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41552578 | Ionic Liquids in Pharmaceuticals: A Scoping Review of Formulation Strategies. | Ionic liquids (ILs) have rapidly emerged as multifunctional formulation tools capable of addressing long-standing challenges in drug delivery. This scoping review systematically assessed their pharmaceutical applications through a structured search of Scopus, PubMed, and Web of Science, yielding 1866 records, of which ... |
41551565 | Practical aspects of teaching a graduate-level small-mol-ecule chemical crystallography course. | We present the practical curriculum of the graduate Chemical Crystallography course in the Department of Chemistry of the University of Wisconsin-Madison, outlining our favorite resources, texts, and software. The course relies on collaborative in-class student assignments that build up a knowledge base of fundamental ... |
41551549 | Synthesis and crystal structure of 5,17-di-amino-11-<i>tert</i>-butyl-25,26,27,28-tetra-prop-oxy-23-[(tri-phenyl-meth-yl)amino]-calix[4]arene di-chloro-methane monosolvate. | The title compound crystallizes as a di-chloro-methane monosolvate, C<sub>63</sub>H<sub>73</sub>N<sub>3</sub>O<sub>4</sub>·CH<sub>2</sub>Cl<sub>2</sub>. The main mol-ecule represents a calix[4]arene and possesses a pinched cone shape, with the two distal <i>para</i>-amino groups at the wide rim of the macrocycle being ... |
41551530 | Herbal medicine beyond probiotics: Yiyi Fuzi Baijiang powder and the holistic regulation of gut microbiota in ulcerative colitis. | We read with great interest the study by Zhang <i>et al</i> on Yiyi Fuzi Baijiang powder (YFB), which exemplifies the power of modern methods to validate traditional Chinese medicine (TCM). The key insight is that YFB doesn't merely alter "good" or "bad" bacteria but restores the gut microbiota's holistic equilibrium. ... |
41551527 | Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis. | Acute pancreatitis (AP) is sudden inflammation of the pancreas, which can lead to multiple organ dysfunction in severe cases. Hypertriglyceridemia (HTG) is the third most common cause. In recent years, HTG-induced AP (HTG-AP) has garnered increasing attention. Compared to AP caused by other causes, HTG-AP often has a m... |
41549663 | Liposomal amphotericin B and renal safety: review of the evidence and clinical considerations. | Invasive fungal infections continue to represent an important cause of morbidity and mortality in severely ill and immunocompromised patients. Liposomal amphotericin B (LAmB) has a significantly improved toxicity profile versus conventional amphotericin B deoxycholate and is recommended for a wide range of medically im... |
41549528 | Comparative Analysis of Extracellular Vesicle Isolation From Equine Serum and Plasma Using Two Isolation Methods With Structural and Proteomic Validation. | Extracellular vesicles (EVs) are promising biomarkers and mediators of intercellular communication, but their isolation from equine biofluids remains challenging. This study compared two isolation workflows-size-exclusion chromatography (SEC) and differential ultracentrifugation followed by SEC (UC + SEC)-to evaluate t... |
41549213 | Bioresorbable Electrically-Active Neuromodulation Materials & Devices. | Bioresorbable electrically-active neuromodulation devices (BEANDs) integrate degradable materials with the neuromodulation function of electrical stimulation, allowing the implants to gradually resorb after completing their therapeutic tasks and thereby eliminating the need for secondary removal surgery. This technolog... |
41549224 | Multifunctional NiCo<sub>2</sub>O<sub>4</sub>-NC Heterostructure Nanocage Modified Separator for Mitigating the Shuttle Effect and Kinetic Challenges in Lithium-Sulfur Batteries. | Lithium-sulfur batteries have garnered significant attention from the scientific community due to their intrinsic advantages, including low cost, abundant resources, and high specific energy. However, the shuttle effect of soluble polysulfides and the sluggish redox kinetics of sulfur species have greatly hindered thei... |
41543496 | Core Concepts for Early Childhood Microbiology Education. | This article explores how microbiology can be meaningfully integrated into science education for preschoolers, children under 6 years old. Current research shows that the early years represent a critical period for scientific learning. Microbiology offers a unique opportunity to engage children in curiosity, and reflec... |
41543350 | Anti-Inflammatory Properties of Ripe and Unripe Papaya Pectin in a Neonatal Human Stem Cell-Derived Ileum Model. | Pectin, a dietary fiber found in fruits and vegetables, has recognized anti-inflammatory properties. While papaya is rich in pectin, the impact of different ripening stages on its anti-inflammatory effects within the human neonatal gastrointestinal tract remains unexplored. Ripe and unripe papaya contain structurally d... |
41543331 | Rice Starch-Purple Red Rice Bran Anthocyanins Complex Improves Glucose-Lipid Homeostasis and Restores Gut Microbiota in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Mice. | Purple red rice bran, a nutrient-rich byproduct of rice processing, contains abundant anthocyanins that distinguish it from ordinary bran and may offer metabolic benefits, while previous in vitro work has revealed that anthocyanins can form V-shaped inclusion complexes with rice starch (S-A), thereby enhancing resistan... |
