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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
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C
C
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C
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33,282
T
G
T
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C
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C
A
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T
C
C
A
C
A
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0
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C
A
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A
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T
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A
A
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A
A
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A
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A
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C
T
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A
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A
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A
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A
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G
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A
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C
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C
C
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C
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A
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33,284
T
T
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A
A
C
C
T
C
C
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T
C
A
T
T
A
G
C
C
T
A
T
A
T
T
G
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G
C
G
A
C
A
T
C
A
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A
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A
G
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C
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T
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G
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33,285
G
C
G
G
T
A
G
A
G
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C
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C
T
G
T
G
G
G
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C
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T
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C
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C
C
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G
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G
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G
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G
G
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T
G
A
T
A
A
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0
33,286
G
C
A
G
G
A
A
C
A
G
T
G
T
T
G
G
G
G
T
T
G
G
A
G
A
G
C
T
G
G
G
G
T
T
G
G
G
A
G
G
C
T
G
A
A
T
C
T
G
G
G
A
G
A
A
A
G
A
G
A
A
A
T
T
A
C
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33,287
G
G
A
G
G
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C
G
A
G
G
T
A
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A
G
A
T
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C
A
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A
G
A
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G
C
T
G
G
C
G
A
A
A
G
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A
G
A
A
G
A
C
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A
A
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C
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C
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0.027397
0
33,288
C
A
C
T
T
C
C
T
C
T
C
C
A
G
T
C
C
C
T
C
C
T
G
C
A
G
C
G
T
C
T
C
T
G
C
T
C
T
G
G
G
C
C
C
T
G
C
C
A
T
C
T
C
C
T
G
C
T
G
T
C
C
C
T
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0
33,289
T
G
A
C
T
G
G
G
T
C
C
C
A
A
A
G
T
G
A
G
G
G
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A
C
G
G
G
G
G
C
C
A
G
C
A
G
G
G
A
T
G
G
G
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A
A
G
G
G
G
T
A
G
G
G
A
A
A
G
A
G
A
C
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0
33,290
T
T
C
C
C
T
A
C
C
C
C
T
T
G
C
C
C
A
T
C
C
C
T
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C
T
G
G
C
C
C
C
C
G
T
G
A
C
C
C
T
C
A
C
T
T
T
G
G
G
A
C
C
C
A
G
T
C
A
C
A
C
A
G
A
T
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33,291
G
G
C
C
A
A
G
G
C
C
A
G
G
G
T
T
G
C
C
T
G
C
G
G
G
A
G
C
C
A
G
G
T
G
T
C
C
G
C
T
C
T
C
C
A
C
A
C
C
T
T
T
C
A
C
A
G
G
T
A
A
C
T
G
A
C
0.019569
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0.021526
0.029354
0.021526
0.056751
0.07045
0.007828
0.013699
0.023483
0
33,292
C
C
G
G
A
G
T
T
G
A
G
T
C
G
G
A
G
T
G
G
C
G
A
G
C
T
G
G
T
A
A
G
T
G
G
C
C
A
G
G
G
G
T
C
C
A
G
G
A
G
A
G
C
C
T
G
C
A
T
C
A
G
G
G
A
C
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0.02544
0
33,293
G
C
T
C
C
A
G
A
G
C
T
T
G
G
C
G
G
C
G
A
A
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C
A
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A
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A
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T
G
C
G
T
C
C
G
C
A
T
C
A
C
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0
33,294
C
A
A
G
G
C
C
A
A
C
A
G
C
G
A
G
T
C
C
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C
T
C
