row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
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string
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string
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string
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string
f_10_ref__22
string
f_11_ref__21
string
f_12_ref__20
string
f_13_ref__19
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_32_ref_0
string
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string
f_34_ref__2
string
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string
f_36_ref__4
string
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string
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string
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string
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string
f_41_ref__9
string
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string
f_43_ref__11
string
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string
f_46_ref__14
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
9,191
C
A
C
C
A
C
T
T
T
G
A
A
C
T
C
C
A
C
A
G
C
A
C
G
C
A
T
C
C
C
A
C
C
A
C
G
G
A
C
A
A
G
A
A
A
A
A
T
G
T
C
T
C
C
T
G
C
G
A
G
A
G
C
A
A
T
0.037182
0.027397
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1
9,192
C
C
A
C
T
T
T
G
A
A
C
T
C
C
A
C
A
G
C
A
C
G
C
A
T
C
C
C
A
C
C
A
C
G
G
A
C
A
A
G
A
A
A
A
A
T
G
T
C
T
C
C
T
G
C
G
A
G
A
G
C
A
A
A
C
T
0.037182
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1
9,193
T
G
T
T
T
G
C
T
C
T
C
G
C
A
G
G
A
G
A
C
A
T
T
T
T
T
C
T
T
G
T
C
C
G
T
G
G
T
G
G
G
A
T
G
C
G
T
G
C
T
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G
A
G
T
T
C
A
A
A
G
T
G
A
0.037182
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1
9,194
G
C
C
A
A
A
A
A
C
C
C
C
A
C
A
C
A
C
A
C
C
T
G
A
T
G
A
C
A
T
C
C
C
C
T
A
G
G
C
G
T
A
C
A
C
G
A
A
G
G
T
T
A
T
T
C
C
G
A
A
C
A
A
C
T
T
0.037182
0.033268
0.050881
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0.021526
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0.041096
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0.007828
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0.052838
0.029354
0.035225
0.031311
0.046967
0.017613
0.019569
0.037182
1
9,195
T
G
A
A
T
A
G
A
G
T
T
G
T
T
C
G
G
A
A
T
A
A
C
C
T
T
C
G
T
G
T
A
C
G
C
C
T
A
G
G
G
G
A
T
G
T
C
A
T
C
A
G
G
T
G
T
G
T
G
T
G
G
G
G
T
G
0.037182
0.033268
0.048924
0.027397
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0.021526
0.060665
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0.043053
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0.031311
0.046967
0.017613
0.019569
0.037182
1
9,196
T
T
C
G
G
A
T
G
A
A
T
A
G
A
G
T
T
G
T
T
C
G
G
A
A
T
A
A
C
C
T
T
C
G
T
G
T
A
C
G
C
C
T
A
G
G
G
G
A
T
G
T
C
A
T
C
A
G
G
T
G
T
G
T
G
T
0.035225
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0.046967
0.015656
0.017613
0.037182
1
9,197
C
C
T
G
A
T
G
A
C
A
T
C
C
C
C
T
A
G
G
C
G
T
A
C
A
C
G
A
A
G
G
T
T
A
T
T
C
C
G
A
A
C
A
A
C
T
C
T
A
T
T
C
A
T
C
C
G
A
A
T
C
T
T
C
T
A
0.041096
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0.031311
0.043053
0.031311
0.04501
0.015656
0.017613
0.037182
1
9,198
C
C
C
T
T
A
G
G
C
A
T
C
A
T
C
C
T
T
C
T
T
T
C
T
C
T
C
C
A
G
G
T
C
T
C
T
C
C
C
C
C
T
G
T
A
C
C
T
A
G
A
A
A
G
C
T
A
T
T
T
G
A
G
C
T
T
0.027397
0.007828
0.043053
0.02544
0.02544
0.035225
0.009785
0.019569
0.052838
0.048924
0.058708
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0.027397
0.023483
0.027397
0.043053
0.058708
0.056751
0.050881
0.007828
0.005871
0.003914
0.029354
0.048924
0.041096
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0.02544
0.046967
0.041096
0.009785
0.007828
0.046967
1
9,199
A
T
G
C
A
T
A
G
C
C
G
A
C
G
T
C
A
T
G
C
A
A
G
T
A
T
A
C
A
T
A
C
C
T
G
G
G
C
A
C
A
T
C
T
G
C
A
C
A
C
T
G
A
G
G
A
G
G
A
A
G
T
C
C
T
G
0.023483
0.017613
0.039139
0.015656
0.052838
0.027397
0.007828
0.037182
0.035225
0.029354
0.046967
0.046967
0.021526
0.029354
0.033268
0.048924
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0.046967
0.054795
0.011742
0.007828
0.007828
0.017613
0.035225
0.027397
0.033268
0.04501
0.031311
0.046967
0.02544
0.011742
0.02544
1
9,200
T
G
G
T
A
T
C
C
T
G
G
C
C
G
C
T
G
G
C
T
A
C
C
C
A
T
T
C
C
A
G
T
C
C
A
C
G
A
C
T
A
A
T
T
A
G
G
G
C
G
G
C
T
G
C
C
C
G
A
A
G
C
T
G
C
T
0.021526
0.011742
0.046967
0.017613
0.046967
0.031311
0.007828
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0.052838
0.009785
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0.007828
0.019569
0.033268
0.029354
0.031311
0.039139
0.033268
0.048924
0.029354
0.021526
0.021526
1
9,201
A
C
T
G
G
G
G
G
A
C
A
C
A
A
C
A
G
C
A
G
A
G
C
T
G
G
A
G
A
G
T
C
T
G
G
A
G
C
T
G
C
T
A
G
T
T
G
A
G
G
T
A
G
G
G
A
A
C
T
G
C
C
A
G
G
C
0.039139
0.017613
0.04501
0.023483
0.033268
0.035225
0.003914
0.035225
0.039139
0.041096
0.058708
0.021526
0.027397
0.021526
0.039139
0.037182
0.048924
0.048924
0.052838
0.005871
0
0.001957
0.039139
0.041096
0.029354
0.02544
0.029354
0.029354
0.048924
0.027397
0.017613
0.035225
1
9,202
C
C
C
T
G
C
A
G
C
T
G
T
T
C
C
T
G
T
T
C
T
T
C
C
C
T
T
G
G
A
G
C
T
G
A
C
T
G
T
C
A
C
C
T
G
C
A
A
C
T
T
C
A
T
T
A
T
C
C
T
G
A
G
G
G
C
0.046967
0.037182
0.037182
0.029354
0.031311
0.037182
0
0.017613
0.058708
0.033268
0.056751
0.021526
0.041096
0.021526
0.043053
0.019569
0.064579
0.060665
0.048924
0.001957
0
0.001957
0.009785
0.054795
0.027397
0.023483
0.02544
0.02544
0.056751
0.005871
0.029354
0.031311
1
9,203
G
C
A
A
C
C
G
T
G
T
T
A
C
C
T
T
G
G
C
C
T
G
T
C
G
A
A
C
G
A
G
C
C
G
G
T
C
A
T
T
C
T
T
T
T
C
C
C
T
C
C
A
C
A
G
G
T
C
C
A
G
G
C
A
G
G
0.02544
0.017613
0.033268
0.011742
0.017613
0.043053
0.005871
0.017613
0.037182
0.048924
0.052838
0
0.019569
0.019569
0.029354
0.029354
0.064579
0.060665
0.082192
0.039139
0.017613
0.019569
0.001957
0.056751
0.027397
0.033268
0.039139
0.056751
0.054795
0.003914
0.005871
0.027397
1
9,204
C
C
C
C
G
G
A
A
C
T
C
C
T
C
C
T
G
C
A
T
G
T
G
T
C
G
G
T
A
G
A
T
T
T
G
A
G
G
G
A
C
C
A
C
A
T
A
A
T
C
C
A
A
G
T
C
A
G
C
T
T
G
A
G
A
G
0.007828
0.013699
0.031311
0.009785
0.031311
0.031311
0.005871
0.02544
0.035225
0.064579
0.054795
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0.017613
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0.088063
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0.017613
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0.046967
0.02544
0.033268
0.054795
0.046967
0.046967
0.017613
0.007828
0.033268
1
9,205
G
A
C
C
T
A
G
A
G
G
A
G
G
A
G
C
T
G
A
A
A
A
T
T
G
T
T
A
C
C
A
A
C
A
A
C
T
T
G
A
A
A
T
C
C
C
T
G
G
A
G
G
C
C
C
