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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
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A
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T
G
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C
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G
C
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0
36,819
T
T
T
G
G
G
A
A
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A
A
T
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C
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C
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C
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G
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C
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A
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G
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C
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0
36,820
C
C
C
C
A
A
A
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A
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A
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A
A
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A
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36,821
C
C
C
C
T
C
T
T
G
C
T
G
A
T
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C
A
A
C
T
T
C
T
C
A
G
C
A
A
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C
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G
A
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C
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G
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G
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G
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T
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T
T
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36,822
A
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A
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A
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A
G
A
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C
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T
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0
36,823
A
C
C
C
C
C
A
G
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C
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C
A
C
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C
C
C
G
C
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C
C
C
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G
G
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C
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G
A
G
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36,824
C
A
G
A
C
C
C
T
C
A
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C
A
T
C
C
T
C
C
T
G
C
C
T
A
G
G
A
C
G
C
C
C
A
C
C
A
C
C
T
C
C
A
T
G
C
C
G
A
G
A
G
G
A
G
G
G
G
G
C
C
A
C
T
0.011742
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36,825
C
A
C
C
T
T
G
C
C
A
T
G
T
C
C
T
C
C
T
C
A
C
C
T
C
T
C
T
G
G
C
C
C
C
T
C
A
A
G
T
G
G
A
G
T
T
A
C
T
C
A
G
G
G
C
G
C
G
G
T
C
C
T
T
G
G
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0
36,826
G
G
C
C
C
C
T
C
C
C
C
A
C
A
G
A
A
A
G
C
T
G
C
T
C
C
T
G
G
A
T
G
C
C
C
C
T
G
C
A
G
A
A
G
A
C
C
C
C
A
A
T
T
A
C
C
T
G
C
C
C
C
T
C
C
T
0.013699
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0
36,827
G
T
G
A
G
G
G
T
C
A
A
C
T
T
C
T
T
C
G
G
C
C
T
G
C
T
C
A
C
T
T
T
C
C
A
G
G
C
A
C
C
G
T
T
C
C
T
G
C
C
T
T
G
G
G
C
G
C
T
C
A
T
G
G
G
G
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0.082192
0.054795
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0.031311
0
36,828
G
G
C
G
G
A
T
G
G
A
G
G
A
T
G
A
A
C
T
G
G
A
G
C
C
G
T
C
C
T
T
A
C
G
G
C
C
T
C
G
G
A
C
G
C
A
G
G
T
G
A
G
C
T
C
C
C
A
G
C
G
G
C
G
G
T
0.019569
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0
0.009785
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0.027397
0
36,829
G
C
T
C
C
C
C
T
G
C
C
A
A
G
T
C
C
C
C
G
G
A
G
C
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C
C
G
G
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C
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C
C
G
T
A
G
T
G
C
T
G
A
G
C
C
A
G
G
G
A
G
G
A
G
G
G
T
A
C
T
G
T
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0
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0
0.019569
0
36,830
A
A
C
T
T
G
T
C
C
T
C
C
A
G
C
C
A
T
T
G
C
A
G
G
G
C
C
T
G
G
T
C
C
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T
G
G
C
A
G
T
C
C
T
G
T
T
G
C
G
T
T
C
C
A
C
C
T
T
C
T
C
C
T
C
T
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0
0.041096
0
36,831
T
G
C
A
T
G
C
T
C
C
A
T
C
T
T
C
T
C
A
G
C
T
G
A
A
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C
T
T
C
C
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C
C
C
C
T
G
T
T
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T
C
T
T
T
G
G
G
A
T
C
A
G
C
A
A
C
T
G
G
C
C
A
G
T
0.023483
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0
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0
36,832
A
A
T
G
G
A
A
G
G
T
G
T
C
T
T
C
C
T
C
C
T
G
C
C
A
G
A
T
G
A
T
C
C
G
G
T
G
T
A
G
A
A
T
G
A
T
C
C
A
G
G
G
T
A
G
C
A
C
T
G
A
A
G
A
G
T
0.009785
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0.060665
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0
36,833
C
T
G
C
C
T
C
C
A
G
C
A
G
C
A
C
G
T
A
C
T
C
T
C
C
G
C
G
C
C
C
A
T
T
G
A
A
T
G
T
G
A
A
G
T
T
G
G
T
G
C
C
G
T
C
G
A
A
G