T
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G
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G
C
C
C
T
C
T
G
A
T
G
T
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0
33,295
T
C
C
T
G
G
G
A
A
T
G
A
G
A
G
C
A
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A
C
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C
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A
C
C
C
T
A
A
G
T
C
C
A
A
C
T
C
T
T
C
C
A
C
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0
0.003914
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0.052838
0.023483
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0
33,296
G
C
C
C
C
G
C
T
G
C
T
G
G
G
A
C
C
C
C
C
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C
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C
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G
C
A
A
T
C
C
G
G
C
G
A
C
G
G
C
G
G
T
C
C
0.011742
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0
0.011742
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0.04501
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0.001957
0.007828
0
33,297
C
G
G
G
C
A
C
C
G
T
C
G
C
C
G
C
G
G
G
G
A
C
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G
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C
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C
C
A
C
C
T
C
G
C
T
C
A
T
C
C
C
G
C
C
G
A
0.001957
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0
0.005871
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0.011742
0
0.005871
0
33,298
G
A
C
T
C
C
T
G
C
G
T
C
A
A
T
T
C
T
G
A
G
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T
T
C
C
C
C
A
G
T
T
C
T
A
G
C
T
T
T
C
C
G
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0.072407
0.019569
0.031311
0.019569
0.048924
0.005871
0.019569
0.046967
0
33,299
T
C
T
A
G
G
T
T
C
C
G
G
C
C
A
T
A
G
T
T
C
A
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C
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G
A
G
C
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G
C
C
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C
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C
C
T
C
A
C
T
T
C
A
C
A
G
C
T
G
G
A
T
A
C
G
0.005871
0.015656
0.021526
0.001957
0.027397
0.041096
0.021526
0.019569
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0.060665
0.054795
0.009785
0.001957
0.027397
0
33,300
C
G
T
G
C
T
A
C
C
C
C
C
T
G
A
G
C
C
A
G
G
C
T
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G
C
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C
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C
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C
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C
A
C
A
C
C
T
C
C
C
C
T
C
G
A
G
C
C
C
T
A
0.003914
0.011742
0.02544
0.009785
0.031311
0.039139
0.017613
0.019569
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0.019569
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0.046967
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0.029354
0.035225
0.054795
0.04501
0.007828
0.001957
0.029354
0
33,301
C
T
G
G
G
G
G
G
T
G
G
G
G
T
G
G
G
T
G
T
A
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C
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C
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C
G
C
T
T
C
A
G
C
C
T
C
C
C
T
C
A
T
C
T
T
0.029354
0.019569
0.019569
0.02544
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0.07045
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0.02544
0.021526
0.039139
0.076321
0.033268
0.015656
0.017613
0.021526
0
33,302
C
T
G
G
T
G
G
G
T
G
A
C
C
C
C
A
T
G
C
A
C
A
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C
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C
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C
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A
C
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A
A
G
C
C
T
C
A
C
T
C
A
G
G
C
C
C
C
T
G
T
0.019569
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0.027397
0.009785
0.023483
0.039139
0.001957
0.021526
0.043053
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0.066536
0.021526
0.021526
0.039139
0.060665
0.054795
0.011742
0.009785
0.031311
0
33,303
C
T
C
C
T
C
A
C
A
C
C
A
T
G
G
T
G
G
C
C
T
C
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A
C
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G
G
T
G
A
C
G
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C
C
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A
G
C
G
C
C
T
C
C
T
C
G
C
T
T
C
T
C
A
A
T
0.013699
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0.011742
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0.058708
0.023483
0.02544
0.033268
0.07045
0.050881
0.015656
0.005871
0.029354
0
33,304
G
G
G
T
C
A
G
T
T
C
C
C
G
A
A
G
C
C
G
C
C
G
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C
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C
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G
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C
A
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C
A
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C
A
C
T
A
T
T
C
G
G
C
C
T
G
A
G
G
A
G
C
G
G
T
0.02544
0.011742
0.019569
0.013699
0.033268
0.039139
0.007828
0.013699
0.029354
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0.017613
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0.009785
0.029354
0.052838
0.029354
0.017613
0.027397
0.072407
0.050881
