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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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T
C
C
A
G
G
C
T
C
A
G
T
A
C
A
A
G
A
A
G
C
T
C
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C
G
C
A
A
A
G
C
G
T
G
C
G
G
A
T
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T
G
C
A
G
T
C
C
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C
C
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C
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C
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G
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A
G
G
A
T
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1
9,792
T
C
T
C
C
A
A
T
A
T
C
A
A
T
T
T
G
T
T
C
A
C
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T
T
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C
A
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A
A
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T
T
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C
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G
C
C
A
T
T
T
C
G
C
C
A
G
T
G
C
C
G
A
T
T
G
C
C
A
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1
9,793
A
A
T
G
C
T
T
A
C
C
T
T
C
C
G
G
A
A
T
C
C
C
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G
G
G
T
T
T
T
A
T
T
C
T
G
A
C
C
A
G
A
T
C
C
G
T
G
G
A
T
G
A
G
C
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A
A
G
G
A
T
G
G
A
G
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1
9,794
C
T
T
G
T
G
T
G
T
G
C
C
T
G
G
G
A
G
C
A
C
A
A
C
C
A
G
A
C
A
G
C
C
G
T
T
G
T
T
C
C
G
G
C
T
G
A
T
G
T
G
C
T
C
C
A
T
C
G
C
C
G
T
C
C
T
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1
9,795
C
A
G
G
C
A
A
G
A
A
G
A
C
G
T
C
C
C
G
T
C
A
C
C
C
C
C
T
G
C
A
C
C
A
G
G
A
C
C
T
G
C
A
C
T
A
T
T
T
C
C
C
C
T
T
C
A
G
G
C
C
C
A
G
C
A
0.07045
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0.04501
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0.011742
0.031311
1
9,796
A
G
A
T
T
G
T
T
G
T
G
A
C
T
C
T
C
T
T
A
C
C
A
G
C
T
G
G
T
C
A
C
T
G
T
C
C
G
G
G
A
T
C
A
G
T
T
A
T
G
T
A
A
G
G
G
G
G
T
C
A
T
T
T
A
C
0.121331
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0
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0.019569
0.011742
0.043053
0.019569
0.04501
0.029354
1
9,797
C
T
T
G
A
A
G
G
T
T
T
A
T
C
T
A
T
A
C
T
G
T
T
C
A
C
C
T
G
T
G
A
C
T
A
A
G
G
A
G
T
T
G
T
T
G
T
T
A
A
C
G
A
G
C
C
C
G
A
A
A
T
A
C
A
T
0.105675
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0.041096
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0.023483
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0.027397
0.058708
0.046967
1
9,798
G
G
G
G
C
A
G
A
T
G
G
C
C
G
A
G
T
A
T
C
C
A
A
C
T
A
T
C
T
C
C
A
T
A
G
A
C
C
G
C
T
T
C
G
A
T
A
G
G
G
A
G
A
A
C
C
T
G
A
G
G
G
C
C
C
C
0.019569
0.015656
0.033268
0.007828
0.013699
0.021526
0.011742
0.021526
0.027397
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0.046967
0.011742
0.021526
0.013699
0.02544
0.019569
0.048924
0.04501
0.072407
0.062622
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0.027397
0.029354
0.02544
0.084149
0.048924
0.003914
0.003914
0.02544
1
9,799
T
G
G
G
G
T
C
C
C
G
G
A
C
T
C
T
G
G
G
A
T
C
G
G
C
G
G
C
G
C
T
A
T
G
A
G
T
T
C
T
T
T
C
G
A
G
G
G
G
C
A
G
A
T
G
G
C
C
G
A
G
T
A
T
C
C
0.013699
0.013699
0.031311
0.005871
0.011742
0.021526
0.011742
0.023483
0.023483
0.052838
0.046967
0.009785
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0.054795
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0.076321
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0.02544
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0.033268
0.086106
0.046967
0.003914
0.003914
0.021526
1
9,800
G
C
C
T
C
T
T
T
G
A
T
C
C
T
T
G
C
C
T
G
C
A
A
A
A
G
G
C
A
C
T
C
C
G
A
T
G
G
C
A
A
T
G
T
C
T
A
A
A
A
A
C
A
G
A
C
A
T
A
A
A
A
C
A
T
T
0.062622
0.017613
0.04501
0.031311
0.041096
0.021526
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0.029354
0.043053
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0.031311
0.027397
0.037182
0.02544
0.041096
0.017613
0.033268
0.035225
1
9,801
A
T
A
T
T
C
C
C
A
G
C
A
A
T
G
G
T
G
A
T
T
T
T
T
C
A
T
A
G
C
C
T
C
C
A
T
C
T
C
T
G
G
C
A
G
A
A
T
A
C
A
G
A
A
A
T
T
A
A
A
A
T
T
T
A
T
0.091977
0.039139
0.027397
0.078278
0.043053
0.02544
0.001957
0.031311
0.04501
0.02544
0.007828
0.048924
0.035225
0.04501
0.052838
0.019569
0.033268
0.046967
0.021526
0
0.001957
0
0.021526
0.027397
0.031311
0.019569
0.015656
0.009785
0.019569
0.02544
0.060665
0.046967
1
9,802
C
A
C
C
T
G
C
C
G
G
C
G
C
A
G
C
T
C
C
C
G
C
A
T
C
T
C
C
T
C
C
T
C
G
T
A
G
A
G
G
T
C
C
C
C
C
A
G
G
C
G
C
G
A
C
T
T
G
C
C
T
T
G
G
C
T
0.001957
0.017613
0.029354
0.003914
0.017613
0.027397
0.017613
0.013699
0.02544
0.062622
0.054795
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0.019569
0.02544
0.02544
0.052838
0.043053
0.074364
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0.064579
0.007828
0.068493
0.019569
0.02544
0.050881
0.068493
0.050881
0.007828
0.005871
0.011742
1
9,803
C
A
T
G
C
T
T
G
A
C
A
G
A
C
G
C
C
T
T
A
T
A
G
C
T
C
C
T
C
A
A
A
C
T
A
A
A
T
A
C
A
T
T
A
T
T
C
C
T
G
G
G
G
T
A
A
G
C
A
T
A
C
G
G
G
T
0.060665
0.041096
0.058708
0.033268
0.037182
0.015656
0.007828
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0.043053
0.058708
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0.04501
0.017613