G
T
C
A
C
A
C
0.003914
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0.013699
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0
36,834
T
T
C
G
A
G
G
G
T
C
C
C
C
C
A
G
C
C
T
C
C
A
C
C
T
C
T
G
C
C
C
C
T
T
G
G
C
A
A
A
C
T
T
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A
G
C
G
T
C
T
C
T
A
C
A
A
G
G
T
G
G
T
G
G
C
0.017613
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0.02544
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0.043053
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0.023483
0.015656
0.033268
0
36,835
C
A
G
C
G
C
C
A
G
C
C
C
C
A
G
A
C
C
C
A
G
C
A
G
G
A
C
T
A
G
G
C
T
G
A
C
C
G
T
G
G
C
C
C
C
G
T
A
G
C
C
C
C
G
G
G
C
C
A
T
G
G
C
T
C
C
0.007828
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0.02544
0.068493
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0.007828
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0.021526
0
36,836
C
T
C
C
T
T
T
G
T
T
T
C
C
T
C
A
T
C
C
A
T
G
G
A
A
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G
T
T
C
T
C
C
G
T
C
C
A
C
A
T
C
A
C
C
A
G
G
A
A
C
C
C
C
G
G
C
C
T
C
C
C
T
G
C
T
0.048924
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0.052838
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0
36,837
C
G
A
G
C
A
C
C
C
G
C
T
G
A
A
C
A
T
C
A
G
C
C
T
G
G
G
A
G
A
C
G
T
G
G
T
G
C
T
G
T
A
C
A
T
G
C
C
C
A
G
T
G
C
G
C
C
G
C
T
C
A
G
C
G
C
0.009785
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0
0.017613
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0.066536
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0
0.039139
0
36,838
A
C
T
C
A
A
T
C
T
T
G
T
A
T
G
T
T
T
A
G
C
C
A
A
T
T
C
T
T
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C
A
C
A
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G
C
T
A
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A
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C
T
T
T
A
C
A
T
A
T
T
T
C
A
T
C
T
G
T
T
A
T
0.052838
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0.021526
0.027397
0.035225
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0.048924
0
36,839
T
G
G
A
T
T
T
T
T
T
T
A
A
A
G
G
T
C
T
A
A
C
A
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A
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G
A
A
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A
T
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T
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A
T
T
A
T
A
G
C
A
T
T
G
T
G
A
A
A
G
A
A
T
T
G
G
C
T
C
0.058708
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0.048924
0.050881
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0.017613
0.009785
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0.041096
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0.046967
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0.02544
0.021526
0.02544
0.037182
0.039139
0.048924
0
36,840
A
T
C
C
A
C
G
C
T
G
C
C
A
T
C
C
C
T
A
G
G
T
C
G
C
A
G
C
A
C
C
G
T
G
G
G
G
G
T
G
T
T
C
C
G
C
T
G
G
G
C
G
T
C
C
A
A
G
A
C
A
C
T
G
T
G
0.015656
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0.017613
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0.07045
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0.054795
0.066536
0
0.001957
0.035225
0
36,841
C
C
G
C
C
T
G
G
C
C
A
T
G
T
T
T
C
T
C
T
G
T
C
T
C
G
C
T
G
C
T
C
C
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C
C
A
G
C
C
C
T
C
C
A
T
C
A
C
A
A
C
A
T
C
G
T
C
C
T
T
T
T
C
A
T
0.011742
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0.031311
0.052838
0.068493
0.011742
0.003914
0.029354
0
36,842
C
C
C
G
G
T
C
A
G
C
T
C
C
C
C
T
G
T
C
T
C
A
G
G
A
C
A
C
A
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C
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G
T
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C
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C
C
A
A
G
A
G
G
A
G
G
C
A
G
G
C
C
A
A
G
A
C
A
0.017613
0.009785
0.039139
0.005871
0.029354
0.033268
0.015656
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0.027397
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0
0.003914
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0.050881
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0.029354
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0.023483
0.09589
0.048924
0.003914
0.001957
0.02544
0
36,843
T
G
G
A
G
T
G
G
T
C
C
A
C
G
C
T
G
G
T
G
C
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C
C
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C
T
G
G
T
C
C
C
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G
G
A
G
C
A
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T
C
A
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A
C
T
G
G
T
C
C
C
C
T
G
C
C
G
A
G
G
T
G
T
0.035225
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0.037182
0.021526
0.033268
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0.041096
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0.035225
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0.058708
0.013699
0.015656
0.029354
0
36,844
T
C
A
C
G
G
C
C
C
T
G
G
C
A
C
T
G
C
C
T
C
A
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G
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C
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C
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C
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C
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C
G
C
C
C
T
G
T
G
G
G
A
G
C
A
G
A
A
G
G
A
G
0.009785
