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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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A
T
A
T
A
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T
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G
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C
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C
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G
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31,377
T
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C
A
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G
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31,378
A
T
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A
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C
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0
31,379
G
C
T
T
T
A
G
A
T
C
A
A
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C
A
T
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T
G
C
C
T
C
T
T
T
C
C
A
C
C
A
T
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G
C
C
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T
T
C
A
G
A
T
C
A
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T
C
T
T
A
A
A
A
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T
T
T
C
C
T
C
T
C
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0
31,380
A
A
T
G
A
T
A
A
T
G
A
A
A
C
A
G
T
C
A
C
A
A
A
G
C
G
A
A
A
A
A
G
C
G
C
A
T
G
T
G
G
A
G
G
A
T
C
C
C
C
T
G
C
T
T
C
G
T
G
G
T
T
T
T
T
T
0.103718
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0
31,381
A
A
C
A
T
C
T
G
G
C
T
C
A
C
A
G
T
T
G
C
A
A
C
A
G
G
A
A
A
T
G
T
T
G
C
T
G
A
T
A
G
A
A
G
C
A
T
T
T
T
C
C
T
C
T
G
T
T
C
C
G
T
T
T
T
C
0.080235
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0
31,382
T
G
A
G
G
G
T
G
A
C
T
C
T
G
A
T
G
G
A
G
A
G
G
A
G
C
C
T
T
G
T
T
T
C
T
C
T
A
G
T
G
C
T
C
C
T
C
C
A
A
A
T
G
A
A
T
C
T
G
C
A
G
T
T
C
A
0.052838
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0.017613
0.035225
0.021526
0.041096
0.011742
0.015656
0.060665
0
31,383
C
T
C
C
A
C
G
T
A
G
C
G
C
T
C
C
A
C
C
T
T
G
A
T
C
T
G
C
A
T
C
G
C
G
C
C
C
A
G
A
G
C
A
C
C
G
A
A
G
C
C
G
T
C
C
T
C
G
C
C
C
G
C
C
T
G
0.011742
0.023483
0.031311
0
0.027397
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0
0.005871
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0.068493
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0.09002
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0.074364
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0.011742
0
31,384
C
A
T
C
T
G
T
C
T
C
T
G
C
C
T
T
C
T
C
G
G
C
A
G
C
A
T
C
T
T
C
C
C
G
G
T
T
A
G
A
C
C
T
C
A
T
C
T
T
C
T
T
A
T
G
G
A
C
C
C
G
C
C
T
T
T
0.068493
0.039139
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0.029354
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0.021526
0.02544
0.021526
0.029354
0.019569
0.043053
0.039139
0
31,385
T
T
T
C
C
C
A
T
T
C
A
T
G
T
T
C
A
G
T
C
C
A
T
G
T
G
T
C
C
T
T
A
C
A
A
G
T
G
A
A
G
C
A
A
G
T
T
T
C
T
T
C
T
A
G
G
C
A
G
C
A
T
A
T
A
A
0.046967
0.029354
0.043053
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0
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0.033268
0
31,386
G
T
T
A
C
C
A
T
G
G
T
T
T
G
G
G
A
C
C
A
C
A
G
A
G
A
T
C
A
C
G
T
C
A
A
C
A
A
C
A
G
C
C
T
G
T
T
C
C
A
A
A
T
A
G
T
G
A
T
G
C
T
G
T
C
G
0.088063
0.043053
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0.066536
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0.027397
0.048924
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0.031311
0.013699
0.027397
0.033268
0
31,387
T
A
G
A
T
T
T
C
T
T
C
A
T
A
C
C
T
G
G
A
G
A
T
T
G
T
C
T
T
T
T
T
C
T
G
C
A
T
C
T
T
C
T
T
T
T
G
G
A
T
T
C
A
C
T
C
T
C
T
T
G
G
A
G
A
T
0.078278
0.029354
0.052838
0.072407
0.033268
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0.009785
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0
0.009785
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0.058708
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0.027397
0.023483
0.046967
0.039139
0
31,388
A
G
A
A
A
A
C
G
C
A
G
A
G
G
C
A
G
G
A
A
A
A
G
T
G
C
T
A
A
T
A
A
T
A
C
A
C
C
A
G
A
A
A
A
T
A
G
T
C
C
C
A
A
C
T
T
C
C
C
T
A
A
C
T
T
A
0.082192
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0.046967
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0.052838
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0.011742
0
0.011742
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0.027397
0.033268
0.060665
0.023483
0.029354
0.017613
0.033268
0.021526
0.029354
0.031311
0
31,389
T
G
T
G
C
T
T
C
C
G
G
C
C
T
A
G
G
A
C
C
A
G
C
A
G
T
C
G
C
A
G
A
T
T
C
C
G
T
T
T
G
G
C
T
A
G
T
T
G
A
G
A
G
A
C
G
A
C
A
T
T
C
A
A
G
C
0.088063
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0.019569
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0.039139
0.033268
0
31,390
A
G
C
T
T
C
C
T
T
T
G
G
A
G
G
T
G
G
C
T
A
T
G
G
C
A
G
G
T
C
T
T
C
G
G
A
G
A
G
G
T
A
A
G
T
C
C
C
T
C
A
C
T
C
A
G
A
C
T
T
G
T
T
G
C
T
0.062622
0.017613
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0.005871
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0.035225
0
31,391
C
A
C
A
T
C
A
G
C
A
G
A
G
G
A
C
G
T
A
A
C
C
C
C
A
G
T
G
T
C
G
G
T
T
C
C
A
A
A
G
C
C
A
A
A
A
T
C
T
A
T
A
G
G
A
A
G
A
A
G
A
A
A
T
G
C
0.068493
0.029354
0.050881
0.064579
0.039139
0.007828
0.007828
0.039139
0.054795
0.033268
0.013699
