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int64
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string
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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T
G
G
G
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C
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A
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G
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G
G
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C
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C
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34,477
C
C
A
A
G
G
A
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C
A
G
G
G
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C
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C
C
A
C
A
A
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T
G
G
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G
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T
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34,478
G
G
C
G
C
C
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C
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T
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A
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C
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C
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34,479
A
C
C
T
G
G
G
A
A
A
A
C
G
G
G
A
G
A
G
A
C
G
C
C
C
C
C
C
A
C
T
G
C
G
C
T
G
G
C
T
C
C
C
C
C
A
G
C
C
G
G
C
C
A
C
C
T
G
G
C
A
T
C
T
G
T
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0
34,480
G
C
G
G
C
C
C
T
G
C
C
C
G
C
C
C
A
C
C
T
G
G
A
T
G
A
G
G
A
G
A
A
C
G
T
C
G
T
T
C
A
G
T
T
T
G
T
T
C
T
C
C
G
C
G
T
C
G
T
A
G
T
T
G
T
T
0.003914
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0
0.015656
0
34,481
C
G
C
C
T
G
G
A
C
C
C
C
C
G
G
C
C
G
T
C
A
C
G
G
A
C
G
G
T
C
C
T
C
T
G
G
A
T
G
C
A
G
A
T
G
G
T
C
C
A
G
G
G
A
T
C
T
G
G
G
G
G
T
C
C
T
0.013699
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0.039139
0.07045
0.052838
0.003914
0.011742
0.02544
0
34,482
C
T
G
G
A
C
T
G
G
C
T
G
C
C
A
G
C
C
A
G
C
G
A
C
G
G
C
C
T
G
G
T
T
A
G
C
C
G
C
C
T
G
C
A
G
C
C
C
A
A
G
C
A
G
C
C
C
C
T
T
C
G
T
C
T
C
0.003914
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0.060665
0.084149
0.054795
0
0.003914
0.013699
0
34,483
C
T
C
G
G
A
C
C
C
C
G
C
A
G
C
C
C
C
A
C
A
C
G
C
G
G
A
G
C
T
G
C
T
C
C
G
C
C
T
G
G
G
G
T
C
C
C
A
C
C
C
G
G
C
C
C
C
C
G
C
C
A
G
G
G
A
0.013699
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0.07045
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0.009785
0
34,484
C
C
G
C
A
C
C
T
T
C
C
G
C
T
G
G
A
G
C
T
C
C
C
A
G
G
C
G
C
T
G
A
T
G
T
A
A
T
T
C
T
T
G
C
C
C
A
G
C
T
G
C
G
C
C
G
C
C
A
G
C
A
G
A
T
C
0.001957
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0.09002
0.062622
0.02544
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0.027397
0.043053
0.080235
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0.011742
0.005871
0.021526
0
34,485
A
A
A
G
C
C
G
C
A
G
T
G
C
A
G
G
T
C
C
G
T
G
A
T
G
G
G
G
A
G
C
G
C
G
T
G
G
T
G
A
G
A
C
C
A
G
A
C
G
T
G
C
C
T
G
G
G
C
G
C
C
G
G
A
A
T
0.009785
0.007828
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0.011742
0.046967
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0
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0
0.050881
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0.046967
0.074364
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0.005871
0.029354
0
34,486
G
T
T
C
C
C
A
C
G
T
C
C
C
C
A
C
C
T
G
T
G
C
C
C
T
T
T
G
A
A
G
A
C
C
T
T
C
C
C
G
G
C
G
T
C
C
T
G
C
T
C
T
G
G
G
T
G
G
A
A
G
C
T
C
C
T
0.005871
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0.021526
0
0.023483
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0.078278
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0.015656
0.037182
0
0.052838
0.017613
0.054795
0.058708
0.064579
0.046967
0
0
0.031311
0
34,487
T
T
C
C
C
G
A
G
G
C
T
C
G
G
C
C
C
G
A
G
C
T
G
C
T
G
C
A
G
C
T
G
C
A
C
T
T
C
C
T
G
G
C
G
G
C
G
G
C
C
A
C
C
G
A
G
A
C
C
C
C
C
G
T
G
T
0.001957
0.001957
0.009785
0
0.005871
0.027397
0.021526
0.007828
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0.04501
0.052838
0
0.011742
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0.021526
0.052838
0.031311
0.136986
0.103718
0.02544
0.123288
0.001957
0.046967
0.007828
0.033268
0.035225
0.103718
0.056751
0.005871
0
0.011742
0
34,488
G
T
G
G
C
G
G
T
G
C
T
G
C
A
G
G
C
G
C
A
C
G
C
C
T
G
G
G
A
A
G
A
C
G
T
C
G
G
C
C
T
G
G
C
C
C
T
G
T
G
C
C
G
C
A
C
T
C
A
G
G
A
C
C
C
A
0.005871
0.011742
0.013699
0.001957
0.015656
0.050881
0.023483
0.011742
0.015656
0.04501
0.050881
0
0.017613
0.015656
0.007828
0.052838
0.072407
0.074364
0.107632
0.062622
0.013699
0.037182
0.007828
0.029354
0.013699
0.027397
0.048924
0.09002
0.048924
0.009785
0.005871
0.009785
0
34,489
G
G
C
C
G
G
C
T
G
C
A
G
G
T
C
C
C
C
G
C
A
G
T
T
G
A
C
C
G
G
G
G
C
G
G
G
G
A
G
G
A
G
G
G
C
T
C
G
C
T
T
C
G
G
C
T
G
C
A
C
C
T
G
G
G
T
0.007828
0.013699
0.019569
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0.019569
0.037182
0.017613
0.02544
0.007828
0.043053
0.04501
0
0.013699
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0.021526
0.052838
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0.072407
0.023483
0.048924
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0.011742
0.027397
0.04501
0.101761
0.039139
0.005871
0.003914
0.02544
0
34,490
C
A
C
G
G
C
C
C
C
C
G
C
C
C
C
C
A
C
A
G
G
G
T
G
C
C
C
A
G
G
T
C
T
G
G
C
C
C
A
A
G
C
T
G
C
G
T
G
T
G
G
T
A
A
C
G
C
T
G
T
T
G
G
A
A
C
0.005871
0.019569
0.021526
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0.037182
0.037182
0.037182
0.015656
0.009785
0.046967
0.046967
0
0.003914
0.007828
0.019569