0.013699
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0.048924
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0.041096
0.033268
0.050881
0.041096
0.011742
0.007828
0.041096
0
36,845
T
C
T
G
T
C
T
C
G
C
T
T
C
C
T
T
G
G
C
C
T
C
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C
A
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T
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G
C
T
T
A
A
T
G
A
A
G
C
C
C
C
C
T
G
G
G
T
0.037182
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0.054795
0.013699
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0.007828
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0.029354
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0.052838
0.013699
0.013699
0.04501
0
36,846
C
C
T
G
T
A
C
C
A
G
G
A
A
C
T
C
T
T
T
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C
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T
C
A
C
T
C
A
T
C
A
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C
A
G
G
T
A
A
C
G
G
G
G
C
C
T
T
T
T
C
C
T
A
G
T
0.043053
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0.04501
0.015656
0.019569
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0
36,847
C
T
C
T
T
T
C
C
A
T
T
C
T
T
G
A
C
T
T
T
C
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C
C
A
G
C
T
G
C
C
C
T
G
C
G
A
C
C
T
T
G
T
0.058708
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0
36,848
T
G
G
A
T
T
C
T
A
A
G
A
G
G
G
A
C
T
C
G
C
A
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T
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A
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G
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C
G
A
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T
T
T
C
G
G
G
G
A
G
T
A
G
G
G
T
T
G
T
G
C
0.031311
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0
0.009785
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0.054795
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0.021526
0
36,849
A
A
A
C
A
A
G
C
G
G
C
T
C
C
T
T
T
C
C
A
A
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C
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C
A
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A
G
G
A
C
T
C
C
A
G
A
C
A
C
C
G
C
G
0.033268
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0
36,850
G
C
T
G
T
C
A
G
C
A
C
T
T
T
T
G
A
A
G
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C
G
A
G
T
C
A
G
A
C
A
G
G
T
G
A
G
C
G
G
T
0.029354
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0.054795
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0.046967
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0.02544
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0.062622
0.009785
0.005871
0.035225
0
36,851
T
T
G
T
A
G
G
G
A
C
C
G
C
A
C
T
C
T
C
C
T
T
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G
G
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C
C
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A
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C
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C
T
G
A
T
G
C
C
T
C
C
T
C
G
G
A
G
G
C
C
A
0.011742
0.007828
0.033268
0.005871
0.017613
0.039139
0.009785
0.017613
0.033268
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0.076321
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0.019569
0.019569
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0.072407
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0.009785
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0.009785
0.060665
0.02544
0.02544
0.031311
0.080235
0.056751
0.003914
0.001957
0.027397
0
36,852
C
A
G
T
G
C
G
G
C
T
T
G
G
A
G
G
C
A
T
T
G
A
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C
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T
G
G
A
G
C
T
C
A
T
A
G
C
C
C
A
G
G
T
G
A
0.033268
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0.029354
0.039139
0.043053
0.050881
0.009785
0.015656
0.046967
0
36,853
T
C
C
T
A
C
A
G
T
T
C
C
T
G
G
G
A
A
C
A
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A
G
G
T
G
A
A
C
C
A
C
T
C
C
C
C
G
C
T
G
C
0.035225
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0.02544
0
36,854
A
T
C
A
G
G
C
T
G
A
C
G
G
C
C
T
G
G
A
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C
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C
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G
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C
C
A
C
C
T
G
C
G
G
C
A
G
G
T
T
T
G
C
T
T
C
A
0.021526
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0.048924
0.064579
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0.011742
0.013699
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0
36,855
C
A
G
C
C
T
C
C
A
C
G
A
G
C
A
G
C
A
C
C
T
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A
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T
T
C
A
G
A
G
C
T
T
G
C
T
G
A
T
G
G
G
T
T
0.033268
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0
0.019569
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0.050881
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0.013699
0.015656
0.048924
0
36,856
C
A
G
C
A
G
C
G
G
C
T
C
C
T
C
A
G
C
C
A
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C
A
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G
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T
T
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G
A
C
G
C
A
G
T
G
A
G
T
G
T
A
G
A
G
A
T
T
C
A
T
0.017613
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0.046967
