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int64
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string
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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G
G
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A
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C
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C
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C
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T
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A
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A
T
A
G
G
G
A
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G
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G
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C
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T
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A
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C
C
C
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T
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C
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C
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C
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C
T
T
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C
A
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A
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C
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35,482
T
G
T
G
C
A
G
C
C
T
C
T
G
A
T
G
G
A
C
T
T
G
A
A
G
C
A
C
T
G
A
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C
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G
T
A
A
C
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A
A
G
C
C
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T
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35,483
A
G
C
A
T
C
T
A
C
G
C
C
G
T
G
T
T
T
T
C
C
A
A
T
T
G
A
G
A
A
T
T
T
C
C
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G
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A
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A
G
T
C
T
A
C
A
A
G
G
G
G
A
T
G
G
G
C
T
T
A
T
C
G
C
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35,484
T
C
A
G
T
T
T
A
C
A
A
G
A
A
C
T
C
A
A
A
C
A
A
A
A
G
A
T
A
A
A
T
C
C
T
A
T
G
G
A
T
T
T
A
G
T
G
A
C
C
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T
A
T
T
C
A
A
T
C
T
T
T
T
T
G
0.101761
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0
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35,485
G
T
G
G
A
C
T
T
C
A
C
A
C
G
G
G
A
G
G
A
A
C
A
G
G
G
T
A
C
T
T
G
C
A
A
C
C
C
T
G
C
T
C
A
G
A
G
G
A
C
C
C
T
G
G
A
C
A
G
A
G
A
T
G
T
G
0.064579
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0
35,486
T
G
G
A
G
T
G
C
A
G
T
G
A
C
A
C
A
A
T
C
C
T
A
G
C
T
C
A
C
T
G
C
C
G
C
C
T
C
A
A
A
C
T
T
C
T
G
G
G
C
T
C
A
A
G
C
C
A
T
C
C
T
C
C
T
T
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35,487
G
C
A
G
G
A
T
G
A
G
A
A
G
C
C
C
C
C
A
G
A
G
C
C
C
C
C
G
A
A
G
G
T
C
T
G
T
G
C
A
C
A
G
G
T
G
A
G
T
G
G
A
G
A
C
C
C
A
G
A
G
C
T
T
G
C
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0
35,488
C
A
C
T
T
T
T
T
C
T
A
G
A
A
A
G
C
C
T
G
A
G
T
C
C
T
G
A
G
T
A
T
C
G
C
A
A
T
A
T
A
T
C
C
C
A
G
C
T
T
C
A
G
G
G
A
C
G
G
A
T
C
A
G
A
T
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0
35,489
T
A
T
C
C
C
T
G
T
G
T
T
A
C
C
G
T
C
T
G
G
C
A
T
T
T
C
T
G
A
T
G
C
A
G
A
G
A
A
A
A
T
A
G
C
C
C
A
G
T
T
C
T
G
A
G
G
C
C
A
C
A
G
C
A
T
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0
35,490
G
A
T
G
A
T
C
A
G
C
A
C
C
A
T
A
G
A
G
G
C
A
G
A
G
C
T
C
A
A
C
T
C
C
A
G
C
C
T
G
A
C
C
C
T
G
C
A
G
T
G
T
T
G
G
G
C
C
G
A
G
T
C
C
A
T
0.02544
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0
35,491
C
T
T
G
G
A
C
A
G
C
T
G
C
A
T
G
C
G
C
T
C
A
T
G
G
A
A
C
A
C
A
A
T
G
G
A
G
A
G
G
T
T
G
T
T
G
G
A
A
A
C
C
C
A
G
T
G
G
A
T
G
G
T
A
A
C
0.013699
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0.037182
0
35,492
C
C
A
G
C
T
C
A
C
C
C
T
C
A
A
T
G
C
C
A
A
C
C
C
A
C
T
T
G
A
T
G
C
C
A
C
C
C
A
A
A
G
T
G
A
G
G
A
T
G
T
T
G
T
T
C
T
G
C
C
T
G
T
G
T
T
0.027397
0.031311
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0.023483
0.031311
0.031311
0.041096
0.04501
0.017613
0.007828
0.039139
0
35,493
G
G
T
C
C
T
G
C
A
G
G
G
T
G
A
G
G
C
C
G
G
G
G
C
T
G
C
A
G
A
C
G
C
G
A
C
T
G
T
A
C
A
G
G
T
C
T
A
T
G
A
A
G
A
C
C
C
C
A
T
G
T
G
T
G
T
0.011742
0.013699
0.031311
0.005871
0.033268
0.048924
0.017613
0.023483
0.043053
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0.046967
0.064579
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0.072407
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0.009785
0.058708
0.02544
0.046967
0.031311
0.033268
0.052838
0.015656
0.007828
0.039139
0
35,494
C
T
G
C
T
C
C
G
T
C
A
C
A
C
T
C
C
T
G
T
G
T
C
C
C
C
T
G
C
T
G
G
T
T
T
C
C
A
G
C
A
C
G
A
C
G
G
T
G
T
A
G
C
T
G
C
C
C
G
A
G
T
C
C
T
C
0.019569
0.02544
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0.041096
0.033268
0.041096
0.04501
0.003914
0.011742
0.041096
0
35,495
C
T
A
C
A
A
C
A
T
C
T
C
T
G
T
T
C
A
A
G
G
G
A
A
C
A
A
C
C
C
A
A
C
G
T
A
A
C
C
A
G
A
C
T
C
C
C
T
T
T
G
C
C
C
T
G
T
T
T
C
T
G
A
A
A
T
0.097847
0.031311
0.039139
0.02544
0.056751
0.029354
0.015656
0.013699
0.058708
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0.052838
