row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_36_ref__4
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
33,376
A
C
C
T
G
C
A
A
G
G
G
C
A
T
C
T
C
G
G
G
G
T
C
A
A
A
T
T
C
G
A
A
C
T
G
G
G
G
G
A
C
G
A
G
C
T
T
G
G
A
C
C
A
A
G
G
C
T
C
G
A
A
T
T
T
G
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G
C
A
A
A
A
A
A
C
A
G
C
A
A
C
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C
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A
A
A
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A
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A
A
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A
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A
C
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C
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C
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C
C
C
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A
C
A
G
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C
A
T
T
C
T
A
C
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0
33,378
C
T
C
C
G
T
C
T
C
C
C
G
A
G
A
A
C
A
C
A
T
C
T
C
C
A
G
A
G
T
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T
C
C
T
G
A
A
A
T
G
A
G
A
G
T
G
T
C
G
C
T
T
T
T
A
A
G
G
T
T
C
G
C
A
T
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0
33,379
C
T
G
T
T
C
T
T
C
T
T
C
G
T
C
A
T
G
T
C
A
C
A
T
T
G
C
A
G
G
G
C
C
A
T
C
T
G
G
T
C
C
A
G
T
G
G
C
C
A
C
T
C
A
T
T
C
T
T
G
C
G
A
G
C
T
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0
33,380
A
G
G
A
G
C
T
C
A
G
A
A
A
G
G
T
C
C
A
T
G
G
A
A
A
A
T
A
A
G
A
T
C
C
A
G
G
T
C
T
G
C
A
G
A
T
A
C
A
C
C
G
T
G
C
C
C
T
C
A
A
A
T
A
C
T
0.117417
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0
33,381
T
A
C
T
T
G
C
T
G
G
T
T
G
T
G
G
C
T
T
C
T
G
T
T
C
A
G
C
T
G
T
G
T
G
A
C
A
T
A
C
T
A
A
A
C
A
A
A
A
A
A
G
C
A
C
A
C
A
T
T
A
C
T
A
T
A
0.091977
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0.041096
0
33,382
A
C
A
A
A
G
T
A
C
C
T
G
T
G
A
G
T
T
T
G
A
T
T
T
T
G
G
A
T
A
G
T
C
G
A
G
C
C
A
A
A
A
T
T
C
C
T
G
G
C
A
A
A
T
C
A
T
A
C
A
C
T
T
G
C
T
0.109589
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0
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0.031311
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0.04501
0
33,383
G
G
G
C
T
A
G
C
T
C
T
T
T
T
T
T
C
T
T
T
G
T
C
T
G
C
T
T
T
C
T
G
T
T
T
T
C
C
C
T
T
C
C
T
C
C
C
T
T
C
C
C
T
A
T
G
T
A
C
G
C
T
C
A
G
G
0.058708
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0.043053
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0.017613
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0.027397
0.035225
0
33,384
G
T
A
A
G
T
T
G
T
G
G
A
T
G
G
T
A
A
A
G
T
C
C
A
T
G
T
G
G
A
A
G
C
G
G
G
G
T
G
C
A
T
C
C
A
A
G
T
C
T
G
C
G
G
A
A
T
G
A
T
T
A
G
T
T
T
0.017613
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0.050881
0.017613
0.039139
0.029354
0.001957
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0.019569
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0.062622
0.054795
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0.005871
0.013699
0.039139
0.050881
0.023483
0.031311
0.037182
0.048924
0.017613
0.019569
0.033268
0
33,385
A
G
T
A
C
C
A
T
G
A
T
T
G
C
C
T
C
C
C
C
A
A
C
A
G
A
A
G
C
C
A
T
C
C
T
G
T
A
A
G
A
A
T
T
T
A
T
C
A
A
T
T
A
T
C
A
C
C
G
A
C
T
G
A
A
T
0.064579
0.019569
0.048924
0.056751
0.019569
0.023483
0.007828
0.033268
0.043053
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0.011742
0.060665
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0.003914
0
0.019569
0.023483
0.048924
0.023483
0.041096
0.037182
0.029354
0.029354
0.039139
0.037182
0
33,386
G
G
G
C
G
T
A
A
G
T
T
G
T
C
G
T
T
A
A
A
G
T
A
C
A
A
C
C
T
A
C
A
C
G
T
T
C
C
A
T
G
A
T
G
C
C
A
A
A
A
C
A
C
T
A
T
T
T
G
T
A
A
A
T
C
T
0.074364
0.037182
0.035225
0.039139
0.054795
0.031311
0.011742
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0.04501
0.019569
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0.041096
0.043053
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0.007828
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0.007828
0.02544
0.027397
0.029354
0.021526
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0.027397
0.027397
0.035225
0.039139
0.027397
0
33,387
C
C
T
A
C
C
A
T
G
A
T
C
C
C
A
G
A
A
C
C
C
A
C
A
C
A
C
T
T
A
C
A
T
G
C
G
G
A
T
T
C
C
A
G
A
G
A
C
T
G
T
C
C
A
A
C
T
G
A
A
A
A
C
T
A
G
0.046967
0.033268
0.050881
0.02544
0.035225
0.017613
0.013699
0.033268
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0.023483
0.048924
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0.009785
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0.017613
0.017613
0.035225
0.048924
0.027397
0.037182
0.027397
0.041096
0.015656
0.023483
0.041096
0
33,388
C
G
G
C
T
T
T
G
G
G
C
C
T
G
G
A
G
G
G
G
A
G
G
T
G
G
G
G
A
G
A
G
T
C
C
C
A
A
T
A
G
C
A
G
A
G
G
A
A
C
T
G
G
T
G
A
G
C
C
C
G
G
G
C
C
G
0.037182
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0.035225
0.019569
0.013699
0.011742
0.015656
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0.101761
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0.019569
0.017613
0.031311
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0.046967
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0.009785
0.125245
0.046967
0.007828
0.021526
0.043053
0.066536
0.005871
0.017613
0.017613
0
33,389
G
A
A
A
G
C
A
G
T
T
T
T
T
A
A
G
A
C
A
A
G
T
A
A
G
T
G
T
T
T
T
C
T
G
G
A
T
G
T
G
A
T
C
A
G
T
G
A
C
T
A
A
T
G
C
A
A
T
T
A
T
T
T
C
T
C
0.09589
0.041096
0.052838
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0.041096
0.02544
0.003914
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0
0.007828
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0.039139
0.019569
0.029354
0.017613
0.021526
0.023483
0.072407
0.039139
0
33,390
T
T
G
C
A
T
T
A
G
T
C
A
C
T
G
A
T
C
A
C
A
T
C
C
A
G
A
A
A
A
C
A
C
T
T
A
C
T
T
G
T
C
T
T
A
A
A
A
A
C
T
G
C
T
T
T
C
C
A
A
A
A
T
A
T
G
0.093933
0.037182
0.054795
0.052838
0.039139
0.02544
0.003914
0.037182
0.035225
0.023483
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0
0.007828
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0.039139
0.019569
0.031311
0.019569
0.021526
0.023483
0.072407
0.039139
0
33,391
A
T
T
G
G
C
T
T
T
T
A
T
C
A
C
C
T
T
C