0.060665
0.07045
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0.023483
0.043053
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0.019569
0.019569
0.033268
0.048924
0.091977
0.033268
0.013699
0.005871
0.009785
0
34,491
C
G
G
T
G
C
C
T
T
T
A
T
G
T
G
G
C
C
C
C
T
G
C
A
C
T
G
G
T
C
C
A
C
G
T
G
G
C
T
G
G
G
C
G
T
C
T
T
T
G
C
G
G
C
C
C
T
G
C
A
C
C
T
C
A
T
0.003914
0.007828
0.029354
0
0.019569
0.046967
0.04501
0.017613
0.023483
0.041096
0.046967
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0.009785
0.021526
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0.035225
0.021526
0.031311
0.04501
0.091977
0.027397
0.023483
0.001957
0.031311
0
34,492
G
A
A
G
G
C
G
T
G
C
T
C
G
C
C
C
A
G
C
G
A
G
C
T
G
A
G
C
A
G
A
G
C
G
C
T
G
C
C
C
A
G
G
C
C
C
A
G
G
C
A
C
A
G
C
A
A
C
A
C
G
A
A
G
A
T
0.009785
0.019569
0.021526
0.003914
0.015656
0.039139
0.013699
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0
0.007828
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0.050881
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0.005871
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0
34,493
C
G
C
C
G
C
G
A
G
A
G
G
G
C
C
C
C
G
T
C
T
G
G
C
T
G
T
G
C
T
C
C
T
A
C
G
G
C
C
G
C
C
C
G
C
C
C
G
C
C
G
C
A
A
G
G
C
C
C
A
C
G
G
G
G
A
0.003914
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0
0.001957
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0.046967
0.078278
0.101761
0.019569
0.09589
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0.013699
0.023483
0.041096
0.123288
0.048924
0.001957
0
0.009785
0
34,494
T
G
T
C
T
C
T
T
C
T
C
G
C
C
C
T
G
G
C
G
G
G
G
A
A
G
G
T
G
A
G
G
C
C
C
A
G
A
G
A
G
G
G
G
C
A
G
C
C
A
C
C
T
G
C
C
C
A
G
A
G
T
C
A
C
T
0.033268
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0.064579
0.02544
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0.043053
0.050881
0.035225
0.009785
0.009785
0.041096
0
34,495
G
T
A
G
A
G
G
G
G
C
A
G
G
G
A
G
A
G
G
A
G
T
C
G
G
G
G
G
C
A
C
C
C
G
G
G
C
G
A
G
C
C
C
C
A
C
C
T
G
G
C
T
G
G
C
A
C
A
C
T
T
G
T
T
C
T
0.015656
0.011742
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0.027397
0.039139
0.033268
0.054795
0.052838
0.007828
0.005871
0.023483
0
34,496
C
C
C
C
T
C
T
A
C
A
C
C
C
T
G
T
G
G
T
C
T
C
G
G
C
C
C
C
T
C
C
C
T
G
G
G
G
C
C
A
C
C
T
C
C
A
G
C
T
T
C
T
C
T
C
C
C
C
A
C
T
C
T
C
A
C
0.041096
0.011742
0.02544
0.023483
0.021526
0.041096
0.007828
0.023483
0.050881
0.021526
0.056751
0.019569
0.019569
0.027397
0.017613
0.041096
0.048924
0.058708
0.082192
0.019569
0.017613
0.009785
0.017613
0.060665
0.023483
0.033268
0.031311
0.050881
0.043053
0.009785
0.019569
0.023483
0
34,497
G
A
G
T
G
G
G
G
C
C
T
C
G
T
A
C
C
T
C
C
T
G
G
G
C
C
A
G
G
T
C
C
T
C
A
G
C
G
G
C
C
T
C
C
A
A
C
A
A
G
C
T
G
T
G
C
A
A
G
G
G
C
T
C
C
C
0.017613
0.021526
0.021526
0.013699
0.019569
0.031311
0.009785
0.027397
0.039139
0.039139
0.07045
0.007828
0.017613
0.015656
0.033268
0.031311
0.07045
0.068493
0.084149
0.011742
0.005871
0.019569
0.017613
0.064579
0.015656
0.02544
0.033268
0.068493
0.050881
0.009785
0.007828
0.029354
0
34,498
C
T
C
C
C
A
C
A
C
C
T
C
C
C
G
G
A
C
A
T
C
C
C
T
C
A
G
C
A
G
G
G
T
G
A
G
C
T
C
C
T
C
G
A
A
G
G
T
C
C
G
G
T
T
C
A
C
C
T
G
T
G
G
A
C
C
0.035225
0.009785
0.019569
0.005871
0.023483
0.048924
0.009785
0.019569
0.027397
0.033268
0.064579
0.001957
0.031311
0.027397
0.011742
0.058708
0.054795
0.060665
0.093933
0.033268
0.011742
0.011742
0.007828
0.060665
0.021526
0.02544
0.037182
0.043053
0.066536
0.007828
0.001957
0.033268
0
34,499
C
C
T
C
C
G
T
C
A
C
T
C
G
G
C
C
C
A
G
C
G
T
G
C
C
C
A
C
C
A
G
G
T
G
C
C
C
C
A
C
A
T
C
A
G
C
G
T
G
T
G
C
G
T
C
C
T
G
C
C
A
G
C
T
G
C
0.013699
0.009785
0.013699
0.003914
0.023483
0.041096
0.011742
0.019569
0.02544
0.031311
0.082192
0
0.023483
0.019569
0.003914
0.046967
0.07045
0.060665
0.09002
0.035225
0.015656
0.027397
0.017613
0.054795
0.019569
0.029354
0.033268
0.076321
0.062622
0.009785
0.003914
0.023483
0
34,500
G
G
C
A
G
T
C
G
G
G
C
A
G
C
A
G
G
C
G
C
C
G
G
G
C
A
C
C
G
G
G
C
C
G
G
C
T
A
C
A
C
T
G
G
C
A
G
G
C
T
G
G
G
G
A
T
G
G
A
G
A
C
T
C
T
T
0.001957
0.019569
0.02544
0.001957
0.019569
0.054795
0
0.027397
0.02544
0.04501
0.066536
0.003914
0.003914
0.013699
0.019569
0.04501
0.09589
0.082192
0.088063
0.031311
0.003914
0.019569
0.007828
0.035225
0.027397
0.035225
0.048924
0.074364
0.048924
0.003914
0
0.023483
0
34,501
A
G
G
A
C
A
T
G
C
A
G
G
G
T
G
G
A
G
G
G
A
C
T
C
A
C
A
G
T
G
C
A
C
C
C
T
C
A
G
A
C
A
G
C
T
G
C
T
C
C
T
T
G
G
T
G
A
G
G
T
T
C
A
A
G
G
0.019569
0.029354
0.021526
0.011742
0.035225
0.056751
0.013699
0.015656
0.02544
0.035225
0.068493
0.009785
0.017613
0.023483
0.039139
0.052838
0.062622
0.062622
0.086106
0.011742
0.003914
0.009785
0.009785
0.048924
0.015656
0.031311
0.041096
0.039139
0.046967
0.007828
0.007828
0.039139
0
34,502
C
A
G
G
C
G
G
C
C
T
C
C
A
T
G
T
G
C
C
T
C
G
C
G
C
A
G
C
T
C
C
G
C
C
C
C
A
G
G
G
A
A
C
T
C
G
G
C
C
G
C
C
A
C
G
A
A
G
G
C
C
G
C
T
G
A
0.007828
0.001957
0.017613
0.005871
0.009785
0.033268
0.023483
0.019569
0.019569
0.048924
0.050881
0.005871
0.015656
0.007828
0.009785
0.041096
0.060665
0.050881
0.097847
0.066536
0.015656
0.074364
0.015656
0.046967
0.013699
0.027397
0.035225
0.091977
0.043053
0.015656
0.001957
0.023483
0
34,503
A
G
G
C
C
T
C
G
G
T
G
T
C
C
C
C
G
T
G
G
C
T
C
T
C
A
C
C
G
T
C
A
C
G
C
A
A
C
A
C
A
C
A
C
T
C
C
T
T
A
A
G
T
T
T
C
T
C
A
A
G
G
C
C
C
T
0.019569
0.005871
0.031311
0.005871
0.031311
0.023483
0.021526
0.017613
0.02544
0.050881
0.064579
0.001957
0.015656
0.015656
0.017613
0.048924
0.054795
0.058708
0.074364
0.04501
0.015656
0.027397
0.005871
0.066536
0.011742
0.033268
0.017613
0.084149
0.058708
0.005871
0.013699
0.029354
0
34,504
G
C
T
G
C
G
C
C
A
T
G
T
G
T
A
T
C
T
G
C
G
G
G
A
C
G
G
C
G
C
A
C
C
C
G
G
T
G
C
T
G
G
A
C
G
A
G
G
G
C
C
C
C
G
T