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0.005871
0.001957
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0.041096
0.043053
0.017613
0.033268
0.021526
0.037182
0.021526
0.011742
0.023483
0
35,496
G
A
C
G
G
C
C
A
T
G
C
T
G
C
C
A
G
A
T
T
C
A
C
C
A
T
G
C
C
G
C
G
C
C
C
A
A
G
T
C
A
G
C
T
G
T
G
A
C
A
C
A
T
G
C
G
T
C
A
C
C
T
C
C
A
T
0.007828
0.021526
0.019569
0.009785
0.019569
0.035225
0.039139
0.015656
0.023483
0.043053
0.046967
0.007828
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0.021526
0.021526
0.048924
0.060665
0.056751
0.076321
0.041096
0.019569
0.04501
0.015656
0.033268
0.031311
0.031311
0.054795
0.060665
0.046967
0.007828
0
0.021526
0
35,497
T
G
G
G
G
A
G
C
G
C
T
C
C
A
C
T
G
A
T
T
G
T
G
T
C
T
C
T
G
C
A
C
T
C
G
T
T
G
G
G
G
G
C
C
C
T
G
C
C
C
C
C
A
G
C
C
G
G
G
G
C
C
C
G
C
G
0.017613
0.017613
0.02544
0.007828
0.019569
0.037182
0.013699
0.02544
0.056751
0.031311
0.050881
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0.009785
0.017613
0.052838
0.046967
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0.103718
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0.021526
0.02544
0.013699
0.078278
0.027397
0.023483
0.037182
0.050881
0.050881
0.001957
0.005871
0.019569
0
35,498
G
A
G
C
C
G
G
G
G
C
A
G
C
T
G
T
G
G
A
C
A
T
G
C
C
C
C
T
T
G
C
A
C
A
C
G
T
G
T
G
T
C
C
G
C
G
G
G
C
T
G
G
T
T
G
C
A
G
G
C
G
A
G
T
G
T
0.019569
0.013699
0.017613
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0.027397
0.031311
0.02544
0.02544
0.029354
0.04501
0.043053
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0.007828
0.023483
0.017613
0.064579
0.054795
0.048924
0.054795
0.050881
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0.076321
0.005871
0.064579
0.015656
0.021526
0.052838
0.064579
0.04501
0.007828
0.001957
0.031311
0
35,499
G
C
T
C
C
T
C
T
G
C
C
A
C
C
A
C
C
T
C
A
G
T
C
A
C
T
C
A
C
C
G
G
T
G
C
C
G
A
A
G
T
G
G
A
A
G
A
C
A
T
G
G
C
G
C
T
T
G
T
T
C
C
C
G
T
C
0.005871
0.009785
0.02544
0.001957
0.015656
0.035225
0.029354
0.023483
0.033268
0.043053
0.054795
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0.017613
0.017613
0.017613
0.052838
0.064579
0.060665
0.082192
0.041096
0.011742
0.027397
0.005871
0.058708
0.019569
0.037182
0.035225
0.074364
0.046967
0.003914
0
0.041096
0
35,500
A
G
G
C
C
C
G
G
C
T
G
G
G
C
G
C
G
G
A
C
A
T
G
G
A
G
G
A
C
G
T
G
T
G
C
G
G
C
C
G
C
C
T
G
G
T
G
C
A
G
T
A
C
C
G
C
G
G
C
G
A
G
G
T
G
C
0.001957
0.009785
0.015656
0.001957
0.019569
0.027397
0.013699
0.013699
0.023483
0.039139
0.060665
0
0.015656
0.02544
0.011742
0.033268
0.056751
0.048924
0.066536
0.066536
0.027397
0.099804
0.001957
0.064579
0.013699
0.019569
0.04501
0.101761
0.046967
0.011742
0.001957
0.013699
0
35,501
G
G
C
T
C
C
T
C
C
G
C
G
A
T
G
C
C
G
A
T
G
A
C
C
T
G
C
A
G
A
A
G
C
G
C
C
T
G
G
C
A
G
T
G
T
A
C
C
A
G
G
C
C
G
G
G
G
C
C
C
G
C
G
A
G
T
0.001957
0.007828
0.011742
0.001957
0.017613
0.031311
0.013699
0.009785
0.007828
0.050881
0.064579
0
0.011742
0.017613
0.009785
0.033268
0.064579
0.050881
0.048924
0.078278
0.02544
0.121331
0.003914
0.050881
0.009785
0.017613
0.048924
0.11546
0.048924
0.013699
0.001957
0.007828
0
35,502
A
G
C
A
T
G
C
C
A
G
C
C
A
G
A
G
G
C
C
C
A
G
G
A
A
G
G
A
A
C
C
C
T
G
A
G
C
C
C
C
C
C
A
C
C
A
A
A
G
C
T
A
A
A
G
A
T
G
A
G
T
C
G
C
T
C
0.050881
0.015656
0.029354
0.003914
0.017613
0.050881
0.001957
0.017613
0.039139
0.039139
0.082192
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0.011742
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0.066536
0.066536
0.101761
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0.019569
0.064579
0.023483
0.031311
0.023483
0.04501
0.060665
0.003914
0.015656
0.027397
0
35,503
C
T
A
T
G
A
C
G
A
C
C
A
C
C
T
G
A
G
G
G
A
C
C
T
G
G
G
T
C
C
G
C
T
C
A
C
C
A
A
G
G
C
C
T
G
G
T
T
C
C
T
C
G
A
A
T
C
C
A
A
A
G
A
C
A
G
0.039139
0.021526
0.029354
0.005871
0.037182
0.046967
0.001957
0.019569
0.043053
0.043053
0.078278
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0.013699
0.017613
0.019569
0.037182
0.062622
0.052838
0.07045
0.011742
0.013699
0.007828
0.021526
0.07045
0.02544
0.035225
0.015656
0.043053
0.054795
0.011742
0.011742
0.031311
0
35,504
A
G
G
C
C
C
G
C
C
T
C
A
G
G
T
C
A
G
G
G
C
C
C
A
G
C
G
T
G
T
G
A
T
G
T
A
G
G
G
G
C
C
G
G
G
G
C
A
G
G
C
C
A
G
G
G
T
T
T
G
T
T
T
G
T
C
0.017613
0.013699
0.017613
0.003914
0.031311
0.031311
0.017613
0.011742
0.021526
0.035225
0.074364
0
0.019569
0.015656
0.015656
0.037182
0.064579
0.058708
0.123288
0.037182
0.017613
0.029354
0.013699
0.046967
0.013699
0.033268
0.023483
0.088063
0.052838
0.007828
0.005871
0.019569
0
35,505
G
G
G
A
G
A
C
C
C
G
G
C
C
T
C
A
G
C
T
G
G
G
G
C
C
T
C
T
T
C
A
A
T
G
T
C
G
C
C
G
T
C
C
G
C
G
C
C
C
G
G
C
A
C
G
G
G
C
G
G
C
G
C
C
T
C
0.003914
0.003914
0.013699
0.011742
0.011742
0.021526
0.027397
0.007828
0.021526
0.039139
0.039139
0.007828
0.017613
0.019569
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0.019569
0.02544
0.027397
0.101761
0.105675
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0.015656
0.054795
0.011742
0.039139
0.02544
0.099804
0.050881
0.005871
0.001957
0.015656
0
35,506
C
G
A
G
A
A
C
C
A
T
T
T
T
A
A
A
G
A
G
G
G
G
G
A
A
A
C
T
G
A
G
G
T
C
C
A
C
A
A
C
A
G
G
C
A
G
G
G
G
C
T
T
G
C
C
T
G
G
G
G
T
C
A
C
A
C
0.011742
0.015656
0.021526
0.005871
0.023483
0.04501
0.007828
0.013699
0.023483
0.043053