A
T
A
C
A
G
T
T
C
C
C
A
T
T
G
A
A
G
A
A
A
T
T
G
T
A
A
A
T
T
C
G
G
A
T
C
T
T
G
C
C
A
T
C
T
G
G
0.086106
0.02544
0.02544
0.037182
0.04501
0.029354
0.003914
0.023483
0.039139
0.02544
0.050881
0.013699
0.029354
0.02544
0.046967
0.04501
0.052838
0.048924
0.033268
0.007828
0.007828
0.007828
0.011742
0.048924
0.029354
0.015656
0.043053
0.035225
0.043053
0.017613
0.011742
0.033268
0
33,392
G
T
G
C
A
G
A
T
G
G
C
A
A
G
A
T
C
C
G
A
A
T
T
T
A
C
A
A
T
T
T
C
T
T
C
A
A
T
G
G
G
A
A
C
T
G
T
A
T
G
A
A
G
G
T
G
A
T
A
A
A
A
G
C
C
C
0.086106
0.02544
0.02544
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0.039139
0.037182
0.043053
0.017613
0.011742
0.033268
0
33,393
T
G
G
G
A
C
C
T
A
C
A
A
T
G
T
T
C
G
C
A
T
T
C
T
C
T
C
T
G
A
C
A
C
G
T
A
G
G
T
A
C
T
G
G
G
G
T
C
A
G
A
A
T
C
T
G
G
G
T
C
T
C
T
A
G
T
0.04501
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0
0.005871
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0.041096
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0.039139
0.015656
0.041096
0.031311
0.019569
0.037182
0
33,394
C
G
T
T
T
C
C
T
C
G
T
T
C
T
G
G
T
A
T
G
C
A
G
T
C
C
A
C
A
G
G
T
T
G
T
A
C
T
C
A
T
T
C
T
A
A
C
A
A
G
G
G
A
A
T
A
T
T
T
G
A
A
G
T
T
C
0.039139
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0.033268
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0.023483
0.054795
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0.052838
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0.029354
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0.041096
0
0.005871
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0.048924
0.02544
0.031311
0.017613
0.041096
0.027397
0.019569
0.043053
0
33,395
G
G
G
A
T
A
T
G
G
C
T
C
C
T
G
G
A
G
T
C
T
A
G
G
G
A
G
C
A
G
T
C
C
C
C
A
C
C
A
A
G
G
A
C
G
G
T
G
C
T
G
G
C
T
T
C
T
C
G
G
G
T
T
C
C
A
0.07045
0.019569
0.031311
0.023483
0.019569
0.027397
0.009785
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0.052838
0.043053
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0.021526
0.054795
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0.021526
0.009785
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0.023483
0.046967
0.041096
0.02544
0.037182
0.033268
0.050881
0.017613
0.005871
0.027397
0
33,396
C
T
G
C
A
G
G
A
G
G
A
G
A
A
C
C
G
C
A
A
G
G
T
C
A
C
C
A
A
C
A
C
C
A
C
G
C
C
C
T
G
G
G
A
G
C
A
T
C
C
C
T
A
C
C
C
G
G
A
C
C
T
C
C
C
T
0.035225
0.035225
0.021526
0.015656
0.043053
0.041096
0.011742
0.021526
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0.033268
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0.027397
0.050881
0.029354
0.056751
0.019569
0.005871
0.033268
0
33,397
G
G
G
C
A
G
T
A
T
C
G
C
C
A
G
T
T
G
T
G
G
T
C
C
T
T
C
A
C
T
G
G
C
T
C
G
G
T
C
A
G
C
A
G
G
T
G
G
C
T
T
T
G
C
A
G
T
T
T
G
A
T
G
T
T
A
0.007828
0.011742
0.033268
0.007828
0.031311
0.031311
0.007828
0.041096
0.033268
0.048924
0.054795
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0.023483
0.02544
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0.058708
0.09589
0.060665
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0.011742
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0.011742
0.037182
0.029354
0.035225
0.07045
0.046967
0.048924
0.005871
0.003914
0.035225
0
33,398
G
A
A
T
A
G
G
G
C
T
T
C
C
A
G
T
T
T
C
C
A
A
A
C
C
T
G
A
G
A
G
C
T
A
C
A
A
C
T
T
G
G
A
G
A
A
T
G
G
A
A
A
A
G
A
A
C
C
A
T
T
G
A
A
G
C
0.138943
0.023483
0.062622
0.066536
0.023483
0.007828
0
0.037182
0.048924
0.035225
0.019569
0.050881
0.017613
0.029354
0.027397
0.017613
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0
0.019569
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0.062622
0.011742
0.015656
0.019569
0.029354
0.015656
0.062622
0.035225
0
33,399
A
G
G
C
T
C
T
T
A
C
C
T
T
C
A
C
C
T
C
C
A
G
G
G
C
A
C
T
G
A
C
G
T
G
G
G
G
C
A
G
C
T
C
C
A
T
C
T
C
A
C
T
G
T
A
A
G
G
C
A
A
C
C
C
A
C
0.011742
0.013699
0.04501
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0.023483
0.041096
0.009785
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0.078278
0
0.011742
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0.082192
0.072407
0.084149
0.009785
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0.046967
0.027397
0.033268
0.037182
0.068493
0.050881
0.007828
0.007828
0.031311
0
33,400
C
A
T
C
C
T
C
C
T
C
C
T
G
T
G
T
C
T
G
C
C
A
G
A
G
G
A
A
G
A
T
G
C
T
T
T
C
T
G
G
G
C
G
C
T
T
A
C
C
C
A
G
T
T
G
C
T
C
G
C
T
G
G
T
G
T
0.011742
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0.064579
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0.011742
0.043053
0.046967
0.056751
0.056751
0.011742
0.007828
0.037182
0
33,401
T
G
T
G
C
A
G
C
A
C
C
T
G
C
T
C
C
T
G
G
T
G
C
G
A
T
A
G
G
A
G
C
C
T
C
T
C
G
A
G
C
C
A
G
G
C
A
G
T
A
T
T
T
G
G
G
C
T
G
T
A
G
A
A
T
T
0.017613
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0.011742
0.013699
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0.007828
0.013699
0.021526
0.046967
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0.076321
0.093933
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0.054795
0.015656
0.029354
0.039139
0.076321
0.056751
0.007828
0.001957
0.031311
0
33,402
T
T
T
C
C
T
G
C
A
T
G
A
A
A
G
C
A
G
C
A
C
A
T
G
T
T
G
T
T
C
T
C
T
C
G
G
C
C
T
G
G
T
A
T
G
T
T
C
T
A
C
T
T
T
T
C
A
A
A
T
T
T
C
T
C
C
0.060665
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0.041096
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0.02544
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0.035225
0.052838
0.019569
0.031311
0.039139
0.033268
0.027397
0.021526
0.039139
0
33,403
T
C
C
G
G
G
C
C
C
T
G
C
G
C
C
C
G
G
C
C
G
A
G
C
G
C
G
G
T
A
G
C
C
T
T
T
G
T
G
A
G
C
G
G
G
G
T
C
T
T
G
G
C
G
T
T
G
C
T
G
C
G
C
A
T
A
0.029354
0.013699
0.019569
0.019569
0.007828
0.021526
0.015656
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0.027397
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0.017613
0.039139
0.02544
0.066536
0.076321
0.033268
0.066536
0.009785
0.066536
0.017613
0.017613
0.043053
0.091977
0.043053
0.009785
0.013699
0.023483
0
33,404
G
T
G
G
G
A
G
A
G
A
T
T
T
C
T
C
A
T
T
A
G
G
T
G
T
G
C
C
T
T
C
T
T
G
G
T
G
G
T
G
T
C
T
G
A
T
A
T
G
T
T
T
C
A
A
C
A
T
T
G
G
G
C
C
C
C
0.031311
0.02544
0.039139
0.037182
0.039139
0.033268
0.003914
0.02544
0.064579
