the structure-function relationships in anisotropic fibre-symmetric materials is critical for both biological insight and bioinspired design. We present a generalized analytical model for X-ray diffraction intensity from nanofibrillar materials with fibre symmetry, accommodating arbitrary diffraction ring... |
41414956 | Persistence of triazole fungicides in agricultural topsoil is driven by reduced bioaccessibility with aging. | Triazole fungicides are widely detected in agricultural soils, yet their long-term persistence remains poorly understood. We evaluated how sorption, bioaccessibility, and degradation change with aging under field conditions. Topsoil was collected over 2 years from four Danish fields with detailed spray records. Tebucon... |
41410510 | ASAS-NANP symposium: mathematical modeling in animal nutrition: contributions of mathematical modeling to life cycle assessment to support environmental sustainability of animal production. | Life cycle assessment (LCA) provides a standardized framework for evaluating the environmental impacts of animal production systems through its four key steps: 1) goal and scope definition, 2) inventory analysis, 3) impact assessment, and 4) interpretation. However, traditional approaches using surveys and experimental... |
41407659 | Processing of DNA Topoisomerase II-DNA-Protein Crosslinks Associated With Anticancer Drugs. | During cell division and gene expression, the DNA double-helical structure unwinds, thereby generating torsional stress. DNA topoisomerases are enzymes that relieve this stress. During this process, topoisomerases form temporary covalent bonds with the phosphate backbone of DNA, generating DNA strand breaks and relievi... |
41399365 | FGF-23 facilitates osteosarcoma metastasis by modulating the miR-4463/LOXL2 axis expression via the ERK, p38, and JNK signaling pathway. | Osteosarcoma is a highly malignant bone tumor affecting children and adolescents. Once metastasis occurs, the five-year survival rate drops to ~20%, emphasizing the need for new therapies. Fibroblast growth factor-23 (FGF-23), a bone-derived hormone, has been implicated in tumor progression, but its role in osteosarcom... |
41399232 | Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis. | The synaptonemal complex (SC), a hallmark of meiosis, is a zipper-like protein assembly that links homologous chromosomes to regulate their recombination and segregation. With its characteristic ladder-like structure bridging paired homologs, the SC possesses unique biochemical and biophysical properties that influence... |
41397944 | Energetics Decomposition of Sac7d:DNA Decrypts Amino Acids Role Without DNA Sequence Selectivity. | Sac7d is a 7 kDa protein belonging to the class of the small chromosomal proteins from archeon Sulfolobus acidocaldarius. Sac7d was discovered in 1974 in Yellowstone National Parks geysers, and studied extensively since then for its remarkable stability at large pH and temperature ranges. Sac7d binds to the DNA minor g... |
41392871 | Enhancing Bioavailability and Stability of Fat-Soluble Vitamins Through Interactions With Food Macromolecules: Modern Technological Approaches. | Fat-soluble vitamins (FSVs), including vitamins A, D, E, and K, are essential micronutrients but exhibit poor water solubility, high sensitivity to light, heat, and oxidation, and consequently low bioavailability, which limits their effective utilization in functional food and nutraceutical systems. Recent advances sho... |
41388905 | Multiple input-multiple output (MIMO) designs in two-component signalling systems of Mycobacterium tuberculosis. | Two-component systems (TCSs), the primary communication pathways in bacteria, are comprised of two proteins: a signal-sensing histidine kinase (HK) and an output-generating response regulator (RR). Classically, individual TCSs have been viewed as simple input-output systems, in which signal propagate via phosphorylatio... |
41388847 | Thermal Induced Changes in Cuticle and Cortex to Chemically Treated Hair. | The deterioration of the cuticle and cortex hair due to routine cosmetic practices has been identified as a primary factor contributing to undesirable changes in the esthetic qualities of hair. Chemical and physical treatments can cause significant damage to hair fibers. In this study, the damage induced by heating in ... |
41387371 | Investigation of the Interaction Between HSA and Dioscorea pentaphylla Leaf Extract-Mediated Silver Nanoparticles Using Multi-Spectroscopic and Calorimetric Techniques and Evaluation of Their Anti-Biofilm Activity. | This study aimed to develop a simple, rapid and eco-friendly method for the synthesis of silver nanoparticles (SNPs) employing the aqueous leaf extract of the medicinal plant Dioscorea pentaphylla as a natural and cost-effective reducing and stabilising agent. The synthesised Dp-SNPs were comprehensively characterised ... |