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0.054795
0.131115
0.041096
0.007828
0.013699
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0.048924
0.013699
0.027397
0.041096
0.093933
0.027397
0.005871
0.007828
0.035225
0
35,507
T
T
G
C
C
C
T
G
A
G
G
C
A
C
G
G
C
C
C
G
A
C
G
G
G
G
G
C
G
C
C
C
T
G
G
A
G
G
C
G
C
T
G
T
T
G
G
C
C
C
G
G
T
G
G
G
C
A
G
C
G
T
G
G
G
C
0.001957
0.011742
0.029354
0.007828
0.011742
0.037182
0.021526
0.013699
0.015656
0.04501
0.052838
0.005871
0.011742
0.021526
0.02544
0.037182
0.054795
0.068493
0.09002
0.052838
0.02544
0.060665
0.005871
0.037182
0.019569
0.031311
0.039139
0.097847
0.041096
0.003914
0.003914
0.017613
0
35,508
G
T
G
C
C
T
G
G
A
G
G
A
C
C
G
G
C
A
G
C
A
G
A
C
C
G
G
G
G
G
C
G
C
G
C
C
C
G
A
G
G
G
C
C
G
C
G
C
G
C
G
C
C
T
C
T
G
G
G
A
C
G
T
T
T
A
0.005871
0.015656
0.017613
0
0.011742
0.035225
0.043053
0.013699
0.017613
0.056751
0.037182
0
0.007828
0.019569
0.017613
0.04501
0.064579
0.048924
0.050881
0.056751
0.037182
0.103718
0.001957
0.041096
0.015656
0.037182
0.064579
0.080235
0.027397
0.005871
0
0.019569
0
35,509
C
T
C
A
C
T
C
A
C
C
T
G
C
A
G
C
T
C
C
T
G
G
A
A
C
A
G
C
A
G
G
T
T
G
G
C
C
A
C
G
A
C
A
C
G
G
T
G
G
C
A
G
A
G
C
C
G
G
G
T
C
A
C
A
T
C
0.015656
0.02544
0.019569
0
0.027397
0.037182
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0.017613
0.035225
0.046967
0.064579
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0.07045
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0.015656
0.021526
0.035225
0.078278
0.043053
0.001957
0.009785
0.027397
0
35,510
C
G
G
C
A
G
A
G
G
A
G
G
G
T
G
C
C
T
C
T
G
G
T
C
C
C
A
G
G
T
C
A
C
A
C
G
G
C
C
A
A
C
C
G
G
G
A
G
C
T
C
T
G
G
G
C
C
A
G
G
G
G
A
T
C
T
0.011742
0.02544
0.017613
0.009785
0.033268
0.041096
0.007828
0.011742
0.04501
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0.113503
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0.021526
0.02544
0.019569
0.07045
0.054795
0.003914
0.007828
0.019569
0
35,511
G
G
G
G
G
G
T
C
G
G
G
G
C
T
C
A
C
C
C
T
G
C
A
G
C
A
C
T
T
C
G
T
C
G
G
G
C
A
G
C
A
C
G
G
G
G
T
T
G
G
C
C
A
G
G
T
G
G
G
C
G
T
C
C
G
T
0.005871
0.003914
0.017613
0.001957
0.011742
0.027397
0.033268
0.013699
0.027397
0.052838
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0.011742
0.011742
0.009785
0.037182
0.080235
0.048924
0.103718
0.056751
0.015656
0.058708
0.001957
0.046967
0.013699
0.035225
0.060665
0.086106
0.04501
0.007828
0
0.017613
0
35,512
T
C
A
C
T
G
T
C
T
T
G
T
C
T
T
C
T
G
G
C
T
C
G
A
A
G
G
T
T
T
C
T
T
T
C
C
C
T
T
T
G
G
G
C
T
T
C
T
T
C
C
T
C
T
T
C
T
T
G
G
T
G
G
T
G
G
0.052838
0.011742
0.058708
0.009785
0.035225
0.021526
0.009785
0.023483
0.068493
0.033268
0.058708
0
0.015656
0.021526
0.015656
0.041096
0.066536
0.058708
0.058708
0.009785
0.009785
0.003914
0.005871
0.052838
0.058708
0.035225
0.02544
0.046967
0.058708
0.001957
0.003914
0.02544
0
35,513
G
G
G
A
G
C
T
G
C
C
A
G
A
G
C
T
G
C
C
T
G
G
G
C
C
T
G
A
G
G
C
T
T
C
G
C
T
C
C
T
T
C
T
G
G
C
T
G
T
T
G
A
G
G
C
G
C
C
A
T
G
G
T
C
C
C
0.039139
0.009785
0.052838
0.005871
0.021526
0.017613
0.007828
0.021526
0.062622
0.052838
0.062622
0
0.017613
0.023483
0.021526
0.031311
0.068493
0.064579
0.054795
0.015656
0.007828
0.007828
0.005871
0.072407
0.046967
0.02544
0.021526
0.066536
0.056751
0.001957
0
0.035225
0
35,514
C
A
C
C
A
C
C
T
C
T
G
T
C
T
C
T
G
G
C
T
C
C
A
C
T
G
T
G
G
C
A
T
C
T
T
G
C
T
G
T
T
T
T
T
C
T
T
T
C
T
T
C
G
T
C
T
T
C
T
T
T
T
T
G
G
T
0.029354
0.007828
0.056751
0.005871
0.021526
0.017613
0.005871
0.021526
0.068493
0.054795
0.056751
0
0.021526
0.023483
0.019569
0.033268
0.072407
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0.046967
0.017613
0.007828
0.007828
0.005871
0.066536
0.050881
0.02544
0.02544
0.068493
0.056751
0.001957
0
0.033268
0
35,515
A
G
G
C
T
C
C
C
A
C
A
G
G
C
C
G
G
G
A
C
A
A
G
A
A
G
C
G
G
A
A
G
C
A
G
C
A
G
C
A
G
C
A
G
C
A
G
C
C
T
G
T
G
T
A
G
T
C
T
G
C
C
C
C
C
A
0.017613
0.011742
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0.066536
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0.007828
0.04501
0.050881
0.02544
0.039139
0.060665
0.050881
0.007828
0.007828
0.031311
0
35,516
A
C
C
A
C
C
T
T
G
G
T
C
T
C
C
T
T
G
G
C
C
C
A
G
T
C
C
C
A
C
A
C
C
G
A
G
A
G
C
A
T
G
T
G
A
T
C
A
T
T
G
G
A
T
T
C
A
T
C
C
A
C
T
G
C
T
0.029354
0.015656
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0.021526
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0.039139
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0.02544
0.035225
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0.003914
0.003914
0.013699
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0.011742
0.027397
0.037182
0.048924
0.048924
0.005871
0.021526
0.037182
0
35,517
T
G
T
G
T
G
C
A
G
T
G
G
A
T
G
A
A
T
C
C
A
A
T
G
A
T
C
A
C
A
T
G
C
T
C
T
C
G
G
T
G
T
G
G
G
A
C
T
G
G
G
C
C
A
A
G
G
A
G
A
C
C
A
A
G
T
0.033268
0.015656
0.037182
0.023483
0.035225
0.037182
0.001957
0.02544
0.035225
0.031311
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0.013699
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0.011742
0.027397
0.037182
0.048924
0.048924
0.005871
0.02544
0.035225
0
35,518
G
C
T
G
T
A
G
G
T
G
G
G
T
G
C
C
A
G
C
T
C
G
T
C
T
G
G
G
A
T
C
A
T
C
A
T
G
G
G
C
A
C
A
G
G
G
C
G
G
C
C
C
C
T
C
A
G
G
A
A
C
A
T
T
T
C
0.043053
0.015656
0.039139
0.015656
0.031311
0.02544
0.011742
0.015656
0.033268
