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S0021967319309471 | An untargeted and pseudotargeted metabolomic combination approach was developed to identify reliable and stable differential markers which can distinguish between pork meat from live pigs conventionally butchered and pork meat from dead pigs butchered immediately after death from diseases or other abnormalities . In th... | Metabolomics for distinguishing live from dead pork meat was firstly developed. Untargeted and pseudotargeted metabolomics determined 14 differential markers. Some differential markers were identified as carnosine. carnitine. histidine. Approach was accurate in quantification to exclude the false positive metabolites. ... |
S0021967319309483 | Therapeutic antibodies can elicit an immune response through different mechanisms either cell independent via complement activation or through activation of immune effector cells . After target binding the Fc part of the antibody will interact with Fc receptors on the surface of effector cells leading to activation and... | Fully fucosylated mono fucosylated and a fucosylated IgGs were separated. Mono and a fucosylated IgGs had equivalent biological activity. Relative peak area of FcRIIIa chromatography correlated to fucose content. High throughput label and modification free screening of IgG producing clones. |
S0021967319309501 | Several issues are associated with the use of high performance liquid chromatography diode array detector analysis in the evaluation of the chemical equivalence of traditional Chinese medicine such as the choice of representative wavelengths quick and efficient integration correct matching of different components and f... | A data handling technique targeted at raw data generated by HPLC DAD. Projection profiling was used to improve the chromatographic information extraction. All of the peaks were verified using the spectral similarity and peak purity. The solvent noise was eliminated using a Whittaker smoother. A computer based strategy ... |
S0021967319309513 | Biomass burning emissions are a significant source of particles to the atmosphere especially in the Southern Hemisphere where the occurrence of anthropogenic and natural wild fires is common . These emissions can threaten human health through increased exposure whilst simultaneously representing a significant source of... | An IC TSQ MS method was developed for the analysis of biomass burning BB markers. BB markers LODs are the lowest reported up to date for an IC MS method. First use of lithium cationisation for BB markers analysis in aerosol samples. Method applicability demonstrated analysing 40 atmospheric samples. Acid washed W41 cel... |
S0021967319309537 | Mussel inspired polydopamine based materials are attractive as stationary phase for open tubular capillary electrochromatography due to their many fascinating properties . However all of the existing strategies for fabricating PDA based OT CEC columns are limited in aqueous solutions . Consequently it is a challenge wo... | A novel PDA ODA co deposited capillary column was developed. ODA was one step immobilized in PDA modified column via organic amine inducing co deposition. The tested analytes were well separated on the PDA ODA co deposited column. The PDA ODA co deposited capillary exhibited great stability and repeatability. |
S0021967319309550 | This work investigates the applicability of on line extraction directly coupled to liquid chromatography for the dynamic extraction of hydrophobic organic compounds from complex solid samples . The method operates within the existing apparatus of the LC by replacing the valve loop with an extraction vessel comprised of... | OLE LC is applied to the extraction of hydrophobic compounds in complex samples. Optimization of chromatographic and extraction conditions is described. Some technical aspects of OLE LC are elucidated. Quantification of UV filters in soils and sediments is demonstrated. |
S0021967319309562 | A wide pore diphenyl stationary phase was evaluated for the analysis of monoclonal antibodies comparing a conventional mobile phase of acetonitrile water containing overall 0.1 trifluoracetic acid with a similar mobile phase incorporating in addition 5 butanol . Alternatively TFA was replaced by ammonium formate buffer... | Diphenyl bonded 1000 column evaluated for separation of monoclonal antibodies. Rituximab and Bevacizumab selected as difficult probes. Column was tested with trifluoroacetic acid and a variety of additives. Ammonium formate is mass spectrometer friendly with acceptable results at 70C. Methanesulfonic acid gives best pe... |
S0021967319309574 | Modified micellar liquid chromatography with a natural deep eutectic solvent produced from choline chloride and ethylene glycol was employed for melamine monitoring in milk matrix . This sustainable mobile phase was attained through chemometrical optimization of crucial variables including concentration of sodium dodec... | Introducing a sustainable mobile phase for melamine monitoring in milk samples. Great performance of natural deep eutectic solvent as the chromatographic modifier. Efficient chromatographic retaining of melamine in short analysis time. Melamine analysis in milk samples without any interfering with coexisting proteins. ... |
S0021967319309586 | A metal organic framework material MIL 101 was developed as an effective solid phase extraction adsorbent for the extraction of eleven UV filters compounds . The MIL 101 adsorbent was packed into a polypropylene cartridge and connected at the outlet tip with the Visiprep vacuum manifolds allowing process up to 12 port ... | Multiclass UV filter analysis in environmental and recreational waters by SPE GCMS MS. MIL 101 is proposed for the first time as a miniaturized on column SPE adsorbent. The extraction procedure was extensively optimized by experimental design. Good recoveries precision and low LOD at the ngL. were achieved. Real water ... |
S0021967319309598 | One of the main steps in designing preparative chromatographic separation units is the selection of a well performing adsorbent . This is often based on expert knowledge or based on case studies of preselected adsorbents . Therefore the selection is usually limited in terms of an optimised choice . In this contribution... | Mathematical correlations between structural resin property and model parameters. Model based prediction of an optimal degree of cross linking. Novel method to include the chromatographic system in optimisation algorithms. |
S0021967319309604 | Analysis of acrylamide in coffee by liquid chromatography tandem mass spectrometry is prone to interferences . According to our study unknown background ions can entail an overestimation by up to 40 in case of coelution with acrylamide . In order to develop a precise and accurate quantification method for acrylamide id... | Acetyl alanine was identified as an interference of acrylamide in coffee. An in source fragment of. acetyl alanine is interfering with acrylamide signal. Overestimation can reach 40 if acrylamide coelutes with. acetyl alanine. Mobile phases without modifier allow an interference free acrylamide analysis. |
S0021967319309616 | Qualitative and quantitative determination of volatile markers in aqueous based fragrances assumes ever increasing importance because of both the need for quality control and the safety regulatory limitations introduced for several compounds . This study reports and critically discusses the results of applying new wate... | Direct GCMS quantitative analysis of aqueous samples with water compatible columns. Injection conditions were optimized to obtain reliable and repeatable results. Narrow bore columns were adopted to minimize the amount of water in the MS. Reliability of the results was proved by determining volatile allergens in perfum... |
