row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
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string
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string
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string
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string
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string
f_10_ref__22
string
f_11_ref__21
string
f_12_ref__20
string
f_13_ref__19
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_36_ref__4
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_46_ref__14
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
10,291
T
T
G
G
G
C
C
A
C
A
T
G
A
A
C
A
T
C
G
C
A
C
T
C
T
T
G
T
C
A
G
A
C
T
T
A
A
C
T
A
A
G
C
A
G
A
T
T
T
C
C
C
G
A
G
A
C
T
A
C
G
G
T
G
T
G
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1
10,292
A
G
T
C
T
C
A
G
T
G
G
A
T
T
C
C
C
A
C
T
T
T
A
G
C
C
A
T
C
T
T
G
C
C
T
G
G
A
T
A
A
A
T
A
C
A
C
C
A
A
G
A
A
A
G
G
T
A
T
G
G
C
A
T
T
G
0.103718
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1
10,293
T
C
A
C
C
A
G
C
T
C
C
C
G
C
G
G
G
G
G
T
A
C
A
T
C
T
C
C
A
T
T
C
C
G
G
T
G
A
T
A
C
A
C
G
A
G
C
A
G
A
A
C
G
T
T
A
C
C
C
G
G
C
C
A
G
A
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1
10,294
T
C
A
C
C
A
G
C
T
C
C
C
G
C
G
G
G
G
G
T
A
C
A
T
C
T
C
C
A
T
T
C
C
G
G
T
G
A
T
A
C
A
C
G
A
G
C
A
G
A
A
C
G
T
T
A
C
C
C
G
G
C
C
A
G
T
0.009785
0.005871
0.017613
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0.037182
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0.017613
0.029354
0.048924
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0.009785
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0.005871
0.029354
1
10,295
C
A
G
G
G
C
C
A
G
C
A
G
C
T
C
T
T
T
G
G
T
C
A
A
A
T
A
C
T
C
T
T
C
G
A
T
C
A
T
C
A
G
G
T
A
C
T
T
T
T
T
G
T
C
A
G
T
C
T
T
C
T
T
G
C
T
0.035225
0.017613
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0.080235
0.060665
0.052838
0.009785
0.011742
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0.041096
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0.041096
0.048924
0.050881
0.015656
0
0.033268
1
10,296
C
C
A
A
A
G
A
G
C
T
G
C
T
G
G
C
C
C
T
G
G
A
T
T
C
A
G
T
G
G
A
C
C
C
C
G
A
G
G
G
A
C
G
A
G
C
C
G
A
T
G
T
G
C
G
T
C
A
G
G
C
C
A
G
G
T
0.039139
0.017613
0.050881
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0.027397
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0.037182
0.04501
0.029354
0.04501
0.046967
0.043053
0.015656
0
0.033268
1
10,297
G
T
A
T
T
T
A
C
C
G
A
T
A
T
T
G
A
T
G
G
C
C
A
A
G
T
G
T
A
T
C
A
T
C
T
C
A
C
T
G
T
T
G
A
A
G
G
A
A
A
C
T
C
A
G
T
A
A
A
A
G
A
C
A
G
A
0.093933
0.04501
0.04501
0.052838
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0.011742
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0.027397
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0.007828
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0.02544
0.023483
0.037182
0.009785
0.023483
0.015656
0.027397
0.031311
0.07045
0.037182
1
10,298
C
T
G
T
G
T
T
A
C
T
G
C
C
A
T
C
G
A
C
T
T
A
C
A
T
T
G
G
T
G
G
T
C
T
T
T
T
T
G
T
A
A
T
A
G
T
C
T
A
T
A
T
T
G
T
T
G
A
T
A
T
C
T
C
T
A
0.084149
0.035225
0.031311
0.062622
0.043053
0.019569
0.003914
0.031311
0.048924
0.02544
0.015656
0.060665
0.02544
0.033268
0.039139
0.021526
0.041096
0.031311
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0.013699
0.011742
0.009785
0.027397
0.021526
0.050881
0.017613
0.023483
0.023483
0.017613
0.021526
0.039139
0.037182
1
10,299
C
T
G
T
G
T
T
A
C
T
G
C
C
A
T
C
G
A
C
T
T
A
C
A
T
T
G
G
T
G
G
T
C
T
T
T
T
T
G
T
A
A
T
A
G
T
C
T
A
T
A
T
T
G
T
T
G
A
T
A
T
C
T
C
T
G
0.084149
0.035225
0.031311
0.062622
0.043053
0.019569
0.003914
0.031311
0.048924
0.02544
0.015656
0.060665
0.02544
0.033268
0.039139
0.021526
0.041096
0.031311
0.031311
0.013699
0.011742
0.009785
0.027397
0.021526
0.050881
0.017613
0.023483
0.023483
0.017613
0.021526
0.039139
0.037182
1
10,300
T
T
T
G
T
A
A
T
A
G
T
C
T
A
T
A
T
T
G
T
T
G
A
T
A
T
C
T
C
T
G
G
C
G
A
G
T
C
C
A
A
A
G
T
C
T
G
C
T
A
T
T
T
T
C
A
T
C
A
C
A
T
T
G
T
T
0.080235
0.033268
0.029354
0.058708
0.04501
0.023483
0.003914
0.031311
0.04501
0.023483
0.015656
0.054795
0.021526
0.037182
0.037182
0.029354
0.039139
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0.033268
0.017613
0.011742
0.009785
0.023483
0.023483
0.046967
0.017613
0.02544
0.031311
0.015656
0.023483
0.037182
0.037182
1
10,301
A
T
T
G
T
T
T
T
C
T
G
T
T
A
C
C
A
A
A
A
C
A
T
T
T
C
T
G
G
C
T
G
C
T
A
A
A
T
C
T
C
G
A
T
G
A
A
T
A
C
A
C
T
G
A
A
A
T
C
A
A
G
A
A
A
T
0.07045
0.031311
0.033268
0.04501
0.039139
0.031311
0.003914
0.033268
0.043053
0.02544
0.021526
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0.02544
0.031311
0.037182
0.031311
0.046967
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0.019569
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0.011742
0.019569
0.023483
0.046967
0.021526
0.023483
0.033268
0.019569
0.023483
0.027397
0.039139
1
10,302
A
C
T
C
A
C
C
A
T
C
C
T
G
T
G
T
G
C
A
G
G
C
T
C
C
A
A
G
A
A
G
A
T
T
T
A
T
G
A
T
A
T
T
C
T
T
G
T
G
T
T
T
C
C
C
A
A
T
C
A
T
C
T
T
C
G
0.072407
0.027397
0.037182
0.04501
0.039139
0.015656
0.001957
0.027397
0.052838
0.017613
0.041096
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0.048924
0.050881
0.033268
0.031311
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0.041096
0.033268
0.001957
0.005871
0.001957
0.021526
0.031311
0.056751
0.011742
0.035225
0.027397
0.039139
0.013699
0.019569
0.050881
1
10,303
C
T
C
C
A
T
C
T
C
T
G
A
C
A
C
C
A
G
A
T
C
A
G
A
A
A
G
G
T
C
T
T
T
C
T
C
T
G
T
G
G
C
A
T
C
A
T
C
T
A
T
G
A
A
C
A
G
T
A
G
G
C
A
T
A
C
0.066536
0.029354
0.033268
0.04501
0.039139
0.007828
0.001957
0.031311
0.056751
0.023483
0.035225
0.015656
0.046967
0.052838
0.033268
0.027397
0.052838
0.041096
0.033268
0
0.007828
0.001957
0.021526
0.041096
0.054795
0.013699
0.033268
0.031311
0.037182
0.009785
0.019569
0.054795
1
10,304
C
A
A
A
G
A
C
A
A
G
C
C
C
A
A
G
G
A
G
G
C
G
G
T
C
A
C
C
G
T
G
G
C
C
G
T
G
A
A
G
A
T
G
T
T
G
A
A
A
G
G
T
G
A
G
C
G
G
G
G
A
G
G
C
G
T
0.048924
0.023483
0.048924
0.023483
0.037182
0.027397
0.007828
0.035225
0.039139
0.041096
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0.043053
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0.039139
0.033268
0.021526
0.023483
0.033268
0.031311