A
G
G
C
G
G
A
C
A
A
G
0.023483
0.013699
0.033268
0.015656
0.041096
0.029354
0.009785
0.017613
0.043053
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0.043053
0.052838
0.019569
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0.037182
1
9,206
T
G
C
C
T
T
T
C
A
G
A
G
G
A
A
T
G
A
A
G
G
T
C
A
T
C
G
A
A
A
A
C
C
G
G
G
C
C
A
T
G
A
A
G
G
A
T
G
A
G
G
A
G
A
A
G
A
T
G
G
A
A
C
T
G
T
0.009785
0.009785
0.029354
0.007828
0.015656
0.033268
0.001957
0.007828
0.04501
0.058708
0.09002
0.003914
0.02544
0.029354
0.009785
0.023483
0.080235
0.043053
0.04501
0.027397
0.015656
0.023483
0.005871
0.086106
0.037182
0.019569
0.037182
0.064579
0.062622
0.005871
0
0.04501
1
9,207
T
G
A
C
C
A
C
C
T
C
T
C
G
C
T
C
T
C
A
T
C
A
G
C
C
G
C
C
T
T
C
T
C
G
G
C
C
T
C
C
T
C
C
A
G
C
T
T
C
T
G
C
A
G
G
G
C
T
G
T
A
G
C
C
A
T
0.023483
0.015656
0.035225
0.015656
0.017613
0.035225
0.001957
0.003914
0.052838
0.04501
0.088063
0.007828
0.031311
0.033268
0.017613
0.013699
0.068493
0.037182
0.043053
0.023483
0.013699
0.019569
0.011742
0.074364
0.04501
0.02544
0.02544
0.058708
0.054795
0.003914
0.003914
0.052838
1
9,208
C
C
A
G
C
T
T
C
T
G
C
A
G
G
G
C
T
G
T
A
G
C
C
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C
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G
G
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C
C
A
G
C
T
C
C
T
C
C
T
C
A
A
C
C
A
G
C
T
G
A
C
0.029354
0.015656
0.033268
0.015656
0.019569
0.031311
0.001957
0.007828
0.054795
0.04501
0.082192
0.003914
0.031311
0.035225
0.013699
0.015656
0.074364
0.041096
0.041096
0.021526
0.013699
0.017613
0.011742
0.072407
0.04501
0.023483
0.029354
0.056751
0.054795
0.005871
0.005871
0.048924
1
9,209
A
G
G
C
T
G
A
G
G
C
A
G
A
T
G
T
G
G
C
C
T
C
C
C
T
G
A
A
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C
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C
A
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C
A
G
C
T
G
G
T
T
G
A
G
G
A
G
G
A
G
C
T
G
G
A
C
C
G
G
G
0.029354
0.015656
0.029354
0.017613
0.019569
0.033268
0.003914
0.009785
0.052838
0.039139
0.078278
0.003914
0.029354
0.035225
0.011742
0.019569
0.07045
0.043053
0.046967
0.027397
0.011742
0.019569
0.011742
0.068493
0.043053
0.023483
0.027397
0.062622
0.052838
0.007828
0.007828
0.046967
1
9,210
C
T
T
C
A
G
C
T
T
C
T
T
C
T
G
G
A
G
G
G
C
C
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C
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C
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A
G
C
T
G
G
G
A
C
A
G
A
G
G
G
G
A
C
T
T
G
G
T
C
A
G
C
C
T
0.023483
0.015656
0.041096
0.017613
0.02544
0.02544
0.005871
0.029354
0.039139
0.033268
0.066536
0.013699
0.015656
0.019569
0.019569
0.023483
0.064579
0.062622
0.093933
0.015656
0.001957
0.019569
0.009785
0.052838
0.041096
0.023483
0.015656
0.052838
0.068493
0.023483
0.015656
0.023483
1
9,211
G
G
G
C
G
C
G
G
A
A
C
C
T
G
A
C
G
C
T
G
G
C
G
G
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G
G
T
G
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T
G
C
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A
G
A
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C
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C
C
T
G
A
G
C
T
A
T
G
C
C
T
G
G
G
C
C
T
G
G
A
0.005871
0.017613
0.017613
0
0.023483
0.046967
0.011742
0.015656
0.023483
0.064579
0.062622
0.003914
0.005871
0.013699
0.013699
0.043053
0.088063
0.068493
0.084149
0.037182
0.005871
0.043053
0.017613
0.041096
0.017613
0.019569
0.050881
0.080235
0.039139
0.017613
0.003914
0.015656
1
9,212
G
G
T
T
T
G
T
C
A
G
C
T
C
C
G
A
A
C
T
G
G
A
A
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G
C
G
C
C
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C
T
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A
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C
C
T
G
G
C
A
C
C
G
C
T
G
A
G
C
G
C
T
G
T
G
G
A
C
C
0.013699
0.021526
0.017613
0.003914
0.029354
0.054795
0.013699
0.021526
0.015656
0.060665
0.04501
0.005871
0.005871
0.015656
0.017613
0.056751
0.086106
0.068493
0.068493
0.039139
0.009785
0.043053
0.011742
0.029354
0.019569
0.023483
0.052838
0.07045
0.027397
0.017613
0.007828
0.02544
1
9,213
C
T
G
C
T
G
C
C
T
C
T
G
T
G
G
C
C
C
G
C
T
T
T
G
C
C
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C
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C
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T
G
C
T
G
A
C
T
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G
G
T
G
C
T
G
T
G
G
0.013699
0.019569
0.019569
0.007828
0.033268
0.050881
0.013699
0.027397
0.017613
0.056751
0.052838
0.003914
0.007828
0.015656
0.023483
0.056751
0.084149
0.052838
0.050881
0.035225
0.015656
0.029354
0.013699
0.037182
0.017613
0.02544
0.064579
0.068493
0.023483
0.023483
0.005871
0.031311
1
9,214
G
A
A
G
T
G
C
C
C
G
T
G
T
A
G
T
G
T
C
A
C
C
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C
A
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T
C
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C
T
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G
G
G
A
G
C
A
G
A
G
G
G
G
C
C
A
G
T
G
C
G
A
A
C
C
A
T
0.017613
0.017613
0.021526
0.009785
0.029354
0.048924
0.011742
0.029354
0.015656
0.048924
0.054795
0.005871
0.009785
0.021526
0.023483
0.052838
0.074364
0.050881
0.060665
0.035225
0.019569
0.031311
0.011742
0.041096
0.017613
0.023483
0.056751
0.068493
0.021526
0.02544
0.007828
0.035225
1
9,215
G
C
T
G
C
C
T
T
G
C
T
G
T
A
C
C
T
G
G
A
T
G
C
T
C
G
C
A
C
A
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A
T
G
A
C
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C
C
T
C
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C
T
A
C
T
T
C
A
C
C
A
T
C
G
A
G
G
G
C
G
T
A
0.017613
0.017613
0.019569
0.011742
0.033268
0.04501
0.011742
0.029354
0.017613
0.046967
0.052838
0.009785
0.013699
0.02544
0.023483
0.056751
0.07045
0.052838
0.068493
0.029354
0.019569
0.021526
0.017613
0.039139
0.015656
0.023483
0.058708
0.064579
0.023483
0.021526
0.009785
0.031311
1
9,216
T
G
A
C
C
G
G
C
C
T
C
A
C
T
A
C
T
T
C
A
C
C
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G
A
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C
C
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G
C
A
G
G
G
C
A
G
C
A
A
C
C
T
C
A
G
T
G
A
0.017613
0.013699
0.023483
0.011742
0.037182
0.039139
0.013699
0.029354
0.021526
0.048924
0.050881
0.009785
0.017613
0.023483
0.023483
0.064579
0.07045
0.054795
0.064579
0.023483
0.017613
0.019569
0.015656
0.041096
0.017613
0.019569
0.058708
0.064579
0.02544
0.021526
0.007828
0.031311
1
9,217
T
T
C
T
T
C
C
C
A
G
C
G
A
A
T
A
C
G
C
C