41543289 | Structure and solution biospeciation on tricarbonylrhenium(I) complexes of mercaptopyrimidines with multifaceted biological activity. | In this study, we report the synthesis and detailed characterization of four novel bidentate (N, N) ligands incorporating a 2-(methylthio)pyrimidine moiety and their fac-tricarbonylrhenium(I) complexes (ReB1-ReB4 and ReB1Aq) with the general formula fac-[Re(CO)3(N,N)X]n+, with X = Cl- or H2O and n = 0 or 1. Designed to... |
41542713 | Trends on Strategies for Mitigation of Antibiotic Residues in Milk and Dairy Products Based on Scientometric Analysis and Systematic Review. | The presence of antibiotic residues (ARs) in milk poses a significant challenge to public health and the dairy industry. This study presents the research trends on strategies to mitigate ARs in milk and dairy products, combining scientometric and systematic review approaches. Following the PRISMA guidelines, data from ... |
41540766 | Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double-Blind, and Placebo-Controlled Trial. | <h4>Background/objectives</h4>Medicinal mushrooms have been gaining increasing attention as functional foods; however, scientific evidence from human studies remains limited.<h4>Methods</h4>In this study, 50 participants were randomly assigned to receive either Restake or a placebo. Psychological and physiological para... |
41540716 | Recent Advances in Plasmon-Assisted Optical Sensing of Inflammatory Biomarkers. | The precise monitoring of specific inflammatory biomarkers is crucial for the accurate diagnosis and management of inflammation and infections, as well as for determining the most effective treatment. Recently, there has been a growing interest in innovative methods employing optical biosensors based on plasmonic nanop... |
41539985 | Microplastics and Nanoplastics as Carriers for Viral Transmission: Effects on Viral Properties, Infection, Immune Response, and Public Health. | The extensive use of plastics since the industrial revolution has raised significant environmental and health concerns. Despite their advantages in terms of durability, affordability, and ease of production, the accumulation of plastics has resulted in considerable pollution. The SARS-CoV-2 pandemic further exacerbated... |
41539715 | [Bioactive substances delivery for bone repair via nanocomposites: advantages, mechanisms, and emerging trends]. | <h4>Objective</h4>The advantages, mechanisms, and advances in nanocomposites for delivering bioactive substances in bone tissue engineering were systematically reviewed.<h4>Methods</h4>This review provides a comprehensive analysis by conducting an in-depth retrieval of relevant literature and integrating it with relate... |
41539700 | [State-of-the-art in peripheral nerve injury diagnosis and therapy]. | The undulating characteristics of nerve fibers and the endoneurium are important factors in resisting traction force. The diagnostic accuracies of magnetic resonance neurography and ultrasonography for nerve injuries are 85.4% and 70.6%, respectively. Epineurial repair is the most commonly used nerve repair technique. ... |
41539281 | Extended Tetrathiafulvalenes: Intramolecular Interactions Within 2,2'-Biphenyl-Bridged Fluorene-Dithiafulvenes. | Tetrathiafulvalene (TTF) is a well-known redox-active molecule that undergoes two reversible one-electron oxidations to afford stable cationic species. Its redox and optical properties, as well as molecular geometry and self-association behavior, can be systematically tuned through incorporation of a π-conjugated frame... |
41538875 | Photothermal microtip with "nanotrap" on a fiber-optic end-face grating for specific sensing of inert gas Xe. | This study proposes a fiber-optic xenon (Xe) sensor with photothermally tunable gas concentration sensitivity (PTGCS). A polymer microtip doped with Xe-selective material MOF-1 and photothermal material MOF-2 on the single-mode fiber (SMF) end face acts as a Fabry-Pérot (FP) sensor for Xe gas detection. MOF-2 can contr... |
41538840 | Laser direct writing of metal-organic framework-5 microstructures. | We report a femtosecond laser direct writing (LDW) method for localized in-situ fabrication of highly crystalline metal-organic framework-5 (MOF-5) microstructures directly from a precursor solution. Confined photothermal reactions induced by tightly focused pulses enable site-selective crystallization without pre- or ... |
41537757 | Preventing Age-Related Nuclear Cataract Development - Is Cholesterol the Key? | The cholesterol content in the membranes of the fiber cells of the human eye lens is significantly higher than in any other cell of the body. This review examines the existing literature on the origin and function of this unique feature as one of multiple factors that may help protect against age-related cataract forma... |
41533726 | Pyridine and N-Pyridinium Functionalized Macrocyclic Squaramide Anion Receptors with High Affinity for Aqueous Sulfate. | Macrocyclic squaramide-containing receptors have previously been shown to bind sulfate with high selectivity and affinity in aqueous-organic mixtures. To increase binding affinity of this class of hydrogen-bonding receptors in pure water, macrocycles in which pyridinium groups have been inserted to provide additional c... |
41533592 | Optogenetic BlueGENEs engineered into a human safe harbor locus. | Crafting synthetic in vitro tissues with mammalian cells faces a shortage of methods to define spatial features. Optogenetic tissue engineering can provide the desired spatial and temporal control but requires stable genomic engineering to support long-term cultivation and high response resolution. Here, we developed B... |
