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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
10,091
T
C
C
A
C
C
A
G
G
G
A
G
T
A
A
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A
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C
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T
C
A
G
A
G
G
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G
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A
T
T
A
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10,092
T
C
C
A
C
C
A
G
G
G
A
G
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A
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A
T
T
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C
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A
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C
A
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A
G
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T
A
T
T
A
T
T
A
T
A
G
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T
A
C
C
T
G
T
T
A
A
A
G
T
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1
10,093
T
C
A
G
A
G
G
C
G
C
T
A
T
G
T
G
T
A
T
T
A
T
T
A
T
A
G
C
T
A
C
C
T
G
T
T
A
A
A
G
A
A
T
C
A
T
C
T
G
G
A
T
T
A
T
A
G
A
C
C
A
G
T
G
G
C
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1
10,094
G
G
C
A
C
T
G
T
T
G
T
T
T
C
A
C
A
A
G
A
T
G
A
T
G
T
T
T
G
A
A
A
C
T
A
T
T
C
C
A
A
T
G
T
T
C
A
G
T
G
G
C
G
G
A
A
C
T
T
G
C
A
G
T
A
T
0.093933
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0.033268
1
10,095
G
A
A
A
C
T
A
T
T
C
C
A
A
T
G
T
T
C
A
G
T
G
G
C
G
G
A
A
C
T
T
G
C
A
G
T
A
A
G
T
G
C
T
T
G
A
A
A
T
T
C
T
C
A
T
C
C
T
T
C
C
A
T
G
T
G
0.091977
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1
10,096
A
G
A
C
A
A
G
T
T
C
A
T
G
T
A
C
T
T
T
G
A
G
T
T
C
C
C
T
C
A
G
C
C
G
T
T
A
C
C
T
G
T
G
T
G
T
G
G
T
G
A
T
A
T
C
A
A
A
G
T
A
G
A
G
T
T
0.086106
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0
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0.029354
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0.054795
0.041096
1
10,097
G
A
T
A
T
T
T
C
T
C
C
C
A
A
T
G
A
A
A
G
T
A
A
A
G
T
A
C
A
A
A
C
C
T
T
T
T
T
T
A
G
C
A
T
C
T
T
G
T
T
C
T
G
T
T
T
G
T
G
G
A
A
G
A
A
G
0.086106
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0
0.015656
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0.019569
0.021526
0.013699
0.033268
0.027397
0.064579
0.037182
1
10,098
C
C
T
C
T
G
G
T
C
C
T
G
G
T
A
T
G
A
A
G
A
A
T
G
T
A
T
T
T
A
C
C
C
A
A
A
A
G
T
G
A
A
A
C
A
T
T
T
T
G
T
C
C
T
A
A
A
A
A
A
A
A
A
A
A
A
0.168297
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0.023483
0.054795
0.050881
1
10,099
A
G
G
T
T
T
C
C
T
C
T
G
G
T
C
C
T
G
G
T
A
T
G
A
A
G
A
A
T
G
T
A
T
T
T
A
C
C
C
A
A
A
A
G
T
G
A
A
A
C
A
T
T
T
T
G
T
C
C
T
A
A
A
A
A
C
0.164384
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0.043053