0.054795
0.066536
0.013699
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0.017613
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0.039139
0.062622
0.056751
0.060665
0.013699
0.007828
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0.009785
0.058708
0.023483
0.021526
0.033268
0.058708
0.052838
0.007828
0.011742
0.033268
0
35,519
C
T
G
T
T
C
C
T
C
T
G
T
C
A
C
G
G
G
A
G
C
A
A
A
C
A
C
C
A
C
C
T
C
G
T
G
G
A
C
A
C
C
C
A
G
C
A
G
G
G
G
C
A
C
C
A
G
C
G
T
C
A
G
C
G
G
0.037182
0.013699
0.02544
0.031311
0.015656
0.027397
0.019569
0.007828
0.033268
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0.048924
0.078278
0.031311
0.017613
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0.056751
0.035225
0.015656
0.043053
0.052838
0.052838
0.003914
0.019569
0.029354
0
35,520
C
G
A
G
A
T
C
T
T
G
G
A
G
G
A
T
G
A
C
A
T
G
G
A
G
T
A
C
C
T
G
A
C
C
C
A
A
G
G
T
G
A
G
G
C
C
C
A
G
G
C
C
T
G
G
C
C
C
T
G
A
T
G
C
T
A
0.015656
0.013699
0.021526
0.011742
0.027397
0.027397
0.007828
0.023483
0.02544
0.052838
0.066536
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0.02544
0.017613
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0.076321
0.068493
0.078278
0.015656
0.007828
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0.02544
0.015656
0.037182
0.074364
0.048924
0.007828
0.003914
0.037182
0
35,521
C
C
C
C
T
C
A
G
G
G
T
C
G
G
G
G
T
C
T
G
G
C
A
G
C
C
T
C
A
G
C
A
C
G
G
T
G
T
G
G
G
G
G
G
C
C
T
G
T
G
T
C
C
C
C
A
G
C
C
C
C
T
T
T
T
T
0.007828
0.017613
0.023483
0.005871
0.027397
0.04501
0.011742
0.013699
0.02544
0.050881
0.068493
0
0.003914
0.009785
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0.048924
0.086106
0.062622
0.117417
0.029354
0.007828
0.02544
0.005871
0.043053
0.027397
0.031311
0.041096
0.07045
0.04501
0
0.001957
0.029354
0
35,522
C
C
G
C
C
G
C
T
G
C
C
A
C
C
A
C
C
T
C
C
A
G
C
A
C
C
A
G
C
C
T
G
C
C
C
T
T
C
T
C
C
C
C
T
G
A
C
T
C
C
C
C
T
G
G
C
C
T
C
C
T
G
C
C
C
T
0.005871
0.011742
0.019569
0
0.017613
0.041096
0.017613
0.007828
0.02544
0.050881
0.074364
0
0.011742
0.011742
0.009785
0.048924
0.088063
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0.039139
0.007828
0.02544
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0.04501
0.019569
0.023483
0.050881
0.093933
0.039139
0
0.001957
0.027397
0
35,523
A
C
A
G
T
G
A
G
G
T
C
C
C
A
G
G
C
C
C
C
A
C
A
C
C
C
A
T
G
G
A
A
C
T
G
G
A
G
G
C
C
G
A
G
C
A
G
C
T
G
C
T
T
G
A
G
C
C
A
C
A
C
G
T
G
G
0.013699
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0.029354
0.013699
0.023483
0.052838
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0.017613
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0.015656
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0.037182
0.029354
0.029354
0.046967
0.064579
0.013699
0.007828
0.019569
0
35,524
G
A
G
G
G
G
A
A
G
C
C
A
G
G
G
A
A
A
T
C
T
T
A
G
T
G
T
C
T
C
A
G
T
A
C
A
A
G
A
C
C
T
C
T
C
A
G
A
T
C
C
T
T
A
G
A
G
T
G
A
G
G
G
G
G
A
0.033268
0.015656
0.033268
0.013699
0.027397
0.023483
0.007828
0.02544
0.048924
0.037182
0.07045
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0.02544
0.017613
0.023483
0.037182
0.074364
0.046967
0.060665
0.019569
0.011742
0.007828
0.021526
0.050881
0.029354
0.021526
0.04501
0.082192
0.031311
0.009785
0.009785
0.035225
0
35,525
C
C
C
C
C
A
C
C
C
C
C
T
C
C
T
C
G
G
C
C
T
C
C
A
C
C
C
A
C
G
C
T
C
T
C
G
G
C
C
T
C
A
G
A
C
C
C
C
T
C
C
C
T
G
G
A
C
T
T
C
C
T
G
C
G
T
0.001957
0.007828
0.019569
0
0.009785
0.043053
0.009785
0.021526
0.017613
0.043053
0.07045
0
0.007828
0.007828
0.015656
0.054795
0.072407
0.082192
0.138943
0.041096
0.013699
0.021526
0.003914
0.056751
0.011742
0.019569
0.039139
0.103718
0.046967
0
0
0.017613
0
35,526
G
T
C
C
G
A
G
C
C
A
A
G
C
G
C
T
C
A
G
C
C
G
G
T
G
T
C
A
G
C
T
A
C
T
C
T
T
A
G
G
C
G
C
T
T
C
C
G
A
C
T
T
A
C
C
C
G
G
G
T
G
C
C
C
G
T
0.013699
0.007828
0.037182
0.007828
0.003914
0.023483
0.013699
0.017613
0.033268
0.029354
0.048924
0.005871
0.015656
0.02544
0.009785
0.021526
0.027397
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0.131115
0.076321
0.023483
0.078278
0.013699
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0.031311
0.02544
0.037182
0.074364
0.056751
0.003914
0.011742
0.009785
0
35,527
C
C
T
C
T
T
G
T
A
C
A
A
T
G
C
C
A
G
C
T
C
G
C
T
G
G
T
C
A
G
C
G
T
C
T
T
C
A
G
C
C
G
G
G
C
G
C
G
C
A
G
G
C
T
C
C
G
C
T
C
C
G
A
T
G
C
0.001957
0.001957
0.015656
0.003914
0.011742
0.029354
0.007828
0.005871
0.015656
0.056751
0.078278
0
0.009785
0.009785
0.009785
0.023483
0.066536
0.04501
0.091977
0.072407
0.021526
0.09002
0.007828
0.066536
0.005871
0.023483
0.033268
0.113503
0.050881
0.005871
0.005871
0.017613
0
35,528
C
G
T
C
C
C
C
T
C
G
G
C
C
A
G
T
C
A
A
G
G
C
A
G
C
A
G
G
G
G
G
C
T
G
G
G
T
C
T
G
G
C
G
A
G
A
C
C
A
G
G
A
G
A
C
G
G
A
C
G
G
A
C
C
G
C
0.021526
0.013699
0.021526
0
0.011742
0.027397
0.029354
0.019569
0.023483
0.056751
0.064579
0.001957
0
0
0.005871
0.021526
0.084149
0.04501
0.093933
0.054795
0.015656
0.052838
0.017613
0.043053
0.021526
0.041096
0.041096
0.084149
0.052838
0.011742
0.007828
0.013699
0
35,529
A
G
G
G
C
C
A
G
A
A
G
G
T
G
C
A
G
C
T
G
G
A
G
C
C
G
C
A
G
A
G
C
C
G
G
G
T
C
T
G
G
T
T
C
A
A
G
T
C
T
A
G
G
A
T
G
A
C
A
C
C
G
T
C
A
T
0.013699
0.02544
0.033268
0.007828
0.027397
0.04501
0.001957
0.033268
0.046967
0.043053
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0.037182