S0021967319309628 | Polarimetric HPLC detector was used to acquire chromatograms for lavender lavandin essentials oils on different chiral stationary phases . Amylose tris immobilized on silica allowed the best separation of the numerous chiral phytomarkers and was thus used to obtain a chiroptical fingerprint for 158 samples of French la... | Differentiation of varietal origins of French lavender lavandin essential oils. Characterization of essential oils using chemometrics and chiroptical fingerprints. Polarimetric detector was used to obtain chiroptical fingerprints. Characterization of essential oils by their chiral markers. Chiral chromatography with po... |
S002196731930963X | The conversion of lignocellulosic biomass is a major challenge in the field of renewable energies and bio based chemicals . The diversity of biomasses and processes leads to complex products having a wide range of polarities and molecular weights . Nowadays the molecular description of these oxygenated matrices is stil... | Characterization of an industrial lignocellulosic biomass sample. Selective and controlled multi step liquidliquid fractionation. High resolution mass spectrometry hyphenated to liquid chromatography. Structural elucidations with multi stage fragmentation experiments. |
S0021967319309641 | A major strength of capillary electrophoresis is its ability to inject small sample volumes . However there is a great mismatch between injection volume and sample volumes . Electromigration based sample preparation methods are based on similar principles as CE . The combination of these methods with capillary electrop... | Three phase electroextraction was coupled directly to capillary electrophoresis. A new method for sensitive analysis of biogenic amines was developed. Application of the method to urine shows promise for use in metabolomics. |
S0021967319309653 | A chromatographic system was adapted to allow monitoring of eluent of preparative column via absorbance and with the chromatographic analysis of the target macromolecule on the same chromatographic system . The proposed approach was tested on important macromolecules such as monoclonal antibodies monoclonal antibody ag... | Monitoring the effluent of the preparative column by rapid chromatography on a single chromatographic system. Fast chromatographic analysis was allowed at low pressure using convection based chromatographic columns. Limit of detection can be tuned by sample loop and variable number of injections. Typical method accurac... |
S0021967319309665 | Recently it has been reported that immobilized chlorinated type chiral stationary phases based on cellulose tris are able to express an outstanding enantioselectivity towards the structure of 2 benzamide . We now introduce two homologue series of chiral sulfoxides based on the same 2 benzoyl core as the prototype of ne... | This paper describes the HPLC behavior of two sets of chiral sufoxides on the IC 3 and IC CSP. The analytes contain different alkyl groups Me Et n Pr n Bu and n Pe . The role of the alkyl groups on retention and enantioselectivity was demonstrated. The thermodynamic aspects of enantioseparations were investigated. The ... |
S0021967319309677 | A direct procedure based on thermal desorption gas chromatography tandem mass spectrometry was developed for the fast extraction of seven polychlorinated biphenyls from sediments and soils . PCBs were directly extracted from 20 to 75mg of sample without any chemical pre treatment or use of organic solvents after the ad... | TDGCMSMS has been proposed for the automated and direct extraction of PCBs from soil and sediment. Extraction time and solvent consumption is assumed to be close to zero. A certified reference material was analysed with comparable results. Field sample results were comparable with those obtained by a reference extracti... |
S0021967319309690 | Improvements in sample preparation separation and mass spectrometry continue to expand the coverage in LC MS based lipidomics . While longer columns packed with smaller particles in theory give higher separation performance compared to shorter columns the implementation of this technology above commercial limits has be... | 1550cm columns operated up to 35kpsi for lipid separations. Chromatographic peak capacities over 400 for lipid extract from human plasma. Putative lipid identification of nearly 500 lipids from human plasma extract. Resolution of regional and geometrical lipid isomers. |
S0021967319309707 | Countercurrent chromatography is a unique support free liquid liquid partition chromatography . Since it was invented by Y. Ito in 1960s CCC has been widely accepted and applied as popular separation and purification technique for natural and synthetic complex . However up to date there is little study to address on hy... | Hydrophobic and hydrophilic interactions in CCC have been first highlighted. Hydrophobic interaction in CCC leads to larger. values and longer retention time. Hydrophilic interaction in CCC results in smaller. values and shorter retention time. Some solvents or additives may enhance hydrophobic or hydrophilic interacti... |
S0021967319309719 | Ultraviolet radiation from sunlight causes DNA damage in skin cells by formation of photoproducts mainly cyclobutane pyrimidine dimers which are reverted by exogenous CPD photolyase preventing photoaging and skin cancer . High performance liquid chromatography tandem mass spectrometry method for quantification of CPD p... | Method development for CPD photolyase activity quantification by UHPLCMS. Ion pair reagent allowed separation of CPD and 15mer oligonucleotide in C18 column. Sensitive and selective method with reduced analysis time. CPD photolyase activity in purified and crude extract was performed. |
S0021967319309732 | The application of chiral ionic liquids in capillary electrophoresis for enantioseparation has received considerable attention in the past few years however the use of chiral ILs as ligands in ligand exchange capillary electrophoresis has been reported only in a few papers . In this work several tetraalkylammonium amin... | Three TAA AAILs were first applied in LE CE to act as chiral ligands. TMA. Arg showed significant superiority compared with most reported AAIL ligands. Most analytes were enantioseparated with satisfactory Rs in short migration times. Factors influencing the novel LE CE method were systematically investigated. |
S0021967319309744 | The feasibility of measuring the aging and degradation of PBX 9501 via online two dimensional liquid chromatography is investigated and a preliminary instrumental setup and method is developed . Plastic Bonded eXplosive 9501 is nominally composed of 94.9wt HMX 2.5wt Estane 5703 2.5wt BDNPA F 0.1wt Irganox 1010 and PBNA | Viability of 2D LC for analyses of aged plastic bonded explosives PBX is explored. 2D LC method with RPLC in. D and SEC in. D using a comprehensive setup LCLC . A simple sample preparation is proposed. Various SEC and HPLC experimental parameters are explored for analysis of PBX 9501. Demonstrated potential of LCLC on ... |
S0021967319309768 | Retention rules are well known in liquid chromatography . For the mobile phase composition retention decreases when adding organic solvent to water for reversed phase or increasing water proportion for hydrophilic interaction liquid chromatography and a decrease in temperature usually increases retention . For supercri... | Effects of backpressure and temperature changes in SFC with varied modifier percentages. Expected and surprising retention behaviors on polar nonpolar and aromatic phases in SFC. Subtle effects of particle modifications or isopropanol used on retention behaviors. |