G
C
G
C
T
G
C
C
G
G
T
0.007828
0.011742
0.009785
0
0.009785
0.046967
0.02544
0.001957
0.009785
0.039139
0.046967
0.001957
0.005871
0.007828
0.003914
0.033268
0.052838
0.035225
0.125245
0.111546
0.02544
0.099804
0.001957
0.033268
0.013699
0.035225
0.043053
0.099804
0.043053
0.003914
0.003914
0.009785
0
34,505
C
C
G
C
C
G
C
T
T
G
T
C
C
A
G
G
G
T
C
T
T
G
G
T
G
G
C
C
G
T
G
C
T
G
C
C
T
G
C
T
C
C
C
G
G
C
G
C
G
C
T
G
C
C
A
G
C
C
T
G
C
T
C
C
T
C
0.039139
0.021526
0.031311
0.003914
0.027397
0.029354
0.011742
0.019569
0.02544
0.050881
0.07045
0.001957
0.009785
0.015656
0.043053
0.033268
0.056751
0.064579
0.048924
0.029354
0.013699
0.035225
0.003914
0.074364
0.009785
0.027397
0.04501
0.066536
0.068493
0.005871
0.003914
0.011742
0
34,506
A
T
C
T
G
G
A
A
G
T
G
C
A
C
G
G
G
C
A
G
C
G
G
C
G
C
C
G
T
C
T
G
C
A
T
A
T
G
C
A
T
C
A
T
C
T
G
G
T
A
G
T
A
G
G
A
G
A
T
C
G
T
G
G
C
T
0.003914
0.003914
0.02544
0
0.015656
0.039139
0.029354
0.011742
0.027397
0.052838
0.04501
0.009785
0.02544
0.027397
0.015656
0.041096
0.062622
0.048924
0.058708
0.066536
0.015656
0.054795
0.009785
0.039139
0.013699
0.031311
0.062622
0.076321
0.046967
0.019569
0
0.019569
0
34,507
T
G
T
G
G
C
C
C
C
G
C
C
C
G
A
G
C
C
C
C
T
G
C
C
C
A
C
G
C
C
C
T
T
G
G
A
G
C
C
T
T
C
C
A
C
C
G
G
C
A
C
T
C
A
T
G
A
C
G
G
C
C
T
G
C
C
0.021526
0.013699
0.029354
0.009785
0.023483
0.035225
0.017613
0.011742
0.023483
0.054795
0.062622
0.005871
0.009785
0.017613
0.02544
0.039139
0.058708
0.064579
0.103718
0.033268
0.013699
0.021526
0.02544
0.039139
0.021526
0.02544
0.037182
0.080235
0.043053
0.009785
0.005871
0.015656
0
34,508
T
C
C
T
G
C
C
C
T
G
A
C
C
C
T
C
C
A
C
C
T
C
C
T
C
C
C
T
A
G
G
A
C
C
C
C
T
G
T
G
C
C
T
C
C
T
G
C
A
G
A
G
A
G
A
C
C
C
G
C
A
T
G
G
C
T
0.007828
0.011742
0.021526
0
0.027397
0.043053
0.011742
0.021526
0.019569
0.046967
0.066536
0
0.005871
0.013699
0.017613
0.052838
0.076321
0.066536
0.101761
0.041096
0.009785
0.027397
0.013699
0.043053
0.011742
0.037182
0.046967
0.082192
0.048924
0.001957
0.003914
0.019569
0
34,509
C
A
G
G
G
G
G
C
G
G
G
C
T
G
G
C
C
A
G
A
A
A
G
G
G
G
C
G
G
G
G
G
T
G
C
G
G
G
A
A
G
G
C
C
A
C
G
G
C
G
T
C
G
C
C
C
G
C
C
C
G
G
G
C
A
C
0.007828
0.003914
0.021526
0.007828
0.037182
0.023483
0.015656
0.015656
0.021526
0.035225
0.062622
0.003914
0.007828
0.023483
0.011742
0.060665
0.052838
0.052838
0.123288
0.04501
0.007828
0.048924
0.013699
0.048924
0.017613
0.015656
0.048924
0.086106
0.050881
0.013699
0.003914
0.009785
0
34,510
C
C
G
C
C
C
C
C
G
G
C
C
C
A
T
C
G
G
C
A
C
G
A
T
T
C
A
C
C
T
C
G
C
C
C
G
G
T
C
C
T
G
A
G
G
T
C
C
C
A
G
G
G
A
C
G
C
A
G
C
T
G
G
G
G
T
0.001957
0.005871
0.011742
0.009785
0.011742
0.033268
0.02544
0.007828
0.013699
0.039139
0.041096
0
0.003914
0.001957
0.007828
0.04501
0.048924
0.039139
0.1409
0.097847
0.015656
0.111546
0
0.039139
0.015656
0.027397
0.043053
0.099804
0.046967
0
0.003914
0.009785
0
34,511
T
G
G
C
C
C
T
G
C
C
C
G
G
G
G
G
G
C
C
G
C
G
G
G
T
C
A
C
C
A
G
G
C
G
C
C
T
G
C
A
T
A
C
T
G
G
G
G
A
C
G
T
G
T
C
C
C
G
C
T
C
C
C
G
C
T
0.003914
0.003914
0.009785
0.009785
0.060665
0.029354
0.039139
0.011742
0.021526
0.033268
0.039139
0.007828
0.017613
0.039139
0.009785
0.082192
0.054795
0.041096
0.084149
0.052838
0.011742
0.041096
0.005871
0.035225
0.013699
0.04501
0.04501
0.062622
0.039139
0.009785
0
0.039139
0
34,512
G
A
A
G
G
T
G
A
G
G
A
T
C
A
G
G
G
T
G
C
T
G
A
G
C
A
G
G
A
G
T
C
C
C
G
T
C
T
C
G
A
G
G
A
T
G
G
G
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C
A
C
C
C
A
C
C
T
G
C
T
A
A
C
C
T
0.007828
0.011742
0.021526
0.005871
0.023483
0.048924
0.023483
0.021526
0.048924
0.035225
0.046967
0
0.031311
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0.017613
0.043053
0.062622
0.054795
0.086106
0.041096
0.015656
0.009785
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0.017613
0.039139
0.039139
0.048924
0.04501
0.021526
0.003914
0.033268
0
34,513
C
G
G
A
G
C
T
C
G
G
G
C
G
G
G
T
C
C
T
A
C
A
G
A
G
A
C
A
G
T
T
A
T
G
A
C
A
G
T
T
A
C
G
G
T
A
A
G
T
C
A
C
A
C
T
C
C
G
A
G
G
G
C
G
C
C
0.023483
0.015656
0.033268
0.011742
0.043053
0.031311
0.013699
0.027397
0.043053
0.050881
0.043053
0.003914
0.007828
0.019569
0.033268
0.039139
0.068493
0.046967
0.048924
0.035225
0.011742
0.029354
0.013699
0.048924
0.019569
0.043053
0.04501
0.058708
0.037182
0.017613
0.007828
0.027397
0
34,514
C
A
G
G
C
A
C
A
A
G
C
T
A
G
C
C
T
T
C
T
G
C
G
C
T
G
A
G
T
T
T
C
C
T
C
C
C
C
T
C
T
T
A
C
T
T
G
C
A
A
G
A
G
T
C
C
A
A
T
T
T
T
T
G
T
T
0.033268
0.021526
0.041096
0.009785
0.027397
0.023483
0.021526
0.023483
0.041096
0.035225
0.064579
0
0.013699
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0.039139
0.052838
0.04501
0.07045
0.02544
0.013699
0.019569
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0.066536
0.033268
0.033268
0.041096
0.052838
0.058708
0.001957
0.001957
0.031311
0
34,515
C
T
G
T
C
A
G
C
A
C
C
A
G
G
G
G
G
T
G
C
G
A
A
C
T
C
C
C
T
C
C
C
T
A
C
T
G
C
G
G
G
C
G
C
A
C
A
G
A
T
G
C
T
T
C
C
C
A
G
C
C
T
C
G
G
C
0.037182
0.027397
0.023483
0.02544
0.031311
0.02544
0.019569
0.037182
0.021526
0.039139
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0.009785
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0.015656
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0.04501
0.064579
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0.054795
0.02544
0.019569
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0.007828
0.043053
0.027397
0.021526
0.048924
0.035225
0.046967
0.019569
0.02544
0.029354
0
34,516
C
G
T
T
C
C
A
T
C
T
C
C
C
G
G
C
A
G
C
T
C
C
A
G
C
G
T
G
G
G
C
C
C
G
G
C
T
G
T
G
C
A
G
G
C
A
C
G
A
G
G
T
G
T
C
C
A
T
C
A
G
A
G
C
G
T
0.007828
0.011742
0.019569
0.005871
0.027397
0.031311
0.017613
0.023483
0.02544
0.041096
0.050881
0.001957
0.019569
0.035225
0.017613
0.046967
0.076321
0.074364
0.091977