0.019569
0.033268
0.039139
1
10,305
T
T
A
C
T
G
C
A
T
A
G
G
G
G
T
C
T
T
C
T
T
A
A
T
C
G
C
C
T
G
T
A
T
G
G
T
G
G
T
A
A
C
A
G
T
C
A
T
C
C
T
G
T
G
C
C
G
A
A
T
G
A
A
G
A
G
0.039139
0.021526
0.048924
0.023483
0.035225
0.035225
0.009785
0.023483
0.048924
0.043053
0.037182
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0.035225
0.037182
0.029354
0.033268
0.056751
0.054795
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0.039139
0.031311
0.035225
0.031311
0.037182
0.017613
0.02544
0.033268
1
10,306
T
G
T
T
A
C
C
A
C
C
A
T
A
C
A
G
G
C
G
A
T
T
A
A
G
A
A
G
A
C
C
C
C
T
A
T
G
C
A
G
T
A
A
A
T
G
G
C
T
A
T
C
T
C
C
A
G
G
T
A
G
T
C
T
G
T
0.041096
0.021526
0.046967
0.02544
0.033268
0.037182
0.009785
0.023483
0.048924
0.041096
0.041096
0.017613
0.033268
0.037182
0.029354
0.029354
0.058708
0.056751
0.033268
0.007828
0.015656
0.013699
0.017613
0.029354
0.039139
0.033268
0.033268
0.029354
0.039139
0.019569
0.02544
0.031311
1
10,307
C
A
G
C
T
T
C
C
C
C
A
G
A
C
T
A
C
C
T
G
G
A
G
A
T
A
G
C
C
A
T
T
T
A
C
T
G
C
A
T
A
G
G
G
G
T
C
T
T
C
T
T
A
A
T
C
G
C
C
T
G
T
A
T
G
G
0.041096
0.021526
0.046967
0.023483
0.035225
0.037182
0.009785
0.02544
0.046967
0.041096
0.041096
0.017613
0.031311
0.037182
0.029354
0.029354
0.060665
0.056751
0.033268
0.007828
0.013699
0.013699
0.019569
0.027397
0.037182
0.037182
0.033268
0.029354
0.039139
0.019569
0.02544
0.031311
1
10,308
A
G
C
G
C
C
T
G
G
A
A
G
A
G
A
A
A
A
G
G
A
G
A
T
T
A
C
A
G
C
T
T
C
C
C
C
A
G
A
C
T
A
C
C
T
G
G
A
G
A
T
A
G
C
C
A
T
T
T
A
C
T
G
C
A
G
0.041096
0.021526
0.043053
0.02544
0.031311
0.039139
0.009785
0.027397
0.04501
0.039139
0.04501
0.017613
0.031311
0.031311
0.031311
0.031311
0.062622
0.056751
0.035225
0.007828
0.009785
0.011742
0.023483
0.027397
0.033268
0.035225
0.037182
0.033268
0.037182
0.019569
0.02544
0.033268
1
10,309
C
A
G
A
G
A
G
A
A
A
G
A
A
C
A
G
T
A
T
A
T
A
C
C
T
G
G
C
A
G
A
A
C
T
G
T
C
A
A
C
C
A
T
G
C
A
G
A
G
T
G
A
A
A
G
G
A
T
A
T
C
C
C
A
A
T
0.082192
0.031311
0.043053
0.041096
0.041096
0.02544
0.011742
0.019569
0.043053
0.019569
0.041096
0.048924
0.033268
0.021526
0.029354
0.041096
0.039139
0.033268
0.048924
0.015656
0.005871
0.009785
0.015656
0.02544
0.050881
0.013699
0.021526
0.027397
0.039139
0.009785
0.035225
0.035225
1
10,310
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
C
A
C
T
C
T
G
C
A
T
G
G
T
T
G
A
C
A
G
T
T
C
T
G
C
C
A
G
G
T
A
T
A
T
A
C
T
G
T
T
C
T
T
T
C
T
C
0.078278
0.031311
0.043053
0.041096
0.041096
0.02544
0.011742
0.019569
0.043053
0.019569
0.041096
0.048924
0.033268
0.021526
0.029354
0.041096
0.041096
0.033268
0.048924
0.017613
0.007828
0.009785
0.013699
0.02544
0.050881
0.015656
0.021526
0.027397
0.039139
0.009785
0.033268
0.035225
1
10,311
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
C
A
C
T
C
T
G
C
A
T
G
G
T
T
G
A
C
A
G
T
T
C
T
G
C
C
A
G
G
T
A
T
A
T
A
C
T
T
0.076321
0.031311
0.043053
0.039139
0.041096
0.02544
0.011742
0.019569
0.041096
0.021526
0.041096
0.04501
0.033268
0.021526
0.029354
0.041096
0.043053
0.035225
0.050881
0.017613
0.007828
0.009785
0.013699
0.023483
0.050881
0.015656
0.02544
0.029354
0.039139
0.009785
0.033268
0.033268
1
10,312
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
C
A
C
T
C
T
G
C
A
T
G
G
T
T
G
A
C
A
G
T
T
C
T
G
C
C
A
G
G
T
A
T
A
T
A
C
T
G
0.076321
0.031311
0.043053
0.039139
0.041096
0.02544
0.011742
0.019569
0.041096
0.021526
0.041096
0.04501
0.033268
0.021526
0.029354
0.041096
0.043053
0.035225
0.050881
0.017613
0.007828
0.009785
0.013699
0.023483
0.050881
0.015656
0.02544
0.029354
0.039139
0.009785
0.033268
0.033268
1
10,313
T
A
C
G
T
G
C
T
T
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
C
A
C
T
C
T
G
C
A
T
G
G
T
T
G
A
C
A
G
T
T
C
T
G
C
C
A
G
G
0.078278
0.031311
0.043053
0.039139
0.043053
0.02544
0.011742
0.019569
0.041096
0.023483
0.037182
0.04501
0.031311
0.021526
0.031311
0.043053
0.041096
0.037182
0.048924
0.017613
0.007828
0.009785
0.013699
0.023483
0.048924
0.015656
0.02544
0.031311
0.039139
0.009785
0.033268
0.031311
1
10,314
T
T
T
T
G
A
G
G
A
C
G
C
T
G
G
G
G
A
A
T
A
T
A
C
G
T
G
C
T
T
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
C
A
C
T
C
T
G
G
0.07045
0.031311
0.041096
0.035225
0.046967
0.023483
0.013699
0.019569
0.04501
0.02544
0.033268
0.04501
0.031311
0.021526
0.033268
0.04501
0.041096
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.017613
0.02544
0.031311
0.039139
0.009785
0.029354
0.029354
1
10,315
A
G
A
G
T
G
A
A
A
G
G
A
T
A
T
C
C
C
A
A
T
A
G
A
A
T
T
A
C
C
C
G
C
C
A
A
G
C
A
C
G
T
A
T
A
T
T
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
G
0.07045
0.031311
0.039139
0.035225
0.046967
0.023483
0.013699
0.019569
0.04501
0.02544
0.033268
0.04501
0.031311
0.021526
0.033268
0.04501
0.041096
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.017613
0.027397
0.031311
0.039139
0.009785
0.029354
0.029354
1
10,316
G
T
A
A
C
T
T
T
T
G
A
G
G
A
C
G
C
T
G
G
G
G
A
A
T
A
T
A
C
G
T
G
C
T
T
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
C
A
G
0.07045
0.033268
0.039139
0.035225
0.048924
0.023483
0.013699
0.019569
0.04501
0.02544
0.033268
0.04501
0.027397
0.021526
0.033268
0.046967
0.041096
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.017613
0.027397
0.031311
0.039139
0.009785
0.029354
0.027397
1
10,317
G
A
A
A
G
G
A
T
A
T
C
C
C
A
A
T
A
G
A
A
T
T
A
C
C
C
G
C
C
A
A
G
C
A
C
G
T
A
T
A
T
T
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
T
T
A
C
A
A
0.07045
0.033268
0.039139
0.035225
0.048924
0.023483
0.013699
0.021526
0.04501
0.02544
0.033268
0.04501
0.027397
0.021526
0.033268
0.046967
0.041096
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.017613
0.027397
0.031311
0.039139
0.009785
0.029354
0.02544
1
10,318
G
A
A
A
G
G
A
T
A
T
C
C
C
A
A
T
A
G
A
A
T
T
A
C
C
C
G
C
C
A
A
G
C
A
C
G
T
A
T
A
T
T
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
T
T
A
C
A
G
0.07045
0.033268
0.039139
0.035225
0.048924
0.023483
0.013699
0.021526
0.04501
0.02544
0.033268
0.04501
0.027397
0.021526
0.033268
0.046967
0.041096
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.017613
0.027397
0.031311
0.039139
0.009785
0.029354
0.02544
1
10,319
A
T
G
T
A
A
C
T
T
T
T
G
A
G
G
A
C
G
C
T
G
G
G
G
A
A
T
A
T
A
C
G
T
G
C
T
T
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
G
0.07045
0.033268
0.039139
0.035225
0.048924
0.023483