0.048924
0.043053
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0.011742
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0
36,857
A
G
A
T
G
C
T
G
A
C
C
C
A
G
C
A
T
G
G
A
G
C
C
C
A
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C
A
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C
T
C
G
A
A
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A
C
C
A
T
C
C
T
G
G
C
C
A
T
A
G
C
A
G
C
C
A
A
G
C
C
G
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0.031311
0
36,858
C
T
C
A
C
T
A
C
T
T
A
C
C
A
T
G
T
T
C
C
T
G
C
G
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G
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C
A
T
C
C
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C
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G
T
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G
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G
A
G
T
C
T
C
T
G
A
A
A
A
C
A
A
A
C
A
C
A
C
C
0.037182
0.037182
0.046967
0.019569
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0.041096
0.011742
0.04501
0.037182
0.037182
0.017613
0.031311
0.02544
0
36,859
T
C
C
A
A
A
G
A
T
G
T
C
T
G
A
A
A
G
A
G
T
C
C
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G
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C
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T
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C
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C
C
A
G
A
T
G
T
T
T
T
G
T
G
A
G
A
C
A
T
C
T
0.064579
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0.033268
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0.02544
0.062622
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0
0.013699
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0.023483
0.035225
0.033268
0.033268
0.011742
0.007828
0.046967
0
36,860
G
C
C
A
C
C
T
G
A
G
G
A
A
A
T
G
T
T
C
A
G
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C
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C
A
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C
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G
G
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C
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C
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A
T
T
T
G
T
T
C
C
T
G
T
C
T
G
A
T
G
G
A
C
A
T
0.041096
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0.031311
0.027397
0.021526
0.037182
0
36,861
C
A
C
T
C
A
C
G
C
A
C
G
C
C
A
T
G
C
A
C
A
T
G
C
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G
G
C
T
C
A
C
C
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C
C
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C
C
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C
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C
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T
G
C
C
T
C
C
C
C
T
G
T
C
T
C
C
A
G
G
T
A
0.039139
0.011742
0.039139
0.02544
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0.011742
0.017613
0.078278
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0.041096
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0.043053
0.02544
0.056751
0.007828
0.015656
0.029354
0
36,862
G
C
G
A
G
C
A
G
A
T
C
C
A
G
C
T
G
A
G
G
A
G
T
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G
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A
G
C
T
G
G
G
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G
G
G
T
G
C
A
C
T
G
C
C
A
G
C
A
G
G
A
G
A
C
T
G
G
T
G
0.02544
0.013699
0.033268
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0.035225
0.023483
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0.027397
0.039139
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0.035225
0.04501
0.058708
0.007828
0.009785
0.035225
0
36,863
A
T
C
C
A
G
G
G
C
T
A
C
A
G
T
A
A
G
A
C
C
C
A
T
G
T
T
T
G
T
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T
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G
C
T
G
G
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C
T
C
A
G
A
A
A
T
G
G
A
A
T
T
T
G
G
A
G
C
T
G
A
C
T
C
0.088063
0.035225
0.043053
0.054795
0.048924
0.019569
0.005871
0.037182
0.050881
0.023483
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0
0.021526
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0.050881
0.02544
0.019569
0.015656
0.037182
0.023483
0.046967
0.033268
0
36,864
T
A
A
C
T
T
T
A
A
T
G
G
A
T
A
A
A
T
T
T
C
T
T
T
C
C
T
T
C
T
T
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T
T
C
T
C
C
A
T
C
T
T
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A
A
G
G
A
A
G
T
G
C
A
T
A
A
G
C
A
G
T
T
C
0.072407
0.037182
0.039139
0.056751
0.033268
0.019569
0.009785
0.037182
0.052838
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0
0.027397
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0.015656
0.027397
0.015656
0.039139
0.031311
0.048924
0.035225
0
36,865
A
A
C
T
T
T
A
G
G
G
G
T
C
C
C
G
T
C
G
G
C
C
G
G
G
T
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C
G
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C
G
C
G
G
C
T
G
C
C
A
C
C
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C
C
A
C
C
A
T
A
G
C
T
C
C
A
G
A
C
T
A
C
G
T
0.011742
0.005871
0.015656
0.007828
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0.031311
0.02544
0.009785
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0.093933
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0.031311
0.123288
0.031311
0.007828
0.001957
0.015656
0
36,866
T
G
G
G
T
G
T
A
G
C
C
A
T
C
C
A
