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int64
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string
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string
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string
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f_65_alt
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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T
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C
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C
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C
C
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C
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C
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C
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31,178
G
A
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31,179
C
G
A
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C
C
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G
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T
T
T
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A
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C
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A
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C
T
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31,180
T
A
T
T
G
G
A
T
C
C
T
A
T
A
C
T
C
T
T
G
T
C
C
T
G
A
A
A
G
C
T
G
T
G
T
T
G
G
G
T
A
T
G
C
C
T
T
C
A
A
G
C
A
C
T
G
G
G
A
G
A
C
A
T
A
G
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31,181
C
A
A
T
G
C
A
A
A
T
A
G
T
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G
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C
C
T
G
G
G
T
C
A
C
A
C
A
C
A
A
C
A
T
G
G
T
C
A
A
T
A
A
T
G
T
T
T
G
G
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C
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A
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G
G
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C
T
T
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0
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0.021526
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0
31,182
C
A
A
C
C
A
A
A
G
G
C
A
T
A
G
C
T
G
G
G
G
G
T
T
C
A
T
G
A
C
T
G
T
A
A
G
G
T
A
G
C
G
C
A
A
A
G
G
G
T
T
A
C
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G
A
T
G
G
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A
A
C
A
T
C
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0
31,183
G
A
A
C
A
C
A
C
T
T
C
T
G
C
C
A
G
G
G
C
C
A
G
A
A
C
A
A
G
G
T
C
T
T
C
T
C
T
A
C
C
T
G
T
G
C
T
T
C
T
C
A
C
C
T
G
A
C
A
G
T
G
G
T
C
C
0.021526
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0
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0
31,184
A
G
C
A
G
G
T
G
G
A
C
A
T
G
G
C
C
C
T
G
T
T
G
G
T
A
T
T
C
T
C
A
C
C
T
G
A
G
C
C
T
G
A
A
T
G
T
T
T
C
T
T
G
A
G
C
A
A
G
G
C
C
A
G
A
T
0.037182
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0
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0.043053
0
31,185
T
C
A
C
C
A
T
A
A
A
G
T
C
A
G
A
C
C
C
T
G
G
G
C
T
C
A
C
A
G
C
C
C
C
C
C
T
C
T
A
T
T
T
C
T
T
T
C
T
G
G
G
C
A
A
C
T
T
G
G
C
C
T
T
C
G
0.041096
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0.035225
0
31,186
C
T
T
G
G
C
C
T
T
C
C
T
G
G
A
T
G
C
A
T
C
C
T
A
C
T
C
C
T
T
C
A
T
T
G
T
G
G
C
T
C
C
C
C
G
G
A
T
G
T
T
G
G
T
G
G
A
C
T
T
C
C
T
C
T
C
0.037182
0.019569
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0
0.029354
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0
31,187
G
C
T
A
C
A
T
C
G
C
C
A
T
C
T
G
C
C
G
G
C
C
T
C
T
G
C
A
C
T
A
T
C
C
T
A
C
T
G
T
C
A
T
G
A
A
C
C
C
T
A
G
A
A
C
C
T
G
C
T
A
T
G
C
A
T
0.029354
0.019569
0.046967
0.013699
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0.027397
0
0.02544
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0.048924
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0.009785
0.007828
0.035225
0
31,188
C
A
T
C
A
T
T
G
C
A
T
A
G
C
A
G
G
T
T
C
T
A
G
G
G
T
T
C
A
T
G
A
C
A
G
T
A
G
G
A
T
A
G
T
G
C
A
G
A
G
G
C
C
G
G
C
A
G
A
T
G
G
C
G
A
G
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0.019569
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0
0.027397
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0
31,189
C
T
T
C
A
T
C
C
T
C
T
T
G
G
T
G
A
T
C
T
C
T
T
A
C
A
C
T
A
T
C
A
T
C
C
T
G
G
T
C
A
C
C
G
T
T
C
G
G
C
A
G
C
G
T
T
C
C
T
C
T
G
G
T
G
C
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0
31,190
C
T
T
T
G
A
T
A
G
G
T
A
C
G
T
G
G
C
T
A
T
C
T
G
T
A
A
G
C
C
T
C
T
A
C
A
T
T
A
C
C
T
A
A
C
A
A
T
C
A
T
G
A
G
C
C
G
A
A
G
A
A
T
G
T
C
0.029354
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0
31,191
A
C
A
A
A
A
A
C
T
A
T
G
A
A
G
G
C
A
T
T
G
C
C
T
T
A
T
T
A
A
A
A
T
T
T
A
G
A
A
A
C
C
T
A
T
T
T
T
T
C
A
G
T
T
T
C
C
T
C
A
T
G
G
C
T
A
0.082192
0.033268
0.054795
0.060665
0.058708
0.011742
0
0.033268
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0
0
0
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0.066536
0.017613
0.021526
0.023483
0.015656
0.023483
0.039139
0.052838
0
31,192
A
T
T
C
C
T
T
A
G
T
G
T
A
T
A
A
A
T
A
A
T
G
G
G
G
T
T
T
A
G
G
A
C
G
G
G
G
G
T
G
A
A
A
A
C
A
G
T
G
T
A
A
A
A
T
A
T
G
G
C
A
A
G
A
A
T
0.066536
0.017613
0.050881
0.080235
0.037182
0.019569
0.005871
0.033268
0.04501
0.017613
0.035225
0.056751
0.015656
0.035225
0.041096
0.031311
0.023483
0.033268
0.021526
0.003914
0
0.001957
0.029354
0.027397
0.058708
0.015656