0.013699
0.021526
0.04501
0.02544
0.033268
0.04501
0.027397
0.019569
0.033268
0.046967
0.043053
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.017613
0.027397
0.031311
0.039139
0.009785
0.029354
0.02544
1
10,320
A
T
G
T
A
A
C
T
T
T
T
G
A
G
G
A
C
G
C
T
G
G
G
G
A
A
T
A
T
A
C
G
T
G
C
T
T
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
C
0.07045
0.033268
0.039139
0.035225
0.048924
0.023483
0.013699
0.021526
0.04501
0.02544
0.033268
0.04501
0.027397
0.019569
0.033268
0.046967
0.043053
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.017613
0.027397
0.031311
0.039139
0.009785
0.029354
0.02544
1
10,321
A
T
G
T
A
A
C
T
T
T
T
G
A
G
G
A
C
G
C
T
G
G
G
G
A
A
T
A
T
A
C
G
T
G
C
T
T
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
T
C
C
T
T
T
A
0.07045
0.033268
0.039139
0.035225
0.048924
0.023483
0.013699
0.021526
0.04501
0.02544
0.033268
0.04501
0.027397
0.019569
0.033268
0.046967
0.043053
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.017613
0.027397
0.031311
0.039139
0.009785
0.029354
0.02544
1
10,322
G
G
A
T
A
T
C
C
C
A
A
T
A
G
A
A
T
T
A
C
C
C
G
C
C
A
A
G
C
A
C
G
T
A
T
A
T
T
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
T
T
A
C
A
T
T
C
C
G
0.068493
0.033268
0.039139
0.035225
0.048924
0.02544
0.013699
0.021526
0.04501
0.02544
0.033268
0.043053
0.027397
0.019569
0.033268
0.046967
0.043053
0.039139
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.019569
0.027397
0.031311
0.039139
0.009785
0.027397
0.027397
1
10,323
A
T
A
T
C
C
C
A
A
T
A
G
A
A
T
T
A
C
C
C
G
C
C
A
A
G
C
A
C
G
T
A
T
A
T
T
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
T
T
A
C
A
T
T
C
C
G
A
C
0.068493
0.033268
0.039139
0.033268
0.048924
0.02544
0.013699
0.021526
0.04501
0.02544
0.033268
0.043053
0.027397
0.017613
0.033268
0.046967
0.04501
0.041096
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.019569
0.027397
0.031311
0.039139
0.009785
0.027397
0.027397
1
10,324
T
T
C
G
G
A
A
T
G
T
A
A
C
T
T
T
T
G
A
G
G
A
C
G
C
T
G
G
G
G
A
A
T
A
T
A
C
G
T
G
C
T
T
G
G
C
G
G
G
T
A
A
T
T
C
T
A
T
T
G
G
G
A
T
A
C
0.068493
0.033268
0.039139
0.033268
0.046967
0.02544
0.013699
0.021526
0.04501
0.027397
0.033268
0.043053
0.027397
0.017613
0.033268
0.046967
0.04501
0.041096
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.019569
0.027397
0.031311
0.039139
0.009785
0.027397
0.027397
1
10,325
A
A
T
A
G
A
A
T
T
A
C
C
C
G
C
C
A
A
G
C
A
C
G
T
A
T
A
T
T
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
T
T
A
C
A
T
T
C
C
G
A
A
T
A
T
A
G
A
G
0.068493
0.033268
0.039139
0.033268
0.04501
0.027397
0.013699
0.019569
0.04501
0.029354
0.035225
0.043053
0.027397
0.017613
0.033268
0.04501
0.04501
0.041096
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.019569
0.027397
0.031311
0.039139
0.009785
0.027397
0.027397
1
10,326
A
A
T
A
G
A
A
T
T
A
C
C
C
G
C
C
A
A
G
C
A
C
G
T
A
T
A
T
T
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
T
T
A
C
A
T
T
C
C
G
A
A
T
A
T
A
G
A
T
0.068493
0.033268
0.039139
0.033268
0.04501
0.027397
0.013699
0.019569
0.04501
0.029354
0.035225
0.043053
0.027397
0.017613
0.033268
0.04501
0.04501
0.041096
0.046967
0.021526
0.009785
0.009785
0.013699
0.029354
0.04501
0.019569
0.027397
0.031311
0.039139
0.009785
0.027397
0.027397
1
10,327
A
G
A
A
T
T
A
C
C
C
G
C
C
A
A
G
C
A
C
G
T
A
T
A
T
T
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
T
T
A
C
A
T
T
C
C
G
A
A
T
A
T
A
G
A
G
A
A
G
0.068493
0.033268
0.039139
0.033268
0.04501
0.027397
0.013699
0.019569
0.04501
0.029354
0.035225
0.043053
0.027397
0.017613
0.033268
0.043053
0.04501
0.041096
0.04501
0.021526
0.009785
0.009785
0.013699
0.031311
0.04501
0.019569
0.027397
0.031311
0.041096
0.009785
0.027397
0.027397
1
10,328
C
C
C
C
A
G
C
G
T
C
C
T
C
A
A
A
A
G
T
T
A
C
A
T
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C
C
G
A
A
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C
C
T
C
A
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T
C
T
C
T
T
T
G
T
C
C
G
T
G
G
T
G
T
T
A
C
0.066536
0.033268
0.039139
0.029354
0.043053
0.031311
0.015656
0.017613
0.043053
0.031311
0.035225
0.043053
0.023483
0.017613
0.031311
0.04501
0.04501
0.041096
0.046967
0.027397
0.009785
0.009785
0.013699
0.029354
0.043053
0.021526
0.027397
0.037182
0.037182
0.009785
0.027397
0.027397
1
10,329
C
A
T
T
C
C
G
A
A
T
A
T
A
G
A
G
A
A
C
C
T
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C
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T
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T
G
T
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A
A
C
A
C
C
G
G
C
G
G
C
C
T
A
G
A
A
A
A
C
A
A
0.062622
0.031311
0.037182
0.031311
0.046967
0.033268
0.017613
0.015656
0.041096
0.031311
0.035225
0.041096
0.023483
0.021526
0.033268
0.048924
0.041096
0.041096
0.043053
0.027397
0.009785
0.011742
0.015656
0.029354
0.041096
0.021526
0.031311
0.035225
0.037182
0.011742
0.02544
0.02544
1
10,330
C
A
T
T
C
C
G
A
A
T
A
T
A
G
A
G
A
A
C
C
T
C
A
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G
T
C
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G
T
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C
A
C
C
G
G
C
G
G
C
C
T
A
G
A
A
A
A
C
A
G
0.062622
0.031311
0.037182
0.031311
0.046967
0.033268
0.017613
0.015656
0.041096
0.031311
0.035225
0.041096
0.023483
0.021526
0.033268
0.048924
0.041096
0.041096
0.043053
0.027397
0.009785
0.011742
0.015656
0.029354
0.041096
0.021526
0.031311
0.035225
0.037182
0.011742
0.02544
0.02544
1
10,331
C
T
C
A
A
T
C
T
C
T
T
T
G
T
C
C
G
T
G
G
T
G
T
T
A
A
C
A
C
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G
G
C
G
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C
C
T
A
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A
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A
A
G
G
G
A
A
G
C
A
A
A
A
G
A
A
A
A
G
G
A
0.058708
0.031311
0.037182
0.029354
0.04501
0.033268
0.019569
0.015656
0.041096
0.031311
0.035225
0.041096
0.021526
0.021526
0.035225
0.048924
0.041096
0.043053
0.043053
0.027397
0.009785
0.013699
0.015656
0.029354
0.043053
0.021526
0.033268
0.035225
0.037182
0.011742
0.021526
0.027397
1
10,332
T
T
C
A
G
A
A
A
G
T
C
C
T
C
A
C
C
T
T
G
A
G
A
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C
T
T
G
A
G
G
T
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G
G
G
C
A