0.037182
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0.011742
0.029354
0.029354
0.031311
0.031311
0.068493
0.052838
0.054795
0.003914
0.001957
0.009785
0.027397
0.029354
0.046967
0.029354
0.027397
0.035225
0.02544
0.015656
0.023483
0.041096
0
33,405
G
T
G
A
G
G
C
C
T
G
T
G
A
A
G
C
C
C
A
G
C
T
C
C
A
C
G
C
T
G
T
C
T
A
C
C
T
G
C
T
C
C
C
C
A
C
A
G
C
G
C
T
G
T
A
G
G
T
A
G
C
T
G
G
T
C
0.015656
0.015656
0.033268
0.007828
0.041096
0.029354
0.019569
0.019569
0.015656
0.064579
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0.017613
0.031311
0.04501
0.076321
0.046967
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0.015656
0.02544
0.011742
0.037182
0.021526
0.041096
0.050881
0.054795
0.052838
0.007828
0.005871
0.031311
0
33,406
T
T
T
C
A
T
C
A
G
T
G
T
G
A
A
T
T
T
T
C
C
A
G
A
A
G
C
C
A
C
C
T
T
T
T
C
C
T
C
G
C
C
T
C
T
C
T
A
G
T
C
T
A
T
C
A
T
C
G
T
A
G
T
C
A
G
0.097847
0.027397
0.04501
0.058708
0.035225
0.019569
0.001957
0.031311
0.054795
0.011742
0.031311
0.074364
0.029354
0.052838
0.035225
0.013699
0.027397
0.029354
0.011742
0
0.003914
0.001957
0.029354
0.027397
0.062622
0.019569
0.011742
0.013699
0.027397
0.027397
0.033268
0.052838
0
33,407
A
A
A
T
C
T
T
C
A
G
A
A
A
T
A
G
C
C
T
T
T
G
T
T
C
G
T
G
T
A
G
C
C
T
T
C
T
T
G
G
T
T
G
C
A
G
G
T
T
T
G
G
G
C
T
C
C
A
T
G
T
C
T
G
G
A
0.086106
0.027397
0.052838
0.072407
0.023483
0.017613
0.003914
0.031311
0.054795
0.027397
0.031311
0.039139
0.02544
0.031311
0.041096
0.019569
0.031311
0.041096
0.021526
0.001957
0.001957
0
0.031311
0.029354
0.064579
0.013699
0.019569
0.021526
0.035225
0.015656
0.046967
0.039139
0
33,408
G
G
A
G
G
C
C
C
C
G
A
T
C
T
G
T
C
C
C
A
G
C
C
A
A
G
G
C
C
T
C
C
C
G
G
C
G
C
C
A
T
C
A
C
C
C
A
C
C
A
G
G
A
G
T
C
C
C
G
G
G
C
G
G
G
T
0.017613
0.005871
0.021526
0.007828
0.013699
0.029354
0.009785
0.011742
0.015656
0.050881
0.048924
0
0.023483
0.011742
0.019569
0.029354
0.062622
0.060665
0.097847
0.074364
0.017613
0.078278
0.003914
0.039139
0.015656
0.027397
0.035225
0.093933
0.058708
0.001957
0.001957
0.013699
0
33,409
G
A
G
A
A
T
G
G
C
T
T
C
G
T
T
T
A
A
T
T
T
T
T
C
T
T
C
T
A
T
C
T
C
C
T
T
C
C
T
T
G
C
T
C
T
T
T
C
T
T
C
A
A
T
C
A
A
C
A
G
T
T
T
A
T
T
0.078278
0.037182
0.064579
0.064579
0.04501
0.019569
0.009785
0.023483
0.068493
0.02544
0.021526
0.050881
0.021526
0.043053
0.041096
0.017613
0.031311
0.023483
0
0
0.007828
0.001957
0.023483
0.019569
0.084149
0.007828
0.029354
0.003914
0.021526
0.035225
0.043053
0.035225
0
33,410
G
A
A
T
T
G
T
G
G
A
G
T
C
C
A
C
C
G
T
C
C
T
C
C
A
C
C
T
G
A
G
A
C
G
A
G
C
A
C
A
G
G
G
T
C
T
C
C
A
C
G
A
G
G
A
C
A
G
A
G
G
C
T
G
C
T
0.031311
0.019569
0.043053
0.02544
0.027397
0.037182
0.013699
0.019569
0.056751
0.035225
0.062622
0.009785
0.02544
0.017613
0.039139
0.02544
0.060665
0.062622
0.056751
0.003914
0.007828
0.001957
0.019569
0.050881
0.046967
0.046967
0.019569
0.021526
0.07045
0.005871
0.001957
0.033268
0
33,411
C
A
C
G
C
A
G
G
A
G
A
G
C
G
C
A
G
T
C
A
C
G
C
C
T
G
G
G
A
C
C
C
C
C
G
A
C
C
C
C
A
C
T
T
G
T
G
C
T
G
G
A
A
G
G
T
G
G
G
G
G
T
G
C
C
T
0.007828
0.003914
0.019569
0.005871
0.031311
0.031311
0.013699
0.017613
0.062622
0.027397
0.074364
0.005871
0.015656
0.015656
0.009785
0.062622
0.066536
0.054795
0.101761
0.013699
0.009785
0.02544
0.009785
0.086106
0.015656
0.023483
0.052838
0.058708
0.052838
0.003914
0.003914
0.015656
0
33,412
A
G
A
A
C
A
T
T
C
G
T
G
C
A
T
C
A
T
A
T
A
T
G
T
G
A
G
C
T
C
C
A
C
G
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T
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T
T
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A
A
G
G
G
G
G
T
G
G
G
T
G
T
T
T
T
G
C
T
G
C
T
0.041096
0.021526
0.035225
0.029354
0.039139
0.033268
0.009785
0.015656
0.027397
0.048924
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0.039139
0.019569
0.041096
0.031311
0.037182
0.052838
0.046967
0.064579
0.007828
0.003914
0.009785
0.017613
0.035225
0.035225
0.017613
0.039139
0.031311
0.039139
0.021526
0.021526
0.037182
0
33,413
G
G
C
T
G
G
C
C
A
C
A
T
C
C
A
G
G
G
A
G
C
T
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A
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C
T
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C
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C
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A
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T
T
G
G
T
G
G
G
G
G
A
G
T
C
G
A
G
G
A
C
C
T
T
0.013699
0.011742
0.031311
0.003914
0.015656
0.031311
0.011742
0.023483
0.046967
0.052838
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0.017613
0.017613
0.027397
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0.07045
0.074364
0.033268
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0.068493
0.023483
0.031311
0.033268
0.072407
0.058708
0.011742
0.005871
0.011742
0
33,414
G
C
A
C
A
T
G
G
A
G
A
C
C
A
A
T
G
C
A
G
T
G
G
G
G
C
C
C
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C
A
C
C
A
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C
C
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G
C
G
A
C
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A
C
G
C
C
A
G
G
G
C
C
G
C
A
G
C
G
A
G
A
A
0.005871
0.007828
0.02544
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0.02544
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0.015656
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0.07045
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0.013699
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0.009785
0.078278
0.019569
0.027397
0.060665
0.068493
0.041096
0
0
0.043053
0
33,415
C
T
C
G
C
C
C
C
G
A
G
C
C
C
C
A
G
A
C
A
C
C
G
C
C
C
C
T
G
C
G
C
C
G
G
T
G
A
C
C
T
T
G
G
A
C
G
G
T
C
A
G
C
G
C
C
C
C
A
G
C
C
T
C
G
G
0.039139
0.017613
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0.027397
0.019569
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0.023483
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0.029354
0.023483
0.078278
0.037182
0.011742
0.017613
0.02544
0
33,416
A
G
C
C
C
C
T
A
C
T
C
A
C
T
C
T
T
C
G
T
A
T
A
G
G
A
G
A
G
C
C
A
C
T
A
T
G
T
A
G
G
T
G
A
G
G
G
C
C
A
C
C
A
G
C
A
C
C
G
T
C
A
G
G
A
T
0.007828
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0.021526
0.001957
0.015656
0.031311
0.017613
0.017613
0.029354
0.046967
0.086106