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0.054795
0.048924
1
10,100
T
G
A
G
G
T
T
T
C
C
T
C
T
G
G
T
C
C
T
G
G
T
A
T
G
A
A
G
A
A
T
G
T
A
T
T
T
A
C
C
C
A
A
A
A
G
T
G
A
A
A
C
A
T
T
T
T
G
T
C
C
T
A
A
A
C
0.166341
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0.023483
0.054795
0.048924
1
10,101
G
T
A
T
C
G
G
T
T
G
G
C
T
T
T
G
T
C
T
T
T
A
T
T
T
G
C
T
T
T
G
T
C
A
A
G
A
T
C
A
T
T
T
T
T
T
G
T
T
A
A
A
G
T
A
A
G
T
A
C
T
A
G
A
T
T
0.162427
0.031311
0.054795
0.060665
0.052838
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0.007828
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0.021526
0.001957
0.015656
0.039139
0.058708
0.037182
1
10,102
T
T
C
A
T
T
T
T
A
A
A
T
T
T
T
C
T
T
T
C
T
C
T
A
G
G
T
G
A
A
G
C
T
G
T
A
C
T
T
C
A
C
A
A
A
A
A
C
A
G
T
A
G
A
G
G
A
G
C
C
G
T
C
A
A
C
0.1409
0.041096
0.039139
0.064579
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0.019569
0.001957
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0.046967
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0.001957
0
0
0.02544
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0.04501
0.015656
0.011742
0.007828
0.013699
0.019569
0.07045
0.056751
1
10,103
T
G
A
A
G
G
A
T
G
G
C
T
G
G
A
A
C
A
G
G
G
T
C
T
C
T
G
G
G
C
A
G
C
G
G
A
A
A
C
G
T
T
C
A
T
T
T
C
C
G
A
T
G
G
T
G
A
T
C
A
C
T
T
G
C
T
0.056751
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0.046967
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0.021526
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0.048924
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0.041096
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0.039139
1
10,104
G
G
C
A
A
G
T
G
A
T
C
A
C
C
A
T
C
G
G
A
A
A
T
G
A
A
C
G
T
T
T
C
C
G
C
T
G
C
C
C
A
G
A
G
A
C
C
C
T
G
T
T
C
C
A
G
C
C
A
T
C
C
T
T
C
T
0.056751
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0.046967
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0.037182
0.041096
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0.015656
0.039139
1
10,105
A
G
T
C
A
G
T
G
A
G
A
T
C
T
C
G
G
C
C
A
G
C
C
A
G
A
T
C
C
A
G
A
C
G
C
A
T
G
A
T
G
G
C
A
T
G
G
G
G
C
A
A
G
G
C
A
T
A
G
C
C
C
T
C
A
A
0.035225
0.013699
0.039139
0.021526
0.031311
0.017613
0.009785
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0.046967
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0.019569
0.041096
1
10,106
A
G
T
C
A
G
T
G
A
G
A
T
C
T
C
G
G
C
C
A
G
C
C
A
G
A
T
C
C
A
G
A
C
G
C
A
T
G
A
T
G
G
C
A
T
G
G
G
G
C
A
A
G
G
C
A
T
A
G
C
C
C
T
C
A
T
0.035225
0.013699
0.039139
0.021526
0.031311
0.017613
0.009785
0.029354
0.04501
0.033268
0.046967
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0.048924
0.005871
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0.017613
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0.02544
0.021526
0.043053
0.043053
0.046967
0.011742
0.019569
0.041096