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C
C
C
G
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C
G
G
G
C
C
C
G
T
A
T
T
T
A
C
T
G
C
C
G
C
0.039139
0.033268
0.041096
0.02544
0.027397
0.02544
0.013699
0.043053
0.062622
0.021526
0.043053
0.007828
0.027397
0.021526
0.035225
0.031311
0.039139
0.048924
0.043053
0.021526
0.007828
0.003914
0.029354
0.060665
0.043053
0.019569
0.021526
0.035225
0.052838
0.023483
0.021526
0.029354
1
10,333
T
A
T
T
T
A
C
T
G
C
C
G
T
T
C
T
T
T
T
C
C
A
C
G
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C
T
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G
G
C
T
G
G
G
C
A
T
C
A
C
T
G
T
A
A
A
C
A
0.043053
0.02544
0.039139
0.027397
0.029354
0.029354
0.013699
0.031311
0.054795
0.029354
0.048924
0.007828
0.027397
0.02544
0.035225
0.035225
0.048924
0.048924
0.035225
0.021526
0.007828
0.003914
0.019569
0.056751
0.039139
0.02544
0.02544
0.043053
0.04501
0.017613
0.017613
0.041096
1
10,334
T
A
T
T
T
A
C
T
G
C
C
G
T
T
C
T
T
T
T
C
C
A
C
G
T
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C
T
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A
T
C
C
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C
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G
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T
G
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G
G
G
C
T
G
G
G
C
A
T
C
A
C
T
G
T
A
A
A
C
G
0.043053
0.02544
0.039139
0.027397
0.029354
0.029354
0.013699
0.031311
0.054795
0.029354
0.048924
0.007828
0.027397
0.02544
0.035225
0.035225
0.048924
0.048924
0.035225
0.021526
0.007828
0.003914
0.019569
0.056751
0.039139
0.02544
0.02544
0.043053
0.04501
0.017613
0.017613
0.041096
1
10,335
A
T
T
T
A
C
T
G
C
C
G
T
T
C
T
T
T
T
C
C
A
C
G
T
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C
T
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G
A
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C
C
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G
G
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T
G
T
G
G
G
G
C
T
G
G
G
C
A
T
C
A
C
T
G
T
A
A
A
C
C
G
0.043053
0.02544
0.039139
0.027397
0.029354
0.029354
0.013699
0.031311
0.054795
0.029354
0.048924
0.009785
0.027397
0.02544
0.035225
0.035225
0.048924
0.046967
0.035225
0.021526
0.007828
0.003914
0.019569
0.056751
0.039139
0.02544
0.02544
0.043053
0.04501
0.017613
0.017613
0.041096
1
10,336
A
G
G
T
T
T
A
C
A
G
T
G
A
T
G
C
C
C
A
G
C
C
C
C
A
C
A
T
C
C
A
G
T
G
G
A
T
C
A
A
G
C
A
C
G
T
G
G
A
A
A
A
G
A
A
C
G
G
C
A
G
T
A
A
A
G
0.043053
0.02544
0.039139
0.027397
0.029354
0.029354
0.013699
0.031311
0.054795
0.029354
0.048924
0.009785
0.027397
0.023483
0.035225
0.035225
0.048924
0.046967
0.035225
0.021526
0.007828
0.003914
0.019569
0.056751
0.039139
0.02544
0.02544
0.043053
0.04501
0.017613
0.019569
0.041096
1
10,337
A
G
G
T
T
T
A
C
A
G
T
G
A
T
G
C
C
C
A
G
C
C
C
C
A
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A
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C
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G
T
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A
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C
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C
G
T
G
G
A
A
A
A
G
A
A
C
G
G
C
A
G
T
A
A
A
C
0.043053
0.02544
0.039139
0.027397
0.029354
0.029354
0.013699
0.031311
0.054795
0.029354
0.048924
0.009785
0.027397
0.023483
0.035225
0.035225
0.048924
0.046967
0.035225
0.021526
0.007828
0.003914
0.019569
0.056751
0.039139
0.02544
0.02544
0.043053
0.04501
0.017613
0.019569
0.041096
1
10,338
A
G
G
T
T
T
A
C
A
G
T
G
A
T
G
C
C
C
A
G
C
C
C
C
A
C
A
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C
C
A
G
T
G
G
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T
C
A
A
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C
A
C
G
T
G
G
A
A
A
A
G
A
A
C
G
G
C
A
G
T
A
A
A
A
0.043053
0.02544
0.039139
0.027397
0.029354
0.029354
0.013699
0.031311
0.054795
0.029354
0.048924
0.009785
0.027397
0.023483
0.035225
0.035225
0.048924
0.046967
0.035225
0.021526
0.007828
0.003914
0.019569
0.056751
0.039139
0.02544
0.02544
0.043053
0.04501
0.017613
0.019569
0.041096
1
10,339
T
A
C
T
G
C
C
G
T
T
C
T
T
T
T
C
C
A
C
G
T
G
C
T
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G
A
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C
C
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C
T
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G
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T
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G
G
G
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C
T
G
G
G
C
A
T
C
A
C
T
G
T
A
A
A
C
C
T
T
G
G
0.043053
0.027397
0.039139
0.027397
0.031311
0.029354
0.013699
0.031311
0.054795
0.029354
0.048924
0.007828
0.027397
0.023483
0.035225
0.035225
0.048924
0.046967
0.035225
0.021526
0.007828
0.003914
0.017613
0.056751
0.039139
0.02544
0.02544
0.043053
0.04501
0.017613
0.019569
0.041096
1
10,340
C
T
G
C
A
A
G
G
T
T
T
A
C
A
G
T
G
A
T
G
C
C
C
A
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C
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C
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C
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T
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G
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T
C
A
A
G
C
A
C
G
T
G
G
A
A
A
A
G
A
A
C
G
G
C
A
A
0.043053
0.02544
0.039139
0.027397
0.031311
0.029354
0.013699
0.031311
0.054795
0.029354
0.048924
0.007828
0.027397
0.023483
0.035225
0.037182
0.050881
0.046967
0.035225
0.021526
0.007828
0.003914
0.017613
0.056751
0.037182
0.02544
0.02544
0.043053
0.04501
0.017613
0.019569
0.041096
1
10,341
G
G
A
T
G
T
G
G
G
G
C
T
G
G
G
C
A
T
C
A
C
T
G
T
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A
A
C
C
T
T
G
C
A
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A
C
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C
T
C
T
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C
G
T
C
T
C
C
T
C
C
G
A
C
C
A
C
T
G
T
G
A
0.043053
0.029354
0.037182
0.023483
0.033268
0.029354
0.015656
0.029354
0.052838
0.027397
0.046967
0.009785
0.027397
0.02544
0.035225
0.037182
0.050881
0.050881
0.037182
0.021526
0.009785
0.003914
0.011742
0.056751
0.037182
0.027397
0.023483
0.046967
0.043053
0.013699
0.019569
0.043053
1
10,342
G
G