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0.039139
0.041096
0.033268
0.017613
0.037182
0.02544
0.017613
0.005871
0.005871
0
0.023483
0.029354
0.048924
0.011742
0.021526
0.011742
0.02544
0.037182
0.062622
0.043053
0
31,392
A
A
A
G
A
A
G
A
T
C
A
T
C
A
T
C
T
C
C
T
T
C
A
A
G
G
T
C
A
A
T
G
T
A
C
T
G
G
A
T
T
T
G
T
T
C
A
A
A
A
G
C
T
G
A
A
T
C
T
G
C
A
A
G
T
C
0.062622
0.033268
0.050881
0.039139
0.027397
0.027397
0.003914
0.04501
0.056751
0.023483
0.033268
0.035225
0.043053
0.035225
0.035225
0.02544
0.056751
0.033268
0.013699
0.001957
0.001957
0
0.02544
0.02544
0.066536
0.027397
0.02544
0.005871
0.035225
0.015656
0.021526
0.066536
0
31,393
A
A
G
C
T
G
G
T
C
C
C
C
A
C
T
C
G
T
C
T
C
C
T
C
C
C
C
T
C
C
T
C
C
A
T
C
T
A
T
A
A
A
A
T
A
A
A
T
G
T
A
C
T
T
T
G
G
T
C
C
T
A
A
T
A
T
0.054795
0.02544
0.048924
0.043053
0.039139
0.027397
0.007828
0.033268
0.046967
0.023483
0.043053
0.041096
0.023483
0.04501
0.035225
0.02544
0.033268
0.04501
0.027397
0
0.005871
0.005871
0.017613
0.046967
0.039139
0.029354
0.021526
0.007828
0.054795
0.027397
0.043053
0.031311
0
31,394
C
T
C
C
A
G
G
G
C
T
C
C
C
T
T
C
T
C
C
A
A
C
C
C
G
T
T
C
A
C
C
G
C
G
T
G
C
G
G
G
G
C
G
G
C
G
G
C
G
G
G
G
A
A
G
T
T
G
T
T
G
C
G
G
C
G
0.009785
0.011742
0.039139
0.001957
0.013699
0.031311
0.017613
0.013699
0.027397
0.054795
0.066536
0
0.011742
0.005871
0.023483
0.029354
0.052838
0.058708
0.088063
0.043053
0.02544
0.058708
0.007828
0.064579
0.02544
0.027397
0.017613
0.084149
0.054795
0.007828
0.003914
0.021526
0
31,395
A
C
G
C
C
G
G
C
T
C
C
A
G
G
G
C
T
G
A
G
G
G
C
T
C
G
A
T
G
G
G
G
C
T
C
C
T
G
G
T
G
G
T
C
A
C
C
G
A
G
G
C
G
C
T
G
C
C
T
A
G
A
G
G
C
T
0.048924
0.035225
0.02544
0.017613
0.033268
0.037182
0.019569
0.02544
0.021526
0.04501
0.043053
0.021526
0.007828
0.02544
0.039139
0.037182
0.046967
0.04501
0.060665
0.033268
0.013699
0.015656
0.021526
0.041096
0.021526
0.021526
0.046967
0.052838
0.033268
0.021526
0.017613
0.023483
0
31,396
C
A
T
G
G
C
G
C
C
C
G
C
C
G
A
G
C
C
C
C
C
C
G
G
C
A
T
G
C
C
G
G
C
T
A
C
T
G
C
G
C
C
G
G
G
A
C
T
C
A
G
G
C
C
G
G
C
C
C
C
T
A
G
G
C
T
0
0.027397
0.009785
0.001957
0.017613
0.027397
0.029354
0.021526
0.005871
0.033268
0.037182
0.001957
0
0.074364
0.013699
0.019569
0.033268
0.050881
0.068493
0.086106
0.009785
0.078278
0.021526
0.033268
0.021526
0.031311
0.035225
0.11546
0.031311
0.019569
0.003914
0.039139
0
31,397
G
C
G
G
C
C
T
C
C
C
G
C
G
C
G
T
C
G
C
T
G
G
G
C
G
G
C
C
A
G
C
T
C
T
C
C
T
G
T
T
C
T
C
C
C
T
G
G
G
C
T
C
C
T
A
A
C
C
C
C
G
C
C
G
C
G
0.019569
0.019569
0.027397
0.013699
0.019569
0.015656
0.021526
0.017613
0.039139
0.052838
0.050881
0.005871
0.017613
0.029354
0.021526
0.013699
0.046967
0.050881
0.046967
0.041096
0.02544
0.068493
0.011742
0.074364
0.02544
0.019569
0.029354
0.068493
0.058708
0.021526
0.011742
0.013699
0
31,398
G
G
C
G
G
C
C
T
C
C
C
G
C
G
C
G
T
C
G
C
T
G
G
G
C
G
G
C
C
A
G
C
T
C
T
C
C
T
G
T
T
C
T
C
C
C
T
G
G
G
C
T
C
C
T
A
A
C
C
C
C
G
C
C
G
A
0.021526
0.019569
0.027397
0.013699
0.019569
0.015656
0.021526
0.017613
0.039139
0.052838
0.050881
0.005871
0.017613
0.029354
0.021526
0.013699
0.046967
0.048924
0.046967
0.041096
0.02544
0.068493
0.011742
0.074364
0.02544
0.019569
0.029354
0.068493
0.058708
0.021526
0.011742
0.013699
0
31,399
T
G
T
G
G
A
A
G
T
G
C
T
T
A
A
G
A
A
G
G
C
T
T
T
G
G
A
T
G
C
C
A
T
T
T
C
T
C
A
T
T
C
T
G
A
T
A
A
A
G
G
A
C
C
A
G
A
T
G
C
C
A
C
A
G
G
0.050881
0.029354
0.058708
0.037182
0.050881
0.033268
0.005871
0.031311
0.050881
0.033268
0.037182
0.043053
0.015656
0.029354
0.039139
0.035225
0.050881
0.037182
0.02544
0.003914
0.001957
0
0.019569
0.023483
0.041096
0.02544
0.039139
0.021526
0.02544
0.031311
0.04501
0.027397
0
31,400
T
A
C
A
G
C
T
A
T
C
A
G
C
A
T
G
G
A
C
A
A
A
A
A
T
A
G
T
T
A
T
A
C
A
G
C
A
T
T
T
T
A
T
A
A
C
A
G
A
G
C
A
T
T
A
T
G
T
T
A
C
A
C
C
A
T
0.11546
0.033268
0.04501
0.099804
0.052838
0.009785
0
0.027397
0.039139
0.027397
0.013699
0.066536
0.027397
0.050881
0.031311
0.019569
0.021526
0.015656
0.001957
0
0
0
0.027397
0.013699
0.043053
0.009785
0.017613
0.001957
0.017613
0.027397
0.105675
0.037182
0
31,401
A
A
A
G
T
A
A
G
C
C
A
G
C
G
A
G
T
A
C
T
T
G
G
G
G
T
T
T
A
G
A
G
T
A
A
T
T
G
C
A
T
C
T
T
G
G
T
A
G
T
C
T
T
T
C
A
T
T
G
C
A
T
T
C
T
A
0.082192
0.027397
0.037182
0.084149
0.031311
0.013699
0.003914
0.041096
0.039139
0.021526
0.017613
0.07045
0.023483
0.052838
0.031311
0.015656
0.031311
0.031311
0.019569
0
0.003914
0.003914
0.027397
0.023483
0.041096
0.007828
0.033268
0.015656
0.017613
0.039139
0.076321
0.035225
0
31,402
T
T
C
C
C
C
A
A
A
C
A
A
G
G
C
T
G
A
A
G
C
T
G
T
G
C
T
G
C
A
T
A
T
T
C
T
T
A
C
C
T
A
G
C
C
T
A
G
G
A
A
G
T
C
A
T
A
A
A
A
C
A
T
C
A
C
0.09002
0.027397
0.048924
0.050881
0.037182
0.013699
0
0.041096
0.048924
0.035225
0.033268
0.029354
0.035225
0.041096
0.035225
0.02544
0.048924
0.023483
0.009785
0
0
0
0.035225
0.02544
0.052838
0.017613
0.033268
0.017613
0.02544
0.021526
0.039139
0.056751
0
31,403
A
G
C
A
C
T
G
A
C
A
T
T
C
T
C
T
T
T
C
C
C
A
G
G
A
G
A
A
A
G
G
G
T
T
T
T
A
C
A
T
T
C
T
T
T
A
T
C
T
G
G
C
T
C
A
A
T
T
T
C
A
A
A
T
T
A
0.064579
0.035225
0.04501
0.041096
0.029354
0.02544
0
0.033268
0.046967
0.048924
0.050881
0.005871
0.017613
0.033268
0.033268
0.011742
0.062622
0.043053
0.027397
0
0.003914
0
0.019569
0.052838
0.060665
0.019569
0.015656
0.021526
0.048924
0.021526
0.027397
0.052838
0
31,404
C
T
T
A
T
C
C
T
T
T
G
A
T
C
C
T
T
T
T
G
T
A
T
C
T
C
T
A
C
T
A
C
T
A
C
C
A
C
C
T
T
T
T
G
A
A
G
A
T
T
T
G
