row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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f_64_ref__32
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f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
C
G
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G
G
G
A
A
A
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C
C
C
A
A
A
T
C
C
C
C
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A
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A
A
A
G
G
G
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G
G
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C
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C
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C
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C
A
A
A
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C
C
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C
A
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T
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T
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G
C
C
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T
G
G
C
A
G
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G
G
A
G
C
G
G
C
C
G
A
G
C
A
A
A
C
C
C
A
G
G
T
C
C
C
A
A
A
A
G
A
A
A
A
G
G
T
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0
35,579
C
T
T
C
C
T
G
C
C
A
C
T
A
C
C
A
G
G
C
C
T
G
C
C
C
C
C
C
G
C
A
C
T
C
C
C
G
G
A
G
C
C
A
C
C
C
G
G
A
A
T
C
C
T
G
G
C
C
C
C
C
C
A
G
C
C
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0
35,580
G
T
C
G
C
A
G
C
C
C
T
C
G
C
T
G
G
G
T
G
T
C
A
G
C
C
A
G
C
C
C
A
C
G
C
G
C
G
C
G
C
T
C
C
T
G
T
T
C
G
T
C
A
T
T
C
T
C
T
G
C
C
C
A
G
G
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0
35,581
C
T
T
G
T
C
G
C
A
G
A
T
A
A
C
C
A
C
T
C
G
G
G
C
C
C
C
G
C
T
G
T
T
C
A
C
T
G
A
G
A
A
T
A
G
G
A
A
G
G
G
A
A
C
A
G
G
T
T
A
C
T
C
T
C
C
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0
35,582
C
C
C
A
C
G
C
G
G
G
C
C
C
C
C
A
G
G
G
G
G
T
G
G
G
A
C
C
T
C
C
T
C
C
A
C
G
C
C
C
A
C
T
C
C
C
T
C
G
G
C
G
A
G
A
G
A
A
C
C
C
C
G
T
G
A
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0.052838
0.084149
0.005871
0.003914
0.013699
0
35,583
G
G
G
A
G
A
T
C
T
G
G
G
G
G
G
A
G
G
G
G
T
C
T
C
C
T
G
G
C
G
C
G
T
G
G
G
G
T
C
C
G
A
A
G
G
A
G
G
C
A
G
C
G
G
C
A
C
A
C
C
G
G
G
A
A
C
0.009785
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0.019569
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0.013699
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0
0.027397
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0.052838
0.066536
0.119374
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0.009785
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0.052838
0.091977
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0.003914
0.015656
0
35,584
G
A
G
C
G
C
A
T
T
G
C
C
T
C
T
C
T
T
C
C
C
A
A
A
G
G
C
G
T
G
G
A
T
C
T
T
G
T
T
T
A
C
T
G
C
C
C
G
G
G
T
G
G
G
C
T
T
C
T
G
A
G
G
A
G
C
0.041096
0.019569
0.043053
0.015656
0.035225
0.031311
0.013699
0.021526
0.046967
0.033268
0.062622
0.011742
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0.029354
0.039139
0.048924
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0.056751
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0.029354
0.039139
0.054795
0.007828
0.019569
0.031311
0
35,585
G
A
G
G
T
C
C
C
A
G
G
C
C
C
C
T
C
A
G
G
C
G
G
C
T
C
C
A
G
G
C
G
C
G
G
C
T
G
A
G
G
A
G
G
C
C
C
A
T
C
A
C
T
G
G
G
G
A
C
A
G
G
A
G
G
T
0.043053
0.015656
0.031311
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0.017613
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0.011742
0.02544
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0.033268
0.021526
0.019569
0.068493
0.058708
0.011742
0.011742
0.029354
0
35,586
C
C
C
T
G
G
G
G
C
A
G
C
T
T
C
T
C
C
T
T
T
C
C
C
A
G
T
T
T
C
T
T
T
G
T
G
T
G
C
C
T
T
T
T
C
C
T
C
C
T
T
C
T
C
C
T
C
G
G
A
C
G
C
C
T
C
0.023483
0.009785
0.07045
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0.009785
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0.039139
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0.062622
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0.066536
0.054795
0.02544
0.021526
0.04501
0.076321
0.009785
0.005871
0.031311
0
35,587
C
T
T
C
T
C
A
G
C
T
G
C
C
C
C
C
A
A
A
G
C
C
T
T
G
A
C
C
T
C
A
C
C
C
T
C
C
T
C
T
T
C
A
T
C
A
C
T
G
G
G
T
T
G
G
C
A
C
C
A
C
C
A
G
G
T
0.019569
0.007828
0.064579
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0.023483
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0.021526
0.058708
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0.017613
0.043053
0.080235
0.007828
0.003914
0.039139
0
35,588
A
G
C
T
T
C
T
C
C
A
T
C
C
T
T
C
T
C
A
G
C
T
G
C
C
C
C
C
A
A
A
G
C
C
T
T
G
A
C
C
T
C
A
C
C
C
T
C
C
T
C
T
T
C
A
T
C
A
C
T
G
G
G
T
T
G
0.019569
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0.033268
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0.029354
0.017613
0.043053
0.084149
0.007828
0.003914
0.037182
0
35,589
G
C
C
T
C
A
G
C
C
T
C
C
A
G
A
G
T
A
T
C
T
G
G
G
A
T
T
A
C
A
G
G
C
G
C
A
T
G
A
C
A
C
C
A
C
A
C
C
C
A
G
C
T
A
A
T
T
T
T
T
T
T
T
G
T
T
0.064579
0.017613
0.02544
0.021526
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0.027397
0.009785
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0.052838
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0.02544
0.031311
0.054795
0.027397
0.017613
0.015656
