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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
T
T
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G
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G
T
G
C
G
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G
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G
G
G
A
T
G
T
A
C
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A
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C
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C
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1
8,895
A
C
A
T
C
A
A
A
T
G
G
G
C
C
T
G
C
A
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A
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T
C
C
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T
C
A
C
T
C
C
G
A
T
A
C
C
A
G
A
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C
C
A
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T
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1
8,896
C
C
C
A
G
A
G
A
A
A
G
T
G
A
C
A
T
G
G
A
A
C
A
C
T
C
T
C
C
A
A
G
T
G
C
A
A
C
T
G
A
A
G
A
C
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G
C
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G
C
C
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C
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1
8,897
A
G
G
T
A
G
G
C
A
C
A
T
C
T
C
A
T
A
C
A
T
C
T
T
T
C
T
G
C
G
C
T
T
G
C
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T
G
T
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C
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C
A
T
G
G
T
T
C
T
C
T
G
C
A
T
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C
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C
A
C
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1
8,898
A
T
A
G
T
C
C
A
G
C
A
G
C
C
T
T
T
T
G
G
G
A
G
A
C
G
T
G
G
T
C
G
T
C
C
G
C
T
C
A
G
A
C
T
G
A
G
A
T
A
A
A
C
A
C
T
T
T
T
T
G
C
T
G
A
C
0.054795
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1
8,899
A
G
T
T
G
T
T
C
T
T
C
T
T
C
C
T
T
C
G
A
A
G
A
G
A
A
G
G
G
A
T
G
C
G
C
C
A
G
T
A
T
G
G
A
G
A
G
T
G
C
C
T
G
C
A
T
T
C
C
T
G
C
C
C
A
T
0.093933
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1
8,900
C
A
T
T
G
A
G
A
G
G
T
A
C
A
T
A
G
C
A
A
T
C
T
G
T
C
A
C
C
C
C
A
T
C
A
A
A
G
C
C
C
A
G
T
T
T
C
T
C
T
G
C
A
C
A
T
T
T
T
C
C
A
G
A
G
C
0.035225
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1
8,901
G
T
G
A
G
C
A
G
A
T
T
A
T
T
A
G
G
A
G
G
A
G
A
A
C
A
A
G
A
A
A
G
C
G
C
C
T
T
A
A
C
C
C
A
G
A
G
G
C
A
C
T
T
C
A
G
G
C
T
G
A
G
C
A
G
T
0.076321
0.035225
0.04501
0.04501
0.031311
0.017613
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0.013699
0.046967
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0.035225
0.015656
0.052838
0.037182
1
8,902
A
A
A
G
A
A
T
G
C
A
A
A
T
G
G
C
G
G
A
T
A
T
G
T
A
T
G
C
A
A
C
G
C
G
T
G
T
G
G
C
C
T
C
T
A
C
C
A
G
A
A
G
C
T
T
C
A
C
T
C
G
G
T
A
A
T
0.068493
0.035225
0.039139
0.031311
0.043053
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0.031311
0.019569
0.013699
0.037182
0.04501
1
8,903
T
C
T
C
T
G
G
C
G
A
A
A
G
A
A
T
G
C
A
A
A
T
G
G
C
G
G
A
T
A
T
G
T
A
T
G
C
A
A
C
G
C
G
T
G
T
G
G
C
C
T
C
T
A
C
C
A
G
A
A
G
C
T
T
C
G
0.068493
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0.048924
1
8,904
C
G
T
T
G
C
A
T
A
C
A
T
A
T
C
C
G
C
C
A
T
T
T
G
C
A
T
T
C
T
T
T
C
G
C
C
A
G
A
G
A
G
A
G
G
T
C
T
T
T
G
T
G
G
T
C
A
G
G
C
A
A
T
T
G
T
0.064579
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0.031311
0.021526
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0.048924
1
8,905
T
G
C
A
T
T
C
T
T
T
C
G
C
C
A
G
A
G
A
G
A
G
G
T
C
T
T
T
G
T
G
G
T
C
A
G
G
C
A
A
T
T
G
G
C
A
C
A
A
A
A
A
A
C
A
C
C
G
G
A
G
C
C
T
C
G
0.064579
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0.013699
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0.046967
1
8,906
A
G
A
G
A
G
A
G
G
T
C
T
T
T
G
T
G
G
T
C
A
G
G
C
A
A
T
T
G
G
C
A
C
A
A
A
A
A
A
C
A
C
C
G
G
A
G
C
C
T
C
T
A
C
G
C
C
T
C
T
G
A
A
A
C
T
0.07045
0.037182
0.035225
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0.050881
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0.033268
0.021526
0.033268
0.031311
0.021526
0.013699
0.035225
0.046967
1
8,907
T
T
A
T
A
T
A
A
T
A
T
G
G
A
A
C
C
T
T
G
G
T
C
C
A
G
G
T
G
T
T
G
C
G
A
T
G
A
T
G
T
C
A
C
T
G
T
A
C
G
G
T
T
C
T
T
C
C
T
G
T
G
T
C
A
T
0.091977
0.041096
0.048924
0.046967
0.054795
0.017613
0.005871
0.033268
0.037182
0.046967
0.023483
0.037182
0.027397
0.02544
0.050881
0.02544
0.043053
0.021526
0.021526
0.003914
0.007828
0.005871
0.029354
0.019569
0.048924
0.017613
0.027397
0.005871
0.02544
0.029354
0.037182
0.041096
1
8,908
G
A
C
A
G
G
A
G
G
A
G
T
A
G
A
A
A
A
A
C
T
G
T
T
T
T
C
T
T
T
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C
C
T
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C
T
C
A
G
C
C
T
T
T
G
T
G
G
A
A
T
A
A
C
A
G
A
C
T
A
C
T
G
A
G
0.113503
0.027397
0.050881
0.056751
0.043053
0.011742
0
0.037182
0.052838
0.021526
0.02544
0.043053
0.039139
0.037182
0.043053
0.023483
0.037182
0.029354
0.007828
0.001957
0
0.001957
0.023483
0.02544
0.046967
0.011742
0.02544
0.017613
0.027397
0.029354
0.04501
0.043053
1
8,909
T
T
T
A
T
G
C
T
G
G
A
A
T
A
A
C
C
A
T
C
A
T
T
C
C
C
A
C
A
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A
C
C
T
A
A
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A
T
T
C
C
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C
C
A
T
C
A
T
T
T
C
C
T
T
C
T
C
C
A
A
A
A
T
G
0.082192
0.046967
0.031311
0.078278
0.041096
