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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
A
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A
A
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A
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A
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C
A
A
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A
A
A
A
A
A
A
A
T
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C
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A
A
A
A
A
T
A
C
T
C
A
C
A
T
G
T
A
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A
C
G
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C
C
A
T
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T
T
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G
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T
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A
G
A
G
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G
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36,915
G
T
C
T
T
G
A
C
A
T
G
G
T
C
C
A
A
A
G
A
C
T
T
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C
T
T
T
T
G
A
T
G
C
A
G
C
C
C
T
G
T
T
G
T
A
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C
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T
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T
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C
A
T
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0
36,916
G
A
G
A
A
A
G
A
A
A
T
A
C
A
T
C
T
T
A
C
A
A
T
A
T
C
T
G
A
T
G
T
C
A
T
A
T
T
C
T
C
C
T
C
C
A
C
A
C
C
G
C
C
G
T
G
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C
A
G
A
C
G
C
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0.054795
0
36,917
G
C
T
C
A
A
G
A
C
A
C
C
T
T
G
A
T
C
A
C
C
A
T
T
A
G
G
T
G
G
A
A
C
T
G
A
A
G
G
A
G
C
C
A
A
A
A
A
T
G
G
G
C
G
C
A
A
T
G
G
C
T
C
C
T
T
0.07045
0.019569
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0.041096
0
36,918
T
A
C
G
C
T
C
C
T
G
A
A
T
G
T
A
T
A
G
A
C
A
T
G
G
G
A
A
C
C
A
C
T
T
T
C
A
G
C
A
T
C
A
A
A
A
A
A
G
G
A
A
A
C
G
T
T
C
T
G
C
A
T
G
C
C
0.058708
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0.027397
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0.031311
0.054795
0.021526
0.015656
0.035225
0
36,919
G
A
G
T
T
T
G
A
G
G
G
A
T
G
G
A
G
G
C
C
G
C
C
T
C
T
C
T
G
C
C
A
C
C
A
C
G
G
T
G
C
C
G
C
T
G
A
C
T
T
T
C
C
T
C
T
T
C
G
T
A
G
A
C
C
G
0.037182
0.019569
0.031311
0.019569
0.02544
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0.043053
0.033268
0.058708
0.011742
0.005871
0.039139
0
36,920
T
G
A
T
T
T
T
G
T
T
C
T
T
C
C
G
A
G
A
G
A
C
C
A
T
G
G
A
A
G
A
G
C
A
A
C
A
G
C
A
A
A
G
T
A
G
A
T
C
C
T
C
C
C
C
A
T
G
G
G
G
C
T
C
C
T
0.04501
0.021526
0.050881
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0.003914
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0.013699
0.029354
0
36,921
C
T
G
C
A
G
T
G
A
A
T
T
A
A
T
G
C
A
C
T
T
G
A
G
G
C
A
G
A
C
G
G
C
G
C
A
T
C
C
A
C
A
C
T
C
C
A
G
G
G
A
C
A
T
T
G
G
T
T
T
T
T
C
C
A
T
0.043053
0.021526
0.054795
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0.048924
0.019569
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0.031311
0
36,922
A
A
A
G
C
C
T
C
A
T
C
A
G
G
T
T
A
G
A
G
G
G
T
G
T
G
G
A
A
G
G
G
C
G
T
G
A
C
C
C
A
G
T
G
G
G
A
G
G
T
G
G
G
A
A
T
C
T
C
A
C
C
A
A
T
T
0.054795
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0.015656
0.029354
0.035225
0.019569
0.064579
0.04501
0
36,923
G
G
A
G
T
G
A
G
A
A
C
A
T
G
C
G
G
T
A
T
T
T
A
T
C
T
T
T
C
T
G
G
T
C
C
T
G
A
T
T
T
A
T
T
T
T
G
C
T
T
A
A
C
A
T
A
A
T
G
T
C
C
T
C
C
A
0.076321
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0.013699
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0.035225
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0.054795
0.033268
0
36,924
T
C
C
T
A
T
A
G
T
A
C
C
T
C
G
G
T
T
G
G
T
C
T
T
C
A
G
C
A
T
C
G
C
C
T
G
A
G
C
A
G
A
A
G
G
G
A
A
G
A
C
A
G
G
T
G
A
G
G
G
T
C
A
A
G
T
0.058708
0.02544
0.04501
0.023483
0.029354
0.037182
0.003914
0.035225
0.048924
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0.023483
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0.035225
0.027397
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0.039139
0
36,925
G
T
G
T
C
T
T
T
T
G
G
T
G
G
G
C
G
T
T
T
C
A
G
A
A
A
G
T
A
G
A
A
C
G
G
G
G
A
C
A
G
A
A
A
G
C
T
T
G
G
A
T
C
C
G
G
A
C
C
A
G
G
T
C
T
T
0.076321
0.035225
0.039139
0.050881
0.035225
0.021526
0.009785
0.037182
0.039139
0.027397
0.039139
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0.027397
0.027397
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0.031311
0.007828
0
0.005871
0.029354
0.029354
0.04501
0.019569
0.02544
0.019569
0.033268
0.021526
0.050881
0.04501
0
36,926
G
T
T
G
G
T
G
G
C
G
G
C
C
A
T
G
G
A
G
A
C
T
A
A
A
G
A
C
T
C
A
G
C
G
C
T
G
G
A
G
T
G
G
T
A
G
G
A
G
G
G
C
G
G
C
A
A
T
G
A
A
A
A
C
T
T
0.021526
0.02544
0.02544
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0.015656
0.011742
0.058708
0.09002
0.033268
0.013699
0.007828
0.019569
0
36,927
C
T
G
C
A
G
C
G
A
A
T
T
G
A
T
G
C
A
C
T
T
G
A
G
G
C
A
G
A
C
G
G
T
G
C
A
T
C
C
A
C
A
C
T
C
C
A
G
G
G
A
C
A
T
T
G
G
T
T
T
T
T
C
C
A
C
0.039139
0.027397
0.052838
0.021526
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0.02544
0.046967
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0.050881
0.02544
0.043053
0.021526
0.052838
0.017613
0.003914
0.033268
0
36,928
T
G
G
G
G
A
G
G
A
T
C
T
G
C
T
T
T
G
C
T
G
T
T
G
C
T
G
T
T
C
C
A
T
G
G
T
C
T
C
T
C
A
G
A
G
G
A
A
C
A
A
A
A
T
C
A
G
G
C
C
C
A
A
T
C
C
0.039139
0.023483
0.048924
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0.039139
0.023483
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0.021526
0.048924
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0.050881
0.023483
0.050881
0.027397
0.050881
0.011742
0.007828
0.037182
0
36,929
T
G
G
T
T
T
C
C
C
A
C
A
T
C
A
A
G
G
A
A
C
T
G
G
A
G
C
C
C
A
A
G
C
T
G
A
A
G
A
A
G
A
T
T
C
T
A
C
A
G
A
T
G
A
A
C
C
C
A
A
G
G
A
T
G
A
0.043053
0.027397
0.035225
0.027397
0.04501
0.02544
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0.015656