A
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C
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C
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C
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C
C
T
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C
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C
A
G
C
A
T
C
A
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C
T
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T
C
T
G
T
A
A
G
G
0.017613
0.033268
0.043053
0.013699
0.043053
0.021526
0.003914
0.027397
0.041096
0.052838
0.054795
0.013699
0.021526
0.033268
0.033268
0.033268
0.076321
0.04501
0.04501
0.005871
0.009785
0.011742
0.015656
0.041096
0.041096
0.017613
0.058708
0.04501
0.039139
0.011742
0.017613
0.031311
1
9,218
C
T
T
G
G
C
C
C
C
A
G
C
G
G
G
G
A
T
C
C
A
G
T
T
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C
G
G
C
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C
G
C
T
C
A
T
G
A
C
A
G
C
C
C
A
T
G
G
G
A
A
A
T
A
C
C
A
G
A
T
C
T
T
T
T
0.021526
0.027397
0.037182
0.015656
0.035225
0.033268
0.003914
0.029354
0.043053
0.039139
0.048924
0.011742
0.031311
0.039139
0.027397
0.037182
0.066536
0.052838
0.056751
0.011742
0.007828
0.011742
0.009785
0.048924
0.043053
0.021526
0.037182
0.033268
0.046967
0.015656
0.009785
0.04501
1
9,219
G
T
C
T
C
A
A
G
T
C
C
T
C
C
A
A
C
T
G
T
G
T
G
G
T
G
G
A
T
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G
T
C
G
T
T
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T
G
C
T
C
A
A
A
A
T
C
A
C
A
G
A
C
T
A
T
G
G
C
C
T
G
T
0.041096
0.017613
0.035225
0.021526
0.029354
0.029354
0.001957
0.027397
0.043053
0.037182
0.043053
0.029354
0.039139
0.043053
0.031311
0.039139
0.052838
0.07045
0.054795
0.007828
0.007828
0.001957
0.019569
0.041096
0.031311
0.023483
0.031311
0.043053
0.048924
0.009785
0.011742
0.035225
1
9,220
T
G
A
A
T
G
A
A
G
A
G
C
T
A
G
T
T
T
T
G
C
T
G
A
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C
T
C
A
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G
A
C
C
C
A
G
C
T
G
A
G
C
G
G
C
C
A
G
A
C
C
0.021526
0.017613
0.050881
0.02544
0.013699
0.033268
0.001957
0.031311
0.043053
0.039139
0.054795
0.017613
0.033268
0.029354
0.035225
0.02544
0.050881
0.060665
0.056751
0.013699
0.007828
0.011742
0.02544
0.039139
0.041096
0.029354
0.029354
0.041096
0.054795
0.009785
0.017613
0.037182
1
9,221
A
A
A
G
C
A
G
G
T
A
T
A
C
A
G
G
T
C
A
T
T
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A
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A
A
G
T
G
T
C
A
C
T
A
C
C
T
A
A
A
A
G
G
G
A
T
A
G
A
A
A
A
G
C
A
G
A
G
G
C
C
C
T
G
T
0.033268
0.023483
0.041096
0.029354
0.043053
0.04501
0.001957
0.035225
0.048924
0.035225
0.037182
0.019569
0.023483
0.037182
0.035225
0.04501
0.04501
0.046967
0.056751
0.005871
0.003914
0.005871
0.029354
0.041096
0.033268
0.02544
0.023483
0.021526
0.023483
0.031311
0.02544
0.046967
1
9,222
A
G
A
C
T
C
C
A
T
T
C
G
A
G
A
A
G
C
A
G
T
G
T
T
C
A
C
T
G
T
G
T
C
T
C
C
A
A
A
A
A
G
A
C
A
A
T
A
A
C
G
G
G
G
C
A
T
C
T
T
C
A
G
G
C
T
0.039139
0.027397
0.035225
0.039139
0.021526
0.037182
0.007828
0.027397
0.050881
0.023483
0.039139
0.031311
0.019569
0.046967
0.039139
0.021526
0.037182
0.060665
0.046967
0.009785
0.017613
0.009785
0.029354
0.039139
0.037182
0.033268
0.037182
0.037182
0.035225
0.011742
0.02544
0.02544
1
9,223
C
T
A
A
T
G
T
C
T
T
A
C
C
T
T
G
A
C
C
A
T
T
A
G
A
C
T
C
C
A
T
T
C
G
A
G
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A
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C
A
G
T
G
T
T
C
A
C
T
G
T
G
T
C
T
C
C
A
A
A
A
A
G
A
T
0.037182
0.02544
0.035225
0.037182
0.023483
0.037182
0.007828
0.029354
0.050881
0.02544
0.039139
0.037182
0.021526
0.041096
0.037182
0.023483
0.039139
0.056751
0.048924
0.011742
0.015656
0.007828
0.031311
0.039139
0.035225
0.031311
0.037182
0.035225
0.035225
0.015656
0.02544
0.02544
1
9,224
G
G
T
T
G
A
C
C
C
C
G
C
C
C
T
G
C
T
G
G
G
T
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C
T
G
C
C
A
G
C
A
T
G
G
T
T
C
T
G
G
A
C
T
A
C
A
C
A
A
C
A
C
G
C
A
G
G
A
T
C
T
A
C
T
C
0.054795
0.027397
0.035225
0.033268
0.037182
0.033268
0.013699
0.027397
0.054795
0.023483
0.043053
0.019569
0.031311
0.033268
0.041096
0.031311
0.046967
0.052838
0.027397
0.011742
0.003914
0.005871
0.02544
0.041096
0.041096
0.041096
0.023483
0.017613
0.056751
0.013699
0.011742
0.039139
1
9,225
T
T
G
T
G
A
T
C
C
T
C
T
C
C
G
G
A
G
T
C
C
T
G
G
C
C
A
G
T
C
A
C
T
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C
A
C
A
T
T
G
T
C
A
A
A
G
A
C
G
T
C
A
T
T
C
G
C
C
A
G
C
0.052838
0.035225
0.033268
0.031311
0.037182
0.031311
0.017613
0.023483
0.048924
0.029354
0.041096
0.019569
0.031311
0.035225
0.039139
0.031311
0.054795
0.052838
0.021526
0.015656
0.003914
0.005871
0.015656
0.039139
0.041096
0.031311
0.035225
0.023483
0.054795
0.009785
0.021526
0.035225
1
9,226
G
G
C
T
G
T
G
G
G
T
G
C
G
C
T
C
C
A
T
C
T
C
A
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C
C
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A
G
C
T
G
C
G
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G
G
C
A
A
T
G
C
G
A
A
G
G
C
C
C
A
G
A
G
C
A
T
C
C
T
0.050881
0.021526
0.050881
0.021526
0.033268
0.035225
0.003914
0.017613
0.041096
0.052838
0.054795
0.015656
0.019569
0.029354
0.041096
0.043053
0.058708
0.048924
0.04501
0.005871
0.005871
0.007828
0.017613
0.037182
0.039139
0.013699
0.054795
0.04501
0.029354
0.011742
0.013699
0.033268
1
9,227
G
A
T
G
C
T
C
T
G
G
G
C
C
T
T
C
G
C
A
T
T
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C
C
A
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G
T
T
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C
G
C
A
G
C
T
T
G
G
A
T
G
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G
A
T
G
G
A
G
C
G
C
A
C
C
C
A
C
A
G
C
C
T
T
0.050881
0.021526
0.050881
0.021526
0.033268
0.035225
0.003914
0.017613
0.041096
0.052838
0.054795
0.015656
0.019569
0.029354
0.039139
0.043053
0.058708
0.048924
0.04501
0.005871
0.005871
0.007828
0.019569
0.037182
0.039139
0.013699
0.054795
0.04501
0.029354
0.011742
0.013699
0.033268
1
9,228
G
C
C
T
G
A
T
T
G
T
T
C
C
T
G
T
G
G
A
A
G
C
C
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C
A
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A
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C
C
T
C
T
G
G
A
A
T
G
G
C
C
T
T
G
C
A
G
A
C
0.043053
0.021526
0.050881
0.031311
0.031311
0.02544
0.005871
0.031311
0.046967
0.041096
0.043053
0.02544
0.027397
0.033268
0.031311
0.039139
0.050881
0.050881
0.037182
0.003914
0.009785
0.007828
0.023483
0.039139
0.054795
0.015656
0.035225