0.005871
0
0.011742
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0.066536
0.078278
0.037182
0.011742
0.019569
0.013699
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0.015656
0.035225
0.039139
0.121331
0.037182
0.009785
0.001957
0.02544
0
33,417
C
G
A
G
C
G
C
A
G
G
A
A
G
T
T
C
A
G
G
A
G
C
A
G
G
A
T
G
G
T
G
A
C
G
C
T
T
A
G
A
G
A
G
T
A
G
C
A
G
G
C
C
A
G
G
T
A
G
G
G
G
G
A
T
C
T
0.013699
0.021526
0.029354
0.011742
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0.041096
0.013699
0.017613
0.04501
0.064579
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0.023483
0.048924
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0.054795
0.082192
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0.066536
0.02544
0.011742
0.046967
0.039139
0.041096
0.017613
0.013699
0.02544
0
33,418
C
G
T
A
G
C
C
A
G
G
G
A
A
A
G
C
C
G
G
C
C
T
C
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G
C
A
G
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C
C
T
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G
C
T
G
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G
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G
C
A
G
G
G
C
C
T
T
G
C
T
G
C
C
T
C
G
G
G
0.017613
0.013699
0.027397
0.005871
0.023483
0.035225
0.011742
0.023483
0.019569
0.058708
0.060665
0.013699
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0.017613
0.017613
0.041096
0.084149
0.050881
0.062622
0.037182
0.017613
0.033268
0.019569
0.033268
0.019569
0.019569
0.066536
0.091977
0.021526
0.019569
0.009785
0.019569
0
33,419
G
C
A
G
G
C
A
G
T
A
T
G
C
A
G
A
G
C
A
G
G
G
C
G
C
C
C
A
G
G
T
G
C
C
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T
T
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C
G
G
A
C
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C
A
C
T
C
C
C
T
G
C
A
C
G
T
C
C
A
G
C
A
G
A
0.013699
0.005871
0.031311
0.003914
0.019569
0.031311
0.009785
0.02544
0.017613
0.052838
0.074364
0.011742
0.003914
0.019569
0.017613
0.043053
0.088063
0.062622
0.103718
0.019569
0.007828
0.013699
0.011742
0.039139
0.021526
0.019569
0.068493
0.084149
0.041096
0.017613
0.001957
0.017613
0
33,420
T
C
C
T
G
T
T
C
C
C
C
T
T
T
G
G
G
T
T
C
A
T
C
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C
T
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T
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T
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T
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C
T
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G
A
G
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A
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C
A
A
A
G
A
T
G
C
C
C
C
A
A
C
T
G
C
A
G
A
G
0.050881
0.021526
0.037182
0.017613
0.029354
0.033268
0.007828
0.023483
0.02544
0.054795
0.058708
0.011742
0.029354
0.035225
0.02544
0.029354
0.074364
0.048924
0.050881
0.005871
0.003914
0.017613
0.013699
0.037182
0.02544
0.017613
0.052838
0.031311
0.048924
0.023483
0.02544
0.031311
0
33,421
C
C
T
A
C
C
T
T
C
C
T
G
A
C
C
T
C
A
T
G
T
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C
C
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G
A
C
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A
C
C
G
G
C
G
C
A
T
T
G
A
T
G
A
C
C
A
C
A
C
A
G
C
A
A
G
T
G
T
C
T
C
C
T
0.031311
0.017613
0.037182
0.013699
0.043053
0.029354
0.003914
0.031311
0.054795
0.033268
0.066536
0.001957
0.023483
0.019569
0.023483
0.043053
0.072407
0.039139
0.056751
0.011742
0
0.011742
0.019569
0.058708
0.037182
0.021526
0.033268
0.043053
0.04501
0.02544
0.007828
0.043053
0
33,422
C
G
C
C
T
C
C
C
T
G
A
C
A
G
C
A
G
G
G
C
C
G
C
C
C
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C
C
C
G
G
G
C
C
T
T
C
T
G
G
C
T
G
C
C
C
C
T
G
A
G
C
C
G
C
G
C
G
A
T
G
G
G
C
T
T
0.007828
0.011742
0.031311
0
0.015656
0.015656
0.02544
0.003914
0.021526
0.060665
0.048924
0
0.003914
0.007828
0.015656
0.023483
0.050881
0.041096
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0.076321
0.027397
0.121331
0.005871
0.04501
0.027397
0.019569
0.031311
0.11546
0.035225
0.005871
0
0.011742
0
33,423
C
A
G
C
G
C
A
C
G
T
G
C
C
A
C
C
G
G
C
G
C
C
G
C
A
G
G
C
C
A
G
C
T
G
G
T
G
G
G
C
C
T
T
C
G
T
G
G
A
G
C
C
C
C
C
T
G
C
C
G
T
G
A
G
C
G
0.001957
0.003914
0.015656
0
0.005871
0.019569
0.02544
0.005871
0.011742
0.060665
0.052838
0
0
0
0.009785
0.031311
0.041096
0.039139
0.121331
0.09589
0.031311
0.113503
0.009785
0.064579
0.009785
0.017613
0.02544
0.131115
0.037182
0.005871
0
0.011742
0
33,424
C
T
T
C
T
C
T
T
C
T
G
A
A
G
C
T
G
A
G
G
G
C
A
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G
T
G
G
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G
G
T
G
C
C
A
G
G
T
G
G
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G
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G
G
G
C
G
C
T
G
C
T
G
T
G
G
G
A
G
C
A
G
C
0.015656
0.009785
0.031311
0
0.027397
0.041096
0.003914
0.015656
0.039139
0.054795
0.080235
0
0.007828
0.007828
0.02544
0.052838
0.084149
0.064579
0.082192
0.017613
0.003914
0.017613
0.005871
0.068493
0.013699
0.019569
0.056751
0.076321
0.04501
0.007828
0.001957
0.021526
0
33,425
G
G
A
A
G
A
T
C
T
T
C
C
A
G
G
G
G
G
C
G
T
C
C
T
G
A
T
A
G
C
C
G
T
A
G
A
A
G
T
T
G
G
G
A
T
T
G
A
T
G
A
G
G
C
G
G
T
G
C
A
G
C
C
G
C
A
0.031311
0.017613
0.02544
0.017613
0.013699
0.019569
0.013699
0.021526
0.029354
0.046967
0.062622
0.027397
0.021526
0.003914
0.019569
0.021526
0.064579
0.027397
0.093933
0.037182
0.019569
0.043053
0.015656
0.056751
0.027397
0.019569
0.041096
0.060665
0.048924
0.009785
0.013699
0.027397
0
33,426
G
C
T
G
C
C
C
T
C
A
G
T
G
C
C
C
A
G
G
G
C
T
G
C
T
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T
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C
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T
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C
A
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C
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C
A
G
G
A
C
C
A
C
T
G
T
G
A
C
T
C
G
G
G
C
0.005871
0.009785
0.027397
0.007828
0.031311
0.039139
0.007828
0.033268
0.019569
0.050881
0.058708
0.007828
0.021526
0.023483
0.007828
0.060665
0.088063
0.056751
0.076321
0.019569
0.011742
0.019569
0.005871
0.041096
0.023483
0.02544
0.052838
0.056751
0.041096
0.015656
