Entry stringlengths 6 10 | Entry Name stringlengths 5 11 | Sequence stringlengths 2 35.2k | EC number stringlengths 7 118 ⌀ | Cofactor stringlengths 38 1.77k ⌀ | Gene Ontology (biological process) stringlengths 18 11.3k ⌀ | Gene Ontology (cellular component) stringlengths 17 1.75k ⌀ | Gene Ontology (molecular function) stringlengths 24 2.09k ⌀ | Pfam stringlengths 8 232 ⌀ | Gene3D stringlengths 10 250 ⌀ | Protein families stringlengths 9 237 ⌀ | Post-translational modification stringlengths 16 8.52k ⌀ | Subcellular location [CC] stringlengths 29 6.18k ⌀ | Catalytic activity stringlengths 64 35.7k ⌀ | Kinetics stringlengths 69 11.7k ⌀ | Pathway stringlengths 27 908 ⌀ | pH dependence stringlengths 64 955 ⌀ | Temperature dependence stringlengths 70 1.16k ⌀ | Function [CC] stringlengths 17 15.3k ⌀ | Organism stringlengths 8 196 |
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P0CG53 | UBB_BOVIN | MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC | null | null | modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567] | cytosolic small ribosomal subunit [GO:0022627]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634] | protein tag activity [GO:0031386]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625] | PF00240; | null | Ubiquitin family | PTM: [Ubiquitin]: Phosphorylated at Ser-65 by PINK1 during mitophagy (PubMed:26116755). Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:26116755). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form poly... | SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P0CG47}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0CG47}. | null | null | null | null | null | FUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored) (By similarity). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or... | Bos taurus (Bovine) |
P0CG56 | PA2BB_CRODU | HLLQFNKMIKFETRKNAVPFYAFYGCYCGWGGQGRPKDATDRCCFVHDCCYGKLAKCNTKWDIYRYSLKSGYITCGKGTWCEEQICECDRVAAECLRRSLSTYKNGYMFYPDSRCRGPSETC | 3.1.1.4 | COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250|UniProtKB:P62022}; Note=Binds 1 Ca(2+) ion. {ECO:0000250|UniProtKB:P62022}; | arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phospholipid metabolic process [GO:0006644] | extracellular region [GO:0005576] | calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; ion channel regulator activity [GO:0099106]; phospholipid binding [GO:0005543]; toxin activity [GO:0090729] | PF00068; | 1.20.90.10; | Phospholipase A2 family, Group II subfamily, D49 sub-subfamily | null | SUBCELLULAR LOCATION: Secreted. | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.07 uM for 1-palmitoyl-2-(10-pyrenyldecanoyl)-sn-glycero-3-monomethyl phosphatidic acid (monomer CBb) {ECO:0000269|PubMed:8513799}; KM=0.3 uM for 1-palmitoyl-2-(10-pyrenyldecanoyl)-sn-glycero-3-monomethyl phosphatidic acid (class 2 heterodimer CA2-CBb) {ECO:000026... | null | null | null | FUNCTION: Heterodimer CA-CB: Crotoxin is a potent presynaptic neurotoxin that possesses phospholipase A2 (PLA2) activity and exerts a lethal action by blocking neuromuscular transmission. It consists of a non-covalent association of a basic and weakly toxic PLA2 subunit (CBa2, CBb, CBc, or CBd), with a small acidic, no... | Crotalus durissus terrificus (South American rattlesnake) |
P0CG57 | PA2HC_OXYSC | NLVQFGFMIECAIRNRRPALDFMNYGCYCGTVGRGTPVDDLDRCCQVHDECYATAEKHGCYPSLTTYQWECRQVGNECNSKTQCEVFVCACDLAAAKCLAQEDYNPAHFNINTGERCK | null | null | arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] | extracellular region [GO:0005576] | calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543] | PF00068; | 1.20.90.10; | Phospholipase A2 family, Group I subfamily, D49 sub-subfamily | null | SUBCELLULAR LOCATION: Secreted. | null | null | null | null | null | FUNCTION: Heterotrimer: Snake venom phospholipase A2 (PLA2) heterotrimer that acts as a potent presynaptic neurotoxin by blocking synaptic transmission and synaptic vesicle recycling. May act by binding in a calcium-dependent fashion to neurotonal pentraxin-1 (NPTX1) and neurotonal pentraxin-2 (NPTX2), but not to neuro... | Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan) |
P0CG63 | UBI4P_YEAST | MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLE... | null | null | modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567] | cytosol [GO:0005829]; nucleus [GO:0005634] | protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625] | PF00240; | null | Ubiquitin family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250|UniProtKB:Q15843}. | null | null | null | null | null | FUNCTION: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer l... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CH08 | RL40A_YEAST | MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCDKSVCRKCYARLPPRATNCRKRKCGHTNQLRPKKKLK | null | null | cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit export from nucleus [GO:0000055]; ribosome biogenesis [GO:0042254] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; nucleus [GO:0005634] | protein tag activity [GO:0031386]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625] | PF01020;PF00240; | 4.10.1060.50; | Ubiquitin family; Eukaryotic ribosomal protein eL40 family | null | SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Large ribosomal subunit protein eL40A]: Cytoplasm {ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polyme... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CH09 | RL40B_YEAST | MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCDKSVCRKCYARLPPRATNCRKRKCGHTNQLRPKKKLK | null | null | cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit export from nucleus [GO:0000055]; ribosome biogenesis [GO:0042254] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | protein tag activity [GO:0031386]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625] | PF01020;PF00240; | 4.10.1060.50; | Ubiquitin family; Eukaryotic ribosomal protein eL40 family | null | SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Large ribosomal subunit protein eL40B]: Cytoplasm {ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polyme... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CH24 | CA1_CONAH | LGVLVTIFLVLFPMATLQLDGDQTADRHAGERDQDPLEQYRNLKHVLRRTRNYYLYPARPENSWWT | null | null | null | extracellular region [GO:0005576]; host cell postsynaptic membrane [GO:0035792] | ion channel regulator activity [GO:0099106]; toxin activity [GO:0090729] | null | null | Conotoxin A superfamily | PTM: Ac1-O6P is hydroxylated once at Pro-60, whereas Ac1 is hydroxylated at both Pro-57 and Pro-60. Trp-64 is supposed to be a D-amino acid in Ac1-O6P. {ECO:0000269|PubMed:32111068}.; PTM: Hydroxylation at Pro-57 is important for activity on N-methyl-D-aspartate receptors, since Ac1 is 5-fold more potent than Ac1 on NR... | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32111068}. | null | null | null | null | null | FUNCTION: Ac1 weakly inhibits N-methyl-D-aspartate receptor subunit 2B (NR2B) (IC(50)=8.22 uM). In vivo, shortens sleep latency and extends sleep time after lateral brain administration. Is more potent than Ac1-O6P for these effects. Also has an analgesic activity similar to that of Ac1-O6P. {ECO:0000269|PubMed:3211106... | Conus achatinus (Little frog cone) |
P0CH38 | FBSP1_RAT | LASRALVCKHWYRCLHGDENSEVWRSLCARSLEEAMRTDILCNLPSYKAKVRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKACLYPAVSAVYGNTEVTLVYLGKPLDG | null | null | anterior commissure morphogenesis [GO:0021960]; cerebral cortex radially oriented cell migration [GO:0021799]; cerebral cortex tangential migration [GO:0021800]; corticospinal tract morphogenesis [GO:0021957]; DNA damage response [GO:0006974]; innervation [GO:0060384]; neuron migration [GO:0001764]; proteasome-mediated... | cell projection [GO:0042995]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic cytosol [GO:0099523]; presynaptic membrane [GO:0042734... | ubiquitin ligase-substrate adaptor activity [GO:1990756] | PF00622; | 2.60.120.920; | FBXO45/Fsn family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C2W1}. Postsynaptic cell membrane {ECO:0000269|PubMed:19996097}. Presynaptic cell membrane {ECO:0000269|PubMed:19996097}. Nucleus {ECO:0000250|UniProtKB:P0C2W1}. Note=Secreted by a non-classical mechanism. {ECO:0000250|UniProtKB:P0C2W1}. | null | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P0C2W1}. | null | null | FUNCTION: Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1. Functions in substrate recognition but plays also an important role in assembly of the complex (By similarity). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Regulates n... | Rattus norvegicus (Rat) |
P0CH90 | NA237_NEMVE | MASFKIVIVCLALLVAVASARRRDMMSDDELDYHYSKRGIPCACDSDGPDIRSASLSGIVWMGSCPSGWKKCKSYYSIVADCCNQ | null | null | null | extracellular region [GO:0005576] | sodium channel regulator activity [GO:0017080]; toxin activity [GO:0090729] | PF00706; | 2.20.20.10; | Sea anemone sodium channel inhibitory toxin family, Type II subfamily | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18538344}. | null | null | null | null | null | FUNCTION: Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process (PubMed:18538344). Is highly active on DmNav1/TipE (drosophila) and is only extremely weakly active on rat Nav1.4-beta-1/SCN4A-SCN1B, and on human Nav1.5-beta-1/SCN5A-beta-1 (PubMed:18538344). This reveals high specificity ... | Nematostella vectensis (Starlet sea anemone) |
P0CH95 | PHF8_DANRE | MASVPVYCLCRLPYDVTRFMIECDVCQDWFHGSCVGVEEDKAAEIDLYHCPNCQVTHGPSVMRKRRGAVKHADVGLGRDSGRPVKTGSAQFVRELRCRTFPSADEVLLKPTGAQLTVEFLEERSFSVPVLVLRKDGLGMNLPPSSFSVTDVEHYIGTEKEIDVIDVSRQADLKMKLGEFVEYYNSPNRDRVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEESIFERPNVQKYCLMGVKDSYTDFHIDFGGTSVWYHVLRGEKIFYLIRPTAANLSLFERWSSSSNQNELFFGDQVDMCYKCSVKQGNTLFIPTG... | 1.14.11.27; 1.14.11.65 | COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250}; | brain development [GO:0007420]; embryonic viscerocranium morphogenesis [GO:0048703]; G1/S transition of mitotic cell cycle [GO:0000082]; inner ear morphogenesis [GO:0042472]; negative regulation of rDNA heterochromatin formation [GO:0061188]; positive regulation of DNA-templated transcription [GO:0045893]; positive reg... | nucleolus [GO:0005730] | chromatin binding [GO:0003682]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 deme... | PF17811;PF02373;PF00628; | 1.20.58.1360;2.60.120.650; | JHDM1 histone demethylase family, JHDM1D subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis (By similarity). {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:42032, Rhea:RHEA-COMP:9785, Rhea:RHEA-COMP:9787, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29... | null | null | null | null | FUNCTION: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated his... | Danio rerio (Zebrafish) (Brachydanio rerio) |
P0CI65 | NPHP3_DANRE | MGTASSLVSPGEVIEDAYGGEGGEACEIPVEVKPKARLLRSSFRRGPRVIGASFKSTGSVELEYAAEYERLRKDYEIFRVSKNNEITSMQKKEAKLDEENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKEKEIQDLLRAKRDLESKLQQLQAQGIQIYDPADSDSDDNHTTVTTAGTQCEYWSGGVLGSEPSMGSMMQLQQTHRGPEFAHSLIDVEGPFANVSRDDWDAAVASLLQVSPHVSQSLWSNTVRCYLIYTHETKAELQTFIQTYSLRLRRFCEGLGHFYLNVSFPE... | null | null | cilium assembly [GO:0060271]; convergent extension [GO:0060026]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; kidney development [GO:0001822]; Kupffer's vesicle development [GO:0070121]; left/right pattern formation [GO:0060972]; pronephros development [GO:0048793]; visual perception [... | ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929] | null | PF13424;PF13176; | 3.40.50.300;1.25.40.10; | null | null | SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. | null | null | null | null | null | FUNCTION: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Require... | Danio rerio (Zebrafish) (Brachydanio rerio) |
P0CJ46 | ACT1_ARATH | MADGEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVNNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNAPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDALMKILTERGYSFTTTAEREIVRDIKEKLCYIALDYEQELETAKTSSSVEKNYELPDGQVITIGSERFRCPEVLYQPSMIGMENAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFPGIADRMSKEIT... | 3.6.4.- | null | developmental growth [GO:0048589]; root hair elongation [GO:0048767] | cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plant-type cell wall [GO:0009505]; plasma membrane [GO:0005886]; plasmodesma [GO:0009506] | ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] | PF00022; | 3.30.420.40; | Actin family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P68137}; | null | null | null | null | FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension... | Arabidopsis thaliana (Mouse-ear cress) |