0.029354
0.043053
0.015656
0.017613
0.037182
1
9,229
T
G
C
A
C
C
C
A
T
G
G
C
T
T
C
C
A
C
A
G
G
A
A
C
A
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C
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C
C
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C
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A
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C
A
A
C
A
A
G
G
T
G
G
C
C
C
A
G
T
T
C
T
T
0.04501
0.021526
0.050881
0.031311
0.031311
0.019569
0.005871
0.031311
0.048924
0.046967
0.041096
0.021526
0.029354
0.037182
0.031311
0.037182
0.052838
0.046967
0.029354
0.003914
0.009785
0.007828
0.027397
0.037182
0.054795
0.013699
0.041096
0.033268
0.039139
0.015656
0.017613
0.039139
1
9,230
T
C
C
A
C
A
G
G
A
A
C
A
A
T
C
A
G
G
C
C
C
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G
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G
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C
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C
A
G
T
T
C
T
G
C
A
G
C
A
C
A
G
A
A
G
G
G
0.050881
0.021526
0.046967
0.035225
0.031311
0.019569
0.005871
0.029354
0.04501
0.04501
0.041096
0.021526
0.031311
0.039139
0.031311
0.037182
0.050881
0.048924
0.029354
0.003914
0.009785
0.007828
0.027397
0.037182
0.054795
0.011742
0.041096
0.031311
0.043053
0.015656
0.017613
0.037182
1
9,231
A
C
T
T
C
A
A
A
A
T
C
C
T
T
G
G
A
A
C
A
G
C
A
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T
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C
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C
C
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T
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G
A
A
C
T
G
C
A
A
T
A
T
A
C
A
A
A
A
A
G
T
T
0.066536
0.027397
0.052838
0.046967
0.02544
0.015656
0.005871
0.037182
0.043053
0.027397
0.033268
0.056751
0.033268
0.035225
0.046967
0.02544
0.035225
0.033268
0.023483
0.007828
0.009785
0.003914
0.015656
0.037182
0.04501
0.015656
0.039139
0.02544
0.033268
0.015656
0.035225
0.04501
1
9,232
G
A
A
A
G
T
T
G
G
G
A
T
G
A
T
G
C
T
C
A
A
T
G
C
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T
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C
C
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C
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C
C
A
T
C
T
C
T
T
T
G
C
T
C
C
C
T
A
T
G
T
0.082192
0.050881
0.037182
0.035225
0.029354
0.027397
0.017613
0.037182
0.029354
0.031311
0.02544
0.041096
0.029354
0.048924
0.043053
0.023483
0.037182
0.043053
0.02544
0.001957
0.009785
0.001957
0.021526
0.029354
0.046967
0.011742
0.031311
0.013699
0.029354
0.02544
0.033268
0.048924
1
9,233
T
A
A
C
A
T
T
G
G
A
T
G
C
A
C
T
T
A
T
C
T
C
A
T
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A
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C
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T
G
T
T
T
C
C
A
A
A
T
A
T
T
G
A
C
G
C
A
T
0.107632
0.035225
0.054795
0.082192
0.041096
0.015656
0.003914
0.037182
0.046967
0.017613
0.019569
0.029354
0.02544
0.039139
0.052838
0.021526
0.02544
0.021526
0.007828
0.001957
0.001957
0.003914
0.029354
0.011742
0.050881
0.021526
0.037182
0.007828
0.019569
0.019569
0.068493
0.041096
1
9,234
A
T
G
A
T
C
G
C
A
T
C
C
T
T
T
T
G
G
C
A
G
G
C
T
G
C
C
C
T
T
C
C
T
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T
G
A
C
A
A
A
C
T
T
C
T
C
T
C
A
G
C
C
A
A
G
A
A
C
A
A
A
G
A
C
C
0.048924
0.027397
0.035225
0.027397
0.041096
0.02544
0.005871
0.027397
0.043053
0.027397
0.04501
0.033268
0.039139
0.068493
0.031311
0.02544
0.050881
0.037182
0.013699
0.005871
0.007828
0.007828
0.029354
0.029354
0.037182
0.029354
0.037182
0.037182
0.02544
0.017613
0.021526
0.060665
1
9,235
T
G
C
C
A
A
A
A
G
G
A
T
G
C
G
A
T
C
A
T
G
G
T
C
C
T
C
A
C
A
C
A
T
G
G
A
T
A
T
C
A
G
G
T
G
C
T
G
C
T
C
T
G
C
A
C
T
G
C
G
G
G
T
G
C
C
0.037182
0.02544
0.033268
0.027397
0.041096
0.019569
0.005871
0.031311
0.039139
0.029354
0.04501
0.031311
0.043053
0.068493
0.031311
0.027397
0.054795
0.041096
0.015656
0.005871
0.007828
0.007828
0.031311
0.02544
0.037182
0.031311
0.039139
0.04501
0.029354
0.013699
0.017613
0.060665
1
9,236
C
T
T
G
T
A
A
C
C
G
T
G
C
A
G
A
T
T
A
T
T
C
T
A
A
A
C
T
T
G
C
C
C
C
G
A
T
C
A
T
G
T
T
T
G
G
C
A
T
T
A
A
A
A
C
C
G
A
A
C
C
T
G
A
G
T
0.080235
0.052838
0.048924
0.050881
0.027397
0.021526
0.003914
0.04501
0.050881
0.031311
0.021526
0.043053
0.027397
0.035225
0.039139
0.019569
0.031311
0.02544
0.013699
0.009785
0.007828
0.001957
0.037182
0.029354
0.054795
0.005871
0.029354
0.019569
0.015656
0.017613
0.058708
0.043053
1
9,237
T
A
G
A
A
T
A
A
T
C
T
G
C
A
C
G
G
T
T
A
C
A
A
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T
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C
A
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G
C
A
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T
T
T
C
G
G
T
T
A
T
T
T
C
C
A
T
T
C
T
T
C
G
0.088063
0.050881
0.050881
0.048924
0.029354
0.02544
0.003914
0.04501
0.048924
0.027397
0.019569
0.039139
0.02544
0.033268
0.043053
0.02544
0.027397
0.031311
0.015656
0.009785
0.007828
0.001957
0.035225
0.027397
0.052838
0.007828
0.031311
0.017613
0.017613
0.019569
0.054795
0.037182
1
9,238
G
A
C
C
C
T
C
C
C
C
G
G
G
T
A
C
C
C
T
C
C
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C
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C
C
C
C
C
C
G
C
T
G
G
A
C
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G
G
G
C
A
G
C
T
A
C
T
C
A
G
C
A
C
C
G
A
C
G
C
A
0.017613
0.013699
0.011742
0.011742
0.072407
0.031311
0.027397
0.013699
0.021526
0.054795
0.039139
0.003914
0.013699
0.021526
0.019569
0.082192
0.072407
0.039139
0.080235
0.031311
0.015656
0.031311
0.003914
0.041096
0.015656
0.039139
0.048924
0.041096
0.037182
0.009785
0.001957
0.035225
1
9,239
A
C
G
G
C
C
A
C
T
C
G
C
T
T
C
C
G
G
G
C
A
G
A
G
A
C
T
T
C
C
T
C
C
G
G
A
A
G
C
A
G
A
T
G
C
G
G
G
G
A
G
A
C
T
T
G
T
T
C
A
C
A
C
A
G
T
0.009785
0.019569
0.035225
0.003914
0.027397
0.056751
0.013699
0.02544
0.052838
0.039139
0.062622
0.009785
0.011742
0.013699
0.013699
0.058708
0.074364
0.043053
0.041096
0.031311
0.007828
0.017613
0.005871
0.064579
0.035225
0.029354
0.046967
0.04501
0.035225
0.015656
0.007828
0.04501
1
9,240
T
C
C
T
A
G
G
T
A
T
T
A
T
G
A
G
A
C
A
G
G
A
A
G
C
A
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C
A
A
G
C
C
T
G
G
G
G
T
A
A
T
T
G
G
A
G
G
A
T
C
C
A
A
A
C
C
A
A
A
G
G
T
C
G
G
0.07045
0.02544
0.029354
0.037182
0.033268
0.033268
0.017613
0.019569
0.02544
0.035225
0.039139
0.029354
0.033268
0.031311
0.041096
0.039139
0.046967
0.064579
0.035225
0.015656
0.005871
0.011742
0.019569
0.023483