S002196731930977X | Isomers derived from natural products are promising candidates for drug discovery . However characterization of isomers by mass spectrometry especially stereoisomers and positional isomers remains a large challenge due to insufficient reference standards and isomers highly similar fragmentation pathways or nondistincti... | A new strategy was developed to screen metabolites and discriminate isomers. Phenylethanoid glycosides and their isomers from. were elucidated. Fingerprint analysis coupled chemometrics was used for isomers discrimination. 101 compounds including 14 isomers were identified or putatively characterized. |
S0021967319309781 | A headspace solid phase microextraction Arrow method coupled with gas chromatography mass spectrometry was developed for the quantitation of a large number of aroma compounds in Chinese liquor . Optimization of extraction conditions by a central composite experimental design revealed that the dilution of the alcohol co... | HS SPME Arrow sampling developed for volatile aroma compound extraction in Baijiu. HS SPME Arrow fiber affords improved extraction efficiency than that of SPME fiber. Multivariate methods including RSM were used to optimize the HS SPME Arrow method. A method for quantitation of the 82 volatile compounds in Baijiu was e... |
S002196731930980X | It has been known that anion exchangers prepared by grafting poly onto Sepharose FF at ionic capacities over 600mmol L show both high protein adsorption capacity and uptake kinetics and charge reversal of PEI Sepharose by modification with succinic anhydride can produce protein cation exchangers of high capacity and up... | PEI Sepharose was modified via two different routes to derive cation exchangers. They are. and. routes. The. route showed a complex reaction mechanism. resins showed superior properties over the others. |
S0021967319310039 | We discuss several possible phenomena in electrophoretic systems with complexing agents present in the background electrolyte . In our previous work we extended the linear theory of electromigration with the first order nonlinear term which originally applied to acid base equilibria only by generalizing it to any fast ... | Linear theory of electromigration explained for EKC for the first time. New software PeakMaster 6 validated on experimental data in EKC. The well known Tiselius and Wren and Rowe s equations re examined. Changes in selector concentration inside the analyte zone inspected. Dependence of system peaks mobility on selector... |
S0021967319310040 | Lecithins are phospholipidic mixtures that can be part of microemulsions and liposomes . In this work ready to use preparations of lecithin have been tested as pseudostationary and mobile phases in EKC and LC respectively . The selectivity of two EKC systems one based on lecithin microemulsions and another on liposomes... | Volume and H bond basicity of solutes drive partition in lecithin chromatography. Solutes partition in LC and EKC systems containing phospholipids is similar. Lecithin based chromatography emulates skin partition in a fast cheap and easy way. |
S0021967319310052 | The incorporation of ion mobility into LCMS analysis has been demonstrated to result in the generation of superior quality MS and MS MS spectral data as well as providing enhanced resolution in the IM dimension based on lipid class . Here a sub 4 min microbore LC ion mobility accurate mass MS method has been developed ... | A rapid microbore UHPLCIMMS method for profiling lipids is described. This provides lipid class separation a 75 reduction in solvent usage and run time. Plasma extracts showed differences between controls and breast cancer patients. Reduced PC TAG and DAG concentrations and higher PS expression in study samples. Coeffi... |
S0021967319310064 | In the nutrition field there is a lack of understanding about the impact that dietary chiral composition may have on health especially regarding cooked meals . Chiral amino acids are naturally present in food and their proportion may vary quite a lot . Besides the | Optimization of an LCMS MS method for absolute quantitation of 17. AAs in food. Validation of the method with cooked meals and LLOQ are 2.0ng mL for most of them. Application of the method to healthy breakfast lunch and dinner meal samples. Absolute levels of D AAs are given per daily food intake and within each main m... |
S0021967319310088 | Four polar stationary phases have been characterized in supercritical fluid chromatography by linear free energy relationships method with an extended set of Abraham s descriptors . Temperature 2555 | Four polar stationary phases have been characterized in SFC by LFER method. Temperature and pressure effects on retention of 89 test compounds were studied. Temperature and pressure variations lead to small but traceable changes in LFER coefficients. The direction and scale of temperature effects depend on stationary p... |
S002196731931009X | X ray computed tomography has been demonstrated to be capable of imaging 1mL chromatography packed beds under compression visualising the 3D structure and measuring changes to geometry of the packing . 1mL pre packed columns did not exhibit any structural changes at vendor specified flow rate limits however cellulose b... | 1mL pre packed beds imaged under compression using X ray CT. Digital erosion dilation approached compares porosity tortuosity relationship. Cellulose and ceramic materials investigated at both scales. Porosity tortuosity permeability and diffusivity quantified using 3D structure. |
S0021967319310106 | A high performance thin layer chromatography method was developed for rapid and easy to perform discrimination between five goldenrod species present in Europe the native | New HPTLC based approach for distinction of goldenrod. species. First cholinesterase diabetes and bacterial inhibitory potential of compounds. Labdane diterpenes and polyacetylenes as multipotent bioactive compounds. HPTLC EDA combined with DART HRMS and HPTLC ESI HRMS MS. Preparative scale bioassay guided isolation of... |
S0021967319310118 | Molecularly imprinted polymers with tailor made recognition sites are used in water analysis for selective sample pretreatment before quantitation . The exceptional performance of MIPs with reduced interferences and matrix effects during sample preparation has resulted in selective and precise analytical methods by enh... | MIP sorbents have been widely used for selective extraction in sample preparation. A critical evaluation of MIPs in the analysis of environmental waters is provided. Selectivity and efficiency of MIPs are evaluated regarding rebinding medium. The limitations of MIPs for water analysis are assessed. Direct and online an... |
S002196731931012X | From the analytical chemistry point of view an ideal sample preparation method should be simple rapid automatic selective precise exhaustive reproducible and protect the analyte of interest from degradation . In this study a novel sample preparation method named pressurized matrix solid phase dispersion | A novel and advanced sample preparation methodology. MSPD was proposed. The. MSPD was performed with LC MS instrument. The. MSPD can simultaneously extract separate purify isolate and analyze endogenous components. The. MSPD allowed for isolation of some pure compounds with MS guided fractionation. Subsequent NMR analy... |
S0021967319310131 | The petroleum industry is increasingly concerned with the conversion of vacuum residues as a consequence of decreased conventional crude oil availability . The compositional analysis of heavy oil products has become a key step in conversion processes but the complexity of these oil matrices tends to increase with their... | SECxRPLC was successfully applied to complex petroleum samples. Detection by ICP MS MS allowed to simultaneously analyze S Ni and V. Information on both MW and hydrophobicity was obtained within a single run. An effective peak capacity of 2600 was achieved in 150min in off line SECxRPLC. On line RPLCxSEC was evaluated ... |