0.013699
0.039139
0
33,427
A
A
T
G
A
G
C
A
G
C
A
C
G
C
C
T
T
T
A
C
C
C
G
C
T
G
C
T
T
C
C
A
C
G
C
C
T
G
G
A
G
C
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C
C
T
T
C
T
G
C
A
A
G
G
C
C
C
T
G
G
C
C
T
A
T
0.005871
0.003914
0.033268
0.009785
0.033268
0.041096
0.011742
0.017613
0.023483
0.048924
0.072407
0.009785
0.015656
0.023483
0.023483
0.056751
0.076321
0.066536
0.066536
0.015656
0.003914
0.027397
0.013699
0.039139
0.017613
0.029354
0.046967
0.072407
0.041096
0.013699
0.005871
0.033268
0
33,428
G
G
G
C
T
G
C
T
C
C
C
A
C
G
G
G
G
G
C
A
G
A
A
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C
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A
G
C
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C
G
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C
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C
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C
A
C
G
G
C
C
C
A
G
C
A
G
C
G
A
G
G
G
T
C
C
C
T
A
0.007828
0.011742
0.019569
0.003914
0.019569
0.023483
0.023483
0.019569
0.011742
0.078278
0.050881
0
0.007828
0.015656
0.017613
0.039139
0.088063
0.064579
0.068493
0.04501
0.029354
0.037182
0.007828
0.04501
0.017613
0.027397
0.064579
0.09002
0.046967
0.007828
0
0.009785
0
33,429
A
C
A
G
G
T
C
C
T
G
C
A
G
C
C
A
G
A
G
G
T
T
C
C
C
C
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C
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C
C
C
C
T
C
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C
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A
G
G
C
C
A
A
G
A
G
G
A
G
G
C
G
G
T
C
G
T
0
0.009785
0.017613
0.003914
0.017613
0.033268
0.021526
0.011742
0.015656
0.084149
0.066536
0.001957
0.011742
0.013699
0.019569
0.029354
0.093933
0.062622
0.056751
0.039139
0.02544
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0.011742
0.054795
0.011742
0.039139
0.058708
0.076321
0.056751
0.005871
0
0.017613
0
33,430
G
C
C
A
T
G
G
G
C
C
A
C
A
A
A
G
C
G
T
T
C
C
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G
G
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C
T
C
C
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C
C
C
C
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G
A
G
C
A
T
T
0.027397
0.027397
0.021526
0.017613
0.04501
0.013699
0.005871
0.039139
0.035225
0.029354
0.068493
0.017613
0.039139
0.039139
0.023483
0.041096
0.060665
0.041096
0.035225
0.003914
0.015656
0.009785
0.023483
0.064579
0.029354
0.019569
0.035225
0.039139
0.058708
0.015656
0.013699
0.043053
0
33,431
C
C
A
G
T
T
C
T
G
G
A
G
G
A
C
T
G
A
T
G
C
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C
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C
A
T
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G
C
C
A
T
C
T
G
G
A
T
A
T
G
A
T
T
0.027397
0.011742
0.037182
0.023483
0.027397
0.031311
0.007828
0.033268
0.035225
0.041096
0.052838
0.013699
0.02544
0.031311
0.02544
0.043053
0.066536
0.060665
0.048924
0.013699
0.007828
0.009785
0.009785
0.046967
0.037182
0.029354
0.035225
0.043053
0.052838
0.017613
0.009785
0.043053
0
33,432
A
C
C
C
T
T
C
A
C
A
A
C
T
G
T
T
G
T
C
T
C
G
G
G
A
A
G
A
A
G
G
G
T
T
G
G
C
A
T
T
T
T
C
C
A
C
T
G
A
A
A
A
G
T
C
T
A
C
A
C
G
G
A
A
C
C
0.027397
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0.033268
0.011742
0.037182
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0.027397
0.035225
0.054795
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0.033268
0.031311
0.031311
0.043053
0.052838
0.015656
0.011742
0.029354
0
33,433
C
T
C
T
C
C
G
G
G
A
G
G
A
G
G
T
T
G
A
G
A
G
C
T
T
C
G
C
C
T
C
T
C
T
C
T
T
C
C
C
T
C
T
G
C
C
T
G
G
C
C
T
G
C
C
T
G
A
C
T
T
C
T
A
A
T
0.048924
0.017613
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0.027397
0.04501
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0.046967
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0.02544
0.029354
0.027397
0.050881
0.041096
0.011742
0.021526
0.033268
0
33,434
T
C
T
C
C
A
G
G
A
T
G
T
C
C
C
G
C
T
C
C
A
C
C
T
G
G
T
C
G
G
C
G
C
T
G
G
C
T
T
G
C
A
T
G
T
G
G
G
A
G
A
T
G
A
G
C
A
G
G
G
T
C
A
G
C
T
0.011742
0.011742
0.021526
0.003914
0.037182
0.043053
0.005871
0.015656
0.043053
0.041096
0.062622
0
0.017613
0.033268
0.019569
0.058708
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0.066536
0.09589
0.017613
0.003914
0.015656
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0.056751
0.013699
0.031311
0.052838
0.058708
0.043053
0
0.003914
0.029354
0
33,435
C
T
T
T
C
C
C
C
A
A
A
G
C
A
C
C
A
G
A
T
C
G
C
C
T
T
C
C
T
T
T
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C
G
A
G
G
C
C
A
C
A
A
A
G
G
C
G
A
G
A
A
C
C
T
C
C
A
G
A
A
A
T
A
G
A
0.035225
0.021526
0.050881
0.017613
0.017613
0.035225
0.015656
0.023483
0.035225
0.035225
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0.039139
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0.043053
0.027397
0.041096
0.052838
0.04501
0.003914
0.005871
0.039139
0
33,436
T
C
G
T
G
G
G
G
A
C
T
T
C
A
C
C
C
T
C
A
G
C
A
A
G
T
G
G
A
C
G
C
C
G
T
T
T
G
T
C
C
T
G
C
C
A
G
G
G
C
A
G
G
T
G
T
G
T
G
T
C
T
G
C
C
T
0.017613
0.029354
0.027397
0.011742
0.035225
0.035225
0.015656
0.041096
0.046967
0.023483
0.048924
0.007828
0.02544
0.013699
0.031311
0.052838
0.076321
0.072407
0.064579
0.009785
0.003914
0.005871
0.011742
0.046967
0.035225
0.039139
0.02544
0.041096
0.054795
0.005871
0.001957
0.041096
0
33,437
C
C
C
A
A
T
T
C
T
C
A
C
T
C
A
C
T
C
T
G
G
C
C
A
G
T
G
A
A
G
C
C
C
C
T
T
C
A
G
G
A
A
C
A
A
C
G
C
C
A
G
C
C
A
A
G
C
A
G
T
T
T
G
G
T
G
0.023483
0.033268
0.031311
0.015656
0.037182
0.035225
0.021526
0.027397
0.04501
0.02544
0.054795
0.011742
0.017613
0.013699
0.035225
0.037182
0.066536
0.056751
0.07045
0.017613
0.011742
0.007828
0.015656
0.039139
0.043053
0.043053
0.027397
0.037182
0.056751
0.007828
0.003914
0.029354
0
33,438
C
G
C
G
G
G
T
G
A
T
C
A
G
G
T
C
C
G
C
G
T
A
G
G
A
C
A
G
G
T
T
T
C
C
C
C
A
G
G
C
G
T
T
C
C
G
C
C
G
C
G
A
C
G
A
A
C
A
T
T
T
C
C
T
C
A
0.003914
0.021526
0.017613
0.005871
0.019569
0.035225
0.013699
0.017613
0.029354
0.054795
0.031311
0.003914
0.029354
0.023483
0.021526
0.027397
0.056751
0.039139
0.07045
0.086106
0.023483
0.056751
0.011742
0.046967
0.021526
0.027397
0.043053
0.076321
0.04501
0.009785
0.001957
0.027397
0
33,439
T
T
G
C
A
G
G
G
G
C
C
A
C
G
T
A
C
A
G
G
A
T
C