T
G
A
C
T
T
C
T
T
T
C
T
A
C
0.056751
0.011742
0.072407
0.021526
0.021526
0.013699
0.003914
0.062622
0.07045
0.037182
0.033268
0.021526
0.039139
0.011742
0.027397
0.019569
0.052838
0.023483
0.011742
0.015656
0.013699
0.005871
0.050881
0.027397
0.058708
0.023483
0.041096
0.017613
0.041096
0.046967
0.021526
0.023483
0
31,405
G
A
T
T
T
T
T
C
A
T
C
T
T
T
A
T
C
T
T
C
T
T
C
A
T
A
A
G
G
A
T
A
T
A
T
A
T
T
T
T
C
A
C
C
A
T
A
A
T
C
A
C
C
G
T
T
T
A
A
T
T
C
A
C
T
C
0.07045
0.029354
0.060665
0.04501
0.041096
0.013699
0.003914
0.048924
0.046967
0.021526
0.019569
0.066536
0.041096
0.046967
0.041096
0.02544
0.031311
0.029354
0.007828
0.003914
0.003914
0
0.023483
0.021526
0.060665
0.023483
0.013699
0.003914
0.035225
0.02544
0.033268
0.060665
0
31,406
A
A
A
G
C
A
A
T
C
C
A
C
C
A
C
T
A
C
A
A
G
A
T
T
T
T
C
C
C
A
A
T
T
C
C
A
T
A
T
C
A
T
C
T
G
A
T
A
A
A
G
A
A
G
C
C
A
C
A
G
T
T
C
C
A
C
0.072407
0.037182
0.043053
0.062622
0.039139
0.023483
0
0.02544
0.058708
0.027397
0.02544
0.033268
0.04501
0.043053
0.050881
0.02544
0.037182
0.041096
0.011742
0
0
0
0.031311
0.02544
0.058708
0.015656
0.019569
0.015656
0.029354
0.011742
0.033268
0.056751
0
31,407
G
T
C
T
A
C
T
G
A
T
G
G
T
T
T
C
G
A
A
T
T
T
T
C
A
T
C
A
C
T
A
T
C
T
T
T
A
G
A
A
G
A
T
G
A
G
G
G
T
T
C
A
A
A
A
T
A
T
A
C
T
T
C
T
T
G
0.097847
0.037182
0.043053
0.066536
0.037182
0.023483
0.005871
0.027397
0.066536
0.011742
0.031311
0.072407
0.035225
0.031311
0.029354
0.015656
0.029354
0.013699
0.011742
0.001957
0.011742
0
0.041096
0.023483
0.058708
0.015656
0.015656
0.007828
0.015656
0.02544
0.056751
0.039139
0
31,408
G
A
G
C
A
G
C
T
T
T
G
G
C
G
C
T
A
T
G
G
A
G
G
A
G
C
C
C
G
G
G
G
T
T
A
C
C
C
C
T
C
A
A
C
C
G
T
A
T
T
T
G
G
G
G
C
T
G
C
T
C
C
T
G
G
C
0.015656
0.023483
0.019569
0.005871
0.027397
0.041096
0.021526
0.019569
0.013699
0.050881
0.050881
0.009785
0.009785
0.009785
0.017613
0.035225
0.048924
0.037182
0.084149
0.072407
0.027397
0.043053
0.015656
0.050881
0.015656
0.029354
0.031311
0.07045
0.050881
0.021526
0.015656
0.013699
0
31,409
A
T
G
T
G
T
G
T
T
T
T
C
T
G
A
C
T
G
C
A
A
A
G
A
T
G
C
T
T
G
T
T
C
A
G
T
C
T
G
A
A
G
A
T
T
T
T
T
A
A
T
A
T
G
C
T
C
T
A
T
A
T
A
A
A
G
0.119374
0.041096
0.039139
0.097847
0.04501
0.009785
0
0.037182
0.041096
0.019569
0.011742
0.088063
0.027397
0.041096
0.037182
0.015656
0.02544
0.007828
0.001957
0
0
0
0.027397
0.017613
0.046967
0.009785
0.015656
0
0.009785
0.021526
0.093933
0.050881
0
31,410
T
C
T
T
G
C
A
T
C
C
A
C
T
G
G
A
A
A
C
A
A
T
G
G
A
C
C
T
C
T
G
A
T
T
G
G
A
G
C
A
A
G
A
G
G
T
G
G
A
G
G
A
A
C
A
A
A
G
C
C
A
G
G
G
C
C
0.093933
0.021526
0.039139
0.060665
0.035225
0.017613
0
0.02544
0.048924
0.037182
0.035225
0.021526
0.033268
0.041096
0.031311
0.027397
0.039139
0.046967
0.021526
0.003914
0.007828
0
0.023483
0.04501
0.04501
0.013699
0.02544
0.019569
0.048924
0.015656
0.043053
0.031311
0
31,411
C
T
T
T
A
C
C
A
G
C
T
G
A
G
G
G
C
G
C
C
C
T
T
G
A
A
G
A
G
G
C
C
C
C
A
G
C
T
A
A
A
G
T
A
G
A
G
C
C
T
C
C
C
A
C
T
G
T
T
G
A
A
G
A
G
T
0.033268
0.011742
0.054795
0.029354
0.011742
0.019569
0.001957
0.027397
0.07045
0.080235
0.062622
0.003914
0.007828
0.013699
0.013699
0.011742
0.082192
0.027397
0.027397
0.007828
0.009785
0.003914
0.027397
0.076321
0.07045
0.017613
0.029354
0.043053
0.039139
0.019569
0.011742
0.052838
0
31,412
T
C
C
A
C
C
A
G
C
T
G
A
A
A
A
G
T
C
T
C
C
T
T
C
A
G
T
A
G
A
G
C
T
T
C
T
T
G
G
T
G
A
A
A
T
T
C
G
G
T
C
T
C
C
C
T
C
A
G
C
A
C
A
A
A
C
0.031311
0.017613
0.054795
0.029354
0.013699
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0.027397
0.041096
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0
31,413
T
T
C
A
T
T
T
A
C
T
C
A
G
G
A
G
A
C
T
A
A
A
A
A
A
G
G
T
C
C
C
C
C
G
G
T
A
C
T
T
T
T
A
G
A
A
G
A
T
G
A
G
C
T
T
A
G
G
G
A
A
G
A
A
G
T
0.074364
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0
31,414
A
A
A
T
C
G
T
C
G
G
G
A
A
A
G
A
T
T
T
T
T
G
C
T
A
G
T
G
A
A
C
A
C
C
C
T
G
A
A
T
T
T
C
A
A
C
C
A
G
C
A
A
C
A
A
A
C
A
G
C
A
A
T
G
A
A
0.084149
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0
31,415
T
C
C
A
A
G
G
C
G
A
A
T
A
A
C
C
A
G
T
A
A
A
T
G
C
A
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G
A
C
T
T
C
A
A
G
T
G
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G
C
C
A
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C
A
C
C
A
C
T
T
T
G
A
A
G
T
T
A
G
A
A
T
G
0.037182
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0
31,416
G
T
C
A
C
T
T
T
T
A
T
T
T
T
C
A
G
G
G
T
C
T
A
C
A
C
A
A
G
C
T
T
C
C
A
C
C
A
G
G
A
A
G
G
A
A
A
T
A
T
G
G
T
G
C
A
G
T
A
A
G
A
G
A
G
T
0.093933
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0.058708
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0
31,417
A
T
T
T
T
C
A
A
C
A
G
T
G
G
A
A
T
T
T
C
T
G
T
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T
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T
A
C
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A
A
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T
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A
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A
C
C
G
T
G
A
T
T
A
T
T
T
T
C
T
T
T
T
T
A
0.111546
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0
31,418
A
T
A
C
A
T
T
A
C
C
T
G
G
T
A
T
T
T
A
C
T
T
A
C
T
C
T
G
T
T
T
A
T
A
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G
A
A
A
T
C
T
G
C
G
C
T
T
T
T
T
G
A
C
A
G
C
A
T
G
A
A
G
T
G
C
0.131115
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0.027397