0.017613
0.005871
0.02544
0
33,305
T
A
G
T
C
C
A
C
A
A
T
C
A
T
C
A
C
T
G
A
C
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C
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C
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G
T
T
G
A
C
A
A
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A
A
C
G
A
T
G
A
G
G
C
T
0.009785
0.021526
0.02544
0.017613
0.027397
0.043053
0.011742
0.023483
0.035225
0.031311
0.04501
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0.039139
0.037182
0.048924
0.050881
0.074364
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0.011742
0.021526
0.039139
0.015656
0.017613
0.043053
0.062622
0.031311
0.015656
0.011742
0.031311
0
33,306
A
G
A
T
G
T
C
C
C
G
A
C
C
C
A
C
G
C
A
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T
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C
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A
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T
C
T
C
C
A
A
C
C
A
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C
A
C
A
G
T
A
G
C
G
0.019569
0.021526
0.033268
0.015656
0.037182
0.037182
0.009785
0.031311
0.035225
0.02544
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0.001957
0.02544
0.027397
0.031311
0.039139
0.062622
0.058708
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0.027397
0.015656
0.02544
0.015656
0.031311
0.035225
0.041096
0.035225
0.046967
0.052838
0.015656
0.001957
0.029354
0
33,307
T
G
A
C
C
T
G
A
G
G
G
G
C
T
T
C
T
C
C
C
C
C
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C
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C
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C
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T
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C
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G
T
C
C
C
C
G
T
G
C
A
G
A
C
T
C
C
C
T
G
T
0.013699
0.019569
0.035225
0.003914
0.029354
0.031311
0.021526
0.019569
0.039139
0.041096
0.052838
0.007828
0.019569
0.027397
0.031311
0.041096
0.060665
0.064579
0.082192
0.023483
0.007828
0.02544
0.003914
0.052838
0.019569
0.035225
0.04501
0.048924
0.058708
0.007828
0.007828
0.021526
0
33,308
T
G
A
G
C
A
A
G
T
T
G
G
A
C
A
C
G
G
G
T
C
C
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C
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C
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A
G
A
C
T
A
A
G
A
C
C
C
C
A
G
A
C
T
G
T
A
0.009785
0.017613
0.029354
0.001957
0.033268
0.04501
0.017613
0.023483
0.029354
0.039139
0.056751
0.001957
0.011742
0.019569
0.027397
0.060665
0.062622
0.072407
0.105675
0.021526
0.005871
0.015656
0.005871
0.050881
0.013699
0.033268
0.041096
0.056751
0.048924
0.007828
0.007828
0.02544
0
33,309
A
T
C
A
A
G
A
G
G
C
A
C
C
C
A
G
C
A
A
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A
T
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T
C
A
G
A
A
T
G
T
G
A
T
G
A
G
A
A
G
0.027397
0.023483
0.029354
0.011742
0.041096
0.02544
0.009785
0.02544
0.035225
0.033268
0.058708
0.02544
0.031311
0.039139
0.031311
0.037182
0.056751
0.058708
0.054795
0.013699
0.007828
0.011742
0.027397
0.039139
0.02544
0.027397
0.033268
0.056751
0.048924
0.013699
0.007828
0.031311
0
33,310
G
C
A
C
G
G
A
G
C
T
A
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C
A
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C
C
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C
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C
C
G
C
C
T
C
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G
A
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C
C
G
C
G
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C
0.011742
0.005871
0.019569
0.005871
0.007828
0.035225
0.017613
0.017613
0.027397
0.054795
0.052838
0.007828
0.017613
0.011742
0.009785
0.029354
0.07045
0.056751
0.09002
0.054795
0.02544
0.058708
0.009785
0.052838
0.015656
0.039139
0.021526
0.088063
0.039139
0.003914
0.005871
0.035225
0
33,311
C
T
G
T
G
T
A
A
G
T
C
A
G
A
G
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C
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C
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C
C
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G
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G
G
T
G
G
C
C
C
0.001957
0.003914
0.019569
0.009785
0.023483
0.033268
0.015656
0.02544
0.027397
0.050881
0.062622
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0.015656
0.015656
0.013699
0.056751
0.072407
0.078278
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0.015656
0.003914
0.072407
0.013699
0.029354
0.029354
0.068493
0.064579
0.007828
0.005871
0.02544
0
33,312
A
G
C
C
A
T
A
T
G
A
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G
C
A
G
G
C
A
G
G
C
C
C
C
C
A
C
C
C
A
G
C
A
G
G
G
C
C
A
C
C
A
G
C
A
T
0.007828
0.017613
0.021526
0.005871
0.02544
0.039139
0.009785
0.021526
0.019569
0.050881
0.07045
0.007828
0.015656
0.02544
0.017613
0.039139
0.09002
0.066536
0.072407
0.019569
0.017613
0.027397
0.015656
0.035225
0.019569
0.023483
0.056751
0.080235
0.035225
0.015656
0.007828
0.021526
0
33,313
T
T
G
T
G
C
T
G
G
G
C
A
G
C
A
T
T
G
C
C
A
T
C
A
T
C
A
C
A
G
C
C
T
G
G
A
A
C
C
T
C
A
G
C
T
G
T
G
A
G
A
G
G
G
A
A
G
G
G
A
A
G
G
T
G
C
0.009785
0.017613
0.033268
0.007828
0.035225
0.043053
0.003914
0.033268
0.035225
0.027397
0.058708
0.021526
0.021526
0.027397
0.029354
0.056751
0.058708
0.068493
0.084149
0.011742
0.007828
0.007828