G
C
G
G
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C
G
G
C
T
C
T
G
G
G
G
C
T
C
G
A
A
C
T
C
C
G
G
G
T
C
C
A
G
C
T
C
C
A
C
T
T
A
0.003914
0.007828
0.027397
0
0.001957
0.021526
0.027397
0.009785
0.035225
0.046967
0.035225
0.001957
0.017613
0.011742
0.011742
0.017613
0.02544
0.033268
0.09002
0.123288
0.041096
0.074364
0
0.076321
0.021526
0.031311
0.02544
0.103718
0.064579
0.003914
0.001957
0.005871
0
33,440
T
T
C
T
T
G
T
C
G
T
T
A
G
T
T
C
T
G
T
C
T
T
C
C
C
A
G
G
A
T
T
C
T
C
C
C
C
A
T
T
T
C
C
A
A
G
A
G
A
A
G
A
G
C
A
C
A
G
A
A
G
A
G
G
G
C
0.039139
0.027397
0.043053
0.035225
0.037182
0.017613
0.003914
0.04501
0.072407
0.027397
0.031311
0.029354
0.031311
0.033268
0.021526
0.031311
0.048924
0.033268
0.031311
0.011742
0.007828
0.007828
0.031311
0.050881
0.04501
0.023483
0.031311
0.019569
0.039139
0.021526
0.039139
0.031311
0
33,441
A
A
T
C
C
T
C
C
A
T
A
A
T
C
A
T
A
G
C
C
T
T
T
G
C
G
C
C
A
C
T
A
T
T
T
G
G
G
T
G
T
A
G
C
A
A
C
C
T
T
T
C
C
G
T
T
C
T
C
C
A
C
A
T
A
A
0.080235
0.031311
0.04501
0.043053
0.041096
0.02544
0.005871
0.035225
0.052838
0.027397
0.035225
0.029354
0.019569
0.029354
0.039139
0.033268
0.052838
0.037182
0.015656
0.003914
0.003914
0.009785
0.019569
0.033268
0.046967
0.015656
0.04501
0.023483
0.027397
0.027397
0.033268
0.031311
0
33,442
G
C
T
C
C
T
G
C
T
T
A
C
T
C
T
T
C
T
C
C
A
T
C
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C
G
G
C
A
C
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C
C
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T
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C
T
C
C
A
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G
T
G
G
G
C
C
T
T
G
A
T
A
C
C
G
T
T
G
G
C
C
T
0.02544
0.027397
0.039139
0.017613
0.041096
0.023483
0.003914
0.02544
0.046967
0.048924
0.04501
0.019569
0.019569
0.041096
0.031311
0.039139
0.062622
0.056751
0.054795
0.009785
0.005871
0.007828
0.013699
0.050881
0.041096
0.011742
0.04501
0.046967
0.041096
0.015656
0.009785
0.031311
0
33,443
G
T
C
T
C
C
T
T
T
T
C
C
A
G
A
A
A
A
C
A
G
C
C
T
A
T
T
C
A
T
T
T
C
G
G
A
T
A
T
A
C
A
C
C
G
G
A
G
T
G
A
A
T
T
C
C
T
C
C
A
T
G
G
T
T
T
0.066536
0.029354
0.033268
0.027397
0.02544
0.041096
0.009785
0.029354
0.07045
0.017613
0.041096
0.021526
0.02544
0.02544
0.031311
0.023483
0.046967
0.062622
0.037182
0.011742
0.009785
0.009785
0.023483
0.054795
0.046967
0.027397
0.011742
0.027397
0.046967
0.02544
0.011742
0.027397
0
33,444
A
G
A
G
G
T
G
G
A
T
G
G
G
C
A
G
G
T
A
A
C
G
G
A
T
G
A
A
G
T
C
T
C
G
G
T
A
T
T
T
G
C
T
G
A
A
C
C
C
A
G
A
A
G
A
C
A
G
G
T
C
T
C
T
G
A
0.043053
0.031311
0.035225
0.02544
0.031311
0.04501
0.009785
0.023483
0.056751
0.027397
0.043053
0.021526
0.02544
0.033268
0.031311
0.027397
0.056751
0.066536
0.039139
0.013699
0.005871
0.009785
0.013699
0.043053
0.050881
0.02544
0.017613
0.031311
0.046967
0.02544
0.009785
0.033268
0
33,445
T
C
A
T
G
G
C
C
T
G
G
A
G
C
A
T
G
G
T
G
G
G
G
A
A
G
T
A
C
G
A
G
C
G
C
T
G
C
C
T
G
A
T
G
G
C
C
T
T
C
A
A
G
C
A
T
C
C
C
A
A
G
T
A
G
T
0.021526
0.017613
0.048924
0.013699
0.02544
0.039139
0.007828
0.037182
0.058708
0.031311
0.054795
0.003914
0.02544
0.035225
0.02544
0.037182
0.060665
0.052838
0.041096
0.009785
0.007828
0.005871
0.017613
0.052838
0.046967
0.031311
0.031311
0.037182
0.041096
0.023483
0.007828
0.048924
0
33,446
A
A
A
T
T
C
C
C
C
G
G
A
A
T
T
A
T
G
G
G
C
G
T
G
C
T
G
C
A
G
G
G
C
G
C
T
A
A
C
A
G
T
C
A
G
G
A
G
G
A
A
T
T
G
G
T
C
A
G
G
T
G
A
C
A
T
0.091977
0.031311
0.043053
0.056751
0.027397
0.019569
0.013699
0.033268
0.033268
0.013699
0.039139
0.023483
0.033268
0.027397
0.058708
0.017613
0.041096
0.037182
0.035225
0.007828
0.009785
0.007828
0.017613
0.017613
0.054795
0.02544
0.039139
0.021526
0.043053
0.019569
0.017613
0.041096
0
33,447
C
C
A
T
A
C
A
G
G
T
A
A
T
A
A
A
G
C
T
G
C
T
G
C
T
G
A
G
C
A
A
C
C
C
A
C
A
G
A
G
A
A
G
A
T
A
G
A
C
G
A
T
G
A
T
T
G
C
A
C
T
G
A
C
T
T
0.158513
0.033268
0.035225
0.060665
0.046967
0.017613
0.007828
0.035225
0.035225
0.027397
0.017613
0.043053
0.027397
0.041096
0.046967
0.027397
0.023483
0.015656
0.009785
0
0.011742
0
0.035225
0.021526
0.031311
0.017613
0.033268
0.009785
0.007828
0.029354
0.048924
0.043053
0
33,448
T
A
A
C
C
T
T
G
G
A
C
A
A
G
T
C
A
T
T
T
C
A
A
C
C
C
T
C
T
G
A
G
C
T
T
G
T
T
T
C
C
T
C
A
T
C
T
G
A
A
A
A
A
C
A
A
A
G
A
T
A
G
C
A
G
T
0.050881
0.02544
0.017613
0.033268
0.043053
0.043053
0.011742
0.023483
0.019569
0.035225
0.043053
0.011742
0.017613
0.027397
0.031311
0.04501
0.056751
0.064579
0.054795
0.017613
0.011742
0.037182
0.015656
0.029354
0.023483
0.02544
0.019569
0.052838
0.031311
0.02544
0.021526
0.033268
0
33,449
G
G
A
A
A
C
A
A
G
C
T
C
A
G
A
G
G
G
T
T
G
A
A
A
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A
C
T
T
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T
C
C
A
A
G
G
T
T
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C
A
G
G
C
C
A
G
T
G
G
A
G
G
C
T
T
G
A
A
C
C
C
A
T
0.050881
0.02544
0.017613
0.031311
0.043053
0.043053
0.013699
0.021526
0.019569
0.037182
0.043053
0.011742
0.015656
0.027397
0.031311
0.048924
0.056751
0.068493
0.060665
0.017613
0.011742
0.031311
0.017613
0.029354
0.023483
0.02544
0.017613
0.054795
0.029354
0.021526
0.019569
0.033268
0
33,450
T
T
T
C
C
C
C
T
C
A
C
A
G
A
C
T
C
T
T
G
A
A
T
T
T
G
T
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C
T
C
T
T
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T
T
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C
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G
G
C
A
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G
A
A
A
A
G
G
A
A
A
A
A
G
A
A
G
A
G
A
G
G
C
0.113503
0.039139
0.052838
0.058708
0.046967
0.005871
0
0.048924
0.052838
0.015656
0.023483
0.060665
0.021526
0.035225
0.027397
0.019569
0.035225
0.017613
0.015656
0
0.003914
0
0.027397
0.02544
0.054795
0.011742
0.015656
0.015656
0.019569
0.031311
0.066536
0.037182
0
33,451
C
G
A
G
G
A
A
G
C
C
A
G
C
G
G
G
G
C
G
G
A
T
G
G
G
G
T
C
C
C
C
A
T
C
G
A
G
G
C
C
G
A
G
C
C
G
C
T
G
C
C
C
T
C
C
C
T
G
G
A
G
T
A
C
T
C
0.001957
0.005871
0.019569
0.003914
0.015656
0.037182
0.015656
0.011742
0.031311
0.054795
0.050881
0.001957
0.021526
0.029354
0.011742
0.023483
0.050881
0.056751
0.084149
0.062622
0.035225
0.050881
0.013699
0.064579
0.017613
0.035225
0.023483
0.082192
0.050881
0.015656
0