0.050881
0.023483
0.023483
0.021526
0.054795
0.027397
1
9,804
C
T
T
T
A
G
T
T
G
G
A
T
A
G
T
C
A
A
T
T
G
C
A
T
T
A
A
C
A
G
T
T
T
G
T
T
G
A
A
G
C
A
T
G
A
C
T
C
A
T
C
A
C
C
A
A
G
G
T
A
A
A
A
A
T
G
0.099804
0.035225
0.039139
0.066536
0.04501
0.021526
0.005871
0.033268
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0.052838
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0
0.037182
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0.019569
0.033268
0.009785
0.017613
0.02544
0.060665
0.041096
1
9,805
A
T
C
T
A
T
T
T
T
A
A
C
C
C
A
A
G
T
T
A
T
T
G
A
A
G
A
T
T
T
G
G
T
G
C
G
T
G
G
T
A
C
G
T
T
G
A
T
T
C
T
G
A
T
T
T
T
T
C
T
T
C
T
T
T
G
0.074364
0.037182
0.060665
0.043053
0.027397
0.023483
0.017613
0.023483
0.066536
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0.07045
0.015656
0.02544
0.021526
0.023483
0.019569
0.027397
0.04501
1
9,806
A
A
T
C
T
T
T
C
A
T
T
C
T
C
A
T
T
T
T
C
T
T
T
T
G
A
C
C
C
G
A
G
C
T
G
A
A
G
A
A
A
T
T
C
A
C
C
T
A
T
A
A
A
G
A
A
G
G
A
A
A
G
G
A
G
A
0.091977
0.035225
0.056751
0.058708
0.029354
0.02544
0.015656
0.017613
0.068493
0.033268
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0.019569
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0.003914
0.029354
0.027397
0.07045
0.015656
0.019569
0.017613
0.021526
0.019569
0.035225
0.039139
1
9,807
T
C
C
C
A
T
T
T
T
T
C
C
T
T
T
T
G
C
C
A
G
C
T
A
A
T
A
G
A
T
G
A
T
G
T
A
T
T
G
G
A
C
T
T
C
A
C
C
T
C
G
T
G
T
T
C
T
G
A
C
C
A
G
A
T
G
0.052838
0.02544
0.027397
0.029354
0.04501
0.027397
0.009785
0.027397
0.041096
0.037182
0.037182
0.023483
0.046967
0.048924
0.023483
0.033268
0.062622
0.037182
0.02544
0.011742
0.011742
0.009785
0.031311
0.021526
0.035225
0.02544
0.041096
0.02544
0.033268
0.02544
0.021526
0.04501
1
9,808
G
G
C
G
A
G
G
T
A
G
G
T
T
G
T
T
T
G
T
T
G
C
A
C
A
C
C
A
T
C
A
C
T
C
T
A
T
A
A
G
A
T
A
C
A
G
A
A
C
A
A
A
A
C
A
G
A
A
C
A
G
A
T
G
C
G
0.076321
0.041096
0.041096
0.04501
0.046967
0.011742
0.001957
0.041096
0.058708
0.033268
0.019569
0.043053
0.039139
0.04501
0.037182
0.021526
0.048924
0.017613
0.009785
0.001957
0.007828
0.003914
0.031311
0.031311
0.04501
0.015656
0.037182
0.015656
0.011742
0.023483
0.043053
0.052838
1
9,809
T
G
G
T
A
T
T
G
T
T
T
T
A
T
T
T
A
G
T
T
T
T
C
A
T
A
C
A
G
T
C
T
C
G
G
G
G
T
T
T
T
A
A
A
A
C
T
T
T
G
A
A
A
T
C
A
A
G
G
A
C
A
C
G
A
T
0.086106
0.027397
0.048924
0.052838
0.033268
0.019569
0.013699
0.031311
0.052838
0.02544
0.046967
0.050881
0.027397
0.013699
0.039139
0.019569
0.035225
0.021526
0.019569
0.005871
0.007828
0.003914
0.037182
0.035225
0.043053
0.027397
0.011742
0.021526
0.031311
0.023483
0.04501
0.041096
1
9,810
C
C
C
A
A
C
C
T
G
T
C
T
T
T
T
T
A
A
T
A
T
C
T
C
T
T
T
C
A
G
C
C
T
G
C
T
C
T
T
G
A
G
G
T
T
C
A
C
A
G
A
T
G
A
T
A
C
G
T
T
T
G
A
T
C
A
0.09002
0.02544
0.050881
0.07045
0.033268
0.021526
0.005871
0.021526
0.056751
0.015656
0.043053
0.048924
0.039139
0.02544
0.043053
0.019569
0.035225
0.027397
0.017613
0.001957
0
0
0.029354
0.023483
0.046967
0.009785
0.02544
0.02544
0.02544
0.027397
0.056751
0.037182
1
9,811
T
A
T
T
T
C
A
G
T
T
T
A
T
G
A
T
G
T
C
A
C
A
A
G
A
A
G
A
G
A
T
A
C
A
T
T
T
G
T
T
A
A
A
C
T
G
G
A
T
A
A
T
T
G
G
T
T
A
A
A
T
G
A
A
T
G
0.103718
0.029354
0.046967
0.082192
0.048924
0.011742
0.007828
0.029354
0.035225
0.019569
0.021526
0.068493
0.027397
0.052838
0.041096
0.021526
0.017613
0.021526
0
0
0.013699
0.001957
0.033268
0.007828
0.052838
0.019569
0.02544
0.011742
0.019569
0.027397
0.062622
0.037182
1
9,812
T
T
G
C
G
G
A
G
A
T
C
T
G
A
T
A
G
T
C
C
T
G
A
A
A
A
C
A
A
A
T
A
C
A
G
T
G
A
C
A
G
C
A
C
A
G
G
T
C
A
C
A
G
T
A
A
G
G
C
C
A
A
A
A
A
A
0.109589
0.037182
0.041096
0.046967
0.048924
0.019569
0.001957
0.046967
0.046967
0.015656
0.019569
0.041096
0.035225
0.037182
0.029354
0.033268
0.033268
0.017613
0.017613
0.009785
0.005871
0.009785
0.023483
0.031311
0.037182
0.015656
0.017613
0.011742
0.015656
0.031311
0.060665
0.050881
1
9,813
T
C
C
A
C
G
C
T
C
A
C
C
G
A
T
G
T
G
G
G
G
G
C
T
G
G
C
A
G
G
G
T
C
G
C
T
G
G
C
T
C
T
C
A
T
G
T
A
T
C
G
A
G
G
G
G
T
G
T
C
T
T
C
C
T
G
0.04501
0.015656
0.039139
0.033268
0.033268
0.02544
0.003914
0.02544
0.039139
0.054795
0.043053
0.02544
0.029354
0.02544
0.02544
0.046967
0.062622
0.052838
0.035225
0.005871
0.017613
0.015656
0.011742
0.048924
0.043053
0.009785
0.037182
0.041096
0.037182
0.015656
0.017613
0.037182
1
9,814
T
T
T
G
C
T
T
A
T
G
T
T
G
A
G
A
G
A
A
G
T
T
T
C
A
A
A
T
G
G
A
T
T
C
T
G
A
A
T
G
T
A
C
A
G
A
G
G
A
G
A
A
G
A
A
T
C
A
G
G
T
T
T
G
T
C
0.121331
0.035225
0.054795
0.050881
0.052838
0.015656
0
0.031311
0.04501
0.02544
0.027397
0.037182
0.027397
0.035225
0.050881
0.015656
0.035225
0.02544
0.02544
0.003914
0.007828
0
0.015656
0.023483
0.04501
0.009785
0.029354
0.015656
0.023483
0.039139
0.04501
0.029354
1
9,815
C
T
T
T
C
T
G
C
G
C
T
T
A
C
A
C
C
T
G
G
G
G
C
C
A
T
C
C
G
C
C
A
T
G
A
T
C
C
T
C
T
C
G
C
T
T
G
T
G
T
C
T
A
A
A
T
G
C
T
C
G
A
G
T
C
G
0.02544
0.015656
0.023483
0.011742
0.013699
0.033268
0.011742
0.021526
0.019569
0.043053
0.052838
0.001957
0.007828
0.009785
0.017613
0.035225
0.029354
0.02544
0.125245
0.076321
0.019569
0.060665
0.015656
0.066536
0.021526
0.015656
0.035225
0.068493
0.052838
0.013699
0.011742
0.017613
1
9,816
T
G
C
T
T
T
C
T
G
C
G
C
T
T
A
C
A
C
C
T
G
G
G
G
C
C
A
T
C
C
G
C
C
A
T
G
A
T
C
C
T
C
T
C
G
C
T
T
G
T
G
T
C
T
A
A
A
T
G
C
T
C
G
A
G
T
0.02544
0.015656
0.023483
0.011742
0.013699
0.033268
0.011742