0.041096
0
35,590
G
A
G
G
C
A
G
G
G
G
C
T
C
A
G
C
T
C
C
T
C
C
T
G
G
G
C
C
T
G
G
G
T
G
A
T
G
C
G
G
C
G
T
G
C
G
A
A
G
C
G
G
C
T
G
C
G
A
T
C
C
C
G
A
G
C
0.021526
0.009785
0.027397
0.011742
0.02544
0.02544
0.013699
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0.052838
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0.023483
0.02544
0.050881
0.080235
0.046967
0.001957
0.007828
0.017613
0
35,591
G
A
T
T
G
C
C
A
A
G
G
A
G
G
C
T
T
C
G
T
G
C
C
T
C
A
T
A
T
G
G
T
C
G
C
T
G
T
C
C
G
T
G
C
C
A
C
C
C
T
C
G
C
C
T
T
T
C
A
G
G
G
C
C
T
T
0.027397
0.011742
0.043053
0.017613
0.02544
0.031311
0.017613
0.023483
0.029354
0.046967
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0.037182
0.035225
0.052838
0.052838
0.060665
0.019569
0.013699
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0.046967
0.023483
0.033268
0.043053
0.058708
0.048924
0.019569
0.011742
0.02544
0
35,592
T
G
G
G
A
G
C
C
A
G
G
A
T
A
A
G
A
A
A
G
G
G
G
A
C
T
G
G
A
G
A
C
C
G
A
G
A
T
T
C
C
T
G
A
A
C
A
C
T
G
A
G
G
A
A
G
G
A
A
G
G
A
G
G
G
T
0.029354
0.023483
0.031311
0.033268
0.017613
0.043053
0.009785
0.027397
0.041096
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0.037182
0.031311
0.019569
0.080235
0.007828
0.015656
0.02544
0
35,593
C
T
G
C
T
G
T
T
C
C
A
G
C
T
T
C
T
G
C
A
G
C
C
T
C
A
T
A
G
C
A
G
C
G
A
G
C
T
C
A
T
G
C
C
C
C
A
G
G
A
T
G
C
T
G
A
G
A
G
A
G
A
C
A
C
T
0.015656
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0.052838
0.054795
0.003914
0.003914
0.039139
0
35,594
A
G
C
A
C
C
C
C
C
A
T
C
G
C
C
C
T
C
G
C
C
A
C
T
C
A
C
C
C
A
C
G
C
T
C
G
G
G
T
C
C
T
T
G
G
C
C
A
G
C
T
C
C
T
C
A
T
A
G
G
A
G
C
C
G
T
0.031311
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0.02544
0.07045
0.054795
0.009785
0.011742
0.013699
0
35,595
G
T
C
T
T
T
G
G
A
G
G
G
C
A
G
A
A
G
C
C
A
G
A
G
A
A
G
A
T
T
T
C
T
G
T
C
G
T
G
G
G
A
A
G
G
C
G
T
C
A
T
G
A
A
A
C
A
G
G
T
A
C
C
A
T
C
0.023483
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0.027397
0.027397
0.027397
0.009785
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0.074364
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0.046967
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0.02544
0.043053
0.052838
0.009785
0.017613
0.035225
0
35,596
C
A
C
G
G
C
C
T
C
C
G
T
G
A
G
C
G
G
C
A
C
C
A
A
G
G
G
C
A
T
G
G
T
A
C
A
G
G
T
G
A
G
G
C
A
T
G
G
C
G
G
G
C
C
C
A
A
G
C
G
C
T
G
G
G
C
0.019569
0.013699
0.041096
0.021526
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0.035225
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0.043053
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0.023483
0.054795
0.058708
0.041096
0.011742
0.017613
0.033268
0
35,597
G
A
C
G
T
G
C
T
T
G
G
C
C
T
C
A
T
A
A
C
T
C
A
T
G
C
C
T
G
C
C
C
C
G
T
T
G
T
C
A
A
A
A
T
T
G
C
A
G
T
C
C
T
T
T
G
G
G
A
C
T
G
G
G
G
T
0.019569
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0.017613
0.066536
0.050881
0.052838
0.007828
0.009785
0.02544
0
35,598
G
C
T
T
C
G
G
C
C
A
T
G
G
T
G
C
C
A
C
C
C
C
A
T
C
A
A
T
G
C
C
A
T
C
C
T
G
G
C
T
G
T
C
G
A
G
A
A
G
G
A
G
G
G
C
T
G
C
C
C
A
G
T
G
T
C
0.003914
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0.054795
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0.009785
0.031311
0.046967
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0.013699
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0.023483
0.031311
0.052838
0.07045
0.04501
0.005871
0
0.023483
0
35,599
G
G
G
C
A
T
G
G
G
C
A
T
C
C
A
G
G
G
A
G
C
C
G
C
T
T
C
G
G
C
C
A
T
G
G
T
G
C
C
A
C
C
C
C
A
T
C
A
A
T
G
C
C
A
T
C
C
T
G
G
C
T
G
T
C
C
0.003914
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0.054795
0.072407
0.043053
0.005871
0
0.023483
0
35,600
C
C
T
T
C
T
C
C
A
C
A
G
C
C
A
G
G
G
T
G
G
C
A
T
T
G
A
T
G
G
G
G
C
G
G
C
A
C
C
G
T
G
G
C
C
G
A
A
G
C
G
G
C
T
C
C
T
T
G
G
A
T
G
C
C
T
0.003914
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0.021526
0.005871
0.031311
0.056751
0.009785
0.007828
0.039139
0.043053
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0.011742
0.060665
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0.021526
0.033268
0.050881
0.066536
0.041096
0.007828
0
0.027397
0
35,601
C
C
C
C
T
T
G
A
C
C
T
G
T
G
A
T
G
A
C
C
C
C
C
G
C
T
T
C
C
A
G
G
C
C
T
C
C
T
C
T
T
C
C
T
C
A
A
A
G
G
C
C
C
C
T
C
C
C
C
C
C
A
G
C
C
A
0.015656
0.011742
0.02544
0.011742
0.037182
0.04501
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0.031311
0.035225
0.056751
0.04501
0.013699
0.005871
0.031311
0
35,602
C
G
A
A
G
A
G
G
C
T
G
G
G
A
T
G
T
T
C
A
G
C
C
A
T
G
T
G
G
A
C
A
T
G
C
A
G
C
C
T
T
G
T
G
G
C
C
C
A
C
T
G
G
A
G
G
G
C
A
A
G
G
C
C
A
C
0.015656
0.019569
0.021526
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0.058708
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0.023483
0.035225
0.031311
0.046967
0.050881
0.013699
0.009785
0.033268
0
35,603
T
C
T
G
A
G
T
G
C
T
G
G
G
G
C
A
G
A
A
C
T
G
A
G
G
A
C
A
A
C
G
C
T
G
C
C
T
A
C
C
C
T
T
A
A
G
A
G
C
G
T
C
T
G
A
G
G
G
C
G
A
A
G
G
C
C
0.005871
0.019569
0.027397
0.005871
0.02544
0.035225
0.013699
0.031311
0.046967
0.02544
0.068493
0
0.003914
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0.039139
0.064579
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0.043053
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0.029354
0.043053
0.037182
0.064579
0.050881
0.003914
0.009785
0.029354
0
35,604
T
T
C
C
C
C
A
G
G
G
A
A
T
G
G
G
G
G
T
G
G
T
A
T
G
G
A
G
C
C
C
G
C
A
G
G
G