0.029354
0.017613
0.031311
0.043053
0.043053
0.021526
0.021526
0.029354
1
9,241
A
C
C
A
T
G
G
C
T
G
A
C
C
C
G
A
A
G
C
T
G
C
C
T
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A
T
G
T
C
G
C
A
G
G
G
C
C
T
G
A
C
A
C
C
T
T
G
A
T
G
A
G
C
A
A
G
T
T
C
C
A
G
0.050881
0.019569
0.037182
0.02544
0.041096
0.027397
0.005871
0.029354
0.033268
0.039139
0.04501
0.015656
0.029354
0.039139
0.037182
0.035225
0.052838
0.046967
0.041096
0.015656
0.011742
0.013699
0.023483
0.033268
0.035225
0.035225
0.031311
0.037182
0.043053
0.011742
0.011742
0.04501
1
9,242
C
C
T
C
C
T
C
T
C
C
G
A
C
C
A
C
G
T
G
G
A
C
A
A
G
A
G
G
A
T
C
C
T
G
G
A
T
G
C
T
G
C
A
G
G
T
G
C
A
C
A
C
T
G
G
G
T
G
G
G
C
A
G
G
G
C
0.005871
0.005871
0.017613
0.001957
0.027397
0.029354
0.007828
0.013699
0.02544
0.056751
0.084149
0.003914
0.017613
0.007828
0.013699
0.050881
0.091977
0.056751
0.097847
0.027397
0.009785
0.021526
0.009785
0.062622
0.011742
0.019569
0.058708
0.082192
0.056751
0.001957
0
0.021526
1
9,243
T
A
G
G
C
C
C
C
C
T
C
C
A
G
A
T
C
C
C
A
A
G
C
T
G
C
A
G
T
T
A
C
C
G
C
T
T
C
T
T
G
A
T
T
T
C
A
T
C
C
A
A
A
G
C
C
A
A
G
T
G
G
T
C
G
A
0.04501
0.031311
0.039139
0.031311
0.050881
0.023483
0
0.033268
0.052838
0.029354
0.035225
0.02544
0.037182
0.035225
0.035225
0.041096
0.058708
0.037182
0.046967
0.005871
0.009785
0.003914
0.015656
0.037182
0.041096
0.021526
0.033268
0.027397
0.02544
0.013699
0.027397
0.048924
1
9,244
G
C
C
G
G
T
G
G
G
A
G
C
C
T
C
A
C
C
T
A
T
G
C
G
C
C
C
C
A
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C
C
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G
A
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G
A
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C
C
G
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C
A
G
T
G
C
T
C
T
G
C
G
T
G
A
G
T
C
C
A
T
T
0.027397
0.015656
0.033268
0.007828
0.02544
0.041096
0.013699
0.027397
0.041096
0.041096
0.050881
0.021526
0.021526
0.023483
0.023483
0.056751
0.060665
0.050881
0.058708
0.02544
0.009785
0.013699
0.009785
0.056751
0.013699
0.02544
0.050881
0.056751
0.029354
0.009785
0.019569
0.037182
1
9,245
C
G
A
A
T
G
G
T
T
T
C
A
G
A
C
G
C
C
G
A
G
C
A
A
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G
C
C
T
G
G
C
C
T
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A
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C
A
A
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G
A
G
A
G
T
C
C
A
T
G
T
C
T
C
G
T
T
C
C
C
A
T
0.027397
0.015656
0.015656
0.021526
0.039139
0.023483
0.003914
0.019569
0.043053
0.056751
0.062622
0.003914
0.017613
0.023483
0.017613
0.029354
0.099804
0.060665
0.064579
0.011742
0.007828
0.011742
0.015656
0.050881
0.027397
0.02544
0.043053
0.068493
0.041096
0.015656
0.007828
0.027397
1
9,246
C
T
C
A
G
T
G
T
C
T
A
C
C
C
C
T
G
A
G
C
T
G
G
C
T
G
C
C
C
A
A
T
C
T
G
A
T
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T
C
A
T
C
G
T
C
G
T
G
G
C
C
T
G
C
T
C
C
T
T
A
A
C
A
C
T
0.02544
0.035225
0.035225
0.011742
0.031311
0.033268
0.005871
0.035225
0.041096
0.039139
0.054795
0.003914
0.031311
0.023483
0.037182
0.033268
0.07045
0.060665
0.056751
0.009785
0.011742
0.001957
0.015656
0.048924
0.031311
0.027397
0.035225
0.043053
0.048924
0.009785
0.013699
0.037182
1
9,247
C
C
A
T
G
T
C
A
C
C
A
C
T
G
T
C
A
T
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C
C
C
A
G
G
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C
G
A
C
G
T
C
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T
A
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C
G
A
C
C
T
G
T
A
C
C
A
G
G
C
C
T
T
G
G
A
0.031311
0.023483
0.039139
0.017613
0.04501
0.043053
0.011742
0.043053
0.039139
0.023483
0.054795
0.015656
0.015656
0.013699
0.027397
0.048924
0.072407
0.048924
0.048924
0.007828
0.015656
0.003914
0.013699
0.033268
0.031311
0.037182
0.037182
0.037182
0.031311
0.033268
0.023483
0.031311
1
9,248
A
G
T
T
G
T
T
A
G
C
T
G
C
C
A
A
C
A
A
G
G
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A
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C
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T
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T
G
G
C
A
C
T
G
C
C
A
A
T
G
T
G
G
G
G
C
T
0.029354
0.031311
0.046967
0.017613
0.043053
0.031311
0.001957
0.027397
0.058708
0.04501
0.043053
0.013699
0.019569
0.027397
0.043053
0.043053
0.052838
0.054795
0.039139
0.013699
0.001957
0.005871
0.019569
0.056751
0.039139
0.015656
0.029354
0.048924
0.031311
0.015656
0.013699
0.039139
1
9,249
C
A
T
C
G
G
C
T
C
C
C
C
T
C
T
C
A
G
G
C
C
A
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C
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C
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T
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T
G
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C
A
A
G
G
A
C
A
T
G
G
T
G
T
T
G
C
G
G
G
C
0.027397
0.029354
0.04501
0.031311
0.041096
0.033268
0.001957
0.02544
0.060665
0.043053
0.037182
0.021526
0.019569
0.029354
0.043053
0.041096
0.048924
0.054795
0.037182
0.013699
0.001957
0.005871
0.017613
0.054795
0.041096
0.015656
0.029354
0.043053
0.029354
0.017613
0.021526
0.037182
1
9,250
C
A
A
C
T
T
G
C
T
G
G
C
T
G
G
C
C
T
G
A
G
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C
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C
A
A
G
C
T
G
T
A
G
C
C
A
A
A
C
A
G
T
A
C
0.029354
0.02544
0.046967
0.033268
0.041096
0.033268
0.003914
0.021526
0.064579
0.039139
0.037182
0.021526
0.019569
0.031311
0.04501
0.039139
0.046967
0.056751
0.035225
0.015656
0.001957
0.005871
0.015656
0.052838
0.041096
0.015656
0.029354
0.046967
0.029354
0.019569
0.021526
0.033268
1
9,251
T
G
G
A
G
A
T
A
G
T
A
T
T
T
G
G
A
A
T
G
A
A
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C
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A
A
A
C
C
A
T
C
C
A
G
C
A
G
A
C
T
T
T
A
C
0.093933
0.033268
0.052838
0.046967
0.039139
0.019569
0.007828
0.037182
0.050881
0.019569
0.031311
0.039139
0.027397
0.035225
0.033268
0.033268
0.039139
0.039139
0.013699
0.005871
0.001957
0
0.019569
0.027397
0.062622
0.017613
0.019569
0.015656
0.041096
0.017613
0.037182
0.041096
1
9,252
T
T
T
A
A
A
A
A
G
C
A
G
A
C
C
A
T
C
C
T
G
T
C
C
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A
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A
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T
C
C
A
T
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G
G
C
T
C
G
T
C
C
A
C
A
G
C
T
G
T
C
A
A
T
A
C
A
0.058708
0.037182
0.035225
0.056751
0.041096
0.021526
0.005871
0.041096
0.050881
0.02544
0.023483
0.031311
0.035225