0.021526
0.019569
0.043053
0.050881
0.001957
0.007828
0.009785
0.017613
0.035225
0.029354
0.02544
0.125245
0.076321
0.019569
0.060665
0.015656
0.066536
0.021526
0.015656
0.035225
0.068493
0.054795
0.013699
0.011742
0.017613
1
9,817
T
T
G
C
C
T
G
G
T
T
C
A
G
G
A
G
A
A
G
A
T
G
G
T
T
C
A
G
A
A
G
A
C
T
G
C
A
C
T
G
A
A
A
T
C
T
G
T
C
C
A
G
C
T
T
G
C
A
T
C
T
T
T
T
C
A
0.060665
0.029354
0.043053
0.031311
0.031311
0.035225
0
0.043053
0.048924
0.037182
0.041096
0.011742
0.035225
0.031311
0.041096
0.029354
0.066536
0.04501
0.021526
0
0
0
0.021526
0.041096
0.039139
0.017613
0.043053
0.013699
0.037182
0.033268
0.023483
0.046967
1
9,818
T
T
A
G
G
C
A
A
C
T
T
T
A
G
C
G
A
G
T
A
T
A
G
A
T
G
C
T
G
A
G
C
T
T
C
A
G
A
A
A
C
T
T
A
A
G
G
A
A
A
T
G
A
C
C
A
A
C
C
A
C
C
A
G
A
C
0.099804
0.041096
0.046967
0.050881
0.035225
0.027397
0.007828
0.043053
0.041096
0.029354
0.021526
0.048924
0.027397
0.039139
0.035225
0.017613
0.027397
0.027397
0.009785
0.003914
0.011742
0.003914
0.041096
0.021526
0.041096
0.011742
0.019569
0.013699
0.011742
0.043053
0.062622
0.037182
1
9,819
A
G
T
G
A
A
A
G
A
A
G
T
T
T
T
A
C
A
G
G
C
C
C
T
A
G
A
A
G
A
A
C
T
T
G
C
T
G
T
C
A
A
T
T
A
T
G
A
T
C
A
G
A
A
G
T
C
T
C
A
G
G
A
A
G
C
0.097847
0.031311
0.068493
0.060665
0.031311
0.017613
0
0.039139
0.043053
0.02544
0.027397
0.054795
0.029354
0.039139
0.041096
0.015656
0.02544
0.019569
0.011742
0.003914
0.009785
0.001957
0.029354
0.011742
0.068493
0.015656
0.017613
0.013699
0.017613
0.02544
0.050881
0.054795
1
9,820
G
A
A
T
G
G
G
G
A
T
A
T
T
C
C
T
T
T
C
C
A
T
C
G
T
C
C
A
C
G
G
C
C
G
C
G
G
A
T
A
A
T
C
A
G
A
G
G
C
A
G
G
G
G
A
T
G
C
A
A
T
G
A
G
A
A
0.052838
0.021526
0.039139
0.058708
0.019569
0.02544
0.007828
0.02544
0.064579
0.023483
0.031311
0.039139
0.041096
0.04501
0.019569
0.015656
0.046967
0.029354
0.02544
0.013699
0.015656
0.009785
0.013699
0.046967
0.048924
0.02544
0.029354
0.015656
0.033268
0.015656
0.050881
0.048924
1
9,821
T
A
C
C
A
G
C
A
T
C
T
G
C
C
G
T
C
A
C
A
A
A
C
C
C
C
A
C
A
T
C
A
T
C
A
T
G
G
G
A
G
C
T
G
G
A
A
G
A
G
G
A
C
T
G
G
T
C
A
G
A
G
A
G
A
C
0.074364
0.02544
0.039139
0.056751
0.043053
0.023483
0.003914
0.037182
0.046967
0.033268
0.017613
0.048924
0.033268
0.041096
0.023483
0.023483
0.050881
0.039139
0.021526
0.005871
0.009785
0
0.023483
0.021526
0.035225
0.027397
0.019569
0.017613
0.021526
0.031311
0.064579
0.039139
1
9,822
G
A
T
C
T
C
G
G
G
A
C
T
T
G
A
G
G
A
T
T
T
T
C
T
T
A
T
A
C
C
A
G
C
G
A
T
G
T
T
T
C
T
T
C
A
G
A
C
G
C
A
T
C
T
G
A
G
G
G
G
A
C
G
A
G
T
0.056751
0.023483
0.037182
0.046967
0.037182
0.033268
0.013699
0.017613
0.035225
0.027397
0.041096
0.041096
0.033268
0.039139
0.041096
0.029354
0.041096
0.04501
0.048924
0.005871
0.013699
0.009785
0.009785
0.029354
0.037182
0.019569
0.035225
0.021526
0.037182
0.029354
0.029354
0.033268
1
9,823
T
C
C
G
C
C
T
G
G
G
C
C
A
G
C
A
T
C
T
C
T
A
C
G
G
C
A
C
G
T
A
C
C
G
C
A
C
A
C
G
G
C
T
G
C
A
T
G
A
G
A
A
C
A
A
C
T
G
G
A
T
C
T
G
C
T
0.029354
0.009785
0.04501
0.015656
0.02544
0.029354
0.019569
0.021526
0.023483
0.048924
0.056751
0.007828
0.019569
0.027397
0.015656
0.046967
0.052838
0.050881
0.066536
0.035225
0.005871
0.021526
0.011742
0.041096
0.029354
0.017613
0.037182
0.060665
0.052838
0.021526
0.02544
0.027397
1
9,824
G
A
C
C
A
C
A
G
C
A
C
G
C
G
C
G
G
A
C
A
A
G
C
A
C
C
T
C
C
T
T
C
C
G
C
T
T
G
A
A
C
T
C
C
A
C
C
A
C
G
G
C
G
C
T
G
G
C
G
G
T
G
T
C
G
T
0.007828
0.009785
0.02544
0.003914
0.029354
0.048924
0.037182
0.013699
0.019569
0.037182
0.054795
0
0.001957
0.007828
0.013699
0.058708
0.046967
0.046967
0.062622
0.058708
0.037182
0.078278
0.009785
0.043053
0.023483
0.048924
0.039139
0.060665
0.048924
0.011742
0.001957
0.011742
1
9,825
C
C
A
C
T
C
A
C
A
C
C
T
G
C
C
T
G
T
T
G
G
G
G
A
G
C
C
C
A
G
G
C
C
G
C
C
A
C
A
C
T
C
C
T
C
A
C
A
C
T
C
C
A
G
C
C
G
T
C
T
C
T
T
G
C
A
0.007828
0.007828
0.023483
0.001957
0.035225
0.029354
0.009785
0.019569
0.023483
0.054795
0.072407
0.001957
0.011742
0.019569
0.021526
0.048924
0.093933
0.066536
0.09002
0.021526
0.007828
0.015656
0.005871
0.046967
0.009785
0.027397
0.064579
0.084149
0.046967
0.009785
0.001957
0.017613
1
9,826
A
G
C
C
C
C
G
G
G
G
G
A
T
T
A
A
A
G
C
T
G
G
C
T
A
T
G
G
C
A
C
C
T
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
C
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.04501
0.066536
0.009785
0.005871
0.021526
0.023483
0.041096
0.068493
0.074364
0.113503
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.04501
0.005871
0.011742
0.021526
1
9,827
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
C
A
G
G
T
G
C
C
A
T
A
G
C
C
A
G
C
T
T
T
A
A
T
C
C
C
C
C
G
G
G
G
C
T
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.04501
0.066536
0.011742
0.005871
0.021526
0.023483
0.041096
0.068493
0.074364
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.04501
0.005871
0.011742
0.021526
1
9,828
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
C
A
G
G
T
G
C
C
A
T
A
G
C
C
A
G
C
T
T
T
A
A
T
C
C
C
C
C
G
G
G
G
C
G
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.04501
0.066536
0.011742
0.005871
0.021526
0.023483
0.041096
0.068493
0.074364
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.04501
0.005871
0.011742
0.021526
1
9,829
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
C
A
G
G
T
G
C
C
A
T
A
G
C
C
A
G
C
T
T
T
A
A
T
C
C
C
C
C
G
G
G
G
C
A
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.04501
0.066536
0.011742
0.005871