G
A
A
G
C
T
C
C
A
C
C
A
T
G
T
C
C
G
C
C
G
A
G
T
C
C
C
T
G
A
T
G
T
C
A
A
A
T
A
G
G
G
G
G
A
A
G
C
T
T
0.021526
0.013699
0.054795
0.009785
0.033268
0.031311
0.019569
0.021526
0.048924
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0.043053
0.035225
0.021526
0.050881
0.048924
0.013699
0.007828
0.027397
0
36,867
T
A
G
C
C
C
G
C
T
T
C
C
A
C
G
G
G
A
G
G
A
G
C
C
G
C
C
C
A
C
C
T
C
T
G
T
C
C
T
T
C
A
A
C
G
T
C
T
C
T
C
T
G
G
A
C
T
T
C
G
T
C
A
T
C
G
0.013699
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0.017613
0.02544
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0.043053
0.033268
0.023483
0.046967
0.050881
0.017613
0.003914
0.033268
0
36,868
C
A
G
G
G
C
T
C
T
C
A
C
C
C
T
C
C
A
T
C
C
C
T
T
A
G
T
T
G
C
A
G
C
T
T
C
C
T
C
T
G
C
C
T
C
C
T
T
G
G
A
G
C
C
C
A
T
G
T
G
G
T
C
G
G
G
0.013699
0.013699
0.033268
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0.023483
0.027397
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0.027397
0.056751
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0.074364
0.060665
0.09589
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0.02544
0.050881
0.019569
0.019569
0.039139
0.076321
0.04501
0.019569
0.007828
0.031311
0
36,869
G
G
A
T
G
A
A
T
G
C
G
G
G
A
C
A
G
A
C
A
G
C
A
A
C
A
C
T
T
A
C
C
C
G
C
T
G
C
C
C
A
G
C
A
G
A
G
C
C
T
T
G
G
G
G
G
C
C
A
G
G
C
T
C
C
T
0.019569
0.013699
0.02544
0.023483
0.041096
0.019569
0.009785
0.023483
0.078278
0.027397
0.064579
0.005871
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0.017613
0.02544
0.021526
0.082192
0.048924
0.082192
0.003914
0.003914
0.009785
0.005871
0.080235
0.023483
0.043053
0.02544
0.043053
0.052838
0.015656
0.011742
0.031311
0
36,870
T
G
A
T
C
A
A
C
T
T
T
T
T
T
T
C
C
T
T
T
T
C
A
C
A
G
T
G
G
A
T
A
T
G
A
C
C
T
T
G
G
A
T
G
C
C
G
A
C
A
C
A
G
C
C
A
A
C
A
A
C
T
T
C
C
C
0.060665
0.023483
0.046967
0.037182
0.033268
0.02544
0.015656
0.031311
0.046967
0.017613
0.039139
0.019569
0.027397
0.033268
0.048924
0.037182
0.037182
0.046967
0.033268
0.011742
0.011742
0.007828
0.011742
0.041096
0.04501
0.033268
0.033268
0.027397
0.04501
0.013699
0.013699
0.043053
0
36,871
T
T
C
T
T
C
A
G
T
C
A
C
T
T
C
T
T
C
A
G
T
C
A
C
T
T
G
G
G
T
C
T
C
C
T
C
T
G
T
C
T
G
T
T
C
C
T
C
C
A
C
A
A
T
C
A
C
A
G
T
T
T
C
T
T
T
0.04501
0.013699
0.082192
0.021526
0.021526
0.015656
0.001957
0.043053
0.074364
0.017613
0.060665
0.009785
0.019569
0.007828
0.033268
0.035225
0.04501
0.041096
0.048924
0.009785
0.007828
0.003914
0.009785
0.058708
0.076321
0.029354
0.019569
0.029354
0.066536
0.003914
0.007828
0.039139
0
36,872
C
T
C
C
C
C
T
T
T
C
C
A
G
T
T
C
A
A
A
C
A
G
A
G
C
T
G
G
A
A
A
A
C
A
G
G
T
G
G
G
A
T
G
G
A
G
G
A
G
T
A
G
C
C
A
G
G
G
T
T
C
A
A
C
A
T
0.02544
0.031311
0.027397
0.033268
0.033268
0.033268
0.003914
0.027397
0.046967
0.052838
0.050881
0.011742
0.011742
0.021526
0.035225
0.029354
0.078278
0.058708
0.04501
0.009785
0.003914
0.005871
0.021526
0.050881
0.039139
0.019569
0.052838
0.037182
0.048924
0.017613
0.015656
0.019569
0
36,873
T
C
C
T
T
C
A
C
C
T
A
C
C
A
T
G
T
A
A
T
C
C
T
C
A
T
G
G
G
C
A
A
C
T
G
T
C
A
C
C
C
A
T
T
T
C
A
C
C
A
G
G
C
G
A
G
A
G
A
C
A
A
C
C
T
T
0.015656
0.021526
0.033268
0.017613
0.041096
0.052838
0.007828
0.029354
0.043053
0.029354
0.060665
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0.023483
0.043053
0.027397
0.041096
0.066536
0.058708
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0.005871
0.005871
0.007828
0.019569
0.043053
0.029354
0.029354
0.039139
0.037182
0.035225
0.037182
0.015656
0.041096
0
36,874
A
G
G
G
A
T
G
G
C
A
C
A
G
G
C
C
C
T
C
A
C
C
C
C
C
T
C
G
T
T
G
A
T
G
T
G
G
T
C
G
T
A
G
A
T
A
G
C
G
T
C
C
G
C
G
C
C
T
T
G
A
T
C
G
A
C
0.02544
0.027397
0.037182
0.019569
0.033268
0.037182
0.029354
0.027397
0.023483
0.015656
0.054795
0.019569
0.021526
0.02544
0.029354
0.035225
0.035225
0.037182
0.058708
0.021526
0.037182
0.050881
0.015656
0.033268
0.035225
0.037182
0.019569
0.043053
0.033268
0.027397
0.019569
0.033268
0
36,875
T
G
C
G
G
T
C
C
A
G
C
T
G
G
C
T
G
A
G
G
G
T
G
G
G
G
G
C
C
A
G
C
C
G
C
T
C
C
T
C
C
A
G
G
A
T
A
T
T
G
T
T
G
A
T
C
A
C
C
T
G
C
T
C
T
T
0.021526
0.015656
0.033268
0.005871
0.027397
0.029354
0.001957
0.031311
0.039139
0.043053
0.068493
0.007828
0.013699
0.023483
0.017613
0.041096
0.068493
0.066536
0.078278
0.017613
0.003914
0.011742
0.021526
0.058708
0.02544
0.019569
0.031311
0.076321
0.048924
0.013699
0.011742
0.02544
0
36,876
C
A
G
A
T
G
C
T
A
A
A
G
A
C
C
C
A
T
C
G
G
T
G
A
T
T
G
A
G
G
A
G
C
C
T
A
A
T
G
G
G
G
A
G
C
C
T
A
A
C
G
G
G
G
T
C
A
C
G
G
T
G
A
C
A
T
0.037182
0.013699
0.043053
0.009785
0.027397
0.02544
0.011742
0.02544
0.04501
0.052838
0.060665
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0.027397
0.017613
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0.037182
0.058708
0.017613
0.011742
0.009785
0.023483
0.054795
0.027397
0.039139
0.039139
0.037182
0.050881
0.007828
0.021526
0.033268
0
36,877
T
G
G
G
T
C
T
T
T
A
G
C
A
T
C
T
G
T
G
G
C
T
T
T
C
C
G
T
C
T
G
T
C
C
A
C
C
C
C
T
T
C
C
C
A
T
G
C
A
C
T
C
T
C
G
A
C
T
G
C
C
T
G
G
A
G
0.041096
0.013699
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0.009785
0.027397
0.02544
0.011742
0.029354
0.043053
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0.019569
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0.058708
0.017613
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0.027397
0.037182
0.035225
0.043053
0.050881
0.009785
0.019569
0.031311
0
36,878
G
T
G
A
G
T
G
G
A
C
A
T
G
C
G