P0CJ48 | CB1A_ARATH | MAASTMALSSPAFAGKAVNLSPAASEVLGSGRVTMRKTVAKPKGPSGSPWYGSDRVKYLGPFSGESPSYLTGEFPGDYGWDTAGLSADPETFARNRELEVIHSRWAMLGALGCVFPELLARNGVKFGEAVWFKAGSQIFSDGGLDYLGNPSLVHAQSILAIWATQVILMGAVEGYRVAGNGPLGEAEDLLYPGGSFDPLGLATDPEAFAELKVKELKNGRLAMFSMFGFFVQAIVTGKGPIENLADHLADPVNNNAWAFATNFVPGK | null | COFACTOR: Note=Binds at least 14 chlorophylls (8 Chl-a and 6 Chl-b) and carotenoids such as lutein and neoxanthin. {ECO:0000250}; | photosynthesis, light harvesting in photosystem I [GO:0009768]; response to fructose [GO:0009750]; response to light stimulus [GO:0009416] | apoplast [GO:0048046]; chloroplast envelope [GO:0009941]; chloroplast thylakoid membrane [GO:0009535]; nucleus [GO:0005634]; photosystem I [GO:0009522]; photosystem II [GO:0009523]; plastoglobule [GO:0010287]; thylakoid [GO:0009579] | chlorophyll binding [GO:0016168]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729] | PF00504; | 1.10.3460.10; | Light-harvesting chlorophyll a/b-binding (LHC) protein family | PTM: Photoregulated by reversible phosphorylation of its threonine residues. {ECO:0000250}. | SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. | null | null | null | null | null | FUNCTION: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. | Arabidopsis thaliana (Mouse-ear cress) |
P0CJ62 | RITA1_XENLA | MPDNLYATNMSLDLSITGHSTALPQRKSRSTYRFKAANSYVDESLFGSSGVRVDQTLQWNTAPPSQTPLLWSPGEIKENKKTSSCRPKSTPAGTPRKKIQYRVKSRTPSYCDESLFGGKVEECTWDAPWVKKEDTVKIRPLLWSPSPRLVQQSSMQNAKQGPLRAVHPPETSDSPLGTHKGLGAFWKPPESDSDYSPSPFSARQRQSTPGRETVRSASCSGRVTARRGSVKMQERPPWK | null | null | negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | tubulin binding [GO:0015631] | PF17066; | null | RITA family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21102556}. Nucleus {ECO:0000269|PubMed:21102556}. Note=Shuttles rapidly between the cytoplasm and the nucleus. | null | null | null | null | null | FUNCTION: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of rbpj/rbpsuh, thereby preventing the interaction between rbpj/rbpsuh and NICD product of Notch proteins (Notch intracellular domain), leading t... | Xenopus laevis (African clawed frog) |
P0CJ63 | AHLLA_BACTK | MTVKKLYFIPAGRCMLDHSSVNSALTPGKLLNLPVWCYLLETEEGPILVDTGMPESAVNNEGLFNGTFVEGQILPKMTEEDRIVNILKRVGYEPDDLLYIISSHLHFDHAGGNGAFTNTPIIVQRTEYEAALHREEYMKECILPHLNYKIIEGDYEVVPGVQLLYTPGHSPGHQSLFIETEQSGSVLLTIDASYTKENFEDEVPFAGFDPELALSSIKRLKEVVKKEKPIIFFGHDIEQEKSCRVFPEYI | 3.1.1.81 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:16087890, ECO:0000269|PubMed:16314577}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000269|PubMed:16087890, ECO:0000269|PubMed:16314577}; | null | null | acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; metal ion binding [GO:0046872] | PF00753; | 3.60.15.10; | Metallo-beta-lactamase superfamily | null | null | CATALYTIC ACTIVITY: Reaction=an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+); Xref=Rhea:RHEA:22576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:55474, ChEBI:CHEBI:58921; EC=3.1.1.81; Evidence={ECO:0000269|PubMed:16314577}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=303 mM for GBL (with cobalt as cofactor) {ECO:0000269|PubMed:18627130}; KM=0.8 mM for C5-HSL (with cobalt as cofactor) {ECO:0000269|PubMed:18627130}; KM=0.15 mM for C10-HSL (with cobalt as cofactor) {ECO:0000269|PubMed:18627130}; KM=3.8 mM for BOC-HSL (with cobalt ... | null | null | null | FUNCTION: Catalyzes hydrolysis of N-hexanoyl-(S)-homoserine lactone, but not the R-enantiomer. Hydrolyzes short- and long-chain N-acyl homoserine lactones with or without 3-oxo substitution at C3, has maximum activity on C10-AHL. {ECO:0000269|PubMed:16314577}. | Bacillus thuringiensis subsp. kurstaki |
P0CK09 | MVP_TEV | MALIFGTVNANILKEVFGGARMACVTSAHMAGANGSILKKAEETSRAIMHKPVIFGEDYITEADLPYTPLHLEVDAEMERMYYLGRRALTHGKRRKVSVNNKRNRRRKVAKTYVGRDSIVEKIVVPHTERKVDTTAAVEDICNEATTQLVHNSMPKRKKQKNFLPATSLSNVYAQTWSIVRKRHMQVEIISKKSVRARVKRFEGSVQLFASVRHMYGERKRVDLRIDNWQQETLLDLAKRFKNERVDQSKLTFGSSGLVLRQGSYGPAHWYRHGMFIVRGRSDGMLVDARAKVTFAVCHSMTHYSDKSISEAFFIPYSKK... | 3.4.-.-; 3.4.22.45 | null | proteolysis [GO:0006508]; transport of virus in host, cell to cell [GO:0046740]; virus-mediated perturbation of host defense response [GO:0019049] | host cell plasmodesma [GO:0044219] | cysteine-type endopeptidase activity [GO:0004197]; serine-type peptidase activity [GO:0008236] | PF00851;PF01577;PF13608; | 3.90.70.150; | Potyviridae P3N-PIPO polyprotein family | PTM: Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO is cleaved by P1 and HC-pro proteinases resulting in the production... | SUBCELLULAR LOCATION: Host cell junction, host plasmodesma {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.; EC=3.4.22.45; | null | null | null | null | FUNCTION: [Helper component proteinase]: Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a m... | Tobacco etch virus (TEV) |
P0CK11 | MVP_TUMVJ | MAAVTFASAITNAITSKPALTGMVQFGSFPPMPLRSTTVTTVATSVAQPKLYTVQFGSLDPVVVKSGAGSLAKATRQQPNVEIDVSLSEAAALEVAKPRSNAVLRMHEEANKERALFLDWEASLKRSSYGIAEDEKVVMTTHGVSKIVPRSSRAMKLKRARERRRAQQPIILKWEPKLSGISIGGGLSASVIEAEEVRTKWPLHKTPSMKKRTVHRICKMNDQGVDMLTRSLVKIFKTKSANIEYIGKKSIKVDFIRKERTKFARIQVAHLLGKRAQRDLLTGMEENHFIDILSKYSGNKTTINPGVVCAGWSGIVVGNG... | 3.4.-.-; 3.4.22.45 | null | proteolysis [GO:0006508]; transport of virus in host, cell to cell [GO:0046740]; virus-mediated perturbation of host defense response [GO:0019049] | host cell plasmodesma [GO:0044219] | cysteine-type endopeptidase activity [GO:0004197]; serine-type peptidase activity [GO:0008236] | PF00851;PF01577;PF13608; | 3.90.70.150; | Potyviridae P3N-PIPO polyprotein family | PTM: Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO is cleaved by P1 and HC-pro proteinases resulting in the production... | SUBCELLULAR LOCATION: Host cell junction, host plasmodesma {ECO:0000269|PubMed:18408156}. | CATALYTIC ACTIVITY: Reaction=Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.; EC=3.4.22.45; Evidence={ECO:0000255|PROSITE-ProRule:PRU01080}; | null | null | null | null | FUNCTION: [Helper component proteinase]: Cysteine protease that cleaves a Gly-Gly dipeptide at its own C-terminus (By similarity). Required for aphid transmission and also has proteolytic activity (By similarity). Interacts with virions and aphid stylets (By similarity). Acts as a suppressor of RNA-mediated gene silenc... | Turnip mosaic virus (strain Japanese) (TuMV) |
P0CL69 | ZN703_MOUSE | MSDSPAGSNPRTPESSGSGGGSSSGGGGGKRPAVPAVVSLLPPADPLRQANRLPIRVLKMLSAHTGHLLHPEYLQPLSSTPVSPIELDAKKSPLALLAQTCSQIGKPDPPPSSKLNSVAAAAANGLGSEKDPSRSAPGAASAAAALKQLGDSPAEDKSSFKPYSKGSGGGDSRKDSGSSSVSSTTSSSSSSPGDKAGFRVPSAACPPFPPHGASVSTSSNSSSPGGSRGGSPHHSDCKNGGGGAGELDKKEQEAKPSPEPAAGSRGSGGDSAHGGPEATASGRKSEPPSALVGAGHVAPVSPYKPGHSVFPLPPSSIGYH... | null | null | adherens junction assembly [GO:0034333]; cellular response to estradiol stimulus [GO:0071392]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migrat... | cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872] | PF12402; | 3.30.160.60; | Elbow/Noc family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21317240}. Cytoplasm {ECO:0000269|PubMed:21317240}. | null | null | null | null | null | FUNCTION: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21... | Mus musculus (Mouse) |
P0CM22 | ARO1_CRYNJ | MSSSSADVLKISILGNESIHVGFHLLPYIFKTITTTLPSSTYVLITDTNLSAIYLNDFKASFEEAASEADNKARFLVYEVAPGEGAKSRKVKGEIEDWMLDNKCTRDTVILAFGGGVIGDLTGFVAATFMRGVKFVQIPTTLLAMVDSSVGGKTAIDTPHGKNLIGAFWQPSYIFVDLAFLTTLPTREVSNGMAEVIKTAAIWKDDDFALLESRSAEISLAASSRPTGVPTAGRFVSDRSHAQSLLLQVVSGSIYVKAHIVTIDERETGLRNLVNFGHTIGHAIEAVLTPAMLHGECVSVGIVLEAEVARQLGILSQVAV... | 1.1.1.25; 2.5.1.19; 2.7.1.71; 4.2.1.10; 4.2.3.4 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; | amino acid biosynthetic process [GO:0008652]; aromatic amino acid family biosynthetic process [GO:0009073]; chorismate biosynthetic process [GO:0009423]; phosphorylation [GO:0016310] | cytoplasm [GO:0005737] | 3-dehydroquinate dehydratase activity [GO:0003855]; 3-dehydroquinate synthase activity [GO:0003856]; 3-phosphoshikimate 1-carboxyvinyltransferase activity [GO:0003866]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; shikimate 3-dehydrogenase (NADP+) activity [GO:0004764]; shikimate kinase activity [GO:000476... | PF01761;PF01487;PF00275;PF18317;PF01488;PF08501;PF01202; | 3.40.50.1970;3.20.20.70;1.20.1090.10;3.65.10.10;3.40.50.10860;3.40.50.720;3.40.50.300; | Sugar phosphate cyclases superfamily, Dehydroquinate synthase family; EPSP synthase family; Shikimate kinase family; Type-I 3-dehydroquinase family; Shikimate dehydrogenase family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03143}. | CATALYTIC ACTIVITY: Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364, ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4; Evidence={ECO:0000255|HAMAP-Rule:MF_03143}; CATALYTIC ACTIVITY: Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; Xr... | null | PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. {ECO:0000255|HAMAP-Rule:MF_03143}.; PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: st... | null | null | FUNCTION: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03143}. | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
P0CM23 | ARO1_CRYNB | MSSSSADVLKISILGNESIHVGFHLLPYIFKTITTTLPSSTYVLITDTNLSAIYLNDFKASFEEAASEADNKARFLVYEVAPGEGAKSRKVKGEIEDWMLDNKCTRDTVILAFGGGVIGDLTGFVAATFMRGVKFVQIPTTLLAMVDSSVGGKTAIDTPHGKNLIGAFWQPSYIFVDLAFLTTLPTREVSNGMAEVIKTAAIWKDDDFALLESRSAEISLAASSRPTGVPTAGRFVSDRSHAQSLLLQVVSGSIYVKAHIVTIDERETGLRNLVNFGHTIGHAIEAVLTPAMLHGECVSVGIVLEAEVARQLGILSQVAV... | 1.1.1.25; 2.5.1.19; 2.7.1.71; 4.2.1.10; 4.2.3.4 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; | amino acid biosynthetic process [GO:0008652]; aromatic amino acid family biosynthetic process [GO:0009073]; chorismate biosynthetic process [GO:0009423]; phosphorylation [GO:0016310] | cytoplasm [GO:0005737] | 3-dehydroquinate dehydratase activity [GO:0003855]; 3-dehydroquinate synthase activity [GO:0003856]; 3-phosphoshikimate 1-carboxyvinyltransferase activity [GO:0003866]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; shikimate 3-dehydrogenase (NADP+) activity [GO:0004764]; shikimate kinase activity [GO:000476... | PF01761;PF01487;PF00275;PF18317;PF01488;PF08501;PF01202; | 3.40.50.1970;3.20.20.70;1.20.1090.10;3.65.10.10;3.40.50.10860;3.40.50.720;3.40.50.300; | Sugar phosphate cyclases superfamily, Dehydroquinate synthase family; EPSP synthase family; Shikimate kinase family; Type-I 3-dehydroquinase family; Shikimate dehydrogenase family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03143}. | CATALYTIC ACTIVITY: Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364, ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4; Evidence={ECO:0000255|HAMAP-Rule:MF_03143}; CATALYTIC ACTIVITY: Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; Xr... | null | PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. {ECO:0000255|HAMAP-Rule:MF_03143}.; PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: st... | null | null | FUNCTION: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03143}. | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
P0CP00 | MYO1_CRYNJ | MAPSKKAGKKGAVGGFLSGASKPQKVQKADWSEGFTKKKAAGVPDMTLLSTITNEAINDNLKVRFQNQEIYTYIAHVLISVNPFRDLGIYTNDVLNSYRGKNRLEMSPHVFAIAESAYYRMTTEKENQCVIISGESGAGKTEAAKRIMQYIAAVSGGAEGGGIEGIKEMVLATNPLLESFGCAKTLRNDNSSRHGKYLEIMFNGMGQPVGAQITNYLLEKNRVVGQIDDERDFHIFYQFTKGASAKMKEAFGLQGPEAYAYISRSGCLDVKSINDVSDFQETLRAMQVIGLTSDEQDSIFRILATILWLGNIDFVEGDDG... | null | null | actin cortical patch assembly [GO:0000147]; actin cortical patch localization [GO:0051666]; actin filament organization [GO:0007015]; endocytosis [GO:0006897]; mitotic cytokinesis [GO:0000281]; vesicle transport along actin filament [GO:0030050] | actin cortical patch [GO:0030479]; actin cytoskeleton [GO:0015629]; cell cortex of cell tip [GO:0051285]; cell tip [GO:0051286]; cytoplasm [GO:0005737]; mating projection tip [GO:0043332]; medial cortex [GO:0031097]; myosin I complex [GO:0045160]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; vesicle... | actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; microfilament motor activity [GO:0000146] | PF00063;PF06017;PF07653; | 1.10.10.820;1.20.5.4820;1.20.58.530;3.40.850.10;1.20.120.720;2.30.30.40; | TRAFAC class myosin-kinesin ATPase superfamily, Myosin family | PTM: Phosphorylation of the TEDS site (Ser-363) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity (By similarity). {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, actin patch {ECO:0000250}. | null | null | null | null | null | FUNCTION: Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting ... | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