0.007828
0.054795
0.023483
0.033268
0.037182
0.039139
0.058708
0.007828
0.005871
0.031311
0
33,314
G
C
A
C
T
G
C
T
C
T
C
C
T
T
T
T
C
C
G
G
G
A
T
C
T
C
T
C
C
C
C
A
T
T
C
T
C
C
C
A
G
G
C
T
T
C
C
A
G
G
G
C
A
T
C
G
G
A
A
C
T
C
T
G
C
C
0.031311
0.027397
0.035225
0.015656
0.015656
0.039139
0.007828
0.019569
0.037182
0.043053
0.068493
0.003914
0.02544
0.021526
0.019569
0.041096
0.062622
0.048924
0.07045
0.019569
0.007828
0.015656
0.005871
0.066536
0.035225
0.009785
0.048924
0.037182
0.060665
0.003914
0.023483
0.031311
0
33,315
G
T
T
T
G
A
A
G
C
A
A
A
T
G
C
T
C
A
G
A
G
G
G
C
C
T
G
G
T
A
G
G
C
G
G
A
T
G
G
G
C
G
T
C
T
C
C
G
G
A
T
G
A
T
G
C
A
G
A
A
A
G
C
A
A
T
0.039139
0.019569
0.035225
0.017613
0.013699
0.043053
0.009785
0.021526
0.02544
0.031311
0.068493
0.013699
0.031311
0.031311
0.033268
0.035225
0.052838
0.050881
0.072407
0.021526
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0.011742
0.007828
0.048924
0.027397
0.019569
0.043053
0.046967
0.048924
0.013699
0.011742
0.04501
0
33,316
A
G
G
T
G
G
C
C
T
T
G
G
A
T
A
A
G
G
G
C
T
G
C
T
C
C
C
A
A
T
T
C
C
G
C
C
T
G
G
C
C
G
T
C
C
T
G
G
A
C
T
G
G
A
A
C
C
A
G
A
G
G
G
C
C
T
0.052838
0.023483
0.056751
0.013699
0.023483
0.027397
0.011742
0.02544
0.050881
0.033268
0.07045
0.013699
0.021526
0.013699
0.043053
0.027397
0.046967
0.048924
0.050881
0.009785
0.003914
0.005871
0.017613
0.058708
0.04501
0.029354
0.017613
0.041096
0.058708
0.007828
0.007828
0.041096
0
33,317
A
A
G
G
C
C
A
T
T
C
A
G
G
C
A
A
A
A
A
G
A
G
G
T
G
G
A
A
G
A
G
T
C
T
T
C
T
C
C
T
A
G
A
G
G
G
A
G
G
T
A
G
T
G
C
A
A
A
G
G
T
G
G
C
A
T
0.037182
0.023483
0.054795
0.037182
0.029354
0.027397
0.001957
0.033268
0.048924
0.029354
0.052838
0.015656
0.017613
0.033268
0.041096
0.041096
0.043053
0.052838
0.041096
0.003914
0.001957
0.003914
0.017613
0.048924
0.050881
0.011742
0.039139
0.041096
0.041096
0.015656
0.02544
0.037182
0
33,318
T
G
A
A
G
C
T
C
C
C
A
G
A
A
T
G
C
C
A
G
A
G
G
C
T
G
C
T
C
C
C
C
C
C
G
T
G
G
C
C
C
C
T
G
C
A
C
C
A
G
C
A
G
C
T
C
C
T
A
C
A
C
C
G
G
G
0.027397
0.021526
0.039139
0.017613
0.021526
0.033268
0.017613
0.017613
0.037182
0.043053
0.052838
0.005871
0.017613
0.02544
0.033268
0.017613
0.080235
0.060665
0.097847
0.021526
0.001957
0.001957
0.007828
0.02544
0.043053
0.041096
0.039139
0.048924
0.052838
0.011742
0.001957
0.035225
0
33,319
C
T
G
T
G
G
C
T
G
G
C
T
C
A
G
C
T
G
T
G
T
C
C
C
A
G
G
A
G
C
T
A
C
G
G
G
A
G
G
G
G
G
A
C
C
C
A
G
T
T
T
C
T
C
T
C
T
C
C
A
C
T
C
C
C
G
0.029354
0.029354
0.043053
0.009785
0.019569
0.021526
0.015656
0.035225
0.050881
0.048924
0.041096
0.007828
0.023483
0.017613
0.017613
0.02544
0.062622
0.052838
0.064579
0.029354
0.019569
0.013699
0.009785
0.058708
0.056751
0.027397
0.02544
0.029354
0.07045
0.009785
0.007828
0.02544
0
33,320
G
C
T
G
G
A
G
A
C
C
A
G
T
G
A
G
A
C
C
A
C
A
G
A
G
A
T
C
A
A
C
A
C
T
G
A
C
T
T
G
G
C
G
C
G
G
G
A
G
G
T
A
A
G
C
T
C
C
C
G
G
C
C
C
T
T
0
0.013699
0.015656
0.005871
0.021526
0.037182
0.011742
0.02544
0.02544
0.052838
0.052838
0.005871
0.031311
0.043053
0.017613
0.043053
0.074364
0.072407
0.080235
0.023483
0.009785
0.017613
0.009785
0.056751
0.011742
0.02544
0.046967
0.056751
0.054795
0.013699
0.005871
0.037182
0
33,321
A
C
A
A
G
C
C
T
G
G
A
A
G
A
G
A
T
T
T
T
C
A
A
T
T
G
C
A
T
C
T
T
T
G
A
T
G
C
C
C
A
T
G
T
T
C
C
T
C
C
G
C
T
C
T
G
G
G
G
A
A
A
G
G
C
G
0.027397
0.035225
0.039139
0.027397
0.031311
0.029354
0.005871
0.027397
0.066536
0.019569
0.060665
0.013699
0.035225
0.037182
0.037182
0.021526
0.052838
0.039139
0.041096
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0.003914
0.003914
0.021526
0.060665
0.039139
0.02544
0.033268
0.029354
0.04501
0.013699
0.02544
0.04501
0
33,322
G
C
T
C
A
A
A
C
T
G
C
T
C
C
A
C
A
C
G
C
A
T
G
G
C
C
A
A
G
T
C
C
C
G
G
G
T
C
C
A
G
G
C
A
G
C
C
A
A
T
G
G
C
T
T
T
T
G
T
G
A
G
G
G
G
T
0.031311
0.021526
0.031311
0.027397
0.037182
0.02544
0.015656
0.029354
0.031311
0.046967
0.043053
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0.02544
0.033268
0.052838
0.056751
0.054795
0.056751
0.019569
0.003914
0.011742
0.009785
0.050881
0.027397
0.015656
0.041096
0.052838
0.039139
0.017613
0.019569
0.035225
0
33,323
A
G
C
G
G
G
A
G
C
C
C
C
C
A
A
G
A
A
C
G
G
T
T
T
C
C
G
A
C
T
G
C
T
G
T
G
T
G
C
C
G
A
G
G
G
C
C
C
C
A
G
G
C
G
G
C
C
A
T
G
G
T
G
A
G
C
0.005871
0.013699
0.027397
0.005871
0.015656
0.050881
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0.017613
0.031311
0.046967
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0.001957
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0.04501
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0.062622
0.127202
0.041096
0.013699
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0.058708
0.017613
0.021526
0.04501
0.064579
0.046967
0.009785
0.005871
0.017613
0
33,324
C
C
C
C
C
T
G
T
C
C
C
C
G
C
C
T
C
T
T
A
C
G
C
C
C
C
C
C
A
C
C
A
C
C
C
C
C
T
G
C
C
T
G
G
T
T
G
A
A
G
G
G
T
C
C
G
G
C
C
T
G
C
C
G
G
T
0.009785
0.015656
0.029354
0.005871
0.019569
0.046967
0.003914
0.017613
0.033268
0.048924
0.054795
0.001957
0.013699
0.013699
0.02544
0.04501
0.058708
0.064579
0.129159
0.037182
0.011742
0.02544
0.009785
0.056751
0.019569
0.017613
0.043053
0.062622
0.046967
0.009785
0.005871
0.015656
0
33,325
T
G
C
A
C
A
G
T
A
T
C
G
C
C
T
G
G
T
C
G
G
C
T
T
G
G
G
C
C
T
G
A
C
G
C
C
T
C
T
T
C
T
C
C
C
A
C
A
G
T
T
C
C
T
G
C
G
C
T
C
C
C
A
G
G
T
0.007828
0.011742
0.021526
0.009785
0.023483
0.048924
0.017613
0.013699
0.023483
0.050881
0.050881