0.021526
0.021526
0.031311
0.031311
0.048924
0.041096
0
31,193
T
T
G
A
A
G
G
A
G
T
T
T
T
G
T
C
T
T
A
A
T
G
A
A
A
G
G
A
A
G
T
T
C
T
C
A
C
T
A
C
T
A
G
T
G
A
C
A
T
T
T
C
A
G
A
A
A
T
T
C
T
C
C
T
T
T
0.088063
0.023483
0.04501
0.074364
0.037182
0.019569
0.005871
0.033268
0.046967
0.005871
0.033268
0.072407
0.023483
0.041096
0.031311
0.029354
0.019569
0.031311
0.021526
0.003914
0
0.001957
0.035225
0.019569
0.054795
0.011742
0.019569
0.019569
0.029354
0.031311
0.056751
0.033268
0
31,194
G
G
G
C
C
A
T
G
C
A
A
C
C
C
T
C
A
A
A
G
G
A
G
A
T
A
G
T
C
T
T
G
C
G
C
T
C
A
A
T
A
A
A
A
A
A
G
T
C
T
A
C
A
A
G
C
A
T
C
T
T
G
G
G
G
T
0.060665
0.021526
0.04501
0.046967
0.048924
0.015656
0.003914
0.041096
0.058708
0.023483
0.019569
0.041096
0.02544
0.046967
0.050881
0.029354
0.033268
0.039139
0.02544
0.005871
0.005871
0.007828
0.029354
0.035225
0.037182
0.031311
0.027397
0.027397
0.021526
0.02544
0.02544
0.043053
0
31,195
C
C
T
T
G
C
A
T
T
T
A
T
T
T
C
T
A
T
A
T
A
T
G
G
C
C
T
T
T
T
A
G
C
A
G
A
C
T
T
C
C
T
G
T
G
G
A
C
A
A
A
T
T
T
C
T
T
T
C
T
G
T
G
T
T
A
0.048924
0.029354
0.037182
0.043053
0.046967
0.02544
0.005871
0.02544
0.041096
0.02544
0.037182
0.039139
0.035225
0.064579
0.02544
0.031311
0.041096
0.043053
0.021526
0.007828
0.009785
0
0.02544
0.02544
0.052838
0.023483
0.023483
0.02544
0.037182
0.019569
0.033268
0.048924
0
31,196
A
T
G
T
T
A
A
A
G
C
A
G
C
C
A
T
G
T
G
G
A
A
G
C
T
G
A
G
A
A
A
C
C
G
T
C
A
T
G
T
G
A
A
C
T
C
C
T
G
G
A
A
A
A
A
C
T
A
G
G
G
A
T
C
A
T
0.07045
0.033268
0.041096
0.056751
0.046967
0.021526
0.003914
0.033268
0.046967
0.015656
0.027397
0.041096
0.029354
0.056751
0.037182
0.027397
0.035225
0.035225
0.019569
0.007828
0.007828
0
0.023483
0.023483
0.050881
0.02544
0.027397
0.019569
0.029354
0.019569
0.041096
0.04501
0
31,197
A
T
G
A
T
C
C
C
T
A
G
T
T
T
T
T
C
C
A
G
G
A
G
T
T
C
A
C
A
T
G
A
C
G
G
T
T
T
C
T
C
A
G
C
T
T
C
C
A
C
A
T
G
G
C
T
G
C
T
T
T
A
A
C
A
T
0.072407
0.033268
0.041096
0.056751
0.046967
0.021526
0.003914
0.033268
0.046967
0.015656
0.027397
0.041096
0.029354
0.056751
0.037182
0.02544
0.035225
0.035225
0.019569
0.007828
0.007828
0
0.023483
0.023483
0.050881
0.02544
0.027397
0.019569
0.029354
0.019569
0.041096
0.04501
0
31,198
A
A
G
A
G
G
C
A
A
C
A
C
A
T
A
C
G
T
C
T
A
T
A
A
A
T
G
A
C
A
G
G
T
T
T
G
C
A
A
G
C
A
G
A
A
A
G
T
A
C
A
T
G
G
G
G
G
T
G
T
G
A
A
G
G
C
0.060665
0.035225
0.033268
0.041096
0.04501
0.023483
0.011742
0.031311
0.050881
0.02544
0.033268
0.023483
0.02544
0.054795
0.043053
0.029354
0.039139
0.027397
0.023483
0.007828
0.009785
0.005871
0.031311
0.037182
0.046967
0.029354
0.037182
0.021526
0.023483
0.017613
0.017613
0.056751
0
31,199
C
C
A
G
G
C
A
G
G
C
A
T
C
A
A
A
A
G
A
A
A
T
A
G
T
C
T
T
G
C
G
C
T
C
A
A
C
C
A
G
A
A
A
G
T
C
T
G
C
A
A
T
C
A
T
T
T
T
A
G
G
G
G
T
A
A
0.056751
0.035225
0.033268
0.037182
0.048924
0.02544
0.011742
0.033268
0.04501
0.02544
0.029354
0.02544
0.021526
0.056751
0.046967
0.035225
0.039139
0.039139
0.023483
0.007828
0.005871
0.005871
0.031311
0.031311
0.041096
0.029354
0.041096
0.029354
0.021526
0.019569
0.017613
0.048924
0
31,200
T
T
G
C
A
G
A
C
T
T
T
C
T
G
G
T
T
G
A
G
C
G
C
A
A
G
A
C
T
A
T
T
T
C
T
T
T
T
G
A
T
G
C
C
T
G
C
C
T
G
G
C
C
C
A
G
A
T
T
T
T
C
T
T
T
G
0.062622
0.037182
0.033268
0.033268
0.048924
0.027397
0.011742
0.035225
0.043053
0.02544
0.031311
0.02544
0.019569
0.054795
0.04501
0.035225
0.041096
0.039139
0.023483
0.007828
0.005871
0.005871
0.033268
0.027397
0.039139
0.029354
0.041096
0.029354
0.021526
0.021526
0.017613
0.046967
0
31,201
A
A
T
A
C
T
T
G
T
T
A
C
A
G
T
T
A
G
G
A
A
T
C
G
C
T
C
C
T
C
T
G
C
A
A
G
C
A
T
G
G
C
G
A
A
G
G
C
C
C
G
C
T
C
C
A
C
A
T
T
G
A
C
T
G
A
0.046967
0.033268
0.052838
0.027397
0.050881
0.02544
0.003914
0.050881
0.046967
0.033268
0.033268
0.027397
0.017613
0.041096
0.033268
0.037182
0.048924
0.035225
0.007828
0.003914
0.005871
0.009785
0.039139
0.02544
0.043053
0.031311
0.029354
0.02544
0.021526
0.029354
0.037182
0.04501
0
31,202
A
C
C
A
T
C
T
T
C
A
C
G
C
T
T
A
T
T
T
T
A
A
A
C
C
C
T
G
T
A
A
T
C
T
A
C
A
C
G
C
T
A
A
G
A
A
A
C
A
A
A
G
A
A
G
T
G
A
A
G
G
C
A
G
C
G
0.060665
0.035225
0.062622
0.029354
0.052838
0.015656
0.003914
0.054795
0.046967
0.033268
0.029354
0.02544
0.027397
0.031311
0.037182
0.035225
0.04501
0.027397
0.009785
0.003914
0.009785
0.009785
0.027397
0.027397
0.046967
0.023483
0.021526
0.021526
0.023483
0.033268
0.043053
0.04501
0
31,203
A
G
G
A
G
G
C
A
G
C
A
A
C
C
A
A
C
A
C
A
C
A
G
C
A
T
A
A
C
C
C
C
C
G
A
C
T
C
A
T
G
A
C
A
G
T
G
G
T
G
T
A
G
T
G
C
A
G
C
G
G
G
C
G
A
T
0.050881
0.031311
0.027397
0.035225
0.052838
0.033268
0.005871
0.033268
0.029354
0.027397
0.037182
0.015656
0.037182
0.052838
0.04501
0.046967
0.046967
0.04501
0.031311
0.003914
0.009785
0.007828
0.023483
0.029354
0.035225
0.02544
0.043053
0.015656
0.037182
0.019569
0.013699
0.050881
0
31,204
C
C
C
T
G
T
C
A
T
C
A
A
A
C
T
T
G
C
T
T
G
T
G
C
T
G
A
C
A
C
T
T
T
T
G
T
C
A
T
T
G
A
A
T
T
G
C
T
C
A
T
G
G
T
A
T
C
T
A
A
C
A
G
T
G
C
0.052838
0.02544
0.02544
0.02544
0.064579
0.033268
0.011742
0.031311
0.035225
0.02544
0.037182
0.011742
0.039139
0.041096
0.041096
0.060665
0.043053
0.050881
0.029354
0.003914
0.013699
0.013699
0.021526
0.039139
0.02544
0.027397
0.033268
0.017613
0.043053
0.027397
0.009785
0.039139
0
31,205
G
A
C
T
T
T
G
A
T
G
A
G
T
T
G
G
C
A
G
A
C
T
T
G
C
A
T
C
A
G
G
C
T
G
G
T
G
C
T
G
G
C
T
T
C
A
T
G
G
G
T
C
G
T
T
G
G
A
T
T
T
G
T
G
C
G
0.039139
0.017613
0.043053