P0CP02 | ESA1_CRYNJ | MSPSAPSTPHGRGSGSEPGTPAPSVAAGGSYTIDDVVPGVKIYVIKPLSNGQAEQRRAEILSTRPKPKPSAFAPPPPPNAPSPDPRDDTEYYVHYVEFNKRLDEWVGGSRLVLSKEMEWPKSKDEPKKKDRPAKAQPSKAPSRATGSPIPSDSLLKKAANKAAMAAGKATPGKAMPSSKLGKASKIGKAGKFPQKRKAKTEADTEAEEESNEDNDALGEEEDMDEDGDVTLITSDGAIDPSREVVAAPSNPRAAPQVFSKKQEIEKLRTSGSMTQSHSEISRVKNLNKLQIGKHEVETWYFSPYPIEYAHLPVLYICEFC... | 2.3.1.-; 2.3.1.48 | null | DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of heterochromatin formation [GO:0031453]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA poly... | NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]; Swr1 complex [GO:0000812] | chromatin binding [GO:0003682]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H4K16 acetyltransferase activity [GO:0046972]; metal ion binding [GO:0046872]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide crotonyltransferase activit... | PF01853;PF11717;PF17772; | 2.30.30.140;3.40.630.30;3.30.60.60;1.10.10.10; | MYST (SAS/MOZ) family | PTM: Autoacetylation at Lys-381 is required for proper function. {ECO:0000250|UniProtKB:Q08649}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O94446}. Chromosome {ECO:0000250|UniProtKB:O94446}. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs). {ECO:0000250|UniProtKB:O94446}. | CATALYTIC ACTIVITY: Reaction=acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]; Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000250|UniProtKB:O94446}; ... | null | null | null | null | FUNCTION: Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac ... | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
P0CP03 | ESA1_CRYNB | MSPSAPSTPHGRGSGSEPGTPAPSVAAGGSYTIDDVVPGVKIYVIKPLSNGQAEQRRAEILSTRPKPKPSAFAPPPPPNAPSPDPRDDTEYYVHYVEFNKRLDEWVGGSRLVLSKEMEWPKSKDEPKKKDRPAKAQPSKAPSRATGSPIPSDSLLKKAANKAAMAAGKATPGKAMPSSKLGKASKIGKAGKFPQKRKAKTEADTEAEEESNEDNDALGEEEDMDEDGDVTLITSDGAIDPSREVVAAPSNPRAAPQVFSKKQEIEKLRTSGSMTQSHSEISRVKNLNKLQIGKHEVETWYFSPYPIEYAHLPVLYICEFC... | 2.3.1.-; 2.3.1.48 | null | DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of heterochromatin formation [GO:0031453]; positive regulation of transcription by RNA polymerase II [GO:0045944] | NuA4 histone acetyltransferase complex [GO:0035267]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]; Swr1 complex [GO:0000812] | histone H3K4 acetyltransferase activity [GO:0044016]; histone H4K16 acetyltransferase activity [GO:0046972]; metal ion binding [GO:0046872]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide crotonyltransferase activity [GO:0140064]; transcription co... | PF01853;PF11717;PF17772; | 2.30.30.140;3.40.630.30;3.30.60.60;1.10.10.10; | MYST (SAS/MOZ) family | PTM: Autoacetylation at Lys-381 is required for proper function. {ECO:0000250|UniProtKB:Q08649}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O94446}. Chromosome {ECO:0000250|UniProtKB:O94446}. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs). {ECO:0000250|UniProtKB:O94446}. | CATALYTIC ACTIVITY: Reaction=acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]; Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000250|UniProtKB:O94446}; ... | null | null | null | null | FUNCTION: Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac ... | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
P0CP68 | HOG1_CRYNJ | MADFVKLSIFGTVFEVTTRYVDLQPVGMGAFGLVCSAKDQLSGTSVAIKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSTGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTIASENTLRFVQSLPKREKVPFSTKFPNADPVSLDLLEKMLVFDPRTRISAAEGLAHEYLAPYHDPTDEPVAAEVFDWSFN... | 2.7.11.24 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; | cellular response to oxidative stress [GO:0034599]; osmosensory signaling pathway [GO:0007231]; phosphorylation [GO:0016310]; stress-activated MAPK cascade [GO:0051403] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069; | 1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family, MAP kinase subfamily. HOG1 sub-subfamily | PTM: Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme (By similarity). Phosphorylated by PBS2 after osmotic stress. {ECO:0000250, ECO:0000269|PubMed:15728721, ECO:0000269|PubMed:16514140}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15728721}. Nucleus {ECO:0000269|PubMed:15728721}. Note=Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[p... | null | null | null | null | FUNCTION: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Also involved in response UV radiations and mediates the sensitivity to fludioxonil, an agri... | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
P0CP70 | ATG1_CRYNJ | MPDSNAQGSREKESGHHRSHKERIGNYVVGAEIGRGSFATVYKGYRSKTRVPIAIKAVSRQKLTSKLLENLESEINILKVINHRNIVALTDCFKNDTHIYLVMEYCSGSDLSVYIKQRGNIPTLDFVPKAGSSMALLPTDDEGKIYWPHPPTGGLDERVTRSFLGQLAQAIKFLRAQDLMHRDIKPQNLLLQPATETEVAEGHPYGIPVLKVADFGFARILPAAAMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLFEMSVGRPPFRANNHVELLRRIEKSNDNIVFPDEKERDSKSSDETSIPVPSDIKALIRAL... | 2.7.11.1 | null | autophagosome assembly [GO:0000045]; axon extension [GO:0048675]; negative regulation of collateral sprouting [GO:0048671]; phosphorylation [GO:0016310]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; protein transport [GO:0015031]; regulation of autophagy [GO:00105... | autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] | ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF12063;PF21127;PF07714; | 1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P53104}. Preautophagosomal structure membrane {ECO:0000250|UniProtKB:P53104}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53104}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P53104}; CATALYTI... | null | null | null | null | FUNCTION: Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective a... | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
P0CS16 | UBC2_CRYNJ | MSTAAKRRLIRDFKRLTSDAPIGISGSPNPDNIMVWNAVIFGPPETPFEDGSFRLTLTFTDAYPNKPPTVRFISKMFHPNIYANGELCLDILQNRWSPTYDVAAILTSVQSLLNDPNPASPANVDAAQLFKENLKEYERRVKKTVELSWVDNADEIEAEVVEADEGSSS | 2.3.2.23 | null | cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; DNA repair [GO:0006281]; DNA-templated transcription termination [GO:0006353]; double-strand break repair via homologous recombination [GO:0000724]; ERAD pathway [GO:0036503]; error-free postreplication DNA repair [GO:0042275]; error-fre... | chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; HULC complex [GO:0033503]; MUB1-RAD6-UBR2 ubiquitin ligase complex [GO:1990304]; nucleus [GO:0005634]; Rad6-Rad18 complex [GO:0097505]; RAD6-UBR2 ubiquitin ligase complex [GO:1990305]; UBR1-RAD6 ubiquitin ligase complex [GO:1990303] | ATP binding [GO:0005524]; proteasome binding [GO:0070628]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]; ubiquitin conjugating enzyme activity [GO:0061631] | PF00179; | 3.10.110.10; | Ubiquitin-conjugating enzyme family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5VVX9}. Nucleus {ECO:0000250|UniProtKB:Q5VVX9}. | CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROS... | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. | null | null | FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formati... | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
P0CS17 | UBC2_CRYNB | MSTAAKRRLIRDFKRLTSDAPIGISGSPNPDNIMVWNAVIFGPPETPFEDGSFRLTLTFTDAYPNKPPTVRFISKMFHPNIYANGELCLDILQNRWSPTYDVAAILTSVQSLLNDPNPASPANVDAAQLFKENLKEYERRVKKTVELSWVDNADEIEAEVVEADEGSSS | 2.3.2.23 | null | cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; DNA-templated transcription termination [GO:0006353]; double-strand break repair via homologous recombination [GO:0000724]; ERAD pathway [GO:0036503]; error-free postreplication DNA repair [GO:0042275]; error-free translesion synthesis [... | chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; HULC complex [GO:0033503]; MUB1-RAD6-UBR2 ubiquitin ligase complex [GO:1990304]; nucleus [GO:0005634]; Rad6-Rad18 complex [GO:0097505]; RAD6-UBR2 ubiquitin ligase complex [GO:1990305]; UBR1-RAD6 ubiquitin ligase complex [GO:1990303] | ATP binding [GO:0005524]; proteasome binding [GO:0070628]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]; ubiquitin conjugating enzyme activity [GO:0061631] | PF00179; | 3.10.110.10; | Ubiquitin-conjugating enzyme family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5VVX9}. Nucleus {ECO:0000250|UniProtKB:Q5VVX9}. | CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROS... | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. | null | null | FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formati... | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
P0CS76 | SSN3_CRYNJ | MATIPGGGTIMDPMHLYRARRDKERRGVLKTYKILGFISSGTYGRVYKAVLLPPPKTASAKSALPSSTRAALSLPKDKLPSPSFTEDSDPLNNPEMCMRPGDRPAKRGDVFAIKKFKPDKEGDVLTYAGISQSGAREIMLNRELHHRNLVSLREVILEDKSIYMVFEYAEHDFLQIIHYHSQTARASIPPSTLRRLLHQLLCGVHFLHSNFVLHRDLKPANILVTSQGVVKIGDLGLARLWHKPLAQQGLYGGDKVVVTIWYRAPELILGAKHYTAAVDIWAVGCIYAELLSLRPIFKGDEAKMDGKKSLPFQRDQMGKI... | 2.7.11.22; 2.7.11.23 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; | negative regulation of filamentous growth [GO:0060258]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; phosphorylation [GO:0016310]; positive regulation of transcription from RNA polymerase II promoter by galactose [GO:000... | CKM complex [GO:1990508]; mediator complex [GO:0016592]; nucleus [GO:0005634] | ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] | PF00069; | 1.10.510.10; | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[p... | null | null | null | null | FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by ... | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
P0CS82 | HAP1_YEASX | MSNTPYNSSVPSIASMTQSSVSRSPNMHTATTPGANTSSNSPPLHMSSDSSKIKRKRNRIPLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRERVKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGSDEHTTLVNANTGSASSASHMHQQQQQQQQQEQQQDFSRSANANANSSSLSISNKYDNDELDLTKDFDLLHIKSNGTIHLGATHWLSIMKGDPYLKLLWGHIFAMREKLNEWYYQKNSYSKLKSSKCPINHAQAPPSAAAAATRKCPVDHSAFSSGMVAPKEETPL... | null | null | DNA-templated transcription [GO:0006351] | nucleus [GO:0005634] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] | PF00172; | 1.20.5.170;4.10.240.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:8182072}. | null | null | null | null | null | FUNCTION: Regulation of oxygen dependent gene expression. It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c. In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes. Binds to the sequence 5'-... | Saccharomyces cerevisiae (Baker's yeast) |
P0CS83 | CARP2_CANAX | MFLKNIFIALAIALLVDATPTTTKRSAGFVALDFSVVKTPKAFPVTNGQEGKTSKRQAVPVTLHNEQVTYAADITVGSNNQKLNVIVDTGSSDLWVPDVNVDCQVTYSDQTADFCKQKGTYDPSGSSASQDLNTPFKIGYGDGSSSQGTLYKDTVGFGGVSIKNQVLADVDSTSIDQGILGVGYKTNEAGGSYDNVPVTLKKQGVIAKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLIALPVTSDRELRISLGSVEVSGKTINTDNVDVLLDSGTTITYLQQDLADQIIKAFNGKLTQDSNGNSFYEVDCNLSGDVVF... | 3.4.23.24 | null | proteolysis [GO:0006508] | extracellular region [GO:0005576] | aspartic-type endopeptidase activity [GO:0004190]; metal ion binding [GO:0046872] | PF00026; | 2.40.70.10; | Peptidase A1 family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1447155, ECO:0000269|PubMed:8478090, ECO:0000269|PubMed:8845753}. | CATALYTIC ACTIVITY: Reaction=Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.; EC=3.4.23.24; Evidence={ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:... | null | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 4.0 using BSA or casein-resorufin as substrates, and 6.0-7.0, the pH of the saliva, for cleavage of Hst 5. {ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:0000269|PubMed:9043112}; | null | FUNCTION: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:11478679, PubMed:12761103, PubMed:15820985, PubMed:15845479, PubMed:19880183, PubMed:20713630, PubMed:22302440, PubMed:23927842). These enzymes supply the fungus with nutrient amino acids as we... | Candida albicans (Yeast) |