0.005871
0.017613
0.009785
0.019569
0.064579
0.062622
0.050881
0.062622
0.054795
0.019569
0.056751
0.017613
0.037182
0.021526
0.017613
0.058708
0.080235
0.027397
0.009785
0.001957
0.023483
0
33,326
T
G
T
T
G
C
A
G
T
C
G
G
C
G
T
C
A
G
A
G
C
A
G
C
T
C
C
A
G
T
G
C
T
G
G
G
G
T
T
A
G
C
A
C
G
G
G
C
T
C
T
G
G
T
T
C
T
G
G
G
A
C
T
G
A
C
0.011742
0.019569
0.02544
0.005871
0.017613
0.02544
0.009785
0.019569
0.04501
0.076321
0.043053
0
0.015656
0.009785
0.019569
0.023483
0.062622
0.031311
0.062622
0.052838
0.031311
0.066536
0.019569
0.076321
0.02544
0.02544
0.046967
0.052838
0.048924
0.005871
0.005871
0.017613
0
33,327
C
C
A
G
A
C
T
T
G
G
A
G
T
A
T
T
T
T
C
A
G
C
G
T
C
G
C
T
A
T
T
T
C
A
C
G
C
C
G
G
C
G
G
A
G
G
T
G
G
C
C
C
A
A
C
A
T
A
A
C
A
G
G
C
C
A
0.027397
0.027397
0.02544
0.013699
0.033268
0.031311
0.041096
0.02544
0.023483
0.031311
0.041096
0.021526
0.017613
0.017613
0.027397
0.046967
0.048924
0.050881
0.043053
0.041096
0.019569
0.039139
0.009785
0.037182
0.02544
0.031311
0.033268
0.060665
0.041096
0.02544
0.013699
0.027397
0
33,328
G
C
T
C
A
G
C
A
C
C
A
C
T
C
T
C
C
C
G
C
C
G
C
C
C
A
A
C
C
C
T
C
C
A
G
T
A
C
G
C
C
T
T
A
C
C
C
C
T
T
G
A
G
C
T
A
A
G
C
T
T
C
T
C
C
A
0.037182
0.021526
0.046967
0.015656
0.015656
0.021526
0.003914
0.037182
0.046967
0.066536
0.041096
0.015656
0.021526
0.021526
0.029354
0.031311
0.062622
0.058708
0.046967
0.011742
0.007828
0.015656
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0.062622
0.035225
0.011742
0.043053
0.039139
0.050881
0.013699
0.019569
0.027397
0
33,329
G
G
C
T
T
C
C
G
G
A
C
C
C
C
G
G
G
C
T
C
T
G
C
G
G
T
C
C
C
G
C
G
T
G
G
T
G
G
G
C
T
C
C
G
T
C
C
C
T
G
C
C
C
C
G
C
C
T
C
C
C
C
C
G
G
C
0.001957
0.015656
0.023483
0.003914
0.007828
0.037182
0.011742
0.009785
0.027397
0.052838
0.046967
0
0.005871
0.009785
0.009785
0.015656
0.056751
0.031311
0.131115
0.097847
0.02544
0.058708
0.009785
0.046967
0.027397
0.027397
0.041096
0.097847
0.043053
0.007828
0.005871
0.011742
0
33,330
C
C
A
G
G
G
G
C
C
C
A
G
G
A
C
C
C
C
C
A
C
C
G
T
G
A
A
C
A
C
G
G
C
G
G
A
G
A
G
G
G
C
G
G
G
G
G
G
C
T
G
C
A
G
C
A
G
A
A
G
C
A
G
G
A
A
0.001957
0.015656
0.015656
0.001957
0.009785
0.039139
0.019569
0.005871
0.021526
0.052838
0.046967
0
0.001957
0.003914
0.007828
0.021526
0.056751
0.029354
0.117417
0.111546
0.031311
0.068493
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0.048924
0.021526
0.031311
0.039139
0.109589
0.041096
0.005871
0.003914
0.011742
0
33,331
G
T
C
C
A
T
G
G
A
C
C
A
G
G
C
A
C
C
T
G
T
C
G
A
G
T
G
T
A
T
C
C
T
C
C
T
G
A
T
G
A
A
G
C
A
G
T
G
C
T
G
G
G
C
A
G
A
G
C
A
G
C
C
G
G
A
0.011742
0.015656
0.031311
0.005871
0.043053
0.035225
0
0.031311
0.033268
0.033268
0.074364
0.005871
0.013699
0.021526
0.021526
0.050881
0.082192
0.064579
0.078278
0.011742
0.013699
0.001957
0.007828
0.052838
0.027397
0.033268
0.043053
0.060665
0.054795
0.009785
0.003914
0.02544
0
33,332
G
G
T
C
T
A
G
G
T
A
G
G
T
G
T
A
G
G
G
C
A
G
C
A
C
C
A
G
G
C
C
C
T
G
G
T
T
C
C
G
C
T
C
C
T
G
G
A
T
G
C
C
C
C
T
C
G
A
G
A
T
C
T
G
G
C
0.033268
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0.019569
0.021526
0.029354
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0.048924
0.009785
0.007828
0.02544
0
33,333
T
C
A
T
C
T
G
G
G
C
C
T
G
T
G
T
T
C
C
C
C
T
G
G
G
A
T
T
T
A
G
A
T
G
G
A
G
A
C
G
C
T
G
T
T
C
T
C
G
A
T
G
A
G
G
G
G
A
G
G
G
T
C
T
A
C
0.041096
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0.027397
0
33,334
A
T
C
C
C
C
T
C
A
T
T
T
C
C
C
A
A
C
T
A
T
C
A
C
C
T
C
T
A
G
G
A
C
G
G
C
A
G
A
G
G
T
G
G
A
A
T
C
A
G
G
G
A
T
G
G
T
G
A
A
G
A
G
G
G
T
0.017613
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0.037182
0
33,335
C
T
G
A
T
C
C
C
T
C
C
C
T
C
C
G
C
A
G
T
G
G
A
A
C
C
C
A
G
G
C
T
C
C
T
G
A
T
A
T
C
C
A
T
C
T
G
G
G
T
G
A
G
C
C
A
G
C
C
A
G
A
G
G
G
G
0.011742
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0.017613
0.039139
0.062622
0.064579
0.009785
0.007828
0.02544
0
33,336
T
G
G
A
G
A
G
T
C
C
G
G
G
C
G
G
T
G
A
G
G
A
G
G
A
C
T
C
G
G
G
G
C
G
A
G
G
G
C
G
G
G
C
A
A
G
G
A
T
G
G
A
G
A
A
G
G
G
G
A
G
T
G
C
G
G
0.003914
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0.060665
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0.054795
0.062622
0.060665
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0.003914
0.017613
0
33,337
G
C
A
T
T
A
T
G
C
A
A
C
C
C
G
C
C
T
C
C
C
C
G
C
C
C
G
C
C
C
G
G
T
G
G
A
G
C
T
T
C
C
A
C
T
C
G
G
C
T
G
C
G
G
G
C
T
G
G
A
G
C
G
G
C
C
0.003914
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0.017613
0.031311
0.052838
0.084149
0.050881
0.007828
0.007828
0.015656
0
33,338
G
G
T
G
G
A
C
C
T
A
A
A
G
T
T
C
C
C
C
G
C
T
T
C
C
G
T
G
C
C
C
A
T
G
G
G
A
G
C
C
C
A
G
G
A
C
C
T
C
A
T
C
T
C
C
A
A
A
C
T
G
C
T
C
A
C
0.023483
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0.050881
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0.015656
0.017613
0.027397
0
33,339
A
A
G
T
T
C
A
G
C
C
A
G
G
T
A
G
A
T
G
T
G
G
G
G
C
A
G
G
G
G
A
A
T
G
C
T
A
A
A
T
A
A
A
T
A
C
A
G
G
G
A
G
A
C
A
G
A
G
A
C
A
G
G
G
G
C
0.037182
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0.011742
0.023483
0.037182
0
33,340
A
A
G
T
A
G
G
A
C
A
C
T
C
A
C
A
G
C
G
G
G
G
C
C
A
G
G
A
G
C
T
A
T
G
A
G
T
C
G
G
T
A
C
A
C
C
T
G
T
C
C
C
G
G
G
T
G
C
A
A
G
A
A
C
T
C
0.041096
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0
33,341
A
T
G
T
T
C
G
T
C
C
C
T
C
T
G
G
C
C
A
T
G
A
G
G
G
G
G
C
A
G
C
C
C
C
T
G
G
A
C
A
C
A
C
T
C
G
G
A
G
G
A
A
A
C
T
G
C
A
A
G
G
G
A
A
A
T