0.019569
0.035225
0.027397
0.005871
0.031311
0.035225
0.039139
0.046967
0.021526
0.046967
0.054795
0.041096
0.039139
0.052838
0.056751
0.02544
0.001957
0.003914
0.003914
0.015656
0.039139
0.02544
0.023483
0.043053
0.035225
0.043053
0.019569
0.013699
0.052838
0
31,206
T
T
T
G
C
A
T
A
T
G
G
C
C
A
C
A
T
A
T
C
T
G
T
C
A
T
A
G
G
C
C
A
T
G
G
A
A
A
C
C
A
G
G
A
G
C
A
C
C
A
T
C
T
C
A
G
C
C
C
C
A
C
C
A
G
C
0.039139
0.015656
0.041096
0.027397
0.033268
0.031311
0.001957
0.033268
0.035225
0.027397
0.04501
0.02544
0.041096
0.062622
0.039139
0.037182
0.052838
0.062622
0.031311
0
0.001957
0
0.015656
0.033268
0.02544
0.02544
0.04501
0.041096
0.037182
0.021526
0.019569
0.050881
0
31,207
T
C
T
T
A
A
A
T
C
C
T
A
T
T
A
T
T
T
A
T
A
C
A
T
T
A
A
G
A
A
A
T
C
A
A
G
A
G
G
T
A
A
A
A
G
C
A
G
C
C
A
T
T
A
A
A
A
A
A
A
G
A
C
T
C
A
0.09589
0.031311
0.048924
0.04501
0.04501
0.019569
0.011742
0.041096
0.060665
0.027397
0.023483
0.041096
0.021526
0.033268
0.033268
0.031311
0.031311
0.019569
0.001957
0.007828
0.009785
0.001957
0.02544
0.046967
0.031311
0.02544
0.029354
0.011742
0.019569
0.031311
0.060665
0.035225
0
31,208
A
G
A
A
A
A
T
T
T
G
A
A
G
T
T
C
C
C
A
T
C
G
T
C
C
A
A
A
A
A
A
T
C
C
T
A
G
T
A
A
A
A
T
A
A
A
C
T
C
G
G
T
C
A
C
T
A
G
A
G
A
T
C
C
A
A
0.082192
0.027397
0.037182
0.062622
0.04501
0.023483
0.005871
0.037182
0.060665
0.009785
0.013699
0.054795
0.048924
0.041096
0.039139
0.039139
0.027397
0.035225
0.017613
0.003914
0.003914
0.001957
0.023483
0.033268
0.037182
0.023483
0.011742
0.003914
0.02544
0.021526
0.048924
0.052838
0
31,209
T
G
T
C
A
C
T
G
T
G
A
C
C
A
T
A
A
T
G
A
G
A
A
T
G
T
T
T
C
C
C
A
T
C
A
C
A
G
T
A
G
C
A
C
C
G
T
A
G
A
T
C
A
G
G
G
A
A
A
A
T
G
T
C
A
C
0.078278
0.02544
0.043053
0.046967
0.043053
0.027397
0.005871
0.035225
0.064579
0.009785
0.017613
0.043053
0.046967
0.050881
0.035225
0.039139
0.027397
0.039139
0.023483
0.003914
0.003914
0.001957
0.023483
0.033268
0.043053
0.027397
0.013699
0.007828
0.02544
0.019569
0.037182
0.056751
0
31,210
G
A
C
C
A
T
C
T
C
T
G
T
G
T
G
G
G
G
C
T
G
C
G
T
G
A
C
C
C
A
G
A
T
G
T
T
C
T
T
C
A
T
G
C
A
C
T
T
C
T
T
T
G
G
G
G
G
T
G
C
T
G
A
G
A
A
0.066536
0.02544
0.046967
0.031311
0.060665
0.02544
0.005871
0.02544
0.048924
0.019569
0.023483
0.029354
0.04501
0.062622
0.046967
0.04501
0.029354
0.04501
0.035225
0.001957
0.003914
0.003914
0.017613
0.02544
0.037182
0.027397
0.023483
0.019569
0.027397
0.019569
0.019569
0.054795
0
31,211
G
G
C
C
A
T
G
A
T
T
A
T
C
A
G
A
A
G
A
G
T
C
A
T
C
T
C
A
G
C
A
C
C
C
C
C
A
A
A
G
A
A
G
T
G
C
A
T
G
A
A
G
A
A
C
A
T
C
T
G
G
G
T
C
A
T
0.060665
0.02544
0.048924
0.031311
0.064579
0.02544
0.003914
0.023483
0.048924
0.02544
0.023483
0.031311
0.041096
0.064579
0.050881
0.046967
0.029354
0.041096
0.033268
0.001957
0.001957
0.003914
0.017613
0.02544
0.035225
0.02544
0.029354
0.019569
0.021526
0.021526
0.019569
0.056751
0
31,212
G
A
T
A
A
T
T
G
G
T
T
T
T
T
T
A
C
A
C
T
C
C
A
T
A
A
G
C
C
A
G
A
T
A
G
T
T
T
T
A
A
C
A
A
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G
A
A
C
T
T
G
C
C
T
T
T
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T
G
T
G
G
C
C
C
0.052838
0.02544
0.04501
0.033268
0.066536
0.02544
0.001957
0.019569
0.039139
0.037182
0.023483
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0.043053
0.064579
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0.043053
0.041096
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0.009785
0.011742
0.021526
0.02544
0.02544
0.035225
0.027397
0.017613
0.017613
0.021526
0.056751
0
31,213
T
T
C
T
T
G
T
T
C
A
T
G
A
T
G
G
T
C
A
T
G
T
A
G
T
G
T
A
G
G
G
G
C
T
T
A
C
A
A
A
T
G
G
C
C
A
C
A
T
A
T
C
T
G
T
C
A
A
A
A
G
C
C
A
T
G
0.066536
0.029354
0.050881
0.035225
0.054795
0.04501
0
0.029354
0.041096
0.027397
0.037182
0.041096
0.015656
0.04501
0.048924
0.037182
0.035225
0.043053
0.035225
0
0
0
0.021526
0.027397
0.035225
0.023483
0.023483
0.019569
0.015656
0.039139
0.031311
0.04501
0
31,214
A
C
A
G
A
A
C
A
A
T
G
C
A
T
T
T
T
G
T
G
A
C
T
G
A
G
T
T
T
G
T
C
C
T
C
C
T
G
G
G
T
T
T
C
C
A
T
G
G
T
C
A
A
A
G
G
G
A
G
A
T
G
C
A
G
G
0.058708
0.031311
0.041096
0.04501
0.04501
0.027397
0
0.027397
0.07045
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0.019569
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0.048924
0.035225
0.019569
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0.048924
0.054795
0.023483
0.027397
0.005871
0.04501
0.02544
0.027397
0.037182
0
31,215
C
C
C
A
A
A
C
A
T
G
C
T
A
G
T
C
A
A
T
A
T
C
C
T
C
T
C
T
G
A
G
A
T
T
A
A
A
A
C
C
A
T
C
T
C
C
T
T
C
T
C
T
G
G
T
T
G
C
T
T
C
C
T
G
C
C
0.046967
0.029354
0.029354
0.037182
0.048924
0.02544
0.001957
0.029354
0.064579
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0.029354
0.02544
0.056751
0.052838
0.031311
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0.039139
0.048924
0.02544
0.029354
0.017613
0.050881
0.02544
0.015656
0.029354
0
31,216
T
C
C
C
A
G
T
C
A
T
G
A
T
G
G
A
G
G
G
G
T
A
G
T
G
T
A
A
T
G
G
A
C
G
A
C
A
G
A
T
G
G
C
C
A
G
G
T
A
C
C
G
A
T
C
A
T
A
A
G
C
C
A
T
A
T
0.041096
0.027397
0.035225
0.033268
0.050881
0.027397
0.001957
0.031311
0.058708
0.021526
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0.039139
0.033268
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0.054795
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0.041096
0.021526
0.027397
0.029354
0.04501
0.027397
0.021526
0.027397
0
31,217
G
C
C
A
G
T
G
C
A
A
A
C
A
A
T
G