0.019569
0.003914
0.035225
0.046967
0.027397
0.021526
0.052838
0.037182
0.043053
0.035225
0.023483
0.029354
0.023483
0.001957
0.001957
0.005871
0
0.043053
0.02544
0.048924
0.011742
0.019569
0.003914
0.023483
0.017613
0.07045
0.046967
1
8,910
C
C
T
C
T
T
T
T
A
C
T
G
A
G
A
A
C
A
A
A
A
T
G
T
G
C
G
T
A
G
A
A
C
A
T
T
G
T
T
C
T
G
G
C
T
G
G
C
T
A
T
G
A
A
A
A
C
A
G
A
A
G
A
A
A
T
0.146771
0.043053
0.037182
0.066536
0.048924
0.011742
0.003914
0.023483
0.054795
0.023483
0.019569
0.043053
0.023483
0.039139
0.04501
0.015656
0.019569
0.02544
0.019569
0.001957
0.003914
0.005871
0.029354
0.035225
0.039139
0.007828
0.011742
0.021526
0.013699
0.021526
0.064579
0.033268
1
8,911
G
C
C
C
T
A
C
G
A
C
A
A
C
A
T
C
A
T
C
A
C
A
G
A
C
G
C
C
G
T
G
C
T
C
A
G
C
C
T
T
G
A
C
G
A
G
G
A
C
A
C
G
G
T
G
C
T
T
T
C
A
A
C
A
A
C
0.041096
0.037182
0.033268
0.033268
0.043053
0.027397
0.015656
0.021526
0.037182
0.037182
0.054795
0.009785
0.021526
0.041096
0.039139
0.033268
0.054795
0.021526
0.033268
0.013699
0.009785
0.011742
0.023483
0.039139
0.043053
0.017613
0.054795
0.033268
0.029354
0.019569
0.021526
0.046967
1
8,912
A
C
T
C
C
C
A
T
C
C
A
T
T
G
C
T
G
A
G
C
A
T
C
A
C
A
G
G
G
A
C
G
C
A
G
G
C
A
G
C
C
T
G
A
G
C
A
A
A
A
A
A
G
G
G
G
A
C
T
T
C
G
T
G
A
T
0.058708
0.019569
0.046967
0.054795
0.029354
0.015656
0.013699
0.029354
0.039139
0.035225
0.041096
0.031311
0.033268
0.041096
0.039139
0.023483
0.050881
0.029354
0.023483
0.003914
0.007828
0.005871
0.023483
0.023483
0.050881
0.027397
0.037182
0.027397
0.031311
0.017613
0.031311
0.056751
1
8,913
T
T
C
A
C
G
A
A
G
T
C
C
C
C
T
T
T
T
T
T
G
C
T
C
A
G
G
C
T
G
C
C
T
G
C
G
T
C
C
C
T
G
T
G
A
T
G
C
T
C
A
G
C
A
A
T
G
G
A
T
G
G
G
A
G
C
0.058708
0.019569
0.046967
0.054795
0.029354
0.015656
0.013699
0.029354
0.039139
0.035225
0.041096
0.031311
0.033268
0.039139
0.039139
0.023483
0.050881
0.029354
0.023483
0.003914
0.007828
0.005871
0.023483
0.023483
0.050881
0.027397
0.037182
0.027397
0.031311
0.019569
0.031311
0.056751
1
8,914
C
C
C
T
A
T
T
C
T
G
G
G
A
A
G
G
C
T
C
C
A
G
G
G
C
C
T
C
T
T
A
C
C
T
G
C
A
A
A
G
C
C
T
C
C
A
G
G
A
A
T
C
T
G
A
A
G
G
A
C
C
C
A
A
G
A
0.068493
0.021526
0.04501
0.050881
0.023483
0.035225
0.003914
0.017613
0.048924
0.027397
0.052838
0.019569
0.027397
0.035225
0.031311
0.029354
0.039139
0.04501
0.035225
0.005871
0.011742
0.009785
0.019569
0.043053
0.050881
0.015656
0.033268
0.02544
0.043053
0.013699
0.037182
0.033268
1
8,915
C
A
G
G
G
C
C
T
C
T
T
A
C
C
T
G
C
A
A
A
G
C
C
T
C
C
A
G
G
A
A
T
C
T
G
A
A
G
G
A
C
C
C
A
A
G
C
C
T
G
C
G
A
C
C
A
C
G
A
G
G
A
A
C
C
A
0.066536
0.021526
0.04501
0.048924
0.023483
0.035225
0.003914
0.019569
0.04501
0.029354
0.050881
0.019569
0.02544
0.043053
0.029354
0.029354
0.039139
0.04501
0.035225
0.005871
0.011742
0.009785
0.017613
0.04501
0.048924
0.015656
0.035225
0.023483
0.043053
0.015656
0.037182
0.035225
1
8,916
A
G
G
G
C
C
T
C
T
T
A
C
C
T
G
C
A
A
A
G
C
C
T
C
C
A
G
G
A
A
T
C
T
G
A
A
G
G
A
C
C
C
A
A
G
C
C
T
G
C
G
A
C
C
A
C
G
A
G
G
A
A
C
C
A
C
0.066536
0.021526
0.04501
0.048924
0.023483
0.035225
0.003914
0.019569
0.04501
0.029354
0.050881
0.019569
0.02544
0.043053
0.029354
0.029354
0.039139
0.04501
0.035225
0.005871
0.011742
0.009785
0.015656
0.04501
0.048924
0.015656
0.035225
0.023483
0.043053
0.015656
0.037182
0.037182
1
8,917
A
A
G
C
C
T
C
C
A
G
G
A
A
T
C
T
G
A
A
G
G
A
C
C
C
A
A
G
C
C
T
G
C
G
A
C
C
A
C
G
A
G
G
A
A
C
C
A
G
A
C
A
G
A
A
A
G
T
G
G
C
A
T
T
G
A
0.064579
0.021526
0.043053
0.050881
0.02544
0.033268
0.003914
0.019569
0.041096
0.029354
0.050881
0.019569
0.029354
0.04501
0.033268
0.029354
0.037182
0.04501
0.033268
0.005871
0.011742
0.009785
0.015656
0.04501
0.046967
0.015656
0.035225
0.023483
0.04501
0.015656
0.035225
0.039139
1
8,918
A
A
G
C
C
T
C
C
A
G
G
A
A
T
C
T
G
A
A
G
G
A
C
C
C
A
A
G
C
C
T
G
C
G
A
C
C
A
C
G
A
G
G
A
A
C
C
A
G
A
C
A
G
A
A
A
G
T
G
G
C
A
T
T
G
T
0.064579
0.021526
0.043053
0.050881
0.02544
0.033268
0.003914
0.019569
0.041096
0.029354
0.050881
0.019569
0.029354
0.04501
0.033268
0.029354
0.037182
0.04501
0.033268
0.005871
0.011742
0.009785
0.015656
0.04501
0.046967
0.015656
0.035225
0.023483
0.04501
0.015656
0.035225
0.039139
1
8,919
C
C
T
C
C
A
G
G
A
A
T
C
T
G
A
A
G
G
A
C
C
C
A
A
G
C
C
T
G
C
G
A
C
C
A
C
G
A
G
G
A
A
C
C
A
G
A
C
A
G
A
A
A
G
T
G
G
C
A
T
T
G
T
G
C
T
0.066536
0.021526
0.04501
0.048924
0.02544
0.033268
0.003914
0.019569
0.041096
0.031311
0.050881
0.019569
0.027397
0.04501
0.033268
0.029354
0.037182
0.04501
0.033268
0.005871
0.011742
0.009785
0.015656
0.04501
0.046967
0.015656
0.035225
0.023483
0.043053
0.015656
0.035225
0.039139
1
8,920
A
A
T
G
C
T
G
C
A
C
A
A
T
G
C
C
A
C
T
T
T
C
T
G
T
C
T
G
G
T
T
C
C
T
C
G
T
G
G
T
C
G
C
A
G
G
C
T
T
G
G
G
T
C
C
T
T
C
A
G
A
T
T
C
C
G
0.066536
0.021526
0.04501
0.050881
0.02544
0.031311
0.003914
0.019569
0.041096
0.031311
0.050881
0.019569
0.027397
0.043053
0.035225
0.027397
0.037182
0.041096
0.033268
0.005871
0.011742
0.009785
0.017613
0.04501
0.046967
0.015656
0.037182
0.023483
0.043053
0.015656
0.037182
0.039139
1
8,921
T
A
G
G
T
A
T
G
A
T
T
A
T
C
G
G
G
A
A
A
T
G
C
T
G
C
A
C
A
A
T
G
C
C
A
C
T
T
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C
T
G
T
C
T
G
G
T
T
C
C
T
C
G
T
G
G
T
C
G
C
A
G
G
C
A
0.064579
0.021526
0.046967
0.046967
0.023483
0.031311
0.003914
0.019569
0.037182
0.033268
0.054795
0.019569
0.029354
0.041096
0.039139
0.027397
0.039139
0.041096
0.035225
0.005871
0.011742
0.009785
0.015656
0.04501
0.04501
0.015656
0.043053
0.023483
0.046967
0.013699
0.029354