0.021526
0.023483
0.041096
0.068493
0.074364
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.04501
0.005871
0.011742
0.021526
1
9,830
C
C
C
C
G
G
G
G
G
A
T
T
A
A
A
G
C
T
G
G
C
T
A
T
G
G
C
A
C
C
T
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
G
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.04501
0.066536
0.011742
0.005871
0.023483
0.023483
0.041096
0.068493
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.04501
0.005871
0.011742
0.021526
1
9,831
G
G
G
G
G
A
T
T
A
A
A
G
C
T
G
G
C
T
A
T
G
G
C
A
C
C
T
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
A
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.04501
0.066536
0.011742
0.007828
0.021526
0.023483
0.041096
0.068493
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.080235
0.04501
0.005871
0.011742
0.023483
1
9,832
G
G
G
G
G
A
T
T
A
A
A
G
C
T
G
G
C
T
A
T
G
G
C
A
C
C
T
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
G
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.04501
0.066536
0.011742
0.007828
0.021526
0.023483
0.041096
0.068493
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.080235
0.04501
0.005871
0.011742
0.023483
1
9,833
G
C
T
C
G
C
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
C
A
G
G
T
G
C
C
A
T
A
G
C
C
A
G
C
T
T
T
A
A
T
C
C
C
C
T
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.043053
0.066536
0.011742
0.007828
0.021526
0.023483
0.041096
0.068493
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.080235
0.046967
0.005871
0.011742
0.023483
1
9,834
G
C
T
C
G
C
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
C
A
G
G
T
G
C
C
A
T
A
G
C
C
A
G
C
T
T
T
A
A
T
C
C
C
C
A
0.011742
0.015656
0.033268
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.043053
0.066536
0.011742
0.007828
0.021526
0.023483
0.041096
0.068493
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.080235
0.046967
0.005871
0.011742
0.023483
1
9,835
G
G
G
A
T
T
A
A
A
G
C
T
G
G
C
T
A
T
G
G
C
A
C
C
T
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
C
C
G
0.011742
0.015656
0.031311
0.009785
0.02544
0.027397
0.005871
0.02544
0.027397
0.043053
0.066536
0.011742
0.007828
0.021526
0.023483
0.041096
0.068493
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.023483
0.033268
0.080235
0.046967
0.005871
0.011742
0.023483
1
9,836
G
C
A
C
C
T
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
C
C
C
G
A
A
G
A
C
A
T
C
C
A
G
G
G
T
G
A
G
A
0.013699
0.017613
0.031311
0.009785
0.02544
0.02544
0.005871
0.02544
0.029354
0.04501
0.066536
0.011742
0.007828
0.021526
0.023483
0.037182
0.07045
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.046967
0.005871
0.011742
0.019569
1
9,837
G
C
A
C
C
T
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
C
C
C
G
A
A
G
A
C
A
T
C
C
A
G
G
G
T
G
A
G
C
0.013699
0.017613
0.031311
0.009785
0.02544
0.02544
0.005871
0.02544
0.029354
0.04501
0.066536
0.011742
0.007828
0.021526
0.023483
0.037182
0.07045
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.046967
0.005871
0.011742
0.019569
1
9,838
G
C
A
C
C
T
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
C
C
C
G
A
A
G
A
C
A
T
C
C
A
G
G
G
T
G
A
G
G
0.013699
0.017613
0.031311
0.009785
0.02544
0.02544
0.005871
0.02544
0.029354
0.04501
0.066536
0.011742
0.007828
0.021526
0.023483
0.037182
0.07045
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.046967
0.005871
0.011742
0.019569
1
9,839
A
C
T
C
A
C
C
C
T
G
G
A
T
G
T
C
T
T
C
G
G
G
C
T
C
G
C
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
C
A
G
G
T
G
T
0.013699
0.017613
0.033268
0.009785
0.02544
0.02544
0.005871
0.02544
0.029354
0.04501
0.066536
0.011742
0.007828
0.021526
0.021526
0.037182
0.07045
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.046967
0.005871
0.011742
0.019569
1
9,840
A
C
T
C
A
C
C
C
T
G
G
A
T
G
T
C
T
T
C
G
G
G
C
T
C
G
C
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
C
A
G
G
T
G
G
0.013699
0.017613
0.033268
0.009785
0.02544
0.02544
0.005871
0.02544
0.029354
0.04501
0.066536
0.011742
0.007828
0.021526
0.021526
0.037182
0.07045
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.046967
0.005871
0.011742
0.019569
1
9,841
A
C
T
C
A
C
C
C
T
G
G
A
T
G
T
C
T
T
C
G
G
G
C
T
C
G
C
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
C
A
G
G
T
G
A
0.013699
0.017613
0.033268
0.009785
0.02544
0.02544
0.005871
0.02544
0.029354
0.04501
0.066536
0.011742
0.007828
0.021526
0.021526
0.037182
0.07045
0.072407
0.111546
0.015656
0.009785
0.015656
0.009785
0.052838
0.023483
0.021526
0.033268
0.082192
0.046967
0.005871
0.011742
0.019569
1
9,842
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
C
C
C
G
A
A
G
A
C
A
T
C
C
A
G
G
G
T
G
A
G
T
G
G
G
T
G
A
0.013699
0.017613
0.031311
0.009785
0.02544
0.027397
0.005871
0.02544
0.029354
0.043053
0.064579
0.011742
0.007828
0.021526
0.021526
0.039139
0.07045
0.074364
0.109589
0.015656
0.009785
0.015656
0.009785
0.052838
0.02544
0.021526
0.033268
0.080235
0.048924
0.005871
0.011742
0.019569
1
9,843
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
C
C
C
G
A
A
G
A
C
A
T
C
C
A
G
G
G
T
G
A
G
T
G
G
G
T
G
C
0.013699
0.017613
0.031311
0.009785
0.02544
0.027397
0.005871
0.02544
0.029354
0.043053
0.064579
0.011742
0.007828
0.021526
0.021526
0.039139
0.07045
0.074364
0.109589
0.015656
0.009785
0.015656
0.009785
0.052838
0.02544
0.021526
0.033268
0.080235
0.048924
0.005871
0.011742
0.019569
1
9,844