0.080235
0.068493
0.054795
0.011742
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0.04501
0.029354
0.037182
0.04501
0.033268
0.056751
0.007828
0.007828
0.033268
0
35,530
T
T
C
C
C
A
A
A
C
A
C
T
C
C
T
G
G
G
C
T
C
A
C
C
T
G
G
G
G
C
T
C
C
G
T
G
T
G
A
G
C
A
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G
G
A
G
C
C
T
G
G
A
G
A
T
G
C
A
G
A
A
A
A
T
0.021526
0.011742
0.02544
0.013699
0.037182
0.029354
0.013699
0.02544
0.035225
0.050881
0.046967
0.009785
0.027397
0.035225
0.019569
0.052838
0.078278
0.080235
0.074364
0.005871
0.005871
0.001957
0.009785
0.043053
0.027397
0.029354
0.037182
0.046967
0.056751
0.011742
0.003914
0.031311
0
35,531
C
T
T
C
C
T
T
G
G
G
A
A
T
C
C
A
G
G
C
C
A
C
T
A
G
G
A
T
G
T
A
C
C
C
C
C
A
C
T
T
C
C
T
T
G
G
G
G
G
T
G
C
A
T
G
T
A
A
G
T
T
T
C
T
C
T
0.009785
0.013699
0.043053
0.033268
0.017613
0.033268
0.001957
0.02544
0.041096
0.023483
0.078278
0.013699
0.015656
0.035225
0.011742
0.027397
0.050881
0.056751
0.093933
0.009785
0.009785
0.001957
0.031311
0.043053
0.056751
0.023483
0.029354
0.046967
0.064579
0.013699
0.019569
0.023483
0
35,532
C
T
C
T
G
G
A
C
A
T
A
T
G
A
G
G
G
C
C
T
A
C
A
A
G
C
C
A
C
C
T
G
C
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C
A
G
A
C
T
T
C
T
C
C
A
G
C
T
G
G
G
A
G
C
C
C
T
G
A
C
T
C
A
G
T
0.005871
0.017613
0.031311
0.003914
0.021526
0.029354
0.005871
0.027397
0.043053
0.041096
0.066536
0.005871
0.017613
0.031311
0.015656
0.035225
0.076321
0.066536
0.099804
0.011742
0.007828
0.013699
0.007828
0.060665
0.033268
0.027397
0.033268
0.064579
0.050881
0.005871
0.003914
0.037182
0
35,533
C
C
A
G
G
G
A
C
A
G
C
A
C
C
A
C
T
C
C
G
G
T
C
T
C
T
T
C
C
A
C
C
T
G
G
C
T
G
G
G
G
T
A
C
A
A
G
G
C
A
G
A
A
A
G
G
G
A
G
G
T
G
G
G
A
C
0.046967
0.017613
0.035225
0.02544
0.037182
0.033268
0.001957
0.015656
0.033268
0.035225
0.072407
0.015656
0.001957
0.019569
0.031311
0.033268
0.068493
0.052838
0.086106
0.011742
0.003914
0.017613
0.005871
0.046967
0.02544
0.031311
0.039139
0.056751
0.046967
0.007828
0.021526
0.021526
0
35,534
A
G
G
T
T
C
C
T
G
G
C
C
T
C
T
C
C
T
G
C
C
C
T
G
G
G
G
A
C
T
C
T
C
T
T
G
G
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C
A
G
G
G
T
T
G
G
C
A
A
C
C
G
G
G
G
A
G
T
G
T
G
C
C
A
G
0.031311
0.02544
0.035225
0.007828
0.02544
0.031311
0.009785
0.017613
0.054795
0.048924
0.07045
0.007828
0.011742
0.007828
0.027397
0.037182
0.078278
0.052838
0.066536
0.019569
0.003914
0.005871
0.005871
0.072407
0.027397
0.019569
0.043053
0.066536
0.04501
0.001957
0.011742
0.029354
0
35,535
C
A
G
C
T
G
A
C
C
A
G
A
G
G
T
C
A
C
A
G
G
G
C
A
C
A
G
A
T
A
A
C
C
A
C
A
G
G
G
A
A
G
A
G
G
C
T
G
C
A
G
A
T
A
A
T
C
A
G
A
G
G
G
C
G
T
0.005871
0.007828
0.023483
0.015656
0.019569
0.027397
0.001957
0.003914
0.062622
0.054795
0.086106
0.023483
0.035225
0.007828
0.005871
0.013699
0.125245
0.041096
0.09589
0.009785
0
0.003914
0.003914
0.052838
0.019569
0.021526
0.054795
0.078278
0.029354
0.009785
0.021526
0.037182
0
35,536
C
T
G
G
A
C
G
G
T
G
G
C
C
C
C
A
G
C
C
T
C
C
G
G
T
T
T
C
T
C
C
C
C
C
A
G
C
C
C
A
G
G
C
A
C
A
G
A
G
C
A
C
T
T
T
C
T
T
G
C
A
G
G
C
A
T
0.017613
0.013699
0.031311
0.011742
0.027397
0.041096
0.023483
0.019569
0.041096
0.031311
0.056751
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0.017613
0.021526
0.023483
0.056751
0.052838
0.056751
0.066536
0.037182
0.007828
0.017613
0.005871
0.060665
0.027397
0.029354
0.037182
0.058708
0.052838
0.011742
0.005871
0.033268
0
35,537
G
C
C
A
C
C
A
A
T
G
G
T
G
A
G
A
A
T
G
A
T
A
G
C
A
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A
A
G
T
G
A
C
T
G
G
G
C
T
C
G
T
G
C
C
A
G
C
A
A
G
T
G
G
A
T
G
A
G
G
C
A
G
G
A
G
0.007828
0.009785
0.04501
0.007828
0.015656
0.04501
0.007828
0.015656
0.04501
0.037182
0.080235
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0.021526
0.031311
0.027397
0.04501
0.056751
0.060665
0.052838
0.021526
0.013699
0.007828
0.007828
0.068493
0.033268
0.023483
0.041096
0.074364
0.04501
0.003914
0.001957
0.043053
0
35,538
T
T
A
A
A
A
A
C
T
C
G
G
C
A
T
C
C
T
G
G
G
T
A
G
G
G
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C
T
C
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A
C
A
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A
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A
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C
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C
A
G
A
C
A
C
C
A
C
C
C
C
T
T
C
C
T
G
G
G
T
0.023483
0.015656
0.023483
0.033268
0.02544
0.04501
0.005871
0.013699
0.046967
0.031311
0.052838
0
0.033268
0.031311
0.021526
0.04501
0.068493
0.064579
0.074364
0.021526
0.005871
0.013699
0.003914
0.048924
0.043053
0.021526
0.043053
0.037182
0.056751
0.007828
0.007828
0.033268
0
35,539
C
T
T
G
G
C
C
T
C
G
C
C
T
G
C
C
C
T
G
G
C
A
T
G
G
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C
C
C
C
G
G
C
G
C
C
C
G
C
G
C
T
C
C
C
C
T
T
C
T
T
C
T
T
C
C
T
G
C
T
T
C
C
T
G
A
0.011742
0.003914
0.033268
0.003914
0.009785
0.007828
0.015656
0.009785
0.021526
0.031311
0.066536
0
0.007828
0.007828
0.013699
0.017613
0.039139
0.031311
0.11546
0.09589
0.02544
0.097847
0.005871
0.050881
0.02544
0.021526
0.031311
0.136986
0.052838
0
0.001957
0.005871
0
35,540
G
A
G
G
T
C
C
C
C
G
T
C
A
T
C
C
C
C
G
G
C
C
T
T
G
C
G
C
A
G
G
A
C
C
A
C
G
G
C
G
T
C
C
A
C
C
T
C
G
C
G
G
C
C
C
G
C
C
T
C
T
T
C
C
A
T
0.027397