0.039139
1
8,922
C
T
C
C
C
C
G
T
T
A
T
G
G
A
C
G
T
G
A
T
A
T
A
A
G
G
C
A
T
T
C
C
T
G
G
T
G
T
C
T
G
A
T
C
C
T
A
T
C
C
C
T
G
T
C
A
G
G
T
A
C
C
T
C
T
A
0.035225
0.023483
0.04501
0.009785
0.033268
0.029354
0.015656
0.031311
0.031311
0.02544
0.060665
0.021526
0.029354
0.029354
0.037182
0.033268
0.050881
0.046967
0.056751
0.019569
0.011742
0.007828
0.007828
0.04501
0.033268
0.033268
0.02544
0.043053
0.054795
0.019569
0.009785
0.043053
1
8,923
C
T
C
C
C
C
G
T
T
A
T
G
G
A
C
G
T
G
A
T
A
T
A
A
G
G
C
A
T
T
C
C
T
G
G
T
G
T
C
T
G
A
T
C
C
T
A
T
C
C
C
T
G
T
C
A
G
G
T
A
C
C
T
C
T
C
0.035225
0.023483
0.04501
0.009785
0.033268
0.029354
0.015656
0.031311
0.031311
0.02544
0.060665
0.021526
0.029354
0.029354
0.037182
0.033268
0.050881
0.046967
0.056751
0.019569
0.011742
0.007828
0.007828
0.04501
0.033268
0.033268
0.02544
0.043053
0.054795
0.019569
0.009785
0.043053
1
8,924
T
G
T
C
T
G
A
T
C
C
T
A
T
C
C
C
T
G
T
C
A
G
G
T
A
C
C
T
C
T
T
C
C
C
C
T
T
G
A
A
T
A
C
C
A
G
C
A
T
G
T
A
C
T
T
C
C
T
G
A
G
A
G
G
A
A
0.039139
0.023483
0.041096
0.023483
0.037182
0.031311
0.015656
0.027397
0.029354
0.021526
0.054795
0.021526
0.031311
0.033268
0.039139
0.035225
0.04501
0.048924
0.050881
0.019569
0.011742
0.007828
0.009785
0.039139
0.033268
0.031311
0.02544
0.039139
0.052838
0.021526
0.017613
0.041096
1
8,925
G
T
C
T
G
A
T
C
C
T
A
T
C
C
C
T
G
T
C
A
G
G
T
A
C
C
T
C
T
T
C
C
C
C
T
T
G
A
A
T
A
C
C
A
G
C
A
T
G
T
A
C
T
T
C
C
T
G
A
G
A
G
G
A
G
T
0.039139
0.023483
0.043053
0.023483
0.037182
0.031311
0.015656
0.027397
0.029354
0.021526
0.054795
0.021526
0.031311
0.033268
0.039139
0.035225
0.04501
0.048924
0.050881
0.019569
0.011742
0.007828
0.009785
0.037182
0.033268
0.031311
0.02544
0.039139
0.052838
0.021526
0.017613
0.041096
1
8,926
C
A
A
C
A
C
C
A
T
C
C
C
T
C
C
T
C
T
C
A
G
G
A
A
G
T
A
C
A
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C
T
G
G
T
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T
T
C
A
A
G
G
G
G
A
A
G
A
G
G
T
A
C
C
T
G
A
C
A
G
G
G
A
G
0.039139
0.023483
0.043053
0.023483
0.037182
0.031311
0.015656
0.031311
0.033268
0.021526
0.052838
0.021526
0.029354
0.031311
0.039139
0.037182
0.046967
0.050881
0.048924
0.017613
0.011742
0.005871
0.009785
0.039139
0.033268
0.033268
0.02544
0.037182
0.052838
0.021526
0.017613
0.037182
1
8,927
A
C
C
C
C
A
C
G
T
C
C
T
C
G
G
T
G
T
A
G
T
C
A
G
G
C
C
A
A
G
T
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C
C
G
G
A
A
T
A
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A
A
A
T
T
A
A
A
A
A
T
T
A
A
A
T
G
A
T
T
C
C
T
A
A
0.056751
0.023483
0.037182
0.029354
0.035225
0.033268
0.009785
0.033268
0.037182
0.017613
0.054795
0.019569
0.033268
0.027397
0.035225
0.027397
0.046967
0.04501
0.041096
0.015656
0.017613
0.007828
0.019569
0.039139
0.037182
0.029354
0.021526
0.035225
0.048924
0.031311
0.017613
0.035225
1
8,928
G
A
G
C
A
G
G
A
T
G
A
A
A
T
A
G
C
G
T
T
T
T
T
T
G
G
C
C
T
G
C
A
T
G
T
G
T
C
C
T
G
C
C
T
G
G
G
T
C
A
A
G
A
G
G
A
T
T
G
T
A
A
A
T
A
G
0.052838
0.023483
0.046967
0.029354
0.029354
0.015656
0.013699
0.017613
0.04501
0.041096
0.033268
0.009785
0.033268
0.02544
0.037182
0.029354
0.041096
0.043053
0.054795
0.035225
0.017613
0.033268
0.005871
0.043053
0.048924
0.017613
0.037182
0.039139
0.056751
0.005871
0.013699
0.023483
1
8,929
T
G
C
A
C
T
C
C
T
G
C
T
T
G
A
C
G
T
A
C
T
G
C
A
G
C
T
C
C
T
T
G
C
A
C
A
C
G
G
G
G
C
T
G
C
A
G
T
A
T
A
G
A
C
A
C
T
C
G
T
C
A
C
T
G
T
0.039139
0.029354
0.037182
0.027397
0.056751
0.031311
0.021526
0.037182
0.029354
0.033268
0.046967
0.017613
0.019569
0.02544
0.04501
0.056751
0.050881
0.033268
0.017613
0.005871
0.007828
0.015656
0.029354
0.029354
0.031311
0.029354
0.058708
0.013699
0.041096
0.031311
0.019569
0.031311
1
8,930
C
A
C
G
G
G
G
C
T
G
C
A
G
T
A
T
A
G
A
C
A
C
T
C
G
T
C
A
C
T
G
G
T
G
T
G
C
C
A
G
C
T
G
T
C
T
G
T
G
T
A
G
T
A
G
T
G
G
T
C
A
G
G
G
C
G
0.041096
0.033268
0.039139
0.023483
0.058708
0.031311
0.021526
0.037182
0.033268
0.033268
0.04501
0.015656
0.019569
0.031311
0.041096
0.056751
0.048924
0.033268
0.017613
0.005871
0.007828
0.015656
0.029354
0.029354
0.035225
0.027397
0.054795
0.013699
0.039139
0.029354
0.019569
0.031311
1
8,931
G
A
G
A
A
G
A
A
C
T
A
C
A
G
G
G
A
A
T
C
C
C
T
A
A
C
C
C
A
C
T
G
C
A
G
G
A
T
T
C
G
G
G
G
T
G
G
A
A
T
G
C
T
A
G
C
C
A
T
G
C
C
C
A
A
G
0.04501
0.02544
0.029354
0.052838
0.037182
0.019569
0.007828
0.035225
0.043053
0.027397
0.037182
0.039139
0.029354
0.043053
0.031311
0.033268
0.04501
0.033268
0.043053
0.003914
0.009785
0.005871
0.033268
0.035225
0.050881
0.017613
0.037182
0.019569
0.035225
0.021526
0.027397
0.04501
1
8,932
G
G
A
A
G
G
T
A
G
A
A
T
T
T
G
A
G
C
A
A
G
C
T
G
A
T
T
T
T
A
T
G
T
G
G
C
A
G
T
A
T
C
A
G
C
T
C
C
G
C
T
A
T
G
A
G
A
G
A
G
A
T
G
T
T
C
0.109589
0.015656
0.039139
0.074364
0.037182
0.011742
0
0.033268
0.048924
0.035225
0.023483
0.07045
0.029354
0.027397
0.039139
0.019569
0.046967
0.017613
0.007828
0.003914
0.001957
0.001957
0.02544
0.029354
0.041096
0.015656
0.041096
0.007828
0.02544
0.031311
0.048924
0.039139
1
8,933
T
G
A
A
A
A
G
G
A
T
A
T
G
G
C
G
A
A
G
G
C
C
A
C
C
C
A
G
C
T
G
C
T
G
A
A
G
G
A
G
G
C
C
G
A
G
G
A
A
G
A
A
T
T
C
T
G
G
T
A
C
C
G
T
C
C
0.037182
0.017613
0.043053
0.033268
0.029354
0.035225
0.009785
0.023483
0.048924
0.035225
0.054795
0.027397
0.031311
0.037182
0.033268
0.023483
0.054795
0.035225
0.031311
0.011742
0.007828
0.001957
0.023483
0.041096
0.04501
0.02544
0.033268
0.035225
0.031311
0.031311
0.015656
0.054795
1
8,934
T
G
G
T
C
T
A
A
A
T
G
G
C
T
T
A
G
A
C
A
G
G
C
T
T
C
T
G
T