41384796 | Developing antisense oligomer biotics "asobiotics" as precision antibacterials: designs, strategies, and considerations for future success. | Antimicrobial resistance poses a pressing global health challenge in the 21st century. The rapid increase and prevalence of multidrug-resistant bacteria will require novel approaches to develop new antibiotics. Major advances in nucleic acid-based therapeutics, particularly antisense technologies, could be one solution... |
41366685 | Targeting uPARAP with an Antibody-Drug Conjugate Exhibits Efficacy against Mesothelioma and Synergizes with Cisplatin. | Urokinase plasminogen activator receptor-associated protein (uPARAP) is a collagen-internalizing receptor with emerging relevance as a therapeutic target. The involvement of uPARAP in extracellular matrix turnover and stromal remodeling within the tumor microenvironment (TME) makes it an especially promising target in ... |
41365692 | Uncovering the Structural Logic of Grb7: From Domain Mutagenesis to Therapeutic Implications in Cancer Signaling. | Grb7 is a member of the Grb7 protein family, which also includes Grb10 and Grb14. These adaptor proteins function mainly as scaffolds in phosphorylation-dependent signaling pathways. The family is known to interact with receptor tyrosine kinases and other signaling molecules, and their activity is influenced by protein... |
41363051 | Neoadjuvant Under-Dilated TIPS: Expanding Surgeries for Extrahepatic Malignancies in Patients With Cirrhosis and CSPH. | <h4>Background & aims</h4>Portal hypertension is a major challenge in patients with cirrhosis requiring surgery. This study aimed to evaluate the efficacy of under-dilated neoadjuvant transjugular intrahepatic portosystemic shunt (U.N-TIPS) in enabling elective extrahepatic oncologic surgery in patients with cirrhosis ... |
41362733 | SLC25A1-Mediated Cholesterol Accumulation Promotes Endometriosis Progression by Enhancing Endometrial Stromal Cell Proliferation, Invasion, and M2 Macrophage Polarization. | Endometriosis is an estrogen-dependent chronic inflammatory disorder. Cholesterol (CHO) has been reported to be closely associated with estrogen synthesis and inflammatory responses. Nevertheless, the mechanisms underlying the effects of cholesterol on endometriosis progression and immune response remain to be elucidat... |
41362727 | Mechanical Microenvironment in Tumor Immune Evasion: Bidirectional Regulation Between Matrix Stiffness and Immune Cells and Its Therapeutic Implications. | Immune evasion remains a major obstacle to effective cancer immunotherapy. While the regulatory mechanisms of the tumor biochemical microenvironment are relatively well-characterized, the role of its mechanical microenvironment-particularly pathologically elevated matrix stiffness-in immune evasion remains to be fully ... |
41361972 | Therapeutic Perspectives of SIRT6 Regulation: Computational Analysis of Activation and Inhibition by Bioactive Molecules. | Sirtuin 6 (SIRT6) is an enzyme belonging to the class of nicotinamide adenine dinucleotide (NAD+) dependent histone deacetylases. It has been of interest due to its multivariate biological role and association with aging-related diseases and metabolic dysfunctions. SIRT6 activation protects against metabolic diseases a... |
41356200 | Mitochondria-specific targeting of noncanonical <i>EGR1</i> ntmRNA-coordinated mitophagy receptor BNIP3 homodimerization disrupts mitochondrial metabolism and suppresses hepatocellular carcinoma growth <i>in vitro</i> and <i>in vivo</i>. | <b>Background:</b> Hypoxia-driven metabolic reprogramming is a hallmark of hepatocellular carcinoma (HCC) and depends critically on mitochondrial signaling. We sought to identify RNA-based molecular factors that orchestrate the hypoxia-mitochondria crosstalk and regulate metabolic adaptation in HCC cells. <b>Methods:</... |
41356203 | Mannose and phenylboronate ester functionalized mesoporous silica nanoparticles contained in chitosan microneedles for enhancing cellular immunity and antitumor efficacy. | <b>Rationale</b>: Immunotherapy has emerged as a crucial component in cancer treatment, particularly for the long-term reduction of cancer metastasis and recurrence. However, its development is hindered by limited activation of cellular immune response and suboptimal delivery of vaccine to antigen-presenting cells. <b>... |
41356205 | Pharmacologically inherited carbon dots from <i>Salvia miltiorrhiza</i> with potent antioxidant activity and multi-pathway modulation for myocardial ischemia-reperfusion injury therapy. | <b>Rationale:</b> Myocardial ischemia-reperfusion (I/R) injury remains a major clinical challenge that limits the efficacy of reperfusion therapy in acute myocardial infarction, mainly due to excessive production of reactive oxygen species (ROS) and the resulting oxidative stress, inflammation, and cardiomyocyte death.... |