P0CS90 | HSP77_YEAST | MLAAKNILNRSSLSSSFRIATRLQSTKVQGSVIGIDLGTTNSAVAIMEGKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIGRRFEDAEVQRDIKQVPYKIVKHSNGDAWVEARGQTYSPAQIGGFVLNKMKETAEAYLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKSDSKVVAVFDLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLENDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHIN... | 3.6.4.10 | null | chaperone cofactor-dependent protein refolding [GO:0051085]; intracellular protein transport [GO:0006886]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial DNA metabolic process [GO:0032042]; negative regulation of mitochondrial translation [GO:0070130]; protein import into mitochondrial matrix [... | cytoplasm [GO:0005737]; endodeoxyribonuclease complex [GO:1905347]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; enzyme regulator activity [GO:0030234]; heat shock protein binding [GO:0031072]; mitochondrial protein-transporting ATPase activity [GO:0008566]; protein folding chaperone [GO:0044183]; unfolded protein... | PF00012; | 1.20.1270.10;3.30.420.40; | Heat shock protein 70 family | null | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:2265609}. | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10; Evidence={ECO:0000250|UniProtKB:Q05931}; | null | null | null | null | FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein. Required for the import of ... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CS91 | HSP77_YEASX | MLAAKNILNRSSLSSSFRIATRLQSTKVQGSVIGIDLGTTNSAVAIMEGKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIGRRFEDAEVQRDIKQVPYKIVKHSNGDAWVEARGQTYSPAQIGGFVLNKMKETAEAYLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKSDSKVVAVFDLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLENDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHIN... | 3.6.4.10 | null | null | cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759] | ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; hydrolase activity [GO:0016787]; unfolded protein binding [GO:0051082] | PF00012; | 1.20.1270.10;3.30.420.40; | Heat shock protein 70 family | null | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P0CS90}. | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10; Evidence={ECO:0000250|UniProtKB:Q05931}; | null | null | null | null | FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein. Required for the import of ... | Saccharomyces cerevisiae (Baker's yeast) |
P0CS93 | GAOA_GIBZA | MKHLLTLALCFSSINAVAVTVPHKAVGTGIPEGSLQFLSLRASAPIGSAISRNNWAVTCDSAQSGNECNKAIDGNKDTFWHTFYGANGDPKPPHTYTIDMKTTQNVNGLSMLPRQDGNQNGWIGRHEVYLSSDGTNWGSPVASGSWFADSTTKYSNFETRPARYVRLVAITEANGQPWTSIAEINVFQASSYTAPQPGLGRWGPTIDLPIVPAAAAIEPTSGRVLMWSSYRNDAFGGSPGGITLTSSWDPSTGIVSDRTVTVTKHDMFCPGISMDGNGQIVVTGGNDAKKTSLYDSSSDSWIPGPDMQVARGYQSSATMS... | 1.1.3.9 | COFACTOR: Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Note=Binds 1 Cu(2+) ion per subunit.; | null | extracellular region [GO:0005576] | galactose oxidase activity [GO:0045480]; metal ion binding [GO:0046872] | PF00754;PF09118;PF01344; | 2.130.10.80;2.60.120.260;2.60.40.10; | null | PTM: Galactose oxidase contains a protein-derived free radical cofactor. In the active state, Tyr-313, which is cross-linked to Cys-269 via a thioether bond, is oxidized to a radical and acts with Cu(2+) as a two-electron acceptor in the oxidation reaction. The cross-link is believed to modulate the redox potential of ... | SUBCELLULAR LOCATION: Secreted. | CATALYTIC ACTIVITY: Reaction=D-galactose + O2 = D-galacto-hexodialdose + H2O2; Xref=Rhea:RHEA:24160, ChEBI:CHEBI:4139, ChEBI:CHEBI:15379, ChEBI:CHEBI:16222, ChEBI:CHEBI:16240; EC=1.1.3.9; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=56 mM for 1-methyl-alpha-D-galactopyranoside {ECO:0000269|PubMed:15047910, ECO:0000269|PubMed:15239055, ECO:0000269|PubMed:17385891, ECO:0000269|PubMed:7929198, ECO:0000269|Ref.15}; KM=57 mM for 2-methylene-1,3-propanediol {ECO:0000269|PubMed:15047910, ECO:0000269|... | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7. Active from pH 5.7 to 9.4. {ECO:0000269|PubMed:15047910, ECO:0000269|PubMed:15239055, ECO:0000269|PubMed:17385891, ECO:0000269|PubMed:7929198, ECO:0000269|Ref.15}; | null | FUNCTION: Catalyzes the sterospecific oxidation of primary alcohols to the corresponding aldehydes. The biologically relevant substrate of the enzyme is not known as the enzyme exhibits broad substrate specificity from small alcohols through sugars to oligo- and polysaccharides. {ECO:0000269|PubMed:13641238, ECO:000026... | Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum) |
P0CT04 | IPB2_YEAST | MTKNFIVTLKKNTPDVEAKKFLDSVHHAGGSIVHEFDIIKGYTIKVPDVLHLNKLKEKHNDVIENVEEDKEVHTN | null | null | protein transport [GO:0015031]; regulation of proteolysis [GO:0030162]; vacuole fusion, non-autophagic [GO:0042144] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; fungal-type vacuole [GO:0000324]; membrane fusion priming complex [GO:0120124]; nucleus [GO:0005634] | endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867] | null | 3.30.70.80; | Protease inhibitor I9 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1100120, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:9159115}. | null | null | null | null | null | FUNCTION: Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis. PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. {ECO:0000269|P... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CT31 | EF1A1_DICDI | MGKEKTHINIVVIGHVDAGKSTTTGHLIYKCGGIDKRVIEKYEKEASEMGKQSFKYAWVMDKLKAERERGITIDIALWKFETSKYYFTIIDAPGHRDFIKNMITGTSQADCAVLVIASPTGEFEAGIAKNGQTREHALLAYTLGVKQMIVAINKMDEKSTNYSQARYDEIVKEVSSFIKKIGYNPEKVAFVPISGWNGDNMLERSDKMEWYKGPTLLEALDAIVEPKRPHDKPLRIPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPAGLSTEVKSVEMHHEQLPEARPGDNVGFNVKNVSVKEIKRGMVAGDSKND... | 3.6.5.- | null | actin filament bundle assembly [GO:0051017]; response to alkaline pH [GO:0010446]; response to bacterium [GO:0009617]; response to reactive oxygen species [GO:0000302]; sulfur compound metabolic process [GO:0006790]; translation [GO:0006412]; translational elongation [GO:0006414] | cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; phagocytic vesicle [GO:0045335]; pseudopodium [GO:0031143] | actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; calcium-dependent protein binding [GO:0048306]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] | PF00009;PF03144;PF03143; | 3.40.50.300;2.40.30.10; | TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily | null | SUBCELLULAR LOCATION: Cytoplasm. | CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence={ECO:0000250|UniProtKB:P68104}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000250|UniProtKB:P6810... | null | null | null | null | FUNCTION: Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing ... | Dictyostelium discoideum (Social amoeba) |
P0CT32 | EF1A2_DICDI | MGKEKTHINIVVIGHVDAGKSTTTGHLIYKCGGIDKRVIEKYEKEASEMGKQSFKYAWVMDKLKAERERGITIDIALWKFETSKYYFTIIDAPGHRDFIKNMITGTSQADCAVLVIASPTGEFEAGIAKNGQTREHALLAYTLGVKQMIVAINKMDEKSTNYSQARYDEIVKEVSSFIKKIGYNPEKVAFVPISGWNGDNMLERSDKMEWYKGPTLLEALDAIVEPKRPHDKPLRIPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPAGLSTEVKSVEMHHEQLPEARPGDNVGFNVKNVSVKEIKRGMVAGDSKND... | null | null | actin filament bundle assembly [GO:0051017]; response to alkaline pH [GO:0010446]; sulfur compound metabolic process [GO:0006790]; translation [GO:0006412]; translational elongation [GO:0006414] | cell cortex [GO:0005938]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; lipid droplet [GO:0005811]; phagocytic vesicle [GO:0045335]; pseudopodium [GO:0031143] | actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] | PF00009;PF03144;PF03143; | 3.40.50.300;2.40.30.10; | TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily | null | SUBCELLULAR LOCATION: Cytoplasm. | null | null | null | null | null | FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. It is also an abundant actin filament bundling protein. | Dictyostelium discoideum (Social amoeba) |
P0CT33 | TLH1_SCHPO | MVVASEIAKVASKTARDIAGCFTCQCGTQFDNVERIVQHFKECRYRDETCKDDDIVVYEPSSFVQDEKKDKPIIVEAASEATSEEACNSSKERQLPALSALSALSTLTTSANDDLWTARLIWQSTNDTKLDNSPSSNYTDLNHKLANYGLSILSIHALMCVECECLLNVIHTAQHMQIVHKLELNEDLLWFQELRTLKLKSPTNVLQTHSSQTHVYPYIRGLPVLLNGYECVPCTKNGTGFVHAIMDTFRHHVRRTHGKVIKLENCIRRTALQTVKNKYAQRCQFFKVDYVPLNGGEEEEEEEGEEKEDAQNIKERMVDF... | 5.6.2.4 | null | DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; telomere maintenance via recombination [GO:0000722] | chromosome [GO:0005694]; chromosome, telomeric repeat region [GO:0140445]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; replisome [GO:0030894] | 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; zinc ion binding [GO:0008270] | PF00270;PF00271; | 3.40.50.300; | Helicase family, RecQ subfamily | null | null | CATALYTIC ACTIVITY: Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.; EC=5.6.2.4; Evidence={ECO:0000305|PubMed:15591066}; CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:3061... | null | null | null | null | FUNCTION: A probable ATP-dependent 3'-5' DNA helicase (Probable) (PubMed:15591066). Has a role in telomerase-independent telomere maintenance (PubMed:15591066). {ECO:0000269|PubMed:15591066, ECO:0000305|PubMed:15591066}. | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
P0CT91 | LIPA_SODAL | MRLAPQKPLLLSTVLHLLLSIWMLGFASLAGATVQEPLAASDTPKPVSAALFSSIERLSRLVDITYCVGNTGVWKPFACASRCNEFPTLTLERTWRTGILMSDSCGLIAVDHGTPRHDAGEGKDDPLAEKAIIVAFRGTYSLTNTIIDLSTIPQEYVPYPSPDDGGNEPPREPSHRCDNCTVHSGFLASWRHARKVVLPELKVLRQKYPEYPIRLVGHSLGGAVAMLAALEMRVSLGWRDTVVTTFGEPRVGNRQLCDYLNAVFELNLGDEMDPAEREYRRVTHADDPVPLLPPAEWGYSSHGGEFFISKKDLPPSVEDV... | 3.1.1.3; 3.1.1.72 | null | lipid catabolic process [GO:0016042]; xylan catabolic process [GO:0045493] | extracellular region [GO:0005576] | acetylxylan esterase activity [GO:0046555]; triglyceride lipase activity [GO:0004806] | PF01764; | 3.40.50.1820; | AB hydrolase superfamily, Lipase family | PTM: Glycosylated. {ECO:0000269|PubMed:23915965}. | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=Deacetylation of xylans and xylo-oligosaccharides.; EC=3.1.1.72; Evidence={ECO:0000269|PubMed:23915965}; CATALYTIC ACTIVITY: Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.15 mM for p-nitrophenol acetate {ECO:0000269|PubMed:23915965}; KM=0.16 mM for p-nitrophenol butyrate {ECO:0000269|PubMed:23915965}; KM=0.1 mM for p-nitrophenol caprylate {ECO:0000269|PubMed:23915965}; KM=0.07 mM for p-nitrophenol myristate {ECO:0000269|PubMed:239... | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 8.0. {ECO:0000269|PubMed:23915965}; | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 40 degrees Celsius. Thermostable from 20 to 50 degrees Celsius. {ECO:0000269|PubMed:23915965}; | FUNCTION: Lipolytic enzyme that possesses both lipase and acetylxylan esterase activity. Active towards p-nitrophenol esters of various carbon chain length with preference for medium-chain fatty acids (C-8). Also highly active on the acetylated compounds xylose tetra-acetate and oat spelt xylan. {ECO:0000269|PubMed:239... | Sodiomyces alcalophilus (Acremonium alcalophilum) |
P0CT92 | MNLOX_NAKOS | MRIGLLAFAVAARYVEALPVASGEEVASSSAPTTLPSTSSSSALPSPTKYTLPHEDPNPEARKAEIALKRGGFLYGPSTLGQTTFYPSGTLGTAMSQRDQALWLRDAENQTITAYREANETLRDIQSHGGLKTLDDFALLYDGHWKASVPEGIEKGMLSNYTSDLLFSMERLSNNPYSLKRLHPTKDKLPFSVEDKVVKQLTATTLAALHKAGRLFFVDHSDQKKYTPQAGRYAAACQGLFYVDARSNQFLPLAIKTNVGADLTYTPLDDKNDWLLAKIMFNNNDLFYSQMYHVLFHTVPEIVHMAAIRTLSESHPVLAV... | 1.13.11.-; 1.13.11.45; 1.13.11.58 | COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:23233731}; Note=Three His residues, the carboxyl oxygen of the C-terminal Ile or Val residue, and a fifth residue, usually Asn, ligate the metal, which binds water to form a catalytic base Mn(2+)OH(2) for hydrogen abstraction. {ECO:0000250|UniP... | arachidonic acid metabolic process [GO:0019369]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372] | extracellular region [GO:0005576] | linoleate 11-lipoxygenase activity [GO:0050584]; linoleate 9S-lipoxygenase activity [GO:1990136]; metal ion binding [GO:0046872] | PF00305; | 3.10.450.60; | Lipoxygenase family, Manganese lipoxygenase subfamily | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23233731}. | CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate; Xref=Rhea:RHEA:30291, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:60955; EC=1.13.11.58; Evidence={ECO:0000269|PubMed:23233731}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy... | null | null | null | null | FUNCTION: Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 9S-, 11- and 13R-hydroperoxy fatty acids. At the end of lipoxygenation, the intermediate products 11S-HPODE and 13R-HPODE from linoleic acid are then transformed into 9S-HPODE as the final product. The intermediate product 11R-HPOTrE from alp... | Nakataea oryzae (Rice stem rot fungus) (Magnaporthe salvinii) |