0.019569
0
33,452
C
C
A
C
T
A
C
C
T
G
C
A
C
T
T
C
G
C
T
G
T
C
G
C
C
C
T
C
T
T
T
G
C
A
C
T
C
A
G
T
G
G
T
G
C
T
G
T
T
G
T
G
G
T
G
G
C
T
G
G
A
A
G
C
C
T
0.017613
0.009785
0.019569
0.017613
0.021526
0.043053
0.015656
0.019569
0.029354
0.043053
0.062622
0.001957
0.015656
0.015656
0.019569
0.048924
0.076321
0.074364
0.11546
0.013699
0.007828
0.009785
0.017613
0.041096
0.023483
0.035225
0.035225
0.056751
0.050881
0.007828
0.003914
0.029354
0
33,453
G
G
A
A
G
G
T
A
A
A
G
C
T
C
C
C
T
C
C
C
C
T
C
T
C
T
T
A
C
C
C
C
C
A
T
C
C
C
C
C
A
T
A
C
A
G
G
T
T
A
C
A
G
C
C
T
G
G
G
A
G
T
G
G
G
T
0.013699
0.029354
0.023483
0.009785
0.041096
0.052838
0.003914
0.015656
0.037182
0.037182
0.060665
0.003914
0.013699
0.027397
0.021526
0.043053
0.07045
0.068493
0.103718
0.021526
0.005871
0.007828
0.007828
0.048924
0.029354
0.023483
0.023483
0.056751
0.041096
0.015656
0.011742
0.029354
0
33,454
C
C
T
A
T
G
G
G
A
A
G
A
T
G
G
C
A
A
T
T
T
G
G
C
A
G
T
T
T
T
T
G
C
T
G
A
C
A
C
T
A
C
T
T
A
T
T
A
A
C
A
C
T
A
G
A
T
A
A
A
C
T
A
T
T
G
0.09002
0.033268
0.039139
0.064579
0.050881
0.011742
0.005871
0.039139
0.035225
0.023483
0.031311
0.064579
0.031311
0.035225
0.039139
0.023483
0.033268
0.029354
0.009785
0
0.001957
0.003914
0.033268
0.023483
0.037182
0.015656
0.017613
0.009785
0.037182
0.035225
0.060665
0.033268
0
33,455
C
C
A
C
C
A
T
C
C
T
C
A
C
G
G
A
C
G
T
G
G
A
C
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C
C
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T
C
C
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G
G
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A
T
G
C
A
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A
G
G
A
G
A
T
C
T
T
C
G
G
G
C
C
T
G
T
G
G
0.017613
0.027397
0.029354
0
0.023483
0.04501
0.023483
0.019569
0.039139
0.031311
0.068493
0.003914
0.023483
0.019569
0.027397
0.04501
0.074364
0.066536
0.07045
0.013699
0.007828
0.017613
0.013699
0.041096
0.02544
0.029354
0.050881
0.056751
0.048924
0.009785
0.003914
0.02544
0
33,456
T
A
A
C
G
G
T
T
G
A
T
C
A
T
A
C
T
G
A
G
C
C
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C
A
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T
C
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A
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C
A
T
T
T
T
A
G
C
A
A
T
C
T
T
C
C
A
A
G
C
0.084149
0.039139
0.041096
0.060665
0.039139
0.021526
0.007828
0.033268
0.033268
0.023483
0.027397
0.046967
0.031311
0.050881
0.035225
0.019569
0.033268
0.037182
0.021526
0.001957
0.007828
0.001957
0.029354
0.013699
0.04501
0.015656
0.027397
0.017613
0.029354
0.027397
0.060665
0.035225
0
33,457
G
A
A
G
G
G
G
C
A
G
C
A
A
G
T
C
A
C
A
C
T
G
G
C
G
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C
A
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C
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C
T
G
C
C
C
A
A
C
A
T
C
C
A
T
A
A
C
T
C
A
A
G
A
G
T
C
A
A
G
C
T
T
G
0.052838
0.031311
0.058708
0.017613
0.039139
0.015656
0.005871
0.039139
0.052838
0.043053
0.031311
0.015656
0.031311
0.037182
0.037182
0.021526
0.048924
0.033268
0.037182
0.013699
0.015656
0.007828
0.013699
0.04501
0.050881
0.031311
0.023483
0.019569
0.043053
0.017613
0.019569
0.048924
0
33,458
A
G
G
T
G
T
A
C
C
T
G
C
A
C
G
G
A
A
T
G
T
T
C
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T
T
C
C
C
A
T
G
A
C
T
A
A
T
G
A
T
A
G
G
C
0.058708
0.033268
0.043053
0.046967
0.04501
0.021526
0.003914
0.035225
0.050881
0.027397
0.041096
0.015656
0.029354
0.04501
0.029354
0.02544
0.052838
0.035225
0.021526
0.003914
0
0
0.033268
0.02544
0.060665
0.017613
0.027397
0.023483
0.037182
0.029354
0.035225
0.04501
0
33,459
G
C
A
C
A
C
A
G
A
T
G
G
G
T
A
G
C
T
C
C
T
C
T
G
G
C
T
G
G
C
C
C
T
G
T
G
T
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C
T
C
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C
C
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T
T
A
G
G
T
G
C
T
C
G
G
T
C
A
T
T
T
G
T
C
0.009785
0.011742
0.027397
0.011742
0.023483
0.033268
0.001957
0.007828
0.033268
0.058708
0.09002
0.011742
0.015656
0.035225
0.015656
0.029354
0.084149
0.066536
0.078278
0.005871
0.001957
0.005871
0.015656
0.060665
0.029354
0.007828
0.048924
0.076321
0.052838
0.017613
0.005871
0.02544
0
33,460
T
C
T
T
C
T
T
G
A
C
G
A
A
G
C
G
G
T
T
G
C
G
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C
A
C
C
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G
C
G
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C
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C
A
C
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T
G
C
C
G
T
T
G
C
C
G
A
A
G
C
C
G
T
T
G
T
0
0.021526
0.019569
0.005871
0.041096
0.041096
0.02544
0.005871
0.023483
0.052838
0.046967
0
0.013699
0.039139
0.023483
0.048924
0.066536
0.066536
0.056751
0.04501
0.017613
0.04501
0.011742
0.031311
0.023483
0.035225
0.041096
0.080235
0.035225
0.007828
0
0.027397
0
33,461
C
A
T
T
C
T
T
C
T
T
G
A
C
G
A
A
G
C
G
G
T
T
G
C
G
G
C
A
C
C
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G
C
G
C
C
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C
G
T
G
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G
C
A
C
C
T
T
G
C
C
G
T
T
G
C
C
G
A
A
G
C
C
G
T
0
0.021526
0.019569
0.005871
0.041096
0.041096
0.02544
0.003914
0.023483
0.052838
0.046967
0
0.015656
0.041096
0.023483
0.048924
0.064579
0.064579
0.056751
0.04501
0.017613
0.04501
0.011742
0.031311
0.023483
0.035225
0.041096
0.080235
0.035225
0.007828
0
0.029354
0
33,462
G
A
G
C
T
C
C
C
A
G
C
T
G
G
G
C
A
G
A
G
C
A
G
G
C
A
A
C
A
G
C
G
C
C
C
A
G
G
G
C
C
C
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C
G
C
T
C
C
A
T
C
T
C
C
G
T
G
T
C
A
G
C
T
C
T
0.003914
0.011742
0.02544
0.007828
0.033268
0.031311
0.019569
0.017613
0.027397
0.066536
0.048924
0.001957
0.011742
0.013699
0.015656
0.062622
0.084149
0.068493
0.097847
0.02544
0.001957
0.027397
0.003914
0.046967
0.027397
0.02544
0.039139
0.066536
0.046967
0.001957
0.001957
0.035225
0
33,463
A
C
T
C
A
C
T
G
G
A
C
T
C
A
G
G
T
A
G
G
G
A
G
C
C
T
G
G
G
A
A
C
C
G
C
T
G
A
A
G
G
C
C
A
T
C
T
C
T
C
C
G
C
C
G
C
C
T
C
T
G
T
G
G
C
T
0.02544
0.019569
0.035225
0.007828
0.031311
0.029354
0.005871
0.035225
0.037182
0.041096
0.066536
0.011742
0.011742
0.023483
0.023483
0.048924
0.064579
0.058708
0.068493
0.013699
0.003914