G
C
A
G
A
C
C
G
C
T
C
C
C
A
A
T
C
C
T
A
T
C
C
C
T
G
T
G
A
0.035225
0.013699
0.021526
0.019569
0.019569
0.017613
0.011742
0.019569
0.031311
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0.02544
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0.023483
0.029354
0.035225
0.074364
0.048924
0.003914
0.011742
0.035225
0
35,605
A
C
C
C
A
G
A
C
C
G
T
G
A
A
A
A
G
G
A
G
G
A
T
G
A
A
G
A
T
G
T
C
T
C
C
A
A
G
G
A
A
T
A
T
G
G
G
C
A
C
C
T
A
C
T
C
C
C
A
G
G
C
C
A
C
G
0.013699
0.011742
0.02544
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0.035225
0.035225
0.009785
0.015656
0.048924
0.04501
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0.052838
0.062622
0.07045
0.048924
0.023483
0.009785
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0.009785
0.068493
0.029354
0.029354
0.031311
0.056751
0.056751
0.001957
0
0.041096
0
35,606
C
G
A
G
G
G
G
A
A
G
G
T
T
T
G
T
G
G
G
G
G
C
A
T
C
T
G
A
C
C
A
G
C
C
A
C
A
A
G
T
C
C
C
G
A
C
A
G
A
T
A
G
G
A
A
G
T
G
C
T
T
G
A
G
A
T
0.035225
0.02544
0.043053
0.031311
0.041096
0.029354
0.009785
0.017613
0.035225
0.029354
0.058708
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0.013699
0.041096
0.043053
0.027397
0.033268
0.033268
0.076321
0.015656
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0.005871
0.017613
0.048924
0.029354
0.031311
0.027397
0.039139
0.039139
0.013699
0.027397
0.043053
0
35,607
T
T
G
G
G
C
G
T
C
A
G
C
A
T
C
A
T
G
G
A
T
A
G
G
A
G
C
T
G
C
A
G
C
G
G
A
G
G
G
G
A
T
C
A
C
C
A
G
G
G
T
A
G
A
G
A
G
G
A
G
C
A
G
C
A
T
0.009785
0.009785
0.043053
0.001957
0.019569
0.031311
0.007828
0.023483
0.050881
0.039139
0.068493
0.007828
0.019569
0.017613
0.021526
0.033268
0.066536
0.056751
0.099804
0.017613
0.007828
0.02544
0.011742
0.060665
0.031311
0.027397
0.037182
0.058708
0.054795
0.011742
0.001957
0.02544
0
35,608
T
T
G
C
T
C
T
C
A
C
T
C
T
C
T
C
A
T
C
G
G
A
T
C
C
T
C
A
C
A
G
A
T
G
A
C
C
G
A
C
A
A
C
A
A
G
A
C
A
G
G
A
G
A
G
G
T
G
C
T
G
A
T
C
T
G
0.035225
0.023483
0.039139
0.013699
0.02544
0.029354
0.009785
0.023483
0.04501
0.031311
0.066536
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0.046967
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0.072407
0.039139
0.021526
0.039139
0.037182
0.07045
0.003914
0.005871
0.029354
0
35,609
C
A
G
G
C
G
G
T
G
T
C
G
C
T
T
C
T
C
G
C
T
G
A
G
C
C
A
G
T
G
G
C
C
G
C
C
C
T
C
C
A
G
G
G
C
A
T
C
C
T
G
G
T
G
G
G
A
C
C
T
C
C
G
C
C
T
0.013699
0.009785
0.037182
0.005871
0.029354
0.041096
0.007828
0.021526
0.035225
0.035225
0.064579
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0.029354
0.033268
0.027397
0.046967
0.072407
0.021526
0.009785
0.019569
0
35,610
C
C
T
G
G
A
G
T
G
G
G
A
G
G
A
G
C
T
C
T
C
G
G
T
C
C
C
C
T
C
T
T
C
T
A
G
G
A
C
G
T
C
C
T
T
G
T
G
G
G
T
C
C
C
C
T
T
G
C
G
G
A
G
T
C
T
0.013699
0.013699
0.037182
0.005871
0.027397
0.039139
0.007828
0.019569
0.037182
0.033268
0.066536
0.011742
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0.07045
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0.048924
0.027397
0.027397
0.023483
0.058708
0.07045
0.021526
0.013699
0.013699
0
35,611
T
A
T
A
T
A
T
A
G
C
A
A
T
C
T
C
A
C
C
A
G
A
T
G
G
C
A
G
T
T
G
C
C
G
G
G
A
G
G
T
C
A
G
G
G
C
T
C
C
C
T
G
G
A
A
G
G
C
G
G
T
C
T
C
C
T
0.021526
0.015656
0.035225
0.009785
0.019569
0.048924
0.009785
0.021526
0.039139
0.039139
0.084149
0.017613
0.017613
0.009785
0.021526
0.04501
0.060665
0.054795
0.072407
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0.056751
0.029354
0.023483
0.031311
0.048924
0.052838
0.015656
0.009785
0.031311
0
35,612
C
C
C
C
C
A
G
A
A
C
T
C
T
G
G
C
C
C
T
A
A
G
G
A
G
T
C
C
A
A
C
G
T
C
C
C
T
C
C
T
C
C
C
T
C
A
G
C
C
C
G
G
A
T
T
G
C
A
G
G
T
C
C
C
C
C
0.015656
0.019569
0.013699
0.021526
0.017613
0.037182
0.007828
0.033268
0.029354
0.027397
0.074364
0
0.017613
0.015656
0.02544
0.033268
0.068493
0.060665
0.09589
0.021526
0.013699
0.011742
0.013699
0.068493
0.02544
0.033268
0.031311
0.050881
0.068493
0.009785
0.003914
0.033268
0
35,613
T
C
A
G
C
A
A
T
T
A
A
T
G
G
T
G
G
C
C
A
T
G
C
C
G
C
T
T
C
T
G
C
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G
G
T
G
C
C
T
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C
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G
A
T
C
A
G
G
G
T
G
T
C
T
C
C
T
T
G
T
G
C
T
0.021526
0.009785
0.04501
0.017613
0.027397
0.017613
0.001957
0.015656
0.054795
0.046967
0.064579
0.017613
0.033268
0.02544
0.027397
0.023483
0.066536
0.054795
0.086106
0.013699
0
0.007828
0.009785
0.058708
0.031311
0.027397
0.031311
0.050881
0.064579
0.001957
0.013699
0.031311
0
35,614
T
C
C
A
G
C
C
A
C
A
G
G
T
T
C
A
G
G
T
G
A
G
G
C
T
T
T
T
C
A
G
G
C
C
T
G
A
G
G
A
G
G
A
A
C
A
A
G
G
T
C
C
A
G
G
G
C
T
G
A
G
C
A
C
A
G
0.019569
0.023483
0.031311
0.007828
0.029354
0.035225
0.007828
0.027397
0.037182
0.033268
0.086106
0.001957
0.013699
0.007828
0.033268
0.033268
0.076321
0.054795
0.066536
0.013699
0.007828
0.019569
0.003914
0.072407
0.027397
0.039139
0.023483
0.052838
0.064579
0.003914
0.001957
0.043053
0
35,615
A
A
T
C
A
G
C
A
C
C
G
A
T
C
G
C
C
T
C
C
G
C
C
T
C
G
C
T
T
A
G
C
C
C
C
A
T
T
C
C
C
A
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C
A
G
C
T
T
C
G
G
G
T
T
C
G
C
C
A
T
G
G
C
C
T
0.027397
0.021526
0.027397
0.031311
0.013699
0.035225
0.017613
0.029354
0.027397
0.029354
0.046967
0.009785
0.035225
0.021526
0.02544
0.035225
0.041096
0.046967
0.066536
0.037182
0.031311
0.027397
0.027397
0.037182
0.037182