P0CU34 | TSA1B_CANAL | MAPVVQQPAPSFKKTAVVDGVFEEVTLEQYKGKWVLLAFIPLAFTFVCPSEIIAYSEAVKKFAEKDAQVLFASTDSEYTWLAWTNVARKDGGIGKVDFPVLADTNHSLSRDYGVLIEEEGVALRGIFLIDPKGVLRQITINDLPVGRSVEESLRLLEAFQFTEKYGEVCPANWHPGDETIKPSPEASKEYFNKVNK | 1.11.1.24 | null | cell redox homeostasis [GO:0045454]; hydrogen peroxide catabolic process [GO:0042744]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979] | cell surface [GO:0009986]; cytosol [GO:0005829]; nucleus [GO:0005634] | thioredoxin peroxidase activity [GO:0008379] | PF10417;PF00578; | 3.40.30.10; | Peroxiredoxin family, AhpC/Prx1 subfamily | null | SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:16102003}. Nucleus {ECO:0000269|PubMed:16134099}. Cytoplasm {ECO:0000269|PubMed:16134099}. Note=Localizes to the cell surface in hyphally grown cells, whereas no surface but mainly nuclear localization is found in yeast-form cells. {ECO:0000269|PubMed:16102003}. | CATALYTIC ACTIVITY: Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence={ECO:0000250|UniProtK... | null | null | null | null | FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the corre... | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
P0CW18 | PRS56_HUMAN | MLLAVLLLLPLPSSWFAHGHPLYTRLPPSALQVLSAQGTQALQAAQRSAQWAINRVAMEIQHRSHECRGSGRPRPQALLQDPPEPGPCGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCFVGAPNELLWTVTLAEGSRGEQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPVSPGGSARPVCLPQEPQEPPAGTACAIAGWGALFEDGPEAEAVREARVPLLSTDTCRRALGPGLRPSTMLCAGYLAGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPG... | 3.4.21.- | null | blood coagulation [GO:0007596]; camera-type eye development [GO:0043010]; positive regulation of leukocyte chemotaxis [GO:0002690]; proteolysis [GO:0006508] | endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] | serine-type endopeptidase activity [GO:0004252] | PF00089; | 2.40.10.10; | Peptidase S1 family | null | null | null | null | null | null | null | FUNCTION: Serine protease required during eye development. {ECO:0000269|PubMed:21397065}. | Homo sapiens (Human) |
P0CW70 | D19L2_MOUSE | MVGPTRSKLREGSSDRPQSSCTGQARRRWSAATMEPQQERSAPQERTKWSLLQHFLLGGRKLPSGARNYAARRIQSLNAQNYFQLEEVAKLLLLNRFQFLFTLLDHFREKVQALQMHRFSHRTLFGLAIFVGILHWLHLITLFENDHHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLVINTVKRFHLYPEVVIAYWYRTIIGIMNLFGIETKTCWNVTRMEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFFIYSTYLSGSQLGGLITVACYFFNHGEATRVMWTPPLRESFSYPF... | 2.4.1.- | null | spermatid development [GO:0007286] | nuclear inner membrane [GO:0005637] | mannosyltransferase activity [GO:0000030] | PF10034; | null | Dpy-19 family | null | SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:22764053, ECO:0000269|PubMed:34471926}; Multi-pass membrane protein {ECO:0000305}. Note=Restricted to the inner nuclear membrane facing the acrosomal vesicle. The N- and C-termini are oriented towards the nucleoplasm (PubMed:22764053). Colocalizes with FA... | null | null | null | null | null | FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250|UniProtKB:P34413}.; FUNCTION: Required during spermatogenesis for sperm head elongation and acrosome formation. Also plays a role in acrosome attachment to the nuclear envelope. {ECO:0000269|Pu... | Mus musculus (Mouse) |
P0CW78 | HMA3B_ARATH | MAEGEESKKMNLQTSYFDVVGICCSSEVSIVGNVLRQVDGVKEFSVIVPSRTVIVVHDTFLISPLQIVKALNQARLEASVRPYGETSLKSQWPSPFAIVSGVLLVLSFFKYFYSPLEWLAIVAVVAGVFPILAKAVASVTRFRLDINALTLIAVIATLCMQDFTEAATIVFLFSVADWLESSAAHKASIVMSSLMSLAPRKAVIADTGLEVDVDEVGINTVVSVKAGESIPIDGVVVDGSCDVDEKTLTGESFPVSKQRESTVMAATINLNGYIKVKTTALARDCVVAKMTKLVEEAQKSQTKTQRFIDKCSRYYTPAVV... | 7.2.2.12; 7.2.2.21 | null | detoxification of cadmium ion [GO:0071585] | vacuolar membrane [GO:0005774] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type cadmium transporter activity [GO:0008551]; P-type zinc transporter activity [GO:0016463] | PF00122;PF00702; | 3.30.70.100;3.40.1110.10;2.70.150.10;3.40.50.1000; | Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily | null | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:15013746}; Multi-pass membrane protein {ECO:0000269|PubMed:15013746}. Note=Tonoplast. | CATALYTIC ACTIVITY: Reaction=ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out); Xref=Rhea:RHEA:20621, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.12; CATALYTIC ACTIVITY: Reaction=ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+)... | null | null | null | null | FUNCTION: In a heterologous system, involved in cadmium and lead transport, but not in zinc transport. May have a detoxification function through a vacuolar sequestration. {ECO:0000269|PubMed:15013746}. | Arabidopsis thaliana (Mouse-ear cress) |
P0CW86 | SODC1_SALTY | MKYTILSLVAGALISCSAMAENTLTVKMNDALSSGTGENIGEITVSETPYGLLFTPHLNGLTPGIHGFHVHTNPSCMPGMKDGKEVPALMAGGHLDPEKTGKHLGPYNDKGHLGDLPGLVVNADGTATYPLLAPRLKSLSELKGHSLMIHKGGDNYSDKPAPLGGGGARFACGVIEK | 1.15.1.1 | COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; Note=Binds 1 copper ion per subunit.; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; | removal of superoxide radicals [GO:0019430] | extracellular space [GO:0005615]; periplasmic space [GO:0042597] | copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; superoxide dismutase activity [GO:0004784] | PF00080; | 2.60.40.200; | Cu-Zn superoxide dismutase family | null | SUBCELLULAR LOCATION: Periplasm. | CATALYTIC ACTIVITY: Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; | null | null | null | null | FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
P0CW87 | ACSA1_KOMXY | MPEVRSSTQSESGMSQWMGKILSIRGAGLTIGVFGLCALIAATSVTLPPEQQLIVAFVCVVIFFIVGHKPSRRSQIFLEVLSGLVSLRYLTWRLTETLSFDTWLQGLLGTMLLVAELYALMMLFLSYFQTIAPLHRAPLPLPPNPDEWPTVDIFVPTYNEELSIVRLTVLGSLGIDWPPEKVRVHILDDGRRPEFAAFAAECGANYIARPTNEHAKAGNLNYAIGHTDGDYILIFDCDHVPTRAFLQLTMGWMVEDPKIALMQTPHHFYSPDPFQRNLSAGYRTPPEGNLFYGVVQDGNDFWDATFFCGSCAILRRTAIE... | 2.4.1.12 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; | cellulose biosynthetic process [GO:0030244]; UDP-glucose metabolic process [GO:0006011] | plasma membrane [GO:0005886] | cellulose synthase (UDP-forming) activity [GO:0016760]; cyclic-di-GMP binding [GO:0035438] | PF03170;PF00535;PF07238; | 2.60.120.260;2.40.10.220; | Glycosyltransferase 2 family; AcsB/BcsB family | null | SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:19929, Rhea:RHEA-COMP:10033, Rhea:RHEA-COMP:10034, ChEBI:CHEBI:15378, ChEBI:CHEBI:18246, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.12; | null | PATHWAY: Glycan metabolism; bacterial cellulose biosynthesis. | null | null | FUNCTION: Bifunctional protein comprised of a catalytic subunit and a regulatory subunit. The catalytic subunit of cellulose synthase polymerizes uridine 5'-diphosphate glucose to cellulose in a processive way. The thick cellulosic mats generated by this enzyme probably provide a specialized protective environment to t... | Komagataeibacter xylinus (Gluconacetobacter xylinus) |
P0CX25 | RL43A_YEAST | MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGKKTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | large ribosomal subunit rRNA binding [GO:0070180]; metal ion binding [GO:0046872]; structural constituent of ribosome [GO:0003735] | PF01780; | 2.20.25.30; | Eukaryotic ribosomal protein eL43 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX26 | RL43B_YEAST | MAKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSFCGKKTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | large ribosomal subunit rRNA binding [GO:0070180]; metal ion binding [GO:0046872]; structural constituent of ribosome [GO:0003735] | PF01780; | 2.20.25.30; | Eukaryotic ribosomal protein eL43 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX27 | RL44A_YEAST | MVNVPKTRKTYCKGKTCRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECVKCKTRAQLTLKRCKHFELGGEKKQKGQALQF | null | null | cytoplasmic translation [GO:0002181]; response to antibiotic [GO:0046677]; response to cycloheximide [GO:0046898] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | structural constituent of ribosome [GO:0003735] | PF00935; | 3.10.450.80; | Eukaryotic ribosomal protein eL42 family | PTM: In wild-type cells, 78% of L42 is monomethylated at both Lys-40 and Lys-55, and 22% are a mixture of species with either residue monomethylated. {ECO:0000269|PubMed:24517342}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX28 | RL44B_YEAST | MVNVPKTRKTYCKGKTCRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECVKCKTRAQLTLKRCKHFELGGEKKQKGQALQF | null | null | cytoplasmic translation [GO:0002181]; response to antibiotic [GO:0046677]; response to cycloheximide [GO:0046898] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | structural constituent of ribosome [GO:0003735] | PF00935; | 3.10.450.80; | Eukaryotic ribosomal protein eL42 family | PTM: In wild-type cells, 78% of L42 is monomethylated at both Lys-40 and Lys-55, and 22% are a mixture of species with either residue monomethylated. {ECO:0000269|PubMed:24517342}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX29 | RS23A_YEAST | MGKGKPRGLNSARKLRVHRRNNRWAENNYKKRLLGTAFKSSPFGGSSHAKGIVLEKLGIESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS | null | null | maintenance of translational fidelity [GO:1990145]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of translational fidelity [GO:0006450]; translation [GO:0006412] | cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; ribosome [GO:0005840] | structural constituent of ribosome [GO:0003735] | PF00164; | 2.40.50.140; | Universal ribosomal protein uS12 family | PTM: Hydroxylation at Pro-64 affects translation termination efficiency. The stereochemistry of the 3,4-dihydroxyproline has not yet been determined. {ECO:0000269|PubMed:24550462}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX30 | RS23B_YEAST | MGKGKPRGLNSARKLRVHRRNNRWAENNYKKRLLGTAFKSSPFGGSSHAKGIVLEKLGIESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS | null | null | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of translational fidelity [GO:0006450]; translation [GO:0006412] | cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; ribosome [GO:0005840] | structural constituent of ribosome [GO:0003735] | PF00164; | 2.40.50.140; | Universal ribosomal protein uS12 family | PTM: Hydroxylation at Pro-64 affects translation termination efficiency. The stereochemistry of the 3,4-dihydroxyproline has not yet been determined. {ECO:0000269|PubMed:24550462}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX31 | RS24A_YEAST | MSDAVTIRTRKVISNPLLARKQFVVDVLHPNRANVSKDELREKLAEVYKAEKDAVSVFGFRTQFGGGKSVGFGLVYNSVAEAKKFEPTYRLVRYGLAEKVEKASRQQRKQKKNRDKKIFGTGKRLAKKVARRNAD | null | null | cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462] | cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; mitochondrion [GO:0005739] | structural constituent of ribosome [GO:0003735] | PF01282; | 3.30.70.3370; | Eukaryotic ribosomal protein eS24 family | PTM: N-terminally acetylated by acetyltransferase NatA. Also partially acetylated by NatC. {ECO:0000269|PubMed:10601260, ECO:0000269|PubMed:1544921}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX32 | RS24B_YEAST | MSDAVTIRTRKVISNPLLARKQFVVDVLHPNRANVSKDELREKLAEVYKAEKDAVSVFGFRTQFGGGKSVGFGLVYNSVAEAKKFEPTYRLVRYGLAEKVEKASRQQRKQKKNRDKKIFGTGKRLAKKVARRNAD | null | null | cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462] | cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] | structural constituent of ribosome [GO:0003735] | PF01282; | 3.30.70.3370; | Eukaryotic ribosomal protein eS24 family | PTM: N-terminally acetylated by acetyltransferase NatA. Also partially acetylated by NatC. {ECO:0000269|PubMed:1544921}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX35 | RS4A_YEAST | MARGPKKHLKRLAAPHHWLLDKLSGCYAPRPSAGPHKLRESLPLIVFLRNRLKYALNGREVKAILMQRHVKVDGKVRTDTTYPAGFMDVITLDATNENFRLVYDVKGRFAVHRITDEEASYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPNIKVNDTVKIDLASGKITDFIKFDAGKLVYVTGGRNLGRIGTIVHKERHDGGFDLVHIKDSLDNTFVTRLNNVFVIGEQGKPYISLPKGKGIKLSIAEERDRRRAQQGL | null | null | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] | RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | PF16121;PF00467;PF00900;PF08071;PF01479; | 