1
10,107
A
T
G
A
G
G
G
C
T
A
T
G
C
C
T
T
G
C
C
C
C
A
T
G
C
C
A
T
C
A
T
G
C
G
T
C
T
G
G
A
T
C
T
G
G
C
T
G
G
C
C
G
A
G
A
T
C
T
C
A
C
T
G
A
C
T
0.037182
0.013699
0.039139
0.021526
0.031311
0.017613
0.009785
0.029354
0.04501
0.033268
0.046967
0.015656
0.041096
0.054795
0.031311
0.041096
0.043053
0.054795
0.048924
0.005871
0.009785
0.005871
0.017613
0.054795
0.02544
0.021526
0.043053
0.043053
0.046967
0.011742
0.017613
0.041096
1
10,108
A
T
G
A
G
G
G
C
T
A
T
G
C
C
T
T
G
C
C
C
C
A
T
G
C
C
A
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C
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G
C
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A
T
C
T
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G
C
T
G
G
C
C
G
A
G
A
T
C
T
C
A
C
T
G
A
C
A
0.037182
0.013699
0.039139
0.021526
0.031311
0.017613
0.009785
0.029354
0.04501
0.033268
0.046967
0.015656
0.041096
0.054795
0.031311
0.041096
0.043053
0.054795
0.048924
0.005871
0.009785
0.005871
0.017613
0.054795
0.02544
0.021526
0.043053
0.043053
0.046967
0.011742
0.017613
0.041096
1
10,109
T
C
C
A
G
G
C
G
G
T
G
C
T
G
T
C
T
C
T
C
T
A
T
G
C
C
T
C
T
G
G
A
C
G
C
A
C
A
A
C
T
G
G
T
A
G
G
T
G
G
C
T
G
G
G
C
G
G
G
A
C
A
G
C
A
T
0.048924
0.035225
0.039139
0.021526
0.035225
0.029354
0.015656
0.02544
0.058708
0.035225
0.041096
0.013699
0.02544
0.033268
0.029354
0.033268
0.058708
0.052838
0.037182
0.009785
0.003914
0.009785
0.021526
0.041096
0.04501
0.027397
0.029354
0.035225
0.037182
0.009785
0.021526
0.039139
1
10,110
T
T
C
G
T
C
A
C
C
C
A
C
G
T
A
G
C
T
G
T
C
T
T
T
T
T
G
T
C
C
C
A
T
T
C
C
C
A
C
C
A
T
C
A
C
C
C
C
C
T
A
A
A
A
A
G
G
T
T
C
A
A
C
A
C
C
0.054795
0.041096
0.041096
0.043053
0.046967
0.02544
0.007828
0.035225
0.033268
0.031311
0.029354
0.023483
0.029354
0.04501
0.052838
0.029354
0.046967
0.043053
0.041096
0.001957
0.005871
0
0.009785
0.031311
0.039139
0.021526
0.035225
0.015656
0.033268
0.023483
0.033268
0.048924
1
10,111
C
A
A
T
C
C
C
T
T
G
G
A
G
T
T
G
A
T
G
T
C
A
G
T
C
A
C
T
T
G
G
G
C
A
T
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A
A
C
A
C
T
T
T
T
G
G
A
C
G
A
T
A
A
T
C
T
A
G
C
A
A
C
A
G
T
0.058708
0.04501
0.039139
0.043053
0.052838
0.017613
0.009785
0.048924
0.048924
0.019569
0.027397
0.039139
0.027397
0.031311
0.046967
0.031311
0.052838
0.037182
0.015656
0
0.001957
0
0.021526
0.031311
0.037182
0.023483
0.031311
0.019569
0.027397
0.029354
0.043053
0.041096
1
10,112
C
C
T
C
T
T
T
C
A
A
T
T
G
C
A
T
T
T
T
A
A
G
A
C
T
C
T
T
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C
C
A
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T
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C
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C
A
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A
C
A
A
T
C
T
A
C
A
T
C
T
T
C
T
G
C
A
T
C
0.050881
0.027397
0.046967
0.039139
0.048924
0.033268