G
C
T
T
T
A
T
G
A
T
T
G
T
A
A
A
A
G
A
G
T
T
A
C
A
G
G
T
G
A
G
C
C
T
T
T
A
0.072407
0.039139
0.048924
0.031311
0.039139
0.027397
0
0.039139
0.052838
0.023483
0.035225
0.029354
0.027397
0.052838
0.031311
0.021526
0.048924
0.039139
0.021526
0.003914
0
0.003914
0.027397
0.02544
0.048924
0.023483
0.023483
0.027397
0.023483
0.021526
0.039139
0.050881
1
8,935
C
G
C
A
G
A
C
T
A
A
C
A
A
A
A
C
T
G
T
T
A
C
C
T
T
G
A
T
G
A
T
G
C
C
A
A
C
C
A
A
A
G
T
C
G
T
T
T
T
C
A
T
C
A
T
T
A
A
G
A
T
G
C
C
T
G
0.080235
0.041096
0.035225
0.037182
0.054795
0.027397
0.003914
0.039139
0.050881
0.023483
0.027397
0.02544
0.019569
0.043053
0.04501
0.033268
0.04501
0.041096
0.013699
0.005871
0.005871
0.003914
0.019569
0.041096
0.031311
0.031311
0.029354
0.021526
0.023483
0.019569
0.037182
0.043053
1
8,936
G
A
T
G
C
A
T
T
T
C
T
T
A
C
T
T
T
T
C
T
C
A
C
A
T
A
G
G
A
T
A
C
C
A
A
C
T
C
T
C
C
A
G
A
A
T
A
G
T
A
C
T
G
T
G
A
C
A
C
G
C
T
G
A
G
G
0.11546
0.041096
0.04501
0.04501
0.050881
0.021526
0.005871
0.035225
0.046967
0.015656
0.029354
0.046967
0.029354
0.021526
0.041096
0.023483
0.04501
0.027397
0.031311
0.003914
0.007828
0.001957
0.017613
0.019569
0.041096
0.009785
0.029354
0.019569
0.019569
0.039139
0.048924
0.023483
1
8,937
T
A
T
C
A
G
T
T
G
T
A
C
A
G
T
T
T
T
T
C
T
G
C
C
C
G
C
A
G
C
A
G
T
A
G
A
A
T
C
A
T
C
A
T
A
A
T
T
T
A
A
A
G
A
C
A
A
T
A
T
T
T
G
T
T
G
0.093933
0.033268
0.039139
0.07045
0.037182
0.017613
0.011742
0.031311
0.04501
0.033268
0.02544
0.052838
0.02544
0.031311
0.027397
0.013699
0.043053
0.021526
0.011742
0.003914
0.011742
0.007828
0.035225
0.019569
0.058708
0.013699
0.019569
0.009785
0.023483
0.037182
0.056751
0.037182
1
8,938
T
T
T
T
G
A
G
A
T
C
T
C
T
C
T
G
A
A
C
C
A
A
G
C
T
T
G
A
A
G
G
T
T
T
T
C
T
A
G
T
A
A
T
A
C
A
G
A
A
A
T
A
A
G
A
A
A
A
T
A
C
T
G
A
A
C
0.086106
0.031311
0.046967
0.058708
0.041096
0.015656
0.009785
0.035225
0.046967
0.041096
0.02544
0.048924
0.023483
0.031311
0.029354
0.019569
0.04501
0.019569
0.007828
0.003914
0.009785
0.007828
0.037182
0.021526
0.052838
0.015656
0.027397
0.013699
0.019569
0.035225
0.054795
0.037182
1
8,939
C
A
G
A
T
A
T
C
C
T
C
G
C
T
G
G
G
C
G
C
C
G
G
G
G
G
C
T
G
C
A
G
C
T
C
G
C
T
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
G
T
A
G
A
A
G
T
T
C
T
C
G
0.013699
0.023483
0.023483
0.005871
0.015656
0.037182
0.02544
0.019569
0.037182
0.064579
0.041096
0.009785
0.011742
0.011742
0.015656
0.027397
0.058708
0.033268
0.064579
0.046967
0.041096
0.054795
0.019569
0.060665
0.031311
0.037182
0.048924
0.039139
0.04501
0.009785
0.007828
0.017613
1
8,940
G
C
G
A
G
G
A
T
A
T
C
T
G
G
A
A
G
A
A
A
T
T
C
G
A
G
C
T
G
C
T
G
C
C
C
A
C
C
C
C
G
C
C
C
C
T
G
T
C
C
C
C
T
A
G
C
C
G
C
C
G
C
T
C
C
T
0.017613
0.023483
0.023483
0.005871
0.019569
0.035225
0.02544
0.017613
0.035225
0.064579
0.037182
0.009785
0.017613
0.021526
0.015656
0.02544
0.056751
0.035225
0.054795
0.052838
0.041096
0.048924
0.015656
0.058708
0.031311
0.037182
0.041096
0.04501
0.04501
0.011742
0.005871
0.023483
1
8,941
C
T
C
A
T
T
G
T
T
G
C
C
C
C
T
C
T
T
T
T
C
T
G
C
C
C
C
T
C
A
G
G
C
T
G
C
C
T
G
G
A
G
G
T
A
T
T
A
T
G
C
T
A
C
C
A
A
C
C
C
C
A
A
C
A
T
0.048924
0.031311
0.035225
0.043053
0.035225
0.035225
0.007828
0.02544
0.046967
0.029354
0.041096
0.013699
0.015656
0.029354
0.043053
0.041096
0.050881
0.060665
0.046967
0.005871
0.009785
0.007828
0.011742
0.046967
0.048924
0.023483
0.029354
0.031311
0.039139
0.007828
0.017613
0.039139
1
8,942
C
C
G
G
G
C
T
G
G
C
C
C
T
C
A
A
G
G
T
G
C
A
G
G
A
G
C
A
A
C
A
C
C
G
T
C
A
G
A
A
G
C
A
C
T
T
T
G
A
G
A
A
A
A
G
G
A
G
G
A
A
G
C
C
A
T
0.011742
0.009785
0.043053
0.02544
0.101761
0.013699
0.005871
0.027397
0.031311
0.037182
0.050881
0.011742
0.009785
0.04501
0.027397
0.084149
0.058708
0.035225
0.052838
0.007828
0
0.001957
0.007828
0.037182
0.037182
0.033268
0.043053
0.027397
0.050881
0.021526
0.013699
0.035225
1
8,943
A
C
G
G
T
G
T
T
G
C
T
C
C
T
G
C
A
C
C
T
T
G
A
G
G
G
C
C
A
G
C
C
C
G
G
A
C
C
C
C
A
G
G
A
T
G
C
C
C
T
G
G
A
G
G
G
A
G
A
G
G
C
A
G
G
T
0.011742
0.011742
0.04501
0.02544
0.080235
0.017613
0.005871
0.029354
0.035225
0.037182
0.052838
0.009785
0.009785
0.04501
0.029354
0.062622
0.064579
0.041096
0.054795
0.007828
0
0.001957
0.007828
0.037182
0.043053
0.037182
0.04501
0.029354
0.054795
0.019569
0.009785
0.037182
1
8,944
C
G
C
C
A
A
T
T
A
A
G
G
A
A
A
A
G
G
T
G
G
C
G
G
C
A
A
T
C
A
G
A
C
G
G
C
C
T
T
C
C
C
A
C
G
T
T
T
T
G
G
G
T
G
T
C
T
T
G
T
C
T
C
C
A
A
0.039139
0.027397
0.062622
0.019569
0.031311
0.031311
0.015656
0.027397
0.041096
0.027397
0.056751
0.029354
0.031311
0.041096
0.041096
0.031311
0.033268
0.050881
0.029354
0.007828
0
0.007828
0.017613
0.035225
0.035225
0.021526
0.027397
0.039139
0.04501
0.02544
0.033268
0.037182
1
8,945
A
C
T
C
T
T
C
T
C
T
C
T
T
C
A
G
A
T
C
A
C
A
C
T
G
G
C
C
A
C
C
A
T
T
G
G
C
T
A
T
G
G
A
G
A
C
A
A
G
A
C
A
C
C
C
A
A
A
A
C
G
T
G
G
G
C
0.037182
0.027397
0.056751
0.027397
0.029354
0.033268
0.015656
0.029354
0.037182
0.02544
0.056751
0.033268
0.027397
0.041096
0.04501
0.027397
0.033268
0.048924
0.029354
0.007828
0
0.007828
0.021526
0.035225
0.031311
0.02544
0.027397
0.037182
0.043053
0.027397
0.035225
0.039139
1
8,946
A
G
A
A
T
T
G
G
C
C
T
C
C
A
A
G
G
T
A
G
T
G
A
C
T
C
A
C
C
A
G
G
C
C
C
C
A
C
C
A
C
A
G
G
G
C
A
T
C
T
G
C
A
T
A
G
G
T
C
T
C
A
A
A
C
A
0.029354
0.027397
0.039139
0.019569
0.031311
0.039139
0.011742
0.035225
0.062622
0.033268
0.046967
0.007828
0.017613
0.041096
0.031311
0.039139
0.064579
0.054795
0.019569
0.003914
0.005871
0.001957
0.015656
0.058708