2.30.30.30;2.40.50.740;3.10.290.10; | Eukaryotic ribosomal protein eS4 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX36 | RS4B_YEAST | MARGPKKHLKRLAAPHHWLLDKLSGCYAPRPSAGPHKLRESLPLIVFLRNRLKYALNGREVKAILMQRHVKVDGKVRTDTTYPAGFMDVITLDATNENFRLVYDVKGRFAVHRITDEEASYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPNIKVNDTVKIDLASGKITDFIKFDAGKLVYVTGGRNLGRIGTIVHKERHDGGFDLVHIKDSLDNTFVTRLNNVFVIGEQGKPYISLPKGKGIKLSIAEERDRRRAQQGL | null | null | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] | RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | PF16121;PF00467;PF00900;PF08071;PF01479; | 2.30.30.30;2.40.50.740;3.10.290.10; | Eukaryotic ribosomal protein eS4 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX37 | RS6A_YEAST | MKLNISYPVNGSQKTFEIDDEHRIRVFFDKRIGQEVDGEAVGDEFKGYVFKISGGNDKQGFPMKQGVLLPTRIKLLLTKNVSCYRPRRDGERKRKSVRGAIVGPDLAVLALVIVKKGEQELEGLTDTTVPKRLGPKRANNIRKFFGLSKEDDVRDFVIRREVTKGEKTYTKAPKIQRLVTPQRLQRKRHQRALKVRNAQAQREAAAEYAQLLAKRLSERKAEKAEIRKRRASSLKA | null | null | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] | structural constituent of ribosome [GO:0003735] | PF01092; | 1.20.5.2650; | Eukaryotic ribosomal protein eS6 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22096102}. Nucleus, nucleolus {ECO:0000269|PubMed:15590835}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX38 | RS6B_YEAST | MKLNISYPVNGSQKTFEIDDEHRIRVFFDKRIGQEVDGEAVGDEFKGYVFKISGGNDKQGFPMKQGVLLPTRIKLLLTKNVSCYRPRRDGERKRKSVRGAIVGPDLAVLALVIVKKGEQELEGLTDTTVPKRLGPKRANNIRKFFGLSKEDDVRDFVIRREVTKGEKTYTKAPKIQRLVTPQRLQRKRHQRALKVRNAQAQREAAAEYAQLLAKRLSERKAEKAEIRKRRASSLKA | null | null | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] | structural constituent of ribosome [GO:0003735] | PF01092; | 1.20.5.2650; | Eukaryotic ribosomal protein eS6 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22096102}. Nucleus, nucleolus {ECO:0000269|PubMed:15590835}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX39 | RS8A_YEAST | MGISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGAKRIHSVRTRGGNKKYRALRIETGNFSWASEGISKKTRIAGVVYHPSNNELVRTNTLTKAAIVQIDATPFRQWFEAHYGQTLGKKKNVKEEETVAKSKNAERKWAARAASAKIESSVESQFSAGRLYACISSRPGQSGRCDGYILEGEELAFYLRRLTAKK | null | null | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] | structural constituent of ribosome [GO:0003735] | PF01201; | 3.10.290.70;1.10.168.20; | Eukaryotic ribosomal protein eS8 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX40 | RS8B_YEAST | MGISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGAKRIHSVRTRGGNKKYRALRIETGNFSWASEGISKKTRIAGVVYHPSNNELVRTNTLTKAAIVQIDATPFRQWFEAHYGQTLGKKKNVKEEETVAKSKNAERKWAARAASAKIESSVESQFSAGRLYACISSRPGQSGRCDGYILEGEELAFYLRRLTAKK | null | null | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] | structural constituent of ribosome [GO:0003735] | PF01201; | 3.10.290.70;1.10.168.20; | Eukaryotic ribosomal protein eS8 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX41 | RL23A_YEAST | MSGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSRLNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIANPKGEMKGSAITGPVGKECADLWPRVASNSGVVV | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] | PF00238; | 2.40.150.20; | Universal ribosomal protein uL14 family | PTM: Methylated by RKM1 at 2 different sites, but it is unclear which are the 2 methylated residues among Lys-40, Lys-106 and/or Lys-110. {ECO:0000269|PubMed:16096273}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX42 | RL23B_YEAST | MSGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSRLNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIANPKGEMKGSAITGPVGKECADLWPRVASNSGVVV | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; nucleus [GO:0005634] | large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] | PF00238; | 2.40.150.20; | Universal ribosomal protein uL14 family | PTM: Methylated by RKM1 at 2 different sites, but it is unclear which are the 2 methylated residues among Lys-40, Lys-106 and/or Lys-110. {ECO:0000269|PubMed:16096273}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX43 | RL1A_YEAST | MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQRDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKKLSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLKKVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY | null | null | cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; ribosomal large subunit export from nucleus [GO:0000055] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | PF00687; | 3.30.190.20;3.40.50.790; | Universal ribosomal protein uL1 family | PTM: N-terminally acetylated by acetyltransferase NatA. {ECO:0000269|PubMed:10601260}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX44 | RL1B_YEAST | MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQRDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKKLSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLKKVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY | null | null | cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; ribosomal large subunit export from nucleus [GO:0000055] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | PF00687; | 3.30.190.20;3.40.50.790; | Universal ribosomal protein uL1 family | PTM: N-terminally acetylated by acetyltransferase NatA. {ECO:0000269|PubMed:10601260}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX45 | RL2A_YEAST | MGRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHDSGRGAPLAKVVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKPGDRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISSDARGVIGVIAGGGRVDKPLLKAGRAFHKYRLKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAARRTGLLRGSQKTQD | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | PF00181;PF03947; | 2.30.30.30;2.40.50.140;4.10.950.10; | Universal ribosomal protein uL2 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX46 | RL2B_YEAST | MGRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHDSGRGAPLAKVVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKPGDRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISSDARGVIGVIAGGGRVDKPLLKAGRAFHKYRLKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAARRTGLLRGSQKTQD | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | PF00181;PF03947; | 2.30.30.30;2.40.50.140;4.10.950.10; | Universal ribosomal protein uL2 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX47 | RS11A_YEAST | MSTELTVQSERAFQKQPHIFNNPKVKTSKRTKRWYKNAGLGFKTPKTAIEGSYIDKKCPFTGLVSIRGKILTGTVVSTKMHRTIVIRRAYLHYIPKYNRYEKRHKNVPVHVSPAFRVQVGDIVTVGQCRPISKTVRFNVVKVSAAAGKANKQFAKF | null | null | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] | rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | PF00366;PF16205; | 2.40.50.1000; | Universal ribosomal protein uS17 family | PTM: N-terminally acetylated by acetyltransferase NatA. {ECO:0000269|PubMed:10601260, ECO:0000269|PubMed:1544921}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX48 | RS11B_YEAST | MSTELTVQSERAFQKQPHIFNNPKVKTSKRTKRWYKNAGLGFKTPKTAIEGSYIDKKCPFTGLVSIRGKILTGTVVSTKMHRTIVIRRAYLHYIPKYNRYEKRHKNVPVHVSPAFRVQVGDIVTVGQCRPISKTVRFNVVKVSAAAGKANKQFAKF | null | null | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] | rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | PF00366;PF16205; | 2.40.50.1000; | Universal ribosomal protein uS17 family | PTM: N-terminally acetylated by acetyltransferase NatA. {ECO:0000269|PubMed:1544921}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX49 | RL18A_YEAST | MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | PF17135; | 3.100.10.10; | Eukaryotic ribosomal protein eL18 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX50 | RL18B_YEAST | MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | PF17135; | 3.100.10.10; | Eukaryotic ribosomal protein eL18 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX51 | RS16A_YEAST | MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR | null | null | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | PF00380; | 3.30.230.10; | Universal ribosomal protein uS9 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX53 | RL12A_YEAST | MPPKFDPNEVKYLYLRAVGGEVGASAALAPKIGPLGLSPKKVGEDIAKATKEFKGIKVTVQLKIQNRQAAASVVPSASSLVITALKEPPRDRKKDKNVKHSGNIQLDEIIEIARQMRDKSFGRTLASVTKEILGTAQSVGCRVDFKNPHDIIEGINAGEIEIPEN | null | null | cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] | PF00298;PF03946; | 1.10.10.250;3.30.1550.10; | Universal ribosomal protein uL11 family | PTM: It appears that the main modified species for L12 contains 6 methyl groups, 2 on Pro-2, 3 on Lys-4 and 1 on Arg-67. Although not reproduced with a second method, methylation at Lys-11 cannot be ruled out. {ECO:0000269|PubMed:11856739, ECO:0000269|PubMed:17005568, ECO:0000269|PubMed:18957409, ECO:0000269|PubMed:204... | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX54 | RL12B_YEAST | MPPKFDPNEVKYLYLRAVGGEVGASAALAPKIGPLGLSPKKVGEDIAKATKEFKGIKVTVQLKIQNRQAAASVVPSASSLVITALKEPPRDRKKDKNVKHSGNIQLDEIIEIARQMRDKSFGRTLASVTKEILGTAQSVGCRVDFKNPHDIIEGINAGEIEIPEN | null | null | cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] | PF00298;PF03946; | 1.10.10.250;3.30.1550.10; | Universal ribosomal protein uL11 family | PTM: It appears that the main modified species for L12 contains 6 methyl groups, 2 on Pro-2, 3 on Lys-4 and 1 on Arg-67. Although not reproduced with a second method, methylation at Lys-11 cannot be ruled out. {ECO:0000269|PubMed:11856739, ECO:0000269|PubMed:17005568, ECO:0000269|PubMed:18957409, ECO:0000269|PubMed:204... | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX55 | RS18A_YEAST | MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQHTKTTGRRRA | null | null | cytoplasmic translation [GO:0002181]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; ribosomal subunit export from nucleus [GO:0000054] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; mitochondrion [GO:0005739]; small ribosomal subunit [GO:0015935] | rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | PF00416; | 1.10.8.50;4.10.910.10; | Universal ribosomal protein uS13 family | PTM: N-terminally acetylated by acetyltransferase NatA. {ECO:0000269|PubMed:10601260, ECO:0000269|Ref.3}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX56 | RS18B_YEAST | MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQHTKTTGRRRA | null | null | cytoplasmic translation [GO:0002181]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; ribosomal subunit export from nucleus [GO:0000054] | cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; mitochondrion [GO:0005739]; small ribosomal subunit [GO:0015935] | rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | PF00416; | 1.10.8.50;4.10.910.10; | Universal ribosomal protein uS13 family | PTM: N-terminally acetylated by acetyltransferase NatA. {ECO:0000269|PubMed:10601260, ECO:0000269|Ref.3}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX63 | YF21B_YEAST | MESQQLHQNPHSLHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAETKVRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKSQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYL... | 2.7.7.49; 2.7.7.7; 3.1.26.4; 3.4.23.- | null | DNA integration [GO:0015074]; DNA recombination [GO:0006310]; proteolysis [GO:0006508]; retrotransposition [GO:0032197] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; retrotransposon nucleocapsid [GO:0000943] | aspartic-type endopeptidase activity [GO:0004190]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; RNA-directed DNA polymerase activity [G... | PF00665;PF07727;PF01021; | 3.30.420.10; | null | PTM: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the part... | SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.49; CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)... | null | null | null | null | FUNCTION: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX64 | YG22B_YEAST | MESQQLHQNPHSLHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAETKVRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKSQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYL... | 2.7.7.49; 2.7.7.7; 3.1.26.4; 3.4.23.