0.003914
0.027397
0.046967
0.019569
0.058708
0.023483
0.015656
0.035225
0.037182
0.031311
0.041096
0.033268
0.046967
0.005871
0.001957
0.003914
0.041096
0.021526
0.052838
0.029354
0.031311
0.02544
0.039139
0.02544
0.023483
0.031311
1
10,113
A
T
C
T
G
C
A
C
T
T
G
G
T
A
T
T
C
T
G
G
G
T
C
C
G
G
G
T
G
C
A
G
T
T
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T
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T
C
C
A
C
T
T
C
T
A
A
G
C
C
T
A
G
A
A
A
A
T
C
A
G
T
T
C
0.068493
0.052838
0.033268
0.035225
0.041096
0.029354
0.003914
0.060665
0.039139
0.027397
0.02544
0.035225
0.021526
0.029354
0.035225
0.035225
0.054795
0.035225
0.019569
0.005871
0
0.001957
0.041096
0.023483
0.033268
0.02544
0.037182
0.011742
0.02544
0.019569
0.052838
0.039139
1
10,114
T
T
C
T
A
G
G
C
T
T
A
G
A
A
G
T
G
G
A
A
A
T
A
A
A
C
T
G
C
A
C
C
C
G
G
A
C
C
C
A
G
A
A
T
A
C
C
A
A
G
T
G
C
A
G
A
T
G
T
A
A
A
C
C
A
T
0.068493
0.052838
0.033268
0.035225
0.043053
0.031311
0.003914
0.060665
0.037182
0.027397
0.02544
0.035225
0.021526
0.029354
0.035225
0.039139
0.052838
0.035225
0.015656
0.005871
0
0.001957
0.043053
0.021526
0.033268
0.02544
0.037182
0.011742
0.023483
0.021526
0.052838
0.039139
1
10,115
C
T
A
C
A
G
G
A
T
C
C
A
G
A
T
C
T
A
A
C
T
T
G
G
G
G
T
G
G
C
T
T
T
G
T
C
T
T
C
T
T
C
T
T
T
T
G
C
C
A
A
T
T
C
C
A
C
T
A
A
T
T
G
T
T
C
0.09002
0.037182
0.058708
0.066536
0.031311
0.02544
0.001957
0.033268
0.046967
0.023483
0.023483
0.035225
0.031311
0.031311
0.060665
0.02544
0.023483
0.039139
0.027397
0.001957
0
0
0.02544
0.019569
0.054795
0.007828
0.031311
0.011742
0.027397
0.023483
0.04501
0.039139
1
10,116
C
T
T
T
C
G
A
A
C
A
A
A
G
C
C
T
T
T
A
A
C
T
T
G
A
C
T
T
A
G
T
G
T
C
A
T
G
A
C
T
C
C
A
G
C
A
A
T
A
G
T
G
G
T
G
A
T
A
T
A
T
T
T
A
C
G
0.088063
0.031311
0.052838
0.062622
0.037182
0.013699
0.003914
0.046967
0.056751
0.021526
0.017613
0.043053
0.02544
0.041096
0.050881
0.015656
0.031311
0.027397
0.009785
0
0.005871
0.001957
0.035225
0.023483
0.060665
0.033268
0.013699
0.009785
0.019569
0.021526
0.037182
0.060665
1
10,117
T
G
G
C
T
T
C
A
T
T
G
A
C
A
C
C
A
T
T
C
T
T
T
C
G
A
A
C
A
A
A
G
C
C
T
T
T
A
A
C
T
T
G
A
C
T
T
A
G
T
G
T
C
A
T
G
A
C
T
C
C
A
G
C
A
G
0.088063
0.029354
0.054795
0.060665
0.035225
0.011742
0.003914
0.048924
0.058708
0.021526
0.015656
0.041096
0.027397
0.043053
0.050881
0.015656
0.031311
0.027397
0.007828
0
0.005871
0.001957
0.035225
0.023483
0.066536
0.033268
0.013699
0.009785
0.021526
0.021526
0.029354
0.064579
1
10,118
C
A
T
C
T
A
T
T
T
T
G
G
C
T
T
C
A
T
T
G
A
C
A
C
C
A
T
T
C
T
T
T
C
G
A
A
C
A
A
A
G
C
C
T
T
T
A
A
C
T
T
G
A
C
T
T
A
G
T
G
T
C
A
T
G
G
0.09002
0.029354
0.058708
0.060665
0.035225
0.011742
0.003914
0.046967
0.058708
0.02544
0.015656
0.037182
0.027397
0.043053
0.052838
0.015656
0.029354
0.027397
0.005871
0
0.005871
0.001957
0.035225
0.023483
0.066536
0.035225