0.027397
0.015656
0.029354
0
0.04501
0.019569
0.031311
0.04501
0.076321
0.04501
0.007828
0.001957
0.029354
0
34,517
G
G
A
G
G
C
C
G
G
C
T
T
C
C
G
G
A
G
G
G
A
G
A
A
C
A
T
C
C
G
T
A
C
G
G
A
G
G
T
G
A
T
G
G
C
G
C
T
G
G
T
C
C
C
A
C
C
G
G
C
C
G
A
C
T
T
0.005871
0.005871
0.021526
0.003914
0.027397
0.04501
0.023483
0.009785
0.019569
0.054795
0.048924
0
0.023483
0.019569
0.005871
0.066536
0.072407
0.068493
0.09589
0.052838
0.005871
0.027397
0.003914
0.035225
0.023483
0.023483
0.037182
0.080235
0.048924
0.009785
0.001957
0.031311
0
34,518
C
A
G
C
C
C
T
G
G
C
G
A
G
C
G
C
C
C
T
G
C
C
C
G
G
C
G
C
A
C
C
A
C
C
T
C
C
G
A
G
A
G
C
C
C
G
T
C
C
C
G
C
C
T
G
C
C
T
G
T
G
C
G
C
G
G
0
0.001957
0.013699
0
0.011742
0.013699
0.02544
0.005871
0.013699
0.052838
0.041096
0
0.009785
0.009785
0.005871
0.021526
0.050881
0.017613
0.09002
0.123288
0.035225
0.138943
0.003914
0.04501
0.005871
0.031311
0.046967
0.136986
0.031311
0.001957
0.001957
0.011742
0
34,519
C
A
G
G
C
G
T
G
A
G
C
C
A
C
C
A
C
A
C
C
T
G
G
C
T
G
C
A
T
C
C
G
T
C
A
T
G
T
T
A
A
G
A
A
G
A
C
C
C
C
G
G
C
T
G
G
C
A
A
G
C
T
C
A
C
G
0.021526
0.015656
0.023483
0.011742
0.02544
0.029354
0.017613
0.023483
0.031311
0.054795
0.054795
0.009785
0.02544
0.023483
0.027397
0.039139
0.07045
0.050881
0.066536
0.027397
0.009785
0.015656
0.019569
0.050881
0.011742
0.023483
0.056751
0.062622
0.043053
0.017613
0.011742
0.027397
0
34,520
T
G
C
G
C
C
T
G
G
T
C
T
T
G
G
C
C
C
T
G
G
C
C
C
T
T
G
T
C
C
G
C
C
C
C
C
G
G
G
C
T
G
T
G
G
G
G
T
G
G
G
C
C
C
C
G
G
T
C
C
G
A
G
C
C
T
0.007828
0.013699
0.027397
0.009785
0.017613
0.033268
0.017613
0.011742
0.02544
0.035225
0.052838
0.009785
0.013699
0.009785
0.027397
0.023483
0.046967
0.050881
0.133072
0.062622
0.023483
0.056751
0.015656
0.035225
0.017613
0.039139
0.027397
0.088063
0.04501
0.003914
0.005871
0.011742
0
34,521
C
C
T
C
A
G
G
G
C
G
A
A
G
G
C
T
T
C
C
A
G
C
C
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C
C
C
G
C
A
G
T
T
G
G
G
C
A
T
G
T
A
G
C
A
C
A
C
T
T
G
G
C
T
G
G
G
G
C
C
A
G
G
A
C
C
0.005871
0.005871
0.02544
0.003914
0.035225
0.037182
0.009785
0.015656
0.02544
0.056751
0.07045
0.007828
0.007828
0.015656
0.011742
0.054795
0.086106
0.062622
0.082192
0.031311
0.005871
0.027397
0.009785
0.048924
0.015656
0.031311
0.048924
0.074364
0.050881
0.005871
0.007828
0.021526
0
34,522
G
C
T
G
T
C
C
G
G
T
G
G
T
G
G
G
G
G
C
G
C
A
G
C
C
G
T
G
G
C
T
C
C
G
C
G
G
G
A
C
G
T
C
C
A
G
G
G
A
G
T
A
G
G
A
G
G
T
G
C
C
A
G
G
G
T
0.013699
0.011742
0.023483
0.005871
0.017613
0.046967
0.013699
0.033268
0.027397
0.037182
0.062622
0.003914
0.007828
0.017613
0.017613
0.052838
0.074364
0.07045
0.105675
0.021526
0.001957
0.017613
0.011742
0.050881
0.019569
0.033268
0.050881
0.050881
0.056751
0.013699
0.003914
0.023483
0
34,523
C
A
G
C
A
T
G
C
G
G
A
G
G
G
C
G
T
G
G
T
G
A
A
G
G
T
G
C
T
G
T
C
C
G
G
T
G
G
T
G
G
G
G
G
C
G
C
A
G
C
C
G
T
G
G
C
T
C
C
G
C
G
G
G
A
G
0.019569
0.009785
0.02544
0.011742
0.019569
0.046967
0.013699
0.029354
0.029354
0.037182
0.060665
0.003914
0.007828
0.019569
0.021526
0.048924
0.07045
0.068493
0.101761
0.021526
0.001957
0.017613
0.009785
0.048924
0.019569
0.035225
0.048924
0.048924
0.054795
0.015656
0.005871
0.02544
0
34,524
C
C
T
C
C
G
C
A
G
A
A
T
T
G
T
G
C
C
C
T
G
A
G
T
G
A
T
G
A
G
G
T
T
T
G
C
A
T
A
T
C
C
C
T
C
A
C
G
G
T
G
G
G
A
G
A
A
A
G
C
A
T
A
G
C
G
0.023483
0.005871
0.043053
0.017613
0.023483
0.027397
0.009785
0.017613
0.04501
0.048924
0.066536
0.015656
0.029354
0.035225
0.02544
0.033268
0.048924
0.043053
0.068493
0.013699
0.007828
0.007828
0.027397
0.060665
0.043053
0.023483
0.033268
0.035225
0.060665
0.015656
0
0.043053
0
34,525
C
T
C
A
C
A
C
A
G
A
A
A
C
G
G
G
A
A
G
G
T
C
G
T
G
G
G
G
G
A
T
A
C
T
C
T
G
A
A
G
A
G
C
C
A
G
A
A
G
C
T
C
T
G
G
G
T
G
G
T
G
G
T
A
G
T
0.013699
0.007828
0.035225
0.005871
0.021526
0.046967
0.015656
0.013699
0.019569
0.039139
0.068493
0.007828
0.017613
0.035225
0.023483
0.037182
0.056751
0.068493
0.099804
0.02544
0.011742
0.02544
0.015656
0.033268
0.019569
0.039139
0.037182
0.060665
0.054795
0.013699
0.005871
0.023483
0
34,526
A
G
C
A
C
C
T
C
G
G
A
G
C
T
A
C
G
G
C
G
G
G
C
T
C
T
G
G
A
G
T
C
C
T
G
G
G
C
T
G
G
C
G
G
T
G
C
A
G
C
C
A
G
C
G
G
G
A
G
C
C
C
G
A
A
T
0.003914
0.011742
0.015656
0.001957
0.015656
0.033268
0.031311
0.017613
0.015656
0.039139
0.064579
0
0.015656
0.013699
0.013699
0.039139
0.076321
0.07045
0.064579
0.052838
0.021526
0.062622
0.005871
0.039139
0.015656
0.037182
0.037182
0.105675
0.048924
0.009785
0
0.019569
0
34,527
G
C
G
C
G
C
G
G
C
T
C
C
T
T
C
C
G
C
A
G
G
G
A
C
A
C
C
A
G
C
A
G
T
T
T
G
T
C
C
T
G
G
C
C
G
G
C
G
G
G
G
A
G
G
G
G
G
C
T
G
T
G
C
C
A
C
0.007828
0.017613
0.013699
0.003914
0.019569
0.033268
0.021526
0.021526
0.015656
0.041096
0.074364
0
0.003914
0.007828
0.009785
0.02544
0.082192
0.060665
0.064579
0.054795
0.019569
0.066536
0.009785
0.04501
0.017613
0.043053
0.033268
0.093933
0.062622
0.009785
0.007828
0.011742
0
34,528
G
A
C
C
C
G
T
T
C
C
T
C
C
C
C
C
A
G
C
T
C
C
A
T
G
A
T
C
G
T
G
A
C
G
G
T
G
T
C
C
T
G
G
G
T
G
C
G
G
G
A
C
A
G
G
A
A
C
A
C
G
T
A
G
C
T
0.009785
0.019569
0.019569
0.007828
0.035225
0.046967
0.027397
0.009785
0.021526
0.035225
0.050881
0.005871
0.017613
0.027397
0.023483
0.046967
0.054795
0.066536
0.101761
0.039139
0.021526
0.033268
0.007828
0.035225
0.019569
0.031311
0.031311
0.064579
0.043053
0.021526
0.003914
0.019569
0
34,529
T
C
C
C
A
T
C
C
C
A
G
C
T
C
T
G
A
T
C
A
C
C
G
T
C
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C
A
C
C
T
C
C
G
C
G
G
A
T
G
C
C
A
G
C
A
G
G
A
C
C
T
G
A
G
C
C
T
T
C
C
T
G
A
G
T
0.011742
0.013699
0.015656
0.009785
0.009785
0.041096
0.015656
0.019569
0.039139
0.037182
0.068493
0.003914
0.013699
0.021526
0.017613
0.041096
0.066536
0.064579
0.11546
0.029354
0.003914
0.013699
0.015656
0.066536
0.019569
0.029354
0.037182