0.043053
0.041096
0.033268
0.029354
0.037182
0.011742
0.011742
0.054795
1
8,947
A
G
G
A
G
T
T
T
G
A
G
A
C
C
T
A
T
G
C
A
G
A
T
G
C
C
C
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G
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G
G
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C
C
T
G
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G
A
G
T
C
A
C
T
A
C
C
T
T
G
G
A
G
G
C
C
A
A
C
0.029354
0.027397
0.039139
0.019569
0.031311
0.039139
0.011742
0.037182
0.062622
0.033268
0.046967
0.007828
0.017613
0.039139
0.031311
0.039139
0.066536
0.052838
0.019569
0.003914
0.005871
0.001957
0.015656
0.058708
0.043053
0.041096
0.033268
0.029354
0.035225
0.011742
0.011742
0.056751
1
8,948
A
A
G
A
A
A
T
G
A
A
G
A
A
A
G
G
A
T
G
A
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A
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C
G
T
G
A
T
G
A
G
T
T
C
C
T
G
A
A
A
G
A
G
0.033268
0.023483
0.033268
0.02544
0.037182
0.033268
0.007828
0.041096
0.064579
0.021526
0.043053
0.005871
0.033268
0.052838
0.021526
0.04501
0.058708
0.050881
0.015656
0.003914
0.003914
0
0.013699
0.064579
0.039139
0.033268
0.02544
0.023483
0.041096
0.017613
0.021526
0.064579
1
8,949
G
C
G
A
A
G
C
C
T
G
C
G
C
T
T
C
C
T
G
C
A
G
A
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C
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G
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A
C
C
G
G
A
G
A
G
G
T
G
G
C
A
C
C
T
G
G
A
A
0.019569
0.017613
0.04501
0.011742
0.041096
0.031311
0.003914
0.019569
0.043053
0.039139
0.058708
0.005871
0.027397
0.041096
0.031311
0.050881
0.072407
0.060665
0.04501
0.007828
0.005871
0.017613
0.005871
0.037182
0.039139
0.023483
0.07045
0.041096
0.054795
0.003914
0.003914
0.023483
1
8,950
G
C
A
A
T
G
T
T
C
T
G
G
C
C
A
C
C
T
C
C
C
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A
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A
T
C
C
T
G
C
G
C
A
T
G
C
T
G
C
G
G
A
T
G
A
0.019569
0.019569
0.046967
0.015656
0.043053
0.029354
0.003914
0.021526
0.043053
0.037182
0.052838
0.007828
0.029354
0.04501
0.033268
0.050881
0.068493
0.064579
0.039139
0.007828
0.005871
0.017613
0.003914
0.035225
0.039139
0.023483
0.066536
0.039139
0.054795
0.003914
0.007828
0.023483
1
8,951
A
A
C
A
T
C
C
A
G
C
A
G
C
C
C
A
G
A
T
C
C
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C
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C
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A
T
G
A
A
A
A
T
A
G
C
A
A
A
T
G
T
C
T
C
C
C
0.037182
0.033268
0.033268
0.02544
0.029354
0.021526
0.003914
0.02544
0.037182
0.046967
0.043053
0.011742
0.031311
0.037182
0.035225
0.023483
0.064579
0.052838
0.054795
0.021526
0.015656
0.009785
0.007828
0.04501
0.04501
0.019569
0.039139
0.04501
0.050881
0.003914
0.011742
0.037182
1
8,952
A
A
T
C
C
T
T
T
C
T
G
A
A
G
G
C
T
C
T
A
T
T
T
C
T
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C
C
A
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C
C
A
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T
A
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G
A
A
A
A
A
C
A
A
T
A
A
A
T
A
T
A
G
T
A
G
0.084149
0.037182
0.041096
0.088063
0.043053
0.017613
0.007828
0.037182
0.046967
0.019569
0.02544
0.064579
0.029354
0.021526
0.041096
0.017613
0.033268
0.019569
0.007828
0.001957
0.003914
0.001957
0.029354
0.02544
0.041096
0.011742
0.013699
0.011742
0.017613
0.037182
0.084149
0.037182
1
8,953
A
C
G
G
A
A
G
G
T
G
G
A
G
G
G
G
G
G
C
T
T
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A
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G
T
T
C
G
C
T
G
A
C
C
C
C
G
C
A
A
G
C
C
C
0.019569
0.021526
0.027397
0.009785
0.011742
0.039139
0.023483
0.017613
0.019569
0.043053
0.052838
0
0.009785
0.011742
0.015656
0.021526
0.052838
0.041096
0.091977
0.068493
0.02544
0.062622
0.007828
0.04501
0.033268
0.041096
0.029354
0.056751
0.064579
0.007828
0.007828
0.019569
1
8,954
A
A
G
C
A
C
C
T
C
T
C
T
C
T
C
C
C
A
C
A
G
G
C
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A
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C
G
A
A
C
C
A
G
T
G
G
G
C
T
G
C
T
T
T
C
C
C
0.041096
0.029354
0.041096
0.013699
0.039139
0.037182
0.007828
0.017613
0.062622
0.04501
0.048924
0.003914
0.02544
0.031311
0.029354
0.029354
0.064579
0.052838
0.048924
0.007828
0.013699
0.005871
0.017613
0.052838
0.039139
0.033268
0.023483
0.035225
0.037182
0.009785
0.015656
0.039139
1
8,955
T
C
T
C
G
G
G
C
C
C
C
A
C
A
G
G
C
T
C
T
G
C
C
A
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C
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A
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G
C
T
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G
C
C
G
C
C
A
G
G
G
C
T
C
C
T
G
G
A
G
C
C
0.007828
0.009785
0.013699
0.015656
0.029354
0.029354
0.019569
0.013699
0.031311
0.052838
0.058708
0.011742
0.017613
0.029354
0.023483
0.054795
0.068493
0.074364
0.062622
0.02544
0.009785
0.023483
0.009785
0.064579
0.015656
0.021526
0.046967
0.076321
0.050881
0.005871
0
0.02544
1
8,956
T
A
A
C
C
G
A
T
G
C
T
C
A
C
C
T
C
T
T
C
T
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T
C
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C
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A
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T
G
T
G
T
T
G
C
G
A
T
G
G
C
T
T
C
G
T
C
C
0.033268
0.039139
0.037182
0.017613
0.082192
0.02544
0.005871
0.029354
0.033268
0.033268
0.04501
0.003914
0.02544
0.043053
0.046967
0.062622