0.041096
0.043053
0.02544
0.052838
0.056751
0.007828
0
0.001957
0
0.02544
0.027397
0.043053
0.029354
0.019569
0.019569
0.037182
0.017613
0.043053
0.04501
1
9,253
A
A
G
A
C
A
A
A
G
A
A
G
C
T
G
G
C
T
C
A
C
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C
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C
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G
A
A
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T
A
T
C
T
C
C
A
G
A
T
T
T
A
G
C
T
G
T
C
G
0.072407
0.027397
0.054795
0.046967
0.04501
0.023483
0.001957
0.029354
0.056751
0.033268
0.023483
0.037182
0.035225
0.041096
0.048924
0.027397
0.039139
0.041096
0.011742
0.007828
0.001957
0
0.019569
0.029354
0.04501
0.021526
0.02544
0.019569
0.029354
0.023483
0.035225
0.04501
1
9,254
G
T
A
C
C
G
G
A
A
A
C
G
G
T
G
T
T
T
G
G
T
G
G
A
G
C
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A
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G
G
C
C
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A
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C
T
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C
G
T
C
T
G
T
C
G
C
G
G
C
T
G
A
A
T
C
T
C
C
0.017613
0.021526
0.027397
0.007828
0.019569
0.050881
0.021526
0.017613
0.009785
0.052838
0.043053
0.007828
0.013699
0.013699
0.021526
0.041096
0.050881
0.041096
0.037182
0.078278
0.021526
0.078278
0.011742
0.033268
0.033268
0.033268
0.039139
0.060665
0.050881
0.013699
0.001957
0.027397
1
9,255
C
A
G
G
A
G
A
C
C
G
G
C
G
G
C
C
A
C
T
A
C
G
C
C
A
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A
A
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A
T
C
C
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C
A
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A
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C
A
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A
A
G
G
T
G
G
T
G
A
A
G
A
T
G
A
A
G
C
A
G
0.017613
0.029354
0.029354
0.001957
0.021526
0.037182
0.027397
0.019569
0.031311
0.039139
0.054795
0.003914
0.02544
0.031311
0.015656
0.029354
0.04501
0.04501
0.046967
0.04501
0.033268
0.046967
0.017613
0.050881
0.039139
0.023483
0.029354
0.058708
0.048924
0.023483
0.005871
0.02544
1
9,256
A
G
G
C
C
G
G
C
T
A
C
T
G
C
G
C
G
G
C
G
C
C
C
G
A
G
A
G
T
C
C
A
C
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T
G
C
T
G
C
T
C
C
G
G
G
T
C
T
G
C
C
G
C
C
C
G
C
T
C
C
G
C
C
C
A
0.015656
0.011742
0.017613
0.009785
0.011742
0.033268
0.017613
0.023483
0.027397
0.043053
0.039139
0.003914
0.005871
0.011742
0.011742
0.043053
0.062622
0.043053
0.066536
0.076321
0.015656
0.097847
0.015656
0.035225
0.015656
0.02544
0.066536
0.093933
0.031311
0.005871
0.013699
0.007828
1
9,257
T
G
A
A
A
G
A
C
T
A
G
C
A
G
A
G
G
A
A
A
C
G
C
T
G
G
A
C
T
C
T
T
T
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G
C
A
G
A
G
T
T
T
T
T
T
G
A
A
G
A
C
C
T
T
G
C
A
G
A
C
A
A
G
C
C
0.121331
0.027397
0.041096
0.04501
0.027397
0.027397
0.007828
0.039139
0.052838
0.033268
0.031311
0.021526
0.015656
0.035225
0.033268
0.02544
0.039139
0.031311
0.021526
0.003914
0
0.003914
0.033268
0.041096
0.039139
0.02544
0.033268
0.011742
0.027397
0.021526
0.041096
0.041096
1
9,258
C
T
G
G
G
T
G
G
A
G
A
T
C
T
A
G
G
A
A
C
C
T
A
T
G
T
G
A
T
C
A
A
C
A
A
G
C
A
G
A
C
G
C
C
A
A
A
C
A
A
G
C
A
A
A
T
C
T
G
G
C
T
A
T
C
G
0.076321
0.031311
0.048924
0.043053
0.062622
0.021526
0.001957
0.033268
0.052838
0.02544
0.035225
0.029354
0.033268
0.039139
0.039139
0.035225
0.035225
0.031311
0.011742
0.003914
0.003914
0.001957
0.033268
0.029354
0.04501
0.027397
0.015656
0.011742
0.037182
0.02544
0.039139
0.039139
1
9,259
A
C
C
T
A
C
A
T
A
C
C
T
G
G
A
T
G
G
A
G
A
A
G
A
T
A
G
C
C
A
G
A
T
T
T
G
C
T
T
G
T
T
T
G
G
C
G
T
C
T
G
C
T
T
G
T
T
G
A
T
C
A
C
A
T
A
0.084149
0.031311
0.050881
0.037182
0.064579
0.023483
0.001957
0.035225
0.048924
0.029354
0.033268
0.029354
0.027397
0.039139
0.039139
0.039139
0.035225
0.033268
0.013699
0.003914
0.003914
0.001957
0.031311
0.029354
0.039139
0.029354
0.015656
0.011742
0.035225
0.02544
0.039139
0.037182
1
9,260
C
A
A
C
A
A
G
C
A
G
A
C
G
C
C
A
A
A
C
A
A
G
C
A
A
A
T
C
T
G
G
C
T
A
T
C
T
T
C
T
C
C
A
T
C
C
A
G
G
T
A
T
G
T
A
G
G
T
A
T
G
T
T
C
A
C
0.080235
0.031311
0.048924
0.037182
0.064579
0.023483
0.001957
0.035225
0.048924
0.029354
0.035225
0.029354
0.027397
0.039139
0.037182
0.039139
0.037182
0.033268
0.013699
0.003914
0.003914
0.001957
0.031311
0.029354
0.039139
0.029354
0.017613
0.013699
0.035225
0.02544
0.039139
0.037182
1
9,261
A
C
A
G
G
A
T
T
C
C
A
A
A
A
G
A
G
G
A
T
T
T
G
G
A
A
T
T
G
C
A
G
T
G
T
C
C
G
G
A
G
G
C
A
G
A
G
A
C
A
A
C
C
C
C
C
A
C
T
T
T
G
A
A
A
C
0.101761
0.029354
0.037182
0.054795
0.041096
0.019569
0.005871
0.023483
0.037182
0.035225
0.037182
0.041096
0.019569
0.021526
0.043053
0.021526
0.050881
0.039139
0.031311
0.011742
0.001957
0.003914
0.011742
0.033268
0.043053
0.02544
0.017613
0.02544
0.043053
0.015656
0.037182
0.039139
1
9,262
G
T
A
G
T
A
C
T
C
A
A
C
T
G
C
A
T
G
A
A
T
T
A
A
C
T
C
C
T
C
A
T
C
A
T
C
A
A
A
G
T
G
G
A
G
G
T
G
A
A
A
G
A
A
G
T
G
T
T
T
C
T
A
C
C
G
0.086106
0.039139
0.029354
0.091977
0.039139
0.013699
0.001957
0.046967
0.031311
0.005871
0.019569
0.064579
0.035225
0.054795
0.039139
0.017613
0.021526
0.02544
0.003914
0.001957
0.007828
0
0.023483
0.029354
0.050881
0.009785
0.011742
0.005871
0.027397
0.037182
0.07045
0.056751
1
9,263
T
G
G
A
C
A
C
A
T
T
C
T
C
T
T
T
T
A
T
A
A
A
A
T
G
C
T
C
T
T
T
C
T
A
T
C
C
A
G
G
A
T
T
T
C
T
G
A
G
C
C
T
G
A
A
A
A
A
G
A
A
A
A
C
A
C
0.121331
0.027397
0.039139
0.082192
0.054795
0.019569
0.003914
0.02544
0.050881
0.011742
0.019569
0.076321
0.029354
0.035225
0.039139
0.029354
0.02544
0.011742
0.011742
0.003914
0
0
0.02544
0.017613
0.046967
0.017613
0.015656
0.003914
0.013699
0.029354
0.064579
0.046967
1
9,264
T
G
A
C
T
T
T
G
A
C
C
T
G
A
A
A
A
T
G
G
C
T
G
C
A
T
T
C
A
G
A
A
C
A
G
G
G
A
A
G
A
A
G
A
G
T
G
A
A
C
T
C
C
T
C
T
G
C
T
T
G
G
T
A
C
T
0.097847
0.027397
0.039139
0.052838
0.029354
0.029354
0.001957
0.04501
0.048924
0.02544
0.02544
0.033268
0.039139
0.031311
0.039139
0.037182
0.035225
0.035225
0.011742
0.003914
0.001957
0.003914
0.041096
0.029354
0.052838
0.013699
0.02544
0.003914
0.031311
0.027397
0.027397
0.052838
1
9,265
G
T
G
T
G
T
C
C
C
A
T
G
G
G
A
A
A
A
T
A
A
A
A
T
C
A
A
G
G
C
T
A
T
T
G
A
A
A
G
T
A
A
G
T
C
C
T
T
A
T
C
A
G
A
T
C
T
C
A
G
G
T
G
G
A
C
0.099804
0.043053
0.060665
0.035225
0.046967
0.021526
0.007828
0.04501
0.048924
0.021526
0.027397
0.021526
0.02544
0.023483
0.064579
0.023483
0.029354
0.033268
0.029354
0.001957
0.003914
0.001957
0.02544
0.02544
0.04501
0.029354
0.021526
0.009785
0.033268
0.02544