0.023483
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0.021526
0.033268
0.048924
0.04501
0.048924
0.007828
0.017613
0.029354
0
33,342
C
C
T
C
C
C
A
G
G
T
T
A
C
A
A
T
C
T
G
C
C
C
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G
G
G
A
G
G
A
T
C
C
A
A
G
C
T
T
C
C
A
G
T
A
T
C
C
T
G
G
G
A
A
T
T
T
T
G
C
C
C
G
G
C
T
0.011742
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0
0.035225
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0.04501
0.056751
0.007828
0.007828
0.035225
0
33,343
A
A
A
T
G
G
C
C
A
G
G
G
G
G
A
T
G
C
C
C
C
C
C
C
G
A
C
A
C
C
C
C
T
G
C
C
A
A
C
C
C
C
T
G
T
G
G
A
C
C
T
G
G
A
G
C
T
C
G
A
A
T
G
G
G
C
0.023483
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0.048924
0.039139
0.054795
0.007828
0.001957
0.015656
0
33,344
C
C
G
C
T
C
C
A
C
T
G
C
T
G
A
G
C
G
C
A
A
A
C
T
C
C
T
G
C
C
A
C
T
C
C
T
C
A
A
G
C
C
T
C
C
C
A
A
A
C
C
A
A
C
T
C
G
T
G
T
C
A
G
G
C
C
0.017613
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0.050881
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0.054795
0.005871
0.003914
0.021526
0
33,345
G
C
C
A
G
G
A
C
T
C
C
C
G
A
C
T
C
C
A
G
C
C
C
C
A
G
C
A
G
G
G
A
T
G
G
T
T
A
C
T
A
T
A
A
A
A
A
C
T
G
C
A
A
C
T
C
T
C
T
T
C
A
G
C
A
C
0.039139
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0.033268
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0.066536
0.09002
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0
0.013699
0.062622
0.031311
0.019569
0.035225
0.031311
0.062622
0.013699
0.009785
0.02544
0
33,346
G
C
C
A
G
A
A
C
C
A
G
A
G
G
C
T
T
C
T
C
G
A
G
G
C
T
G
T
T
G
G
A
T
C
T
T
C
T
T
C
A
G
G
C
A
C
C
C
C
C
A
A
T
G
C
C
C
C
C
C
C
A
C
C
C
C
0.009785
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0.033268
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0.031311
0.060665
0.043053
0.009785
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0.039139
0
33,347
C
T
G
G
A
A
A
G
G
A
A
A
G
G
A
A
G
A
G
T
G
G
G
G
A
G
G
C
A
G
G
A
T
G
G
G
G
C
A
C
A
G
G
T
G
A
G
C
T
G
G
G
A
C
A
A
G
A
T
G
G
G
A
G
A
C
0.02544
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0.021526
0.039139
0.054795
0.011742
0.009785
0.039139
0
33,348
T
G
C
C
C
T
T
T
C
A
A
T
G
G
A
G
A
A
T
C
A
C
A
C
A
C
A
G
C
T
T
C
C
G
C
T
G
G
A
T
G
G
C
C
C
A
G
G
T
G
T
T
G
G
C
C
T
C
T
G
A
G
C
T
C
T
0.019569
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0.021526
0.043053
0.064579
0.013699
0.009785
0.029354
0
33,349
A
G
A
G
A
G
G
T
C
C
A
G
C
C
A
T
T
T
C
T
T
G
G
A
G
A
A
G
G
C
C
A
C
G
A
C
C
A
A
T
A
G
T
A
G
G
A
T
A
A
A
G
G
C
A
A
C
C
A
G
G
C
T
G
A
T
0.021526
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0.037182
0.02544
0.019569
0.054795
0.060665
0.013699
0.009785
0.023483
0
33,350
C
A
T
T
C
T
C
T
A
A
G
T
C
A
G
A
A
C
A
G
C
T
C
C
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G
A
T
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T
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A
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A
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T
G
C
A
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G
C
C
C
C
A
T
G
G
A
C
A
T
A
A
C
G
T
G
G
C
0.037182
0.019569
0.033268
0.02544
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0.009785
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0.019569
0.02544
0.060665
0.046967
0.015656
0.013699
0.029354
0
33,351
T
G
G
G
C
C
A
C
A
C
A
A
A
C
C
C
C
C
T
G
G
C
C
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C
C
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C
C
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C
C
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C
C
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G
G
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G
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C
C
A
C
C
T
C
C
A
G
G
C
C
A
G
G
C
C
A
G
G
T
0.003914
0.003914
0.011742
0.001957
0.02544
0.017613
0.019569
0.007828
0.027397
0.064579
0.062622
0
0.017613
0.023483
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0
0.019569
0
33,352
C
T
T
G
T
T
G
A
A
G
A
T
G
T
A
G
T
A
G
T
C
C
T
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C
A
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C
T
T
G
G
C
G
C
T
C
A
G
C
C
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C
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G
G
T
G
C
T
C
C
A
G
C
C
G
C
A
G
C
G
C
C
A
T
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0
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0.054795
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0
0.023483
0
33,353
T
G
T
T
T
C
A
G
C
G
C
A
G
A
A
T
G
G
A
A
A
C
C
C
T
G
A
A
C
C
T
G
C
G
C
T
G
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A
G
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A
C
T
G
G
G
C
G
T
T
A
A
G
G
A
A
G
C
C
C
A
A
T
0.02544
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0
33,354
T
C
T
C
C
A
T
C
A
G
T
A
T
C
T
C
C
T
G
G
C
T
A
T
G
G
T
C
A
T
A
G
C
G
T
A
T
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T
A
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C
C
G
T
G
C
C
G
G
C
C
T
C
T
T
C
T
C
G
T
G
G
C
T
0.04501
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0
33,355
G
G
T
G
G
T
C
A
G
C
A
C
C
C
T
G
G
C
C
T
T
A
C
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G
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G
A
G
C
A
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C
C