0.02544
0.037182
0.04501
0.050881
0.013699
0.015656
0.02544
0
35,616
A
G
C
A
C
C
G
A
T
C
G
C
C
T
C
C
G
C
C
T
C
G
C
T
T
A
G
C
C
C
C
A
T
T
C
C
C
A
G
C
A
G
C
T
T
C
G
G
G
T
T
C
G
C
C
A
T
G
G
C
C
C
T
G
G
G
0.027397
0.021526
0.02544
0.031311
0.013699
0.035225
0.017613
0.027397
0.027397
0.029354
0.046967
0.009785
0.035225
0.021526
0.02544
0.033268
0.041096
0.04501
0.066536
0.039139
0.033268
0.027397
0.027397
0.037182
0.039139
0.02544
0.037182
0.046967
0.050881
0.013699
0.015656
0.02544
0
35,617
A
G
G
C
C
G
T
G
G
G
C
G
T
T
G
A
T
C
C
A
G
A
C
A
G
T
G
C
C
C
A
C
C
T
G
G
A
G
C
C
T
G
T
G
G
G
G
A
A
G
A
T
G
A
A
G
G
T
G
T
C
C
A
A
C
T
0.005871
0.013699
0.023483
0.001957
0.031311
0.02544
0.023483
0.019569
0.037182
0.027397
0.058708
0.005871
0.017613
0.021526
0.017613
0.048924
0.056751
0.050881
0.103718
0.043053
0.009785
0.04501
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0.060665
0.017613
0.029354
0.033268
0.078278
0.048924
0.007828
0.003914
0.029354
0
35,618
A
C
T
G
G
G
T
A
A
T
C
T
T
G
A
A
G
C
A
G
G
T
A
G
T
C
A
G
A
C
T
G
C
G
G
G
A
G
A
A
A
A
C
A
G
G
A
T
C
A
G
G
C
C
T
G
G
C
T
G
A
A
A
A
C
T
0.021526
0.021526
0.031311
0.007828
0.02544
0.039139
0.009785
0.021526
0.046967
0.037182
0.074364
0.001957
0.023483
0.009785
0.023483
0.035225
0.072407
0.064579
0.088063
0.011742
0.007828
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0.07045
0.023483
0.031311
0.023483
0.046967
0.064579
0.007828
0.013699
0.029354
0
35,619
G
G
A
G
G
C
A
A
C
G
C
C
A
G
A
A
T
C
C
A
G
C
A
C
C
G
G
C
C
C
C
A
T
T
T
A
C
C
C
A
A
C
T
C
T
G
T
A
C
A
A
A
G
C
C
C
T
T
G
T
C
C
C
C
A
C
0.041096
0.019569
0.023483
0.039139
0.035225
0.02544
0.007828
0.015656
0.048924
0.033268
0.048924
0.019569
0.02544
0.037182
0.035225
0.021526
0.056751
0.054795
0.066536
0.019569
0
0.011742
0.017613
0.048924
0.031311
0.023483
0.02544
0.052838
0.04501
0.019569
0.013699
0.035225
0
35,620
C
G
G
C
G
T
G
G
G
T
G
C
A
G
A
C
G
G
A
G
A
G
G
C
A
G
C
A
G
T
T
C
C
G
G
G
A
C
T
T
C
C
G
G
G
A
T
C
T
G
A
A
C
A
A
G
G
A
T
G
G
G
C
A
C
T
0.023483
0.015656
0.027397
0.009785
0.017613
0.035225
0.011742
0.02544
0.035225
0.046967
0.064579
0.007828
0.023483
0.009785
0.019569
0.033268
0.072407
0.052838
0.080235
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0.009785
0.062622
0.019569
0.031311
0.039139
0.054795
0.058708
0.009785
0.011742
0.027397
0
35,621
C
T
G
T
C
C
C
T
C
A
T
G
T
C
T
T
T
G
G
G
T
C
C
A
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A
A
G
T
C
T
T
C
C
T
G
G
G
T
C
C
C
C
C
A
G
A
G
G
C
C
C
A
G
A
G
C
T
T
C
C
T
G
A
G
T
0.019569
0.021526
0.035225
0.011742
0.023483
0.039139
0.005871
0.029354
0.050881
0.027397
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0.066536
0.07045
0.082192
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0.015656
0.066536
0.048924
0.039139
0.011742
0.037182
0.084149
0.009785
0
0.023483
0
35,622
C
A
G
G
C
C
G
G
C
C
A
G
G
A
C
A
A
T
G
A
G
C
A
G
G
A
T
G
C
C
A
C
C
T
G
T
C
A
G
C
C
C
C
A
C
A
G
C
C
A
G
G
C
T
G
G
C
C
A
C
A
T
C
C
A
A
0.02544
0.009785
0.033268
0.021526
0.033268
0.037182
0.003914
0.023483
0.029354
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0.017613
0.043053
0.072407
0.060665
0.080235
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0.009785
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0.013699
0.046967
0.033268
0.035225
0.033268
0.048924
0.058708
0.009785
0.011742
0.031311
0
35,623
T
A
C
C
C
C
A
G
A
G
G
C
T
G
C
C
A
G
C
G
C
C
T
G
C
T
C
A
T
A
G
G
T
G
G
G
G
A
G
G
C
C
T
G
G
G
G
G
T
G
G
G
G
G
T
G
G
G
G
G
T
G
G
A
G
A
0.009785
0.011742
0.027397
0.007828
0.023483
0.043053
0.019569
0.017613
0.031311
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0.078278
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0.013699
0.017613
0.041096
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0.056751
0.127202
0.023483
0.003914
0.027397
0.029354
0.050881
0.019569
0.02544
0.02544
0.068493
0.046967
0.023483
0.009785
0.019569
0
35,624
T
T
G
G
A
G
G
C
A
C
A
C
C
A
T
G
A
G
G
A
G
C
G
A
G
G
G
C
T
C
A
G
C
T
C
T
C
C
C
C
A
G
G
G
C
C
C
T
G
G
A
A
A
T
C
C
A
T
G
C
C
C
T
C
C
G
0.013699
0.02544
0.019569
0.015656
0.033268
0.058708
0.005871
0.027397
0.019569
0.029354
0.074364
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0.033268
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0.068493
0.078278
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0.003914
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0.011742
0.050881
0.021526
0.02544
0.046967
0.039139
0.050881
0.017613
0.005871
0.033268
0
35,625
A
C
T
A
A
C
C
G
G
C
T
T
T
C
C
C
G
G
T
T
T
T
A
T
T
C
C
C
G
T
A
A
C
C
C
T
G
C
A
G
C
T
C
C
A
A
C
C
C
T
G
C
T
T
G
C
G
C
C
C
C
A
C
C
A
G
0.02544
0.029354
0.019569
0.015656
0.013699
0.04501
0.021526
0.015656
0.023483
0.039139
0.052838
0.013699
0.027397
0.013699
0.017613
0.037182
0.046967
0.04501
0.082192
0.050881
0.013699
0.046967
0.031311
0.035225
0.031311
0.011742
0.039139
0.054795
0.048924
0.017613
0.015656
0.017613
0
35,626
G
C
T
C
A
T
C
C
G
C
C
C
G
A
C
C
T
C
G
C
A
G
C
T
C
C
T
G
C
A
A
G
T
C
C
C
G
C
G
C
C
G
T
C
T
G
T
G
C
C
T
G
T
T
C
G
C
G
C
T
G
T
G
C
C
C
0.003914
0.011742
0.019569
0.023483
0.023483
0.04501
0.005871
0.011742
0.023483
0.031311
0.078278
0.013699
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0.019569
0.039139
0.052838
0.043053
0.093933
0.039139
0.019569
0.029354
0.02544
0.046967
0.027397
0.02544
0.043053
0.064579
0.050881
0.007828