G
A
G
G
A
A
G
G
T
G
A
G
A
A
A
A
A
C
A
C
T
T
C
G
A
T
G
G
A
G
G
C
G
C
T
T
C
T
G
C
A
T
G
T
C
A
A
C
A
A
T
0.027397
0.017613
0.039139
0.023483
0.039139
0.031311
0.007828
0.029354
0.041096
0.019569
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0.031311
0.043053
0.04501
0.050881
0.064579
0.011742
0.021526
0.013699
0.013699
0.052838
0.035225
0.035225
0.02544
0.031311
0.058708
0.011742
0.015656
0.031311
0
36,879
T
C
A
G
T
G
A
G
T
C
C
T
T
G
C
T
C
C
T
A
C
C
A
G
C
C
T
C
C
C
C
A
T
T
G
G
C
G
C
A
A
T
G
C
C
C
A
T
T
G
G
G
T
G
T
G
G
G
G
T
A
C
A
T
C
C
0.011742
0.013699
0.041096
0.011742
0.037182
0.031311
0.011742
0.029354
0.035225
0.054795
0.052838
0.005871
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0.035225
0.046967
0.076321
0.060665
0.054795
0.007828
0.011742
0.011742
0.013699
0.039139
0.023483
0.033268
0.056751
0.060665
0.029354
0.015656
0.007828
0.033268
0
36,880
T
G
G
A
G
C
C
A
G
G
G
A
G
G
G
G
G
G
C
A
T
C
T
A
G
G
G
G
C
A
G
G
C
G
G
A
T
G
G
A
T
G
G
T
G
A
A
G
G
T
T
G
T
A
G
G
G
C
A
G
G
C
C
G
G
T
0.007828
0.009785
0.037182
0.007828
0.019569
0.035225
0.001957
0.011742
0.029354
0.058708
0.060665
0.001957
0.019569
0.029354
0.029354
0.037182
0.074364
0.07045
0.099804
0.02544
0.003914
0.027397
0.007828
0.043053
0.02544
0.019569
0.054795
0.074364
0.048924
0.001957
0
0.02544
0
36,881
C
C
T
C
C
A
G
A
C
C
C
C
T
A
A
A
G
C
A
C
T
A
G
G
G
C
A
A
A
T
C
C
T
T
T
T
G
C
A
G
A
G
C
T
G
G
C
A
G
G
A
A
G
A
T
G
T
G
C
A
G
T
T
A
G
A
0.017613
0.015656
0.043053
0.019569
0.035225
0.031311
0.009785
0.017613
0.033268
0.058708
0.056751
0.013699
0.019569
0.033268
0.031311
0.041096
0.062622
0.062622
0.066536
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0.001957
0.029354
0.031311
0.041096
0.031311
0.04501
0.039139
0.058708
0.005871
0.005871
0.02544
0
36,882
C
C
T
G
G
A
T
G
A
T
G
T
C
T
C
A
C
G
A
G
C
A
G
C
T
A
A
C
T
G
C
A
C
A
T
C
T
T
C
C
T
G
C
C
A
G
C
T
C
T
G
C
A
A
A
A
G
G
A
T
T
T
G
C
C
G
0.019569
0.015656
0.043053
0.019569
0.033268
0.031311
0.009785
0.019569
0.031311
0.062622
0.054795
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0.033268
0.037182
0.062622
0.064579
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0.009785
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0.031311
0.031311
0.039139
0.031311
0.043053
0.041096
0.058708
0.007828
0.005871
0.02544
0
36,883
C
G
T
C
C
T
G
G
G
T
G
A
G
C
A
C
C
A
G
G
G
G
T
G
G
G
G
T
C
C
C
T
C
G
G
C
C
T
A
C
T
C
T
G
C
C
T
G
C
T
C
C
T
C
A
C
C
T
G
A
T
G
C
C
T
T
0.007828
0.011742
0.019569
0.009785
0.027397
0.043053
0.011742
0.021526
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0.031311
0.033268
0.048924
0.039139
0.07045
0.007828
0.003914
0.029354
0
36,884
G
A
A
G
T
A
G
T
C
C
A
G
G
C
A
C
A
C
C
G
C
A
C
A
G
G
T
C
T
C
A
G
C
A
C
C
C
G
G
A
T
C
T
G
G
G
A
G
G
C
C
C
T
G
C
G
C
T
G
C
C
C
T
G
C
T
0.007828
0.011742
0.019569
0.003914
0.023483
0.04501
0.015656
0.015656
0.02544
0.052838
0.07045
0
0.009785
0.013699
0.011742
0.054795
0.084149
0.066536
0.084149
0.031311
0.007828
0.031311
0.007828
0.050881
0.017613
0.027397
0.050881
0.074364
0.048924
0.005871
0.005871
0.023483
0
36,885
T
A
C
A
G
C
T
C
A
C
C
T
T
G
G
C
C
A
A
T
G
C
C
T
C
C
T
T
C
T
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C
C
T
G
G
G
G
C
T
C
A
G
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C
G
C
C
G
A
C
T
C
T
G
C
C
G
C
T
C
A
T
C
T
0.013699
0.007828
0.02544
0.001957
0.011742
0.019569
0.011742
0.011742
0.019569
0.054795
0.060665
0
0.017613
0.011742
0.017613
0.023483
0.048924
0.050881
0.105675
0.074364
0.02544
0.068493
0.003914
0.066536
0.011742
0.017613
0.02544
0.111546
0.054795
0.005871
0.005871
0.013699
0
36,886
T
A
T
A
G
G
A
A
G
C
C
G
T
G
T
G
A
G
A
C
C
A
C
C
T
C
T
T
T
C
T
T
C
C
C
T
C
T
G
C
T
C
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C
A
G
C
A
A
A
C
T
C
C
T
C
A
T
C
C
T
T
C
C
T
0.029354
0.02544
0.041096
0.017613
0.035225
0.035225
0.003914
0.033268
0.039139
0.043053
0.058708
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0.048924
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0.037182
0.02544
0.033268
0.031311
0.052838
0.017613
0.015656
0.035225
0
36,887
C
G
G
T
C
T
A
G
C
C
T
C
G
T
G
C
C
C
C
T
T
G
T
C
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A
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T
T
T
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C
T
G
C
C
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C
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C
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C
C
A
G
C
T
G
G
A
T
T
A
A
G
T
G
T
C
T
C
G
0.009785
0.013699
0.027397
0.005871
0.054795
0.037182
0.003914
0.039139
0.029354
0.035225
0.048924
0.007828
0.011742
0.019569
0.027397
0.068493
0.072407
0.074364
0.068493
0.021526
0.005871
0.027397
0.023483
0.029354
0.013699
0.039139
0.04501
0.060665
0.04501
0.013699
0.005871
0.013699
0
36,888
G
G
G
G
A
G
C
G
A
C
A
G
C
G
G
G
C
A
G
G
G
G
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G
A
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G
T
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C
A
G
C
G
C
T
A
T
A
A
C
G
C
C
C
A
C
A
T
G
0.011742
0.021526
0.015656
0.011742
0.035225
0.039139
0.009785
0.02544
0.043053
0.043053
0.056751
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0.007828
0.041096
0.072407
0.041096
0.062622
0.019569
0.013699
0.019569
0.023483
0.054795
0.031311
0.031311
0.037182
0.041096
0.037182
0.015656
0.009785
0.048924
0
36,889
A
C
T
A
C
T
T
A
C
T