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0.07045
0.039139
0
31,419
C
G
G
A
C
A
T
C
T
A
G
C
A
C
T
A
A
T
G
T
T
T
C
C
C
A
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G
C
C
C
T
C
T
G
C
C
T
C
T
G
C
A
A
A
A
A
G
A
G
G
A
G
C
T
C
A
T
G
G
T
C
C
A
C
G
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0
31,420
T
G
G
C
T
C
T
T
T
G
A
G
C
A
G
T
A
T
C
T
G
T
T
T
G
G
T
T
T
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C
T
C
G
T
G
C
A
T
C
A
T
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T
T
T
C
A
T
T
G
A
T
T
T
C
C
T
T
A
T
G
T
C
A
T
0.113503
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0.037182
0
31,421
T
C
C
A
G
C
T
T
C
A
T
T
T
A
T
G
A
T
G
C
T
A
C
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A
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C
C
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A
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G
T
T
T
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C
A
T
T
G
G
A
A
A
G
A
C
T
C
T
T
C
A
C
A
G
A
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0
31,422
G
C
A
A
T
G
A
G
T
G
A
T
G
C
A
G
A
C
A
A
A
G
T
C
T
C
A
G
A
C
T
T
T
G
T
A
G
A
G
C
T
T
C
C
A
T
T
C
T
A
T
G
G
A
G
A
A
A
C
C
A
C
A
T
C
C
0.076321
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0.041096
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0
31,423
G
G
T
A
C
T
T
T
C
C
A
G
G
G
G
T
A
G
T
G
T
T
T
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G
G
A
A
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T
C
A
A
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A
T
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T
T
T
C
T
T
T
T
A
T
C
T
C
C
A
A
T
A
G
T
G
T
T
A
C
A
0.084149
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0.064579
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0
31,424
T
A
T
A
A
T
T
C
T
A
C
A
A
C
T
T
T
T
A
T
T
T
A
T
T
C
A
G
G
C
C
A
T
T
T
C
C
A
G
C
A
G
T
T
T
A
A
A
A
G
G
T
T
T
C
C
T
T
T
C
A
G
C
T
A
A
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0
31,425
C
C
T
T
G
T
G
T
C
A
T
T
C
T
A
C
A
C
T
C
C
A
G
A
A
G
T
C
A
C
T
T
C
G
G
A
G
T
T
T
G
G
A
C
C
T
C
A
G
C
A
A
G
A
A
C
A
A
A
A
T
C
A
A
G
T
0.082192
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0.041096
0.043053
0
31,426
T
C
T
C
T
T
C
A
G
T
T
A
T
T
A
C
T
G
A
C
T
C
G
T
T
T
A
A
G
T
T
A
T
C
T
T
T
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C
C
T
C
A
T
T
T
G
A
A
C
A
A
G
T
A
G
C
A
C
T
T
T
T
T
C
0.097847
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0
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0
0.017613
0.02544
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0.054795
0
31,427
T
C
C
G
G
G
T
G
C
A
C
G
A
A
C
C
G
C
A
C
T
T
C
C
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C
C
C
C
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C
G
C
T
C
A
C
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C
T
C
T
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G
C
G
C
G
G
T
G
A
T
C
T
C
C
G
C
C
T
C
G
T
A
G
0.005871
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0.017613
0.031311
0.033268
0.082192
0.052838
0.017613
0
0.017613
0
31,428
T
A
T
G
T
C
T
T
C
A
A
C
T
G
G
T
T
T
A
T
C
T
G
C
T
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C
C
A
A
G
C
T
T
G
G
T
T
T
T
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T
T
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C
T
C
T
T
T
T
C
T
G
A
A
T
G
A
T
A
T
A
T
C
A
0.078278
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0.058708
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0.029354
0.015656
0.027397
0.023483
0.037182
0.048924
0
31,429
C
C
T
G
G
A
A
A
C
G
C
C
C
G
A
G
T
T
T
T
C
T
G
G
C
G
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C
G
G
G
G
C
C
C
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C
G
C
G
C
T
G
A
G
C
C
G
G
C
G
G
T
C
G
G
T
G
C
T
G
G
A
G
C
A
0.02544
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0.02544
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0.019569
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0.039139
0.023483
0.013699
0.021526
0
31,430
T
A
T
A
T
A
T
A
C
A
C
A
T
A
T
A
T
A
T
A
C
A
C
A
C
A
C
A
C
A
C
A
C
A
T
T
T
T
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T
G
T
G
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C
A
G
T
T
T
T
C
A
A
T
A
T
A
T
A
G
T
T
A
A
T
0.105675
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0.027397
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0.019569
0.02544
0.056751
0.035225
0
31,431
G
C
T
T
G
A
A
T
A
T
T
T
T
T
T
A
T
A
T
A
T
A
T
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C
A
C
A
T
A
T
A
T
A
T
A
C
A
C
A
C
A
C
A
C
A
C
A
C
A
T
T
T
T
A
T
G
T
G
T
0.097847
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0.048924
0.054795
0.046967
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0.009785
0.027397
0.011742
0.023483
0.023483
0.048924
0.035225
0
31,432
G
G
T
T
T
G
G
C
T
T
G
A
A
T
A
T
T
T
T
T
T
A
T
A
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A
C
A
C
A
C
A
C
A
T
T
T
C
0.093933
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0.050881
0.052838
0.046967
0.017613
0.009785
0.027397
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0.027397
0.011742
0.023483
0.023483
0.046967
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0
31,433
T
C
A
T
A
C
T
T
C
C
T
C
A
A
T
T
T
A
T
T
T
A
A
A
G
C
T
A
C
A
A
G
C
G
C
T
A
C
C
A
G
T
C
A
A
T
A