G
C
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
C
C
C
G
A
A
G
A
C
A
T
C
C
A
G
G
G
T
G
A
G
T
G
G
G
T
G
G
0.013699
0.017613
0.031311
0.009785
0.02544
0.027397
0.005871
0.02544
0.029354
0.043053
0.064579
0.011742
0.007828
0.021526
0.021526
0.039139
0.07045
0.074364
0.109589
0.015656
0.009785
0.015656
0.009785
0.052838
0.02544
0.021526
0.033268
0.080235
0.048924
0.005871
0.011742
0.019569
1
9,845
C
C
A
C
C
C
A
C
T
C
A
C
C
C
T
G
G
A
T
G
T
C
T
T
C
G
G
G
C
T
C
G
C
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
T
0.013699
0.017613
0.031311
0.009785
0.02544
0.027397
0.005871
0.02544
0.029354
0.043053
0.064579
0.011742
0.007828
0.021526
0.021526
0.039139
0.068493
0.076321
0.109589
0.015656
0.009785
0.015656
0.009785
0.052838
0.02544
0.021526
0.033268
0.080235
0.048924
0.005871
0.011742
0.019569
1
9,846
C
C
A
C
C
C
A
C
T
C
A
C
C
C
T
G
G
A
T
G
T
C
T
T
C
G
G
G
C
T
C
G
C
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
G
0.013699
0.017613
0.031311
0.009785
0.02544
0.027397
0.005871
0.02544
0.029354
0.043053
0.064579
0.011742
0.007828
0.021526
0.021526
0.039139
0.068493
0.076321
0.109589
0.015656
0.009785
0.015656
0.009785
0.052838
0.02544
0.021526
0.033268
0.080235
0.048924
0.005871
0.011742
0.019569
1
9,847
C
C
A
C
C
C
A
C
T
C
A
C
C
C
T
G
G
A
T
G
T
C
T
T
C
G
G
G
C
T
C
G
C
A
G
A
A
G
C
A
C
T
T
C
T
C
C
T
C
C
T
C
A
G
G
G
A
A
G
C
A
G
T
T
G
A
0.013699
0.017613
0.031311
0.009785
0.02544
0.027397
0.005871
0.02544
0.029354
0.043053
0.064579
0.011742
0.007828
0.021526
0.021526
0.039139
0.068493
0.076321
0.109589
0.015656
0.009785
0.015656
0.009785
0.052838
0.02544
0.021526
0.033268
0.080235
0.048924
0.005871
0.011742
0.019569
1
9,848
A
A
C
T
G
C
T
T
C
C
C
T
G
A
G
G
A
G
G
A
G
A
A
G
T
G
C
T
T
C
T
G
C
G
A
G
C
C
C
G
A
A
G
A
C
A
T
C
C
A
G
G
G
T
G
A
G
T
G
G
G
T
G
G
C
G
0.013699
0.017613
0.031311
0.009785
0.02544
0.027397
0.005871
0.02544
0.029354
0.043053
0.064579
0.011742
0.007828
0.021526
0.023483
0.039139
0.068493
0.076321
0.109589
0.015656
0.009785
0.015656
0.009785
0.052838
0.02544
0.021526
0.031311
0.080235
0.048924
0.005871
0.011742
0.019569
1
9,849
G
C
C
T
C
A
C
A
C
C
A
C
C
C
C
C
A
C
C
C
A
C
A
G
A
T
C
C
A
C
T
G
T
G
C
G
A
C
G
A
G
C
T
G
T
G
C
C
G
C
A
C
G
G
T
G
A
T
C
G
C
A
G
C
C
C
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.050881
0.054795
0.003914
0.02544
0.033268
0.011742
0.052838
0.068493
0.064579
0.043053
0.037182
0.017613
0.023483
0.009785
0.064579
0.021526
0.021526
0.046967
0.07045
0.04501
0.017613
0.003914
0.02544
1
9,850
C
G
G
C
T
G
C
G
A
T
C
A
C
C
G
T
G
C
G
G
C
A
C
A
G
C
T
C
G
T
C
G
C
A
C
A
G
T
G
G
A
T
C
T
G
T
G
G
G
T
G
G
G
G
G
T
G
G
T
G
T
G
A
G
G
T
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.050881
0.054795
0.003914
0.02544
0.033268
0.011742
0.052838
0.066536
0.064579
0.043053
0.037182
0.017613
0.023483
0.009785
0.064579
0.021526
0.023483
0.046967
0.07045
0.04501
0.017613
0.003914
0.02544
1
9,851
A
G
C
G
G
C
T
G
C
G
A
T
C
A
C
C
G
T
G
C
G
G
C
A
C
A
G
C
T
C
G
T
C
G
C
A
C
A
G
T
G
G
A
T
C
T
G
T
G
G
G
T
G
G
G
G
G
T
G
G
T
G
T
G
A
A
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.050881
0.052838
0.003914
0.02544
0.033268
0.011742
0.052838
0.066536
0.064579
0.04501
0.037182
0.017613
0.023483
0.009785
0.064579
0.021526
0.023483
0.046967
0.068493
0.046967
0.017613
0.003914
0.02544
1
9,852
C
C
C
C
A
C
C
C
A
C
A
G
A
T
C
C
A
C
T
G
T
G
C
G
A
C
G
A
G
C
T
G
T
G
C
C
G
C
A
C
G
G
T
G
A
T
C
G
C
A
G
C
C
G
C
T
G
T
C
C
T
C
T
T
C
A
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.04501
0.054795
0.003914
0.02544
0.033268
0.011742
0.052838
0.064579
0.064579
0.048924
0.039139
0.017613
0.02544
0.009785
0.062622
0.021526
0.023483
0.048924
0.068493
0.046967
0.017613
0.003914
0.023483
1
9,853
C
C
C
C
A
C
C
C
A
C
A
G
A
T
C
C
A
C
T
G
T
G
C
G
A
C
G
A
G
C
T
G
T
G
C
C
G
C
A
C
G
G
T
G
A
T
C
G
C
A
G
C
C
G
C
T
G
T
C
C
T
C
T
T
C
C
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.04501
0.054795
0.003914
0.02544
0.033268
0.011742
0.052838
0.064579
0.064579
0.048924
0.039139
0.017613
0.02544
0.009785
0.062622
0.021526
0.023483
0.048924
0.068493
0.046967
0.017613
0.003914
0.023483
1
9,854
C
C
C
C
A
C
C
C
A
C
A
G
A
T
C
C
A
C
T
G
T
G
C
G
A
C
G
A
G
C
T
G
T
G
C
C
G
C
A
C
G
G
T
G
A
T
C
G
C
A
G
C
C
G
C
T
G
T
C
C
T
C
T
T
C
G
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.04501
0.054795
0.003914
0.02544
0.033268
0.011742
0.052838
0.064579
0.064579
0.048924
0.039139
0.017613
0.02544
0.009785
0.062622
0.021526
0.023483
0.048924
0.068493
0.046967
0.017613
0.003914
0.023483
1
9,855
A
G
A
A
G
A
G
G
A
C
A
G
C
G
G
C
T
G
C
G
A
T
C
A
C
C
G
T
G
C
G
G
C
A
C
A
G
C
T
C
G
T
C
G
C
A
C
A
G
T
G
G
A
T
C
T
G
T
G
G
G
T
G
G
G
T
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.04501
0.052838
0.003914
0.02544
0.033268
0.011742
0.052838
0.066536
0.064579
0.048924
0.039139
0.017613
0.02544
0.009785
0.062622
0.021526
0.023483
0.048924
0.068493
0.046967
0.017613
0.003914
0.023483
1
9,856
A
G
A
A
G
A
G
G
A
C
A
G
C
G
G
C
T
G
C
G
A
T
C
A
C
C
G
T
G
C
G
G
C
A
C
A
G
C
T
C
G
T
C
G
C
A
C
A
G
T
G
G
A
T
C
T
G
T
G
G
G
T
G
G
G
G
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.04501
0.052838
0.003914
0.02544
0.033268
0.011742
0.052838
0.066536
0.064579
0.048924
0.039139
0.017613
0.02544
0.009785
0.062622
0.021526
0.023483
0.048924
0.068493
0.046967
0.017613
0.003914
0.023483
1
9,857
A
G
A
A
G
A
G
G
A
C
A
G