T
C
C
C
A
A
C
A
C
A
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C
C
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C
G
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G
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C
T
C
A
G
G
A
A
T
G
G
C
T
T
C
A
T
G
A
G
G
T
0.035225
0.043053
0.021526
0.048924
0.041096
0.043053
0.001957
0.031311
0.027397
0.035225
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0.023483
0.023483
0.043053
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0.04501
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0.035225
0
0.003914
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0.027397
0.041096
0.02544
0.023483
0.027397
0.021526
0.043053
0.021526
0.029354
0.039139
0
36,890
T
C
C
C
A
G
A
A
T
C
A
C
A
A
T
C
T
T
C
C
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C
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C
T
T
G
A
C
C
A
A
G
T
T
G
A
A
G
G
C
C
A
T
0.019569
0.019569
0.039139
0.017613
0.037182
0.039139
0.023483
0.027397
0.04501
0.035225
0.050881
0.015656
0.013699
0.023483
0.027397
0.054795
0.054795
0.056751
0.054795
0.011742
0.007828
0.007828
0.015656
0.048924
0.029354
0.035225
0.035225
0.039139
0.043053
0.019569
0.019569
0.031311
0
36,891
A
C
T
C
A
T
G
A
A
C
G
A
C
T
T
G
A
C
C
A
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T
G
G
G
G
C
T
G
A
A
A
C
A
C
A
T
G
T
A
A
T
0.023483
0.023483
0.039139
0.021526
0.039139
0.041096
0.021526
0.02544
0.043053
0.035225
0.050881
0.017613
0.013699
0.02544
0.031311
0.052838
0.060665
0.062622
0.046967
0.007828
0.007828
0.005871
0.011742
0.043053
0.033268
0.035225
0.033268
0.039139
0.041096
0.013699
0.019569
0.033268
0
36,892
C
T
G
C
T
G
C
T
G
G
G
G
G
C
T
C
A
G
G
T
C
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C
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C
C
C
G
C
G
G
G
C
G
C
A
G
A
A
A
G
G
C
T
C
A
C
0.009785
0.015656
0.011742
0.001957
0.017613
0.033268
0.011742
0.013699
0.029354
0.050881
0.064579
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0.009785
0.013699
0.019569
0.027397
0.082192
0.056751
0.084149
0.052838
0.011742
0.060665
0.003914
0.060665
0.011742
0.023483
0.048924
0.093933
0.046967
0.009785
0
0.019569
0
36,893
C
C
C
T
A
C
C
C
C
A
G
C
C
C
C
A
C
G
C
T
C
T
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T
C
C
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T
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C
C
T
T
G
G
A
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C
C
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C
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C
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G
G
A
G
G
A
A
G
T
A
G
T
C
A
T
C
A
G
G
A
C
0.037182
0.027397
0.029354
0.027397
0.031311
0.035225
0.005871
0.029354
0.04501
0.019569
0.050881
0.029354
0.039139
0.037182
0.039139
0.021526
0.052838
0.04501
0.048924
0.015656
0.007828
0.009785
0.013699
0.050881
0.027397
0.037182
0.02544
0.023483
0.052838
0.015656
0.019569
0.048924
0
36,894
C
T
T
C
T
C
T
A
C
C
A
G
A
T
G
G
C
T
G
T
C
C
A
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C
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C
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G
T
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C
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A
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A
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A
A
A
A
T
G
G
T
A
C
A
A
A
T
G
A
G
G
T
C
C
0.035225
0.013699
0.050881
0.011742
0.02544
0.04501
0.007828
0.027397
0.062622
0.041096
0.050881
0.015656
0.015656
0.031311
0.031311
0.043053
0.052838
0.072407
0.043053
0.003914
0
0.003914
0.023483
0.054795
0.033268
0.017613
0.043053
0.041096
0.041096
0.031311
0.011742
0.017613
0
36,895
A
C
T
C
A
C
C
T
T
G
C
A
A
C
A
G
T
G
G
G
G
T
G
T
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G
G
G
G
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C
T
C
G
G
A
G
A
A
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C
T
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C
C
A
G
A
A
C
T
C
C
C
T
T
T
C
T
C
C
G
G
C
C
T
0.060665
0.027397
0.048924
0.019569
0.039139
0.029354
0.003914
0.031311
0.037182
0.035225
0.056751
0.019569
0.021526
0.017613
0.039139
0.04501
0.046967
0.046967
0.056751
0.011742
0.005871
0.001957
0.017613
0.043053
0.039139
0.019569
0.023483
0.04501
0.041096
0.011742
0.017613
0.039139
0
36,896
C
A
G
C
T
C
T
T
C
A
G
C
T
G
C
C
C
G
G
G
C
C
A
C
C
G
G
C
T
C
C
A
C
G
G
T
G
G
C
T
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C
A
G
C
T
A
C
C
T
C
G
G
C
T
G
C
C
T
G
G
G
T
C
A
T
0.005871
0.001957
0.019569
0.001957
0.009785
0.041096
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0.019569
0.019569
0.086106
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0.011742
0.013699
0.043053
0.091977
0.058708
0.082192
0.066536
0.011742
0.021526
0.007828
0.056751
0.007828
0.019569
0.064579
0.105675
0.027397
0.011742
0.001957
0.027397
0
36,897
C
A
C
T
G
C
T
G
C
A
G
C
G
A
G
A
G
G
C
T
C
T
G
C
T
G
G
C
T
C
T
G
C
T
T
C
C
A
T
C
T
G
C
A
G
G
G
T
G
G
G
G
A
G
A
G
G
G
C
A
T
G
G
A
C
G
0.015656
0.013699
0.031311
0.023483
0.017613
0.02544
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0.037182
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0.02544
0.068493
0.058708
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0.015656
0.021526
0.043053
0.02544
0.021526
0.048924
0.052838
0.041096