0.056751
0.04501
0.033268
0.003914
0.007828
0.005871
0.007828
0.037182
0.033268
0.019569
0.043053
0.033268
0.035225
0.021526
0.013699
0.039139
1
8,957
G
C
T
C
T
T
T
C
T
C
T
T
C
C
T
A
T
G
C
C
A
G
G
T
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C
T
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G
A
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A
C
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G
T
G
C
G
A
T
G
C
G
G
A
C
C
C
A
T
G
C
T
G
C
A
0.064579
0.029354
0.035225
0.04501
0.02544
0.033268
0.005871
0.035225
0.037182
0.033268
0.041096
0.021526
0.021526
0.046967
0.023483
0.029354
0.046967
0.04501
0.039139
0.003914
0.005871
0.007828
0.031311
0.033268
0.046967
0.017613
0.037182
0.019569
0.037182
0.023483
0.037182
0.039139
1
8,958
G
C
A
A
G
T
G
G
A
C
C
A
G
T
T
C
C
T
T
G
G
A
G
T
T
C
C
A
T
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T
G
C
T
G
C
C
C
C
G
C
C
C
C
T
G
G
C
A
G
A
G
A
G
G
C
G
C
T
T
C
C
A
G
G
A
0.037182
0.015656
0.039139
0.029354
0.019569
0.027397
0.001957
0.027397
0.046967
0.043053
0.048924
0.027397
0.027397
0.04501
0.029354
0.033268
0.056751
0.064579
0.037182
0.007828
0
0.005871
0.013699
0.056751
0.037182
0.009785
0.048924
0.039139
0.054795
0.017613
0.019569
0.031311
1
8,959
C
T
G
T
C
C
A
G
T
T
C
A
A
G
G
G
C
T
C
T
G
G
T
G
C
C
T
G
G
A
A
G
C
G
C
C
T
C
T
C
T
G
C
C
A
G
G
G
G
C
G
G
G
G
C
A
G
C
A
T
A
T
G
G
A
T
0.029354
0.019569
0.039139
0.027397
0.02544
0.023483
0
0.031311
0.046967
0.046967
0.046967
0.027397
0.02544
0.04501
0.027397
0.033268
0.060665
0.066536
0.037182
0.005871
0
0.005871
0.013699
0.058708
0.035225
0.009785
0.046967
0.041096
0.054795
0.017613
0.023483
0.027397
1
8,960
C
A
G
A
G
G
C
A
G
C
A
A
C
T
C
A
C
C
A
G
A
A
C
T
C
A
G
G
A
A
G
C
C
G
A
A
G
A
C
A
C
C
C
A
C
T
C
G
G
T
A
G
C
T
G
G
C
A
G
T
G
A
C
C
A
T
0.017613
0.021526
0.035225
0.013699
0.041096
0.029354
0.007828
0.031311
0.029354
0.054795
0.050881
0.019569
0.017613
0.035225
0.031311
0.046967
0.056751
0.064579
0.052838
0.013699
0.009785
0.003914
0.019569
0.052838
0.02544
0.027397
0.031311
0.046967
0.050881
0.013699
0.013699
0.033268
1
8,961
G
T
C
T
G
C
T
G
C
C
A
G
G
G
A
C
A
C
G
C
G
C
C
G
A
G
G
G
T
C
C
C
C
G
C
C
A
A
A
T
C
C
T
C
G
G
A
T
G
T
G
G
G
T
C
T
G
C
A
C
C
C
A
G
G
T
0.035225
0.019569
0.037182
0.011742
0.037182
0.041096
0.005871
0.027397
0.035225
0.039139
0.048924
0.013699
0.019569
0.021526
0.035225
0.050881
0.062622
0.064579
0.048924
0.027397
0.003914
0.017613
0.009785
0.043053
0.02544
0.029354
0.041096
0.048924
0.050881
0.011742
0.007828
0.027397
1
8,962
G
A
A
C
C
T
G
A
G
G
A
C
G
A
C
C
A
G
G
T
T
G
A
G
G
A
A
G
G
C
C
C
C
G
A
T
G
A
C
C
G
T
C
A
G
C
C
C
C
A
C
C
A
G
G
A
T
A
T
A
C
A
T
A
A
G
0.005871
0.019569
0.031311
0.003914
0.02544
0.037182
0.027397
0.02544
0.029354
0.039139
0.050881
0.011742
0.015656
0.039139
0.017613
0.041096
0.054795
0.043053
0.04501
0.046967
0.013699
0.037182
0.019569
0.039139
0.035225
0.035225
0.04501
0.058708
0.04501
0.019569
0.003914
0.037182
1
8,963
G
A
A
C
C
T
G
A
G
G
A
C
G
A
C
C
A
G
G
T
T
G
A
G
G
A
A
G
G
C
C
C
C
G
A
T
G
A
C
C
G
T
C
A
G
C
C
C
C
A
C
C
A
G
G
A
T
A
T
A
C
A
T
A
A
T
0.005871
0.019569
0.031311
0.003914
0.02544
0.037182
0.027397
0.02544
0.029354
0.039139
0.050881
0.011742
0.015656
0.039139
0.017613
0.041096
0.054795
0.043053
0.04501
0.046967
0.013699
0.037182
0.019569
0.039139
0.035225
0.035225
0.04501
0.058708
0.04501
0.019569
0.003914
0.037182
1
8,964
G
G
G
G
T
G
G
G
T
G
A
T
T
T
T
C
G
T
G
T
C
C
A
C
A
G
T
C
G
T
G
C
C
T
G
C
T
G
G
A
A
T
G
T
T
T
C
C
A
C
T
T
T
T
C
C
C
A
A
C
C
T
T
C
G
G
0.035225
0.029354
0.017613
0.027397
0.04501
0.035225
0.017613
0.027397
0.019569
0.027397
0.04501
0.009785
0.011742
0.021526
0.019569
0.054795
0.062622
0.064579
0.064579
0.035225
0.017613
0.019569
0.013699
0.02544
0.027397
0.02544
0.033268
0.072407
0.035225
0.015656
0.027397
0.015656
1
8,965
T
A
A
A
A
A
A
T
T
A
A
C
G
G
A
C
A
A
T
C
A
G
A
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C
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C
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A
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C
A
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G
A
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C
A
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A
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C
G
A
C
T
G
C
T
A
G
G
T
C
G
G
C
G
C
C
C
G
A
T
C
C
0.027397
0.021526
0.02544
0.02544
0.037182
0.023483
0.02544
0.021526
0.04501
0.037182
0.04501
0.005871
0.029354
0.023483
0.031311
0.043053
0.07045
0.043053
0.043053
0.031311
0.009785
0.015656
0.013699
0.037182
0.029354
0.035225
0.054795
0.052838
0.043053
0.007828
0.011742
0.033268
1
8,966
T
G
T
G
G
C
A
G
G
A
C
A
A
A
G
A
T
G
T
A
T
T
A
A
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T
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C
G
G
A
C
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A
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C
A
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A
C
C
T
C
A
A
C
C
A
T
G
A
T
C
A
G
A
G
C
G
A
T
0.027397
0.02544
0.027397
0.019569
0.039139
0.02544
0.023483
0.023483
0.04501
0.037182
0.04501
0.005871
0.027397
0.021526
0.029354
0.04501
0.072407
0.043053
0.046967
0.029354
0.009785
0.015656
0.013699
0.037182
0.02544
0.035225
0.054795
0.052838
0.039139
0.007828
0.017613
0.031311
1
8,967
C
T
T
C
A
C
C
G
C
G
T
C
C
G
A
A
G
G
C
T
G
C
T
C
T
A
A
C
C
C
T
C
T
T
G
G
C
G
G
G
G
G
C
C
G
A
G
A
A
G
T
G
T
G
G
T