41533579 | Dps binds and protects DNA in starved Escherichia coli with minimal effect on chromosome accessibility, dynamics, and organization. | Dps is the most abundant nucleoid-associated protein in starved Escherichia coli with ∼180 000 copies per cell. Dps binds DNA and oxidizes iron, facilitating survival in harsh environments. Dps-DNA complexes can form crystalline structures, leading to the proposed model that Dps reorganizes the starved E. coli nucleoid... |
41533578 | Structure and function of the nairovirus cap-snatching endonuclease. | Nairoviruses include several human pathogens such as Crimean-Congo hemorrhagic fever virus (CCHFV) and Kasokero virus (KASV). The cap-snatching endonuclease (EN) domain of the viral polymerase is essential for transcription and represents a promising antiviral target. However, the structural and functional mechanisms o... |
41533572 | Safeguarding genome integrity: Polo-like kinase Cdc5 and phosphatase Cdc14 orchestrate Topoisomerase II-mediated catenane resolution in mitosis. | Resolution of sister chromatid intertwines in mitosis is vital for safeguarding genome integrity. While cohesin, condensin, the polo-like kinase Cdc5, and the phosphatase Cdc14 have all been implicated in this process, the underlying molecular mechanisms remain elusive. Our study unveils a coordination between spindle ... |
41533569 | The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription-replication conflicts. | R-loops play essential physiological roles but also pose a significant threat to genome stability, particularly during replication, by exacerbating transcription-replication conflicts (TRCs). In this study, we have uncovered a critical role of the SMC5/6 complex in resolving TRCs to preserve fork integrity. We identifi... |
41533565 | Metal ions govern coronavirus endoribonuclease activity. | Coronavirus nonstructural protein 15 (nsp15) is an endoribonuclease that restricts viral double-stranded RNA (dsRNA) accumulation in the cytosol to evade host immunity. Given the co-localization of nsp15 and replicating viral RNA, the mechanism controlling nsp15 activity is essential, yet poorly understood. Although me... |
41533504 | Differential Self-Assembly Behaviors and Proteolytic Stability of Bicyclic Peptides Compared to Monocyclic Peptides. | Self-assembling cyclic peptides exhibit several advantages over their linear counterparts; however, the structural simplicity of monocyclic peptides (MCPs) limits their further development into assemblies with more elaborate and complex functions. Here, we demonstrate that bicyclic peptides (BCPs) offer significant pot... |
41533494 | Synthesis, Characterization, Crystal Structure and Anti-TB and Anticancer Applications of Redox Active Phenanthroline Derivatized With Methyl-, Ethyl-, and Benzyl Carbazates. | Developing new molecules for treating bacterial infections and cancer disease is an important area of exploration as both types of cells often develop resistance to known drug candidates. Synthesis, structural characterization, and bioactivity of heterocyclic compounds 6-[2-(benzyloxycarbonyl)diazen-1-yl]-1-10-phenanth... |
41533480 | Electrocatalysis by Coinage Metal Nanoclusters of Atomic Precision: Tailoring Catalytic Reactivity and Stability by Ligands and Composition. | Atomically precise coinage metal nanoclusters (NCs) have emerged as a powerful platform for uncovering structure-property relationships and for various applications. aOwing to their well-defined atomic structures, discrete electronic states, and tunable surface environments, these NCs enable systematic studies of activ... |
41537246 | GAMMA: gap-aware motif mining under incomplete labeling with applications to MHC motifs. | <h4>Motivation</h4>Sequence motif identification is crucial for understanding molecular recognition, particularly in immune responses involving peptide binding to major histocompatibility complex (MHC) Class I molecules for antigen presentation to T cells. Traditionally, MHC Class I binding motifs are assumed to be con... |
41533289 | Self-Grown Carbon Nanotube Encapsulated Co Nanoparticle Compound Fe-Nx/Mesoporous Carbon as Bi-Functional Electrocatalyst to Drive Efficient Electrochemical Overall Water Splitting. | Electrochemical overall water splitting is one of the main choices to realize hydrogen energy. In this study, a simple strategy of self-growth of carbon nanotubes with the tip end of Co nanoparticles compound Fe-Nx/mesoporous carbon as bi-functional electrocatalyst is proposed. At high temperature, cobalt nanoparticles... |
41532888 | Bioactivity-Guided Isolation of β-Sitosterol From Terminalia glabrescens as a Potent Anti-Zika Virus Agent. | Zika virus (ZIKV) infection remains a global health concern due to its neurological complications and the lack of specific drugs or vaccines. This study investigated the anti-ZIKV potential of an ethanolic extract from Terminalia glabrescens leaves. Dereplication of the extract by UPLC-ESI-MS/MS identified 27 phenolic ... |
41532848 | Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study. | The essential oil of Pilocarpus microphyllus (jaborandi) (EOJ), a species traditionally recognized for its alkaloid-based pharmacological properties, remains poorly investigated despite its richness in bioactive terpenes. In this study, the chemical profile of EOJ obtained from fresh and dried leaves was determined by ... |