0.013699
0.009785
0.021526
0.017613
0.029354
0.064579
1
10,119
T
C
T
T
G
A
T
C
T
C
A
T
C
T
A
T
T
T
T
G
G
C
T
T
C
A
T
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G
A
C
A
C
C
A
T
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C
T
T
T
C
G
A
A
C
A
A
A
G
C
C
T
T
T
A
A
C
T
T
G
A
C
T
T
A
0.09002
0.029354
0.058708
0.060665
0.035225
0.011742
0.003914
0.048924
0.062622
0.02544
0.013699
0.035225
0.02544
0.041096
0.052838
0.017613
0.027397
0.02544
0.005871
0
0.005871
0.001957
0.039139
0.02544
0.068493
0.035225
0.011742
0.007828
0.019569
0.017613
0.029354
0.066536
1
10,120
G
T
C
A
T
T
C
T
T
G
A
T
C
T
C
A
T
C
T
A
T
T
T
T
G
G
C
T
T
C
A
T
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G
A
C
A
C
C
A
T
T
C
T
T
T
C
G
A
A
C
A
A
A
G
C
C
T
T
T
A
A
C
T
T
C
0.093933
0.031311
0.058708
0.058708
0.037182
0.011742
0.003914
0.048924
0.062622
0.02544
0.013699
0.035225
0.02544
0.041096
0.050881
0.017613
0.027397
0.023483
0.005871
0
0.005871
0.001957
0.039139
0.02544
0.068493
0.035225
0.011742
0.007828
0.017613
0.017613
0.029354
0.066536
1
10,121
A
G
G
C
T
T
T
G
T
T
C
G
A
A
A
G
A
A
T
G
G
T
G
T
C
A
A
T
G
A
A
G
C
C
A
A
A
A
T
A
G
A
T
G
A
G
A
T
C
A
A
G
A
A
T
G
A
C
A
A
T
G
T
C
C
A
0.09589
0.031311
0.058708
0.062622
0.039139
0.011742
0.003914
0.046967
0.060665
0.02544
0.013699
0.035225
0.02544
0.041096
0.054795
0.017613
0.027397
0.023483
0.005871
0
0.005871
0.001957
0.037182
0.023483
0.066536
0.035225
0.011742
0.007828
0.017613
0.017613
0.027397
0.066536
1
10,122
T
G
T
G
T
C
T
T
G
G
A
C
A
T
T
G
T
C
A
T
T
C
T
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G
A
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C
T
C
A
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C
T
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T
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G
G
C
T
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C
A
T
T
G
A
C
A
C
C
A
T
T
C
T
T
T
C
G
A
A
A
0.09589
0.031311
0.056751
0.062622
0.039139
0.009785
0.003914
0.046967
0.062622
0.02544
0.011742
0.035225
0.02544
0.041096
0.052838
0.017613
0.031311
0.023483
0.005871
0
0.005871
0.001957
0.037182
0.021526
0.07045
0.035225
0.011742
0.007828
0.017613
0.017613
0.027397
0.066536
1
10,123
C
T
G
T
G
T
C
T
T
G
G
A
C
A
T
T
G
T
C
A
T
T
C
T
T
G
A
T
C
T
C
A
T
C
T
A
T
T
T
T
G
G
C
T
T
C
A
T
T
G
A
C
A
C
C
A
T
T
C
T
T
T
C
G
A
A
0.09589
0.029354
0.056751
0.062622
0.039139
0.009785
0.003914
0.046967
0.062622
0.02544
0.011742
0.035225
0.02544
0.041096
0.052838
0.017613
0.031311
0.023483
0.005871
0
0.005871
0.001957
0.037182
0.021526
0.07045
0.035225
0.011742
0.007828
0.017613
0.017613
0.027397
0.068493
1
10,124
A
T
G
C
C
A
A
T
T
A
C
G
A
A
G
C
A
G
T
T
G
A
A
C
T
T
T
C
T
G
T
T
C
T
G
C
T
G
T
G
T
C
T
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G
G
A
C
A
T
T
G
T
C
A
T
T
C
T
T
G
A
T
C
T
T
0.099804