0.068493
0.050881
0.001957
0.001957
0.035225
0
34,530
C
C
A
A
G
A
G
G
A
C
C
C
T
T
G
C
G
G
C
C
A
G
C
G
G
C
A
G
C
C
A
G
T
C
C
T
C
C
A
A
C
G
G
C
C
C
T
G
A
G
C
C
A
G
G
T
G
G
C
C
A
G
C
A
G
C
0.003914
0.003914
0.019569
0.005871
0.027397
0.037182
0.019569
0.011742
0.013699
0.048924
0.064579
0
0.019569
0.02544
0.015656
0.058708
0.074364
0.072407
0.078278
0.035225
0.017613
0.04501
0.009785
0.033268
0.009785
0.023483
0.052838
0.103718
0.033268
0.009785
0.003914
0.021526
0
34,531
C
A
A
G
A
C
C
A
A
G
G
A
C
A
A
G
G
G
C
C
G
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G
G
G
C
G
G
C
C
T
G
T
G
G
A
G
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A
G
C
C
C
C
G
T
G
C
G
G
A
C
A
A
G
A
A
G
G
G
C
C
C
G
C
C
0.019569
0.003914
0.048924
0
0.015656
0.02544
0.013699
0.009785
0.029354
0.039139
0.066536
0
0.003914
0.003914
0.027397
0.027397
0.052838
0.056751
0.123288
0.072407
0.015656
0.035225
0.003914
0.039139
0.02544
0.033268
0.031311
0.117417
0.052838
0
0
0.005871
0
34,532
A
C
T
G
C
C
A
C
T
T
C
C
G
G
C
A
C
C
G
C
G
G
G
G
C
C
C
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G
G
G
C
T
C
C
G
G
C
G
C
G
C
C
C
G
G
T
G
A
C
G
G
C
G
G
A
G
A
G
G
C
G
C
C
C
C
0.007828
0.007828
0.019569
0.007828
0.005871
0.037182
0.021526
0.015656
0.015656
0.02544
0.037182
0.001957
0.003914
0.013699
0.011742
0.031311
0.029354
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0.1409
0.123288
0.019569
0.074364
0.011742
0.033268
0.019569
0.035225
0.029354
0.11546
0.04501
0.005871
0.003914
0.011742
0
34,533
G
C
A
G
G
C
C
A
G
G
G
C
A
G
C
C
C
C
T
G
T
G
C
C
C
C
A
G
C
T
C
T
T
G
C
C
C
A
G
C
A
G
G
C
A
A
C
C
A
C
C
A
G
G
C
G
C
T
G
G
G
T
T
G
T
C
0.007828
0.015656
0.027397
0.003914
0.017613
0.050881
0.009785
0.007828
0.027397
0.052838
0.07045
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0.011742
0.013699
0.02544
0.043053
0.091977
0.091977
0.09589
0.019569
0.013699
0.015656
0.003914
0.035225
0.019569
0.019569
0.052838
0.097847
0.033268
0.007828
0.001957
0.011742
0
34,534
C
T
G
G
G
T
G
A
C
G
G
C
C
T
G
A
G
C
G
C
C
C
T
C
T
G
C
C
T
C
C
C
C
G
G
C
C
T
G
C
T
C
C
T
T
C
T
G
C
T
G
C
A
G
G
A
T
G
G
A
G
G
C
G
T
T
0.013699
0.019569
0.023483
0.003914
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0.033268
0.017613
0.02544
0.031311
0.043053
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0.023483
0.054795
0.072407
0.064579
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0.011742
0.019569
0.011742
0.058708
0.019569
0.02544
0.046967
0.078278
0.046967
0.005871
0.003914
0.029354
0
34,535
A
G
A
C
T
T
C
A
T
C
T
A
T
A
T
A
T
G
C
A
T
C
T
A
C
C
A
A
G
A
T
C
C
G
T
T
T
T
C
A
G
G
G
T
T
A
A
T
A
T
T
C
T
G
T
G
G
T
C
A
A
A
A
T
A
T
0.056751
0.02544
0.031311
0.02544
0.02544
0.02544
0.011742
0.029354
0.048924
0.048924
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0.033268
0.033268
0.062622
0.052838
0.056751
0.007828
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0.056751
0.029354
0.019569
0.033268
0.033268
0.039139
0.013699
0.019569
0.039139
0
34,536
C
A
G
C
G
G
T
A
G
G
C
C
G
C
C
C
T
C
C
C
C
T
G
C
C
T
C
C
T
T
G
C
C
G
C
G
G
C
T
G
C
C
C
T
C
G
C
C
C
T
T
C
A
G
C
C
C
A
G
C
C
A
G
G
C
T
0.003914
0.009785
0.037182
0.001957
0.011742
0.027397
0.017613
0.007828
0.017613
0.046967
0.07045
0
0.003914
0.005871
0.023483
0.023483
0.054795
0.033268
0.084149
0.093933
0.017613
0.066536
0.001957
0.048924
0.023483
0.029354
0.037182
0.123288
0.04501
0.003914
0.001957
0.02544
0
34,537
G
A
T
G
A
A
G
A
G
G
T
T
G
T
G
G
C
C
A
T
T
C
T
T
G
A
G
G
T
C
G
A
C
C
T
C
G
C
G
G
T
C
C
C
G
G
G
C
C
T
T
G
G
C
G
G
C
C
T
T
G
C
C
G
C
G
0.001957
0.009785
0.033268
0.001957
0.013699
0.023483
0.017613
0.005871
0.019569
0.050881
0.07045
0
0.003914
0.009785
0.021526
0.021526
0.054795
0.033268
0.072407
0.093933
0.021526
0.07045
0.001957
0.056751
0.023483
0.027397
0.043053
0.123288
0.050881
0.001957
0
0.019569
0
34,538
C
C
A
G
T
G
C
C
A
C
C
A
G
G
C
A
C
A
G
A
G
G
C
T
C
T
T
G
T
G
G
G
C
T
G
C
C
T
G
G
A
G
G
C
C
A
G
T
C
C
A
A
G
T
C
T
T
C
T
C
G
G
A
A
G
A
0.001957
0.003914
0.023483
0.001957
0.023483
0.037182
0.005871
0.017613
0.037182
0.050881
0.072407
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0.005871
0.007828
0.013699
0.048924
0.093933
0.064579
0.107632
0.029354
0.011742
0.023483
0.013699
0.046967
0.009785
0.029354
0.060665
0.099804
0.029354
0.003914
0.005871
0.013699
0
34,539
G
C
T
C
G
G
G
C
A
C
A
C
G
T
G
C
T
T
G
G
A
G
T
G
C
T
G
C
C
T
C
C
C
C
A
G
G
G
A
C
G
G
C
G
T
C
T
G
C
A
G
C
G
A
C
A
G
G
G
T
C
G
G
G
A
G
0.003914
0.005871
0.035225
0.007828
0.013699
0.031311
0.017613
0.021526
0.021526
0.04501
0.058708
0
0.009785
0.013699
0.015656
0.027397
0.046967
0.04501
0.121331
0.060665
0.029354
0.041096
0.009785
0.056751
0.02544
0.039139
0.027397
0.07045
0.062622
0.009785
0.007828
0.017613
0
34,540
A
G
G
G
T
C
C
C
A
G
C
T
A
C
T
C
A
C
G
T
G
G
G
G
C
A
C
G
C
T
G
C
C
G
G
A
G
T
C
G
G
C
C
A
G
C
C
T
G
G
G
T
G
T
C
G
C
T
G
T
G
G
G
A
A
T
0.021526
0.023483
0.029354
0.007828
0.031311
0.04501
0.017613
0.02544
0.029354
0.029354
0.064579
0.009785
0.015656
0.013699
0.021526
0.056751
0.064579
0.076321
0.09002
0.015656
0.007828
0.009785
0.011742
0.043053
0.02544
0.035225
0.021526
0.056751
0.054795
0.003914
0.013699
0.027397
0
34,541
A
G
A
C
C
T
T
G
T
T
C
C
C
C
A
C
C
C
C
T
C
C
C
A
G
C
C
T
G
G
C
C
T
G
G
G
A
C
C
T
G
C
T
G
C
T
G
C
T
C
C
A
G
C
C
A
T
G
T
C
C
A
T
G
A
C
0.003914
0.009785
0.021526
0.005871
0.021526
0.033268
0.001957
0.029354
0.029354
0.041096
0.076321
0.007828
0.011742
0.035225
0.013699
0.02544
0.086106
0.078278
0.076321
0.019569
0.003914
0.021526
0.013699
0.056751
0.015656
0.033268
0.035225
0.082192
0.058708
0.017613
0.007828
0.02544
0
34,542
G
G
C
G
C
G
G
G
T
G
C
C
A
G
C
T
G
C
G
G
T
T
G
T
G
G
G
G
G
A
G
C
C
C
G
C
G
G
G
G
T
C
T
C
G
G
T
C
G
A
G
C
T
T
T
C
C
C
G
A
C
T
G
C
G