S0021967319310143 | A rapid synergistic cloud point extraction for nine alkylphenols coupled with high performance liquid chromatography and fluorescence detection was developed . The non ionic surfactant polyethylene glycol 6000 was selected as the extractant . Acetonitrile was used as a revulsant and synergistic reagent with Na | A rapid synergistic cloud point extraction was first developed for alkylphenols. Acetonitrile worked as a new revulsant and synergic reagent in this study. The CPT of PEG 6000 was decreased to ambient temperature by acetonitrile and sodium sulfate. BoxBehnken design with the desirability function was used to optimize t... |
S0021967319310155 | Gas chromatography and vacuum ultraviolet spectroscopy are powerful and complementary techniques for the analysis of small molecules in forensics . Most notably flame ionization detection is commonly used with GC to identify and quantify volatile compounds . An FID s price point and ease of use makes it an attractive a... | Gas chromatography vacuum ultraviolet spectroscopy for blood alcohol inhalants. Vacuum ultraviolet spectroscopy provides authoritative identification of compounds. Spectral deconvolution allows for accurate quantitation of coeluting peaks. |
S0021967319310167 | Mechanistic modeling of protein adsorption has gained increasing importance in the development of ion exchange chromatography processes . The most common adsorption models use a stoichiometric representation of the adsorption process based on the law of mass action . Despite the importance of these models in model base... | A non stoichiometric adsorption model for IEC chromatography is derived. Adsorption is governed by electrostatic interactions inside an interaction force boundary layer. The model accounts explicitly for ionic strength and pH based on the protein primary structure. Model parameters are theoretically valid on different ... |
S0021967319310180 | In this work the use of design of experiments and posterior data modelling by artificial neural network and least squares is presented as a suitable analytical tool for the performance optimization of a tandem mass spectrometric detector coupled to ultra high performance liquid chromatography for the analysis of sevent... | Efficient optimization of MS MS parameters by means of design of experiment. Performance evaluation of data modeling by least squares and neural network. Accurate model prediction of seventeen veterinary drugs with results ranging from 85 to 125 . Advantages of 54 reduction in laboratory time and 80 in analyte waste. |
S0021967319310192 | This study presents the development of an efficient extraction protocol for amoxicillin from plasma with improved solubility and stability using pH control . Solubility and stability of amoxicillin in commonly used extraction solvents were determined using a newly developed stability indicating high performance liquid ... | Solubility and stability of amoxicillin was improved by the addition of a buffer. The extraction of amoxicillin from plasma was enabled via pH control. A stability indicating HPLC assay enabled the analysis of amoxicillin in plasma. Pharmacokinetic analysis validated the extraction protocol. |
S0021967319310209 | This paper proposed an accurate and sensitive analytical method based on the combination of Liquid Chromatography Quadrupole Time of Flight Tandem Mass Spectrometry system with Quadruple Isotope Dilution Mass Spectrometry ID | An accurate and precise method was developed for determination of diuron. The LOD and LOQ values were found to be 14.6 and 46.5gkg. respectively. ID. MS strategy was implemented after the synthesis of diuron d6. Developed method was applied to seaweed samples with satisfactory percent recoveries. |
S0021967319310222 | Nintedanib is a tyrosine kinase inhibitor recently approved for the treatment of idiopathic pulmonary fibrosis . As a new drug no monograph is available so far in official compendia . A liquid chromatography tandem mass spectrometry method is presented for the simultaneous determination of NIN and its seven potential i... | A LC MS MS method for the assay of nintedanib and its impurities was developed. Method development was carried out by Analytical Quality by Design approach. A 35 16 symmetric matrix was used in the screening phase. Box Behnken Design allowed the contour plots to be obtained. Method operable design region was defined by... |
S0021967319310246 | As an endogenous nucleoside adenosine was significant for the diagnosis and treatment of some diseases such as schizophrenia . However due to the complicated matrix interference it was difficult to monitor trace or ultra trace adenosine directly in bio samples . In this contribution a novel in tube SPME technique based... | An aptamer AuNPs coated in tube solid phase microextraction capillary was prepared. 2.84gcm. of the bonding amount of Au coated on the inner surface was obtained. 2.44g of aptamer immobilization capacity was obtained in a 27 cm capillary. Aptamer AuNPs coated capillary showed improved selectivities to adenosine. Adenos... |
S0021967319310258 | In this study a monolithic enzyme reactor based on a strategy of green synthesis was successfully prepared in a capillary with trypsin immobilized by thiol ene click reaction . A polymer of poly butyl methacrylate | IMER based on deep eutectic solvent was prepared by thiol ene click reaction. Michaelis constants and maximum reaction rate were 2.1mM and 0.028mol min. A rapid digestion of BSA on the IMER was 864 times faster than in solution digestion. 1034 protein groups can be identified from protein extracts of rat liver by the I... |
S002196731931026X | Iron free HPLC systems better known as biocompatible systems are generally regarded to be chemically more inert compared to conventional HPLC systems . In this work we studied the chromatographic behavior of some classes of compounds of pharmaceutical interest analyzed with iron free systems . Issues typically associat... | Methanol acetonitrile solvent causes titanium corrosion. Titanium leaching from biocompatible HPLC can cause peak tailing. Peak tailing can be caused by the formation of complexes with immobilized titanium. |
S0021967319310295 | An accurate quantification of phenolic compounds present in several kind of craft beers corresponding worts ingredients and spent products was performed by LCMS MS in this study . The dilution 1 2 of the sample with the mobile phase gave the best results offering a very fast and simple method to reduce the matrix effec... | An accurate quantitative analysis of craft beers by LCMS MS identified phenolic acids and flavonoids mostly coming from malt and bitter acids and prenylflavonoids coming from hop. Dilution 1 2 of the sample with the mobile phase offered a very fast and simple method to minimize the matrix effect. Most polyphenols are a... |
S0021967319310301 | Wastewater based epidemiology is a growing research field which provides valuable information on community drug use and chemical exposure . One parameter critical to estimations of drug use is the catchment area population . A population biomarker could be used to provide this information . This study evaluated the ana... | Development of a UHPLC MS MS method for neurotransmitter metabolites in wastewater. Derivatization substantially enhanced sensitivity for 5 HIAA and HVA. Low inter day mass load variability for 5 HIAA HVA and VMA was measured. HVA and VMA followed transient population changes in wastewater during a festival. |