G
G
C
C
T
G
G
G
T
C
A
C
A
C
A
C
C
A
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G
T
G
G
T
C
A
A
T
G
A
T
G
T
T
G
G
G
C
C
C
A
C
A
G
A
A
G
G
G
A
0.031311
0.02544
0.041096
0.027397
0.046967
0.039139
0.001957
0.027397
0.058708
0.027397
0.031311
0.033268
0.037182
0.043053
0.029354
0.043053
0.050881
0.066536
0.039139
0.003914
0.011742
0.001957
0.017613
0.035225
0.041096
0.021526
0.023483
0.02544
0.037182
0.02544
0.02544
0.029354
0
31,218
T
C
T
T
T
G
G
G
C
C
C
T
T
C
C
T
C
T
C
C
A
T
C
T
T
G
G
G
A
T
C
T
T
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C
A
C
T
C
T
G
G
T
C
A
T
C
A
G
A
G
C
T
G
T
G
C
T
T
T
G
T
A
T
T
C
0.021526
0.023483
0.04501
0.027397
0.046967
0.033268
0
0.02544
0.062622
0.029354
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0.035225
0.043053
0.050881
0.027397
0.041096
0.048924
0.060665
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0.011742
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0.019569
0.037182
0.043053
0.023483
0.027397
0.019569
0.039139
0.017613
0.02544
0.033268
0
31,219
A
G
T
T
C
G
A
C
C
A
G
C
A
C
C
A
G
A
G
G
G
A
A
T
A
C
A
A
A
G
C
A
C
A
G
C
T
C
T
G
A
T
G
A
C
C
A
G
A
G
T
G
T
A
A
G
A
T
C
C
C
A
A
G
A
G
0.021526
0.029354
0.043053
0.027397
0.048924
0.035225
0
0.02544
0.064579
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0.031311
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0.04501
0.027397
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0.011742
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0.041096
0.023483
0.027397
0.019569
0.037182
0.017613
0.031311
0.029354
0
31,220
C
T
G
G
T
G
C
T
G
G
T
C
G
A
A
C
T
A
A
A
G
C
T
T
T
C
T
C
C
A
C
A
T
G
T
G
G
G
T
C
C
C
A
C
C
T
A
A
T
G
G
T
G
G
T
G
T
C
T
C
T
A
T
T
C
C
0.033268
0.029354
0.050881
0.02544
0.043053
0.031311
0
0.029354
0.062622
0.029354
0.029354
0.033268
0.043053
0.043053
0.035225
0.041096
0.04501
0.062622
0.041096
0
0.011742
0
0.019569
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0.041096
0.021526
0.023483
0.02544
0.035225
0.011742
0.029354
0.035225
0
31,221
A
A
G
C
A
T
G
A
A
T
A
A
C
T
C
A
C
A
G
A
T
A
T
C
T
A
C
T
G
T
G
A
C
G
C
A
G
T
T
T
G
T
G
T
T
G
T
T
G
G
G
G
T
T
T
C
C
T
G
G
T
C
C
C
T
T
0.07045
0.029354
0.037182
0.043053
0.041096
0.033268
0.005871
0.029354
0.058708
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0.017613
0.031311
0.046967
0.031311
0.029354
0.007828
0.035225
0.015656
0.017613
0.048924
0
31,222
A
C
T
C
A
C
A
G
A
T
A
T
C
T
A
C
T
G
T
G
A
C
G
C
A
G
T
T
T
G
T
G
T
T
G
T
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G
G
G
G
T
T
T
C
C
T
G
G
T
C
C
C
T
G
G
A
A
A
A
T
T
C
A
G
G
0.066536
0.031311
0.037182
0.041096
0.041096
0.033268
0.005871
0.029354
0.058708
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0.017613
0.031311
0.048924
0.029354
0.029354
0.007828
0.035225
0.015656
0.017613
0.050881
0
31,223
T
C
C
A
C
A
G
A
A
G
A
C
A
T
G
A
T
G
G
A
G
G
G
C
A
T
A
T
T
T
C
A
T
G
T
C
C
T
T
G
T
T
G
C
G
T
A
G
G
C
T
G
T
A
G
A
T
G
A
G
G
G
G
G
T
C
0.041096
0.033268
0.039139
0.033268
0.050881
0.031311
0.003914
0.023483
0.04501
0.029354
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0.037182
0.066536
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0.033268
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0.046967
0.023483
0
0.005871
0.005871
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0.033268
0.037182
0.021526
0.027397
0.019569
0.029354
0.021526
0.031311
0.048924
0
31,224
A
A
C
G
A
C
T
C
C
T
C
T
T
T
T
T
A
A
T
C
C
T
C
T
G
A
T
C
T
A
T
A
C
T
C
T
T
C
G
T
A
A
T
A
A
G
G
A
C
A
T
G
A
A
A
C
T
C
G
C
T
C
T
G
A
G
0.056751
0.039139
0.046967
0.033268
0.04501
0.02544
0.009785
0.04501
0.056751
0.021526
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0.023483
0.019569
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0.031311
0.009785
0.001957
0.021526
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0.023483
0.039139
0.050881
0.033268
0.015656
0.007828
0.035225
0.037182
0.04501
0.035225
0
31,225
C
C
A
T
C
T
G
C
T
G
T
A
G
G
G
T
T
T
T
C
T
C
C
A
T
C
T
C
C
T
T
C
T
G
C
A
C
A
T
C
C
T
G
T
T
G
C
T
T
C
C
T
C
C
C
A
G
C
A
T
C
C
T
C
A
C
0.054795
0.021526
0.035225
0.046967
0.031311
0.027397
0.005871
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0.041096
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0.048924
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0.041096
0.027397
0
0.009785
0
0.046967
0.041096
0.046967
0.013699
0.031311
0.019569
0.039139
0.035225
0.019569
0.043053
0
31,226
T
C
C
T
C
A
T
T
T
T
T
G
T
G
T
G
C
C
A
G
C
T
C
T
G
A
T
G
G
G
A
T
C
C
T
A
T
G
G
A
A
C
C
T
G
G
C
C
A
A
A
T
G
C
A
G
C
C
C
A
G
A
A
G
G
G
0.046967
0.02544
0.027397
0.027397
0.027397
0.031311
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0.029354
0.050881
0.029354
0.056751
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0.035225
0.019569
0.031311
0.039139
0.050881
0.013699
0.021526
0.037182
0
31,227
A
T
G
C
C
A
T
A
A
C
C
G
T
G
T
G
G
C
C
C
C
A
T
C
T
A
G
C
C
C
G
A
C
G
G
T
T
A
C
C
A
C
C
A
G
A
A
G
C
T
C
T
G
A
C
C
C
A
G
G
C
T
G
T
C
T
0.015656
0.021526
0.031311
0.003914
0.035225
0.04501
0.021526
0.019569
0.041096
0.048924
0.054795
0.007828
0.017613
0.033268
0.015656
0.052838
0.07045
0.058708
0.052838
0.023483
0.001957
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0.009785
0.052838
0.029354
0.037182
0.037182
0.039139
0.052838
0.009785
0.011742
0.039139
0