T
0.023483
0.013699
0.013699
0.007828
0.009785
0.031311
0.029354
0.007828
0.015656
0.041096
0.029354
0
0.013699
0.009785
0.017613
0.027397
0.04501
0.039139
0.123288
0.09589
0.031311
0.097847
0.001957
0.035225
0.015656
0.033268
0.043053
0.091977
0.041096
0.003914
0.001957
0.007828
0
34,543
T
G
A
G
C
C
G
G
G
C
A
C
G
G
A
G
C
C
G
G
G
C
A
T
A
G
A
T
G
G
T
A
C
G
G
A
G
G
C
C
C
T
G
C
A
G
C
T
G
C
C
G
C
G
C
A
G
C
C
A
G
T
G
C
A
T
0.009785
0.005871
0.019569
0.003914
0.031311
0.037182
0.013699
0.017613
0.031311
0.046967
0.052838
0.005871
0.017613
0.019569
0.011742
0.050881
0.074364
0.060665
0.09002
0.046967
0.007828
0.04501
0.009785
0.04501
0.005871
0.031311
0.048924
0.078278
0.04501
0.011742
0.007828
0.015656
0
34,544
A
G
C
C
C
C
C
C
A
C
A
G
A
G
C
C
C
C
C
C
G
A
G
C
C
C
G
A
C
A
A
C
C
C
C
A
C
C
T
G
G
T
C
G
A
C
T
C
A
G
C
C
C
A
C
G
T
A
T
A
G
C
A
A
C
T
0.019569
0.021526
0.011742
0.003914
0.031311
0.050881
0.017613
0.015656
0.011742
0.048924
0.060665
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0.013699
0.019569
0.062622
0.064579
0.056751
0.11546
0.039139
0.015656
0.021526
0.003914
0.054795
0.011742
0.02544
0.048924
0.060665
0.04501
0.007828
0.005871
0.023483
0
34,545
G
C
G
C
C
G
G
C
T
C
G
C
C
C
T
C
G
G
C
G
C
G
G
C
A
G
A
G
G
A
A
G
C
G
G
A
C
G
T
C
T
T
C
G
C
C
C
G
C
G
G
T
G
G
C
C
G
T
G
A
C
G
C
G
C
T
0.003914
0.017613
0.013699
0
0.015656
0.035225
0.050881
0.011742
0.013699
0.041096
0.027397
0
0.011742
0
0.013699
0.052838
0.046967
0.037182
0.060665
0.099804
0.037182
0.121331
0.007828
0.02544
0.017613
0.039139
0.048924
0.097847
0.031311
0.007828
0
0.011742
0
34,546
A
T
G
T
G
C
T
G
C
T
C
C
A
T
G
C
T
G
G
T
G
C
T
G
C
T
C
T
A
C
T
A
T
T
T
C
T
A
C
G
A
T
C
T
C
C
T
C
G
G
T
G
C
G
C
G
G
C
C
C
C
G
G
G
C
C
0.007828
0.005871
0.017613
0.001957
0.023483
0.033268
0.035225
0.011742
0.023483
0.035225
0.046967
0.001957
0.017613
0.021526
0.007828
0.056751
0.054795
0.043053
0.103718
0.074364
0.023483
0.043053
0.007828
0.037182
0.017613
0.027397
0.054795
0.097847
0.033268
0.013699
0
0.019569
0
34,547
G
G
G
C
A
G
A
C
T
C
A
C
C
T
G
C
A
C
T
T
G
C
C
G
A
A
G
G
G
C
A
G
C
C
G
C
C
G
C
A
C
A
C
A
G
G
G
C
G
C
C
A
G
G
C
A
G
C
T
G
T
A
G
A
G
A
0.005871
0.001957
0.009785
0.007828
0.019569
0.027397
0.021526
0.015656
0.023483
0.043053
0.056751
0.009785
0.019569
0.021526
0.013699
0.054795
0.068493
0.052838
0.093933
0.052838
0.011742
0.050881
0.017613
0.043053
0.005871
0.015656
0.066536
0.109589
0.027397
0.011742
0
0.019569
0
34,548
C
T
C
A
G
A
A
G
C
C
G
C
A
G
C
A
G
T
C
A
T
G
A
C
C
A
A
G
A
G
G
A
C
C
G
G
G
T
G
C
C
C
T
G
G
T
G
C
C
C
A
C
A
C
C
C
T
G
G
G
C
C
T
C
G
T
0.007828
0.009785
0.019569
0.001957
0.02544
0.035225
0.023483
0.019569
0.013699
0.04501
0.062622
0.001957
0.009785
0.017613
0.013699
0.054795
0.076321
0.074364
0.093933
0.04501
0.011742
0.02544
0
0.046967
0.015656
0.033268
0.041096
0.088063
0.058708
0.005871
0
0.021526
0
34,549
T
C
T
T
C
C
T
T
C
T
G
C
C
A
G
T
T
A
A
A
C
G
T
G
C
C
G
T
G
G
C
T
C
C
A
A
T
A
C
A
C
A
C
C
A
A
A
G
C
C
A
A
G
C
G
T
A
C
T
T
G
G
C
T
G
G
0.033268
0.015656
0.035225
0.017613
0.023483
0.019569
0.02544
0.027397
0.021526
0.048924
0.050881
0.011742
0.017613
0.015656
0.031311
0.04501
0.064579
0.064579
0.054795
0.02544
0.009785
0.02544
0.005871
0.043053
0.027397
0.021526
0.037182
0.076321
0.04501
0.013699
0.011742
0.033268
0
34,550
C
C
C
C
C
A
T
G
C
G
G
G
A
G
C
C
T
G
G
G
A
G
C
C
C
A
G
C
T
G
A
A
T
C
C
G
A
G
G
G
C
C
G
G
G
A
C
C
A
G
G
C
C
C
A
G
C
C
G
T
C
C
C
C
G
C
0.007828
0.007828
0.011742
0.003914
0.023483
0.029354
0.021526
0.009785
0.037182
0.046967
0.054795
0
0.013699
0.017613
0.011742
0.033268
0.074364
0.064579
0.107632
0.054795
0.015656
0.041096
0.007828
0.054795
0.009785
0.037182
0.037182
0.091977
0.052838
0.005871
0.001957
0.011742
0
34,551
G
G
A
C
G
A
C
A
A
G
G
C
T
G
G
T
G
G
C
C
A
C
C
A
C
G
C
C
A
A
T
G
C
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G
G
C
C
G
C
T
C
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A
C
A
G
C
A
C
G
C
G
G
C
A
T
C
C
A
G
A
G
C
G
G
0.023483
0.015656
0.041096
0.007828
0.037182
0.029354
0.02544
0.027397
0.029354
0.043053
0.043053
0.009785
0.017613
0.027397
0.033268
0.054795
0.050881
0.064579
0.052838
0.023483
0.013699
0.031311
0.015656
0.035225
0.021526
0.037182
0.035225
0.058708
0.043053
0.011742
0.009785
0.029354
0
34,552
T
G
G
C
A
G
C
C
G
G
G
A
G
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T
G
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G
A
G
G
G
C
T
G
G
T
C
A
G
C
T
C
C
A
G
C
T
0.015656
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0
34,553
C
T
G
G
A
A
A
T
G
G
C
G
T
C
T
G
T
C
C
C
C
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A
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G
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G
C
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C
A
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A
G
G
T
T
G
A
G
T
T
G
G
C
A
G
G
T
T
G
G
T
0.02544
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0.060665
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0
34,554
G
C
G
C
G
T
G
C
C
G
T
C
C
G
G
G
G
G
T
C
G
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C
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A
T
G
G
G
A
C
G
C
A
C
C
A
G
G
C
G
G
C
T
G
C
T
0
0.003914
0.011742
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0.007828
0.027397
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0.005871
0.019569
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0
0.011742
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0.011742
0.027397
0.054795
0.099804
0.027397
0.013699
0
0.009785
0
34,555
T
C
A
C
G
G
T
G
A
G
T
C
G
G
G
C
C
T
C
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C
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C
T
G
G
G
C
C
G