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0.043053
0.027397
0.046967
0.027397
0.046967
0.007828
0.005871
0.039139
0
36,930
C
A
G
A
C
C
A
G
G
A
A
A
A
A
T
C
A
T
C
T
G
T
G
C
A
G
T
T
G
G
C
C
C
C
T
C
A
T
T
C
C
A
C
A
T
G
G
G
G
A
T
T
A
G
C
T
G
C
T
G
T
C
T
G
G
G
0.04501
0.033268
0.037182
0.033268
0.043053
0.02544
0
0.015656
0.052838
0.039139
0.037182
0.007828
0.052838
0.046967
0.043053
0.021526
0.060665
0.046967
0.052838
0.007828
0.005871
0.005871
0.019569
0.027397
0.043053
0.021526
0.037182
0.023483
0.043053
0.009785
0.017613
0.043053
0
36,931
C
T
G
G
C
A
C
C
T
A
A
A
A
T
T
G
A
G
A
T
G
C
T
T
C
A
T
C
A
T
C
A
C
A
T
T
C
T
C
A
G
C
C
C
T
G
A
C
A
A
C
A
C
A
T
A
G
A
A
T
C
A
C
C
T
G
0.054795
0.035225
0.035225
0.037182
0.041096
0.027397
0
0.019569
0.056751
0.037182
0.035225
0.009785
0.046967
0.04501
0.04501
0.019569
0.054795
0.043053
0.046967
0.007828
0.003914
0.003914
0.027397
0.031311
0.04501
0.021526
0.031311
0.021526
0.037182
0.011742
0.017613
0.048924
0
36,932
A
T
T
C
T
G
T
G
C
T
T
G
T
T
C
C
C
A
C
G
T
C
C
A
C
C
T
C
C
C
A
G
T
A
G
T
G
G
C
G
G
C
C
A
C
A
G
G
T
A
A
A
G
C
G
A
G
G
G
G
A
G
C
C
C
C
0.043053
0.02544
0.04501
0.015656
0.031311
0.021526
0.019569
0.033268
0.046967
0.035225
0.039139
0.011742
0.029354
0.027397
0.037182
0.039139
0.056751
0.052838
0.033268
0.019569
0.013699
0.013699
0.007828
0.04501
0.043053
0.031311
0.041096
0.035225
0.054795
0.009785
0.005871
0.035225
0
36,933
C
G
T
G
G
A
A
A
C
T
T
G
G
C
T
G
C
T
G
C
T
T
T
G
A
G
G
A
T
G
T
T
T
C
A
T
A
C
T
T
C
A
G
G
T
C
G
G
T
G
G
A
A
A
T
C
A
A
A
A
G
G
A
A
A
G
0.062622
0.02544
0.062622
0.033268
0.029354
0.027397
0.013699
0.033268
0.041096
0.033268
0.046967
0.013699
0.023483
0.019569
0.041096
0.031311
0.052838
0.041096
0.035225
0.009785
0.009785
0.005871
0.005871
0.031311
0.050881
0.029354
0.029354
0.029354
0.041096
0.017613
0.029354
0.043053
0
36,934
T
T
T
T
A
G
C
A
A
A
A
T
T
G
C
A
G
C
A
A
G
G
A
T
T
T
C
C
T
C
T
G
T
C
C
A
A
T
C
C
A
C
A
C
A
A
A
T
T
C
T
T
A
T
T
C
G
T
C
A
A
T
T
C
A
C
0.111546
0.039139
0.04501
0.052838
0.048924
0.021526
0.005871
0.02544
0.052838
0.037182
0.035225
0.023483
0.023483
0.013699
0.064579
0.021526
0.043053
0.027397
0.013699
0.001957
0.003914
0
0.021526
0.041096
0.029354
0.023483
0.035225
0.013699
0.029354
0.017613
0.043053
0.033268
0
36,935
A
A
C
T
C
T
C
C
T
C
A
C
C
T
C
T
T
C
G
G
T
G
G
A
G
A
G
A
G
T
G
A
C
A
T
T
G
A
A
A
A
C
C
C
C
A
G
C
T
G
T
G
A
A
A
T
G
A
G
C
A
A
A
G
G
G
0.062622
0.02544
0.043053
0.050881
0.031311
0.033268
0.005871
0.033268
0.056751
0.021526
0.033268
0.021526
0.027397
0.029354
0.031311
0.037182
0.041096
0.043053
0.035225
0.009785
0.013699
0.005871
0.015656
0.046967
0.060665
0.02544
0.019569
0.007828
0.04501
0.015656
0.02544
0.04501
0
36,936
G
G
C
C
C
G
G
C
C
T
C
C
C
G
G
G
G
G
C
T
C
T
G
G
T
C
C
C
C
T
C
C
T
C
G
G
T
G
A
G
T
C
A
T
G
G
C
T
T
C
T
G
G
T
T
T
T
G
C
A
G
T
A
A
A
G
0.035225
0.029354
0.029354
0.023483
0.015656
0.033268
0.015656
0.023483
0.021526
0.041096
0.035225
0.005871
0.013699
0.015656
0.031311
0.031311
0.039139
0.048924
0.084149
0.066536
0.015656
0.043053
0.009785
0.043053
0.035225
0.019569
0.027397
0.068493
0.048924
0.007828
0.015656
0.02544
0
36,937
C
C
T
T
G
G
A
A
T
G
A
A
T
C
A
C
T
T
G
G
T
T
G
T
T
C
A
T
C
C
T
G
C
A
T
G
C
T
A
G
T
C
T
G
A
T
T
G
G
A
G
C
T
G
G
T
G
G
C
C
A
A
A
G
A
T
0.054795
0.02544
0.035225
0.054795
0.035225
0.02544
0.001957
0.037182
0.050881
0.019569
0.02544
0.060665
0.041096
0.039139
0.043053
0.029354
0.048924
0.046967
0.017613
0.001957
0.007828
0.005871
0.017613
0.029354
0.046967
0.027397
0.023483
0.017613
0.031311
0.017613
0.02544
0.054795
0
36,938
A
C
C
T
T
T
G
C
T
G
C
T
G
T
G
G
A
G
A
T
C
C
G
G
A
C
T
G
G
G
G
G
C
T
C
A
G
G
G
G
C
T
G
C
T
G
G
C
C
T
T
G
T
G
G
G
G
A
G
A
G
C
C
T
C
T
0.050881
0.021526
0.039139
0.021526
0.027397
0.031311
0.003914
0.021526
0.033268
0.048924
0.056751
0.027397
0.023483
0.019569
0.027397
0.031311
0.058708
0.054795
0.064579
0.019569
0.003914
0.007828
0.019569
0.04501
0.031311
0.007828
0.029354
0.054795
0.04501
0.023483
0.023483
0.02544
0
36,939
C
T
T
T
A
G
G
A
T
C
G
C
C
T
C
A
A
T
G
G
A
G
A
A
G
G
A
C
A
G
G
C
T
C
A
G
C
T
T
C
T
T
C
G
G
G
G
C
C
T
C
A
C
A
G
C
A
C
C
C
C
A
A
G
C
C
0.027397
0.011742
0.041096
0.011742
0.02544
0.029354
0.007828
0.019569
0.060665
0.041096
0.074364
0.013699
0.019569
0.017613
0.015656
0.033268
0.068493
0.056751
0.058708
0.009785
0.005871
0.011742
0.015656
0.07045
0.039139
0.027397
0.019569
0.056751
0.054795
0.009785
0.011742
0.033268
0
36,940
T
G
G
A
C
A
G
A
C
C
A
G
A
A
G
G
G
C
C
A
G
G
T
G
A
A
G
A
G
G
G
C
C
C
C
G
G
A
G
A
A
G
C
T
G
C
G
G
C
C
T
C
A
G
G
C
T
C
T
G
G
G
C
T
A
T
0.037182
0.011742
0.04501
0.015656
0.021526
0.035225
0.003914
0.017613
0.060665
0.050881
0.068493
0.019569
0.015656
0.011742
0.021526
0.029354
0.074364
0.054795
0.056751
0.009785
0.003914
0.005871
0.015656
0.064579
0.041096
0.02544
0.021526
0.054795
0.043053
0.011742
0.011742
0.039139
0
36,941
A
T
C
C
A
C
T
G
C
T
C
T
G
C
G
C
A
G
G
C
T
G
G
C
T
C
C
T
C
C
C
A
C
G
A
G
C
T
G
T
T
G
T
C
C
A
T
C
G
G
C
T
C
A
A
G
A
T
C
A
G
C
T
G
G
T
0.019569
0.023483
0.033268
0.005871
0.037182
0.035225
0.007828
0.023483
0.043053
0.052838
0.054795
0.003914
0.031311
0.041096
0.027397
0.046967
0.068493
0.07045
0.048924
0.001957
0.003914
0.009785
0.017613
0.054795
0.027397
0.023483
0.048924
0.029354
0.062622
0.009785
0.007828
0.027397
0
36,942
C
T
G
C
G
C
T
C
T
G
G
G
C
T
C
G
A
C
T
G
A
G
G
C
T
C
C
C
T
G
G
C
C
G
C
T
C
G
C
G
C
T
T
T
T
C
T
C
T
C
C
T
T
C
T
C
C
A
A
G
A
T
G
G
C
T
0.019569
0.009785
0.027397
0.021526
0.011742
0.017613
0.007828
0.021526
0.033268
0.056751
0.041096
0.011742
0.017613
0.011742
0.015656
0.019569
0.046967
0.035225
0.078278
0.062622
0.039139
0.07045
0.013699
0.064579
0.02544
0.021526
0.027397
0.088063
0.035225
0.007828
0.017613
0.021526
0
36,943
A
G
A
G
A
G
G
T
T
T
C
A
T
T
T
T
T
T
T
C
G
A
T
T
T
G
T
G
G
G
A
G
C
C
A
C
C
A
T
C
C
T
C
T
A
G
G
G
G
T
A
G
T
T
C
C
C
C
A
C
T
G
C
T
T
A
0.086106
0.019569
0.050881
0.02544
0.033268
0.017613
0.003914
0.035225
0.052838
0.048924
0.037182
0.019569
0.027397
0.021526
0.02544
0.031311
0.050881