A
T
G
T
G
G
G
G
C
T
G
G
G
C
A
T
C
A
C
T
G
T
A
A
A
C
C
T
T
G
C
A
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A
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C
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C
G
T
C
T
C
C
T
C
C
G
A
C
C
A
C
T
G
T
G
T
0.043053
0.029354
0.037182
0.023483
0.033268
0.029354
0.015656
0.029354
0.052838
0.027397
0.046967
0.009785
0.027397
0.02544
0.035225
0.037182
0.050881
0.050881
0.037182
0.021526
0.009785
0.003914
0.011742
0.056751
0.037182
0.027397
0.023483
0.046967
0.043053
0.013699
0.019569
0.043053
1
10,343
C
C
A
T
C
C
T
C
C
A
A
G
C
C
G
G
A
C
T
G
C
C
G
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C
A
A
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C
C
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T
G
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C
G
G
A
G
G
A
G
A
C
G
T
A
G
A
G
T
T
T
G
T
C
C
0.050881
0.02544
0.041096
0.019569
0.031311
0.031311
0.015656
0.029354
0.048924
0.02544
0.048924
0.009785
0.023483
0.02544
0.037182
0.035225
0.046967
0.048924
0.039139
0.02544
0.011742
0.009785
0.009785
0.056751
0.033268
0.031311
0.023483
0.046967
0.04501
0.015656
0.015656
0.041096
1
10,344
C
C
T
C
C
T
T
T
C
T
T
C
C
C
T
C
T
C
T
C
C
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G
A
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C
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C
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C
A
T
C
C
T
C
C
A
A
G
C
C
G
G
A
C
T
G
C
G
0.048924
0.02544
0.046967
0.021526
0.033268
0.031311
0.015656
0.031311
0.046967
0.02544
0.046967
0.011742
0.019569
0.02544
0.033268
0.037182
0.046967
0.048924
0.041096
0.02544
0.011742
0.009785
0.007828
0.048924
0.037182
0.029354
0.023483
0.046967
0.041096
0.019569
0.023483
0.037182
1
10,345
C
C
A
C
C
A
C
G
T
C
C
G
C
G
A
T
A
A
A
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T
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G
C
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G
A
T
C
T
T
C
C
T
G
C
C
C
T
G
A
G
A
A
C
A
0.054795
0.023483
0.054795
0.037182
0.029354
0.023483
0.005871
0.031311
0.046967
0.029354
0.041096
0.043053
0.029354
0.031311
0.031311
0.037182
0.029354
0.039139
0.031311
0.009785
0.015656
0.019569
0.027397
0.037182
0.046967
0.015656
0.031311
0.029354
0.037182
0.013699
0.037182
0.029354
1
10,346
C
A
C
G
G
C
A
G
G
G
G
C
G
A
T
C
T
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C
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T
T
A
T
G
G
C
G
C
A
A
A
C
T
G
T
T
G
G
G
0.056751
0.021526
0.056751
0.039139
0.031311
0.021526
0.005871
0.031311
0.048924
0.027397
0.039139
0.041096
0.027397
0.033268
0.029354
0.037182
0.029354
0.039139
0.033268
0.009785
0.015656
0.019569
0.027397
0.033268
0.048924
0.017613
0.029354
0.029354
0.037182
0.013699
0.039139
0.029354
1
10,347
T
T
C
T
A
A
A
C
G
A
G
A
G
G
T
G
C
C
G
G
T
G
G
C
T
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G
T
G
G
G
T
C
T
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G
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T
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T
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T
G
T
C
G
G
A
A
G
A
T
G
G
A
C
T
G
A
T
C
G
G
0.058708
0.031311
0.04501
0.035225
0.037182
0.037182
0.017613
0.021526
0.041096
0.039139
0.029354
0.015656
0.035225
0.031311
0.043053
0.054795
0.031311
0.039139
0.021526
0.021526
0.015656
0.009785
0.019569
0.035225
0.033268
0.015656
0.04501
0.031311
0.021526
0.011742
0.035225
0.039139
1
10,348
C
A
C
C
C
T
T
A
C
C
T
G
G
T
G
G
T
C
A
A
T
T
T
T
G
A
T
G
A
G
T
G
C
G
A
T
G
T
C
T
G
C
T
T
T
C
T
C
A
T
C
C
A
C
A
T
C
C
T
T
G
A
T
T
T
T
0.054795
0.029354
0.04501
0.027397
0.029354
0.037182
0.017613
0.027397
0.039139
0.037182
0.041096
0.007828
0.029354
0.02544
0.033268
0.048924
0.04501
0.043053
0.039139
0.019569
0.013699
0.007828
0.009785
0.04501
0.033268
0.019569
0.033268
0.039139
0.027397
0.013699
0.033268
0.046967
1
10,349
G
G
A
T
G
A
G
A
A
A
G
C
A
G
A
C
A
T
C
G
C
A
C
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C
A
T
C
A
A
A
A
T
T
G
A
C
C
A
C
C
A
G
G
T
A
A
G
G
G
T
G
T
T
C
T
C
G
C
C
T
G
C
A
G
C
0.060665
0.029354
0.04501
0.023483
0.033268
0.035225
0.017613
0.027397
0.039139
0.037182
0.041096
0.007828
0.027397
0.02544
0.035225
0.048924
0.04501
0.041096
0.037182
0.019569
0.013699
0.007828
0.009785
0.04501
0.033268
0.021526
0.033268
0.039139
0.027397
0.013699
0.031311
0.046967
1
10,350
C
G
G
C
C
G
G
G
A
G
A
G
T
T
C
G
T
G
G
T
C
G
C
C
A
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C
G
G
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C
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T
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C
A
A
A
A
C
A
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A
G
T
C
A
C
C
A
C
C
G
G
A
0.037182
0.035225
0.023483
0.015656
0.029354
0.031311
0.017613
0.027397
0.027397
0.046967
0.039139
0.009785
0.02544
0.027397
0.037182
0.035225
0.056751
0.056751
0.056751
0.031311
0.011742
0.021526
0.017613
0.041096
0.023483
0.031311
0.037182
0.046967
0.048924
0.005871
0.013699
0.033268
1
10,351
C
A
G
C
T
C
T
T
T
G
C
C
G
C
C
T
C
G
C
T
G
G
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G
C
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C
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G
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G
A
C
T
G
T
G
T
T
T
T
G
A
A
G
G
G
A
A
A
T
0.033268
0.035225
0.021526
0.013699
0.031311
0.033268
0.017613
0.027397
0.027397
0.048924
0.035225
0.009785
0.021526
0.033268
0.035225
0.037182
0.056751
0.058708
0.056751
0.031311
0.011742
0.021526
0.021526
0.039139
0.021526
0.033268
0.039139
0.050881
0.041096
0.005871
0.013699
0.035225
1
10,352
A
G
A
G
G
G
A
C
A
G
A
G
G
C
T
C
A
C
G
T
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G
A
T
G
A
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G
G
C
G
T
C
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A
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G
T
C
C
A
T
G
T
C
T
G
A
G
T
T
G
C
G
G
A
T
0.031311
0.027397
0.02544
0.013699
0.029354
0.035225
0.017613
0.023483
0.029354
0.048924
0.043053
0.009785
0.021526
0.033268
0.033268
0.037182
0.056751
0.058708
0.052838
0.031311
0.011742
0.021526
0.019569
0.043053
0.021526