0.029354
0.056751
0.068493
0.035225
0.009785
0.003914
0.048924
0.060665
0.021526
0.009785
0.041096
0.027397
0.041096
0.052838
0.019569
0.027397
0.023483
0.001957
0
0.005871
0.001957
0.035225
0.021526
0.068493
0.031311
0.015656
0.007828
0.015656
0.017613
0.033268
0.066536
1
10,125
G
A
T
G
C
C
A
A
T
T
A
C
G
A
A
G
C
A
G
T
T
G
A
A
C
T
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T
C
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T
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C
T
G
C
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G
T
G
T
C
T
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G
G
A
C
A
T
T
G
T
C
A
T
T
C
T
T
G
A
T
C
C
0.099804
0.029354
0.056751
0.068493
0.035225
0.009785
0.003914
0.048924
0.060665
0.021526
0.009785
0.039139
0.027397
0.041096
0.052838
0.019569
0.027397
0.023483
0.001957
0
0.005871
0.001957
0.037182
0.021526
0.068493
0.031311
0.015656
0.007828
0.015656
0.017613
0.033268
0.066536
1
10,126
G
T
C
G
T
A
G
A
C
A
T
C
T
G
C
A
A
G
C
C
A
G
T
C
G
T
G
A
C
C
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C
G
C
T
C
C
A
G
A
C
T
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C
A
G
T
C
G
G
C
A
C
A
A
G
C
A
T
G
T
C
C
T
G
0.076321
0.031311
0.041096
0.060665
0.048924
0.015656
0.009785
0.035225
0.043053
0.027397
0.015656
0.02544
0.029354
0.048924
0.054795
0.027397
0.027397
0.033268
0.021526
0.011742
0.007828
0.005871
0.017613
0.033268
0.033268
0.031311
0.027397
0.017613
0.027397
0.019569
0.04501
0.048924
1
10,127
A
T
G
A
A
C
C
C
C
A
A
A
T
G
C
A
C
T
C
C
T
G
G
A
A
T
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C
C
T
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C
C
T
G
G
C
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C
C
A
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T
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T
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A
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A
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G
T
T
T
T
G
C
A
C
A
G
A
A
G
T
G
0.09589
0.037182
0.031311
0.04501
0.058708
0.027397
0.005871
0.02544
0.041096
0.019569
0.033268
0.041096
0.023483
0.046967
0.046967
0.035225
0.039139
0.035225
0.031311
0
0.001957
0
0.021526
0.027397
0.039139
0.015656
0.039139
0.015656
0.02544
0.031311
0.027397
0.035225
1
10,128
G
C
C
G
G
G
C
C
T
T
G
A
T
T
T
T
T
T
G
G
C
G
G
G
G
A
C
C
G
T
C
A
T
G
G
C
G
T
C
G
C
A
G
C
C
A
A
A
T
T
C
G
T
C
T
G
C
G
A
A
G
A
A
G
A
C
0.043053
0.019569
0.019569
0.02544
0.021526
0.033268
0.023483
0.013699
0.041096
0.027397
0.04501
0.005871
0.015656
0.013699
0.021526
0.023483
0.048924
0.043053
0.064579
0.056751
0.02544
0.062622
0.011742
0.046967
0.033268
0.037182
0.02544
0.060665
0.050881
0.011742
0.009785
0.017613
1
10,129
G
T
C
T
G
G
C
C
A
C
A
G
A
C
G
T
G
A
A
C
T
T
T
G
A
C
C
A
C
A
G
G