0.039139
0.037182
0.009785
0.015656
0.001957
0.021526
0.050881
0.058708
0.02544
0.013699
0.017613
0.050881
0.013699
0.013699
0.043053
0
36,944
C
C
C
G
A
A
A
A
G
A
C
A
T
A
A
C
A
G
T
G
C
T
C
C
G
G
G
A
A
A
G
T
T
G
G
C
T
G
T
C
T
A
A
T
T
A
C
A
A
T
A
T
T
G
G
A
G
A
A
T
T
A
G
A
A
C
0.072407
0.033268
0.043053
0.048924
0.048924
0.017613
0.011742
0.027397
0.046967
0.029354
0.029354
0.023483
0.027397
0.041096
0.043053
0.023483
0.041096
0.039139
0.031311
0.009785
0.007828
0.001957
0.019569
0.029354
0.041096
0.029354
0.027397
0.023483
0.037182
0.019569
0.039139
0.035225
0
36,945
T
T
T
T
G
T
G
G
C
C
A
A
G
A
G
A
C
A
C
A
T
C
C
C
T
T
T
C
T
G
G
A
C
G
G
C
T
A
G
A
G
G
G
G
T
G
C
A
G
A
G
A
G
C
C
T
T
T
G
A
G
G
G
C
A
T
0.033268
0.009785
0.050881
0.02544
0.031311
0.029354
0.003914
0.013699
0.052838
0.07045
0.039139
0.011742
0.021526
0.039139
0.035225
0.033268
0.064579
0.060665
0.027397
0.017613
0.009785
0.003914
0.015656
0.04501
0.033268
0.027397
0.048924
0.056751
0.033268
0.005871
0.017613
0.031311
0
36,946
G
A
G
C
T
G
G
A
A
G
C
A
C
C
T
G
G
A
G
G
A
T
G
G
G
G
C
A
A
G
G
A
C
G
G
A
G
A
C
A
G
C
A
G
A
G
G
A
A
C
T
G
A
G
A
G
C
A
C
T
T
G
C
T
A
T
0.019569
0.017613
0.046967
0.011742
0.023483
0.039139
0.015656
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0.046967
0.064579
0.04501
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0.023483
0.039139
0.062622
0.062622
0.043053
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0.011742
0.007828
0.015656
0.043053
0.035225
0.02544
0.052838
0.050881
0.041096
0.007828
0.017613
0.02544
0
36,947
C
G
T
G
G
C
A
C
T
G
A
G
G
A
C
A
C
C
A
A
A
G
A
G
G
A
C
A
G
T
C
T
C
T
G
C
C
C
C
A
A
G
G
A
T
G
C
T
T
G
G
C
C
A
C
C
A
G
C
C
A
G
C
C
C
G
0.02544
0.021526
0.048924
0.009785
0.033268
0.041096
0.011742
0.017613
0.048924
0.035225
0.060665
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0.007828
0.011742
0.037182
0.04501
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0.068493
0.080235
0.017613
0.003914
0.013699
0.009785
0.046967
0.035225
0.029354
0.031311
0.060665
0.046967
0.007828
0.007828
0.019569
0
36,948
C
T
T
C
C
A
G
T
C
A
G
G
T
C
A
G
T
G
A
C
T
G
G
A
G
A
G
C
T
C
C
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T
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G
A
A
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G
T
C
T
C
T
C
A
G
T
G
A
C
C
T
G
G
C
T
G
C
T
G
G
C
A
C
A
0.039139
0.019569
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0.019569
0.019569
0.039139
0.005871
0.027397
0.04501
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0.029354
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0.031311
0.033268
0.029354
0.043053
0.056751
0.007828
0.009785
0.035225
0
36,949
T
T
C
C
C
T
T
T
T
G
G
G
T
T
C
C
A
G
G
G
T
A
T
A
T
C
T
C
A
G
A
G
C
C
T
G
G
A
G
A
A
C
G
T
G
T
C
T
G
G
T
T
A
T
T
A
T
G
C
A
G
A
T
G
C
A
0.02544
0.02544
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0.007828
0.02544
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0.050881
0.052838
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0.027397
0.035225
0.037182
0.066536
0.062622
0.054795
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0.001957
0
0.011742
0.04501
0.033268
0.029354
0.039139
0.023483
0.046967
0.011742
0.015656
0.039139
0
36,950
G
C
A
C
A
A
G
G
G
G
G
C
A
A
A
A
T
C
C
G
A
G
T
C
T
G
C
T
G
A
G
T
C
G
C
T
G
A
G
G
C
A
G
T
G
G
G
C
T
C
A
G
G
A
G
C
T
G
G
A
G
G
A
G
A
T
0.043053
0.023483
0.037182
0.04501
0.041096
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0.011742
0.035225
0.035225
0.029354
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0.033268
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0.043053
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0.015656
0.007828
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0.031311
0.029354
0.031311
0.037182
0.041096
0.013699
0.021526
0.04501
0
36,951
T
G
T
G
C
A
A
G
A
C
T
C
A
C
T
G
G
A
C
T
T
G
C
A
C
A
A
G
G
G
G
G
C
A
A
A
A
T
C
C
G
A
G
T
C
T
G
C
T
G
A
G
T
C
G
C
T
G
A
G
G
C
A
G
T
A
0.04501
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0.041096
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0.015656
0.013699
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0.033268
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0.02544
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0.031311
0.052838
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0.039139
0.04501
0.043053
0.015656
0.009785
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0.037182
0.029354
0.031311
0.031311
0.039139
0.041096
0.013699
0.021526
0.04501
0
36,952
G
T
G
C
A
A
A
A
G
A
A
A
G
C
A
C
A
T
T
G
G
G
T
G
T
G
A
T
G
T
C
A
C
G
C
A
G
A
A
T
G
T
C
C
C
T
T
A
A
T
G
C
C
T
C
C
A
A
T
T
G
G
T
C
A
T
0.027397
0.023483
0.027397
0.031311
0.054795
0.023483
0.017613
0.02544
0.02544
0.04501
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0.017613
0.031311
0.041096
0.04501
0.050881
0.062622
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0.033268
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0.013699
0.02544
0.021526
0.029354
0.046967
0.048924
0.029354
0.017613
0.013699
0.041096
0
36,953
C
A
G
G
C
T
C
A
G
C
C
C
T
G
C
T
G
T
A
A
A
T
G
G
T
G
C
C
A
A
C
A
T
A
A
C
G
C
C
A
A
T
G
A
C
A
G
A
C
A
G
G
A
T
G
C
C
A
G
T
G
G
A
G
C
C
0.046967
0.017613
0.033268
0.039139
0.04501
0.019569
0.013699
0.019569
0.043053
0.050881
0.033268
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0.029354
0.048924
0.041096
0.041096
0.066536
0.050881
0.017613
0.001957
0.009785
0.009785
0.011742
0.035225
0.035225
0.029354
0.056751
0.037182
0.031311
0.009785
0.013699
0.04501
0
36,954
C
A
G
G
G
C
T
C
T
G
A
G
C
C
A
A
G
C
T
C
A
C
C
A
G
A
T
G
C
A
G
A
C
G
A
C
A
A
A
G
A
T
T
T
T
C
A
G
C
A
A
A
G
C
A
G
C
T
C
C
C
T
C
C
A
G
0.043053
0.021526
0.023483
0.02544
0.029354
0.023483
0.011742
0.021526
0.035225
0.060665
0.060665
0.003914
0.023483
0.021526
0.039139
0.029354
0.072407
0.046967
0.050881
0.007828
0.005871
0.013699
0.029354
0.052838
0.02544
0.027397
0.039139
0.050881
0.041096
0.007828
0.007828
0.046967
0
36,955
G