0.015656
0.041096
0.009785
0.021526
0.033268
0.02544
0.015656
0.029354
0.027397
0.058708
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0.017613
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0.023483
0.029354
0.039139
0.054795
0.074364
0.04501
0.033268
0.04501
0.003914
0.048924
0.037182
0.043053
0.017613
0.054795
0.07045
0.007828
0.005871
0.015656
0
35,541
C
A
A
C
C
T
G
T
T
G
C
G
T
C
T
G
G
T
T
C
T
G
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C
G
A
C
C
C
C
G
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C
G
G
C
C
C
C
T
C
C
T
T
G
G
G
T
T
C
C
T
G
G
C
T
G
C
C
C
T
0.001957
0.017613
0.027397
0.003914
0.011742
0.033268
0.027397
0.007828
0.046967
0.035225
0.076321
0
0.021526
0.009785
0.013699
0.019569
0.074364
0.046967
0.080235
0.037182
0.033268
0.046967
0.001957
0.062622
0.031311
0.037182
0.043053
0.066536
0.060665
0.005871
0.003914
0.013699
0
35,542
G
C
T
G
T
G
A
T
G
C
C
A
T
C
C
C
A
G
G
G
T
T
C
C
C
G
G
G
T
G
C
C
C
G
G
T
A
C
C
T
G
A
C
A
G
G
T
G
C
A
T
T
A
C
C
T
G
G
T
A
G
G
C
G
C
T
0.019569
0.021526
0.033268
0.02544
0.046967
0.046967
0.009785
0.02544
0.037182
0.031311
0.04501
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0.023483
0.033268
0.039139
0.052838
0.054795
0.054795
0.046967
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0.011742
0.013699
0.011742
0.039139
0.027397
0.031311
0.037182
0.035225
0.033268
0.02544
0.013699
0.041096
0
35,543
G
T
A
T
C
C
T
A
A
C
C
T
A
C
C
C
C
C
A
C
A
G
C
C
C
C
C
A
C
T
C
C
C
G
C
G
C
G
T
C
T
T
T
T
A
A
C
C
C
C
T
T
C
C
C
C
G
C
C
G
C
A
A
C
C
T
0.003914
0.021526
0.02544
0.005871
0.029354
0.043053
0.011742
0.003914
0.023483
0.031311
0.072407
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0.015656
0.027397
0.017613
0.035225
0.04501
0.050881
0.129159
0.043053
0.021526
0.041096
0.011742
0.048924
0.02544
0.023483
0.035225
0.064579
0.058708
0.007828
0.009785
0.009785
0
35,544
G
A
C
T
C
G
T
G
A
G
A
T
T
C
C
C
T
T
C
T
A
C
C
C
A
C
T
C
C
G
G
C
C
C
T
C
G
G
G
A
C
C
C
C
T
C
T
G
C
C
C
A
T
C
C
C
C
T
G
G
C
C
G
G
T
T
0.017613
0.011742
0.031311
0.015656
0.005871
0.029354
0.009785
0.031311
0.037182
0.015656
0.064579
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0.001957
0.017613
0.023483
0.039139
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0.111546
0.060665
0.037182
0.041096
0.011742
0.064579
0.035225
0.035225
0.019569
0.064579
0.068493
0.005871
0.005871
0.019569
0
35,545
G
A
G
C
C
A
C
G
A
G
G
G
C
T
C
G
G
G
C
A
C
C
T
G
C
G
G
C
A
C
C
T
C
C
T
C
C
C
A
G
C
A
T
G
G
A
G
G
A
G
C
C
T
G
C
G
C
C
C
C
A
A
A
G
C
T
0.023483
0.003914
0.027397
0.005871
0.027397
0.033268
0.015656
0.019569
0.021526
0.046967
0.084149
0.003914
0.017613
0.033268
0.005871
0.048924
0.066536
0.060665
0.07045
0.011742
0.011742
0.015656
0.015656
0.062622
0.017613
0.027397
0.043053
0.054795
0.068493
0.017613
0.013699
0.023483
0
35,546
C
G
G
G
C
T
G
C
T
G
C
T
G
C
T
G
G
G
G
T
C
C
C
A
G
A
T
G
C
G
G
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C
G
G
T
G
C
C
A
T
C
A
G
C
A
G
A
A
C
A
G
G
A
G
G
C
C
A
G
G
C
G
C
T
T
0.001957
0.005871
0.015656
0.005871
0.021526
0.041096
0.017613
0.013699
0.023483
0.060665
0.066536
0.001957
0.011742
0.007828
0.005871
0.062622
0.099804
0.078278
0.107632
0.02544
0.001957
0.017613
0.001957
0.046967
0.021526
0.02544
0.048924
0.080235
0.050881
0
0
0.029354
0
35,547
C
T
C
G
A
G
A
C
T
C
C
A
A
G
G
G
G
C
T
C
G
C
A
G
C
G
G
C
G
G
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G
C
C
C
A
C
C
G
C
C
A
A
C
G
G
G
G
G
C
C
T
G
G
C
G
C
T
G
G
C
C
T
C
C
G
0.007828
0.02544
0.035225
0.003914
0.013699
0.029354
0.015656
0.027397
0.013699
0.072407
0.043053
0
0.009785
0.007828
0.02544
0.033268
0.066536
0.066536
0.064579
0.048924
0.023483
0.064579
0.009785
0.04501
0.029354
0.023483
0.035225
0.074364
0.054795
0.003914
0.009785
0.015656
0
35,548
C
C
C
A
C
T
C
T
G
T
C
T
G
G
C
A
C
G
T
T
A
G
G
T
C
C
T
G
G
C
A
A
T
C
T
C
C
G
T
T
G
C
T
G
A
C
A
G
C
C
T
C
T
C
T
G
T
T
C
T
G
C
A
G
T
G
0.009785
0.023483
0.019569
0.011742
0.035225
0.031311
0.013699
0.02544
0.037182
0.033268
0.072407
0.003914
0.019569
0.023483
0.017613
0.041096
0.076321
0.054795
0.078278
0.021526
0.005871
0.009785
0.009785
0.060665
0.021526
0.02544
0.039139
0.062622
0.054795
0.015656
0.015656
0.029354
0
35,549
T
C
C
A
C
G
T
G
G
C
T
C
T
G
G
C
G
G
A
T
C
C
T
C
G
T
G
G
C
G
T
C
C
T
G
T
C
C
G
T
G
G
A
C
A
A
A
C
T
G
G
T
A
G
C
A
G
C
T
G
C
G
G
C
C
T
0.009785
0.013699
0.019569
0.007828
0.037182
0.04501
0.015656
0.027397
0.033268
0.043053
0.052838
0.001957
0.015656
0.013699
0.023483
0.062622
0.072407
0.078278
0.099804
0.013699
0.005871
0.015656
0.007828
0.056751
0.011742
0.039139
0.035225
0.039139
0.060665
0.009785
0.007828
0.023483
0
35,550
C
A
G
C
T
G
C
A
T
G
G
G
T
C
C
T
C
G
C
A
G
C
G
C
C
G
C
C
A
G
G
C
C
C
A
C
G
G
C
G
T
A
C
G
A
G
G
C
G
C
T
G
C
C
C
C
A
C
A
C
C
A
C
G
C
T
0.003914
0.007828
0.011742
0.003914
0.019569
0.027397
0.033268
0.003914
0.021526
0.046967
0.064579
0.003914
0.013699
0.02544
0.009785
0.037182
0.068493
0.064579
0.084149
0.048924
0.019569
0.062622
0.013699
0.043053
0.011742
0.031311
0.041096
0.107632
0.043053
0.007828
0.001957
0.015656
0
35,551
C
T
A
C
A
A
C
C
G
G
C
C
C
C
G
G
C
C
C
A
A
G
G
C
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G
C
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C
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C