41531310 | Ferritin-Based Pravastatin Assembly Augments Mucus Penetration and Ameliorates Acute Lung Injury Via Rho/ROCK Signaling Pathway. | Acute lung injury (ALI) is a common respiratory disease accompanied by alveolar capillary membrane dysfunction, inflammation and alveolar fluid deposition. Currently, the primary treatment for ALI involves intravenous or oral administration of glucocorticoid drugs. However, this approach suffers from low effective drug... |
41531305 | Genotype Differences and Hydroxyurea Utilization Among Adults With Moderate to Severe Sickle Cell Disease. | <h4>Backgrounds</h4>Hydroxyurea (HU) remains underutilized in adults with sickle cell disease (SCD) despite proven benefits. Current HU guidelines primarily target sickle cell anemia (SCA), overlooking other genotypes.<h4>Objectives</h4>This study examined HU utilization patterns across genotypes among adults considere... |
41530093 | [Controlled synthesis of high-capacity bisphenol A molecularly imprinted polymer and its application to the detection of environmental water samples]. | Bisphenol A （BPA） is an endocrine-disrupting chemical that mimics estrogen， thereby interfering with human hormonal balance and leading to reproductive abnormalities， developmental disorders， and increased risks of obesity， diabetes， and cancer. Commonly found in plastic products and food packaging materials， BPA can r... |
41530091 | [Research progress in the application of molecular imprinting technology in catalysis]. | The synergistic enhancement of catalytic activity and selectivity constitutes a critical challenge in modern heterogeneous catalysis， which directly influences target product yield， reaction energy efficiency， and process economics. Molecular imprinting technology （MIT） has demonstrated exceptional potential in overcom... |
41530092 | [Fabrication of high-degradation-efficiency molecularly imprinted photocatalysts and its selective degradation performance]. | Molecularly imprinted photocatalysts （MIPCs）， which integrate specific molecular recognition with photocatalytic degradation capabilities， hold great promise for the selective and efficient removal of trace pollutants from complex environmental matrices. However， conventional surface-imprinting layers coated on photoca... |
41530090 | [Progress in electric field assisted molecular imprinting technology]. | Molecular imprinting technology （MIT） simulates the specific recognition mechanism between antibodies and antigens， and can construct separation media with specific recognition performance， demonstrating unique advantages in the fields of separation， purification， and trace detection in complex sample matrices. Molecul... |
41530089 | [Molecular imprinting strategies and advances targeting biomembranes]. | Biomembranes are selective barriers and communication interfaces between intracellular and extracellular environments. They are crucial for signal transduction， energy transfer， and material exchange. Composed of lipids， proteins， glycans， and other components， biomembranes are central platforms for cell recognition an... |
41529119 | DeepRMSF: a deep learning-based automated approach for predicting atomic-level flexibility in RNA structure. | Understanding RNA conformational dynamics is essential to understand its roles in complex biological processes. While computational methods have revolutionized the prediction of static 3D RNA structures, predicting local flexibility directly from structure remains a significant challenge. We developed DeepRMSF, a deep ... |
41527704 | Improving in vitro Gastrointestinal Stability of Phlorotannins From Food Grade Fucus vesiculosus Extracts Using Cyclodextrins. | Phlorotannins have gained significant attention for their potential bioactive and functional properties. However, these compounds are highly sensitive to gastrointestinal digestion, which limits their bioavailability and consequently the in vivo efficacy. To address this limitation, this study explored the use of vario... |
41527489 | L-Quebrachitol Enhances Sedative Effect of Diazepam Through GABAergic Pathway: Animal and Computational Studies. | <h4>Introduction</h4>Insomnia and other sleep disorders are becoming increasingly prevalent worldwide, while current sedative medications such as benzodiazepines, though effective, are often limited by side effects and dependency risks. Therefore, identifying safe natural compounds with sedative potential is of growing... |
41526240 | Spider silk-based structural proteins as tough, biodegradable, and sustainable polymers. | Spider silk has garnered significant attention across diverse research fields because of its remarkable physical and biological properties, which have driven extensive efforts to develop materials and fabrication processes that replicate its unique characteristics. This review focuses on the structure of silk fibers an... |
41526256 | Surgical Outcomes of Stanford Type A Aortic Dissection in Jehovah's Witness Patients. | <h4>Purpose</h4>Surgery for Jehovah's Witness patients with Stanford type A aortic dissection (TAAD) carries a high surgical risk, and few reports have examined outcomes in this patient population. This study evaluated perioperative outcomes of surgery for TAAD in Jehovah's Witness patients.<h4>Methods</h4>Eight Jehova... |
41526238 | Bioorganic studies on the nyctinastic leaf-movement of plants. | Nyctinasty, a circadian-regulated leaf movement observed in legumes, has long intrigued scientists. This study identified genus-specific endogenous chemical factors, leaf-closing factors (LCFs) and leaf-opening factors (LOFs), that control this rhythmic behavior. In Samanea saman, a model for nyctinasty, the LCF 12-hyd... |