G
T
G
T
T
T
G
T
C
A
A
C
T
0.021526
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0.035225
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0.02544
0.013699
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0.037182
0.076321
0.048924
0.001957
0.001957
0.033268
0
34,556
C
T
G
A
G
C
G
C
T
G
A
G
C
T
G
T
G
C
A
G
G
A
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A
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T
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A
C
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T
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A
C
A
A
A
C
A
C
C
G
G
C
C
C
A
G
G
T
G
C
C
C
T
0.023483
0.019569
0.019569
0.007828
0.035225
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0.023483
0.017613
0.021526
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0.07045
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0.019569
0.037182
0.039139
0.074364
0.04501
0.003914
0.001957
0.031311
0
34,557
T
C
A
A
A
A
G
C
C
C
C
T
G
G
G
G
G
T
C
T
T
C
A
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G
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A
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C
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A
T
C
C
C
C
C
A
T
C
T
T
C
T
C
T
G
A
T
A
C
0.054795
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0.058708
0.023483
0.031311
0.023483
0.005871
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0.04501
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0.021526
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0.009785
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0.046967
0.019569
0.02544
0.033268
0.039139
0.019569
0.029354
0.041096
0
34,558
T
C
C
A
T
G
C
C
A
T
G
C
A
G
T
A
G
C
C
T
T
C
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A
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A
A
G
G
G
A
T
G
C
C
T
T
T
T
G
G
C
T
C
A
T
0.056751
0.029354
0.056751
0.029354
0.029354
0.023483
0.007828
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0.043053
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0.050881
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0.023483
0.033268
0.041096
0.019569
0.033268
0.037182
0
34,559
T
C
A
G
A
A
A
G
A
C
T
C
G
A
A
A
T
T
G
T
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A
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C
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C
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A
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G
T
A
C
T
A
G
T
G
T
A
A
G
A
C
G
G
T
A
C
T
0.072407
0.027397
0.04501
0.046967
0.039139
0.023483
0.013699
0.033268
0.054795
0.019569
0.037182
0.019569
0.017613
0.041096
0.031311
0.033268
0.041096
0.035225
0.023483
0.003914
0.011742
0.009785
0.013699
0.04501
0.052838
0.021526
0.037182
0.017613
0.035225
0.02544
0.035225
0.035225
0
34,560
C
C
A
C
C
A
C
G
T
A
A
A
G
A
C
T
C
A
C
A
C
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C
G
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G
C
A
G
T
G
T
C
G
G
A
T
G
G
C
G
T
T
T
A
A
0.048924
0.019569
0.054795
0.019569
0.064579
0.019569
0.023483
0.031311
0.046967
0.027397
0.041096
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0.066536
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0.029354
0.02544
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0.009785
0.011742
0.04501
0.04501
0.039139
0.035225
0.02544
0.033268
0.013699
0.023483
0.043053
0
34,561
T
G
G
G
G
T
G
A
A
G
T
T
C
A
C
A
G
C
C
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C
C
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A
A
A
C
A
T
T
C
C
A
C
A
C
A
T
C
C
C
A
C
C
0.019569
0.013699
0.046967
0.019569
0.033268
0.035225
0.013699
0.033268
0.031311
0.02544
0.074364
0.005871
0.013699
0.035225
0.031311
0.054795
0.052838
0.041096
0.048924
0.007828
0
0.017613
0.003914
0.060665
0.033268
0.021526
0.04501
0.041096
0.04501
0.02544
0.015656
0.052838
0
34,562
T
C
T
T
G
G
C
C
T
T
C
A
C
G
A
G
C
A
G
C
C
T
C
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G
A
C
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G
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C
T
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G
T
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G
A
G
G
A
G
G
C
T
G
A
A
G
T
G
C
T
G
G
G
G
A
C
A
C
A
G
C
C
0.017613
0.011742
0.027397
0.007828
0.039139
0.017613
0.013699
0.02544
0.031311
0.050881
0.056751
0
0.005871
0.013699
0.023483
0.04501
0.07045
0.050881
0.088063
0.04501
0.009785
0.021526
0.009785
0.056751
0.019569
0.033268
0.035225
0.088063
0.046967
0.007828
0.001957
0.027397
0
34,563
G
G
G
C
A
G
C
A
C
A
G
C
C
G
G
C
C
C
C
C
G
G
C
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C
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C
G
T
T
T
T
C
G
G
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G
G
A
A
A
A
T
T
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G
A
G
T
G
A
A
C
A
A
G
A
A
C
A
C
C
C
C
T
T
0.060665
0.027397
0.046967
0.007828
0.029354
0.031311
0.021526
0.021526
0.064579
0.015656
0.048924
0.007828
0.009785
0.009785
0.02544
0.035225
0.048924
0.048924
0.086106
0.027397
0.015656
0.017613
0.007828
0.046967
0.046967
0.037182
0.027397
0.048924
0.046967
0.005871
0.009785
0.013699
0
34,564
C
T
G
G
G
A
A
G
C
C
T
G
G
T
A
C
A
A
C
C
T
G
C
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C
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C
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G
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C
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T
T
C
C
G
C
G
A
G
G
C
C
T
A
C
A
A
C
C
G
C
T
T
0.005871
0.009785
0.011742
0.001957
0.033268
0.04501
0.015656
0.015656
0.015656
0.046967