G
C
A
A
A
G
C
A
A
A
G
C
A
A
C
G
C
C
T
0.080235
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0
31,434
G
T
A
C
T
G
T
T
T
T
G
T
G
T
G
T
C
T
A
G
A
T
C
A
A
A
T
G
A
T
G
C
C
G
T
T
T
G
G
A
A
A
A
A
T
T
T
C
C
C
A
G
C
A
G
T
T
G
T
G
T
G
G
C
G
T
0.086106
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0.029354
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0
31,435
G
C
T
T
C
C
T
G
A
T
G
C
C
A
C
A
C
A
G
G
G
G
C
C
A
G
G
G
T
T
T
C
C
A
G
C
C
T
G
C
A
T
G
A
G
C
A
C
A
G
G
T
C
T
C
A
A
C
A
A
G
G
T
A
C
T
0.062622
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0.027397
0
0.029354
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0.060665
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0.041096
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0
0
0
0.02544
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0.029354
0.023483
0.029354
0.027397
0.050881
0.02544
0.021526
0.046967
0
31,436
T
C
T
T
T
T
A
G
G
G
C
T
G
T
C
T
C
C
A
C
A
T
G
G
A
C
C
C
T
A
C
T
C
A
A
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G
G
C
T
G
A
C
A
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G
T
G
A
A
C
A
G
C
T
G
T
T
G
C
A
T
C
A
C
G
0.09002
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0.054795
0.052838
0.041096
0.021526
0
0.033268
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0.027397
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0
0.029354
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0.066536
0.015656
0.02544
0.017613
0.035225
0.017613
0.037182
0.043053
0
31,437
T
T
A
A
A
C
A
G
G
T
C
A
G
T
C
A
G
A
T
G
A
A
T
T
C
C
C
T
T
G
A
A
C
A
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G
A
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T
T
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G
A
A
A
C
A
A
T
T
C
A
T
T
T
G
G
A
A
A
A
T
G
A
A
G
0.088063
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0.054795
0.07045
0.052838
0.011742
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0.02544
0.02544
0.02544
0.019569
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0
0.001957
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0.060665
0.019569
0.015656
0.019569
0.023483
0.023483
0.052838
0.052838
0
31,438
T
G
C
C
T
T
G
A
A
G
T
C
T
C
A
A
A
A
C
C
A
G
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A
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A
T
T
C
A
G
C
C
C
C
T
C
A
T
T
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C
T
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T
T
T
T
G
A
C
C
T
C
A
T
C
G
T
A
A
C
T
C
T
0.058708
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0.048924
0.029354
0.035225
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0.046967
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0.029354
0.056751
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0.017613
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0.013699
0.054795
0.066536
0.017613
0.023483
0.017613
0.039139
0.019569
0.015656
0.062622
0
31,439
C
T
A
C
T
T
G
C
T
T
C
G
T
T
C
G
G
T
T
T
T
G
C
T
G
T
A
A
A
A
A
C
T
G
C
T
C
T
G
T
T
T
G
T
T
C
C
G
C
A
G
T
A
T
T
T
C
C
A
A
A
A
A
A
C
G
0.056751
0.033268
0.04501
0.02544
0.037182
0.019569
0.007828
0.033268
0.050881
0.058708
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0.027397
0.02544
0.013699
0.072407
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0.023483
0.009785
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0.02544
0.050881
0.058708
0.031311
0.02544
0.017613
0.052838
0.019569
0.019569
0.048924
0
31,440
C
A
G
G
G
T
T
A
G
T
A
A
T
G
T
C
T
T
C
T
T
G
T
T
T
G
G
A
T
G
A
G
C
C
A
G
C
T
A
C
T
G
A
G
T
T
T
T
T
T
G
G
A
A
A
T
A
C
T
G
C
G
G
A
A
G
0.056751
0.033268
0.043053
0.021526
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0.007828
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0.054795
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0.060665
0.052838
0.029354
0.029354
0.019569
0.052838
0.019569
0.013699
0.04501
0
31,441
C
C
A
T
G
A
C
T
T
T
T
T
T
T
T
C
C
T
C
T
C
T
T
T
T
T
C
A
G
A
A
A
T
C
T
G
A
T
G
C
T
G
T
C
A
G
G
C
C
C
A
A
G
C
A
T
T
G
G
C
C
A
G
G
A
C
0.09589
0.017613
0.043053
0.039139
0.033268
0.009785
0.005871
0.031311
0.060665
0.041096
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0.074364
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0.048924
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0.001957
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0.021526
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0.039139
0.029354
0.021526
0.02544
0.041096
0.017613
0.027397
0.031311
0
31,442
C
T
C
T
G
T
A
G
T
C
A
A
C
A
G
A
C
A
A
G
A
C
A
T
G
A
A
A
G
C
C
A
C
C
A
T
C
A
C
T
C
A
G
C
A
C
C
T
A
G
G
T
A
A
C
A
A
A
G
G
A
G
C
T
G
T
0.074364
0.035225
0.043053
0.027397
0.052838
0.021526
0.005871
0.039139
0.048924
0.027397
0.041096
0.031311
0.029354
0.033268
0.033268
0.037182
0.046967
0.027397
0.027397
0.005871
0.003914
0
0.02544
0.041096
0.033268
0.021526
0.023483
0.027397
0.02544
0.02544
0.039139
0.04501
0
31,443
A
A
G
C
C
A
T
C
G
C
A
T
C
C
C
C
T
G
T
G
A
C
T
T
G
C
A
G
G
T
A
T
C
T
G
C
C
C
A
G
A
T
G
G
C
C
T
G
A
A
G
T
A
A
C
T
G
A
A
G
A
A
T
C
A
A
0.064579
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0.054795
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0.003914
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0.035225
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0.029354