41522356 | Gut Metabolite Indoleacrylic Acid Suppresses Osteoclast Formation by AHR mediated NF-κB Signaling Pathway. | Bone homeostasis relies on the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. Disruption of this balance leads to osteoporosis, a highly prevalent bone disease with substantial health impacts in middle-aged and older adults. There is accumulating evidence linking the development of o... |
41522338 | Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders. | Monocyte-macrophage plays a central role in innate immunity, tissue homeostasis maintenance, and disease progression. These phagocytes, which originate from blood monocytes or embryonic sources, are imperative for inflammatory responses, tissue repair, and bone remodeling. In orthopedic diseases, including osteoarthrit... |
41521814 | C-C motif receptor 2 is a core profibrotic factor in uremic cardiomyopathy. | Uremic cardiomyopathy (UC) represents a leading cause of mortality in patients with chronic kidney disease (CKD), characterized by left ventricular hypertrophy (LVH) and fibrosis. The underlying mechanisms of UC pathogenesis remain incompletely understood. This study developed two methods to simulate human UC - modifie... |
41521663 | Structural insights into σ28-dependent transcription initiation and its regulation by anti-sigma factor in Pseudomonas aeruginosa. | Late flagellar genes in Pseudomonas aeruginosa are transcribed by the group 3 sigma factor, FliA (σ28). σ28 drives the expression of flagellin, which assembles into the flagellar filament in this monoflagellated bacterium. This function is suppressed by the anti-sigma factor FlgM. Here, we present the 1.95Å resolution ... |
41521670 | Bringing the ends together: cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis. | Non-homologous end joining (NHEJ) is the sole pathway for repairing double-strand breaks in Mycobacterium tuberculosis during dormancy, relying on mycobacterial Ku (mKu) and ligase D, with mKu as the rate-limiting factor. Despite its essential role, the lack of structural information on prokaryotic Ku has hindered unde... |
41521659 | Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo. | Short interfering RNAs (siRNAs) represent a novel class of therapeutic modalities, where, in the context of complex chemical modification patterns, a single administration can support sustained gene silencing. Various siRNA architectures demonstrate robust activity; however, a guide strand length of 19-21 nucleotides i... |
41521463 | Cocaine-Induced Changes in the BRD4 Interactome Identifies Casein Kinase 1 Epsilon as a Therapeutic Target. | Recent research has revealed that BRD4, a bromodomain and extra terminal domain (BET) epigenetic "reader" protein, plays an essential role in regulating behavioral and molecular responses to cocaine. To date, the roles of BRD4 and other BET proteins in substance use disorder (SUD) models have been mainly studied using ... |
41521398 | Liposome-Based Potential Vaccines Platforms that Are Noncytotoxic. | Synthetic vaccines represent a promising avenue in cancer immunotherapy by promoting targeted immune responses. Liposomal technologies have further advanced synthetic vaccinology by enabling the efficient delivery of tumor-associated carbohydrate antigens. Despite this progress, the toxicity and reproducibility of such... |
41521160 | Theranostic Nanoparticles in Prostate Cancer: Disrupting Hypoxia-Induced Glycolysis by Targeting Hypoxia-Inducible Factor-1 Alpha and Downstream Metabolites. | <h4>Background</h4>Prostate cancer (PCa) is a major cause of cancer-associated death in men. A crucial factor in its development and treatment resistance is tumor hypoxia, which drives metabolic reprogramming (especially reconfiguration towards glycolysis), mediated to a great extent by hypoxia-inducible factor-"HIF-1 ... |
41520295 | RP3Net: a deep learning model for predicting recombinant protein production in Escherichia coli. | <h4>Motivation</h4>Recombinant protein expression can be a limiting step in the production of protein reagents for drug discovery and other biotechnology applications. We introduce RP3Net (Recombinant Protein Production Prediction Network), an AI model of small-scale heterologous soluble protein expression in Escherich... |
41520230 | ProTCR: a protein language model-driven framework for decoding TCR-antigen recognition toward precision immunotherapies. | The ability of T-cell receptors (TCRs) to recognize neoantigens is fundamental to the initiation and maintenance of adaptive immune responses. In TCR-based immunotherapies, elucidating the recognition patterns of TCRs for peptides and accurately identifying therapeutically relevant TCR-peptide pairs remain critical cha... |
41518355 | New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti-Tumor Activity Against Ewing Sarcoma. | In the past few years, several novel anticancer agents targeting protein kinases have been discovered expanding the available therapeutic arsenal. However, few new therapeutic approaches have been developed for the treatment of childhood cancer. To this end, we have been making efforts to contribute to this important f... |
41517950 | Selection and Characterization of SARS-CoV-2 Spike Binding Clickmers. | Expanding the chemical repertoire of canonical nucleotides is key to unlocking the full functional potential of aptamers for diagnostic use. Herein, click-systematic evolution of ligands by exponential enrichment (SELEX) is employed to generate chemically modified DNA aptamers, termed clickmers, that target the SARS-Co... |