C
G
G
C
T
G
C
G
A
T
C
A
C
C
G
T
G
C
G
G
C
A
C
A
G
C
T
C
G
T
C
G
C
A
C
A
G
T
G
G
A
T
C
T
G
T
G
G
G
T
G
G
G
A
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.04501
0.052838
0.003914
0.02544
0.033268
0.011742
0.052838
0.066536
0.064579
0.048924
0.039139
0.017613
0.02544
0.009785
0.062622
0.021526
0.023483
0.048924
0.068493
0.046967
0.017613
0.003914
0.023483
1
9,858
C
C
A
C
C
C
A
C
A
G
A
T
C
C
A
C
T
G
T
G
C
G
A
C
G
A
G
C
T
G
T
G
C
C
G
C
A
C
G
G
T
G
A
T
C
G
C
A
G
C
C
G
C
T
G
T
C
C
T
C
T
T
C
T
C
G
0.003914
0.005871
0.027397
0.003914
0.027397
0.041096
0.011742
0.019569
0.04501
0.04501
0.054795
0.003914
0.02544
0.033268
0.011742
0.052838
0.066536
0.064579
0.048924
0.039139
0.017613
0.02544
0.009785
0.060665
0.021526
0.023483
0.048924
0.068493
0.046967
0.017613
0.003914
0.023483
1
9,859
G
T
G
C
G
A
C
G
A
G
C
T
G
T
G
C
C
G
C
A
C
G
G
T
G
A
T
C
G
C
A
G
C
C
G
C
T
G
T
C
C
T
C
T
T
C
T
C
C
T
T
C
A
T
C
G
T
C
T
C
G
G
T
G
C
G
0.003914
0.005871
0.029354
0.003914
0.02544
0.041096
0.011742
0.019569
0.039139
0.043053
0.056751
0.003914
0.029354
0.033268
0.011742
0.052838
0.064579
0.064579
0.056751
0.039139
0.017613
0.02544
0.009785
0.054795
0.023483
0.021526
0.050881
0.068493
0.048924
0.017613
0.003914
0.021526
1
9,860
A
G
G
A
C
G
T
T
G
A
A
C
T
C
T
G
A
C
A
G
C
A
G
G
T
C
T
C
G
C
A
G
C
T
C
A
C
T
C
G
G
G
G
A
G
G
C
G
T
T
C
T
C
T
G
A
A
A
T
G
C
A
G
C
A
G
0.019569
0.021526
0.035225
0.005871
0.029354
0.031311
0.009785
0.011742
0.039139
0.058708
0.074364
0.005871
0.023483
0.031311
0.02544
0.027397
0.09002
0.054795
0.058708
0.005871
0.011742
0.007828
0.005871
0.050881
0.035225
0.023483
0.054795
0.054795
0.048924
0.009785
0.001957
0.035225
1
9,861
G
C
C
C
C
G
C
A
G
G
G
A
G
C
C
G
T
A
T
T
T
G
G
C
G
T
A
C
T
C
C
A
C
G
A
T
G
A
G
G
A
G
G
A
G
C
G
G
G
C
C
T
G
G
G
G
G
C
G
G
A
G
A
G
A
G
0.007828
0.003914
0.023483
0.005871
0.011742
0.037182
0.011742
0.015656
0.035225
0.052838
0.066536
0.007828
0.015656
0.021526
0.017613
0.04501
0.074364
0.064579
0.082192
0.033268
0.009785
0.031311
0.001957
0.068493
0.013699
0.015656
0.056751
0.086106
0.041096
0.011742
0.001957
0.027397
1
9,862
G
C
C
C
C
G
C
A
G
G
G
A
G
C
C
G
T
A
T
T
T
G
G
C
G
T
A
C
T
C
C
A
C
G
A
T
G
A
G
G
A
G
G
A
G
C
G
G
G
C
C
T
G
G
G
G
G
C
G
G
A
G
A
G
A
A
0.007828
0.003914
0.023483
0.005871
0.011742
0.037182
0.011742
0.015656
0.035225
0.052838
0.066536
0.007828
0.015656
0.021526
0.017613
0.04501
0.074364
0.064579
0.082192
0.033268
0.009785
0.031311
0.001957
0.068493
0.013699
0.015656
0.056751
0.086106
0.041096
0.011742
0.001957
0.027397
1
9,863
T
C
C
T
G
G
T
A
G
C
T
G
A
G
G
G
G
C
G
G
A
A
G
A
T
G
A
A
G
A
T
T
T
C
G
G
A
T
T
T
C
G
G
C
T
T
G
T
C
C
C
G
A
G
A
T
G
T
T
T
A
T
G
A
A
G
0.02544
0.007828
0.027397
0.015656
0.021526
0.041096
0.013699
0.015656
0.029354
0.048924
0.054795
0.011742
0.02544
0.033268
0.011742
0.048924
0.056751
0.064579
0.074364
0.031311
0.015656
0.013699
0.021526
0.041096
0.029354
0.027397
0.029354
0.066536
0.043053
0.007828
0.009785
0.035225
1
9,864
C
C
T
G
C
G
A
A
G
G
G
A
C
C
C
C
A
C
T
C
A
G
G
T
T
A
A
G
G
C
T
G
C
G
C
A
G
G
A
A
A
T
C
C
A
C
C
T
T
C
A
C
G
T
T
C
T
C
C
A
G
A
A
A
C
A
0.015656
0.017613
0.029354
0.011742
0.039139
0.039139
0.017613
0.019569
0.021526
0.050881
0.060665
0.003914
0.011742
0.021526
0.017613
0.050881
0.080235
0.062622
0.068493
0.015656
0.009785
0.035225
0.009785
0.033268
0.027397
0.029354
0.046967
0.050881
0.048924
0.017613
0.013699
0.021526
1
9,865
G
G
T
C
C
C
T
T
C
G
C
A
G
G
A
C
A
A
A
A
C
C
A
G
G
G
T
G
G
A
G
C
C
G
C
C
G
C
A
G
T
A
C
A
T
G
A
T
T
G
A
C
C
T
G
T
A
C
A
A
C
A
G
G
T
T
0.029354
0.019569
0.035225
0.021526
0.037182
0.039139
0.015656
0.021526
0.017613
0.054795
0.056751
0.007828
0.009785
0.023483
0.017613
0.046967
0.074364
0.062622
0.064579
0.009785
0.009785
0.027397
0.011742
0.029354
0.033268
0.027397
0.039139
0.043053
0.046967
0.019569
0.023483
0.023483
1
9,866
G
C
A
C
T
A
A
G
G
C
G
G
A
G
G
T
G
C
C
C
A
T
G
A
G
A
T
T
C
C
C
C
C
A
C
A
C
G
T
G
G
G
C
C
A
C
C
A
G
G
A
A
C
T
C
C
C
C
C
A
T
C
A
T
G
G
0.003914
0.013699
0.015656
0.005871
0.027397
0.050881
0.017613
0.015656
0.031311
0.035225
0.068493
0.003914
0.027397
0.029354
0.013699
0.060665
0.066536
0.07045
0.07045
0.029354
0.009785
0.013699
0.013699
0.054795
0.017613
0.02544
0.048924
0.056751
0.060665
0.013699
0.003914
0.023483
1
9,867
T
G
C
C
A
A
G
G
A
C
C
G
C
A
T
T
C
C
T
G
G
A
A
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T
G
T
G
C
C
C
A
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G
C
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G
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G
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C
A
A
G
A
G
A
G
A
C
C
T
G
G
C
T
G
A
A
C
A
0.027397
0.027397
0.027397
0.019569
0.02544
0.048924
0.011742
0.02544
0.048924
0.035225
0.041096
0.011742
0.015656
0.031311
0.035225
0.04501
0.062622
0.052838
0.046967
0.031311
0.003914
0.011742
0.013699
0.046967
0.029354
0.031311
0.056751
0.046967
0.031311
0.007828
0.009785
0.039139
1
9,868
G
A
A
G
C
A
C
T
G
A
C
C
C
C
T
G
G
C
C
A
C
T
G
A
C
C
T
C
A
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G
T
C
G
A
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G
A
T
C
A
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G
G
C
A
T
C
C
G
T
G
T
G
C
A
T
G
A
T
C
T
T
C
T
T
0.027397
0.017613
0.035225
0.013699
0.033268
0.023483
0.009785
0.027397
0.027397
0.058708
0.060665
0.005871