0.041096
0.046967
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0.04501
0.041096
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0.021526
0.043053
0.023483
0.029354
0.033268
0.023483
0.027397
0.033268
0.050881
0
31,444
A
T
C
A
T
T
A
A
C
T
T
A
C
T
T
T
T
C
A
T
C
A
T
T
A
G
G
A
A
A
G
A
T
T
A
T
T
T
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G
T
C
T
T
T
T
C
T
C
A
G
G
G
C
A
T
C
C
A
T
A
A
G
T
G
C
0.105675
0.017613
0.050881
0.068493
0.029354
0.013699
0.009785
0.041096
0.058708
0.009785
0.019569
0.046967
0.033268
0.054795
0.019569
0.019569
0.019569
0.021526
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0.005871
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0.003914
0.041096
0.017613
0.056751
0.017613
0.023483
0.009785
0.023483
0.039139
0.060665
0.039139
0
31,445
A
C
A
G
G
A
A
C
A
A
A
G
A
G
A
G
G
G
T
C
A
A
G
A
T
G
G
T
T
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T
C
T
T
T
C
C
T
C
C
T
G
G
C
T
T
C
C
A
A
C
A
C
A
A
C
C
T
G
C
T
T
T
G
T
C
0.064579
0.029354
0.046967
0.041096
0.046967
0.017613
0.003914
0.029354
0.054795
0.050881
0.037182
0.027397
0.019569
0.033268
0.043053
0.021526
0.050881
0.033268
0.02544
0.001957
0.001957
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0.031311
0.041096
0.037182
0.021526
0.037182
0.021526
0.033268
0.02544
0.037182
0.029354
0
31,446
G
G
A
A
C
A
A
A
G
A
G
A
G
G
G
T
C
A
A
G
A
T
G
G
T
T
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T
C
T
T
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C
C
T
C
C
T
G
G
C
T
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C
C
A
A
C
A
C
A
A
C
C
T
G
C
T
T
T
G
T
A
A
A
G
0.064579
0.029354
0.048924
0.041096
0.046967
0.017613
0.003914
0.027397
0.054795
0.050881
0.037182
0.027397
0.019569
0.033268
0.043053
0.021526
0.048924
0.033268
0.02544
0.001957
0.001957
0.003914
0.031311
0.041096
0.039139
0.021526
0.037182
0.021526
0.033268
0.023483
0.037182
0.031311
0
31,447
G
G
G
C
A
C
G
G
G
G
G
T
G
T
C
A
T
A
T
G
G
C
A
G
A
G
C
C
A
G
G
A
C
C
A
C
C
T
G
T
G
G
G
A
T
T
A
A
A
C
A
G
A
A
G
C
A
G
C
T
G
C
T
C
A
T
0.043053
0.037182
0.033268
0.039139
0.050881
0.037182
0.003914
0.031311
0.039139
0.031311
0.041096
0.019569
0.017613
0.041096
0.039139
0.039139
0.052838
0.04501
0.029354
0.009785
0.003914
0.005871
0.021526
0.037182
0.037182
0.02544
0.031311
0.029354
0.029354
0.021526
0.031311
0.04501
0
31,448
T
C
G
T
T
G
A
T
A
A
A
A
A
A
T
G
T
C
A
A
G
T
T
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T
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T
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A
C
C
C
C
A
A
T
T
G
T
G
G
C
C
C
C
T
T
T
G
0.064579
0.043053
0.039139
0.027397
0.04501
0.039139
0.015656
0.015656
0.035225
0.02544
0.058708
0.035225
0.02544
0.017613
0.041096
0.031311
0.046967
0.029354
0.052838
0.013699
0.007828
0.005871
0.015656
0.033268
0.039139
0.017613
0.02544
0.02544
0.037182
0.023483
0.029354
0.037182
0
31,449
C
A
C
A
C
A
T
G
T
G
G
C
T
C
C
C
A
T
C
A
T
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G
C
A
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A
T
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C
C
C
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G
G
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G
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G
G
G
G
T
C
T
G
A
A
T
C
C
T
C
T
G
C
A
T
G
A
G
T
A
A
0.039139
0.021526
0.037182
0.029354
0.062622
0.029354
0.007828
0.031311
0.04501
0.033268
0.043053
0.023483
0.027397
0.039139
0.029354
0.04501
0.046967
0.035225
0.033268
0.015656
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0.003914
0.033268
0.035225
0.029354
0.031311
0.035225
0.017613
0.046967
0.031311
0.029354
0.027397
0
31,450
A
G
A
C
C
A
A
C
A
T
T
C
A
A
G
G
C
C
A
G
G
T
G
C
C
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C
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C
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C
A
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C
C
C
A
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A
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C
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C
T
C
C
C
T
A
C
C
0.033268
0.027397
0.039139
0.035225
0.046967
0.02544
0.011742
0.035225
0.046967
0.033268
0.031311
0.04501
0.02544
0.058708
0.023483
0.02544
0.04501
0.037182
0.02544
0.009785
0.007828
0.001957
0.019569
0.04501
0.029354
0.021526
0.033268
0.021526
0.031311
0.04501
0.046967
0.035225
0
31,451
C
A
T
A
C
G
T
C
C
C
T
C
G
A
C
T
T
A
A
G
G
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A
C
T
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C
G
A
A
G
A
A
C
A
A
T
T
T
C
T
T
0.060665
0.033268
0.046967
0.029354
0.023483
0.043053
0.009785
0.023483
0.056751
0.027397
0.04501
0.009785
0.031311
0.027397
0.02544
0.033268
0.041096
0.054795
0.052838
0.009785
0.013699
0.001957
0.023483
0.041096
0.050881
0.013699
0.023483
0.027397
0.041096
0.019569
0.033268
0.02544
0
31,452
T
G
T
T
T
C
C
T
T
C
C
A
A
T
C
C
A
A
A
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T
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A
G
A
G
G
G
T
A
G
G
A
T
C
T
C
C
C
C
T
C
C
A
G
A
T
T
C
T
G
A
0.02544
0.021526
0.041096
0.033268
0.029354
0.027397
0.005871
0.019569
0.050881
0.033268
0.058708
0.017613
0.039139
0.031311
0.033268
0.027397
0.056751
0.064579
0.048924
0.009785
0.001957
0.001957