0.029354
0.039139
1
9,266
C
A
A
A
T
A
A
G
T
C
A
A
A
C
A
A
T
G
T
T
G
G
A
C
A
G
A
A
C
A
T
C
C
C
T
A
G
G
A
G
G
G
A
C
A
T
A
A
C
C
A
T
G
T
T
C
A
T
C
T
A
C
A
A
G
T
0.082192
0.035225
0.046967
0.07045
0.048924
0.009785
0.009785
0.027397
0.054795
0.017613
0.031311
0.029354
0.02544
0.046967
0.056751
0.019569
0.023483
0.027397
0.011742
0
0.001957
0.003914
0.029354
0.031311
0.04501
0.023483
0.031311
0.021526
0.027397
0.017613
0.050881
0.041096
1
9,267
G
T
A
G
A
T
G
A
A
C
A
T
G
G
T
T
A
T
G
T
C
C
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A
T
T
G
T
T
T
G
A
C
T
T
A
T
T
T
G
C
T
G
A
0.082192
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0
0.001957
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0.04501
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0.031311
0.021526
0.027397
0.017613
0.048924
0.041096
1
9,268
A
C
C
A
C
C
C
T
T
T
T
T
T
G
T
T
C
A
C
C
C
T
G
C
A
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C
T
G
G
G
A
A
A
C
A
A
T
G
G
T
G
G
G
A
C
T
0.078278
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0.052838
0.062622
0.04501
0.021526
0
0.027397
0.054795
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0.035225
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0.031311
0.062622
0.021526
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0
0.003914
0
0.029354
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0.039139
0.017613
0.031311
0.02544
0.023483
0.029354
0.037182
0.033268
1
9,269
G
C
A
A
A
A
C
C
T
C
A
C
A
A
A
A
C
A
T
G
C
C
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T
G
T
G
A
C
G
T
A
G
G
T
G
G
T
C
A
G
A
A
T
0.107632
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0.066536
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0.02544
0.003914
0.033268
0.043053
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0.003914
0
0.001957
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0.02544
0.031311
0.033268
0.02544
0.015656
0.027397
0.015656
0.054795
0.041096
1
9,270
G
A
A
G
A
T
C
A
G
A
G
C
G
A
G
G
A
C
G
T
T
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A
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G
A
A
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T
G
A
A
G
G
C
T
A
G
A
G
G
A
G
A
C
A
C
A
G
0.084149
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0.041096
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0.02544
0.037182
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0.041096
0.019569
0.02544
0.021526
0.037182
0.043053
1
9,271
A
C
A
A
T
C
A
A
A
A
G
A
T
G
G
T
G
G
G
A
G
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A
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C
A
T
T
G
T
G
G
A
C
A
G
G
A
A
G
A
G
G
A
C
0.052838
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0.02544
0.035225
0.033268
0.048924
0.021526
0.013699
0.043053
1
9,272
C
C
C
C
A
G
T
G
G
C
A
A
A
A
A
T
A
G
A
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G
G
A
G
C
A
C
G
A
T
T
T
C
C
C
A
A
G
C
T
C
0.082192
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0.043053
0.041096
0.035225
0.029354
0.003914
0.02544
0.048924
0.043053
0.031311
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0.029354
0.043053
0.033268
0.021526
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0.041096
0.029354
0
0.005871
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0.039139
0.046967
0.019569
0.017613
0.011742
0.031311
0.021526
0.037182
0.048924
1
9,273
C
C
A
A
C
A
C
T
G
C
C
G
A
C
T
G
C
A
G
A
A
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T
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C
C
C
T
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C
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A
G
A
T
G
G
T
A
A
G
A
C
A
T
T
A
C
C
T
T
C
0.072407
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0.066536
0.050881
0.039139
0.011742
0.003914
0.029354
0.062622
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0.031311
0.015656
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0.037182
0.013699
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0
0.029354
0.031311
0.062622
0.013699
0.046967
0.015656
0.035225
0.021526
0.050881
0.019569
1
9,274
A
G
A
A
A
G
C
A
A
T
C
A
A
C
A
G
G
T
T
C
A
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A
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A
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G
C
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G
G
T
A
G
A
C
A
G
C
T
T
G
C
A
A
G
A
A
T
C
0.084149
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0.041096
0.072407
0.054795
0.013699
0.003914
0.029354
0.046967
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0.060665
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0.056751
0.039139
0.031311
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0.023483
0.005871
0
0.003914
0
0.021526
0.017613
0.048924
0.009785
0.035225
0.011742
0.017613
0.02544
0.060665
0.04501
1
9,275
G
G
T
T
C
A
C
C
A
T
G
A
T
G
A
T
A
T
A
T
T
G
C
A
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G
T
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C
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C
T
T
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C
A
A
G
A
A
T
G
G
A
G
T
A
A
G
A
A
A
A
G
A
A
C
0.088063
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0.041096
0.074364
0.052838
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0.029354
0.04501
0.013699
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0.058708
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0.060665
0.039139
0.029354
0.029354
0.021526
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0.001957
0.001957
0
0.021526
0.015656
0.048924
0.011742
0.037182
0.011742
0.017613
0.027397
0.060665
0.046967
1
9,276
G
T
G
G
A
A
A
A
T
G
G
A
A
C
T
G
C
C
C
A
A
G
C
T
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G
A
T
C
T
C
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G
T
C
C
A
T
G
G
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G
C
A
T
C
C
A
G
A
A
C
T
T
T
A
C
T
A
T
G
C
T
0.093933
0.031311
0.056751
0.033268
0.037182
0.011742
0.001957
0.027397
0.062622
0.021526
0.048924
0.02544
0.027397
0.043053
0.02544
0.021526
0.035225
0.033268
0.043053
0
0
0.001957
0.009785
0.058708
0.052838
0.003914
0.027397
0.019569
0.050881
0.021526
0.04501
0.027397
1
9,277
T
G
A
A
G
C
C
G
T
A
T
T
G
G
A
A
G
A
A
A
T
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T
G
C
C
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T
A
G
T
A
A
G
T
T
A
A
A
T
T
T
A
A
A
A
A
A
0.172211
0.033268