41356198 | Self-boosting targeted anticancer therapy <i>via</i> cancer cell self-reprogramming with GGT-targeting oxidative stress nanoamplifiers. | <b>Rationale:</b> <i>Gamma</i>-glutamyl transferase (GGT) is overexpressed on cancer cell membranes and has been widely used as a promising target for receptor-mediated therapy. However, its heterogeneous expression limits targeting efficacy. Based on the notation that reactive oxygen species (ROS) upregulate GGT and i... |
41356194 | ROS-Responsive Double-Layer Microneedles Enable Sequential Antibacterial and Immunomodulatory Therapy for Infected Wound Healing. | <b>Background:</b> The healing of chronically infected wounds is severely hindered by persistent inflammation, bacterial infection, and oxidative stress, posing great challenges to clinical therapy. To address these challenges, we designed a multifunctional dual-layer microneedles patch (MN@DOX+RES) featuring reactive ... |
41356190 | Programmable molecular microscopy: CRISPR/Cas fluorescent probes revolutionizing spatiotemporal genomic imaging. | Bioimaging technologies visually resolve spatiotemporal dynamics of biomolecules, cells, and tissues, enabling essential insights into gene regulation, disease mechanisms, and drug metabolism. CRISPR/Cas-based fluorescent probes transform CRISPR from "genetic scissors" into "molecular microscopes," providing an indispe... |
41356188 | Fabrication of a conductive, ionic liquid functionalized, oxygen-generating hydrogel loaded with ADSC-derived exosomes to enhance angiogenesis and cardiac repair after acute myocardial infarction. | Acute myocardial infarction (AMI) remains one of the most severe and life-threatening cardiac diseases, accounting for a substantial proportion of mortality worldwide and necessitating the development of novel treatment approaches for effective myocardial repair. Biocompatible, ionically conductive injectable hydrogel ... |
41356183 | Long-acting management of diabetes and associated complications using an injectable thermosensitive hydrogel incorporating IgG-conjugated GLP-1RA. | <b>Rationale</b>: The emergence of glucagon-like peptide-1 receptor agonists (GLP-1RAs) has advanced diabetes management. Nevertheless, frequent administration remains a challenge, even with weekly formulations. Herein, we developed a sustained-release hydrogel-based delivery system for Efsubaglutide Alfa (Suba), an Ig... |
41356182 | Emergence of a barium metal-organic framework for mitigating off-target effects of alpha radionuclide therapy. | <b>Background:</b> <sup>224</sup>Ra, an alpha-emitting radionuclide with a half-life of 3.63 d, holds significant promise in cancer therapy. However, like many other medical alpha-emitters, the development of <sup>224</sup>Ra radiopharmaceuticals has long been impeded by dosimetry limitation caused by the off-target to... |
41355972 | Design of prodrugs with reactive oxygen species as activators and their application in tumor therapy. | Major challenges lie in the precise management (encompassing diagnosis and treatment) of malignant neoplasms. Traditional chemotherapy faces restrictions in clinical use because of its ineffective targeting and significant toxicity, along with side effects. Notably, the ROS levels are observably elevated in cancer cell... |
41355968 | Precision targeting of FDX1-mediated cuproptosis by a ROS-responsive hydrogel for myocardial ischemia-reperfusion injury treatment. | <b>Rationale:</b> Myocardial ischemia-reperfusion injury (MIRI) poses a critical clinical challenge due to intertwined oxidative stress and cuproptosis-driven cell death. Current therapies inadequately address dual-pathology mechanisms (ROS overproduction and copper dysregulation), while conventional drug delivery lack... |
41355964 | Nanomedicine for targeting cancer-associated fibroblasts in cancer therapy. | Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment, where they facilitate tumor progression, angiogenesis, immune evasion, and treatment resistance, highlighting the urgent need for CAF-targeted strategies for high-performance tumor therapy. Recent nanomedicine approaches have shown ... |
41355962 | Systemic targeting of aberrant neovascular tufts using trehalose-dendrimer nanocarriers for the treatment of proliferative retinopathies. | <b>Rationale:</b> Proliferative retinopathies are the leading causes of blindness worldwide. Current treatment paradigms rely heavily on intravitreal injections of anti-vascular endothelial growth factor A (anti-VEGFA) agents, which, despite their efficacy, are associated with ocular complications and patient discomfor... |
41355950 | Advances in the engineering of living probiotics for cancer immunotherapy. | The role of bacteria in tumor development has been increasingly recognized through advances in sequencing technologies, revealing their influence on the tumor microenvironment and immune system. Live bacterial therapy, known for its unique ability to target tumors, colonize cancerous tissues, and activate immune respon... |