41517659 | Ultrasound in medicine from 2014 to 2024: A bibliometric review. | <h4>Background</h4>The unique physical properties of ultrasound technology have led to its increasing recognition in recent years, rendering it an indispensable component in the diagnosis and treatment of various medical conditions. The aim of this study is to investigate the current research status, focal areas, and f... |
41516918 | The Optimal Amount of PAMAM G3 Dendrimer in Polyurethane Matrices Makes Them a Promising Tool for Controlled Drug Release. | Systemic anticancer therapy causes a number of side effects; therefore, local drug release devices may play an important role in this area. In this study, we developed polyurethane-dendrimer foams containing different amounts of third-generation poly (amidoamine) dendrimers (PAMAM G3) to evaluate their ability to encap... |
41516698 | Recent Advances in Nucleic Acid-Based Electrochemical Sensors for the Detection of Food Allergens. | Food allergies represent a growing public health concern, requiring analytical methods capable of detecting trace levels of allergenic ingredients in increasingly complex and processed food matrices. In recent years, nucleic acid-based electrochemical sensors have emerged as a powerful alternative to protein-targeting ... |
41516341 | Recent Advances in Photoelectrochemical Nitrate Reduction to Ammonia. | Ammonia, as an essential chemical, plays an indispensable role in both industry and agriculture. However, the traditional Haber-Bosch technique for ammonia synthesis suffers from high energy consumption and significant CO<sub>2</sub> emissions. Therefore, developing an energy-efficient and eco-friendly method for ammon... |
41516337 | Multicomplex Pharmacophore Modeling of Estrogen Receptors Suggests the Probable Repurposing of Procaterol as an Antiproliferative Agent Against Breast Cancer Cells. | Breast cancer (BC) is a malignant tumor that develops in the mammary gland due to uncontrolled cell proliferation. Estrogen receptor (ER) signaling, mediated by 17β-estradiol (E2), plays a crucial role in regulating cell proliferation, differentiation, and survival. Specifically, the binding of E2 to the estrogen recep... |
41515611 | Predictive Factors of Early and One-Year Mortality in Patients with Acute Pancreatitis. | <b>Background/Objectives:</b> Acute Pancreatitis (AP) is an unpredictable inflammatory disease associated with high morbidity and significant mortality, particularly in severe forms. Early death is primarily linked to Systemic Inflammatory Response Syndrome (SIRS) and Multi-Organ Failure (MOF). The objective of this st... |
41515468 | {Zn<sup>II</sup><sub>2</sub>} and {Zn<sup>II</sup>Au<sup>I</sup>} Metal Complexes with Schiff Base Ligands as Potential Antitumor Agents Against Human Glioblastoma Multiforme Cells. | The challenges of glioblastoma multiforme treatment are related to limitations in tumor removal surgery, its high heterogeneity and aggressiveness, development of resistance to standard therapy, the blood-brain barrier, and the side and toxic effects of the conventional antitumor agents used in clinical practice. Altho... |
41515461 | Unexpected Orange Photoluminescence from Tetrahedral Manganese(II) Halide Complexes with Bidentate Phosphanimines. | Manganese(II) halide complexes with the general formula [MnX<sub>2</sub>{(PhN=PPh<sub>2</sub>)CH<sub>2</sub>}], where X is bromine or iodine and (PhN=PPh<sub>2</sub>)CH<sub>2</sub> is the bis-phosphanimine ligand 1,1'-methylenebis-(<i>N</i>,1,1-triphenylphosphanimine), were prepared and isolated. The structure of the t... |
41515448 | The Remarkable Properties of Oil-in-Water Zein Protein Microcapsules. | Zein (ZP) is the major storage protein of corn (maize). It is safe, biodegradable, edible, and characterized by unique self-assembly properties. These properties were exploited to prepare ZP microcapsules filled with soybean oil (SO) by ultrasound-assisted emulsification of oil-in-water (o/w) dispersions under optimal ... |
41512285 | PLXFPred: interpretable cross-attention networks with hierarchical fusion of multi-modal features for predicting protein-ligand interactions and affinities. | <h4>Summary</h4>Accurately predicting protein-ligand interactions and binding affinities is essential for advancing structural biology. Despite recent advancements in deep learning, achieving rapid and precise predictions remains a challenging task. Our approach, Protein-Ligand Cross-Modal Fusion Predictor (PLXFPred), ... |
41510779 | Peptides Derived From Reactive Center Loops Inhibit Digestive Trypsin-Like Enzymes in Lepidopteran Pests. | Soybean yield is often reduced by pest attacks. Among these, Anticarsia gemmatalis Hübner (Lepidoptera: Noctuidae) stands out as one of the most important defoliating pests of soybean. Therefore, the development of new bioinsecticides targeting Lepidopteran pests is an urgent need. Protease inhibitors (PIs) have emerge... |
41510172 | Nanotechnology-donated ischemic stroke therapeutics: evolving strategies from the basic to the cutting-edge. | Ischemic stroke (IS) is accompanied by high disability and mortality. Thrombolysis and neuroprotection are the predominant therapeutic strategies for IS. However, thrombolytic drugs commonly suffer from hemorrhagic risks and unsatisfactory thrombus-targeting delivery. Additionally, the blood-brain barrier (BBB) present... |