0.033268
0.041096
0.048924
0.046967
0.007828
0.013699
0.031311
1
10,353
A
A
T
T
G
A
A
G
T
A
A
T
T
C
C
T
G
A
T
A
C
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C
G
T
T
T
T
C
T
C
T
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T
T
C
C
C
A
A
T
A
T
0.046967
0.021526
0.04501
0.035225
0.02544
0.027397
0.02544
0.019569
0.048924
0.041096
0.054795
0.021526
0.021526
0.011742
0.031311
0.027397
0.054795
0.039139
0.027397
0.019569
0.011742
0.009785
0.017613
0.048924
0.048924
0.035225
0.02544
0.02544
0.060665
0.013699
0.021526
0.035225
1
10,354
C
C
T
T
C
C
G
C
T
G
C
A
G
T
G
A
T
C
G
A
A
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G
C
A
A
G
C
A
T
A
A
A
A
T
G
G
T
A
C
C
A
T
0.088063
0.035225
0.054795
0.039139
0.027397
0.033268
0.007828
0.035225
0.037182
0.02544
0.021526
0.027397
0.033268
0.056751
0.041096
0.021526
0.031311
0.054795
0.017613
0.001957
0.015656
0.009785
0.017613
0.015656
0.056751
0.021526
0.031311
0.011742
0.035225
0.02544
0.031311
0.037182
1
10,355
T
G
C
G
T
T
C
T
C
A
T
A
C
T
G
G
A
G
A
A
A
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C
C
T
T
C
C
G
C
T
G
C
A
G
T
G
A
T
C
G
A
C
0.09002
0.033268
0.052838
0.046967
0.029354
0.027397
0.007828
0.031311
0.041096
0.027397
0.017613
0.033268
0.035225
0.060665
0.043053
0.015656
0.031311
0.04501
0.017613
0.001957
0.015656
0.009785
0.017613
0.015656
0.054795
0.021526
0.035225
0.005871
0.031311
0.02544
0.037182
0.041096
1
10,356
A
C
T
T
A
C
A
A
T
G
G
T
A
G
G
G
T
C
T
A
C
A
T
T
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C
C
A
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C
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A
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G
C
C
C
T
G
C
G
T
G
C
T
C
A
G
C
A
C
T
G
C
T
G
A
T
0.113503
0.021526
0.052838
0.060665
0.031311
0.015656
0.005871
0.031311
0.056751
0.027397
0.029354
0.037182
0.029354
0.033268
0.037182
0.015656
0.039139
0.033268
0.013699
0
0.003914
0.001957
0.019569
0.033268
0.050881
0.021526
0.019569
0.013699
0.033268
0.027397
0.048924
0.041096
1
10,357
T
T
C
A
T
A
T
A
G
G
G
A
A
A
C
C
T
G
A
A
A
A
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T
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G
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G
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C
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C
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C
C
A
C
C
T
G
C
C
C
G
T
T
A
A
C
A
T
T
C
T
0.088063
0.031311
0.052838
0.04501
0.031311
0.02544
0.013699
0.037182
0.041096
0.027397
0.037182
0.039139
0.021526
0.031311
0.029354
0.02544
0.033268
0.031311
0.019569
0.005871
0.011742
0.011742
0.029354
0.02544
0.04501
0.021526
0.02544
0.017613
0.031311
0.029354
0.054795
0.029354
1
10,358
A
G
G
G
T
A
A
T
C
T
T
T
G
G
T
G
T
A
G
C
C
T
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C
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C
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C
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C
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G
A
T
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C
A
T
T
T
A
C
T
C
G
T
T
G
T
T
T
G
T
C
C
T
G
C
0.136986
0.031311
0.033268
0.066536
0.048924
0.021526
0.005871
0.031311
0.043053
0.015656
0.021526
0.043053
0.027397
0.035225
0.037182
0.027397
0.027397
0.039139
0.017613
0.001957
0.011742
0
0.031311
0.019569
0.039139
0.011742
0.023483
0.011742
0.029354
0.037182
0.056751
0.015656
1
10,359
A
A
A
T
A
A
A
A
T
G
T
A
A
A
A
A
A
A
A
A
A
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C
T
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T
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C
C
A
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C
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T
G
C
A
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C
T
C
G
G
A
A
G
T
A
T
T
T
C
T
C
C
A
C
A
G
T
0.154599
0.035225
0.033268
0.060665
0.046967
0.019569
0.005871
0.035225
0.033268
0.017613
0.02544
0.04501
0.02544
0.029354
0.04501
0.027397
0.027397
0.035225
0.013699
0.001957
0.011742
0
0.029354
0.019569
0.029354
0.011742
0.029354
0.019569
0.023483
0.035225
0.054795
0.017613
1
10,360
T
C
G
A
G
A
G
T
C
C
A
T
T
G
A
A
A
T
T
A
T
T
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A
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C
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C
T
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G
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C
T
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C
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G
A
G
G
G
T
A
G
C
C
A
G
C
T
G
T
T
T
T
C
A
A
0.086106
0.043053
0.041096
0.039139
0.04501
0.019569
0.021526
0.027397
0.031311
0.033268
0.02544
0.039139
0.02544
0.048924
0.04501
0.023483
0.035225
0.04501
0.017613
0.005871
0.011742
0.007828
0.015656
0.023483
0.035225
0.021526
0.029354
0.027397
0.029354
0.023483
0.043053
0.033268
1
10,361
A
A
C
C
C
A
T
G
G
C
G
A
C
A
T
T
A
T
C
A
G
G
T
T
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G
C
G
C
C
T
C
C
G
C
T
G
G
T
G
A
T
C
A
A
G
G
A
G
G
A
T
G
A
G
C
T
T
C
G
A
G
A
G
T
T
0.082192
0.039139
0.048924
0.033268
0.037182
0.021526
0.019569
0.02544
0.029354
0.04501
0.029354
0.033268
0.023483
0.039139
0.04501
0.021526
0.039139
0.050881
0.02544
0.007828
0.011742
0.009785
0.013699
0.027397
0.033268
0.021526
0.027397
0.031311
0.035225
0.021526
0.041096
0.029354
1
10,362
G
A
A
G
G
T
G
T
G
T
C
T
A
C
G
A
C
T
T
C
G
A
G
A
T
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A
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G
G
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C
T
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C
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G
G
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C
C
A
A
C
C
C
A
T
G
G
C
G
A
C
A
T
T
A
T
C
A
C
0.078278
0.029354
0.048924
0.033268
0.031311
0.027397
0.013699
0.02544
0.031311
0.043053
0.033268
0.02544
0.029354
0.035225
0.04501
0.027397
0.037182
0.058708
0.029354
0.007828
0.015656
0.009785
0.011742
0.035225
0.031311
0.023483
0.023483
0.033268
0.039139
0.017613
0.035225
0.033268
1
10,363
A
T
T
T
T
T
C
T
T
T
A
G
A
T
T
G
G
G
A
T
G
C
T