0.017613
0.046967
0.050881
0.017613
0.021526
0.037182
0.068493
0.015656
0.011742
0.033268
0
31,453
G
C
T
G
T
C
G
T
C
G
T
T
A
C
C
A
G
T
G
C
T
A
C
T
G
C
T
G
C
T
G
C
C
G
T
T
G
C
T
A
A
T
G
T
T
G
C
G
G
G
C
C
G
C
G
G
C
G
C
T
G
C
A
C
C
A
0.011742
0.019569
0.02544
0.011742
0.009785
0.033268
0.031311
0.017613
0.023483
0.062622
0.039139
0
0.009785
0.005871
0.013699
0.033268
0.060665
0.04501
0.082192
0.062622
0.033268
0.054795
0.009785
0.046967
0.033268
0.027397
0.043053
0.07045
0.04501
0.011742
0.009785
0.015656
0
31,454
T
A
C
T
T
A
C
A
G
C
T
G
G
A
T
A
A
A
T
T
T
T
A
G
G
A
G
A
T
C
T
T
C
G
G
T
T
C
C
T
A
A
C
A
T
T
C
C
A
G
C
A
T
A
A
G
A
T
A
C
T
G
G
G
T
T
0.091977
0.02544
0.050881
0.082192
0.043053
0.011742
0
0.031311
0.064579
0.021526
0.021526
0.052838
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0.043053
0.02544
0.015656
0.029354
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0.003914
0.005871
0.001957
0.043053
0.017613
0.058708
0.009785
0.027397
0.003914
0.019569
0.037182
0.074364
0.033268
0
31,455
A
G
A
G
T
A
C
A
G
A
A
G
A
A
T
G
A
C
T
A
C
A
G
A
G
C
C
C
A
C
G
A
C
G
A
C
A
G
T
C
T
G
G
C
A
C
A
G
A
G
A
C
A
T
A
C
C
C
T
A
A
A
A
C
A
T
0.072407
0.02544
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0.058708
0.060665
0.023483
0.009785
0.039139
0.048924
0.023483
0.019569
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0.039139
0.043053
0.033268
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0.007828
0
0.005871
0
0.033268
0.023483
0.029354
0.027397
0.023483
0.011742
0.017613
0.046967
0.052838
0.035225
0
31,456
T
C
C
C
T
G
G
C
T
G
A
G
A
A
A
T
A
A
T
A
T
A
A
C
A
A
C
G
C
A
A
A
T
A
A
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T
A
A
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T
T
A
C
C
T
T
G
A
C
C
A
G
A
A
G
C
C
A
A
A
G
G
A
T
C
0.103718
0.033268
0.050881
0.066536
0.033268
0.013699
0.005871
0.04501
0.037182
0.019569
0.029354
0.060665
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0.015656
0.046967
0.027397
0.035225
0.029354
0.013699
0
0.001957
0.007828
0.015656
0.029354
0.029354
0.017613
0.023483
0.019569
0.027397
0.019569
0.072407
0.039139
0
31,457
G
C
T
C
A
C
C
T
T
T
C
A
G
A
G
G
G
C
C
A
A
T
G
T
A
A
A
G
A
A
C
A
T
C
A
G
T
G
C
C
T
A
T
A
G
G
A
A
A
G
G
A
A
A
G
A
A
A
G
G
A
A
T
T
C
G
0.127202
0.037182
0.068493
0.066536
0.050881
0.013699
0.005871
0.029354
0.050881
0.019569
0.037182
0.04501
0.011742
0.021526
0.035225
0.023483
0.033268
0.013699
0.007828
0.001957
0
0
0.021526
0.013699
0.074364
0.011742
0.009785
0.017613
0.021526
0.027397
0.062622
0.039139
0
31,458
T
T
A
T
C
C
T
G
G
A
C
A
G
G
C
A
C
C
T
C
C
A
G
G
C
G
C
C
T
A
C
C
C
T
G
G
A
G
C
A
C
C
T
G
G
A
G
C
T
T
A
T
C
C
C
G
G
A
G
C
A
C
C
T
G
A
0.027397
0.007828
0.037182
0.015656
0.017613
0.037182
0.003914
0.011742
0.033268
0.050881
0.066536
0.017613
0.019569
0.037182
0.013699
0.027397
0.074364
0.07045
0.086106
0.015656
0
0.015656
0.021526
0.029354
0.033268
0.015656
0.041096
0.072407
0.043053
0.019569
0.015656
0.021526
0
31,459
G
C
C
A
T
A
G
G
G
G
C
C
A
G
T
G
G
C
A
G
G
G
T
A
G
G
C
T
C
C
G
G
T
G
G
C
A
C
T
T
G
G
C
T
G
T
C
C
A
G
A
A
G
A
T
G
G
G
T
A
G
G
C
C
C
G
0.023483
0.013699
0.037182
0.013699
0.021526
0.04501
0
0.021526
0.023483
0.046967
0.066536
0.023483
0.013699
0.031311
0.019569
0.035225
0.068493
0.072407
0.086106
0.013699
0
0.013699
0.021526
0.031311
0.023483
0.013699
0.037182
0.074364
0.033268
0.02544
0.023483
0.02544
0
31,460
G
C
A
A
C
C
T
T
G
A
A
G
T
G
G
T
C
A
G
G
T
T
C
A
A
C
C
A
G
T
A
C
T
T
G
T
A
T
C
T
G
A
A
A
T
G
G
C
A
T
A
T
A
C
A
T
A
A
A
C
T
G
T
T
A
A
0.099804
0.037182
0.031311
0.056751
0.04501
0.027397
0
0.037182
0.027397
0.013699
0.02544
0.052838
0.035225
0.062622
0.037182
0.02544
0.046967
0.035225
0.015656
0.001957
0.001957
0
0.009785
0.015656
0.043053
0.017613
0.031311
0.013699
0.021526
0.029354
0.041096
0.060665
0
31,461
C
T
T
A
T
T
T
C
C
T
T
C
A
G
C
T
A
A
A
G
A
T
C
T
T
A
T
T
C
G
C
A
C
A
G
C
A
G
T
T
G
G
T
C
A
A
A
C
A
A
G
A
C
T
C
C
T
T
A
T
G
A
A
G
G
T
0.117417
0.037182
0.041096
0.060665
0.039139
0.023483
0.003914
0.039139
0.021526
0.027397
0.035225
0.074364
0.02544
0.027397
0.046967
0.011742
0.033268
0.021526
0.013699
0.001957
0.003914
0.001957
0.031311
0.017613
0.031311
0.017613
0.021526
0.007828
0.027397
0.039139
0.060665
0.037182
0
31,462
T
T
G
G
C
T
T
A
A
C
A
T
T
G
G
T
C
T
T
T
T
C
T
G
G
A
A
C
A
A
G
C
C
C
T
T
G
A
G
A
T
G
T
C
T
C
A
T
C
T
A
A
T
T
C
A
A
C
A
A
G
A
A
T
T
T
0.125245
0.031311
0.056751
0.056751
0.048924
0.023483
0.003914
0.041096
0.048924
0.007828
0.031311
0.029354
0.015656
0.031311
0.041096
0.029354
0.031311
0.029354
0.009785
0.001957
0.007828
0.001957
0.017613
0.023483
0.054795
0.029354
0.011742
0.013699
0.02544
0.027397
0.050881
0.041096
0
31,463
T
T
C
C
C
A
A
G
C
C
T
C
T
G
A
A
T
T
G
C
C
C
A
C
A
G
A
T
G
C
T
G
T
T
G
A
T
T
G
T
A
T
G
A
G
C
A
G
A
G
A
G
C
T
T
G
T
G
T
C
C
C
T
T
A
C
0.052838
0.035225
0.041096
0.02544
0.046967
0.023483
0.007828
0.031311
0.048924
0.039139
0.039139
0.015656
0.029354
0.027397
0.04501
0.033268
0.064579
0.043053
0.033268
0.009785
0.007828
0.001957
0.017613
0.035225
0.043053
0.027397
0.037182
0.031311
0.037182
0.011742
0.013699
0.043053
0
31,464
G
G
A
A
A
A
A
A
G
T
G
G
G
T
C
T
G
C
T
G
A
G
C
C
A
T
T
T
G
T
A
C
T
G
C
C
A
G
C
C
T
C
T
T
C
T
G
T
G
G
A
A
A
G
T
A
C
A
T
T
A
C
C
A
G
C
0.072407
0.021526
0.052838
0.027397
0.037182
0.031311
0
0.043053
0.041096
0.043053
0.033268
0.013699
0.02544