- | null | DNA integration [GO:0015074]; DNA recombination [GO:0006310]; proteolysis [GO:0006508]; retrotransposition [GO:0032197] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; retrotransposon nucleocapsid [GO:0000943] | aspartic-type endopeptidase activity [GO:0004190]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; RNA-directed DNA polymerase activity [G... | PF00665;PF07727;PF01021; | 3.30.420.10; | null | PTM: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the part... | SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.49; CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)... | null | null | null | null | FUNCTION: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX77 | ASP22_YEAST | MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDA... | 3.5.1.1 | null | asparagine catabolic process [GO:0006530]; cellular response to nitrogen starvation [GO:0006995] | cell wall-bounded periplasmic space [GO:0030287]; cytosol [GO:0005829]; extracellular region [GO:0005576]; periplasmic space [GO:0042597] | asparaginase activity [GO:0004067] | PF00710;PF17763; | 3.40.50.40;3.40.50.1170; | Asparaginase 1 family | null | SUBCELLULAR LOCATION: Secreted. Periplasm. | CATALYTIC ACTIVITY: Reaction=H2O + L-asparagine = L-aspartate + NH4(+); Xref=Rhea:RHEA:21016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:58048; EC=3.5.1.1; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.27 mM for L-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0.27 mM for D-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0.27 mM for N-acetyl-L-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0... | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.8. Active from pH 5.5 to pH 7.5. Stable from pH 3.5 to pH 10.5. {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; | null | null | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX78 | ASP23_YEAST | MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDA... | 3.5.1.1 | null | asparagine catabolic process [GO:0006530]; cellular response to nitrogen starvation [GO:0006995] | cell wall-bounded periplasmic space [GO:0030287]; cytosol [GO:0005829]; extracellular region [GO:0005576]; periplasmic space [GO:0042597] | asparaginase activity [GO:0004067] | PF00710;PF17763; | 3.40.50.40;3.40.50.1170; | Asparaginase 1 family | null | SUBCELLULAR LOCATION: Secreted. Periplasm. | CATALYTIC ACTIVITY: Reaction=H2O + L-asparagine = L-aspartate + NH4(+); Xref=Rhea:RHEA:21016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:58048; EC=3.5.1.1; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.27 mM for L-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0.27 mM for D-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0.27 mM for N-acetyl-L-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0... | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.8. Active from pH 5.5 to pH 7.5. Stable from pH 3.5 to pH 10.5. {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; | null | null | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX79 | ASP24_YEAST | MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDA... | 3.5.1.1 | null | asparagine catabolic process [GO:0006530]; cellular response to nitrogen starvation [GO:0006995] | cell periphery [GO:0071944]; cell wall-bounded periplasmic space [GO:0030287]; cytosol [GO:0005829]; extracellular region [GO:0005576]; periplasmic space [GO:0042597] | asparaginase activity [GO:0004067] | PF00710;PF17763; | 3.40.50.40;3.40.50.1170; | Asparaginase 1 family | null | SUBCELLULAR LOCATION: Secreted. Periplasm. | CATALYTIC ACTIVITY: Reaction=H2O + L-asparagine = L-aspartate + NH4(+); Xref=Rhea:RHEA:21016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:58048; EC=3.5.1.1; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.27 mM for L-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0.27 mM for D-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0.27 mM for N-acetyl-L-asparagine {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; KM=0... | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.8. Active from pH 5.5 to pH 7.5. Stable from pH 3.5 to pH 10.5. {ECO:0000269|PubMed:342521, ECO:0000269|PubMed:6986375}; | null | null | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX80 | MTCU1_YEAST | MFSELINFQNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGNKSEETKKSCCSGK | null | null | detoxification of cadmium ion [GO:0071585]; detoxification of copper ion [GO:0010273]; removal of superoxide radicals [GO:0019430]; response to copper ion [GO:0046688] | cytosol [GO:0005829] | antioxidant activity [GO:0016209]; cadmium ion binding [GO:0046870]; copper ion binding [GO:0005507]; superoxide dismutase activity [GO:0004784] | PF11403; | 4.10.650.10; | Metallothionein superfamily, Type 12 family | null | null | null | null | null | null | null | FUNCTION: Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins. | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX81 | MTCU2_YEAST | MFSELINFQNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGNKSEETKKSCCSGK | null | null | detoxification of cadmium ion [GO:0071585]; detoxification of copper ion [GO:0010273]; removal of superoxide radicals [GO:0019430]; response to copper ion [GO:0046688] | cytosol [GO:0005829] | antioxidant activity [GO:0016209]; cadmium ion binding [GO:0046870]; copper ion binding [GO:0005507]; superoxide dismutase activity [GO:0004784] | PF11403; | 4.10.650.10; | Metallothionein superfamily, Type 12 family | null | null | null | null | null | null | null | FUNCTION: Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins. | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX82 | RL19A_YEAST | MANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAIRKLVKNGTIVKKAVTVHSKSRTRAHAQSKREGRHSGYGKRKGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLYHVLYKESKGNAFKHKRALVEHIIQAKADAQREKALNEEAEARRLKNRAARDRRAQRVAEKRDALLKEDA | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | PF01280; | 1.10.1200.240;1.10.1650.10; | Eukaryotic ribosomal protein eL19 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX83 | RL19B_YEAST | MANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAIRKLVKNGTIVKKAVTVHSKSRTRAHAQSKREGRHSGYGKRKGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLYHVLYKESKGNAFKHKRALVEHIIQAKADAQREKALNEEAEARRLKNRAARDRRAQRVAEKRDALLKEDA | null | null | cytoplasmic translation [GO:0002181] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | PF01280; | 1.10.1200.240;1.10.1650.10; | Eukaryotic ribosomal protein eL19 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX84 | RL35A_YEAST | MAGVKAYELRTKSKEQLASQLVDLKKELAELKVQKLSRPSLPKIKTVRKSIACVLTVINEQQREAVRQLYKGKKYQPKDLRAKKTRALRRALTKFEASQVTEKQRKKQIAFPQRKYAIKA | null | null | cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; preribosome, large subunit precursor [GO:0030687] | mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735] | PF00831; | 1.10.287.310;6.10.250.3450; | Universal ribosomal protein uL29 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CX85 | RL35B_YEAST | MAGVKAYELRTKSKEQLASQLVDLKKELAELKVQKLSRPSLPKIKTVRKSIACVLTVINEQQREAVRQLYKGKKYQPKDLRAKKTRALRRALTKFEASQVTEKQRKKQIAFPQRKYAIKA | null | null | cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; preribosome, large subunit precursor [GO:0030687] | mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735] | PF00831; | 1.10.287.310;6.10.250.3450; | Universal ribosomal protein uL29 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}. | null | null | null | null | null | FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains t... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CY06 | MTAL1_YEAST | MFTSKPAFKIKNKASKSYRNTAVSKKLKEKRLAEHVRPSCFNIIRPLKKDIQIPVPSSRFLNKIQIHRIASGSQNTQFRQFNKTSIKSSKKYLNSFMAFRAYYSQFGSGVKQNVLSSLLAEEWHADKMQHGIWDYFAQQYNFINPGFGFVEWLTNNYAEVRGDGYWEDVFVHLAL | null | null | positive regulation of mating-type specific transcription, DNA-templated [GO:0045895]; regulation of mating-type specific transcription, DNA-templated [GO:0007532]; regulation of transcription by RNA polymerase II [GO:0006357] | nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] | DNA binding, bending [GO:0008301]; transcription coactivator activity [GO:0003713] | PF04769; | null | MATALPHA1 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00655}. | null | null | null | null | null | FUNCTION: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional coactivator that, in alpha-cells, binds cooperatively with MCM1 and STE12 to a DNA sequence termed the QP' elemen... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CY08 | MTAL2_YEAST | MNKIPIKDLLNPQITDEFKSSILDINKKLFSICCNLPKLPESVTTEEEVELRDILGFLSRANKNRKISDEEKKLLQTTSQLTTTITVLLKEMRSIENDRSNYQLTQKNKSADGLVFNVVTQDMINKSTKPYRGHRFTKENVRILESWFAKNIENPYLDTKGLENLMKNTSLSRIQIKNWVSNRRRKEKTITIAPELADLLSGEPLAKKKE | null | null | negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of mating-type specific transcription, DNA-templated [GO:0007532]; regulation of transcription by RNA polymerase II [GO:0006357] | nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571] | DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding ... | PF00046; | 1.10.10.60; | TALE/M-ATYP homeobox family | null | SUBCELLULAR LOCATION: Nucleus. | null | null | null | null | null | FUNCTION: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that binds cooperatively with MCM1 to a 31-basepair DNA sequence termed the a-specific gene (asg) ope... | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
P0CY17 | MATMC_SCHPO | MDSHQELSAGSPISYDFLDPDWCFKRYLTKDALHSIETGKGAAYFVPDGFTPILIPNSQSYLLDGNSAQLPRPQPISFTLDQCKVPGYILKSLRKDTTSTERTPRPPNAFILYRKEKHATLLKSNPSINNSQVSKLVGEMWRNESKEVRMRYFKMSEFYKAQHQKMYPGYKYQPRKNKVKR | null | null | anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; induction of conjugation with cellular fusion [GO:0010514]; mating type determination [GO:0007531]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of induction of conjugation with cellular fu... | cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; spindle pole body [GO:0005816] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending [GO:0044377]; sequence-specific DNA binding, bending [GO:0044374]; tra... | PF00505; | 1.10.30.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}. | null | null | null | null | null | FUNCTION: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Positive regulator of MFM genes. The HMG box recognizes the DNA sequence 5'-AACAAAG-3'. Required for conjugation and efficient me... | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
P0CY24 | STE20_CANAL | MSILSENNPTQTSITDPNESSHLHNPELNSGTRVASGPGPGPEVESTPLAPPTEVMNTTSANTSSLSLGSPMHEKIKQFDQDEVDTGETNDRTIESGSSDIDDSQQSHNNNNNNNNNESNPESSEADDEKTQGMPPRMPGTFNVKGLHQGDDSDNEKQYTELTKSINKRTSKDSYSPGTLESPGTLNALETNNVSPAVIEEEQHTSSLEDLSLSLQHQNENARLSAPRSAPPQVSTSKTSSFHDMSSVISSSTSVHKIPSNPTSTRGSHLSSYKSTLDPGKPAQAAAPPPPEIDIDNLLTKSELDSETDTLSSATNSPNL... | 2.7.11.1 | null | cellular response to starvation [GO:0009267]; chlamydospore formation [GO:0001410]; filamentous growth [GO:0030447]; filamentous growth of a population of unicellular organisms [GO:0044182]; filamentous growth of a population of unicellular organisms in response to starvation [GO:0036170]; fungal-type cell wall organiz... | cytoplasm [GO:0005737]; nucleus [GO:0005634] | ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00786;PF00069; | 3.90.810.10;1.10.510.10; | Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[pr... | null | null | null | null | FUNCTION: MAP4K component of the MAPK pathway required for the mating pheromone response, and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Required for hyphal formation and virulence. {ECO:0000250, ECO:0000269|PubMed:12453219}. | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
P0CY26 | CARP1_CANAX | MFLKNIFIALAIALLVDASPAKRSPGFVTLDFDVIKTPVNATGQEGKVKRQAIPVTLNNELVSYAADITIGSNKQKFNVIVDTGSSDLWVPDASVTCDKPRPGQSADFCKGKGIYTPKSSTTSQNLGSPFYIGYGDGSSSQGTLYKDTVGFGGASITKQVFADITKTSIPQGILGIGYKTNEAAGDYDNVPVTLKNQGVIAKNAYSLYLNSPNAATGQIIFGGVDKAKYSGSLIAVPVTSDRELRITLNSLKAVGKNINGNIDVLLDSGTTITYLQQDVAQDIIDAFQAELKSDGQGHTFYVTDCQTSGTVDFNFDNNAK... | 3.4.23.24 | null | proteolysis [GO:0006508] | extracellular region [GO:0005576] | aspartic-type endopeptidase activity [GO:0004190]; metal ion binding [GO:0046872] | PF00026; | 2.40.70.10; | Peptidase A1 family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11065355, ECO:0000269|PubMed:8478090, ECO:0000269|PubMed:9841840}. | CATALYTIC ACTIVITY: Reaction=Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.; EC=3.4.23.24; Evidence={ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:... | null | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 5.0. using BSA or casein-resorufin as substrates, and 6.0-7.0, the pH of the saliva, for cleavage of Hst 5. {ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:0000269|PubMed:9043112}; | null | FUNCTION: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:10569787, PubMed:11478679, PubMed:12761103, PubMed:1447155, PubMed:15845479, PubMed:19880183, PubMed:20713630, PubMed:22302440, PubMed:23927842). These enzymes supply the fungus with nutrient a... | Candida albicans (Yeast) |