A
G
C
C
A
A
G
C
T
C
A
C
C
A
G
A
T
G
C
A
G
A
C
G
A
C
A
A
A
G
A
T
T
T
T
C
A
G
C
A
A
A
G
C
A
G
C
T
C
C
C
T
C
C
A
T
G
T
C
G
C
T
G
C
C
0.043053
0.019569
0.023483
0.02544
0.027397
0.02544
0.011742
0.021526
0.035225
0.062622
0.058708
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0.02544
0.035225
0.029354
0.072407
0.048924
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0.007828
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0.013699
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0.052838
0.02544
0.027397
0.041096
0.046967
0.041096
0.009785
0.007828
0.046967
0
36,956
T
A
G
T
A
A
A
C
A
A
A
T
T
G
C
G
G
G
C
A
C
G
A
G
C
C
C
A
A
G
C
C
C
G
C
A
A
C
T
T
G
G
A
C
C
A
A
A
G
C
G
G
C
A
C
C
A
A
T
G
T
A
G
C
A
T
0.013699
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0.033268
0.02544
0.043053
0.048924
0.009785
0.023483
0.027397
0.037182
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0.056751
0.050881
0.050881
0.064579
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0.017613
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0.013699
0.041096
0.02544
0.021526
0.046967
0.046967
0.037182
0.017613
0.009785
0.031311
0
36,957
T
T
A
C
A
G
A
A
A
C
T
C
A
C
C
T
C
G
T
T
C
C
A
G
C
T
T
C
C
T
C
T
T
C
C
C
T
C
A
C
T
C
T
C
A
C
A
C
C
A
A
G
G
C
A
G
G
G
T
C
C
T
C
T
T
A
0.023483
0.02544
0.02544
0.021526
0.064579
0.023483
0.003914
0.023483
0.054795
0.031311
0.056751
0.023483
0.037182
0.035225
0.021526
0.041096
0.066536
0.041096
0.04501
0.003914
0.013699
0.001957
0.019569
0.056751
0.035225
0.023483
0.019569
0.033268
0.04501
0.027397
0.015656
0.039139
0
36,958
G
C
A
G
G
A
G
G
G
C
A
G
A
C
A
G
A
G
C
T
G
G
G
G
C
C
T
C
G
G
A
C
C
T
G
C
C
C
A
A
T
A
C
T
T
G
T
G
A
G
G
A
G
C
T
G
C
A
T
C
C
A
G
G
A
A
0.007828
0.013699
0.031311
0.007828
0.031311
0.031311
0.005871
0.023483
0.041096
0.050881
0.080235
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0.015656
0.02544
0.027397
0.027397
0.080235
0.054795
0.076321
0.009785
0.003914
0.003914
0.009785
0.074364
0.021526
0.039139
0.037182
0.041096
0.07045
0.011742
0.003914
0.035225
0
36,959
G
G
C
A
C
G
G
A
G
C
C
T
T
C
T
T
A
T
G
T
T
A
T
C
C
T
C
A
A
G
C
T
C
A
C
T
T
T
T
C
A
A
C
C
G
A
G
G
A
A
A
C
T
C
T
T
T
C
A
G
A
A
A
C
C
T
0.04501
0.023483
0.050881
0.019569
0.031311
0.043053
0.009785
0.023483
0.041096
0.033268
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0.031311
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0.039139
0.043053
0.050881
0.056751
0.02544
0.019569
0.011742
0.005871
0.001957
0.04501
0.035225
0.023483
0.039139
0.039139
0.04501
0.019569
0.019569
0.037182
0
36,960
T
G
G
G
C
T
T
G
T
G
T
C
C
A
C
C
A
C
T
T
C
T
T
T
C
C
G
T
A
G
T
C
C
A
T
G
G
T
A
C
T
G
C
T
G
G
T
A
A
T
C
C
C
G
G
T
C
A
A
A
G
C
G
G
C
T
0.031311
0.019569
0.046967
0.019569
0.02544
0.041096
0.015656
0.027397
0.033268
0.039139
0.048924
0.009785
0.023483
0.033268
0.043053
0.041096
0.04501
0.058708
0.039139
0.021526
0.013699
0.007828
0.003914
0.050881
0.035225
0.029354
0.029354
0.04501
0.043053
0.019569
0.009785
0.048924
0
36,961
G
A
A
A
G
T
T
G
G
A
T
A
T
G
T
T
C
T
C
A
C
C
C
A
A
A
A
A
C
T
C
C
C
T
C
A
C
C
T
C
C
T
T
C
A
A
T
T
T
G
T
C
A
A
G
G
C
T
T
T
T
G
A
T
G
T
0.027397
0.017613
0.039139
0.023483
0.02544
0.043053
0.015656
0.02544
0.031311
0.043053
0.048924
0.005871
0.023483
0.037182
0.037182
0.043053
0.048924
0.062622
0.041096
0.021526
0.011742
0.009785
0.003914
0.054795
0.031311
0.029354
0.027397
0.04501
0.04501
0.019569
0.009785
0.050881
0
36,962
G
A
G
G
T
A
G
A
C
T
A
C
A
T
C
C
A
G
C
A
C
A
A
G
A
A
A
G
A
A
G
C
T
T
A
C
A
G
G
G
G
C
C
A
C
A
T
C
C
G
T
G
A
G
C
T
T
G
A
C
T
C
C
T
C
C
0.046967
0.021526
0.041096
0.02544
0.033268
0.02544
0.013699
0.023483
0.04501
0.052838
0.046967
0.015656
0.019569
0.029354
0.031311
0.033268
0.064579
0.041096
0.035225
0.013699
0.007828
0.007828
0.007828
0.056751
0.037182
0.023483
0.035225
0.041096
0.035225
0.019569
0.019569
0.048924
0
36,963
G
T
G
G
C
T
C
A
G
G
A
G
C
T
G
G
A
G
G
A
G
A
A
G
C
T
A
A
A
C
A
T
T
C
T
C
A
A
C
A
A
T
A
A
T
T
A
T
A
A
G
A
T
T
C
T
G
C
A
G
G
C
G
G
A
G
0.037182
0.017613
0.041096
0.023483
0.033268
0.023483
0.009785
0.02544
0.046967
0.060665
0.050881
0.009785
0.019569
0.021526
0.035225
0.035225
0.068493
0.041096
0.035225
0.011742
0.009785
0.015656
0.011742
0.062622
0.031311
0.023483
0.041096
0.043053
0.035225
0.017613
0.015656
0.04501
0
36,964
G
G
C
T
T
C
G
T
C
C
C
G
G
T
T
C
T
T
G
T
T
G
G
C
C
G
A
G
T
C
G
A
T
G
T
G
C
G
C
C
T
C
C
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G
G
T
C
C
T
T
C
A
G
G
T
C
C
A
T
C
T
C
C
A
C
0.009785
0.027397
0.033268
0.001957
0.017613
0.039139
0.003914
0.029354
0.033268
0.04501
0.060665
0.007828
0.021526
0.027397
0.017613
0.031311
0.072407
0.066536
0.064579
0.027397
0.019569
0.019569
0.009785
0.054795
0.039139
0.02544
0.033268
0.058708
0.056751
0.005871
0.007828
0.031311
0
36,965
G
G
A
G
G
G
T
G
A
T
G
G
A
G
T
C
G
G
C
A
C
T
C
T
G
G
T
T
G
G
T
G
T
T
G
G
C
T
T
C
T
T
C
C
A
G
G
A
A
G
A
A
T
T
T
C
G
G
G
G
T
G
A
C
A
C
0.019569
0.021526
0.031311
0.017613
0.02544
0.031311
0.007828
0.029354
0.037182
0.046967
0.058708
0.005871
0.015656
0.031311
0.029354
0.027397
0.068493
0.058708
0.064579
0.015656
0.011742
0.011742
0.013699
0.058708
0.037182
0.035225
0.035225
0.043053
0.060665
0.007828
0.003914
0.037182
0
36,966
A
T
C
T
T
T
C
C
T
C
T
G
T
C
C
C
C
G
C
C
T
G
C
A
G
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G
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C
C
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T
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G
T
A
G
C
C
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G
G
T
T
T
A
T
C
A
G
T
C
C
C
C
A
A
C
C
A
G
C
0.037182
0.023483
0.027397
0.019569
0.029354
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0.017613
0.033268
0.037182
0.031311
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0.02544
0.043053
0.046967
0.017613
0.017613
0.037182
0
36,967
C
T
G
T
C
C
A
G
C
C
T
T
C
C
T
G
C
C
A
T
C
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A
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G