0.033268
0.037182
0.033268
0.072407
0.058708
0.021526
0
0.001957
0.001957
0.011742
0.023483
0.039139
0.02544
0.041096
0.031311
0.029354
0.031311
0.02544
0.039139
0
31,465
T
C
A
T
A
A
G
G
T
A
C
A
A
C
T
G
G
G
C
T
G
A
A
C
A
G
G
G
G
A
G
A
C
C
T
G
G
G
T
G
G
G
G
C
A
A
G
G
C
C
A
T
C
C
T
A
G
G
C
A
G
T
T
C
C
A
0.054795
0.033268
0.039139
0.035225
0.054795
0.021526
0.007828
0.029354
0.041096
0.027397
0.043053
0.017613
0.033268
0.043053
0.035225
0.027397
0.068493
0.041096
0.023483
0.005871
0.007828
0.005871
0.023483
0.009785
0.048924
0.019569
0.041096
0.039139
0.029354
0.033268
0.023483
0.035225
0
31,466
A
C
C
T
T
C
C
A
T
A
T
T
C
T
T
C
G
G
T
C
C
A
G
T
T
A
T
A
G
A
T
A
C
T
T
T
T
T
G
T
A
A
G
T
T
T
A
A
T
C
C
A
T
T
C
C
T
C
A
G
G
G
T
T
G
T
0.119374
0.052838
0.039139
0.064579
0.052838
0.023483
0.001957
0.031311
0.041096
0.007828
0.02544
0.048924
0.017613
0.048924
0.046967
0.009785
0.023483
0.031311
0.023483
0.001957
0.005871
0.001957
0.021526
0.021526
0.054795
0.009785
0.017613
0.007828
0.029354
0.035225
0.054795
0.027397
0
31,467
T
A
A
T
A
A
T
G
A
T
C
C
A
T
A
T
G
T
T
A
C
T
G
G
A
G
C
A
G
G
G
G
C
T
T
T
A
G
A
A
T
T
C
C
A
G
A
T
G
T
A
A
T
A
A
T
C
A
G
A
A
G
A
A
A
T
0.11546
0.023483
0.043053
0.101761
0.031311
0.011742
0.001957
0.035225
0.041096
0.015656
0.009785
0.074364
0.035225
0.050881
0.035225
0.013699
0.021526
0.021526
0.005871
0.003914
0.005871
0
0.019569
0.015656
0.04501
0.023483
0.015656
0.003914
0.019569
0.017613
0.088063
0.052838
0
31,468
A
T
G
A
T
T
A
T
A
G
T
T
T
A
A
A
A
A
G
G
G
A
T
G
T
T
A
C
C
A
T
T
T
T
A
T
C
C
A
A
G
A
A
A
T
T
C
C
T
T
A
T
G
A
A
G
C
C
T
T
T
T
A
A
A
A
0.082192
0.027397
0.062622
0.07045
0.039139
0.017613
0
0.033268
0.041096
0.023483
0.027397
0.050881
0.039139
0.043053
0.046967
0.015656
0.017613
0.031311
0.019569
0.001957
0.005871
0.003914
0.033268
0.011742
0.04501
0.021526
0.013699
0.009785
0.031311
0.02544
0.068493
0.039139
0
31,469
A
G
C
A
G
A
C
A
G
G
C
T
C
T
C
C
T
G
A
A
G
C
C
A
A
G
G
A
G
T
T
A
T
G
A
A
A
A
A
G
G
C
A
G
G
C
A
T
C
G
C
G
C
A
T
T
G
A
A
T
C
A
A
G
T
C
0.076321
0.046967
0.052838
0.035225
0.043053
0.017613
0.009785
0.039139
0.050881
0.031311
0.035225
0.019569
0.017613
0.033268
0.037182
0.023483
0.048924
0.029354
0.007828
0.009785
0.007828
0.011742
0.021526
0.033268
0.054795
0.023483
0.029354
0.02544
0.031311
0.015656
0.041096
0.039139
0
31,470
G
C
T
T
C
C
C
T
T
T
G
A
T
T
T
C
T
T
T
T
T
G
C
C
T
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G
A
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C
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A
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A
T
G
A
A
G
A
G
G
A
T
G
A
A
G
A
A
G
A
T
G
0.060665
0.035225
0.052838
0.023483
0.037182
0.027397
0
0.027397
0.04501
0.021526
0.054795
0.039139
0.04501
0.052838
0.035225
0.019569
0.039139
0.041096
0.02544
0
0.005871
0.001957
0.019569
0.037182
0.046967
0.017613
0.021526
0.021526
0.046967
0.019569
0.031311
0.046967
0
31,471
A
G
A
G
A
C
T
C
A
G
G
T
G
A
G
A
A
C
G
G
A
G
A
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G
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C
T
C
A
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A
C
A
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C
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A
A
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G
C
C
A
T
G
A
G
G
G
T
A
T
G
G
A
A
G
G
A
G
T
0.023483
0.023483
0.048924
0.013699
0.04501
0.023483
0.009785
0.041096
0.039139
0.052838
0.035225
0.009785
0.02544
0.031311
0.029354
0.052838
0.064579
0.048924
0.041096
0.013699
0.007828
0.003914
0.007828
0.046967
0.039139
0.027397
0.033268
0.035225
0.041096
0.015656
0.017613
0.050881
0
31,472
A
G
A
T
T
T
T
T
C
G
G
C
T
T
C
T
T
T
C
T
T
A
A
C
T
T
C
T
T
C
T
G
T
T
T
T
T
T
C
C
A
T
T
T
T
G
T
T
C
C
C
A
A
A
A
A
T
C
T
G
T
A
C
T
A
C
0.125245
0.029354
0.078278
0.062622
0.027397
0.005871
0.003914
0.027397
0.088063
0.019569
0.015656
0.033268
0.037182
0.043053
0.037182
0.009785
0.021526
0.015656
0.005871
0.003914
0.003914
0
0.033268
0.015656
0.097847
0.017613
0.015656
0.007828
0.021526
0.007828
0.035225
0.052838
0
31,473
G
C
A
C
C
T
G
G
C
A
A
C
A
T
A
A
T
G
T
T
T
T
C
A
A
G
G
T
C
C
A
T
C
C
A
T
A
T
T
G
T
A
G
C
A
G
G
T
A
T
C
A
T
T
A
C
T
T
T
A
T
T
T
T
T
T
0.072407
0.019569
0.04501
0.035225
0.035225
0.031311
0.001957
0.023483
0.04501
0.041096
0.039139
0.023483
0.023483
0.039139
0.043053
0.035225
0.041096
0.043053
0.023483
0.019569
0.001957
0.007828
0.019569
0.043053
0.029354
0.019569
0.043053
0.039139
0.031311
0.019569
0.027397
0.037182
0
31,474
G
A
A
G
A
A
G
G
T
T
T
C
C
T
G
T
A
T
A
G
G
T
A
A
A
C
T
C
G
G
G
C
T
G
T
G
G
A
G
G
T
T
T
G
T
C
A
T
A
C
A
G
A
T
T
A
T
T
T
C
A
T
C
A
C
C
0.09002
0.043053
0.041096
0.035225
0.033268
0.027397
0.003914
0.04501
0.046967
0.013699
0.035225
0.046967
0.035225
0.039139
0.033268
0.023483
0.033268
0.035225
0.021526
0.005871
0.001957
0
0.035225
0.031311
0.046967
0.019569
0.019569
0.005871
0.043053
0.02544
0.041096
0.041096
0
31,475
A
A
A
A
A
C
G
G
C
C
A
A
G
C
C
A
G
C
C
T
C
G
C
A
A
G
A
A
C
A
T
G
C
T
C
G
G
T
G
T
T
C
C
G
C
C
A
T
T
G
G
G
A
C
A
G
G
G
G
A
G
T
C
C
C
T
0.039139
0.021526
0.046967
0.013699
0.039139
0.017613
0.007828
0.013699
0.050881
0.04501
0.066536
0.001957
0.007828
0.011742
0.029354
0.02544
0.062622
0.029354
0.074364
0.031311
0.021526
0.02544
0.007828
0.056751
0.04501
0.021526
0.037182
0.072407
0.037182
0.009785
0.007828
0.021526
0