S0021967319310313 | agonists which have been illegally used in animal production in some countries can induce bioaccumulation when blood is converted by rendering into blood meal . Unfortunately available data on this topic are scarce which result in lack of risk assessment . Therefore in this research a method for simultaneous determinat... | A new method for analysis of 22 agonists in blood meal was developed. The method was successfully applied to analyze agonist in blood meal. agonist residues in process and stored blood meal have been studied firstly. |
S0021967319310325 | Jumonji domain containing proteins play an important role in the epigenetic regulation of gene expression . Aberrant regulation of histone modification has been observed in the progression of a variety of diseases such as neurological disorders and cancer . Therefore discovery of selective modulators of JMJDs is very a... | We developed a CE method for screening of histone demethylase JMJD3 inhibitors. The method is straightforward and robustness. Coating the capillary with a positively charged polyelectrolyte is necessary for the method. Salvianic acid a and puerarin 6 O xyloside were identified as new JMJD3 inhibitors. |
S0021967319310349 | This work presents the investigation of utilizing adenine functionalized polypropylene glycol for capillary gas chromatographic separations . The statically coated APPG column showed moderate polarity and high column efficiencies of 4660plates m and 4376plates m determined by | Adenine functionalized polypropylene glycol. High resolution of the Grob test mixture and the isomers of anilines and phenols. Simultaneously improved column selectivity and inertness. Advantageous performance over conventional stationary phases. |
S0021967319310362 | The purpose of this work was to compare side by side the performance of packed bed and membrane chromatography adsorption processes for protein purification . The comparison was performed using anion exchange media with the same ligand immobilized on the adsorbing surface namely the strong Q quaternary ammonium group R... | Direct comparison between membrane and packed bed column. Packed bed has higher binding capacity. The difference decreases significantly at increased superficial velocity. Membrane adsorber capacity is flow rate independent by a variety of measures. At low residence times the membrane adsorber outperforms the packed co... |
S0021967319310374 | Authentication of original species is embedded in the quality control system of herbal medicines . In this work ultra performance liquid chromatography quadrupole time of flight mass spectrometry based untargeted metabolomics coupled with chemometric analysis was utilized for the precise authentication of the | A stepwise analysis approach was proposed to enlarge differences among species. Species specific markers of eight. species were firstly discovered. species in 16 commercial pharmaceutical products were authenticated. |
S0021967319310611 | A microextraction technique termed promoted reaction microextraction based on a liquid liquid microextraction was developed by applying a chemical reaction for promoting the extraction of the analytes into the extracting solvent . PRME is a very simple rapid and high performance method for extraction and pre concentrat... | A simple rapid and high performance pre concentration is represented. The pretreatment involves a LLME in which a gas generation reaction occurs. The produced gas bubbles from acid base reaction promote the transfer of the analytes onto the extracting phase. The PRME allows the simultaneous quantification of pesticides... |
S0021967319310623 | Sample preparation of complex matrices like food samples continues to be a challenge demanding great effort for improvements . In this study a new technique named balls in tube matrix solid phase dispersion is proposed based on a simplification of the conventional MSPD technique being all sample preparation performed d... | A novel BiT MSPD technique was developed for first time for pesticides extraction from fruits. BiT MSPD is fast easy to perform and tools are cheap and very accessible. The use of balls improved the method efficience when compared to official methods. Practical method limit of quantification for 133 pesticide residues ... |
S0021967319310635 | Eicosapentaenoic acid and docosahexaenoic acid are essential omega 3 fatty acids in human nutrition . Dietary supplements containing these FA are available in the market and there is a need to assess their quality to prevent frauds . The purpose of this work was to optimize and validate a fast capillary electrophoresis... | A fast CE method was optimized and validated for omega 3 oil supplements. Analysis was completed in just 8min requiring only a prior saponification step. LOD LOQ linearity accuracy and repeatability tests were considered to validation. No significant differences were found between this approach and classic method. This... |
S0021967319310647 | When assessing occurrence and exposure to toxic chemicals in drinking water developing methods that are sensitive and efficient is paramount . A new method was developed for the quantification of ten halobenzoquinones a class of disinfection by products in drinking water which have been shown to be more toxic than most... | A novel method analyzing ten halobenzoquinones was developed. Automation resulted in increased efficiency for high throughput analysis. Quality control measures resulted in limits of quantification that are highly reproducible. Higher bromide to HOCl ratios increased formation of brominated halobenzoquinones. Highest c... |
S0021967319310659 | Chlorophyll pigments give the green colour to plants which is a quality attribute of food and vegetables . However the chemical structure of native chlorophyll can change during varied processes applied to plants which produce degradation compounds that could have a brown and unwanted colour . | Retention behaviour of chlorophyll and chlorophyll derivatives by SFC using varied modifiers. Improved separation of hydroxy pheophytins. and. and their epimeric forms. Method development of phytylated chlorophyll derivatives with the use of C18 stationary phase. Unusual conditions of backpressure for mobile phases con... |
S0021967319310660 | This paper presents a basic model of an automated system for predicting the detection limit and precision profile of measurements against concentration in chromatography . The fundamental assumption is that the major source of response errors at low sample concentrations is background noise and at high concentrations i... | A mathematical theory to describe the SD of measurement errors was developed. An automated system to validate a quantitative HPLC was proposed. The distinction between noise and signal was mathematically achieved by this system. The DL and precision profile were given to a signal by the laboratory made software. The la... |
S0021967319310684 | A novel combined vortex assisted dispersive liquid liquid microextraction micro solid phase extraction procedure for polycyclic aromatic hydrocarbons in ambient fine particulate matter of aerodynamic diameter of 2.5m PM | A combined microextraction procedure VA DLLME SPE was developed. PAHs associated with ambient air particulate matter PM. were determined. The PAH levels were determined using GC MS MS. The method showed good extraction efficiency. |
S0021967319310696 | Aldehydes originating from malt play an important role in beer flavour deterioration . In order to better understand the influence of malting process on beer staling it is necessary to acquire a reliable analytical methodology for determination of beer staling aldehydes in malt . Therefore the aim of this study was to ... | Evaluating sample preparation for a fast quantification of aldehydes in pale malts. Malting technology influences the content of beer staling aldehydes in pale malts. Quantity of beer staling aldehydes introduced into the brewing could be controlled. |