0.007828
0.027397
0
35,627
G
C
A
G
C
C
C
T
G
G
G
A
C
G
T
G
G
C
G
G
C
G
G
G
G
C
C
C
A
G
G
C
T
G
T
T
C
C
A
G
G
A
G
A
G
G
C
C
A
G
C
C
T
C
C
G
G
C
T
T
C
T
G
C
T
C
0.011742
0.011742
0.019569
0.009785
0.009785
0.027397
0.021526
0.009785
0.02544
0.064579
0.068493
0
0.013699
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0.023483
0.062622
0.043053
0.074364
0.064579
0.031311
0.041096
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0.076321
0.029354
0.021526
0.037182
0.076321
0.072407
0.011742
0.001957
0.011742
0
35,628
T
G
G
T
G
T
C
G
C
C
T
T
C
G
T
T
C
T
T
C
T
G
C
C
A
C
C
C
C
A
T
T
C
G
G
T
A
G
G
G
G
C
T
C
C
C
G
T
T
C
C
C
G
C
C
A
C
G
C
C
C
C
C
T
G
T
0.009785
0.013699
0.027397
0.009785
0.011742
0.037182
0.027397
0.015656
0.017613
0.035225
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0.052838
0.027397
0.031311
0.017613
0.078278
0.054795
0.015656
0.001957
0.017613
0
35,629
A
C
C
A
C
T
C
C
A
T
G
C
C
A
G
A
A
A
C
T
T
G
T
T
G
T
T
G
A
C
G
A
T
C
T
G
G
A
C
T
G
G
G
C
C
T
G
A
G
T
T
G
A
C
A
C
C
A
C
C
A
G
G
T
C
C
0.009785
0.021526
0.015656
0.003914
0.031311
0.031311
0.013699
0.027397
0.031311
0.033268
0.07045
0
0.017613
0.021526
0.023483
0.041096
0.082192
0.084149
0.105675
0.013699
0.007828
0
0.007828
0.056751
0.015656
0.039139
0.027397
0.072407
0.062622
0.001957
0.001957
0.027397
0
35,630
T
T
G
A
C
G
A
A
G
G
T
C
G
T
C
G
C
C
T
G
T
T
T
C
T
G
G
A
T
T
T
C
C
C
G
A
T
G
G
C
C
T
G
A
G
C
A
T
C
A
T
C
C
G
C
G
C
A
G
T
G
A
A
C
A
T
0.046967
0.017613
0.035225
0.029354
0.031311
0.021526
0.007828
0.02544
0.035225
0.041096
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0.011742
0.043053
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0.02544
0.046967
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0.031311
0.023483
0.035225
0.037182
0.056751
0.019569
0.013699
0.023483
0
35,631
G
T
C
T
T
C
C
A
C
T
T
T
C
G
C
C
T
T
G
G
T
G
C
C
T
G
T
C
T
T
C
G
C
C
C
A
C
C
T
G
A
G
C
A
T
C
C
T
C
C
A
G
A
G
C
C
T
C
G
T
G
C
C
A
G
T
0.023483
0.009785
0.031311
0.015656
0.023483
0.031311
0.015656
0.019569
0.029354
0.054795
0.062622
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0.021526
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0.056751
0.072407
0.09589
0.013699
0.011742
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0.021526
0.056751
0.02544
0.02544
0.027397
0.064579
0.054795
0.007828
0.009785
0.021526
0
35,632
T
C
C
A
G
A
G
A
A
C
C
T
G
A
G
A
G
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G
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C
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A
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A
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G
A
G
A
C
A
G
A
G
G
A
G
G
0.019569
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0
35,633
C
A
G
T
G
A
G
C
T
G
G
A
A
T
C
G
G
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C
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C
T
G
G
T
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T
T
A
G
T
G
G
C
C
A
C
A
G
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0.009785
0.027397
0
35,634
C
C
G
G
C
A
C
C
T
G
C
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C
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C
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C
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C
A
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C
C
T
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G
G
G
A
G
A
T
G
G
0.009785
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0.064579
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0.005871
0.019569
0
35,635
C
G
G
C
A
G
G
T
G
T
A
G
C
G
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C
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C
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G
G
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T
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T
G
G
G
C
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0.027397
0
35,636
C
T
C
G
G
C
A
G
G
T
G
T
A
G
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G
G
T
T
C
T
G
T
0.009785
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0.052838
0.009785
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0.027397
0
35,637
A
C
C
C
T
G
G
G
G
C
T
G
G
A
G
C
T
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C
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C
G
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T
A
C
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C
C
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G
C
C
G
A
G
C
G
G
A
T
0.009785
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0.033268
0.039139
0.052838
0.052838
0.009785
0.003914
0.027397
0
35,638
A
C
A
G
C
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C
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G
G
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C
C
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C
C
C
A
G
C
C
C
T
0.015656
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0.017613
0.007828
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0.017613
0.011742
0.031311
0.054795
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0
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0.009785
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0.064579