C
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C
A
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A
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C
A
C
C
T
T
C
T
C
A
T
G
G
G
T
C
C
C
T
C
T
C
0.007828
0.007828
0.039139
0.005871
0.023483
0.029354
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0.039139
0.043053
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0.064579
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0.011742
0.066536
0.027397
0.02544
0.035225
0.054795
0.060665
0.011742
0.005871
0.035225
0
36,968
G
C
T
G
A
G
C
A
C
G
G
C
G
G
C
C
C
C
G
T
C
A
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A
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C
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C
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C
T
G
G
G
C
C
T
C
A
T
C
C
C
C
T
G
G
G
T
G
0.019569
0.011742
0.029354
0.009785
0.027397
0.027397
0.011742
0.013699
0.054795
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0.029354
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0.052838
0.058708
0.007828
0.003914
0.035225
0
36,969
A
G
C
C
C
C
C
T
G
G
C
T
C
G
G
C
C
T
T
C
T
C
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A
C
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A
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G
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T
C
C
C
A
T
C
G
C
C
T
G
G
G
C
C
A
G
A
G
T
0.009785
0.009785
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0.023483
0.084149
0.066536
0.011742
0.001957
0.015656
0
36,970
G
C
A
C
T
G
C
C
C
T
A
G
G
G
A
G
C
T
G
C
C
T
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A
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C
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C
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G
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C
T
C
C
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G
G
G
G
C
A
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G
G
G
C
T
G
T
G
G
G
G
A
T
G
A
C
A
G
A
C
A
0.011742
0.017613
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0.007828
0.027397
0.031311
0.011742
0.017613
0.050881
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0.072407
0
0.015656
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0.023483
0.027397
0.07045
0.056751
0.107632
0.013699
0.013699
0.011742
0.007828
0.066536
0.033268
0.037182
0.033268
0.048924
0.062622
0.007828
0
0.02544
0
36,971
C
G
G
G
G
G
A
A
G
G
G
G
G
C
A
G
G
A
G
G
T
C
G
T
C
G
G
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G
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C
G
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C
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C
T
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C
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C
C
C
T
G
A
G
C
A
G
T
G
C
C
C
T
G
G
A
C
T
T
T
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0.056751
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0.033268
0
36,972
A
G
C
T
A
C
T
C
G
G
G
A
G
G
C
T
A
A
G
G
C
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C
A
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A
A
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G
G
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G
G
C
G
G
A
G
G
T
T
G
T
G
G
T
G
A
G
C
C
G
C
0.050881
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0.017613
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0.027397
0.017613
0.029354
0.037182
0.037182
0.019569
0.019569
0.031311
0
36,973
G
T
T
G
A
G
C
C
G
C
A
C
C
C
A
C
T
T
G
C
C
C
C
A
G
C
C
G
C
C
T
G
C
G
G
C
G
C
G
G
C
C
G
C
C
C
G
C
C
C
C
C
G
C
C
G
G
C
G
G
C
G
C
T
G
T
0.001957
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0
0.007828
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0
0.013699
0
36,974
G
C
A
G
T
T
G
A
T
C
C
C
A
C
A
G
G
A
C
C
T
G
T
G
C
A
G
C
G
A
G
G
T
C
T
A
T
C
G
C
T
A
C
C
A
G
G
T
G
A
C
G
C
C
A
C
G
C
A
T
G
C
T
G
T
C
0.015656
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0.021526
0.056751
0.046967
0.04501
0.011742
0.011742
0.031311
0
36,975
C
C
A
C
T
C
C
A
G
C
C
G
G
A
G
T
T
T
G
A
G
C
A
T
G
A
G
G
T
C
C
T
T
G
G
G
G
C
C
C
T
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C
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G
T
G
C
C
A
C
A
G
G
C
A
G
C
T
G
G
A
G
G
C
0.009785
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0.072407
0.068493
0.013699
0.005871
0.027397
0
36,976
T
A
C
T
T
T
A
C
T
T
A
C
G
A
C
C
C
C
T
A
C
T
C
A
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A
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A
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A
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G
A
T
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T
G
T
G
G
C
C
G
G
G
G
C
A
C
C
C
A
C
A
G
G
A
0.005871
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0
0.011742
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0
36,977
T
G
A
C
A
A
G
G
G
G
G
A
G
A
T
G
G
G
C
A
G
C
C
C
C
G
G
C
G
C
C
C
C
G
T
G
C
C
A
G
A
A
G
C
G
C
T
T
C
T
T
C
G
C
C
T
T
C
T
C
A
G
T
G
G
T
0.021526
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0.027397
0.033268
0.052838
0.068493
0.033268
0.017613
0.011742
0.027397
0
36,978
G
G
G
G
G
T
C
C
T
C
A
G
A
G
T
C
A
C
A
G
C
A
C
C
G
T
T
G
G
C
A
G
C
C
G
C
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G
G
C
C
A
C
A
G
C
T
C
T
G
T
C
A
A
A
G
G
T
G
A
G
C
T
C
C
T
0.007828
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0.062622
0.019569
0.027397
0.027397
0.052838
0.064579
0.011742
0.009785
0.043053
0
36,979
G
C
T
C
C
T
G
C
T
C
T
T
T
C
T
C
C
T
G
A
T
G
T
G
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G
A
G
A
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C
C
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G
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G
G
A
G
C
T
C
A
C
C
T
T
T
G
A
C
A
G
A
G
C
T
G
T
G
G
G
0.005871
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0.035225