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G
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G
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A
C
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C
G
A
G
A
T
A
A
T
G
G
A
C
T
T
C
T
G
G
C
C
C
0.064579
0.031311
0.048924
0.031311
0.033268
0.029354
0.015656
0.023483
0.031311
0.043053
0.035225
0.019569
0.029354
0.041096
0.043053
0.027397
0.037182
0.062622
0.031311
0.009785
0.015656
0.009785
0.011742
0.035225
0.029354
0.023483
0.023483
0.037182
0.041096
0.017613
0.037182
0.029354
1
10,364
G
T
A
G
C
T
T
C
A
T
G
A
G
T
T
C
A
T
T
T
C
T
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A
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A
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C
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T
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C
A
T
T
T
T
C
A
G
C
A
A
G
G
T
T
T
T
C
T
T
0.117417
0.033268
0.046967
0.072407
0.037182
0.015656
0.013699
0.031311
0.048924
0.023483
0.029354
0.039139
0.019569
0.029354
0.043053
0.015656
0.027397
0.017613
0.005871
0.007828
0.003914
0.005871
0.029354
0.029354
0.037182
0.023483
0.029354
0.015656
0.023483
0.02544
0.07045
0.031311
1
10,365
A
T
G
A
C
A
T
C
A
T
G
C
T
G
A
C
C
A
T
T
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C
C
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C
G
G
T
G
G
C
A
A
T
C
C
A
C
T
A
G
G
C
T
0.056751
0.007828
0.035225
0.054795
0.033268
0.023483
0.003914
0.041096
0.037182
0.037182
0.035225
0.02544
0.027397
0.037182
0.031311
0.048924
0.050881
0.046967
0.021526
0.003914
0.005871
0.005871
0.029354
0.035225
0.031311
0.02544
0.041096
0.037182
0.027397
0.019569
0.035225
0.046967
1
10,366
T
A
G
T
G
G
A
T
T
G
C
C
A
C
C
G
T
A
T
G
T
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G
T
C
A
G
C
A
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G
A
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G
T
C
A
T
C
A
T
T
0.056751
0.007828
0.035225
0.054795
0.035225
0.023483
0.003914
0.041096
0.037182
0.037182
0.033268
0.02544
0.027397
0.037182
0.031311
0.050881
0.050881
0.048924
0.021526
0.003914
0.005871
0.005871
0.029354
0.033268
0.031311
0.02544
0.041096
0.037182
0.02544
0.019569
0.035225
0.046967
1
10,367
C
C
T
T
G
G
A
A
A
G
G
C
C
C
T
T
T
C
T
G
G
G
G
G
C
T
T
A
T
A
C
C
C
T
G
T
A
A
G
T
T
T
C
A
T
G
T
T
C
C
C
C
C
T
C
T
T
T
C
C
A
T
T
T
C
T
0.080235
0.02544
0.035225
0.064579
0.052838
0.02544
0.001957
0.029354
0.02544
0.015656
0.037182
0.048924
0.029354
0.029354
0.04501
0.035225
0.043053
0.041096
0.050881
0.003914
0.001957
0
0.017613
0.011742
0.043053
0.017613
0.017613
0.02544
0.033268
0.031311
0.039139
0.041096
1
10,368
C
A
G
A
C
C
T
G
A
T
A
T
A
G
T
C
C
T
C
C
T
T
G
G
A
A
A
G
G
C
C
C
T
T
T
C
T
G
G
G
G
G
C
T
T
A
T
A
C
C
C
T
G
T
A
A
G
T
T
T
C
A
T
G
T
A
0.082192
0.02544
0.035225
0.066536
0.056751
0.021526
0.001957
0.029354
0.02544
0.015656
0.037182
0.048924
0.029354
0.031311
0.04501
0.037182
0.043053
0.039139
0.04501
0.003914
0.001957
0
0.017613
0.011742
0.041096
0.017613
0.021526
0.02544
0.031311
0.029354
0.041096
0.041096
1
10,369
T
T
T
C
A
T
A
A
T
C
A
A
C
A
G
C
C
A
G
C
C
A
T
C
T
A
C
C
A
G
T
T
C
T
G
G
C
C
A
A
T
C
C
T
G
T
C
T
G
T
A
T
T
T
C
A
T
C
A
G
C
A
A
T
A
T
0.084149
0.027397
0.035225
0.060665
0.052838
0.021526
0.001957
0.031311
0.033268
0.013699
0.039139
0.054795
0.033268
0.027397
0.043053
0.029354
0.043053
0.035225
0.04501
0.003914
0.001957
0
0.023483
0.015656
0.041096
0.017613
0.015656
0.02544
0.033268
0.031311
0.039139
0.039139
1
10,370
A
T
A
A
T
C
A
A
C
A
G
C
C
A
G
C
C
A
T
C
T
A
C
C
A
G
T
T
C
T
G
G
C
C
A
A
T
C
C
T
G
T
C
T
G
T
A
T
T
T
C
A
T
C
A
G
C
A
A
T
A
A
A
G
A
G
0.084149
0.027397
0.035225
0.060665
0.052838
0.019569
0.001957
0.029354
0.035225
0.013699
0.041096
0.054795
0.033268
0.027397
0.043053
0.029354
0.041096
0.033268
0.04501
0.003914
0.001957
0
0.027397
0.015656
0.041096
0.017613
0.015656
0.02544
0.033268
0.031311
0.039139
0.039139
1
10,371
A
C
G
T
G
A
C
A
A
C
C
T
G
G
T
G
C
C
T
G
G
T
G
C
A
G
A
G
C
T
C
T
C
G
C
A
C
T
C
C
C
A
T
T
A
G
G
T
A
A
C
C
T
G
G
A
T
C
C
G
G
A
A
C
A
G
0.046967
0.035225
0.043053
0.052838
0.037182
0.021526
0.013699
0.033268
0.041096
0.037182
0.039139
0.021526
0.02544
0.029354
0.031311
0.035225
0.054795
0.037182
0.015656
0.003914
0.009785
0.011742
0.02544
0.029354
0.054795
0.011742
0.039139
0.02544
0.033268
0.021526
0.04501
0.037182
1
10,372
G
C
C
T
G
G
T
G
C
A
G
A
G
C
T
C
T
C
G
C
A
C
T
C
C
C
A
T
T
A
G
G
T
A
A
C
C
T
G
G
A
T
C
C
G
G
A
A
C
A
A
C
A
A
C
G
C
C
T
G
C
T
T
C
A
C
0.048924
0.035225
0.043053
0.054795
0.033268
0.023483
0.013699
0.033268
0.043053
0.041096
0.037182
0.023483
0.02544
0.029354
0.031311
0.035225
0.050881
0.037182
0.011742
0.003914
0.009785
0.011742
0.02544
0.031311
0.056751
0.009785
0.039139
0.021526
0.033268
0.023483
0.04501
0.037182
1
10,373
G
T
A
G
C
G
T
G
C
T
C
T
T
C
A
G
G
A
T
C
C
A
A
A
T
G
T
G
G
C
T
G
C
G
T
T
C
A
T
G
G
T
A
G
A
A
C
C
A
A
T
T
C
A
G
G
G
T
G
A
A
G
C
A
G
T
0.052838
0.037182
0.039139
0.058708
0.035225
0.023483
0.013699
0.029354
0.035225
0.039139
0.039139
0.023483
0.02544
0.033268
0.035225
0.035225
0.04501
0.037182
0.013699
0.003914
0.009785
0.011742
0.02544
0.033268
0.052838
0.005871
0.035225
0.02544
0.031311
0.023483
0.048924
0.041096
1
10,374
C
A
C
A
G
A
C
C
C
A
A
C
C
A
G
T
T
A
C
G
A
T
G
G
T
T
T
T
G
G
A
C
C
A
T
T
T
A
T
G
C
C
G
G
G
A
T
T
C
G
A
C
A
T
C
A
T
T
C
C
C
T
A
T
A
A
0.068493
0.039139
0.037182
0.056751
0.039139
0.021526
0.007828
0.041096
0.033268
0.037182
0.013699
0.043053
0.033268
0.031311
0.04501
0.031311
0.041096
0.037182
0.029354
0.009785
0.011742
0.005871
0.027397
0.021526
0.043053
0.017613
0.02544
0.013699
0.02544
0.021526
0.04501
0.04501
1
10,375
G
T
A
A
C
T
G
G
T
T
G
G
G
T
C
T
G
T
G
G
A
A
C
T
G
G
A
G
A
T
A
G
C
A
G
A
C
A
A
C
G
T
C
C
T
A
C
C
C
C
A
G
A
A
G
T
T
C
C
C
A
G
C
T
A
T
0.07045
0.035225
0.041096
0.064579
0.035225
0.021526
0.007828
0.041096
0.02544
0.031311
0.021526
0.04501
0.029354
0.033268
0.046967
0.031311
0.031311
0.037182
0.029354
0.009785
0.011742
0.005871
0.031311
0.015656
0.039139
0.021526
0.027397
0.021526
0.02544
0.017613
0.050881
0.043053
1
10,376
G
G
T
C
T
G
T
G
G
A
A
C
T
G
G
A
G
A
T
A
G
C
A
G
A
C
A
A
C
G
T
C
C
T
A
C
C
C
C
A
G
A
A
G
T
T
C
C
C
A
G
C
T
A
C
A
A
A
G
G
G
G
A
A
A
G
0.07045
0.033268
0.041096