C
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C
T
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C
A
C
C
G
C
C
A
C
C
C
C
A
C
C
C
C
C
C
G
G
0.015656
0.015656
0.031311
0.003914
0.02544
0.039139
0.019569
0.009785
0.021526
0.062622
0.043053
0.003914
0.011742
0.011742
0.027397
0.043053
0.062622
0.050881
0.113503
0.060665
0.017613
0.019569
0.007828
0.037182
0.017613
0.02544
0.050881
0.082192
0.035225
0.009785
0.005871
0.017613
0
35,552
C
G
G
A
G
T
C
C
C
C
T
T
C
A
G
T
C
C
G
G
A
G
G
A
G
C
C
C
C
T
G
C
T
G
G
A
G
C
C
C
C
A
G
G
C
C
C
C
T
G
G
C
A
C
G
C
C
T
T
C
C
A
G
C
C
C
0.007828
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0.054795
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0.005871
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0.033268
0.015656
0.017613
0.056751
0.058708
0.001957
0.001957
0.031311
0
35,553
G
C
G
T
T
T
C
T
G
C
A
A
G
G
T
G
G
T
G
G
C
G
G
C
C
C
C
T
C
C
G
C
T
G
C
C
G
G
G
G
G
C
C
G
C
T
C
G
C
T
G
A
C
C
G
C
G
C
C
C
G
C
C
G
G
C
0.005871
0.013699
0.019569
0.003914
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0.031311
0.02544
0.021526
0.041096
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0
0.009785
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0.04501
0.099804
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0.015656
0.035225
0.035225
0.080235
0.054795
0.003914
0.015656
0.015656
0
35,554
C
G
G
C
G
G
G
C
G
C
C
G
G
G
A
C
A
G
G
C
G
G
C
A
C
G
C
C
C
G
G
G
C
G
G
G
C
A
G
C
A
C
A
C
G
G
A
G
G
G
G
A
C
G
G
C
G
C
G
C
T
G
G
G
C
A
0
0.003914
0.007828
0
0.013699
0.029354
0.023483
0.009785
0.031311
0.064579
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0.101761
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0.027397
0.033268
0.099804
0.04501
0.017613
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0.007828
0
35,555
A
G
C
T
G
A
A
A
C
G
C
C
A
G
C
A
C
G
A
G
G
A
G
G
G
C
G
C
G
G
G
G
C
G
C
A
G
G
C
G
C
A
A
G
G
T
G
C
T
G
C
G
G
C
T
G
C
A
G
G
A
G
G
A
G
T
0.015656
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0.048924
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0.019569
0
35,556
A
G
G
C
C
G
A
C
A
A
G
C
A
C
C
C
A
C
C
A
T
G
G
C
C
A
T
G
C
T
C
C
C
T
A
T
G
T
G
T
C
G
G
G
T
C
A
C
T
G
G
A
A
C
C
A
C
G
G
G
G
A
T
C
G
T
0.060665
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0.046967
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0.015656
0.019569
0
35,557
C
T
A
G
C
C
C
G
G
A
G
A
A
G
A
T
C
G
T
C
C
T
G
G
G
G
C
A
G
C
C
G
C
C
C
T
C
T
G
C
C
A
C
C
C
C
C
A
C
G
G
C
C
A
T
C
C
T
C
A
C
T
C
A
G
T
0.005871
0.005871
0.019569
0
0.011742
0.037182
0.009785
0.011742
0.019569
0.033268
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0
0.015656
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0.062622
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0.013699
0.017613
0.050881
0.11546
0.039139
0.005871
0.003914
0.017613
0
35,558
G
G
G
C
T
C
C
C
T
G
A
T
G
C
T
T
C
T
C
T
T
C
G
T
G
G
A
A
A
C
G
A
C
G
C
G
A
A
A
T
T
C
C
T
C
A
G
C
T
T
G
C
A
T
C
T
T
C
C
C
T
G
T
T
A
T
0.041096
0.017613
0.082192
0.017613
0.013699
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0.072407
0.007828
0.029354
0.029354
0.076321
0.005871
0.019569
0.027397
0
35,559
T
G
C
C
T
A
A
G
A
A
C
T
C
T
G
A
C
A
C
T
A
G
T
A
T
A
G
A
C
A
G
G
C
C
C
G
C
A
C
T
G
A
C
T
C
T
G
A
G
A
T
A
C
A
T
C
A
C
G
T
A
C
C
A
G
T
0.04501
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0.035225
0.043053
0
35,560
T
C
C
C
A
G
G
G
C
A
G
C
T
T
C
T
T
A
G
G
C
A
G
T
C
T
G
T
G
G
T
G
C
T
C
A
G
T
C
A
C
C
T
C
T
G
T
C
T
T
C
G
A
T
G
A
G
A
A
A
C
A
G
C
A
G
0.017613
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0.023483
0.04501
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0.02544
0.039139
0
35,561
T
G
C
A
C
A
C
C
A
C
A
C
A
A
G
G
T
T
C
T
C
C
T
T
T
G
A
T
C
C
T
T
C
G
T
T
A
G
T
G
C
A
G
T
T
A
A
A
A
T
A
A
T
T
C
T
T
G
T
T
T
T
T
A
T
T
0.04501
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0.041096
0.033268
0.043053
0.035225
0.017613
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0.039139
0.023483
0.035225
0.023483
0.029354
0.009785
0.031311
0.048924
0
35,562
T
G
A
C
A
C
G
A
A
T
G
G
A
G
A
T
G
G
G
G
A
G
A
T
C
A
C
C
C
T
G
G
T
G
G
A
G
C
T
A
C
A
G
C
A
G
G
C
C
A
T
G
C
A
G
A
G
A
C
T
C
C
T
G
G
C
0.091977
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0.013699
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0.04501
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0.04501
0.019569
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0.011742
0.013699
0.052838
0.035225
0.029354
0.019569
0.02544
0.043053
0.005871
0.013699
0.048924
0
35,563
G
G
T
T
C
G
A
G
T
T
C
A
C
C
C
C
T
C
A
C
C
A
C
G
C
T
G
G
C
T
T
C
T
C
T
G
C
A
C
T
G
G
G
G
G
C
C
T
T
T
G
T
T
T
C
C
A
T
A
A
C
C
C
A
C
C
0.043053
0.02544
0.043053
0.035225
0.023483
0.041096
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0.066536
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0.007828
0.013699
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0.062622
0.027397
0.029354
0.017613
0.048924
0.015656
0.019569
0.037182
0
35,564
G
G
A
A
T
G
A
C
T
T
A
C
T
T
C
T
C
T
G
G
T
T
T
G
C
T
T
A
G
A
G
A
T
A
A
C
C
A
T
G
T
A
G
G
C
C
C
A
G
A
A
G
T
C
G
G
T
C
A
G
A
G
A
G
T
C
0.04501
0.021526
0.048924
0.029354
0.027397
0.043053
0.003914
0.037182
0.050881
0.02544
0.041096