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C
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T
C
C
C
A
T
C
T
G
T
C
A
G
C
A
G
T
G
G
G
C
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0.037182
0
33,356
T
T
G
A
G
G
T
G
G
T
C
A
A
G
A
C
A
G
C
C
C
T
C
C
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C
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C
C
T
G
G
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A
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G
G
C
C
C
G
G
G
A
A
T
C
C
A
G
C
C
A
A
T
A
0.035225
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0
33,357
C
T
G
G
G
G
A
T
A
C
A
G
A
A
G
G
A
G
G
C
T
T
G
G
G
C
A
C
A
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G
G
T
C
G
C
A
C
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C
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A
A
T
G
C
A
G
G
G
G
G
C
C
C
A
G
G
A
G
C
T
G
0.041096
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0.007828
0.019569
0.031311
0
33,358
A
C
A
A
G
C
A
G
A
A
T
G
C
A
G
G
G
G
G
C
C
C
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G
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G
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C
A
C
A
T
C
T
T
C
A
T
T
T
T
C
A
T
T
C
G
T
0.04501
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0.027397
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0.007828
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0.033268
0
33,359
T
A
A
T
T
A
T
T
T
T
T
C
T
T
T
T
T
T
C
T
T
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C
A
G
A
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C
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T
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G
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T
G
C
C
C
T
T
T
C
C
T
C
T
A
T
C
A
T
A
A
G
T
0.119374
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0.04501
0.066536
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0.015656
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0.023483
0.017613
0.072407
0.037182
0
33,360
C
T
C
T
T
C
T
A
C
T
C
A
C
A
A
T
G
G
A
A
A
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C
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C
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A
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C
A
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C
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A
G
T
G
A
C
A
A
G
T
C
G
C
T
A
T
G
A
G
C
G
T
0.078278
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0.021526
0.031311
0.013699
0.02544
0.017613
0.046967
0.050881
0
33,361
A
T
G
T
G
G
G
G
C
T
C
T
G
G
C
A
G
T
C
C
T
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C
G
A
G
G
A
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C
C
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C
A
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G
G
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G
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A
G
G
T
G
A
G
C
A
A
A
G
C
C
T
G
T
A
G
A
T
T
T
0.017613
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0.037182
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0.04501
0.04501
0.011742
0.005871
0.048924
0
33,362
T
C
T
A
C
A
G
G
C
T
T
T
G
C
T
C
A
C
C
T
T
C
A
C
C
G
T
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G
A
G
G
C
T
C
T
C
C
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C
G
C
A
G
G
A
C
T
G
C
C
A
G
A
G
C
C
C
C
A
C
A
T
G
G
T
0.017613
0.019569
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0.039139
0.04501
0.04501
0.011742
0.005871
0.048924
0
33,363
C
C
G
G
C
T
G
G
T
C
C
T
G
G
C
A
C
A
G
T
G
G
C
T
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C
A
C
C
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C
C
C
G
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C
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G
G
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C
C
C
T
C
A
C
A
C
C
A
G
T
G
G
C
T
G
C
T
G
A
C
C
T
0.005871
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0.056751
0.058708
0.048924
0.009785
0
0.041096
0
33,364
C
T
G
A
G
A
A
C
A
G
T
T
T
T
A
G
T
T
G
T
C
C
T
T
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T
A
T
T
T
G
C
T
G
G
T
G
G
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C
T
G
T
G
G
T
A
A
A
A
G
G
C
A
A
C
A
G
G
A
A
T
C
T
A
C
0.064579
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0.033268
0.037182
0
0.031311
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0.007828
0.023483
0.015656
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0.021526
0.050881
0.029354
0
33,365
C
T
T
C
T
T
G
G
G
A
C
A
T
T
T
T
C
C
T
A
G
G
A
A
C
C
G
G
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A
G
T
C
C
T
T
C
C
C
C
A
G
G
A
C
A
C
A
G
G
C
T
C
T
G
C
A
G
C
C
T
G
A
G
T
T
0.02544
0.015656
0.039139
0.021526
0.041096
0.02544
0.001957
0.029354
0.043053
0.054795
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0.052838
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0.031311
0.029354
0.031311
0.043053
0.048924
0.013699
0.021526
0.027397
0
33,366
C
C
A
C
C
A
G
G
T
C
C
T
G
G
A
G
C
C
T
A
A
G
G
A
T
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T
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C
T
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T
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G
T
C
C
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C