31,228
G
G
C
A
C
C
T
G
T
A
C
C
T
G
C
G
C
A
G
A
C
T
C
T
G
G
A
C
G
A
G
G
C
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G
G
C
A
A
A
C
G
G
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C
C
C
A
T
G
G
G
G
T
A
G
G
G
G
T
C
T
C
C
A
T
0.015656
0.023483
0.031311
0.009785
0.033268
0.033268
0.009785
0.033268
0.043053
0.058708
0.054795
0.009785
0.003914
0.015656
0.021526
0.041096
0.072407
0.048924
0.068493
0.021526
0.007828
0.011742
0.019569
0.064579
0.035225
0.027397
0.035225
0.043053
0.046967
0.017613
0.007828
0.033268
0
31,229
C
A
C
T
G
T
T
A
C
C
A
G
C
A
G
C
C
A
C
T
G
C
T
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C
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C
C
C
A
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C
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C
T
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G
T
C
C
C
C
T
T
C
G
G
T
A
G
T
G
T
C
C
G
C
C
A
C
A
C
A
G
0.013699
0.02544
0.027397
0.009785
0.029354
0.041096
0.009785
0.037182
0.035225
0.056751
0.046967
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0.072407
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0.027397
0.029354
0.037182
0.043053
0.043053
0.017613
0.007828
0.035225
0
31,230
C
T
G
A
C
T
T
T
G
T
T
T
C
T
G
A
G
T
C
T
G
A
A
G
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G
G
C
C
G
C
A
C
G
T
C
G
G
A
T
C
T
C
A
G
A
A
C
T
G
A
A
G
A
G
C
T
A
C
C
T
A
A
G
C
T
0.023483
0.019569
0.027397
0.013699
0.029354
0.037182
0.007828
0.02544
0.052838
0.054795
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0.019569
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0.082192
0.052838
0.046967
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0.017613
0.058708
0.029354
0.02544
0.041096
0.04501
0.039139
0.017613
0.003914
0.043053
0
31,231
C
A
G
C
A
G
C
T
G
A
A
C
G
T
C
C
G
G
A
A
T
G
T
G
G
C
C
A
A
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A
A
C
A
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C
T
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G
G
C
C
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T
T
G
C
T
G
C
T
T
T
C
T
T
G
C
C
G
G
C
G
T
G
A
0.035225
0.011742
0.046967
0.035225
0.029354
0.019569
0.015656
0.02544
0.037182
0.048924
0.054795
0.021526
0.017613
0.031311
0.033268
0.033268
0.062622
0.048924
0.029354
0.009785
0.007828
0.005871
0.013699
0.043053
0.04501
0.027397
0.043053
0.046967
0.048924
0.017613
0.013699
0.039139
0
31,232
T
C
T
C
C
T
T
G
G
A
G
A
A
C
C
G
G
T
G
C
C
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C
C
A
G
C
C
C
C
C
0.02544
0.02544
0.035225
0.011742
0.043053
0.035225
0.005871
0.02544
0.07045
0.037182
0.046967
0.019569
0.02544
0.041096
0.031311
0.039139
0.062622
0.064579
0.023483
0.005871
0
0.003914
0.027397
0.056751
0.035225
0.031311
0.033268
0.039139
0.043053
0.013699
0.005871
0.035225
0
31,233
T
G
G
G
G
T
G
G
G
A
A
C
C
A
A
A
G
C
T
A
T
G
T
G
C
T
G
C
A
C
A
G
C
G
G
G
C
A
G
T
G
T
C
A
G
G
A
T
G
C
A
G
G
C
A
G
G
C
A
T
C
T
C
A
G
T
0.033268
0.021526
0.031311
0.013699
0.033268
0.031311
0.007828
0.031311
0.033268
0.04501
0.058708
0.029354
0.015656
0.031311
0.023483
0.043053
0.060665
0.04501
0.064579
0.011742
0.005871
0.001957
0.027397
0.050881
0.027397
0.013699
0.052838
0.04501
0.041096
0.02544
0.015656
0.027397
0
31,234
C
C
C
C
C
T
T
G
C
C
T
G
C
T
T
A
C
C
T
C
C
A
G
A
C
A
T
T
G
A
G
C
T
C
A
G
G
G
T
T
G
T
A
G
G
T
C
T
C
C
A
C
A
G
A
G
T
C
C
A
G
G
G
C
A
C
0.023483
0.019569
0.041096
0.017613
0.033268
0.029354
0.007828
0.031311
0.04501
0.033268
0.062622
0.009785
0.021526
0.02544
0.043053
0.043053
0.056751
0.072407
0.046967
0.003914
0.005871
0.005871
0.021526
0.052838
0.023483
0.027397
0.041096
0.056751
0.054795
0.011742
0.011742
0.019569
0
31,235
C
T
G
G
G
G
T
C
A
G
G
G
G
T
G
G
A
A
G
T
A
G
C
C
C
G
G
C
T
G
C
C
C
G
C
A
C
C
C
T
C
C
G
C
A
A
C
T
C
C
C
T
G
G
T
G
G
A
C
A
T
G
C
G
G
T
0.011742
0.017613
0.02544
0.001957
0.031311
0.037182
0.011742
0.023483
0.023483
0.056751
0.056751
0.001957
0.019569
0.023483
0.029354
0.043053
0.076321
0.064579
0.064579
0.037182
0.007828
0.017613
0.013699
0.04501
0.011742
0.027397
0.050881
0.076321
0.04501
0.015656
0.003914
0.027397
0
31,236
C
G
C
A
A
T
C
A
G
C
A
G
C
C
T
C
T
T
C
C
G
A
G
A
C
A
G
G
C
T
G
C
T
G
G
G
C
G
G
C
G
G
A
G
G
T
C
C
G
C
G
G
C
C
C
C
C
C
T
T
C
A
G
C
C
A
0.013699
0.007828
0.035225
0.005871
0.015656
0.023483
0.005871
0.007828
0.039139
0.058708
0.068493
0.005871
0.019569
0.019569
0.009785
0.017613
0.076321
0.037182
0.084149
0.043053
0.029354
0.050881
0.005871
0.056751
0.037182
0.021526
0.052838
0.076321
0.048924
0.005871
0.001957
0.017613
0
31,237
A
G
C
C
T
G
G
T
T
C
C
A
G
G
C
C
C
C
T
G
G
T
C
C
C
A
A
G
G
A
A
C
C
T
T
C
C
C
T
T
T
C
C
A
G
C
C
T
T
G
T
C
C
C
T
A
G
A
G
G
A
A
G
A
A
T
0.011742
0.011742
0.035225
0.005871
0.017613
0.023483
0.013699
0.013699
0.048924
0.048924
0.068493
0.007828
0.02544
0.015656
0.017613
0.019569
0.07045
0.043053
0.060665
0.039139
0.02544
0.035225
0.005871
0.068493
0.033268
0.033268
0.04501
0.062622
0.068493
0.003914
0.001957
0.017613
0
31,238
A
A
T
C
C
T
C
T
T
T
A
C
A
G
A
C
T
T
G
G
G
G
T
T
T
C
A
T
G
G
A
C
T
T
C
C
T
C
A
T
C
A
C
C
C
T
T
A
G
G
T
G
A
T
T
G
C
A
T
A
C
T
C
G
G
A
0.068493
0.02544
0.043053
0.052838
0.029354
0.033268
0.005871
0.019569
0.039139
0.027397
0.043053
0.033268
0.035225
0.043053
0.031311
0.02544
0.039139
0.048924
0.033268
0.007828
0.013699
0
0.015656
0.033268
0.060665
0.011742