P0CY27 | CARP1_CANAL | MFLKNIFIALAIALLVDASPAKRSPGFVTLDFDVIKTPVNATGQEGKVKRQAIPVTLNNEHVSYAADITIGSNKQKFNVIVDTGSSDLWVPDASVTCDKPRPGQSADFCKGKGIYTPKSSTTSQNLGTPFYIGYGDGSSSQGTLYKDTVGFGGASITKQVFADITKTSIPQGILGIGYKTNEAAGDYDNVPVTLKNQGVIAKNAYSLYLNSPNAATGQIIFGGVDKAKYSGSLIAVPVTSDRELRITLNSLKAVGKNINGNIDVLLDSGTTITYLQQDVAQDIIDAFQAELKSDGQGHTFYVTDCQTSGTVDFNFDNNAK... | 3.4.23.24 | null | adhesion of symbiont to host [GO:0044406]; fungal-type cell wall organization [GO:0031505]; induction by symbiont of defense-related host calcium ion flux [GO:0052391]; induction by symbiont of host defense response [GO:0044416]; protein catabolic process [GO:0030163]; protein metabolic process [GO:0019538]; proteolysi... | extracellular region [GO:0005576]; fungal-type cell wall [GO:0009277] | aspartic-type endopeptidase activity [GO:0004190]; metal ion binding [GO:0046872] | PF00026; | 2.40.70.10; | Peptidase A1 family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11065355, ECO:0000269|PubMed:8478090, ECO:0000269|PubMed:9841840}. | CATALYTIC ACTIVITY: Reaction=Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.; EC=3.4.23.24; Evidence={ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:... | null | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 5.0. using BSA or casein-resorufin as substrates, and 6.0-7.0, the pH of the saliva, for cleavage of Hst 5. {ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:0000269|PubMed:9043112}; | null | FUNCTION: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:10569787, PubMed:11478679, PubMed:12761103, PubMed:1447155, PubMed:15845479, PubMed:19880183, PubMed:20713630, PubMed:22302440, PubMed:23927842). These enzymes supply the fungus with nutrient a... | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
P0CY28 | CARP3_CANAX | MFLKNIFIALAIALLADATPTTFNNSPGFVALNFDVIKTHKNVTGPQGEINTNVNVKRQTVPVKLINEQVSYASDITVGSNKQKLTVVIDTGSSDLWVPDSQVSCQAGQGQDPNFCKNEGTYSPSSSSSSQNLNSPFSIEYGDGTTSQGTWYKDTIGFGGISITKQQFADVTSTSVDQGILGIGYKTHEAEGNYDNVPVTLKNQGIISKNAYSLYLNSRQATSGQIIFGGVDNAKYSGTLIALPVTSDNELRIHLNTVKVAGQSINADVDVLLDSGTTITYLQQGVADQVISAFNGQETYDANGNLFYLVDCNLSGSVDF... | 3.4.23.24 | null | proteolysis [GO:0006508] | extracellular region [GO:0005576] | aspartic-type endopeptidase activity [GO:0004190]; metal ion binding [GO:0046872] | PF00026; | 2.40.70.10; | Peptidase A1 family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0CY27}. | CATALYTIC ACTIVITY: Reaction=Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.; EC=3.4.23.24; Evidence={ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:... | null | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 3.0 using BSA or casein-resorufin as substrates, and 6.0-7.0, the pH of the saliva, for cleavage of Hst 5. {ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:0000269|PubMed:9043112}; | null | FUNCTION: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:11478679, PubMed:19880183, PubMed:20713630, PubMed:23927842). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in t... | Candida albicans (Yeast) |
P0CY29 | CARP3_CANAL | MFLKNIFIALAIALLADATPTTFNNSPGFVALNFDVIKTHKNVTGPQGEINTNVNVKRQTVPVKLINEQVSYASDITVGSNKQKLTVVIDTGSSDLWVPDSQVSCQAGQGQDPNFCKNEGTYSPSSSSSSQNLNSPFSIEYGDGTTSQGTWYKDTIGFGGISITKQQFADVTSTSVDQGILGIGYKTHEAEGNYDNVPVTLKNQGIISKNAYSLYLNSRQATSGQIIFGGVDNAKYSGTLIALPVTSDNELRIHLNTVKVAGQSINADVDVLLDSGTTITYLQQGVADQVISAFNGQETYDANGNLFYLVDCNLSGSVDF... | 3.4.23.24 | null | adhesion of symbiont to host [GO:0044406]; fungal-type cell wall organization [GO:0031505]; induction by symbiont of defense-related host calcium ion flux [GO:0052391]; protein catabolic process [GO:0030163]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]; symbi... | extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; fungal-type cell wall [GO:0009277] | aspartic-type endopeptidase activity [GO:0004190] | PF00026; | 2.40.70.10; | Peptidase A1 family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0CY27}. | CATALYTIC ACTIVITY: Reaction=Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.; EC=3.4.23.24; Evidence={ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:... | null | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 3.0 using BSA or casein-resorufin as substrates, and 6.0-7.0, the pH of the saliva, for cleavage of Hst 5. {ECO:0000269|PubMed:21646240, ECO:0000269|PubMed:27390786, ECO:0000269|PubMed:9043112}; | null | FUNCTION: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:11478679, PubMed:19880183, PubMed:20713630, PubMed:23927842). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in t... | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
P0CY31 | SEC4_CANAL | MSGKGTSSRAYDMIMKLLLVGDSGVGKSCLLLRFVEDKFNPSFITTIGIDFKIRTIESKGKRIKLQVWDTAGQERFRTITTAYYRGAMGIVLIYDVTDSRSFENVENWFQTVTQHANEDAQIFLVGNKCDDEVNRQVSKEQGQELAAKLNVPFLEASAKSNENVDSIFYELASIIQEKHVEENIGGVGGASGAGGIDVSQNNSGAKNNCC | null | null | ascospore-type prospore assembly [GO:0031321]; autophagy [GO:0006914]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; Golgi vesicle fusion to target membrane [GO:0048210]; membrane addition at site of cytokinesis [GO:0007107]; protein localization to plasma m... | cellular bud tip [GO:0005934]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; incipient cellular bud site [GO:0000131]; mating projection tip [GO:0043332]; plasma membrane [GO:0005886]; spitzenkorper [GO:0031521]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle membrane [GO:0030658] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Rab family | null | SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. | null | null | null | null | null | FUNCTION: Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 ... | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
P0CY32 | RAS1_CANAX | MLREYKLVVVGGGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKQCTIDDQQVLLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSINSLNSFQELNSFYDQILRVKDSDNVPVLVVGNKCDLEMERQVSYEDGLALANSFNCPFLETSAKQRINVEEAFYGLVRNINQYNAKIAEAEKQQQQQQQQQNANQQGQDQYGQQKDNQQSQFNNQINNNNNTSAVNGGVSSDGIIDQNGNGGVSSGQANLPNQSQSQSQRQQQQQQQEPQQQSENQFSGQKQSSSKSKNGCCVIV | 3.6.5.2 | null | conjugation with cellular fusion [GO:0000747]; establishment of cell polarity [GO:0030010]; positive regulation of mating projection assembly [GO:1902917]; positive regulation of pheromone response MAPK cascade [GO:0062038]; positive regulation of protein import into nucleus [GO:0042307]; protein localization to plasma... | cell cortex of cell tip [GO:0051285]; cortical dynamic polarity patch [GO:0090726]; division septum [GO:0000935]; mating projection actin fusion focus [GO:1990819]; plasma membrane [GO:0005886] | CTP binding [GO:0002135]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; UTP binding [GO:0002134] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Ras family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01112}; | null | null | null | null | FUNCTION: Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity). {ECO:0000250}. | Candida albicans (Yeast) |
P0CY33 | CDC42_CANAL | MQTIKCVVVGDGAVGKTCLLISYTTSKFPADYVPTVFDNYAVTVMIGDEPFTLGLFDTAGQEDYDRLRPLSYPSTDVFLVCFSVISPASFENVKEKWFPEVHHHCPGVPIIIVGTQTDLRNDDVILQRLHRQKLSPITQEQGEKLAKELRAVKYVECSALTQRGLKTVFDEAIVAALEPPVIKKSKKCTIL | null | null | actin filament organization [GO:0007015]; budding cell apical bud growth [GO:0007118]; budding cell isotropic bud growth [GO:0007119]; Cdc42 protein signal transduction [GO:0032488]; cell budding [GO:0007114]; cell cycle [GO:0007049]; cell growth mode switching, budding to filamentous [GO:0036187]; cell morphogenesis [... | cell septum [GO:0030428]; cellular bud neck [GO:0005935]; cellular bud tip [GO:0005934]; extracellular vesicle [GO:1903561]; fungal-type vacuole membrane [GO:0000329]; hyphal tip [GO:0001411]; hyphal tip polarisome [GO:0031562]; incipient cellular bud site [GO:0000131]; mating projection tip [GO:0043332]; membrane [GO:... | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Rho family, CDC42 subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. | null | null | null | null | null | FUNCTION: Involved in hyphal formation, virulence, morphogenesis. | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
P0CY34 | TUP1_CANAL | MYPQRTQHQQRLTELLDAIKTEFDYASNEASSFKKVQEDYDSKYQQQAAEMQQIRQTVYDLELAHRKIKEAYEEEILRLKNELDTRDRQMKNGFQQQQQQQQQQQQQQQQQQQQIVAPPAAPPAPPTPVTSLSVIDKSQYIVNPTQRANHVKEIPPFLQDLDIAKANPEFKKQHLEYYVLYNPAFSKDLDIDMVHSLDHSSVVCCVRFSRDGKFIATGCNKTTQVFNVTTGELVAKLIDESSNENKDDNTTASGDLYIRSVCFSPDGKLLATGAEDKLIRIWDLSTKRIIKILRGHEQDIYSLDFFPDGDRLVSGSGDRS... | null | null | carbon catabolite repression of transcription from RNA polymerase II promoter by glucose [GO:0000433]; cell-cell adhesion [GO:0098609]; cellular response to copper ion [GO:0071280]; cellular response to farnesol [GO:0097308]; cellular response to starvation [GO:0009267]; development of symbiont in host [GO:0044114]; DN... | nucleus [GO:0005634]; transcription repressor complex [GO:0017053] | DNA-binding transcription repressor activity [GO:0001217]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; transcription corepressor activity [GO:0003714] | PF08581;PF00400; | 1.20.5.340;2.130.10.10; | null | null | null | null | null | null | null | null | FUNCTION: Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of t... | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
P0CY46 | EGFR_APIME | MYNNYNLCHIRTINWEEIITGPSAMYSYVYNFTSPERACTPCDKSCEQGCWGEGPENCQKYSKTNCSPQCWQGRCFGPNPRECCHLFCAGGCTGPKQSDCIACKNFFDDGVCTQECPPMQKYNPTTYSWEPNPDGKYAYGATCVRRCPEHLLKDNGACVRSCPPKKKALNGECVPCDGPCPKTCKGVEKVHSGNIDSFKDCTIIEGSITILDQSFQGFQHVYRNFSFGKRYEKMHPDKLEVFSTLKEITGFLNIQGDHKDFKNLSYFRNLEVIGGRTLTEYFASLYVVKTSLVSFGLSSLKKIYSGSIAILENKNLCYAQ... | 2.7.10.1 | null | ERBB signaling pathway [GO:0038127]; negative regulation of apoptotic process [GO:0043066]; neurogenesis [GO:0022008]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; regulation of cell communication [GO:0010646]; regulation of signaling [GO:0023051]; reproduction [GO:00... | basal plasma membrane [GO:0009925]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] | PF00757;PF14843;PF07714;PF01030; | 3.80.20.20;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU100... | null | null | null | null | FUNCTION: Upon binding to its ligands, transduces the signal through the ras-raf-MAPK pathway and is involved in a myriad of developmental decisions (By similarity). Involved in the determination of adult size, ovary development, and development timing, especially during queen determination of honeybee larvae. May have... | Apis mellifera (Honeybee) |
P0CY48 | UCRI_RHOCA | MSHAEDNAGTRRDFLYHATAATGVVVTGAAVWPLINQMNASADVKAMSSIFVDVSAVEVGTQLTVKWRGKPVFIRRRDEKDIELARSVPLGALRDTSAENANKPGAEATDENRSLAAFDGTNTGEWLVMLGVCTHLGCVPMGDKSGDFGGWFCPCHGSHYDSAGRIRKGPAPRNLDIPVAAFVDETTIKLG | 7.1.1.8 | COFACTOR: Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster per subunit.; | null | plasma membrane [GO:0005886] | 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121] | PF00355;PF10399; | 2.102.10.10;1.20.5.510; | Rieske iron-sulfur protein family | null | SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. | CATALYTIC ACTIVITY: Reaction=a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out); Xref=Rhea:RHEA:11484, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:132124; EC=7.1.1.8; | null | null | null | null | FUNCTION: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | Rhodobacter capsulatus (Rhodopseudomonas capsulata) |
P0CY66 | O168_CONBU | AEDSRGTQLHRALRKATKLSESTRCKRKGSSCRRTSYDCCTGSCRNGKCG | null | null | null | extracellular region [GO:0005576] | calcium channel regulator activity [GO:0005246]; ion channel inhibitor activity [GO:0008200]; toxin activity [GO:0090729] | null | null | Conotoxin O1 superfamily | null | SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21266071}. | null | null | null | null | null | FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin selectively and potently inhibits depolarization-activated rat Cav2.2/CACNA1B currents (IC(50)=89 nM), when coexpressed with alpha-2/delta-1 (CACNA2D1) and beta-3 (CACNB3) subunits. In vivo, is ... | Conus bullatus (Bubble cone) |
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