0.031311
0.033268
0.029354
0.037182
0.082192
0.054795
0.046967
0.005871
0.005871
0.005871
0.021526
0.037182
0.031311
0.029354
0.046967
0.048924
0.048924
0.009785
0.005871
0.046967
1
9,869
A
A
T
C
T
T
C
A
A
G
C
A
G
T
T
T
T
T
G
A
C
A
A
A
T
A
G
A
G
T
G
C
T
A
A
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A
C
C
C
A
A
A
A
C
A
A
A
G
G
C
G
G
T
T
T
T
T
C
A
A
A
T
C
0.105675
0.02544
0.039139
0.080235
0.033268
0.019569
0
0.027397
0.046967
0.031311
0.023483
0.058708
0.041096
0.031311
0.046967
0.015656
0.039139
0.02544
0.013699
0.001957
0
0.001957
0.029354
0.021526
0.031311
0.013699
0.035225
0.009785
0.021526
0.02544
0.064579
0.039139
1
9,870
A
A
A
T
G
A
T
T
G
T
T
G
T
T
G
A
G
T
C
T
T
T
G
T
T
G
A
A
A
A
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A
T
G
G
C
A
C
A
A
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C
A
G
G
G
T
C
A
G
C
G
A
G
T
A
T
T
G
C
T
G
T
T
T
A
0.076321
0.035225
0.050881
0.031311
0.037182
0.031311
0.005871
0.041096
0.064579
0.021526
0.029354
0.015656
0.039139
0.031311
0.041096
0.027397
0.04501
0.033268
0.023483
0.007828
0.003914
0.001957
0.027397
0.033268
0.046967
0.027397
0.023483
0.015656
0.023483
0.02544
0.029354
0.052838
1
9,871
C
T
G
T
T
C
A
T
T
T
T
T
A
T
C
T
G
G
C
A
A
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A
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G
C
T
C
A
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G
A
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A
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C
T
G
A
C
T
T
C
A
T
T
C
T
C
C
G
C
A
G
T
A
G
G
T
C
0.072407
0.027397
0.052838
0.035225
0.039139
0.019569
0.007828
0.033268
0.052838
0.031311
0.041096
0.035225
0.02544
0.041096
0.02544
0.027397
0.043053
0.031311
0.013699
0.005871
0.003914
0.009785
0.023483
0.039139
0.04501
0.023483
0.031311
0.017613
0.041096
0.023483
0.04501
0.035225
1
9,872
T
T
C
C
T
T
T
C
C
T
C
A
A
A
T
A
G
T
T
T
C
G
C
A
C
C
C
C
T
C
A
T
C
G
G
A
T
C
A
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C
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G
T
C
T
G
G
C
T
C
A
C
C
G
A
T
G
C
A
A
A
A
T
T
0.09589
0.021526
0.033268
0.080235
0.029354
0.021526
0.007828
0.02544
0.031311
0.02544
0.029354
0.04501
0.029354
0.048924
0.035225
0.021526
0.019569
0.02544
0.027397
0.011742
0.011742
0.007828
0.02544
0.035225
0.039139
0.009785
0.033268
0.011742
0.033268
0.031311
0.058708
0.037182
1
9,873
G
G
C
A
G
G
A
G
G
A
A
T
T
C
T
G
G
G
A
G
A
T
G
A
A
A
T
G
G
G
A
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T
G
G
G
C
A
A
G
A
C
C
A
T
C
C
A
G
A
T
A
A
T
T
G
C
C
T
T
C
T
T
G
G
G
0.054795
0.017613
0.02544
0.074364
0.052838
0.02544
0.003914
0.021526
0.04501
0.02544
0.035225
0.035225
0.033268
0.04501
0.04501
0.027397
0.052838
0.041096
0.019569
0.001957
0.003914
0.001957
0.017613
0.031311
0.035225
0.027397
0.035225
0.019569
0.033268
0.031311
0.037182
0.043053
1
9,874
T
T
C
C
C
C
G
A
A
T
A
A
A
T
T
G
T
T
T
G
C
A
C
C
C
G
T
G
A
C
G
A
C
C
A
A
A
A
T
A
A
G
G
A
A
C
C
A
T
G
A
A
T
T
C
A
T
C
A
A
A
G
C
T
G
T
0.082192
0.039139
0.029354
0.060665
0.041096
0.037182
0.013699
0.029354
0.023483
0.019569
0.021526
0.041096
0.013699
0.048924
0.054795
0.037182
0.031311
0.043053
0.017613
0.013699
0.009785
0.005871
0.017613
0.017613
0.04501
0.02544
0.043053
0.017613
0.023483
0.021526
0.029354
0.04501
1
9,875
G
A
A
T
G
A
C
A
T
G
T
A
T
C
T
C
A
A
C
A
A
C
C
G
C
C
T
G
G
C
C
C
T
G
C
C
T
G
T
C
A
A
C
T
C
C
A
G
C
C
C
T
G
C
C
G
T
G
A
T
C
T
T
T
G
C
0.021526
0.011742
0.035225
0.017613
0.033268
0.035225
0.007828
0.021526
0.021526
0.046967
0.066536
0.013699
0.015656
0.027397
0.02544
0.043053
0.072407
0.056751
0.068493
0.021526
0.015656
0.001957
0.007828
0.043053
0.027397
0.033268
0.039139
0.064579
0.04501
0.009785
0.011742
0.037182
1
9,876
A
T
G
A
C
A
T
G
T
A
T
C
T
C
A
A
C
A
A
C
C
G
C
C
T
G
G
C
C
C
T
G
C
C
T
G
T
C
A
A
C
T
C
C
A
G
C
C
C
T
G
C
C
G
T
G
A
T
C
T
T
T
G
C
T
G
0.021526
0.011742
0.035225
0.017613
0.033268
0.035225
0.007828
0.021526
0.021526
0.046967
0.066536
0.013699
0.015656
0.027397
0.02544
0.043053
0.07045
0.054795
0.068493
0.021526
0.015656
0.001957
0.007828
0.043053
0.027397
0.035225
0.039139
0.064579
0.04501
0.009785
0.011742
0.039139
1
9,877
C
A
G
C
A
G
C
A
T
C
A
T
G
C
C
G
G
A
G
C
C
T
G
A
G
C
A
C
G
T
C
A
T
C
G
T
A
G
C
C
T
G
C
T
G
C
A
A
T
C
A
G
G
T
A
A
G
C
A
A
C
C
C
C
T
C
0.011742
0.013699
0.033268
0.015656
0.02544
0.02544
0.017613
0.033268
0.035225
0.04501
0.054795
0.013699
0.013699
0.039139
0.02544
0.043053
0.060665
0.056751
0.062622
0.015656
0.005871
0.003914
0.009785
0.066536
0.029354
0.027397
0.039139
0.052838
0.048924
0.017613
0.009785
0.046967
1
9,878
G
G
A
C
G
A
G
C
G
T
T
T
G
C
C
T
C
C
A
A
T
T
G
G
C
C
T
G
C
T
G
A
C
G
T
C
T
G
A
C
G
G
G
A
G
G
A
G
C
G
A
G
T
G
G
G
C
C
G
A
G
G
C
C
A
T
0.02544
0.027397
0.031311
0.013699
0.035225
0.027397
0.023483
0.023483
0.023483
0.037182
0.054795
0.005871
0.021526
0.037182
0.039139
0.048924
0.052838
0.066536
0.054795
0.017613
0.015656
0.009785
0.007828
0.04501
0.02544
0.027397
0.033268
0.076321
0.035225
0.005871
0.007828
0.043053
1
9,879
C
T
G
G
A
C
G
G
C
T
T
A
C
C
T
G
C
A
G
G
G
A
C
T
T
G
T
C
G
T
A
C
C
A
G
C
G
A
T
T
G
G
C
C
C
C
G
T
T
C
T
T
G
C
T
G
T
A
G
C
C
T
C
C
G
G
0.001957
0.009785
0.023483
0.005871
0.037182
0.02544
0.015656
0.021526
0.043053
0.058708
0.062622
0.001957
0.015656
0.015656
0.023483
0.04501
0.093933
0.056751
0.056751
0.017613
0.009785