S0021967319310714 | A high performance liquid chromatography method equipped with a boron doped diamond electrode was established for the simultaneous determination of phenol 4 ethylphenol guaiacol 4 ethylguaiacol 4 vinylguaiacol eugenol and | Efficient reversed phase separation and sensitive detection of 9 key flavoring phenolic compounds including guaiacol and phenol in whiskey using a core shell column with ECD at a BDD electrode. The BDD electrode with anti fouling properties and extended potential windows provided excellent detection sensitivity and sel... |
S0021967319310726 | The applicability of models to describe peptide retention in hydrophilic interaction liquid chromatography was investigated . A tryptic digest of bovine serum albumin was used as a test sample . Several different models were considered including adsorption mixed mode exponential quadratic and NeueKuss models . Gradient... | Five models were studied and compared for modelling retention of peptides in HILIC. Most suitable additives were established for three different types of HILIC columns. Models were compared using AIC values with the adsorption model performing best. The significance of model terms was studied using the F test for regre... |
S0021967319310738 | Most of the reported covalent organic frameworks are hydrophobic limiting their adsorption application in sample pretreatment field . In this work sulphonate functionalized magnetic covalent organic frameworks composites were first synthesized by loading gold nanoparticles on Fe | Functionalized magnetic covalent organic framework composite was facilely prepared. Magnetic composites were employed for highly effective fluoroquinolones enrichment. MSPE HPLCMS MS method was developed for fluoroquinolones detection in food samples. |
S002196731931074X | Haloacetic acids are the second largest class of disinfection by products by weight in water and are more cytotoxic and genotoxic to mammalian cells than trihalomethanes the first largest class of DBPs . Gas chromatography is the most widely used technique for determining HAAs . Due to their polar nature derivatization... | Presence of HAMs interfered with determination of HAAs using GC. Transformation rate of HAMs to corresponding HAAMEs ranged from 6.5 to 45.7 . Direct conversion of HAMs to corresponding HAAMEs caused the interference. A method for revising HAA concentrations in the presence of HAMs was proposed. |
S0021967319310751 | We introduce an integrated chip approach for a postcolumn segmentation of normal phase liquid chromatography . This is achieved by the seamless integration of a chiral NP chip HPLC column a flow focusing droplet generator and a segmented flow channel in a single microfluidic glass chip . This allows a continuous segmen... | Pioneering work joining normal phase chip HPLC and droplet microfluidics. Integration of a packed NP HPLC column and a droplet generator in glass chips. Ethylene glycol works as polar continuous phase. heptane eluent compartmentalized with moderate droplet frequencies. |
S0021967319310763 | Cyclodestrins are cyclic oligosaccharides well known for their ability to form host guest inclusion complexes with properly sized compounds . They have been used for decades as chiral selectors as well as drug delivery systems within the frameworks of separation science and pharmaceutical science . More recently their ... | Classes of cyclodextrin based sorbents for solid phase extraction are illustrated. Advantages and shortcomings of each sorbent typology are discussed. Latest applications of these materials are presented. Future trends in preparing advanced cyclodextrin based sorbents are identified. |
S0021967319310775 | For a wide variety of hydrophilic interaction chromatography stationary phases a repeatable partial equilibration was demonstrated in gradient elution after purging with as little as 12 column volumes of mobile phase . Relative standard deviations of retention time of on average 0.15 could be obtained after 1 or 2 cond... | Repeatable partial gradient elution equilibrium shown for different HILIC columns. Rapid partial equilibration independent of stationary phase and gradient slope. Full equilibration time depends on water layer thickness on stationary phase. Full equilibration faster at elevated temperature and increased column pore siz... |
S0021967319310787 | Pesticide residue analysis in cannabis has become a subject of growing interest in North America since recent legalization in Canada and decriminalization for medicinal or recreational use in most US states . To meet regulatory and quality control standards cannabis products should be tested for both authorized and una... | Overview of sample preparation methods. Pros and cons of each technique described. Overview of analytical methods for pesticide residue analysis in cannabis products. Challenges and future directions for pesticide residue analysis in cannabis products. |
S0021967319310805 | Fucoidans represent an intriguing class of fucose containing sulfated polysaccharides . The biological activities of these polysaccharides are related to their compositional and structural parameters whereby their degree of sulfation as well as molecular weight distribution and chain conformation play important roles .... | SEC with multiple detection is useful for structural characterization of fucoidans. Six fucoidans were heterogeneously and complex composed. Six fucoidans considerably differed in their molar mass and size characteristics. Typical fucoidans consisted of expanded flexible chains with branched structure. Molar mass and c... |
S0021967319310829 | Pyrethrum extract is a natural insecticide that has been used worldwide for centuries with pyrethrins being considered active ingredients . Their purification is difficult due to their chemical structural similarity and instability to light . In the present study a coordination complex high speed counter current chroma... | Separation of pyrethrins by High speed counter current chromatography HSCCC for the first time. A coordination complexation method was used to separate pyrethrins. The presence of a silver ion complex agent significantly increased separation factor. |
S0021967319310830 | Untargeted steroid identification represents a great analytical challenge even when using sophisticated technology such as two dimensional gas chromatography coupled to high resolution mass spectrometry GCGC | Data driven approaches for GCxGC retention time predictions. 3D electrostatic potential and CNN were utilized to develop 3D QSRR models. CNN are able to learn geometric information which improves model prediction. Retention time prediction and HRMS information enable untargeted steroid annotation. |
S0021967319310854 | An on line high performance liquid chromatographydiode array detectorelectrospray ionizationion traptime of flightmass spectrometrytotal antioxidant capacity detection system was applied for the identification and evaluation of antioxidants in | An on line system was used to detect the antioxidant activity of. 80 compounds were separated and identified. DPPH and FRAP activities of active compounds were evaluated. 11 samples were analyzed and compared for their activities. |
S0021967319310866 | Oligosaccharides are gaining importance because of their beneficial properties in human health . They normally appear in natural and synthetic products as complex mixtures of different monomeric units glycosidic linkages and degrees of polymerization being disaccharides and trisaccharides usually the most abundant ones... | Chromatographic behavior of 23 disaccharides on HILIC and PGC columns was evaluated. MS. characteristic ions of disaccharides were established by SLDA. Structural characterization of trisaccharides was successfully achieved by SLDA application. |