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0.007828
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0.037182
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0.058708
0.021526
0.031311
0.031311
0.050881
0.064579
0.011742
0.007828
0.037182
0
36,980
G
C
G
C
T
G
C
C
C
A
G
A
C
G
G
G
A
C
C
C
A
G
G
G
C
G
G
C
T
G
T
C
C
C
C
A
T
G
G
T
G
A
C
C
T
G
G
A
A
C
A
A
G
G
A
A
G
G
A
G
G
G
A
C
A
A
0.003914
0.013699
0.023483
0.005871
0.033268
0.033268
0.007828
0.027397
0.039139
0.035225
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0.017613
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0.015656
0.041096
0.076321
0.052838
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0.023483
0.003914
0.015656
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0.054795
0.019569
0.035225
0.039139
0.050881
0.060665
0.009785
0.007828
0.037182
0
36,981
G
C
C
C
C
C
A
G
A
T
G
C
C
A
C
C
C
T
G
G
G
C
A
A
C
G
T
G
T
C
G
G
C
G
G
G
C
C
C
A
A
G
C
C
C
G
G
C
A
G
G
G
C
T
G
G
C
C
G
T
C
A
G
T
G
T
0.011742
0.017613
0.015656
0.007828
0.023483
0.037182
0.02544
0.009785
0.031311
0.043053
0.056751
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0.023483
0.043053
0.009785
0.037182
0.080235
0.066536
0.07045
0.029354
0.021526
0.021526
0.009785
0.037182
0.029354
0.033268
0.041096
0.082192
0.033268
0.007828
0.001957
0.037182
0
36,982
C
C
T
C
C
T
G
C
A
A
C
T
C
C
C
G
C
A
G
T
G
A
C
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C
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C
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C
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C
T
G
G
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C
T
C
A
G
C
A
C
G
C
A
G
C
T
C
A
G
A
G
A
C
A
A
G
G
T
0.001957
0.005871
0.033268
0.001957
0.02544
0.035225
0.009785
0.017613
0.031311
0.058708
0.080235
0
0.007828
0.009785
0.015656
0.043053
0.097847
0.060665
0.105675
0.017613
0.005871
0.013699
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0.023483
0.021526
0.054795
0.076321
0.043053
0.017613
0.001957
0.02544
0
36,983
C
C
C
C
G
G
C
T
C
C
G
G
C
T
C
C
G
G
C
T
C
C
A
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C
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C
C
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C
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C
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C
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C
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T
G
G
C
T
T
C
A
G
C
A
G
C
T
A
C
C
A
A
G
A
0.023483
0.017613
0.02544
0.02544
0.033268
0.02544
0.011742
0.02544
0.039139
0.058708
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0.021526
0.035225
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0.037182
0
0.013699
0.011742
0.064579
0.035225
0.031311
0.013699
0.058708
0.058708
0.011742
0.007828
0.048924
0
36,984
T
G
C
C
T
G
C
T
C
C
T
A
C
G
G
G
A
C
T
G
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G
T
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A
G
G
C
T
G
G
T
A
A
A
T
A
A
A
T
T
0.07045
0.011742
0.041096
0.035225
0.035225
0.017613
0.003914
0.023483
0.041096
0.033268
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0.027397
0.035225
0.04501
0.058708
0.013699
0.021526
0.019569
0
36,985
A
G
C
T
C
T
A
C
T
G
G
G
A
G
A
G
G
A
G
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C
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C
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G
G
A
T
G
T
T
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G
G
G
G
T
T
G
T
C
T
C
T
0.011742
0.039139
0.009785
0.019569
0.058708
0.027397
0.011742
0.013699
0.064579
0.041096
0.050881
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0.02544
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0.02544
0.013699
0.02544
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0.015656
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0.001957
0
36,986
C
A
T
C
A
G
A
G
C
C
A
C
C
C
A
A
C
A
G
G
A
C
A
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A
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A
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C
T
T
G
T
A
T
T
C
A
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A
G
A
A
C
A
T
C
C
C
C
A
G
A
T
C
A
T
C
T
T
G
0.017613
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0.062622
0.019569
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0.02544
0
36,987
C
G
C
A
C
A
C
A
G
T
C
C
T
T
T
T
C
C
T
T
T
C
A
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G
A
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G
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A
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C
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C
T
C
A
T
C
T
C
A
A
T
G
C
T
G
C
A
C
C
C
A
A
0.021526
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0.027397
0.058708
0.015656
0.005871
0.031311
0
36,988
C
C
C
C
A
C
C
A
C
G
C
C
A
G
G
C
T
C
C
T
G
A
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C
C
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C
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A
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G
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C
C
C
C
T
G
G
A
A
C
T
A
G
T
A
T
G
G
A
G
C
0
0.007828
0.021526
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0.02544
0.039139
0.009785
0.023483
0.029354
0.037182
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0.064579
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0.066536
0.121331
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0.07045
0.019569
0.011742
0.046967
0.054795
0.066536
0.011742
0.001957
0.017613
0
36,989
G
G
T
C
T
C
T
T
C
T
C
A
G
G
A
C
T
C
C
A
A
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G
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G
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C
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C
G
C
C
G
G
G
T
C
A
G
T
T
C
T
G
C
C
T
G
A
0.023483
0.007828
0.02544
0.001957
0.02544
0.037182
0