T
T
G
G
C
T
T
C
C
C
0.015656
0.019569
0.027397
0.007828
0.035225
0.046967
0.021526
0.015656
0.033268
0.043053
0.043053
0.003914
0.011742
0.027397
0.011742
0.060665
0.072407
0.064579
0.076321
0.039139
0.007828
0.029354
0.001957
0.033268
0.031311
0.029354
0.041096
0.062622
0.037182
0.009785
0.011742
0.027397
1
8,968
C
C
C
T
G
C
C
G
C
C
C
T
G
G
G
T
T
C
A
G
A
G
T
T
C
C
G
A
G
T
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G
C
A
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G
T
C
T
C
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G
A
A
G
C
A
G
C
A
G
A
A
G
A
T
C
A
G
G
T
G
G
T
0.007828
0.017613
0.02544
0.001957
0.033268
0.043053
0.007828
0.023483
0.033268
0.046967
0.066536
0.009785
0.015656
0.015656
0.009785
0.056751
0.086106
0.046967
0.078278
0.02544
0.011742
0.021526
0.005871
0.054795
0.027397
0.027397
0.050881
0.052838
0.043053
0.007828
0.007828
0.037182
1
8,969
T
C
G
G
A
A
G
C
A
G
C
A
G
A
A
G
A
T
C
A
G
G
T
G
G
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C
G
G
C
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C
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G
A
T
G
C
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G
T
C
G
G
G
G
T
C
G
G
T
G
G
C
C
A
C
A
C
A
G
G
A
G
C
G
0.003914
0.017613
0.021526
0.005871
0.029354
0.043053
0.007828
0.021526
0.033268
0.048924
0.068493
0.011742
0.015656
0.015656
0.007828
0.054795
0.088063
0.046967
0.080235
0.02544
0.011742
0.021526
0.003914
0.058708
0.027397
0.02544
0.048924
0.056751
0.041096
0.005871
0.009785
0.041096
1
8,970
T
C
G
G
A
A
G
C
A
G
C
A
G
A
A
G
A
T
C
A
G
G
T
G
G
G
C
G
G
C
C
C
C
G
A
T
G
C
T
G
T
C
G
G
G
G
T
C
G
G
T
G
G
C
C
A
C
A
C
A
G
G
A
G
C
T
0.003914
0.017613
0.021526
0.005871
0.029354
0.043053
0.007828
0.021526
0.033268
0.048924
0.068493
0.011742
0.015656
0.015656
0.007828
0.054795
0.088063
0.046967
0.080235
0.02544
0.011742
0.021526
0.003914
0.058708
0.027397
0.02544
0.048924
0.056751
0.041096
0.005871
0.009785
0.041096
1
8,971
G
C
C
C
C
G
T
G
G
T
G
A
C
C
C
G
C
T
C
C
T
G
C
T
C
C
A
G
C
T
C
C
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G
T
G
T
G
G
C
C
A
C
C
G
A
C
C
C
C
G
A
C
A
G
C
A
T
C
G
G
G
G
C
C
C
0
0.013699
0.021526
0.007828
0.029354
0.04501
0.007828
0.019569
0.035225
0.046967
0.074364
0.005871
0.015656
0.013699
0.007828
0.054795
0.091977
0.043053
0.080235
0.02544
0.011742
0.021526
0.003914
0.058708
0.029354
0.027397
0.050881
0.060665
0.039139
0.005871
0.005871
0.04501
1
8,972
G
C
T
G
G
G
C
T
G
T
G
C
A
G
C
T
G
C
T
G
C
T
C
G
T
G
G
C
A
G
C
C
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G
G
A
G
C
A
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G
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G
T
G
G
T
G
A
G
T
G
G
G
C
C
G
C
A
G
G
C
C
0.005871
0.007828
0.021526
0.007828
0.019569
0.031311
0.015656
0.013699
0.033268
0.068493
0.07045
0.003914
0.015656
0.027397
0.015656
0.046967
0.084149
0.068493
0.07045
0.019569
0.005871
0.005871
0.007828
0.072407
0.017613
0.019569
0.04501
0.080235
0.046967
0.005871
0.005871
0.039139
1
8,973
G
A
G
C
A
G
C
A
G
C
T
G
C
A
C
A
G
C
C
C
A
G
C
G
A
G
A
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G
C
C
A
T
T
G
C
T
C
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G
T
G
C
T
C
A
G
A
A
G
T
G
A
T
G
A
G
A
G
G
T
A
G
C
C
G
0.005871
0.013699
0.019569
0.005871
0.02544
0.031311
0.015656
0.017613
0.031311
0.068493
0.066536
0.003914
0.013699
0.023483
0.015656
0.052838
0.084149
0.068493
0.07045
0.019569
0.005871
0.005871
0.007828
0.072407
0.017613
0.017613
0.043053
0.080235
0.04501
0.005871
0.005871
0.039139
1
8,974
T
T
G
G
C
T
T
T
G
G
C
A
T
G
C
G
C
C
A
G
T
G
C
C
T
T
G
G
G
C
G
G
C
G
C
C
T
G
G
C
A
G
A
G
G
C
A
G
A
G
A
T
G
C
T
G
C
T
G
C
T
G
C
T
G
T
0.005871
0.021526
0.011742
0.005871
0.021526
0.041096
0.009785
0.021526
0.031311
0.050881
0.054795
0.005871
0.011742
0.031311
0.021526
0.037182
0.078278
0.066536
0.086106
0.029354
0.009785
0.037182
0.011742
0.056751
0.015656
0.017613
0.054795
0.072407
0.037182
0.017613
0.001957
0.023483
1
8,975
G
C
A
G
C
A
G
C
A
G
C
A
T
C
T
C
T
G
C
C
T
C
T
G
C
C
A
G
G
C
G
C
C
G
C
C
C
A
A
G
G
C
A
C
T
G
G
C
G
C
A
T
G
C
C
A
A
A
G
C
C
A
A
A
G
T
0.005871
0.021526
0.011742
0.005871
0.021526
0.041096
0.009785
0.023483
0.031311
0.048924
0.054795
0.005871
0.011742
0.031311
0.021526
0.037182
0.076321
0.066536
0.086106
0.029354
0.009785
0.037182
0.013699
0.056751
0.015656
0.017613
0.054795
0.072407
0.037182
0.017613
0.001957
0.023483
1
8,976
C
T
G
C
C
T
C
T
G
C
C
A
G
G
C
G
C
C
G
C
C
C
A
A
G
G
C
A
C
T
G
G
C
G
C
A
T
G
C
C
A
A
A
G
C
C
A
A
A
G
G
G
C
A
C
G
T
G
G
T
A
G
A
A
G
G
0.005871
0.021526
0.015656
0.005871
0.021526
0.039139
0.009785
0.02544
0.031311
0.050881
0.052838
0.005871
0.009785
0.029354
0.021526
0.037182
0.076321
0.066536
0.084149
0.029354
0.009785
0.037182
0.013699
0.054795
0.019569
0.017613
0.054795
0.072407
0.037182
0.017613
0.001957
0.023483
1
8,977
A
C
T
T
C
T
A
C
C
A
C
G
T
G
C
C
C
T
T
T
G
G
C
T
T
T
G
G
C
A
T
G
C
G
C
C
A
G
T
G
C
C
T
T
G
G
G
C
G
G
C
G
C
C
T
G
G
C
A
G
A
G
G
C
A
T
0.005871
0.021526
0.015656
0.005871
0.021526
0.039139
0.009785
0.02544
0.031311
0.050881
0.052838
0.005871
0.009785
0.029354
0.021526
0.037182
0.076321
0.064579
0.084149
0.029354
0.009785
0.037182
0.013699
0.054795
0.019569
0.019569
0.054795
0.072407
0.037182
0.017613
0.001957
0.023483
1
8,978
C
C
A
G
G
C
T
C
T
A
C
C
C
T
G
T
G
G
G
T
C
T
G
T
T
T
C
T
G
G
A
G
C
G
A
G
T
G
G
C
G
A
G
C
T
C
A
G
A
C
T
T
G
G
T
G
C
T
T
C
A
G
A
A
C
G
0.005871
0.02544