S0021967319310878 | In spatial multi dimensional liquid chromatography devices the flow of each dimension has to remain in the corresponding region otherwise the separation efficiency is undermined . Adequate flow confinement measures are necessary . Here the use of permeability differences across different compartments of spatial two dim... | Flow control and confinement are necessary in spatial 2D and 3DLC. In 2D. LC devices total spillage under 1 achieved with porous barriers. 3D. LC devices with a highly permeable monolith in the. D and 1m particles in. D. A novel 3D. LC flow distributor is proposed. Design exploration through computational fluid dynamic... |
S002196731931088X | The migration of bisphenols can take place from plastic packaging materials into freshly cooked takeaway food especially at high temperatures . In this study cetyltrimethylammonium bromide | had been prepared by a one pot hydrothermal method. was used as adsorbent for dispersive solid phase extraction of BPs. The migration of BPA and BPAF from plastic packaging materials was test. |
S0021967319310891 | This research focuses on retention mechanisms in a LC column with C18 stationary phase when novel eluent additives are used . The retention factors between novel eluent additives and conventional ones like ammonium acetate and ammonium bicarbonate at different eluent pH values were compared . A simple set of drug like ... | Introduction of 5 novel volatile compounds as eluent additives. Insights to retention mechanisms with ion pairing fluorinated eluent additives. Fluorinated eluent additives aid the retention of bases but reduce it for acids. Promising perspective for drug analysis using LC MS. |
S0021967319310908 | The bottleneck of analytical instrument itself and non ideal instrumental performance will produce a certain degree of drifts between the measured isotopes and the true values . An AAID IC algorithm was thereby proposed to keep the isotopic distributions more accurate in hyphenated instruments e.g . Gas Chromatography ... | Average was automatically performed for all sampling points in. zones. Automatic resolution and calculation for overlapped isotopes. Calibration functions were established from natural references. The corrected values were transformed into an ionic isotopic curve. AAID IC algorithm was developed for any type of GC LC M... |
S002196731931091X | The development and application of non porous and porous sorptive rods comprised of polydimethylsiloxanemicrodiamond composites is reported . The PDMS MD composites were made porous using inorganic salt NaCl and NaHCO | Preparation and purification of porous and non porous PDMS microdiamond composites. Evaluation of unique physical chemical characteristics of the PDMS microdiamond composites. Application of the composites as new sorptive phases for organic chemical analysis. |
S0021967319310921 | Gradient elution in liquid chromatography reduces the analysis time improves the efficiency and increases the peak capacity . The study of this chromatographic mode has been based mainly on kinetic dispersion models . The plate model has been applied to a lesser extent despite being the basis for the concepts of plate ... | The plate model is solved for gradient elution. A general dispersion equation is proposed for isocratic and gradient elution. Gradients with ramp of stationary phase and mobile phase are considered. Peak compression is verified with a ramp of mobile phase within the column. Experimental and predicted values agree satis... |
S0021967319310969 | To fully capture the chemo diversity of medicinal plants is very essential for understanding of their pharmacological activities and guiding scientific quality control . Aiming to facilitate chemical characterization and novel natural products discovery the present study proposed an integrated approach based on two dim... | A HILICRP LC was applied to cover and separate multi type constituents in LJF. A two step MDF induced exclusion list DDA scan method was developed. An automatic matching algorithm was proposed for targeted screening. Molecular networking was applied for structural classification and elucidation. Global characterization... |
S0021967319310982 | Due to the trace levels of polycyclic aromatic hydrocarbons in soil and the complexity of soil matrices effective sample pretreatment methods are of great significance to obtain accurate analytical results . In this paper polydopamine encapsulated Fe | More facile preparation method was employed to synthesize Fe. The prepared material displayed higher selectivity towards PAHs than. alkanes. The new cleanup process required less time adsorbent and solvent consumption. The proposed method had good cleanup efficiency selectivity and accuracy. |
S0021967319310994 | The objective of this paper was to extend comprehensive theoretical and experimental investigations at the molecular level to identify factors responsible for the high selectivity of imprinted sorbents . This knowledge was utilized in a new analytical strategy devoted to the analysis of hordenine in human urine after b... | Highly selective imprinted sorbent for hordenine was constructed. Selective response of material was proved theoretically and experimentally. Characterization of material was provided. Analytical strategy for determination of hordenine was validated. Method was proved by analysis of hordenine in urine after beer consum... |
S0021967319311136 | A novel restricted access media magnetic molecularly imprinted polymers was prepared as magnetic solid phase extraction material for tetracyclines . The RAM MMIPs can not only specifically adsorb target molecules in samples but also effectively eliminate the interference of protein macromolecules . The protein exclusio... | RAM MMIPs were prepared as M SPE material for selective extraction of trace TCs. RAM MMIPs possess satisfactory protein exclusion properties. The method extract TCs directly from untreated milk and eggs successfully. |
S0021967319311148 | Ion exchange chromatography is extensively used in the purification of biological compounds . Reliable mathematical models describing this chromatographic technique are available and can be used to improve the performance of this separation step . However the use of synthetic mixtures for model development hampers the ... | Describe an approach to model protein purification from real cell extracts. Simulate and test models for ion exchange chromatography using software EMSO. Approach applied to the purification of an untagged recombinant PspA. Model simulations enhance PspA purity in 34 . Approach can be extended to any kind of complex pr... |
S002196731931115X | Being performance enhancing hormones endogenous anabolic androgenic steroids are banned from most competitive sports by the World Anti doping Agency . In anti doping control laboratories routine assays are mainly performed on urine samples of athletes in and out of competitions . Serum constitutes a promising alternati... | A UHPLC HRMS method was developed for simultaneous EAAS analysis in human serum. A solid phase extraction method was developed for EAAS extraction from serum. The method was validated for application to doping routine analysis. The method was applied to estimate baseline levels of EAAS in healthy subjects. |
S0021967319311161 | Application of the superficially porous particles grafted with chiral selectors can substantially improve resolution in chromatographic techniques . In this work we carried out a deeper study on supercritical fluid chromatography systems with 2.7m SPPs bonded with teicoplanin and vancomycin . Fast separations of the ma... | TeicoShell and VancoShell columns with superficially porous particles in SFC. Effect of co solvents and additives on retention and enantioseparation. Complementary behavior of TeicoShell and VancoShell columns. Enantioselective separation of five groups of biologically active analytes. |