0.013699
0.052838
0.052838
0.084149
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0.011742
0.011742
0.015656
0.027397
0.09002
0.054795
0.09589
0.019569
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0.009785
0.009785
0.078278
0.019569
0.035225
0.029354
0.064579
0.054795
0.005871
0.001957
0.035225
0
36,990
T
C
C
C
A
C
C
T
T
T
G
A
G
A
C
C
T
G
C
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G
G
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G
A
C
C
T
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G
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C
A
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C
A
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A
T
A
A
C
C
T
C
T
C
A
G
A
G
C
T
C
A
G
T
C
0.027397
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0.029354
0.039139
0.062622
0.039139
0.009785
0.009785
0.041096
0
36,991
G
T
G
G
C
A
T
T
C
T
G
G
A
G
G
G
G
G
A
G
C
T
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C
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C
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C
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C
T
T
G
G
A
A
G
A
G
T
G
A
G
C
G
G
G
T
C
T
0.015656
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0.009785
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0.027397
0.017613
0.019569
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0.021526
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0.023483
0.02544
0.033268
0.076321
0.058708
0.007828
0.015656
0.015656
0
36,992
G
C
C
T
G
G
C
A
C
T
G
T
C
A
T
C
T
T
T
C
C
A
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C
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G
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C
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C
T
G
C
T
G
T
A
T
C
C
A
T
C
T
C
C
T
C
T
C
0.039139
0.027397
0.031311
0.013699
0.037182
0.041096
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0.029354
0.033268
0.054795
0.064579
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0.019569
0.013699
0.033268
0.039139
0.088063
0.062622
0.046967
0.001957
0.001957
0.005871
0.013699
0.048924
0.027397
0.02544
0.035225
0.043053
0.046967
0.017613
0.011742
0.039139
0
36,993
A
G
T
G
T
G
C
A
C
C
G
A
C
C
G
C
G
C
C
T
T
C
G
C
C
G
T
G
T
A
C
G
C
C
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C
A
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A
A
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T
T
C
C
T
G
A
T
G
G
C
G
C
T
C
G
G
G
C
T
C
T
T
0
0.005871
0.015656
0.001957
0.017613
0.019569
0.037182
0.009785
0.007828
0.050881
0.041096
0.001957
0.011742
0.015656
0.007828
0.033268
0.068493
0.037182
0.060665
0.088063
0.027397
0.133072
0.001957
0.023483
0.015656
0.037182
0.052838
0.11546
0.035225
0.007828
0
0.017613
0
36,994
C
A
A
G
T
C
C
A
G
C
A
G
G
C
G
C
C
G
G
C
G
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C
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C
T
G
G
G
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G
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T
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C
C
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C
G
C
G
C
A
G
C
T
G
C
A
G
C
C
C
C
G
C
A
C
A
0
0.005871
0.017613
0
0.019569
0.017613
0.035225
0.009785
0.003914
0.056751
0.037182
0
0.009785
0.013699
0.005871
0.031311
0.066536
0.033268
0.062622
0.099804
0.033268
0.133072
0.001957
0.021526
0.017613
0.039139
0.052838
0.117417
0.039139
0.005871
0
0.011742
0
36,995
C
G
C
C
C
T
A
C
C
C
C
T
C
G
G
G
C
C
G
C
C
T
G
A
C
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C
C
C
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C
C
T
G
C
C
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G
A
C
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T
G
A
G
G
C
C
C
T
G
G
G
C
G
C
C
C
C
C
G
C
0.003914
0.007828
0.003914
0.003914
0.007828
0.029354
0.021526
0.007828
0.013699
0.039139
0.056751
0
0.005871
0.009785
0.001957
0.019569
0.064579
0.048924
0.164384
0.086106
0.015656
0.084149
0.011742
0.037182
0.013699
0.031311
0.021526
0.121331
0.041096
0.007828
0
0.017613
0
36,996
G
G
C
C
A
T
G
G
C
T
C
A
C
C
T
C
T
G
T
G
T
C
C
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C
A
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C
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G
G
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C
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C
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C
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G
C
C
C
A
G
C
A
A
A
A
A
C
A
C
T
C
A
G
A
C
0.031311
0.023483
0.039139
0.02544
0.041096
0.017613
0.005871
0.019569
0.037182
0.046967
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0.015656
0.015656
0.04501
0.037182
0.027397
0.07045
0.066536
0.046967
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0.005871
0
0.013699
0.039139
0.043053
0.027397
0.043053
0.058708
0.050881
0.005871
0.007828
0.031311
0
36,997
T
T
A
T
C
C
T
C
T
C
T
C
C
A
T
C
T
C
C
A
A
C
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A
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A
A
G
G
C
C
C
T
C
A
T
C
G
T
G
T
T
C
G
G
T
0.019569
0.021526
0.029354
0.009785
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0.035225
0.017613
0.027397
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0.064579
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0.007828
0.062622
0.023483
0.031311
0.039139
0.043053
0.052838
0.013699
0.007828
0.033268
0
36,998
A
G
C
C
T
C
C
T
C
A
C
C
T
G
C
C
C
C
T
C
C
C
G
C
T
C
C
C
T
G
C
C
C
G
G
C
A
G
G
C
C
G
C
T
G
T
G
C
C
C
C
C
A
T
G
A
A
G
A
G
C
A
T
C
T
T
0.013699
0.011742
0.023483
0.007828
0.021526
0.031311
0.017613
0.015656
0.037182
0.052838
0.058708
0.007828
0.017613
0.029354
0.015656
0.041096
0.072407
0.066536
0.09002
0.021526
0.007828
0.027397
0.007828
0.058708
0.02544
0.027397
0.037182
0.062622
0.052838
0.005871
0.001957
0.031311
0
36,999
G
G
C
C
A
G
C
C
T
G
G
A
C
C
C
A
G
T
C
A
T
G
G
T