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0.043053
0.037182
0.050881
0.072407
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0
0.023483
0
35,639
G
C
A
G
C
C
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C
C
C
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C
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C
C
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T
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A
G
0.015656
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0
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0.066536
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0.072407
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0
0.023483
0
35,640
C
A
G
C
A
T
G
C
A
G
T
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C
C
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C
C
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T
G
G
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A
A
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A
G
G
A
G
T
A
A
C
0.017613
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0.048924
0.011742
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0.048924
0
35,641
A
G
C
T
G
A
G
C
A
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C
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A
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A
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C
T
C
T
G
A
C
A
G
C
T
0.015656
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0
0.019569
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0.04501
0.066536
0.041096
0.011742
0.011742
0.039139
0
35,642
G
G
T
G
T
T
A
C
C
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C
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G
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C
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C
C
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A
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C
A
T
G
T
G
C
T
G
T
T
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0
0.017613
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0.041096
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0
35,643
A
C
A
A
G
A
G
T
G
G
G
C
G
A
C
A
G
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G
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C
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G
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C
A
T
T
C
T
C
T
A
T
C
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0.04501
0.017613
0.009785
0.031311
0
35,644
C
T
C
C
T
G
C
A
G
G
C
T
C
C
G
G
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A
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T
C
A
G
A
A
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A
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A
A
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C
A
0.033268
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0.033268
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0.041096
0.039139
0.033268
0.035225
0.04501
0.015656
0.009785
0.041096
0
35,645
A
A
A
G
A
G
A
G
G
G
C
T
G
A
A
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C
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G
A
A
A
T
G
G
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C
A
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C
A
C
C
G
T
C
A
T
0.046967
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0.052838
0.015656
0.023483
0.023483
0.001957
0.041096
0.074364
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0
0.015656
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0.035225
0.027397
0.033268
0.033268
0.039139
0.011742
0.029354
0.043053
0
35,646
G
C
T
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C
C
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A
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G
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T
C
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G
T
C
T
T
G
C
0.019569
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0.041096
0.031311
0.029354
0.066536
0.009785
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0.029354
0
35,647
C
T
T
C
T
T
C
G
A
A
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A
A
A
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C
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C
A
T
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A
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A
G
C
A
A
G
T
C
0.02544
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0.048924
0.02544
0.031311
0.033268
0.009785
0.031311
0.072407
0.013699
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0.054795
0.033268
0.017613
0.013699
0.062622
0.007828
0.015656
0.037182
0
35,648
G
A
G
A
G
G
A
C
T
C
A
G
T
C
C
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A
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G
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C
A
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T
T
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C
T
G
T
0.037182
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0.043053
0.031311
0.02544
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0.009785
0.037182
0.062622
0.021526
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0.060665
0.029354
0.017613
0.009785