0.060665
0.035225
0.021526
0.007828
0.041096
0.031311
0.031311
0.021526
0.04501
0.02544
0.033268
0.04501
0.031311
0.033268
0.037182
0.029354
0.009785
0.011742
0.005871
0.031311
0.019569
0.041096
0.021526
0.027397
0.021526
0.02544
0.019569
0.048924
0.041096
1
10,377
G
A
C
T
C
T
T
C
A
G
A
G
C
A
T
T
C
A
C
A
A
T
C
T
T
G
G
G
G
T
G
A
C
A
A
T
G
C
C
C
T
T
G
G
T
T
G
A
C
A
G
C
A
C
T
G
T
A
A
G
A
A
C
T
C
A
0.117417
0.033268
0.048924
0.068493
0.037182
0.019569
0.005871
0.037182
0.037182
0.021526
0.035225
0.07045
0.013699
0.031311
0.043053
0.015656
0.019569
0.017613
0.011742
0.001957
0
0
0.035225
0.027397
0.039139
0.015656
0.017613
0.011742
0.023483
0.037182
0.068493
0.037182
1
10,378
T
T
G
A
A
A
G
G
G
A
A
T
A
T
A
A
G
T
A
T
G
G
T
G
C
A
C
A
C
A
A
C
T
A
C
C
A
T
C
C
T
T
T
A
C
C
T
G
T
A
G
C
C
C
T
G
G
A
G
A
G
A
G
G
A
C
0.121331
0.027397
0.046967
0.043053
0.046967
0.019569
0.007828
0.031311
0.054795
0.021526
0.031311
0.033268
0.019569
0.033268
0.041096
0.033268
0.037182
0.031311
0.011742
0.005871
0.001957
0.003914
0.021526
0.033268
0.046967
0.019569
0.037182
0.015656
0.033268
0.027397
0.031311
0.029354
1
10,379
G
G
G
C
T
A
C
A
G
G
T
A
A
A
G
G
A
T
G
G
T
A
G
T
T
G
T
G
T
G
C
A
C
C
A
T
A
C
T
T
A
T
A
T
T
C
C
C
T
T
T
C
A
A
A
A
A
T
G
T
C
A
T
C
A
T
0.123288
0.027397
0.048924
0.043053
0.046967
0.019569
0.007828
0.031311
0.054795
0.019569
0.033268
0.033268
0.019569
0.033268
0.041096
0.031311
0.033268
0.033268
0.013699
0.005871
0.001957
0.003914
0.021526
0.033268
0.046967
0.019569
0.033268
0.017613
0.035225
0.027397
0.031311
0.027397
1
10,380
G
C
A
A
A
C
C
T
C
T
G
C
A
A
A
T
G
T
G
C
T
A
G
T
T
T
G
G
A
A
A
A
C
A
T
T
G
T
G
T
C
C
T
T
C
A
A
G
T
A
G
A
A
A
A
A
C
C
A
C
A
G
A
T
C
T
0.099804
0.027397
0.043053
0.037182
0.031311
0.02544
0.009785
0.037182
0.04501
0.029354
0.04501
0.019569
0.02544
0.027397
0.043053
0.029354
0.04501
0.037182
0.019569
0.003914
0.001957
0.003914
0.02544
0.043053
0.035225
0.021526
0.037182
0.019569
0.041096
0.02544
0.027397
0.037182
1
10,381
A
A
A
C
C
T
C
T
G
C
A
A
A
T
G
T
G
C
T
A
G
T
T
T
G
G
A
A
A
A
C
A
T
T
G
T
G
T
C
C
T
T
C
A
A
G
T
A
G
A
A
A
A
A
C
C
A
C
A
G
A
T
C
T
G
C
0.099804
0.027397
0.043053
0.035225
0.031311
0.02544
0.009785
0.037182
0.04501
0.029354
0.04501
0.019569
0.02544
0.027397
0.043053
0.029354
0.04501
0.037182
0.019569
0.003914
0.001957
0.003914
0.02544
0.043053
0.035225
0.021526
0.039139
0.019569
0.041096
0.02544
0.027397
0.037182
1
10,382
C
A
G
C
A
A
A
T
C
C
T
G
C
A
G
G
G
T
G
T
A
G
A
C
C
C
T
C
T
G
C
A
C
G
C
C
C
A
G
G
G
A
C
C
G
C
T
C
G
A
T
C
C
C
A
T
C
C
T
G
C
A
A
G
T
T
0.029354
0.023483
0.033268
0.017613
0.029354
0.039139
0.017613
0.023483
0.029354
0.048924
0.048924
0.015656
0.021526
0.023483
0.039139
0.041096
0.064579
0.04501
0.041096
0.019569
0.017613
0.029354
0.011742
0.041096
0.023483
0.02544
0.060665
0.041096
0.033268
0.019569
0.011742
0.033268
1
10,383
G
G
C
C
T
C
G
G
G
A
G
C
G
G
C
C
C
G
C
A
T
C
C
G
T
G
G
G
G
A
G
A
C
G
C
T
G
G
G
C
C
T
C
A
T
T
G
G
C
T
T
T
G
G
T
A
C
G
T
G
C
C
A
C
C
T
0.009785
0.019569
0.021526
0.007828
0.02544
0.037182
0.027397
0.017613
0.039139
0.035225
0.056751
0
0.029354
0.017613
0.02544
0.04501
0.062622
0.054795
0.078278
0.039139
0.009785
0.02544
0.011742
0.052838
0.023483
0.021526
0.046967
0.060665
0.052838
0.019569
0
0.02544
1
10,384
A
G
C
C
A
G
C
G
C
T
G
C
C
T
C
G
C
A
C
T
C
A
C
C
G
A
G
C
T
C
G
C
C
G
G
C
A
G
C
C
T
T
G
A
T
G
T
C
C
A
C
G
T
T
G
T
C
A
T
A
G
C
C
A
C
T
0.003914
0.017613
0.027397
0
0.031311
0.037182
0.015656
0.017613
0.023483
0.060665
0.064579
0.007828
0.017613
0.017613
0.019569
0.058708
0.074364
0.056751
0.058708
0.035225
0.013699
0.021526
0.013699
0.050881
0.023483
0.017613
0.050881
0.080235
0.039139
0.007828
0.001957
0.033268
1
10,385
T
C
C
T
G
T
A
A
G
C
T
G
C
A
C
T
G
C
A
G
A
G
A
G
C
C
C
C
A
C
G
C
C
A
C
A
A
G
C
C
C
T
G
G
C
C
A
C
T
G
G
C
A
T
C
A
G
G
A
A
G
G
C
T
C
A
0.017613
0.011742
0.023483
0.003914
0.023483
0.013699
0.02544
0.019569
0.02544
0.080235
0.050881
0.007828
0.015656
0.023483
0.013699
0.041096
0.097847
0.062622
0.062622
0.023483
0.011742
0.021526
0.011742
0.043053
0.015656
0.023483
0.058708
0.091977
0.031311
0.005871
0.009785
0.031311
1
10,386
C
A
C
T
A
C
G
G
C
T
C
G
C
G
C
G
C
T
G
G
C
C
G
C
C
C
A
G
G
G
C
C
T
T
C
C
T
G
T
A
A
G
C
T
G
C
A
C
T
G
C
A
G
A
G
A
G
C
C
C
C
A
C
G
C
C
0.021526
0.011742
0.023483
0.005871
0.021526
0.015656
0.019569
0.019569
0.029354
0.082192
0.048924
0.009785
0.019569
0.027397
0.015656
0.033268
0.09589
0.060665
0.058708
0.023483
0.011742
0.023483
0.011742
0.04501
0.015656
0.023483
0.058708
0.086106
0.031311
0.007828
0.009785
0.031311
1
10,387
C
T
G
G
G
C
G
G
C
C
A
G
C
G
C
G
C
G
A
G
C
C
G
T
A
G
T
G
G
G
G
C
C
G
A
T
G
G
C
T
G
C
A
A
A
C
T
A
T
A
A
A
G
A
C
A
G
A
A
G
A
G
A
A
A
T
0.021526
0.011742
0.023483
0.005871
0.023483
0.013699
0.019569
0.021526
0.029354
0.084149
0.048924
0.009785
0.015656
0.027397
0.015656
0.037182
0.097847
0.060665
0.052838
0.017613
0.013699
0.027397
0.011742
0.048924
0.015656
0.021526
0.060665
0.086106
0.02544
0.007828
0.009785
0.033268
1
10,388
T
C
A
C
A
T
A
C
A
G
T
C
T
C
A
A
G
C
A
C
A
T
T
C
A
G
G
A
G
T
T
A
T
C
T
G
G
T
G
A
C
A
A
T
A
T
C
G
A
T
C
A
A
A
T
T
A
A
G
G
T
A
A
G
T
C
0.056751
0.021526
0.039139
0.037182
0.037182
0.02544
0.001957
0.021526
0.04501
0.041096
0.052838
0.015656
0.033268
0.031311
0.035225
0.033268
0.058708
0.039139
0.033268
0.013699
0.003914
0.003914
0.017613
0.04501
0.037182
0.021526
0.037182
0.039139
0.041096
0.007828
0.02544
0.046967
1
10,389
G
G
G
A
C
T
A
A
A
A
A
A
T
G
T
G
A
T
G
C
T
G
G
C
T
G
G
A
A
C
C
C
C
C
T
G
T
G
G
G
G
A
A
C
A
G
A
A
A
A
C
A
A
G
A
T
C
A
G
T
C
C
T
T
G
A
0.056751
0.021526
0.037182
0.031311
0.037182
0.027397
0
0.019569
0.04501
0.043053
0.056751
0.013699
0.031311
0.033268
0.031311
0.029354
0.07045
0.046967
0.031311
0.011742
0.003914
0.003914
0.017613
0.039139
0.035225
0.02544
0.039139
0.046967
0.039139
0.007828
0.023483
0.043053
1
10,390
G
G
G
A
C
T
A
A
A
A
A
A
T
G
T
G
A
T
G
C
T
G
G
C
T
G
G
A
A
C
C
C
C
C
T
G
T
G
G
G
G
A
A
C
A
G
A
A
A
A
C
A
A
G
A
T
C
A
G
T
C
C
T
T
G
T
0.056751
0.021526
0.037182
0.031311
0.037182
0.027397
0
0.019569
0.04501
0.043053
0.056751
0.013699
0.031311
0.033268
0.031311
0.029354
0.07045
0.046967
0.031311
0.011742
0.003914
0.003914
0.017613
0.039139
0.035225
0.02544
0.039139
0.046967
0.039139
0.007828
0.023483
0.043053
1