0.052838
0
0.013699
0.031311
0.011742
0.043053
0.082192
0.068493
0.107632
0.041096
0.013699
0.043053
0.011742
0.02544
0.011742
0.031311
0.04501
0.084149
0.031311
0.027397
0
0.021526
0
34,565
G
T
A
C
C
A
G
G
C
C
C
C
C
A
G
C
A
C
C
C
G
G
T
G
G
G
G
G
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G
C
G
C
G
C
T
G
T
G
G
A
A
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G
A
C
A
G
G
C
C
A
A
T
C
C
G
G
G
G
C
A
A
G
G
T
0.003914
0.011742
0.011742
0.005871
0.02544
0.050881
0.015656
0.015656
0.007828
0.035225
0.064579
0.001957
0.011742
0.019569
0.017613
0.052838
0.064579
0.062622
0.123288
0.052838
0.013699
0.031311
0.017613
0.031311
0.011742
0.023483
0.048924
0.09002
0.039139
0.019569
0
0.017613
0
34,566
T
G
T
G
C
T
C
G
C
C
T
G
G
C
T
C
C
T
C
C
G
C
A
T
G
C
G
G
C
C
G
G
C
G
C
C
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C
T
C
C
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G
G
G
T
G
C
C
C
A
G
G
T
G
G
A
A
T
A
G
C
A
G
T
T
0.005871
0.009785
0.015656
0.001957
0.021526
0.041096
0.029354
0.015656
0.023483
0.062622
0.041096
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0.007828
0.011742
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0.068493
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0.072407
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0.043053
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0.039139
0.017613
0.027397
0.060665
0.080235
0.035225
0.001957
0
0.017613
0
34,567
A
G
T
C
A
G
C
T
C
A
G
G
A
T
T
C
A
G
A
G
A
C
A
G
C
T
C
C
C
A
A
A
T
C
A
A
A
T
C
C
T
A
T
T
C
A
A
G
A
A
C
T
C
A
G
A
C
C
A
G
C
T
C
A
G
C
0.017613
0.031311
0.019569
0.023483
0.021526
0.037182
0.003914
0.031311
0.048924
0.078278
0.021526
0.001957
0.033268
0.023483
0.029354
0.02544
0.093933
0.091977
0.048924
0.009785
0.007828
0.001957
0.019569
0.048924
0.037182
0.035225
0.02544
0.023483
0.064579
0.001957
0.007828
0.033268
0
34,568
T
G
T
C
G
G
A
A
C
T
A
G
A
C
A
G
G
G
C
T
G
T
G
G
A
G
C
T
T
A
A
T
T
C
T
A
T
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G
C
T
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C
G
A
T
G
G
C
C
T
G
G
G
T
C
C
C
A
G
G
A
C
T
A
C
0.019569
0.023483
0.029354
0.029354
0.017613
0.031311
0
0.027397
0.050881
0.109589
0.027397
0.007828
0.013699
0.005871
0.029354
0.011742
0.111546
0.084149
0.035225
0.003914
0.009785
0.009785
0.023483
0.050881
0.039139
0.035225
0.029354
0.035225
0.050881
0.005871
0.013699
0.027397
0
34,569
C
T
C
T
G
A
G
A
C
C
G
G
G
C
T
C
A
G
C
T
C
T
G
A
A
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C
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A
C
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C
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C
A
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T
T
C
A
G
C
C
C
A
G
C
C
C
T
G
G
A
G
C
C
C
T
0.011742
0.035225
0.019569
0.023483
0.005871
0.041096
0
0.029354
0.058708
0.078278
0.035225
0
0.013699
0.005871
0.021526
0.011742
0.111546
0.084149
0.084149
0.017613
0.001957
0
0.013699
0.054795
0.050881
0.029354
0.011742
0.054795
0.041096
0
0.005871
0.046967
0
34,570
T
C
T
A
G
G
G
T
C
A
A
G
G
C
C
A
G
G
G
G
T
C
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A
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G
C
T
C
A
G
C
C
A
G
A
T
T
C
T
T
G
A
A
C
G
0.011742
0.033268
0.023483
0.019569
0.011742
0.041096
0.001957
0.023483
0.052838
0.056751
0.04501
0.001957
0.019569
0.013699
0.02544
0.015656
0.097847
0.09002
0.099804
0.015656
0.001957
0
0.013699
0.043053
0.04501
0.023483
0.009785
0.074364
0.035225
0.005871
0.005871
0.041096
0
34,571
G
G
C
T
G
A
C
A
G
C
T
C
T
C
C
C
C
T
T
T
G
C
A
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C
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C
T
G
C
G
A
A
A
C
C
C
G
C
C
T
G
C
C
A
T
T
0.021526
0.011742
0.017613
0.013699
0.019569
0.033268
0.013699
0.017613
0.029354
0.058708
0.050881
0.007828
0.019569
0.009785
0.017613
0.031311
0.078278
0.048924
0.076321
0.048924
0.011742
0.046967
0.005871
0.054795
0.017613
0.031311
0.04501
0.060665
0.056751
0.009785
0.007828
0.02544
0
34,572
G
C
T
C
T
C
T
C
C
T
C
C
C
A
G
C
C
T
G
G
A
G
C
C
T
G
A
G
G
A
C
G
C
G
G
C
G
C
C
C
A
C
C
C
C
G
C
C
C
G
G
G
C
C
C
T
C
C
T
C
G
G
A
G
G
T
0.001957
0.007828
0.005871
0
0.009785
0.023483
0.043053
0.007828
0.015656
0.056751
0.064579
0
0.011742
0.011742
0.005871
0.029354
0.066536
0.039139
0.072407
0.072407
0.027397
0.084149
0.003914
0.068493
0.007828
0.035225
0.046967
0.088063
0.062622
0.011742
0
0.017613
0
34,573
C
C
A
G
T
G
G
G
C
T
C
G
C
C
G
G
C
G
A
C
G
G
C
G
C
G
C
A
C
G
C
T
C
G
T
G
G
T
C
T
C
C
T
A
G
C
T
C
C
T
C
A
G
C
A
T
C
C
A
G
C
T
C
C
G
T
0
0.003914
0.029354
0.001957
0.007828
0.015656
0.015656
0.019569
0.041096
0.074364
0.052838
0
0.021526
0.023483
0.009785
0.027397
0.072407
0.043053
0.056751
0.050881
0.017613
0.064579
0.007828
0.078278
0.021526
0.021526
0.054795
0.074364
0.056751
0.005871
0.001957
0.027397
0
34,574
G
G
C
C
T
C
C
A
G
A
G
A
T
C
G
C
A
A
T
G
C
C
A
A
A
G
C
C
C
C
G
G
C
G
G
G
G
G
T
C
C
T
G
A
G
A
G
A
G
G
A
T
G
A
G
G
G
G
A
A
G
G
A
A
G
T
0.011742
0.015656
0.019569
0.003914
0.02544
0.039139
0.011742
0.021526
0.039139
0.037182
0.062622
0.007828
0.02544
0.02544
0.017613
0.043053
0.066536
0.066536
0.078278
0.033268
0.009785
0.015656
0.005871
0.068493
0.019569
0.02544
0.02544
0.07045
0.052838
0.013699
0.003914
0.037182
0
34,575
C
T
A
T
G
A
A
C
G
G
G
A
A
G
C
C
C
T
G
A
A
G
A
A
A
A
A
G
T
T
T
A
T
G
C
G
A
G
T
A
C
A
T
G
A
T
G
C
G
G
A
G
T
C
C
T
C
C
G
A
T
G
A
A
G
C
0.027397
0.021526
0.043053
0.011742
0.029354
0.035225
0.007828
0.02544
0.033268
0.039139
0.066536
0.02544
0.021526
0.031311
0.013699
0.035225
0.056751
0.043053
0.056751
0.02544
0.011742
0.005871
0.02544
0.041096
0.04501
0.027397
0.029354
0.043053
0.056751
0.013699
0.017613
0.033268
0