S0021967319311173 | Diffusion inside pores is the rate limiting step in many preparative chromatographic separations and a key parameter for process design in weak interaction aqueous chromatographic separations employed in food and bio processing . This work aims at relating diffusion inside porous networks to properties of stationary ph... | Intraparticle diffusivity measured for nine stationary phases and eight molecules. Stationary phases were series of Dowex Sephadex and Toyopearl. Measured pore characteristics particle porosity pore size distribution and tortuosity. Calculations with parallel pore model and relation of Mackie and Meares. Improved predi... |
S0021967319311203 | Conventional gas chromatography mass spectrometry takes 2040min per sample which is undesirably slow in any application if speed can be increased while still meeting analytical needs . In this study we achieved reasonably good separations with full analysis cycle times of less than 1min by combining for the first time ... | We report the novel and useful LTM LPGC MS technique for the first time. A new working instrument for real world application was developed. LTM LPGC MS concepts features and trade offs are described and evaluated. Example applications with 1min analysis cycle times are demonstrated. Comparison of LTM LPGC MS is made wi... |
S0021967319311227 | An ultrasensitive microchip electrophoresis chemiluminescence assay platform based on separation assisted cascade signal amplification was developed for detection of trace biomolecules . In this work the aptamer was used as a target probe to bindtargetmolecule and triggering cascade signal amplification reaction . The ... | An ultrasensitive microchip electrophoresis chemiluminescence assay platform was developed. The assay was based on separation assisted cascade signal amplification to enhance sensitivity. This protocol provides a new platform for the detection of trace biomolecules. The method showed very high sensitivity the detection... |
S0021967319311239 | A novel miniaturized sample preparation device with braid type extraction medium was successfully developed . Introducing a set of bundles of fine synthetic filaments as the materials of the braid type extraction medium and also the application of an appropriate tension during the braiding process the outer diameter of... | Miniaturized sample preparation with braid type extraction medium was developed. The extraction capillary was prepared using the braid with a metal wire inside. Applying low voltages to the metal wire a heat assisted desorption was made. |
S0021967319311240 | The ferrofluid phase was prepared according to mixing magnetic nanoparticle and the hydrophobic deep eutectic solvent as a green microextraction solvent . This new composite was applied for vortex assisted dispersive liquidliquid microextraction of doxycycline residual extraction and determined through high performance... | Application of hydrophobic deep eutectic solvent as the carrier for ferrofluid. Pre concentration and determination of doxycycline in biological samples. Application of VA HDES ferrofluid DLLME based on experimental design optimization. |
S0021967319311252 | Thermodynamic modeling of GCGC separations provides a tool for rapid method evaluation and optimization . Separations of 95 hydrocarbons on two cryogenically modulated GCGC systems are modeled displaying average second dimension retention time modeling absolute errors of 0.17s and 0.12s respectively and generating mode... | A web based GCGC modeling application is presented. Hydrocarbon separations can be modeled with full control of system parameters. Modeling accuracy is shown across two GCGC systems. GCGC HRT hydrocarbon temporal distribution plots are replicated. |
S0021967319311264 | S9570 Fe a modified chelating resin containing sulphonated monophosphonic acid bifunctional groups was used for the fluoride removal from aqueous phase for the first time . The results specified that S9570 Fe exhibited better adsorption towards the fluoride ions as compared to the other commonly used chelating resins h... | A novel chelating resin with bifunctional groups was applied for fluoride removal. Resin exhibited better adsorption to fluoride compared with commonly used resins. Adsorption mechanism of the present resin for fluoride was speculated. |
S0021967319311288 | Short peptides namely di tri and tetra peptides have been proven to play an important diagnostic role in several diseases . Therefore the development of an analytical approach for their detection and identification is nowadays an important research goal . This paper describes an analytical procedure able to overcome th... | Development of an efficient clean up strategy for short peptides in plasma. Comparison of 4 different clean up protocols advantages and disadvantages . Untargeted peptidomic approach for short peptide identification in plasma. Identification of 91 short peptides the largest number never identified before. Development o... |
S002196731931129X | In recent years supercritical fluid chromatography has become a powerful tool in modern analytical chemistry and the diversity of stationary phases in SFC promotes phenyl type phases to confront with a significant resurgence of interest . In this paper a series of phenyl type stationary phases with different substitute... | Using LSER for evaluation of phenyl type phases to extend their applications in SFC. Electron withdrawing or donating groups causing different. and. coefficients. angles and. plot showed different selectivity among phenyl type phases. Construction of two systems with 63.49 orthogonality based on 25 phenolic compounds. ... |
S0021967319311306 | Polychlorinated dibenzo p dioxins and furans offer a complex separation challenge due to their chemical similarity and 5020 possible congeners including the Br Cl congeners . Not only are these compounds difficult to separate but they are also difficult to identify . Expensive reference materials are needed for convent... | Characterization of 9 modern and popular GC columns for dioxin analysis. Full elution orders for all 136 tetra octa chlorinated dioxins and furans. Retention index database for 136 chlorinated dioxins and 32 mixed halogenated dioxins. Selectivity and orthogonality comparisons for 8 modern GC columns for dioxin analysis... |
S002196731931132X | Byproducts from artichoke represent the majority of the mass collected from the plant and constitute an interesting source of bioactive compounds such as inositols and caffeoylquinic acids . In this work a microwave assisted extraction methodology was developed for the simultaneous extraction of these compounds from ar... | Inositols and caffeoylquinic acids from artichoke were analyzed by GCMS. Regarding derivatization best results were achieved with HMDS and BSTFA 1 TMCS. A MAE method was optimized for extraction of these bioactives from artichoke bracts. Optimal conditions were applied to different artichoke byproducts. Receptacles wer... |
S0021967319311331 | Profiling the spatial distributions and dynamic changes of metabolites in plant tissue is critical to elucidate the complex metabolic regulation during plant growth development and responses to abiotic or biotic stresses . In this study we developed a high coverage MALDI MS imaging method to visualize the spatial locat... | A high coverage MALDI MSI method was developed for plant tissue analysis. BNDM was optimized as a new matrix for MALDI MSI of. Acetone washing improves the sensitivity of MALDI MSI. Spatial feature and dynamics of metabolites in. were imaged. |
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