41510170 | Kidney-targeted nanoplatforms: Strategies and applications. | Renal diseases remain a major global health burden, with an estimated 850 million individuals affected by chronic kidney disease, acute kidney injury, glomerulonephritis, and diabetic nephropathy. These multifactorial diseases collectively account for substantial morbidity and mortality burdens. This grim trajectory de... |
41510167 | Lead radionuclides for theranostic applications in nuclear medicine: from atom to bedside. | Lead-212 has emerged as a promising radionuclide for targeted alpha therapy (TAT), positioning itself at the forefront of next-generation cancer treatments. What sets lead-212 apart is its unique decay profile: while it is a beta emitter, it mainly serves as an <i>in vivo</i> generator of the potent alpha-emitting daug... |
41510171 | Ligand-directed oral lipidic nanoplatform enables sustained ferroptosis and immune reprogramming via multivalent transporter-mediated metronomic delivery. | <b>Rationale:</b> Ferroptosis-induced tumor cell death and immune activation represent promising strategies for overcoming therapeutic resistance in triple-negative breast cancer (TNBC). However, clinical application remains limited by poor oral absorption, transient immune activation, and systemic toxicity. <b>Methods... |
41510161 | Piezoelectric Heterojunction-driven Biomedical Revolution: From Construction Principles to Diagnostic and Therapeutic Applications. | Piezoelectric heterojunctions are emerging as a transformative class of smart biomaterials, revolutionizing biomedical applications through their unique mechano-electrical coupling effects. A central challenge hindering their full potential lies in the systematic understanding and utilization of their complex interfaci... |
41510163 | Demystifying anti-inflammatory therapeutic strategies against pancreatitis and concomitant diseases: a 2025 perspective. | Pancreatitis is a complex, progressive inflammatory disorder that often transitions from acute to chronic stages, leading to significant comorbidities such as diabetes, cardiovascular diseases, and bone disorders. These complications complicate treatment strategies, highlighting the need for more targeted approaches. H... |
41510156 | Curcumin coacervates for supramolecular-interaction-responsive cytosolic siRNA delivery to enhance pyroptosis. | <b>Rationale:</b> Synthetic molecules, meticulously designed according to the "sticker-and-spacer model", tend to form coacervates via liquid-liquid phase separation (LLPS), thereby acquiring properties beyond their discrete and soluble states. However, natural compounds, such as those from traditional Chinese medicine... |
41510165 | Targeting CAMK1D-engineered nanoactivator suppresses cancer stem cell maintenance and immune evasion in enzalutamide-resistant prostate cancer. | <b>Rationale:</b> Hormonal therapy is fundamental to prostate cancer (PCa) management; however, its long-term efficacy is compromised by enzalutamide resistance (ENZR), which is fuelled by prostate cancer stem-like cells (PCaSCs) and an immunosuppressive microenvironment. <b>Methods:</b> A CD44-targeted nanoactivator (... |
41510155 | Stimuli-responsive hydrogels based on cascade reactions: a novel strategy to promote the efficient repair of diabetic wounds. | The impaired healing of diabetic wounds is caused by complex multifactorial pathologies and conventional therapeutic approaches often show limited efficacy. In recent years, stimulus-responsive hydrogels based on cascade reactions have become a promising approach in the management of diabetic wounds. These hydrogels ar... |
41510154 | Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis. | <b>Rationale:</b> Temporal lobe epilepsy (TLE) is a prevalent, drug-resistant neurological disorder that causes severe disability, highlighting the need to identify novel therapeutic targets. Emerging evidence reveals widespread transcriptional dysregulation during epileptogenesis, in which multiple dysregulated genes ... |
41508736 | VAMP7-mediated autophagy regulates cervical cancer progression associated with persistent HPV16 infection. | <h4>Backgroud</h4>Persistent infection with high-risk human papillomavirus type 16 (HPV16) is a principal etiological factor in cervical cancer. Nevertheless, the molecular events linking HPV16-associated lesion progression to malignant transformation remain insufficiently characterized, particularly those involving ve... |
41508695 | Expanding the Therapeutic Potential of NUIG4: A Multifunctional Metal-Organic Framework for Dual Anticancer and Antibacterial Drug Delivery. | Metal-organic frameworks (MOFs) have emerged as highly tunable materials for targeted and controlled drug delivery. In this study, NUIG4 is presented as a multifunctional MOF-based carrier capable of encapsulating both anticancer and antimicrobial therapeutics. NUIG4 exhibits high-surface area, water stability, and sui... |
41508542 | From Liposomes to Virosomes: Evolution of Phospholipid Nanocarriers in Drug Delivery. | Phospholipid-based nanocarriers are an adaptable and chemically tunable class of drug delivery systems that self-assemble into bilayered vesicles due to the amphiphilic nature of phospholipids. Phospholipid-based nanocarriers can encapsulate both hydrophilic and hydrophobic drugs through non-covalent interactions and m... |
41507108 | Thiazolidine-Grafted Zeolite Imidazolate Frameworks: A Cysteine-Derived Route to Improved Metal Loading and Tune the CO<sub>2</sub> Hydrogenation Efficiency. | Covalent grafting of S-containing ligands onto a zeolitic imidazolate framework (ZIF) can create a material with enhanced metal capture capabilities. This is achieved by forming thiazolidine groups from the condensation of aldehyde groups from the imidazole linker with cysteine, which can act as binding sites for noble... |