C
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C
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G
C
C
T
G
C
A
A
A
C
A
G
A
G
T
A
C
A
C
G
T
C
0.029354
0.021526
0.04501
0.013699
0.041096
0.033268
0.007828
0.027397
0.031311
0.037182
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0.013699
0.015656
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0.033268
0.031311
0.068493
0.04501
0.050881
0.011742
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0.009785
0.009785
0.048924
0.029354
0.033268
0.033268
0.04501
0.054795
0.023483
0.015656
0.037182
0
33,367
T
C
C
C
A
G
G
A
A
T
C
C
A
T
T
A
T
G
G
A
T
C
T
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G
A
A
A
A
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A
C
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C
A
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C
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G
A
A
G
A
G
A
A
A
T
T
G
A
A
A
A
A
G
T
A
A
0.084149
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0.060665
0.033268
0.031311
0.013699
0.007828
0.029354
0.050881
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0.054795
0.015656
0.031311
0.033268
0.043053
0.017613
0.027397
0.029354
0
33,368
T
T
C
T
A
T
T
T
G
C
T
G
C
T
T
G
T
C
A
T
T
T
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C
T
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G
A
T
C
C
A
T
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A
T
G
G
A
T
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C
C
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G
G
A
C
A
T
T
T
T
C
A
G
A
T
C
T
C
C
T
T
C
0.080235
0.02544
0.064579
0.031311
0.031311
0.011742
0.007828
0.031311
0.052838
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0.023483
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0.054795
0.017613
0.035225
0.035225
0.041096
0.017613
0.027397
0.027397
0
33,369
C
A
C
G
G
G
T
T
T
T
C
T
T
T
T
T
A
C
C
T
C
A
G
A
T
A
G
C
A
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C
G
C
G
A
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A
A
G
G
T
G
C
T
A
A
G
A
A
A
A
A
G
G
G
C
T
C
T
T
C
T
T
T
0.072407
0.015656
0.04501
0.07045
0.031311
0.019569
0.011742
0.031311
0.052838
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0.019569
0.017613
0.02544
0.041096
0.062622
0.035225
0
33,370
G
A
C
T
T
G
G
G
A
C
T
C
A
G
C
A
A
T
G
T
C
A
G
C
C
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G
T
T
C
C
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G
G
C
C
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C
C
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C
C
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G
C
T
C
G
T
G
C
T
G
G
A
G
C
T
T
G
C
G
G
A
C
0.062622
0.02544
0.048924
0.062622
0.041096
0.015656
0.007828
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0.048924
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0.027397
0.011742
0.009785
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0.013699
0.046967
0.050881
0.027397
0.029354
0.017613
0.043053
0.009785
0.037182
0.052838
0
33,371
C
T
G
C
T
T
G
A
C
C
C
G
C
T
G
A
A
G
G
C
T
G
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C
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C
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C
C
A
C
A
C
T
A
T
C
T
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C
G
T
G
C
T
T
C
T
T
0.039139
0.015656
0.058708
0.031311
0.02544
0.015656
0.005871
0.027397
0.054795
0.066536
0.031311
0.019569
0.02544
0.027397
0.037182
0.02544
0.052838
0.039139
0.029354
0.021526
0.007828
0.015656
0.015656
0.052838
0.04501
0.021526
0.037182
0.037182
0.041096
0.011742
0.023483
0.041096
0
33,372
A
C
C
T
G
T
A
A
T
T
C
T
T
T
G
A
T
C
T
T
C
T
T
T
T
G
T
A
G
C
T
G
T
A
T
T
G
C
A
A
G
G
G
C
T
T
G
T
T
C
A
T
C
T
T
C
A
A
T
C
T
T
G
C
C
C
0.066536
0.023483
0.052838
0.056751
0.043053
0.017613
0
0.023483
0.052838
0.039139
0.035225
0.039139
0.029354
0.035225
0.041096
0.019569
0.037182
0.023483
0.019569
0.015656
0.003914
0.007828
0.015656
0.04501
0.039139
0.013699
0.02544
0.029354
0.029354
0.02544
0.052838
0.041096
0
33,373
C
A
G
G
G
G
G
T
C
C
T
T
G
T
T
T
T
T
G
T
C
C
A
G
C
C
A
G
C
C
G
G
C
G
A
T
G
T
T
G
T
A
G
T
C
C
A
C
G
G
T
G
C
C
G
G
C
A
T
A
G
T
G
C
A
T
0.048924
0.035225
0.048924
0.029354
0.060665
0.015656
0.001957
0.035225
0.046967
0.031311
0.037182
0.029354
0.017613
0.046967
0.046967
0.033268
0.046967
0.039139
0.02544
0.009785
0.001957
0.001957
0.023483
0.031311
0.043053
0.023483
0.037182
0.039139
0.031311
0.021526
0.023483
0.035225
0
33,374
G
T
T
T
C
A
T
G
A
T
C
T
G
A
T
A
G
G
T
C
T
T
G
T
G
C
A
A
G
G
A
C
C
T
C
A
G
C
A
C
C
T
G
T
G
A
C
T
T
G
C
C
G
G
T
A
C
C
A
G
C
G
C
C
A
T
0.021526
0.017613
0.029354
0.027397
0.033268
0.039139
0.003914
0.027397
0.048924
0.039139
0.048924
0.011742
0.033268
0.029354
0.039139
0.037182
0.074364
0.054795
0.035225
0.015656
0
0.015656
0.009785
0.050881
0.031311
0.039139
0.037182
0.029354
0.050881
0.009785
0.003914
0.054795
0
33,375
T
C
T
T
A
C
C
A
T
C
C
T
T
C
C
A
T
T
C
T
C
C
T
G
T
G
G
C
T
G
G
A
T
T
G
A
T
G
A
T
G
C
C
A
A
A
G
A
G
C
T
C
A
T
C
A
T
T
T
G
T
G
A
C
T
C
0.043053
0.017613
0.035225
0.027397
0.02544
0.033268
0.003914
0.027397
0.04501
0.043053
0.050881
0.007828
0.029354
0.021526
0.041096
0.033268
0.072407
0.058708
0.035225
0.015656
0
0.015656
0.009785
0.050881
0.035225
0.031311
0.041096
0.033268
0.058708
0.009785
0.003914
0.043053
0