0.046967
0.101761
0.027397
0.013699
0.003914
0.039139
0.02544
0.009785
0.021526
0.072407
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0.027397
0.003914
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0.001957
0.003914
0.017613
0.015656
0.035225
0.011742
0.015656
0.013699
0.023483
0.023483
0.097847
0.02544
1
9,278
G
C
T
T
T
T
A
T
G
G
A
A
A
T
C
T
A
A
A
A
A
T
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A
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A
A
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C
C
T
G
A
A
T
C
C
A
T
G
G
T
G
A
C
C
G
A
C
T
T
T
G
G
A
G
G
T
T
T
A
A
T
0.123288
0.031311
0.039139
0.07045
0.033268
0.029354
0.003914
0.029354
0.031311
0.021526
0.023483
0.062622
0.04501
0.021526
0.04501
0.02544
0.031311
0.033268
0.013699
0.009785
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0.005871
0.02544
0.011742
0.035225
0.015656
0.013699
0.009785
0.027397
0.023483
0.060665
0.043053
1
9,279
A
G
C
A
G
T
G
A
A
T
C
C
A
C
T
T
C
C
G
T
C
T
T
T
C
C
G
A
T
C
G
T
T
G
G
C
C
A
C
C
A
A
C
A
T
C
C
A
C
C
A
T
C
C
T
G
T
T
G
T
G
T
A
G
A
A
0.054795
0.029354
0.04501
0.033268
0.04501
0.035225
0.007828
0.029354
0.046967
0.037182
0.037182
0.017613
0.017613
0.041096
0.033268
0.039139
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0.04501
0.017613
0.011742
0.009785
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0.037182
0.050881
0.035225
0.031311
0.015656
0.043053
0.013699
0.023483
0.041096
1
9,280
A
A
G
C
A
G
T
G
T
A
T
C
C
A
T
T
T
T
C
T
T
C
T
C
T
C
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G
A
C
C
T
T
T
G
G
C
C
C
C
C
T
A
C
A
T
C
G
A
C
C
A
T
T
C
T
G
C
A
A
G
G
T
T
A
A
0.082192
0.031311
0.052838
0.076321
0.035225
0.021526
0.003914
0.048924
0.039139
0.009785
0.019569
0.058708
0.033268
0.04501
0.039139
0.023483
0.015656
0.023483
0.015656
0
0.007828
0.003914
0.031311
0.017613
0.04501
0.019569
0.011742
0.005871
0.015656
0.037182
0.076321
0.052838
1
9,281
A
A
G
C
A
G
T
G
T
A
T
C
C
A
T
T
T
T
C
T
T
C
T
C
T
C
T
G
A
C
C
T
T
T
G
G
C
C
C
C
C
T
A
C
A
T
C
G
A
C
C
A
T
T
C
T
G
C
A
A
G
G
T
T
A
G
0.082192
0.031311
0.052838
0.076321
0.035225
0.021526
0.003914
0.048924
0.039139
0.009785
0.019569
0.058708
0.033268
0.04501
0.039139
0.023483
0.015656
0.023483
0.015656
0
0.007828
0.003914
0.031311
0.017613
0.04501
0.019569
0.011742
0.005871
0.015656
0.037182
0.076321
0.052838
1
9,282
A
G
C
A
G
T
G
T
A
T
C
C
A
T
T
T
T
C
T
T
C
T
C
T
C
T
G
A
C
C
T
T
T
G
G
C
C
C
C
C
T
A
C
A
T
C
G
A
C
C
A
T
T
C
T
G
C
A
A
G
G
T
T
A
A
C
0.082192
0.031311
0.052838
0.074364
0.035225
0.021526
0.005871
0.048924
0.039139
0.009785
0.019569
0.058708
0.033268
0.04501
0.039139
0.023483
0.015656
0.023483
0.015656
0
0.007828
0.003914
0.031311
0.017613
0.04501
0.019569
0.011742
0.005871
0.015656
0.037182
0.076321
0.052838
1
9,283
A
G
G
G
G
T
A
T
T
C
G
A
T
G
A
T
C
C
C
T
G
T
G
G
T
G
G
G
G
A
C
T
C
G
A
A
C
T
C
T
A
A
G
C
A
C
A
T
C
T
T
G
T
T
G
C
G
T
A
G
G
C
A
G
G
A
0.066536
0.021526
0.052838
0.037182
0.043053
0.027397
0.005871
0.039139
0.043053
0.021526
0.04501
0.043053
0.027397
0.037182
0.029354
0.023483
0.033268
0.029354
0.023483
0.009785
0.007828
0.011742
0.031311
0.031311
0.043053
0.031311
0.009785
0.015656
0.039139
0.039139
0.039139
0.041096
1
9,284
T
C
T
G
C
T
T
G
A
T
A
A
A
C
G
T
A
C
T
C
T
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C
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A
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G
A
T
G
A
A
C
A
A
T
A
G
C
A
G
C
T
C
A
T
A
0.037182
0.033268
0.029354
0.031311
0.041096
0.031311
0.009785
0.029354
0.054795
0.033268
0.035225
0.027397
0.041096
0.052838
0.041096
0.035225
0.043053
0.04501
0.019569
0.003914
0.005871
0.003914
0.023483
0.054795
0.033268
0.023483
0.02544
0.023483
0.029354
0.019569
0.019569
0.062622
1
9,285
C
A
A
G
G
G
A
G
C
A
G
T
A
C
T
G
G
T
T
T
G
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A
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C
A
A
G
C
C
A
G
T
G
G
A
T
G
T
T
T
C
C
A
T
0.037182
0.031311
0.031311
0.017613
0.039139
0.035225
0.007828
0.043053
0.033268
0.027397
0.056751
0.02544
0.015656
0.027397
0.035225
0.041096
0.068493
0.043053
0.037182
0.007828
0.007828
0.007828
0.013699
0.046967
0.031311
0.035225
0.050881
0.027397
0.046967
0.017613
0.013699
0.039139
1
9,286
T
T
G
G
C
A
A
A
G
G
T
G
G
T
C
A
G
C
G
G
A
T
T
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A
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C
C
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G
A
G
C
T
T
C
G
A
T
C
A
A
A
A
T
T
G
A
T
T
0.097847
0.04501
0.050881
0.052838
0.041096
0.02544
0.005871
0.033268
0.033268
0.031311
0.033268
0.035225
0.041096
0.037182
0.031311
0.015656
0.031311
0.017613
0.011742
0.009785
0.011742
0.003914
0.031311
0.017613
0.037182
0.017613
0.013699
0.009785
0.02544
0.027397
0.080235
0.043053
1
9,287
C
T
G
C
G
A
G
T
T
G
A
G
G
C
T
G
T
T
G
A
T
T
C
A
T
C
A
G
A
G
T
C
T
A
G
C
A
G
G
A
G
G
A
A
T
T
A
T
T
G
G
G
G
T
C
A
A
A
G
G
T
G
C
T
A
C
0.101761
0.027397
0.041096
0.072407
0.035225
0.017613
0.001957
0.037182
0.035225
0.029354
0.029354
0.060665
0.017613
0.021526
0.052838
0.02544
0.037182
0.023483
0.019569
0.001957
0.009785
0.005871
0.019569
0.033268
0.037182
0.021526
0.037182
0.013699
0.023483
0.017613
0.050881
0.041096
1
9,288
G
G
A
C
T
T
T
G
G
G
A
T
G
T
C
C
C
G
G
G
A
C
G
T
G
T
A
C
A
G
C
A
C
T
G
A
C
T
A
C
T
A
C
A
G
G
G
T
G
A
G
T
A
G
C
T
G
T
G
C
A
G
A
T
C
T
0.021526
0.017613
0.02544
0.013699
0.033268
0.029354
0.017613
0.027397
0.02544
0.04501
0.046967
0.015656
0.023483
0.037182
0.02544
0.041096
0.07045
0.052838
0.062622
0.023483
0.015656
0.021526
0.011742
0.035225
0.02544
0.035225
0.050881
0.050881
0.041096
0.013699
0.005871
0.037182
1
9,289
G
T
C
T
C
T
G
A
T
C
T
G
C
A
C
A
G
C
T
A
C
T
C
A
C
C
C
T
G
T
A
G
T
A
G
T
C
A
G
T
G
C
T
G
T
A
C
A
C
G
T
C
C
C
G
G
G
A
C
A
T
C
C
C
A
C
0.021526
0.017613
0.02544
0.013699
0.033268
0.031311
0.017613
0.027397
0.02544
0.04501
0.04501
0.015656
0.02544
0.039139
0.02544
0.043053
0.07045
0.054795
0.056751
0.023483
0.015656
0.021526
0.011742
0.035225
0.02544
0.035225
0.050881
0.046967
0.043053
0.013699
0.005871
0.037182
1
9,290
G
C
A
A
C
A
G
C
C
C
C
T
T
A
G
C
A
T
G
G
T
A
A
A
T
T
G
T
A
G
G
A
T
G
T
A
A
A
T
C
C
G
G
A
C
T
T
G
G
A
C
T
T
T
G
C
C
A
C
T
G
C
C
T
A
A
0.082192
0.033268
0.054795
0.068493
0.041096
0.023483
0.003914
0.039139
0.023483
0.023483
0.023483
0.080235
0.027397
0.050881
0.046967
0.017613
0.015656
0.023483
0.013699
0.003914
0.003914
0.003914
0.02544
0.011742
0.029354
0.013699
0.029354
0.009785
0.017613
0.043053
0.078278
0.037182
1