0.02544
0.013699
0.052838
0.02544
0.027397
0.035225
0
31,239
A
C
C
T
G
T
A
C
T
T
C
G
G
G
G
A
A
A
G
T
T
G
G
G
G
A
T
T
T
C
A
C
C
G
T
A
G
T
C
A
A
A
G
A
T
C
T
G
G
G
C
C
T
G
A
G
T
T
A
A
T
T
T
A
T
T
0.037182
0.019569
0.04501
0.037182
0.04501
0.027397
0.003914
0.037182
0.054795
0.021526
0.046967
0.021526
0.02544
0.033268
0.033268
0.039139
0.052838
0.039139
0.035225
0.009785
0.005871
0
0.021526
0.039139
0.046967
0.035225
0.031311
0.02544
0.043053
0.019569
0.023483
0.043053
0
31,240
A
G
A
A
G
G
A
G
T
G
T
A
T
T
G
T
A
A
T
T
T
A
A
C
A
G
A
A
G
C
A
T
T
T
G
A
A
A
T
A
C
C
A
G
C
G
T
G
T
A
A
A
T
A
C
G
A
A
T
C
A
C
T
T
T
C
0.07045
0.031311
0.039139
0.052838
0.04501
0.019569
0.023483
0.027397
0.041096
0.021526
0.035225
0.046967
0.027397
0.048924
0.035225
0.029354
0.027397
0.033268
0.011742
0.001957
0.007828
0.005871
0.023483
0.035225
0.050881
0.015656
0.021526
0.013699
0.037182
0.039139
0.039139
0.041096
0
31,241
A
T
T
A
T
A
A
T
G
T
A
A
A
C
T
T
C
T
G
A
A
T
G
T
C
A
G
T
A
A
T
G
T
G
G
A
A
G
A
C
A
T
A
T
C
A
T
C
C
T
T
G
G
A
C
A
T
G
C
T
G
A
G
G
C
A
0.046967
0.027397
0.046967
0.039139
0.048924
0.015656
0.005871
0.031311
0.058708
0.035225
0.023483
0.02544
0.031311
0.048924
0.033268
0.02544
0.066536
0.037182
0.021526
0.007828
0.007828
0.005871
0.007828
0.027397
0.046967
0.027397
0.052838
0.023483
0.029354
0.021526
0.035225
0.037182
0
31,242
A
G
T
G
G
G
A
G
G
T
A
C
A
G
G
T
A
G
A
G
A
A
G
G
C
C
T
T
C
T
G
A
C
G
G
C
C
T
G
A
A
G
C
A
G
A
G
G
G
G
A
T
G
C
T
C
A
G
G
A
C
T
G
C
C
T
0.023483
0.013699
0.054795
0.017613
0.046967
0.023483
0.015656
0.041096
0.035225
0.035225
0.052838
0.011742
0.019569
0.027397
0.031311
0.054795
0.060665
0.048924
0.029354
0.007828
0.009785
0.009785
0.019569
0.029354
0.037182
0.035225
0.043053
0.04501
0.041096
0.02544
0.017613
0.035225
0
31,243
G
G
C
C
A
C
A
G
C
C
A
C
T
G
T
G
G
G
A
C
C
A
A
G
C
A
C
A
G
G
G
A
C
G
A
G
T
C
C
C
C
C
C
A
C
C
C
A
G
C
A
G
G
C
C
A
A
G
G
C
C
A
C
A
C
T
0.017613
0.007828
0.050881
0.017613
0.046967
0.017613
0.009785
0.031311
0.041096
0.050881
0.052838
0.009785
0.023483
0.027397
0.035225
0.046967
0.07045
0.04501
0.037182
0.011742
0.013699
0.011742
0.015656
0.039139
0.035225
0.029354
0.052838
0.052838
0.037182
0.021526
0.003914
0.035225
0
31,244
T
G
T
G
T
T
T
C
T
T
C
T
T
G
T
C
T
A
T
C
T
C
C
T
G
A
A
T
C
T
G
A
C
A
G
G
C
A
A
T
G
T
G
T
T
G
A
T
T
G
T
G
G
G
G
G
T
G
G
T
A
A
G
G
G
T
0.037182
0.031311
0.035225
0.033268
0.052838
0.023483
0.001957
0.037182
0.050881
0.021526
0.043053
0.02544
0.039139
0.035225
0.041096
0.023483
0.062622
0.035225
0.031311
0.005871
0.011742
0.007828
0.019569
0.035225
0.041096
0.031311
0.031311
0.021526
0.041096
0.029354
0.019569
0.043053
0
31,245
G
G
A
G
G
G
C
T
G
G
A
C
C
A
G
C
C
C
C
A
G
C
C
C
C
A
G
C
A
G
G
G
T
C
A
G
C
A
G
C
A
A
A
A
G
C
A
G
A
A
G
C
A
A
T
G
A
A
T
G
G
G
T
C
C
A
0.031311
0.019569
0.052838
0.015656
0.015656
0.027397
0.009785
0.033268
0.052838
0.035225
0.043053
0.027397
0.041096
0.048924
0.037182
0.031311
0.054795
0.04501
0.029354
0.009785
0.005871
0.009785
0.019569
0.035225
0.043053
0.015656
0.072407
0.031311
0.039139
0.019569
0.007828
0.039139
0
31,246
T
A
A
G
C
T
A
T
A
G
A
T
G
A
A
C
A
T
A
T
G
A
A
A
G
C
T
C
T
T
G
C
C
T
T
T
C
A
G
A
G
C
C
T
C
T
T
T
T
T
C
T
C
T
C
A
T
G
A
G
G
A
C
A
T
A
0.041096
0.019569
0.04501
0.037182
0.04501
0.017613
0.009785
0.031311
0.062622
0.031311
0.031311
0.048924
0.02544
0.056751
0.035225
0.02544
0.037182
0.027397
0.021526
0.001957
0.011742
0.007828
0.023483
0.052838
0.04501
0.021526
0.035225
0.019569
0.023483
0.037182
0.023483
0.046967
0
31,247
T
G
A
C
A
G
G
C
T
T
T
G
A
G
C
T
C
T
G
G
T
G
G
C
A
G
T
T
G
T
G
C
C
G
A
C
G
A
T
T
T
T
T
G
C
A
G
A
C
A
A
T
G
C
T
G
A
G
C
A
A
A
T
C
A
T
0.046967
0.021526
0.04501
0.037182
0.04501
0.017613
0.003914
0.041096
0.041096
0.04501
0.027397
0.02544
0.019569
0.043053
0.046967
0.033268
0.064579
0.039139
0.029354
0.003914
0.005871
0.005871
0.017613
0.027397
0.041096
0.027397
0.062622
0.027397
0.02544
0.02544
0.013699
0.043053
0
31,248
A
T
G
G
A
G
A
G
C
T
C
A
T
C
A
T
C
T
C
C
C
T
G
G
G
C
T
T
C
T
T
T
T
T
T
G
T
C
T
T
C
T
T
T
T
T
G
G
A
G
T
C
G
C
T
G
G
C
A
T
T
G
C
A
G
C
0.04501
0.013699
0.041096
0.02544
0.048924
0.015656
0.003914
0.023483
0.04501
0.050881
0.04501
0.009785
0.021526
0.048924
0.035225
0.031311
0.048924
0.048924
0.048924
0.009785
0.015656
0.001957
0.023483
0.048924
0.039139
0.027397
0.041096
0.039139
0.048924
0.019569
0.005871
0.027397
0
31,249
A
G
C
T
A
T
T
G
C
A
G
A
C
T
T
T
T
A
G
A
C
G
A
A
A
G
A
A
G
G
G
A
T
C
A
C
A
C
T
T
T
T
T
C
T
C
T
T
G
A
A
G
T
T
G
T
A
T
A
A
G
A
G
A
T
C
0.062622
0.023483
0.050881
0.031311
0.04501
0.011742
0.007828
0.041096
0.046967
0.027397
0.021526
0.037182
0.029354
0.046967
0.037182
0.039139
0.033268
0.046967
0.033268
0.009785
0.009785
0.007828
0.015656
0.037182
0.035225
0.027397
0.02544
0.037182
0.031311
0.015656
0.033268
0.041096
0
31,250
C
C
C
T
G
A
C
C
A
T
G
T
G
T
A
A
G
C
T
C
A
C
C
T
C
A
G
G
G
A
A
G
C
A
T
C
C
G
A
A
C
T
G
C
A
G
G
T
A
C
A
A
A
G
A
G
A
A
G
C
G
A
C
A
G
T
0.043053
0.02544
0.043053
0.019569
0.039139
0.035225
0.011742
0.02544
0.041096
0.043053
0.052838
0.003914
0.007828
0.031311
0.033268
0.043053
0.064579
0.052838
0.041096
0.011742
0.007828
0.007828
0.007828
0.048924
0.037182
0.02544
0.046967
0.043053
0.039139
0.017613
0.017613
0.031311
0
31,251
T
G
C
T
C
C
A
T
C
C
T
G
G
C
C
C
C
G
A
G
G
C
C
C
C
A
G
G
C
C
C
T
T
C
T
G
G
T
G
C
A
T
C
C
A
C
G
C
C
C
G
G
T
G
T
C
T
C
C
G