0.031311
0.009785
0.058708
0.013699
0.033268
0.056751
0.07045
0.041096
0.011742
0.003914
0.027397
1
9,880
C
T
C
C
C
C
G
G
A
A
A
T
T
C
A
A
G
G
C
C
A
C
T
T
A
G
C
C
T
C
C
T
C
G
G
C
A
G
A
A
A
A
A
C
T
T
C
A
A
C
G
G
T
A
A
G
G
A
T
A
A
C
C
G
A
T
0.046967
0.021526
0.035225
0.019569
0.015656
0.02544
0.013699
0.021526
0.039139
0.052838
0.058708
0.009785
0.019569
0.021526
0.029354
0.019569
0.052838
0.033268
0.066536
0.031311
0.011742
0.017613
0.019569
0.064579
0.029354
0.021526
0.046967
0.041096
0.056751
0.013699
0.015656
0.027397
1
9,881
A
A
A
C
T
T
A
T
A
G
A
C
A
A
T
G
A
A
G
T
C
A
A
G
G
T
T
C
T
T
T
A
C
T
A
T
T
C
T
G
A
G
G
A
A
G
A
A
A
A
A
G
A
A
A
A
G
A
T
G
T
T
T
T
T
A
0.035225
0.017613
0.043053
0.011742
0.037182
0.029354
0.007828
0.035225
0.050881
0.033268
0.064579
0.015656
0.013699
0.041096
0.017613
0.033268
0.07045
0.035225
0.041096
0.009785
0.001957
0.003914
0.033268
0.037182
0.04501
0.043053
0.043053
0.037182
0.043053
0.015656
0.009785
0.043053
1
9,882
C
A
T
C
T
C
G
G
G
C
A
G
C
T
C
C
T
T
G
C
A
C
A
T
G
G
C
C
C
G
G
G
C
C
A
G
C
T
C
C
C
G
C
A
G
T
G
C
C
A
G
C
A
G
G
T
G
G
T
T
G
T
C
A
A
T
0.023483
0.027397
0.027397
0.013699
0.039139
0.02544
0.005871
0.035225
0.035225
0.054795
0.043053
0.007828
0.02544
0.04501
0.031311
0.033268
0.07045
0.04501
0.033268
0.02544
0.003914
0.011742
0.029354
0.041096
0.02544
0.019569
0.054795
0.054795
0.033268
0.02544
0.011742
0.041096
1
9,883
C
C
C
C
C
A
G
C
C
A
G
A
G
A
C
C
A
T
C
C
T
T
T
T
C
T
G
C
A
T
C
T
C
T
A
G
C
T
T
T
C
A
C
A
G
C
T
G
C
A
A
A
G
A
G
A
C
T
T
C
T
T
C
T
A
G
0.041096
0.02544
0.039139
0.015656
0.029354
0.039139
0.005871
0.021526
0.050881
0.060665
0.04501
0.005871
0.015656
0.029354
0.041096
0.029354
0.072407
0.066536
0.043053
0.007828
0.005871
0.003914
0.023483
0.043053
0.031311
0.033268
0.050881
0.041096
0.041096
0.007828
0.007828
0.02544
1
9,884
T
T
A
T
C
T
T
C
A
C
A
C
C
T
A
A
A
T
C
T
C
T
G
C
T
G
A
G
G
C
A
C
C
C
A
G
A
G
G
C
C
A
A
G
T
C
C
A
G
C
T
T
T
G
A
C
C
A
A
A
T
G
G
T
A
G
0.007828
0.013699
0.023483
0.015656
0.02544
0.04501
0.015656
0.021526
0.02544
0.056751
0.052838
0.007828
0.015656
0.023483
0.029354
0.050881
0.084149
0.084149
0.054795
0.021526
0.005871
0.011742
0.015656
0.033268
0.019569
0.027397
0.052838
0.074364
0.037182
0.015656
0.003914
0.027397
1
9,885
G
G
T
C
A
A
C
C
T
C
C
T
G
G
T
C
A
T
G
G
A
G
A
A
C
A
T
G
G
T
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C
C
G
G
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G
A
C
T
G
C
A
G
A
G
A
C
A
C
A
G
A
C
C
G
G
G
G
C
A
G
G
G
A
T
0.005871
0.013699
0.011742
0.001957
0.039139
0.041096
0.015656
0.007828
0.033268
0.035225
0.084149
0.001957
0.011742
0.027397
0.011742
0.048924
0.091977
0.066536
0.09002
0.023483
0.003914
0.011742
0.007828
0.048924
0.013699
0.035225
0.056751
0.076321
0.054795
0.007828
0.001957
0.017613
1
9,886
T
G
C
G
C
A
A
G
G
C
A
C
A
G
C
A
G
G
G
A
G
G
G
G
G
A
C
C
C
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C
C
T
G
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C
A
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C
C
C
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A
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A
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G
A
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A
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C
T
C
A
A
T
C
C
C
0.019569
0.017613
0.02544
0.019569
0.027397
0.037182
0.001957
0.015656
0.048924
0.029354
0.07045
0.001957
0.029354
0.035225
0.023483
0.031311
0.066536
0.060665
0.080235
0.015656
0.007828
0.009785
0.003914
0.068493
0.035225
0.027397
0.027397
0.046967
0.064579
0.005871
0.003914
0.041096
1
9,887
T
C
T
C
C
A
G
C
G
A
G
G
A
G
A
A
G
C
G
G
A
C
C
C
T
G
C
T
G
G
C
C
C
G
G
C
T
A
G
T
G
C
G
C
T
C
C
A
T
G
A
G
G
T
T
G
G
C
A
C
C
A
C
C
T
T
0.015656
0.023483
0.027397
0.003914
0.029354
0.033268
0.009785
0.02544
0.04501
0.048924
0.066536
0.001957
0.017613
0.027397
0.027397
0.039139
0.072407
0.066536
0.046967
0.017613
0.005871
0.009785
0.019569
0.066536
0.023483
0.029354
0.046967
0.056751
0.060665
0.005871
0.003914
0.02544
1
9,888
T
G
A
A
A
A
T
A
G
T
C
T
T
A
C
T
C
T
T
G
A
C
G
G
T
C
G
C
T
G
T
C
C
G
G
G
T
A
C
A
G
T
T
G
T
A
A
A
G
A
A
T
A
G
C
C
A
A
T
T
C
C
C
C
A
T
0.131115
0.037182
0.046967
0.076321
0.050881
0.019569
0.003914
0.027397
0.029354
0.015656
0.031311
0.050881
0.015656
0.041096
0.050881
0.017613
0.019569
0.017613
0.015656
0.005871
0.003914
0.005871
0.017613
0.017613
0.041096
0.015656
0.023483
0.013699
0.021526
0.031311
0.068493
0.035225
1
9,889
T
T
G
G
C
A
C
A
A
G
G
A
C
A
C
A
A
G
G
A
A
G
A
A
A
C
A
T
T
G
G
A
C
C
C
A
A
G
T
C
A
T
C
T
C
C
A
T
C
C
A
G
A
A
C
A
T
C
C
A
C
T
G
T
G
T
0.076321
0.039139
0.023483
0.04501
0.041096
0.035225
0.007828
0.037182
0.029354
0.011742
0.031311
0.054795
0.02544
0.041096
0.04501
0.041096
0.031311
0.054795
0.027397
0.011742
0.005871
0.001957
0.017613
0.037182
0.031311
0.017613
0.023483
0.02544
0.037182
0.023483
0.029354
0.039139
1
9,890
G
T
C
T
C
A
G
G
T
G
G
A
T
C
T
T
G
G
T
G
T
G
G
C
G
C
T
T
C
C
T
C
T
C
A
T
C
A
C
T
C
C
G
G
G
C
A
A
A
C
T
T
T
C
G
G
C
C
A
C
A
G
T
A
G
C
0.013699
0.009785
0.033268
0.001957
0.031311
0.041096
0.011742
0.02544
0.039139
0.046967
0.04501
0.007828
0.021526
0.015656
0.019569
0.056751
0.066536
0.043053
0.062622
0.050881
0.019569
0.031311
0.005871
0.050881
0.021526
0.029354
0.056751
0.056751
0.039139
0.013699
0.003914
0.027397
1