0.066536
0.011742
0.019569
0.035225
0
35,649
G
T
G
A
A
T
G
T
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A
A
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C
T
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A
C
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G
G
A
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C
A
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A
C
T
A
G
G
T
0.050881
0.02544
0.035225
0.027397
0.048924
0.035225
0.011742
0.046967
0.041096
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0
0.021526
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0.050881
0.033268
0.019569
0.009785
0.048924
0.023483
0.019569
0.046967
0
35,650
G
A
G
T
T
T
T
C
G
G
A
T
A
C
A
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A
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C
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A
T
G
G
A
C
A
T
0.052838
0.027397
0.037182
0.023483
0.052838
0.035225
0.007828
0.046967
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0.048924
0.02544
0.019569
0.011742
0.041096
0.031311
0.021526
0.046967
0
35,651
A
G
G
A
C
T
T
A
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C
0.056751
0.035225
0.035225
0.015656
0.056751
0.033268
0.007828
0.054795
0.035225
0.021526
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0.017613
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35,652
G
C
A
C
C
C
T
T
T
T
A
A
A
T
G
T
A
A
C
G
A
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G
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T
G
C
A
C
A
C
C
T
C
T
C
A
A
A
A
C
A
T
C
T
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0
35,653
G
C
G
G
A
A
A
G
A
C
C
T
T
C
A
G
C
C
A
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T
A
A
T
T
C
A
C
G
C
T
G
G
A
G
A
G
A
A
T
G
0.043053
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0.060665
0
35,654
T
G
C
C
C
G
A
G
G
C
G
G
C
C
C
A
G
C
C
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T
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G
C
G
C
G
G
G
T
G
G
C
G
G
G
C
C
T
G
G
C
A
0.011742
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0.017613
0
35,655
C
C
C
T
C
T
T
C
A
T
C
G
A
G
T
C
C
A
A
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G
A
G
G
G
G
A
T
G
G
A
G
A
G
A
A
C
C
A
G
C
0.04501
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0
0.011742
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0.046967
0.02544
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0
35,656
C
C
C
C
G
A
A
G
G
C
G
C
G
G
A
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C
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G
C
C
C
C
C
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G
G
C
A
C
A
G
G
C
T
G
C
T
0.013699
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0.001957
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0
35,657
C
C
C
A
G
C
C
T
G
G
A
G
G
C
C
C
C
G
G
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G
A
G
A
A
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T
T
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C
T
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G
C
C
A
G
G
T
C
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0.037182
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0.009785
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0
35,658
T
T
G
C
A
G
G
A
A
G
A
T
G
G
A
A
G
C
C
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C
T
T
G
A
T
G
G
T
G
T
A
G
C
G
G
C
C
C
T
T
0.005871
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0.054795
0.04501
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0
0.037182
0
35,659
G
G
T
A
A
T
T
G
G
T
T
A
T
C
A
G
G
A
A
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T
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T
G
T
T
C
T
T
C
A
T
C
C
A
G
A
C
C
A
C
C
T
0.009785
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0.041096
0.007828
0.015656
0.043053
0
35,660
C
G
T
G
C
A
T
C
C
G
G
A
A
G
T
T
C
C
C
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G
C
C
T
C
T
G
C
A
T
G
G
A
G
A
C
C
T
T
G
G
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0.031311
0.048924
0.046967
0.041096
0.009785
0.011742
0.041096
0
35,661
G
T
T
C
C
T
T
G
A
A
A
A
C
T
G
C
C
A
G
C
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G
G
G
T
C
C
C
C
C
C
T
C
G
G
A
G
G
A
C
G
C
0.011742
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0
35,662
C
T
C
T
G
T
A
T
C
T
C
C
C
C
A
G
G
T
G
C
G
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G
C
A
C
C
C
C
C
A
G
C
C
A
T
G
A
A
A
T
T
G
0.015656
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0
35,663
G
A
G
C
C
G
T
C
G
T
C
A
G
A
G
G
C
C
T
G
C
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C
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G
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C
C
G
T
T
G
G
G
C
T
G
G
T
C
C
G
G
G
C
T
T
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0
0.013699
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0.037182
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0.09002
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0.054795
0.02544
0.023483
0.039139
0.09589
0.043053
0.015656
0
0.007828
0
35,664
G
G
C
A
C
C
A
A
A
C
C
A
T
T
C
T
C
A
C
C
C
T
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G
G
C
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C
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G