0.031311
0.005871
0.019569
0.043053
0.015656
0.017613
0.041096
0.056751
0.056751
0.005871
0.017613
0.021526
0.013699
0.037182
0.060665
0.050881
0.088063
0.023483
0.017613
0.033268
0.021526
0.056751
0.037182
0.021526
0.039139
0.035225
0.052838
0.011742
0.011742
0.023483
1
8,979
G
G
C
A
A
C
C
A
C
C
G
A
G
C
T
G
C
C
C
T
T
G
C
T
G
C
G
T
G
C
G
G
C
C
C
T
C
A
A
G
G
A
G
A
C
C
T
T
G
C
G
G
T
G
G
G
T
G
C
T
G
G
C
T
G
A
0.007828
0.019569
0.029354
0.007828
0.027397
0.033268
0.017613
0.007828
0.037182
0.060665
0.068493
0.003914
0.013699
0.017613
0.021526
0.037182
0.091977
0.04501
0.09002
0.019569
0.005871
0.023483
0.001957
0.052838
0.023483
0.027397
0.066536
0.052838
0.046967
0.001957
0.011742
0.027397
1
8,980
C
C
T
G
G
C
G
C
A
G
G
G
C
C
T
G
C
T
G
C
A
C
G
T
T
G
G
G
G
T
T
C
C
G
A
G
C
C
A
G
C
T
C
A
A
A
G
A
G
C
G
T
C
A
T
C
A
G
C
A
A
G
G
G
A
T
0.015656
0.02544
0.021526
0.009785
0.027397
0.041096
0.017613
0.009785
0.031311
0.050881
0.066536
0.003914
0.013699
0.023483
0.029354
0.037182
0.09002
0.054795
0.088063
0.017613
0.005871
0.017613
0.001957
0.04501
0.023483
0.029354
0.068493
0.054795
0.043053
0.001957
0.003914
0.029354
1
8,981
T
T
C
C
C
T
T
G
C
T
G
A
T
G
A
C
G
C
T
C
T
T
T
G
A
G
C
T
G
G
C
T
C
G
G
A
A
C
C
C
C
A
A
C
G
T
G
C
A
G
C
A
G
G
C
C
C
T
G
C
G
C
C
A
G
G
0.015656
0.02544
0.021526
0.009785
0.027397
0.041096
0.017613
0.009785
0.031311
0.050881
0.066536
0.003914
0.013699
0.023483
0.029354
0.039139
0.09002
0.054795
0.088063
0.017613
0.005871
0.017613
0.001957
0.043053
0.023483
0.029354
0.068493
0.054795
0.043053
0.001957
0.003914
0.029354
1
8,982
C
T
C
T
A
T
G
G
A
A
C
T
C
A
C
T
G
C
A
G
G
G
A
G
C
G
T
G
G
A
C
A
C
G
G
T
C
A
G
G
C
C
G
G
C
A
A
C
C
A
G
C
C
C
C
A
C
C
C
A
G
A
G
A
G
T
0.019569
0.029354
0.023483
0.015656
0.037182
0.021526
0.017613
0.029354
0.029354
0.02544
0.052838
0.011742
0.029354
0.033268
0.035225
0.039139
0.062622
0.064579
0.066536
0.021526
0.009785
0.017613
0.009785
0.041096
0.027397
0.029354
0.039139
0.062622
0.054795
0.007828
0.005871
0.029354
1
8,983
C
C
G
C
A
A
T
C
G
G
T
T
G
A
A
G
C
G
C
C
A
T
T
C
A
G
G
C
C
C
A
T
T
C
C
T
A
C
A
G
A
G
G
C
C
A
G
G
G
C
A
G
A
G
C
T
T
G
T
G
A
G
G
C
C
G
0.007828
0.013699
0.035225
0.009785
0.029354
0.031311
0.015656
0.015656
0.039139
0.048924
0.068493
0.003914
0.023483
0.017613
0.017613
0.037182
0.088063
0.062622
0.07045
0.019569
0.011742
0.015656
0.011742
0.037182
0.037182
0.027397
0.041096
0.07045
0.048924
0.011742
0.003914
0.027397
1
8,984
C
A
T
T
T
G
T
G
C
C
C
A
C
G
A
T
G
T
T
G
T
C
T
G
T
A
G
G
C
C
A
C
C
C
A
G
G
G
C
T
C
C
A
G
G
C
T
C
A
T
C
C
T
G
T
G
G
G
G
A
T
G
C
A
G
G
0.011742
0.007828
0.021526
0.009785
0.04501
0.035225
0.021526
0.009785
0.02544
0.054795
0.056751
0
0.015656
0.02544
0.021526
0.064579
0.066536
0.068493
0.09002
0.02544
0.013699
0.013699
0.011742
0.046967
0.011742
0.029354
0.050881
0.062622
0.052838
0.009785
0.005871
0.013699
1
8,985
G
G
G
A
G
G
A
G
C
A
G
G
C
A
T
G
G
T
G
T
G
T
G
T
G
A
T
G
C
T
G
C
C
G
G
A
G
G
A
C
G
T
G
G
A
G
A
A
G
C
T
G
C
A
A
C
A
G
G
T
G
G
A
C
A
T
0.011742
0.009785
0.023483
0.007828
0.041096
0.031311
0.015656
0.015656
0.031311
0.060665
0.060665
0
0.017613
0.023483
0.021526
0.056751
0.074364
0.060665
0.076321
0.019569
0.013699
0.013699
0.011742
0.058708
0.009785
0.027397
0.058708
0.058708
0.050881
0.009785
0.009785
0.017613
1
8,986
G
C
A
G
A
T
G
C
A
A
G
A
C
T
A
G
T
T
A
A
T
C
G
C
T
C
T
G
A
A
A
G
T
G
A
G
G
A
G
G
G
G
G
G
A
C
G
T
G
C
C
A
G
G
C
C
T
C
A
A
T
A
T
G
A
C
0.009785
0.011742
0.037182
0.011742
0.023483
0.033268
0.013699
0.021526
0.033268
0.054795
0.07045
0.011742
0.015656
0.019569
0.02544
0.035225
0.088063
0.076321
0.074364
0.001957
0.005871
0.001957
0.017613
0.037182
0.023483
0.039139
0.04501
0.066536
0.050881
0.005871
0.011742
0.02544
1
8,987
C
C
T
C
G
G
G
C
G
G
C
G
C
C
T
G
G
C
A
G
A
G
G
C
A
G
A
G
A
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
A
C
C
A
C
G
T
A
A
G
C
A
G
G
C
C
T
G
G
G
G
C
0.011742
0.015656
0.017613
0.017613
0.027397
0.039139
0.011742
0.015656
0.027397
0.04501
0.060665
0.005871
0.021526
0.02544
0.023483
0.041096
0.074364
0.052838
0.084149
0.027397
0.013699
0.033268
0.013699
0.043053
0.019569
0.023483
0.056751
0.060665
0.041096
0.015656
0.007828
0.02544
1
8,988
G
T
G
G
A
A
G
G
A
G
C
A
C
T
T
T
G
A
G
G
C
C
T
G
G
G
A
C
T
G
C
A
T
C
T
T
C
C
A
G
T
A
C
G
G
T
G
A
G
G
C
C
A
G
G
G
A
C
C
C
G
G
G
C
A
A
0.015656
0.011742
0.02544
0.017613
0.021526
0.02544
0.003914
0.023483
0.023483
0.048924
0.064579
0.001957
0.023483
0.031311
0.021526
0.039139
0.074364
0.076321
0.086106
0.023483
0.007828
0.007828
0.003914
0.054795
0.031311
0.019569
0.043053
0.068493
0.072407
0.003914
0.001957
0.02544
1
8,989
G
A
A
G
G
T
G
C
T
G
C
A
G
A
A
C
G
C
C
C
G
G
G
G
G
A
G
C
C
T
G
A
C
C
C
T
G
G
A
C
G
T
C
C
A
G
C
C
C
A
G
C
A
T
C
T
T
C
C
A
C
T
A
C
A
T
0.005871
0.015656
0.035225
0.007828
0.023483
0.023483
0.009785
0.019569
0.031311
0.04501
0.068493
0.003914
0.021526
0.02544
0.021526
0.033268
0.082192
0.074364
0.080235
0.023483
0.007828
0.017613
0.007828
0.039139
0.035225
0.021526
0.046967
0.086106
0.058708
0.005871
0.001957
0.019569
1
8,990
G
C
T
C
G
T
C
C
C
T
G
G
G
C
A
G
G
G
A
C
T
T
G
C
A
G
G
T
G
T
A
G
C
A
C
C
G
C
A
G
C
A
G
C
A
C
T
G
G
G
G
A
C
A
A
G
G
C
G
G
G
C
T
C
A
T
0.005871
0.017613
0.021526
0.003914
0.033268
0.037182
0.017613
0.021526
0.019569
0.046967
0.062622
0
0.009785
0.017613
0.019569
0.058708
0.076321
0.048924
0.101761
0.033268
0.007828
0.029354
0.007828
0.04501
0.017613
0.029354
0.056751
0.066536
0.041096
0.005871
0.005871
0.033268
1