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0.035225
0.046967
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0.001957
0.013699
0.04501
0.033268
0.037182
0.029354
0.017613
0.033268
0.019569
0.029354
0.046967
0
35,565
G
G
C
C
A
C
C
C
T
C
C
T
C
C
C
C
T
C
A
C
T
T
A
C
C
T
C
A
T
C
A
G
C
C
T
C
A
A
T
C
C
T
T
A
G
C
T
T
C
T
T
C
A
G
A
G
C
T
T
T
C
A
G
C
A
G
0.09589
0.017613
0.056751
0.023483
0.021526
0.019569
0.005871
0.019569
0.062622
0.031311
0.062622
0.023483
0.021526
0.021526
0.013699
0.023483
0.048924
0.04501
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0.007828
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0.023483
0.046967
0.072407
0.017613
0.011742
0.035225
0.060665
0.007828
0.009785
0.029354
0
35,566
A
C
A
T
C
A
A
T
T
G
A
G
A
C
T
A
A
G
A
C
A
A
T
C
A
T
C
C
C
A
C
C
T
T
A
C
A
G
A
T
G
C
C
T
T
T
G
C
A
G
C
T
G
G
C
T
T
T
T
C
A
C
T
C
G
C
0.052838
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0.037182
0.041096
0.050881
0.021526
0.007828
0.02544
0.054795
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0.029354
0.043053
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0.037182
0.04501
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0.039139
0.017613
0.029354
0.029354
0.033268
0.017613
0.035225
0.037182
0
35,567
T
A
C
A
G
G
G
A
G
C
T
A
C
C
C
T
G
T
G
T
T
T
C
T
G
A
G
A
C
C
C
T
T
T
G
T
G
A
C
A
T
C
T
C
A
C
A
T
T
T
T
T
T
C
C
A
A
G
A
A
G
A
T
G
A
C
0.060665
0.031311
0.023483
0.056751
0.046967
0.015656
0.007828
0.02544
0.054795
0.027397
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0.048924
0.02544
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0.050881
0.023483
0.017613
0.015656
0.039139
0.017613
0.033268
0.048924
0
35,568
G
G
C
G
G
C
G
G
C
G
G
C
C
A
G
G
T
C
C
T
T
C
T
G
G
C
G
C
T
G
C
G
C
C
T
C
C
G
C
C
T
G
C
T
C
C
T
G
G
A
G
C
T
C
C
A
C
C
T
G
C
A
G
G
G
A
0.029354
0.007828
0.02544
0.007828
0.011742
0.041096
0.015656
0.021526
0.027397
0.052838
0.052838
0
0.005871
0.017613
0.019569
0.048924
0.066536
0.076321
0.082192
0.041096
0.005871
0.031311
0.011742
0.052838
0.019569
0.027397
0.035225
0.084149
0.043053
0.005871
0.001957
0.029354
0
35,569
G
G
G
G
C
C
A
G
G
C
C
T
C
A
G
T
G
T
G
T
G
T
C
G
G
G
G
C
C
C
A
G
T
T
C
A
C
C
T
T
C
C
C
T
G
C
A
G
G
T
G
G
A
G
C
T
C
C
A
G
G
A
G
C
A
C
0.027397
0.005871
0.029354
0.007828
0.007828
0.039139
0.011742
0.021526
0.029354
0.056751
0.058708
0
0.003914
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0.043053
0.066536
0.074364
0.086106
0.041096
0.007828
0.029354
0.011742
0.058708
0.023483
0.02544
0.031311
0.088063
0.046967
0.005871
0.001957
0.027397
0
35,570
A
A
T
T
T
T
C
C
T
T
C
C
C
C
T
C
C
C
C
A
G
A
G
A
A
G
A
C
C
C
C
C
C
G
G
G
T
T
T
T
G
A
G
G
C
C
A
G
C
G
A
T
G
A
C
T
A
C
C
C
C
A
T
G
A
T
0.023483
0.007828
0.031311
0.007828
0.013699
0.033268
0.003914
0.021526
0.02544
0.052838
0.064579
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0.015656
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0.068493
0.068493
0.103718
0.037182
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0.033268
0.017613
0.029354
0.088063
0.048924
0.007828
0.003914
0.023483
0
35,571
C
A
T
C
A
T
C
C
C
C
G
C
C
A
C
T
G
A
G
C
A
G
G
A
A
G
G
G
C
T
C
C
C
G
G
C
G
G
C
T
C
C
A
G
C
T
G
A
T
G
A
C
A
T
T
G
A
C
G
T
C
C
C
C
A
T
0.02544
0.017613
0.033268
0.011742
0.019569
0.02544
0.005871
0.027397
0.033268
0.056751
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0.064579
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0.029354
0.001957
0.021526
0.019569
0.056751
0.029354
0.023483
0.031311
0.058708
0.054795
0.013699
0.007828
0.037182
0
35,572
G
A
A
A
G
T
C
C
C
G
G
G
C
C
T
G
A
A
C
A
G
G
G
A
C
C
C
G
A
C
A
G
T
C
C
T
G
G
G
C
A
A
C
G
G
G
A
A
A
C
A
A
G
C
C
C
C
A
A
G
C
C
T
G
A
C
0.007828
0.017613
0.029354
0.007828
0.023483
0.033268
0.009785
0.013699
0.04501
0.043053
0.056751
0
0.005871
0.013699
0.011742
0.027397
0.056751
0.046967
0.138943
0.058708
0.017613
0.019569
0
0.072407
0.043053
0.035225
0.015656
0.054795
0.072407
0
0
0.021526
0
35,573
C
C
T
G
C
C
C
T
C
T
A
T
G
G
A
C
G
A
C
A
G
C
C
C
G
G
A
G
C
T
G
C
C
C
A
C
G
G
G
C
T
G
C
A
G
C
C
A
G
T
A
T
G
C
C
A
G
G
G
A
G
C
T
G
C
T
0.033268
0.013699
0.02544
0.029354
0.023483
0.015656
0.023483
0.011742
0.035225
0.041096
0.048924
0.027397
0.019569
0.021526
0.015656
0.027397
0.052838
0.035225
0.091977
0.04501
0.011742
0.033268
0.013699
0.04501
0.031311
0.029354
0.041096
0.052838
0.058708
0.003914
0.021526
0.019569
0
35,574
G
G
G
A
G
G
G
G
G
T
C
A
G
G
G
C
C
G
G
A
A
G
G
A
G
C
T
G
A
C
A
C
C
G
G
C
T
G
T
C
T
C
T
G
A
G
G
A
G
G
G
G
C
T
G
T
T
G
G
A
G
G
G
A
G
T
0.031311
0.011742
0.033268
0.009785
0.037182
0.033268
0.003914
0.023483
0.041096
0.041096
0.074364
0.007828
0.013699
0.023483
0.027397
0.037182
0.064579
0.050881
0.064579
0.015656
0.005871
0.013699
0.013699
0.07045
0.019569
0.031311
0.037182
0.048924
0.058708
0.017613
0.007828
0.029354
0
35,575
C
T
C
A
A
T
G
C
C
A
T
C
G
C
C
A
G
C
A
A
A
C
A
C
C
A
C
A
T
C
A
C
C
G
T
G
G
G
A
G
G
T
G
T
C
A
A
T
G
T
T
C
T
C
C
C
G
A
C
A
C
C
A
G
G
T
0.021526
0.015656
0.023483
0.017613
0.039139
0.04501
0.015656
0.019569
0.021526
0.02544
0.054795
0.005871
0.021526
0.041096
0.023483
0.050881
0.043053
0.058708
0.060665
0.043053
0.021526
0.017613
0.011742
0.043053
0.021526
0.031311
0.035225
0.062622
0.046967
0.021526
0.011742
0.027397
0