T
G
C
T
T
C
C
G
G
A
A
C
T
C
A
A
A
G
C
T
0.017613
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0.029354
0.029354
0.04501
0.048924
0.062622
0.009785
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0.033268
0
35,665
C
T
T
T
G
A
G
T
T
C
C
G
G
A
A
G
C
A
C
C
T
G
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C
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C
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G
T
G
A
G
A
A
T
G
G
T
T
T
G
G
T
G
C
C
C
A
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0.009785
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0.033268
0
35,666
G
C
A
G
C
T
C
C
C
C
C
A
G
G
A
T
T
C
T
G
G
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C
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G
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C
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G
C
C
A
G
G
C
G
G
T
G
T
C
T
G
T
C
C
T
T
T
0.007828
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0.015656
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0.033268
0.064579
0.052838
0.011742
0.001957
0.029354
0
35,667
G
A
A
G
T
C
T
G
T
C
A
C
C
T
T
C
T
G
G
A
C
G
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C
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A
G
G
C
A
G
G
A
T
T
T
T
G
A
G
G
T
C
C
A
C
0.02544
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0.029354
0.007828
0.027397
0.033268
0.048924
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0.043053
0.048924
0.052838
0.007828
0.003914
0.029354
0
35,668
A
G
C
C
A
A
A
C
A
G
G
T
G
C
T
C
C
C
C
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C
T
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G
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C
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C
A
C
G
A
C
C
T
T
C
A
C
A
G
C
A
T
C
T
G
G
0.033268
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0.027397
0.015656
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0.031311
0.017613
0.021526
0.031311
0.048924
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0.035225
0.031311
0.035225
0.043053
0.048924
0.011742
0.003914
0.035225
0
35,669
T
C
C
C
C
T
T
T
A
G
T
A
A
A
G
C
A
G
C
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G
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G
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G
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G
T
T
C
T
G
G
G
G
T
A
T
0.023483
0.019569
0.031311
0.015656
0.017613
0.035225
0.009785
0.02544
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0
0.001957
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0.019569
0.02544
0.027397
0.041096
0.060665
0.011742
0.005871
0.031311
0
35,670
T
C
A
T
G
C
T
G
C
T
C
C
G
C
C
T
G
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C
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G
A
A
G
G
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C
A
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A
C
C
T
G
C
C
C
A
0.017613
0.009785
0.02544
0.009785
0.027397
0.037182
0.015656
0.011742
0.031311
0.052838
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0.027397
0.035225
0.037182
0.056751
0.056751
0.011742
0.001957
0.043053
0
35,671
T
C
C
C
G
A
T
C
C
C
A
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C
C
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A
G
0.011742
0.017613
0.011742
0.007828
0.009785
0.033268
0.013699
0.027397
0.017613
0.04501
0.064579
0.005871
0.017613
0.011742
0.009785
0.029354
0.084149
0.046967
0.117417
0.041096
0.021526
0.033268
0.005871
0.052838
0.019569
0.029354
0.043053
0.074364
0.04501
0.007828
0.007828
0.035225
0
35,672
T
G
G
C
A
A
G
A
T
C
C
C
T
T
C
T
C
C
T
G
C
C
C
C
T
G
C
A
G
A
T
C
T
T
A
C
T
G
C
T
A
T
C
C
T
T
A
G
C
C
T
T
G
G
A
A
A
C
T
G
C
A
G
G
A
C
0.007828
0.007828
0.035225
0.001957
0.011742
0.033268
0
0.021526
0.046967
0.046967
0.099804
0.001957
0.011742
0.007828
0.007828
0.015656
0.101761
0.052838
0.11546
0.005871
0.003914
0.005871
0.007828
0.072407
0.033268
0.041096
0.031311
0.056751
0.07045
0.001957
0.003914
0.037182
0
35,673
T
C
G
G
G
G
A
C
T
G
G
T
G
A
C
A
G
T
G
C
C
C
C
A
G
C
C
T
G
A
G
A
C
G
G
T
G
C
A
C
T
T
C
T
G
G
C
C
A
G
G
C
T
G
G
G
T
G
C
A
A
T
G
A
T
T
0.017613
0.023483
0.039139
0.017613
0.035225
0.037182
0.005871
0.033268
0.046967
0.041096
0.039139
0.013699
0.035225
0.031311
0.037182
0.043053
0.064579
0.072407
0.054795
0.003914
0.007828
0.005871
0.019569
0.037182
0.031311
0.027397
0.031311
0.039139
0.041096
0.017613
0.011742
0.037182
0
35,674
C
A
T
G
T
T
G
C
T
G
A
A
G
C
T
G
G
C
C
A
G
G
C
C
C
G
T
A
G
T
G
C
T
G
G
G
G
C
C
C
C
G
C
G
T
C
C
G
G
G
C
C
C
T
G
C
A
G
C
T
T
C
C
C
T
C
0.003914
0.013699
0.02544
0.001957
0.013699
0.031311
0.013699
0.019569
0.027397
0.052838
0.074364
0.001957
0.021526
0.021526
0.013699
0.029354
0.082192
0.058708
0.091977
0.035225
0.009785
0.015656
0.011742
0.054795
0.027397
0.02544
0.039139
0.076321
0.060665
0.009785
0
0.035225
0
35,675
C
T
G
C
T
T
C
T
T
C
A
G
G
G
A
G
A
G
C
A
G
C
T
C
C
G
C
C
G
G
A
C
C
A
C
T
C
G
C
T
C
T
G
T
T
G
T
C
C
A
T
C
C
C
A
A
G
T
A
C
C
A
C
C
A
G
0.005871
0.015656
0.031311
0.005871
0.019569
0.02544
0.011742
0.021526
0.031311
0.052838
0.074364
0.003914
0.019569
0.021526
0.021526
0.031311
0.07045
0.050881
0.078278
0.033268
0.009785
0.015656
0.011742
0.068493
0.031311
0.019569
0.037182
0.07045
0.060665
0.011742
0
0.037182
0