41355949 | Engineering and evaluation of precision-glycosylated clickable albumin nanoplatform for targeting the tumor microenvironment. | <b>Rationale:</b> Glycosylation of drug delivery vehicles enables selective tumor microenvironment (TME) targeting but is limited by the lack of precise glycan control and unbiased evaluation of in situ targeting. We developed a clickable albumin nanoplatform engineered by distinct glycosylation for selective <i>in viv... |
41355599 | Click Reactions: A Paradigm Shift in Food Chemical Residue Testing. | Chemical residues in food pose a global health challenge, which necessitates sensitive and reliable detection methods. Current techniques (e.g., chromatography and immunoassays) remain limited by operational complexity, insufficient sensitivity, and poor adaptability for on-site use. Click chemistry has emerged as a no... |
41355585 | The Safety and Quality of Staple Root and Tuber Crops: A Review on Hazards, Detection Methods, and Mitigation Strategies. | Staple root and tuber crops (SRTCs), including potatoes, cassava, sweet potatoes, yams, and taros, play vital roles in global nutrition. However, they present significant safety hazards, which poses threats to human health, have garnered widespread public concern, and consequently constrain the further development and ... |
41355549 | Functionality Enhancement of Pullulan-Based Composites for Food Packaging Applications. | Contemporary research in food packaging is focused on developing sustainable alternatives to petroleum-based materials. Pullulan, a microbial biopolymer traditionally employed as a food additive, is harnessing interest for food packaging applications due to its exceptional film-forming ability, biodegradability, and no... |
41355537 | Deciphering Pigmented Rice Varieties as Sustainable and Unexplored Valuable Sources of Bioactive Components With Health-Related Properties and Technological Applications-A Systematic Review. | The interest in pigmented grains has grown substantially in recent years. Pigmented rice is crucial for diversifying agricultural production and promoting healthier, more balanced diets. This systematic review updates and discusses literature published between 2019 and 2024 on the bioactive compounds in pigmented rice,... |
41347327 | Multidimensional Interrogation of the Toxicity-Efficacy Balance in Chinese Medicinal Alkaloids via MOFs, Network Pharmacology, and Chromatography. | Metal-organic frameworks (MOFs) offer a revolutionary platform for addressing the inherent toxicity-efficacy paradox of bioactive alkaloids in traditional Chinese medicine (TCM). This review summarizes recent advances in MOF-based strategies for detoxification and potentiation of alkaloid drugs by integrating TCM holis... |
41347276 | Recent Advances in Lemongrass Essential Oil: Food Safety, Preservation, and Bioactivity in Food Systems. | Lemongrass essential oil (LGEO) has gained recognition as a natural preservative in food systems due to its distinctive phytochemical composition and multifunctional bioactivities. Dominated by citral and complemented by terpenes and phenolic compounds, LGEO demonstrates potent antibacterial, antifungal, antiviral, ant... |
41346712 | AI and organoid platforms for brain-targeted theranostics. | Developing therapies for complex brain diseases faces significant challenges due to biological complexity and the stringent blood-brain barrier. While nanomedicine holds promise, traditional R&D paradigms suffer from inefficiency. This review introduces an intelligent theranostic paradigm that integrates high-fidelity ... |
41346710 | Tumor mRNA-lipid nanoparticles via chimeric nanobody-lipid co-assembly. | <b>Background:</b> Targeted mRNA-lipid nanoparticles (LNP) show great potential for cancer immunotherapy by delivering neoantigen-encoding messages to tumor cells, prompting immune responses against tumors. However, the challenges of inefficient production of targeting ligand-grafted LNPs and the immunogenic effects of... |
41346708 | Endocrine nanozymology: Nanozyme applications in diabetes, obesity, and hormonal disorders. | Nanozymes, engineered nanomaterials with enzyme-like catalytic activity, are emerging as versatile tools in biomedicine due to their catalytic tunability and higher chemical, thermal, and structural stability compared to natural enzymes. While widely studied in oncology and inflammation, their potential in endocrine di... |
41346705 | Piezo1 induces Wnt7b<sup>+</sup> astrocytes transformation to modulate glial scar stiffness and neuro-regeneration after stroke. | <b>Background:</b> Reactive astrocytes form a chemical and mechanical glial scar that inhibits neuro-regeneration after stroke. Astrocyte heterogeneity is accompanied by changes in morphology and mechanical properties altering during scar formation after injury. This work aimed to elucidate the relationship between gli... |
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