0.007828
0.013699
0.066536
0.033268
0.021526
0.033268
0.050881
0.058708
0.011742
0.005871
0.033268
0
33,464
G
C
C
T
C
T
G
T
G
T
T
G
A
A
C
T
C
A
C
T
T
T
T
T
G
T
C
T
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C
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C
C
C
C
C
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G
G
G
C
C
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G
G
G
T
G
G
G
A
A
A
C
A
G
A
C
A
G
G
C
T
G
G
T
0.021526
0.021526
0.037182
0.005871
0.027397
0.031311
0.013699
0.017613
0.058708
0.031311
0.074364
0.001957
0.009785
0.009785
0.019569
0.037182
0.078278
0.052838
0.082192
0.021526
0.009785
0.011742
0.007828
0.058708
0.033268
0.02544
0.043053
0.080235
0.037182
0.005871
0.011742
0.021526
0
33,465
C
C
A
C
C
C
A
G
G
G
C
C
T
C
T
G
T
G
T
T
G
A
A
C
T
C
A
C
T
T
T
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G
T
C
T
G
C
G
C
C
C
C
C
T
G
G
G
C
C
T
G
G
G
T
G
G
G
A
A
A
C
A
G
A
0.021526
0.021526
0.037182
0.005871
0.029354
0.033268
0.013699
0.015656
0.058708
0.029354
0.074364
0.001957
0.011742
0.011742
0.019569
0.035225
0.076321
0.054795
0.082192
0.021526
0.011742
0.011742
0.007828
0.056751
0.033268
0.027397
0.039139
0.080235
0.039139
0.005871
0.011742
0.019569
0
33,466
T
C
A
T
T
C
C
C
T
C
T
C
T
T
T
C
T
A
G
A
A
A
C
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G
A
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A
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C
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C
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C
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C
A
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C
T
G
A
A
A
G
A
G
C
T
C
A
A
C
A
A
C
A
A
A
T
T
0.046967
0.041096
0.043053
0.013699
0.046967
0.043053
0.005871
0.029354
0.052838
0.037182
0.052838
0.005871
0.005871
0.02544
0.035225
0.033268
0.066536
0.050881
0.046967
0.005871
0.005871
0.001957
0.021526
0.041096
0.04501
0.035225
0.027397
0.031311
0.035225
0.015656
0.015656
0.035225
0
33,467
A
G
G
T
C
T
T
C
G
A
T
G
C
C
C
G
C
A
G
C
T
G
T
T
C
C
A
C
T
G
C
C
C
G
G
G
A
A
A
T
G
T
T
T
G
A
A
C
A
C
A
T
C
T
G
C
A
G
A
C
A
C
G
T
G
T
0.033268
0.02544
0.033268
0.019569
0.035225
0.02544
0.005871
0.029354
0.052838
0.04501
0.035225
0.001957
0.027397
0.041096
0.033268
0.04501
0.068493
0.052838
0.046967
0.015656
0.013699
0.005871
0.011742
0.046967
0.041096
0.019569
0.064579
0.04501
0.033268
0.005871
0.003914
0.035225
0
33,468
G
G
C
C
A
T
G
C
T
G
C
A
A
A
C
G
C
C
C
T
C
T
C
C
A
G
C
T
C
C
A
G
T
A
G
C
T
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C
C
C
T
T
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G
C
T
G
A
A
G
G
T
G
G
T
C
C
G
C
T
T
T
C
T
C
0.011742
0.023483
0.035225
0.001957
0.02544
0.054795
0.007828
0.011742
0.02544
0.050881
0.072407
0
0.019569
0.029354
0.029354
0.043053
0.068493
0.07045
0.09002
0.013699
0.003914
0.009785
0.017613
0.039139
0.031311
0.019569
0.043053
0.056751
0.04501
0.013699
0
0.035225
0
33,469
C
A
A
C
C
A
G
A
A
C
T
C
C
C
G
C
C
G
G
C
C
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C
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G
T
T
C
T
C
C
A
G
T
G
A
G
G
A
G
A
G
C
A
T
0.013699
0.029354
0.041096
0.003914
0.033268
0.035225
0.015656
0.02544
0.035225
0.046967
0.048924
0.001957
0.015656
0.031311
0.037182
0.043053
0.064579
0.07045
0.04501
0.027397
0.003914
0.023483
0.021526
0.029354
0.031311
0.023483
0.046967
0.074364
0.035225
0.013699
0.005871
0.02544
0
33,470
G
A
T
G
C
C
C
C
A
G
C
T
G
T
T
G
A
T
G
G
C
C
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G
A
T
G
T
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G
A
G
G
A
G
G
A
A
T
C
C
T
G
C
0.019569
0.015656
0.035225
0.013699
0.033268
0.02544
0.005871
0.023483
0.017613
0.054795
0.07045
0.001957
0.013699
0.021526
0.037182
0.04501
0.068493
0.076321
0.09002
0.009785
0.001957
0.005871
0.013699
0.048924
0.019569
0.019569
0.04501
0.068493
0.062622
0.007828
0.007828
0.019569
0
33,471
A
G
A
G
G
A
C
A
C
C
C
T
C
A
C
T
G
C
C
C
C
C
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C
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C
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C
A
G
G
G
C
C
C
G
A
G
C
A
A
G
T
C
C
A
G
T
0.019569
0.003914
0.039139
0.011742
0.021526
0.031311
0.013699
0.017613
0.037182
0.046967
0.068493
0.005871
0.005871
0.019569
0.021526
0.031311
0.064579
0.056751
0.09002
0.029354
0.013699
0.017613
0.013699
0.052838
0.02544
0.033268
0.027397
0.09002
0.035225
0.015656
0.007828
0.031311
0
33,472
A
C
C
C
A
G
T
G
C
C
C
C
G
G
A
G
C
C
A
C
C
A
C
T
G
C
C
C
G
G
G
G
C
T
G
C
C
A
A
G
T
C
A
C
C
T
G
C
C
C
C
A
C
T
G
C
C
T
G
T
C
T
C
T
G
G
0.011742
0.009785
0.029354
0.003914
0.029354
0.04501
0.009785
0.021526
0.02544
0.04501
0.068493
0.005871
0.017613
0.023483
0.013699
0.052838
0.074364
0.064579
0.091977
0.02544
0.013699
0.005871
0.009785
0.04501
0.023483
0.029354
0.035225
0.072407
0.041096
0.013699
0.005871
0.035225
0
33,473
T
G
T
C
C
C
A
A
C
T
A
G
T
G
C
C
T
C
A
G
C
C
C
C
A
C
C
T
C
G
T
G
T
T
A
A
C
A
C
T
C
C
C
A
G
C
T
T
C
A
G
T
G
G
A
C
A
A
C
C
T
G
A
T
A
G
0.058708
0.031311
0.048924
0.021526
0.031311
0.033268
0.009785
0.035225
0.041096
0.033268
0.043053
0.02544
0.037182
0.037182
0.029354
0.027397
0.039139
0.048924
0.043053
0.005871
0.009785
0.001957
0.031311
0.033268
0.02544
0.023483
0.017613
0.029354
0.035225
0.029354
0.046967
0.035225
0
33,474
C
C
A
C
C
G
C
G
G
G
C
C
A
C
G
G
A
G
A
T
G
A
A
A
C
A
A
T
C
A
C
C
C
G
G
G
G
C
C
G
C
G
G
C
G
A
G
C
C
C
A
A
A
A
T
C
A
C
C
C
G
G
G
C
C
A
0.005871
0.011742
0.007828
0.017613
0.011742
0.035225
0.035225
0.013699
0.029354
0.015656
0.037182
0.003914
0.031311
0.013699
0.013699
0.021526
0.031311
0.031311
0.105675
0.101761
0.033268
0.076321
0.017613
0.039139
0.015656
0.041096
0.017613
0.09002
0.04501
0.021526
0.007828
0.019569
0
33,475
T
T
C
A
T
C
T
C
G
C
G
T
T
T
C
C
T
G
G
A
G
G
G
C
C
A
G
T
C
G
G
G
T
G
T
G
A
C
C
A
T
C
A
A
G
C
A
C
G
T
G
G
C
C
T
G
T
G
G
G
G
A
C
T
T
C
0.011742
0.019569
0.029354
0.013699
0.02544
0.035225
0.017613
0.029354
0.035225
0.031311
0.07045
0.019569
0.013699
0.013699
0.019569
0.050881
0.072407
0.052838
0.064579
0.011742
0.009785
0.027397
0.019569
0.04501
0.023483
0.02544
0.052838
0.064579
0.037182
0.011742
0.019569
0.02544
0