G
T
G
G
C
C
0.001957
0.005871
0.02544
0.001957
0.019569
0.035225
0.009785
0.011742
0.029354
0.048924
0.091977
0.001957
0.011742
0.011742
0.011742
0.033268
0.068493
0.058708
0.103718
0.039139
0.007828
0.021526
0.003914
0.084149
0.017613
0.023483
0.029354
0.072407
0.080235
0.013699
0.003914
0.019569
0
31,252
C
A
T
G
T
G
G
G
T
T
T
C
A
G
G
A
A
G
T
G
G
T
A
A
G
G
C
T
A
T
G
T
C
G
C
C
T
G
T
G
C
C
A
A
G
G
T
G
T
G
C
T
G
G
G
C
T
C
G
G
T
A
C
G
G
T
0.023483
0.033268
0.037182
0.019569
0.017613
0.029354
0.003914
0.037182
0.035225
0.033268
0.058708
0.011742
0.029354
0.033268
0.027397
0.027397
0.066536
0.056751
0.072407
0.011742
0.003914
0.003914
0.013699
0.046967
0.039139
0.013699
0.04501
0.041096
0.054795
0.013699
0.023483
0.035225
0
31,253
T
C
G
G
T
A
G
C
C
C
C
G
T
G
G
G
C
T
C
G
C
C
T
C
C
T
C
T
C
C
C
A
C
G
T
G
T
T
G
C
T
G
G
A
T
C
C
T
C
C
T
C
T
C
T
A
G
C
T
C
T
T
G
G
C
G
0.003914
0.003914
0.017613
0.005871
0.009785
0.013699
0.015656
0.011742
0.027397
0.072407
0.060665
0.001957
0.015656
0.023483
0.015656
0.029354
0.084149
0.076321
0.109589
0.037182
0.017613
0.019569
0.009785
0.060665
0.011742
0.013699
0.052838
0.113503
0.046967
0.003914
0
0.013699
0
31,254
A
C
T
G
G
A
G
A
A
T
G
G
T
C
T
G
G
C
T
G
C
G
C
T
C
A
G
T
C
C
C
T
T
A
A
G
C
A
A
G
G
T
A
A
C
T
T
T
T
T
C
T
C
C
A
A
C
C
T
T
C
A
G
G
A
C
0.041096
0.021526
0.033268
0.015656
0.02544
0.039139
0.003914
0.029354
0.050881
0.033268
0.068493
0.015656
0.017613
0.017613
0.023483
0.031311
0.066536
0.054795
0.058708
0.013699
0.003914
0.005871
0.019569
0.062622
0.029354
0.027397
0.031311
0.039139
0.056751
0.017613
0.017613
0.027397
0
31,255
C
A
A
G
C
T
C
A
A
G
G
G
C
C
C
T
G
A
A
G
G
G
G
G
G
T
C
A
G
A
G
A
T
G
T
T
T
G
T
T
T
A
C
A
A
G
C
A
G
G
C
C
T
T
T
A
A
G
G
T
A
C
G
A
T
C
0.04501
0.027397
0.054795
0.023483
0.037182
0.02544
0.001957
0.02544
0.058708
0.023483
0.066536
0.015656
0.033268
0.033268
0.029354
0.023483
0.050881
0.029354
0.041096
0.001957
0.021526
0.001957
0.023483
0.04501
0.054795
0.023483
0.031311
0.037182
0.035225
0.015656
0.021526
0.041096
0
31,256
A
G
G
G
G
C
T
A
A
A
A
A
C
T
G
C
A
A
A
T
A
C
C
G
T
A
T
A
G
G
A
T
T
C
A
T
C
C
C
C
T
T
G
T
T
T
C
A
A
A
C
C
T
T
G
G
A
G
C
C
T
G
C
A
G
C
0.031311
0.015656
0.027397
0.029354
0.02544
0.007828
0.003914
0.019569
0.052838
0.041096
0.074364
0.009785
0.019569
0.039139
0.015656
0.017613
0.060665
0.033268
0.09589
0.009785
0.001957
0.003914
0.011742
0.086106
0.041096
0.015656
0.037182
0.039139
0.07045
0.009785
0.015656
0.037182
0
31,257
C
A
T
A
A
A
A
A
G
T
G
T
T
G
T
G
C
C
A
A
A
G
A
A
G
A
G
G
C
A
G
A
T
G
G
C
A
G
T
G
A
G
G
T
G
G
G
A
T
G
C
A
C
A
G
G
T
G
G
A
A
A
A
T
G
C
0.058708
0.021526
0.050881
0.02544
0.046967
0.04501
0.001957
0.027397
0.04501
0.02544
0.048924
0.009785
0.033268
0.041096
0.033268
0.054795
0.04501
0.039139
0.031311
0.005871
0.003914
0.007828
0.015656
0.035225
0.039139
0.023483
0.037182
0.019569
0.029354
0.021526
0.02544
0.050881
0
31,258
T
G
C
A
C
A
C
A
C
C
C
A
T
G
T
A
C
T
C
C
C
T
C
C
T
G
A
A
G
A
G
C
C
T
C
T
C
C
T
T
C
T
T
G
G
A
T
T
T
C
T
G
C
T
A
C
T
C
C
T
C
C
A
C
G
T
0.023483
0.02544
0.031311
0.009785
0.033268
0.041096
0.003914
0.027397
0.046967
0.039139
0.052838
0.013699
0.02544
0.048924
0.027397
0.050881
0.054795
0.060665
0.041096
0.007828
0.007828
0.011742
0.015656
0.064579
0.033268
0.013699
0.043053
0.041096
0.039139
0.015656
0.005871
0.043053
0
31,259
C
C
G
G
G
A
C
C
T
G
C
G
G
G
T
C
G
C
G
G
A
G
G
A
G
G
C
G
G
C
G
C
C
G
C
T
C
T
C
G
G
A
G
A
C
C
G
C
A
A
G
G
C
G
C
G
G
G
C
A
G
A
A
G
G
A
0.023483
0.011742
0.029354
0.027397
0.035225
0.033268
0.013699
0.019569
0.037182
0.033268
0.041096
0.02544
0.023483
0.023483
0.021526
0.043053
0.050881
0.039139
0.052838
0.048924
0.011742
0.050881
0.017613
0.033268
0.019569
0.031311
0.041096
0.058708
0.037182
0.015656
0.027397
0.021526
0
31,260
A
T
A
A
A
T
G
A
G
A
A
G
A
A
C
T
C
A
C
A
G
T
T
C
A
C
T
G
G
G
T
T
T
A
C
T
G
G
C
T
A
C
T
T
C
A
C
C
T
C
T
G
T
T
T
T
C
A
T
T
T
G
T
C
G
C
0.084149
0.041096
0.043053
0.035225
0.039139
0.02544
0.003914
0.041096
0.043053
0.021526
0.039139
0.013699
0.015656
0.046967
0.037182
0.017613
0.043053
0.029354
0.035225
0.007828
0.011742
0.003914
0.019569
0.039139
0.052838
0.029354
0.027397
0.017613
0.033268
0.021526
0.031311
0.048924
0
31,261
C
C
C
C
A
A
G
G
G
G
T
G
T
G
A
T
A
T
G
A
C
G
T
C
T
T
T
A
T
T
A
T
C
C
A
G
T
T
T
C
A
G
C
A
T
C
T
C
C
T
G
G
A
C
C
T
A
G
T
T
C
C
T
C
A
T
0.046967
0.027397
0.043053
0.017613
0.027397
0.021526
0.005871
0.039139
0.04501
0.066536
0.035225
0.029354
0.02544
0.041096
0.035225
0.013699
0.068493
0.046967
0.027397
0.001957
0.001957
0.001957
0.019569
0.054795
0.035225
0.033268
0.035225
0.013699
0.048924
0.019569
0.017613
0.052838
0
31,262
C
T
T
T
T
C
T
T
T
G
T
G
A
T
C
T
C
T
A
T
T
A
T
C
A
T
T
G
T
C
A
G
C
T
T
T
T
G
T
C
A
T
C
A
T
T
G
C
C
T
C
C
A
G
T
T
C
C
T
C
C
T
G
A
A
A
0.050881
0.031311
0.066536
0.023483
0.031311
0.035225
0.005871
0.035225
0.050881
0.037182
0.052838
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0.023483
0.02544
0.046967
0.027397
0.037182
0.035225
0.019569
0.003914
0.005871
0.003914
0.041096
0.031311
0.046967
0.033268
0.02544
0.023483
0.033268
0.015656
0.027397
0.043053
0
31,263
T
G
G
G
C
T
G
G
C
A
G
T
G
T
T
T
C
C
A
A
A
C
A
T
A
A
C
G
A
C
A
A
C
G
G
T
C
G
G
G
T
G
C
C
A
T
A
A
G
C
A
A
C
A
T
C
T
T
T
G
A
G
C
T
G
T
0.056751
0.029354
0.04501
0.027397
0.035225
0.035225
0.009785
0.019569
0.043053
0.035225
0.046967
0.035225
0.031311