0.015656
0.013699
0.041096
0
36,898
G
C
C
A
G
C
A
G
A
G
C
C
T
C
T
C
G
C
T
G
C
A
G
C
A
G
T
G
G
A
A
G
C
G
G
C
C
A
A
T
G
G
G
G
C
T
G
A
G
C
A
G
A
C
C
C
G
A
G
T
G
A
A
C
A
T
0.017613
0.013699
0.037182
0.009785
0.015656
0.02544
0.011742
0.023483
0.037182
0.068493
0.046967
0.017613
0.029354
0.037182
0.029354
0.027397
0.07045
0.056751
0.050881
0.021526
0.009785
0.015656
0.019569
0.048924
0.027397
0.023483
0.052838
0.054795
0.043053
0.011742
0.005871
0.039139
0
36,899
G
A
G
A
A
G
A
G
A
A
A
G
T
G
A
C
G
G
C
A
C
A
G
T
T
G
A
A
G
A
C
A
C
G
G
A
G
A
G
A
G
A
G
C
T
C
A
A
G
G
A
A
G
A
G
C
C
G
G
A
G
G
A
G
G
T
0.017613
0.007828
0.031311
0.003914
0.027397
0.035225
0.011742
0.021526
0.039139
0.02544
0.072407
0.005871
0.027397
0.033268
0.015656
0.058708
0.058708
0.060665
0.07045
0.023483
0.011742
0.011742
0.005871
0.062622
0.023483
0.023483
0.046967
0.068493
0.054795
0.005871
0.005871
0.031311
0
36,900
C
T
T
T
C
T
A
G
C
T
G
A
T
G
T
C
T
G
T
C
C
C
A
C
A
G
A
G
G
C
T
G
C
G
C
C
T
G
A
T
G
C
C
G
T
G
G
A
T
G
C
T
G
G
A
G
C
C
A
G
G
G
C
C
T
T
0.007828
0.015656
0.019569
0.001957
0.021526
0.029354
0.005871
0.011742
0.046967
0.046967
0.082192
0
0.027397
0.017613
0.019569
0.02544
0.093933
0.076321
0.097847
0.017613
0.003914
0.003914
0.009785
0.064579
0.017613
0.02544
0.037182
0.088063
0.060665
0.001957
0
0.021526
0
36,901
C
C
A
C
C
A
C
A
T
C
A
G
A
A
A
G
G
G
T
C
C
A
A
G
C
G
C
C
C
C
A
G
C
A
A
A
G
C
C
A
A
C
A
C
C
A
C
A
G
C
C
C
T
C
C
A
G
G
A
C
C
C
T
A
T
G
0.02544
0.021526
0.027397
0.013699
0.035225
0.046967
0.003914
0.011742
0.021526
0.041096
0.076321
0.001957
0.013699
0.027397
0.023483
0.048924
0.064579
0.074364
0.09589
0.011742
0.011742
0.007828
0.011742
0.046967
0.033268
0.019569
0.031311
0.056751
0.058708
0.007828
0.005871
0.021526
0
36,902
G
A
G
A
G
A
A
G
A
G
A
G
G
A
T
G
G
A
C
C
A
T
G
C
C
T
G
G
C
A
C
A
C
T
G
T
G
G
T
G
T
G
G
A
G
T
T
G
G
A
G
A
T
T
C
T
G
C
T
G
G
G
A
A
C
G
0.011742
0.011742
0.031311
0.013699
0.021526
0.035225
0.005871
0.031311
0.041096
0.056751
0.04501
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0.019569
0.033268
0.015656
0.054795
0.056751
0.058708
0.074364
0.023483
0.015656
0.009785
0.007828
0.078278
0.029354
0.023483
0.039139
0.039139
0.052838
0.005871
0.011742
0.041096
0
36,903
T
G
C
T
G
G
A
C
T
C
T
C
C
T
C
A
A
G
C
G
C
T
C
G
G
C
A
T
G
C
C
T
C
C
C
A
C
T
G
A
C
T
C
T
G
A
A
G
A
G
T
G
G
C
C
A
G
T
G
C
T
C
T
C
T
G
0.001957
0.007828
0.027397
0.001957
0.019569
0.031311
0.003914
0.031311
0.035225
0.064579
0.054795
0.001957
0.019569
0.035225
0.013699
0.046967
0.074364
0.066536
0.068493
0.02544
0.013699
0.015656
0.009785
0.076321
0.021526
0.021526
0.050881
0.056751
0.058708
0.009785
0.001957
0.031311
0
36,904
G
G
A
G
G
A
T
A
G
G
C
C
C
A
C
C
T
A
C
C
G
G
A
A
G
C
A
A
G
A
G
C
C
G
T
G
C
C
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G
G
T
T
T
C
G
T
T
G
A
C
A
G
T
C
C
T
G
T
A
C
C
A
T
A
T
0.035225
0.029354
0.04501
0.02544
0.039139
0.039139
0.003914
0.021526
0.046967
0.037182
0.054795
0.013699
0.023483
0.039139
0.041096
0.035225
0.048924
0.060665
0.04501
0.005871
0.001957
0
0.021526
0.04501
0.037182
0.015656
0.031311
0.041096
0.041096
0.023483
0.019569
0.031311
0
36,905
C
A
G
C
C
A
G
A
C
T
C
C
A
G
T
T
G
A
C
C
C
T
C
A
G
G
A
G
G
G
C
A
C
C
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C
C
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C
C
C
T
T
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T
G
G
G
C
C
A
G
G
C
C
G
G
G
A
C
T
C
C
T
G
G
0.035225
0.021526
0.031311
0.011742
0.037182
0.035225
0.001957
0.027397
0.031311
0.043053
0.068493
0.009785
0.021526
0.027397
0.02544
0.043053
0.068493
0.052838
0.072407
0.005871
0.005871
0.005871
0.02544
0.046967
0.02544
0.023483
0.043053
0.04501
0.046967
0.013699
0.013699
0.033268
0
36,906
A
G
C
G
A
T
T
C
C
A
T
C
A
T
G
T
C
A
C
T
G
T
G
C
T
C
C
A
G
A
T
A
T
A
C
T
T
C
T
G
T
G
A
C
T
G
G
C
A
G
C
A
G
G
C
C
T
G
G
G
A
G
C
G
G
C
0.052838
0.031311
0.031311
0.011742
0.068493
0.009785
0.007828
0.039139
0.041096
0.046967
0.033268
0.015656
0.023483
0.035225
0.02544
0.060665
0.07045
0.046967
0.023483
0.003914
0.007828
0.019569
0.009785
0.050881
0.029354
0.015656
0.037182
0.043053
0.031311
0.017613
0.019569
0.039139
0
36,907
T
C
C
A
G
A
T
A
T
A
C
T
T
C
T
G
T
G
A
C
T
G
G
C
A
G
C
A
G
G
C
C
T
G
G
G
A
G
C
G
G
A
G
G
G
A
G
A
G
C
T
T
G
T
A
C
G
C
T
C
A
C
C
A
T
C
0.064579
0.031311
0.033268
0.019569
0.068493
0.009785
0.007828
0.037182
0.043053
0.04501
0.031311
0.015656
0.023483
0.035225
0.027397
0.056751
0.064579
0.043053
0.023483
0.003914
0.007828
0.019569
0.009785
0.048924
0.029354
0.017613
0.031311
0.037182
0.029354
0.017613
0.027397
0.039139
0
36,908
G
C
C
A
C
A
T
G
A
A
C
C
A
A
G
A
C
C
T
A
T
A
C
A
G
A
A
G
C
T
G
T
C
G
C
T
C
T
G
C
G
T
G
A
A
G
G
A
T
G
G
C
C
T
G
A
G
G
C
A
G
G
A
C
A
T
0.02544
0.015656
0.04501
0.013699
0.041096
0.017613
0.011742
0.027397
0.04501
0.050881
0.07045
0.007828
0.009785
0.019569
0.02544
0.04501
0.088063
0.054795
0.023483
0.007828
0.003914
0.007828
0.011742
0.048924
0.039139
0.027397
0.046967
0.07045
0.04501
0.009785
0.009785
0.033268
0
36,909
G
C
T
G
G
G
C
T
G
A
C
C
T
C
C
G
G
C
T
G
C
A
G
T
C
C
C
A
C
C
A
G
C
G
C
T
G
A
A
A
C
C
A
G
G
T
C
C
G
C
A
G
A
C
A
G
C
C
T
A
A
G
G
C
A
T
0.019569
0.02544
0.019569
0.005871
0.039139
0.048924
0.003914
0.033268
0.04501
0.043053
0.04501
0.005871
0.015656
0.027397
0.019569
0.054795
0.097847
0.07045
0.04501
0.023483
0
0.007828
0.011742
0.037182
0.02544
0.037182
0.060665
0.046967
0.043053
0.007828
0.005871
0.027397
0