41505096 | Sequence-dependent co-condensation of Lsr2 with DNA elucidates the mechanism of genome compaction in Mycobacterium tuberculosis. | The xenogeneic silencer protein Lsr2 from Mycobacterium tuberculosis plays a critical role in its survival and pathogenesis. Lsr2 is a nucleoid-associated protein (NAP) that interacts with DNA in vivo and regulates many genes. Purified Lsr2 forms nucleoprotein filaments with DNA molecules, leading to highly compacted D... |
41504333 | Molecular foundations of collagen triple helical assembly: the central role of prolyl-4-hydroxylation. | Collagen, the principal structural protein of the extracellular matrix, has been pivotal in the evolution of multicellular life. Among its posttranslational modifications (PTMs), prolyl-4-hydroxylation stands out as the most conserved and functionally critical. This hydroxylation not only facilitates polyproline II-lik... |
41504263 | Statistical mechanical theory and computational study on thermodynamic stability of clathrate hydrates. | Clathrate hydrates are non-stoichiometric inclusion compounds with critical relevance to energy resources and CO2 sequestration, formed by guest molecules encapsulated in water cages. This perspective overviews the synergistic progress achieved through statistical mechanics and molecular simulation with intermolecular ... |
41504013 | Targeting the TRIM28-EZH2 Protein-Protein Interface With Cysteine-Reactive Covalent Inhibitors: A Computational Blueprint for Cancer Therapy. | Aberrant protein-protein interactions (PPIs) play crucial roles in cancer progression by driving transcriptional repression and epigenetic silencing. Among these, the TRIM28-EZH2 interaction is central to maintaining repressive chromatin states that promote tumorigenesis. In this study, we modeled the TRIM28-EZH2 compl... |
41503920 | Antiurolithiatic Potential of a Series of Phthalimide Derivatives on Calcium Oxalate Crystals. | Urolithiasis, primarily caused by calcium oxalate crystals, represents a major health concern due to high recurrence rates and limitations of current treatments in dissolving existing stones. This study investigated the antiurolithiatic potential of 15 phthalimide derivatives against calcium oxalate monohydrate (COM) a... |
41502161 | A Comprehensive Review on the Structure, Formation, and Multidimensional Characterization of Starch-Guest Inclusion Complexes. | Starch inclusion complexes (ICs) have a crucial influence on food processing and human health by reducing the rate of enzymatic digestion and maintaining glucose homeostasis, offering benefits for individuals suffering from type 2 diabetes. Therefore, starch ICs have become a promising approach in the fields of food sc... |
41500845 | From Molecule to Meaning: Neuronopathic Biomarkers and Clinical Relevance in GM1. | GM1 gangliosidosis is a rare, progressively neurodegenerative lysosomal storage disorder characterized by profound central nervous system involvement and substantial clinical heterogeneity. The development of reliable biomarkers is essential for tracking disease progression, stratifying patients, and advancing clinical... |
41499312 | Molecular Variations in Glycoprotein B of Asian Human Cytomegalovirus: Potential Impact on Virus Entry and Immune Evasion in Ocular Diseases. | Human cytomegalovirus (HCMV)-associated ocular diseases have gained increasing attention due to a recent rise in cases diagnosed in Asia. A glycoprotein encoded by the virus UL55 gene, glycoprotein B (gB), is essential for viral entry and a primary target for naturally-produced antibodies and vaccine development. gB is... |
41496404 | Multiscale mechanistic insights into sonochemical energy coupling and flavor evolution in Pu‑erh tea. | Pu'erh tea (Camellia sinensis var. assamica) represents a highly complex multiphase fermentation system in which flavor formation spans chemical transformation, energy transfer and microecological succession. To elucidate the mechanistic basis by which sonochemical energy input accelerates flavor evolution, we develope... |
41496108 | Recurarization after sugammadex reversal in a patient with amyotrophic lateral sclerosis: Case report. | <h4>Rationale</h4>Amyotrophic lateral sclerosis (ALS) confers heightened and unpredictable sensitivity to nondepolarizing neuromuscular blocking agents and a high risk of postoperative respiratory failure. Although sugammadex reliably reverses rocuronium, recurarization may occur and is likely under-recognized in ALS. ... |
41495908 | Specificity of the stabilizing interaction between intrinsically disordered protein sequences and G-quadruplexes in RNA. | Intrinsically disordered regions (IDRs) are present in and essential for the function of nearly all the proteins involved in regulation, cell, and developmental processes. The RGG domain in IDRs binds 'promiscuously' to RNA G-quadruplexes (rG4s), a non-canonical 4-stranded secondary structure that occurs in many transc... |
41495894 | Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition. | Some prokaryotes carry CRISPR-associated transposons (CASTs), Tn7-like elements that incorporate genes encoding CRISPR-Cas effectors. CAST insertion is directed by CRISPR-Cas effectors through RNA-guided DNA binding and interactions with transposition-associated proteins. Although efficient sequence-specific DNA integr... |
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