0.035225
0.035225
0.037182
0.041096
0.050881
0.039139
0.009785
0.005871
0.001957
0.027397
0.031311
0.046967
0.015656
0.029354
0.027397
0.043053
0.017613
0.021526
0.033268
0
31,264
T
T
T
A
G
T
G
C
T
T
C
A
G
A
G
T
T
T
T
T
A
A
G
G
T
C
T
T
A
C
C
T
C
T
G
G
T
G
T
A
T
T
T
C
C
A
T
T
T
A
A
G
A
T
G
T
T
A
A
G
G
C
T
A
A
G
0.046967
0.027397
0.048924
0.031311
0.033268
0.035225
0.001957
0.023483
0.066536
0.037182
0.04501
0.023483
0.037182
0.029354
0.027397
0.037182
0.048924
0.043053
0.021526
0.009785
0.007828
0
0.031311
0.043053
0.046967
0.007828
0.031311
0.037182
0.02544
0.023483
0.035225
0.035225
0
31,265
A
G
G
G
A
C
C
A
G
T
T
C
A
C
T
T
G
C
T
G
A
T
G
A
A
T
T
C
C
C
C
A
C
A
T
C
A
C
C
A
C
C
T
C
C
A
C
C
A
T
C
C
T
G
G
T
T
C
A
T
C
T
G
A
T
T
0.021526
0.017613
0.041096
0.021526
0.029354
0.035225
0.001957
0.02544
0.04501
0.043053
0.052838
0.009785
0.039139
0.037182
0.035225
0.02544
0.066536
0.080235
0.058708
0
0.007828
0.001957
0.005871
0.052838
0.031311
0.033268
0.019569
0.029354
0.068493
0.013699
0.013699
0.035225
0
31,266
C
A
C
C
T
T
G
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
A
T
T
A
C
A
G
G
T
G
T
G
A
G
C
C
A
C
C
G
T
G
C
C
T
G
G
C
C
T
A
A
A
T
A
A
A
T
A
A
T
C
0.04501
0.021526
0.046967
0.037182
0.027397
0.031311
0.005871
0.043053
0.046967
0.021526
0.050881
0.015656
0.029354
0.023483
0.048924
0.04501
0.039139
0.054795
0.017613
0.007828
0.007828
0.001957
0.031311
0.04501
0.035225
0.017613
0.041096
0.04501
0.039139
0.023483
0.019569
0.033268
0
31,267
A
G
G
G
C
C
A
T
G
G
A
G
T
T
G
G
G
G
A
G
A
G
A
A
T
G
T
C
T
A
A
A
C
C
T
C
T
G
G
G
G
G
T
A
A
G
T
A
G
T
G
G
T
T
G
T
G
T
T
G
C
T
T
T
C
T
0.093933
0.050881
0.035225
0.039139
0.050881
0.031311
0.009785
0.039139
0.048924
0.011742
0.021526
0.046967
0.017613
0.04501
0.037182
0.031311
0.02544
0.031311
0.035225
0.007828
0.005871
0.003914
0.035225
0.02544
0.046967
0.011742
0.021526
0.013699
0.013699
0.037182
0.041096
0.033268
0
31,268
C
C
T
G
G
G
G
C
C
C
A
G
A
G
A
G
G
A
G
A
G
G
A
G
A
G
G
A
G
T
C
T
T
C
A
G
G
G
C
A
T
T
T
C
C
T
G
G
T
C
G
C
T
G
C
C
A
C
A
G
G
T
A
C
A
C
0.003914
0.017613
0.015656
0.029354
0.017613
0.043053
0.007828
0.019569
0.041096
0.029354
0.060665
0.009785
0.033268
0.021526
0.027397
0.033268
0.076321
0.060665
0.09589
0.019569
0.009785
0.017613
0.007828
0.050881
0.027397
0.021526
0.048924
0.048924
0.048924
0.013699
0.007828
0.033268
0
31,269
G
A
T
A
A
T
T
G
G
G
G
G
C
C
A
G
G
A
G
A
A
C
C
C
C
A
A
C
A
A
C
T
C
T
T
C
G
G
C
C
T
C
C
T
C
T
G
A
A
C
C
C
C
G
G
C
C
T
G
A
G
G
G
T
C
G
0.001957
0.027397
0.017613
0.029354
0.023483
0.048924
0.007828
0.021526
0.04501
0.027397
0.056751
0.009785
0.021526
0.017613
0.033268
0.035225
0.058708
0.064579
0.093933
0.017613
0.013699
0.023483
0.013699
0.060665
0.02544
0.023483
0.029354
0.04501
0.046967
0.015656
0.015656
0.027397
0
31,270
C
A
G
G
T
A
G
A
T
G
A
A
G
G
C
A
C
A
G
G
G
C
A
C
A
T
A
G
T
A
C
A
C
G
G
T
G
A
C
C
A
C
G
G
T
T
A
C
A
T
G
G
G
C
T
C
C
A
C
A
A
G
T
T
G
T
0.02544
0.029354
0.033268
0.023483
0.046967
0.029354
0.011742
0.029354
0.035225
0.035225
0.050881
0.011742
0.027397
0.027397
0.031311
0.048924
0.058708
0.048924
0.050881
0.019569
0.005871
0.009785
0.023483
0.035225
0.039139
0.017613
0.02544
0.054795
0.033268
0.019569
0.015656
0.04501
0
31,271
C
A
T
G
A
G
G
C
G
A
G
G
G
A
C
A
A
T
G
A
T
G
G
A
G
G
A
G
A
T
G
C
T
C
A
T
A
T
C
A
A
T
G
A
C
T
G
A
G
A
G
A
A
C
A
C
C
A
A
G
A
A
A
G
A
C
0.039139
0.021526
0.033268
0.027397
0.04501
0.023483
0.003914
0.02544
0.041096
0.041096
0.04501
0.023483
0.037182
0.052838
0.031311
0.033268
0.056751
0.050881
0.035225
0.003914
0.001957
0.013699
0.02544
0.037182
0.033268
0.02544
0.031311
0.033268
0.043053
0.017613
0.019569
0.046967
0
31,272
A
A
T
T
A
A
C
A
T
G
A
A
G
C
A
A
C
T
G
G
C
G
G
C
C
A
C
T
A
C
C
C
C
G
A
C
G
T
C
C
A
C
A
A
A
G
G
T
C
A
C
A
A
G
C
T
C
A
T
T
G
A
C
A
G
T
0.015656
0.015656
0.023483
0.023483
0.046967
0.035225
0.009785
0.031311
0.021526
0.033268
0.046967
0.027397
0.023483
0.046967
0.027397
0.043053
0.058708
0.058708
0.052838
0.017613
0.007828
0.019569
0.023483
0.027397
0.015656
0.035225
0.031311
0.056751
0.033268
0.031311
0.019569
0.039139
0
31,273
A
C
C
C
G
A
A
G
C
T
C
T
G
T
G
C
T
C
G
C
C
C
C
A
T
G
T
A
C
A
T
T
C
T
T
C
T
G
G
G
A
G
T
G
C
T
C
T
C
A
T
T
C
C
T
G
G
A
C
A
T
G
T
G
G
T
0.039139
0.017613
0.039139
0.02544
0.048924
0.033268
0.009785
0.019569
0.046967
0.046967
0.037182
0.013699
0.021526
0.052838
0.027397
0.046967
0.054795
0.054795
0.039139
0.007828
0.005871
0.007828
0.013699
0.043053
0.04501
0.027397
0.031311
0.027397
0.037182
0.019569
0.011742
0.046967
0
31,274
A
G
T
G
C
A
G
A
T
A
G
C
C
A
C
G
T
A
A
C
G
A
T
C
A
T
A
C
G
C
C
A
T
A
A
T
G
A
T
C
A
G
C
A
G
A
A
A
G
A
T
C
T
C
G
G
C
A
C
A
G
G
C
A
A
C
0.029354
0.021526
0.043053
0.029354
0.056751
0.019569
0.011742
0.033268
0.058708
0.031311
0.027397
0.035225
0.039139
0.048924
0.039139
0.039139
0.048924
0.037182
0.029354
0.003914
0.007828
0.003914
0.023483
0.035225
0.033268
0.027397
0.035225
0.027397
0.021526
0.033268
0.021526
0.046967
0
31,275
T
G
A
A
G
T
G
G
G
C
C
G
A
G
C
A
G
G
T
A
G
A
C
A
G
G
G
C
T
T
T
C
C
G
G
C
G
C
C
C
T
T
C
A
G
C
T
G
A
G
T
G
T
T
T
T
C
G
A
A
G
A
G
A
A
T
0.033268
0.019569
0.04501
0.02544
0.046967
0.041096
0.005871
0.029354
0.04501
0.027397
0.046967
0.033268
0.021526
0.037182
0.033268
0.046967
0.048924
0.048924
0.035225
0.009785
0.011742
0.003914
0.019569
0.035225
0.04501
0.027397
0.021526
0.041096
0.023483
0.029354
0.011742
0.048924
0