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C
T
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C
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G
G
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C
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T
G
G
G
C
C
C
C
T
G
G
G
T
C
T
G
G
C
T
A
G
G
0.017613
0.013699
0.029354
0.009785
0.037182
0.037182
0.011742
0.005871
0.033268
0.054795
0.056751
0.001957
0.013699
0.031311
0.019569
0.037182
0.086106
0.066536
0.097847
0.023483
0.009785
0.015656
0.007828
0.027397
0.029354
0.031311
0.050881
0.07045
0.039139
0.009785
0.003914
0.019569
0
37,000
C
A
T
C
T
T
C
T
A
C
T
G
T
G
A
C
T
T
C
T
T
C
T
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C
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T
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A
C
C
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G
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G
T
C
C
T
G
G
G
A
T
G
A
C
A
G
C
A
A
T
G
G
0.035225
0.021526
0.037182
0.035225
0.046967
0.027397
0.001957
0.048924
0.066536
0.02544
0.02544
0.033268
0.033268
0.043053
0.037182
0.02544
0.064579
0.046967
0.009785
0.005871
0.001957
0.001957
0.035225
0.029354
0.033268
0.037182
0.033268
0.02544
0.02544
0.041096
0.023483
0.041096
0
37,001
T
A
C
C
T
G
A
A
A
G
T
G
A
A
A
C
G
T
C
T
G
A
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C
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C
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C
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A
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A
G
T
G
A
A
C
T
T
G
C
C
A
A
G
G
A
G
T
G
T
0.015656
0.015656
0.04501
0.005871
0.02544
0.027397
0.017613
0.031311
0.035225
0.04501
0.072407
0.007828
0.017613
0.019569
0.019569
0.048924
0.076321
0.04501
0.072407
0.005871
0.005871
0.009785
0.009785
0.050881
0.037182
0.02544
0.062622
0.035225
0.060665
0.011742
0.009785
0.031311
0
37,002
C
T
G
G
T
T
C
C
C
A
C
C
C
A
G
G
A
G
C
T
C
C
C
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G
G
A
G
G
A
A
C
T
G
C
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G
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G
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C
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C
C
A
A
C
T
G
G
G
G
T
G
A
G
T
G
T
G
G
A
G
G
0.009785
0.013699
0.02544
0.003914
0.027397
0.037182
0.009785
0.023483
0.031311
0.048924
0.080235
0.001957
0.007828
0.017613
0.013699
0.050881
0.074364
0.052838
0.076321
0.023483
0.007828
0.021526
0.009785
0.074364
0.029354
0.02544
0.046967
0.048924
0.07045
0.007828
0
0.027397
0
37,003
G
A
G
G
A
A
G
C
A
C
A
T
T
T
C
T
G
C
G
T
G
G
T
A
C
T
G
A
G
G
C
T
T
G
A
A
A
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C
A
C
C
T
G
G
G
A
G
A
G
G
A
G
C
A
G
G
G
G
G
C
A
G
G
C
0.017613
0.015656
0.029354
0.021526
0.031311
0.027397
0.009785
0.023483
0.041096
0.04501
0.068493
0.007828
0.021526
0.017613
0.023483
0.039139
0.072407
0.04501
0.07045
0.013699
0.007828
0.015656
0.015656
0.060665
0.027397
0.019569
0.04501
0.050881
0.048924
0.019569
0.015656
0.031311
0
37,004
G
A
T
C
A
C
C
T
G
G
T
T
T
G
T
A
T
C
C
T
G
G
A
C
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C
C
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C
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C
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C
G
A
A
G
C
T
G
G
C
C
G
A
A
T
T
C
C
T
G
T
T
0.013699
0.009785
0.02544
0.015656
0.027397
0.031311
0.007828
0.017613
0.039139
0.041096
0.07045
0.005871
0.029354
0.031311
0.017613
0.033268
0.076321
0.050881
0.086106
0.015656
0.007828
0.019569
0.007828
0.060665
0.029354
0.021526
0.046967
0.04501
0.060665
0.017613
0.003914
0.033268
0
37,005
C
A
T
T
G
G
A
G
A
A
C
C
A
T
C
T
G
C
C
C
C
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C
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C
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C
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T
C
T
C
C
T
C
A
G
C
C
C
C
C
C
A
C
G
T
C
T
0.027397
0.019569
0.023483
0.017613
0.039139
0.031311
0.007828
0.029354
0.033268
0.027397
0.062622
0.013699
0.021526
0.027397
0.02544
0.041096
0.07045
0.062622
0.074364
0.013699
0.003914
0.013699
0.007828
0.050881
0.023483
0.023483
0.029354
0.058708
0.048924
0.023483
0.013699
0.033268
0
37,006
G
A
A
A
A
C
A
G
T
G
A
G
G
G
C
C
C
A
G
C
A
G
G
C
C
T
C
T
C
T
C
C
T
G
G
C
C
C
T
G
G
G
C
C
C
T
C
C
C
C
T
C
C
C
A
G
C
C
C
A
G
G
T
A
T
C
0.037182
0.019569
0.023483
0.015656
0.029354
0.027397
0.007828
0.027397
0.039139
0.033268
0.064579
0.011742
0.015656
0.031311
0.019569
0.029354
0.068493
0.058708
0.084149
0.013699
0.005871
0.011742
0.009785
0.064579
0.02544
0.029354
0.027397
0.052838
0.056751
0.013699
0.011742
0.033268
0
37,007
T
C
A
A
G
T
G
C
T
C
A
G
T
A
G
C
C
C
C
T
T
T
G
G
C
C
A
G
T
G
C
G
C
C
C
C
A
C
C
A
C
A
T
G
G
G
A
C
A
G
C
G
C
A
G
G
T
C
C
A
G
T
G
G
C
T
0.052838
0.02544
0.027397
0.021526
0.035225
0.027397
0.007828
0.02544
0.029354
0.041096
0.050881
0.005871
0.021526
0.04501
0.037182
0.035225
0.066536
0.054795
0.048924
0.007828
0.005871
0.017613
0.011742
0.041096
0.033268
0.019569
0.046967
0.054795
0.033268
0.015656
0.005871
0.046967
0
37,008
C
T
G
G
T
T
T
C
G
G
A
A
G
A
C
G
C
C
C
C
T
C
T
T
C
C
A
G
G
A
G
A
C
A
G
G
T
G
A
G
T
G
G
T
G
C
T
T
T
A
C
A
A
C
T
T
C
C
A
T
G
G
T
G
A
T
0.07045
0.019569
0.039139
0.02544
0.035225
0.031311
0.013699
0.031311
0.04501
0.041096
0.043053
0.015656
0.011742
0.023483
0.02544
0.050881
0.058708
0.050881
0.037182
0.007828
0.009785
0.007828
0.019569
0.043053
0.04501
0.023483
0.04501
0.027397
0.043053
0.017613
0.013699
0.027397
0
37,009
A
C
C
C
T
C
A
C
C
T
G
A
G
A
A
T
C
T
C
C
C
C
C
A
G
C
A
T
G
A
T
G
T
G
C
A
G
T
A
A
T
A
T
A
T
A
A
T
A
T
T
T
A
G
G
C
A
G
A
T
T
A
T
T
C
C
0.017613
0.013699
0.027397
0.019569
0.02544
0.027397
0.007828
0.021526
0.052838
0.035225
0.09002
0.023483
0.013699
0.013699
0.019569
0.035225
0.068493
0.043053
0.066536
0.001957
0.011742
0.009785
0.013699
0.088063
0.027397
0.021526
0.037182
0.054795
0.054795
0.011742
0.013699
0.031311
0