C
C
T
T
A
T
G
T
T
G
T
T
A
C
C
A
C
T
T
A
A
C
T
G
T
C
G
G
C
C
C
T
C
A
0.037182
0.043053
0.041096
0.015656
0.039139
0.050881
0.013699
0.02544
0.031311
0.031311
0.052838
0.011742
0.027397
0.027397
0.039139
0.052838
0.043053
0.056751
0.050881
0.009785
0.005871
0.005871
0.023483
0.033268
0.039139
0.021526
0.027397
0.02544
0.043053
0.011742
0.023483
0.039139
1
10,130
A
C
C
A
C
T
G
G
A
T
C
G
T
C
G
A
C
A
C
A
G
A
C
T
A
C
G
A
C
A
C
G
T
A
T
G
C
C
G
T
G
C
A
G
T
A
C
T
C
C
T
G
C
C
G
C
C
T
C
C
T
G
A
A
C
A
0.046967
0.019569
0.039139
0.023483
0.031311
0.019569
0.023483
0.031311
0.039139
0.033268
0.052838
0.009785
0.029354
0.019569
0.023483
0.039139
0.074364
0.041096
0.029354
0.017613
0.021526
0.007828
0.011742
0.033268
0.04501
0.031311
0.046967
0.052838
0.039139
0.015656
0.013699
0.037182
1
10,131
A
C
T
T
G
G
C
A
G
G
G
T
C
C
T
C
G
G
T
G
T
C
T
G
T
G
A
A
G
G
T
G
C
C
C
A
C
C
A
T
G
T
C
T
G
C
G
C
A
C
A
C
G
T
C
C
C
A
G
T
T
A
C
T
G
T
0.021526
0.013699
0.050881
0.011742
0.019569
0.037182
0.015656
0.02544
0.031311
0.037182
0.062622
0
0.015656
0.015656
0.029354
0.037182
0.054795
0.056751
0.068493
0.031311
0.011742
0.031311
0.015656
0.037182
0.041096
0.027397
0.035225
0.060665
0.052838
0.019569
0.005871
0.02544
1
10,132
C
T
T
C
A
A
A
A
G
A
C
G
G
A
C
T
C
G
G
C
C
C
T
T
G
G
C
T
G
T
G
G
C
G
C
T
C
A
T
C
T
G
G
C
C
G
G
T
C
T
C
G
T
C
C
A
C
G
G
A
G
A
A
C
T
T
0.015656
0.013699
0.041096
0.003914
0.021526
0.029354
0.023483
0.017613
0.02544
0.029354
0.060665
0.001957
0.017613
0.019569
0.027397
0.033268
0.050881
0.052838
0.091977
0.046967
0.02544
0.04501
0.001957
0.039139
0.029354
0.035225
0.035225
0.082192
0.050881
0.009785
0.001957
0.019569
1
10,133
T
A
G
A
G
G
C
C
A
C
C
T
C
A
G
G
T
A
T
G
C
C
G
T
T
C
C
G
G
G
A
C
C
G
G
C
A
C
A
G
G
A
A
C
A
T
G
C
T
G
C
A
G
C
G
G
T
C
A
G
C
C
T
G
G
T
0.02544
0.027397
0.029354
0.009785
0.037182
0.04501
0.005871
0.02544
0.031311
0.039139
0.068493
0.011742
0.011742
0.02544
0.033268
0.04501
0.074364
0.060665
0.060665
0.015656
0.001957
0.003914
0.011742
0.046967
0.029354
0.033268
0.046967
0.043053
0.054795
0.007828
0.003914
0.033268
1
10,134
G
A
C
C
T
C
T
G
C
C
C
C
A
C
T
G
T
C
A
T
A
A
G
G
C
C
A
C
C
T
A
C
C
T
T
T
T
T
C
A
C
A
T
C
T
G
G
G
A
C
A
T
T
A
T
G
A
G
T
T
T
T
C
T
T
A
0.043053
0.037182
0.029354
0.037182
0.039139
0.037182
0.003914
0.027397
0.027397
0.021526
0.052838
0.02544
0.015656
0.035225
0.043053
0.039139
0.052838
0.054795
0.060665
0.015656
0.001957
0.001957
0.019569
0.027397
0.039139
0.021526
0.039139
0.046967
0.037182
0.009785
0.019569
0.037182
1
10,135
G
C
C
T
C
C
A
A
C
C
A
G
A
T
G
C
C
C
A
G
G
G
T
T
A
G
C
A
T
T
A
C
C
T
C
T
T
C
A
T
C
C
T
G
T
T
T
G
G
A
A
A
A
T
T
C
A
G
A
T
G
C
A
T
T
G
0.056751
0.033268
0.041096
0.041096
0.048924
0.033268
0.003914
0.021526
0.050881
0.027397
0.033268
0.027397
0.037182
0.054795
0.04501
0.023483
0.046967
0.041096
0.017613
0.007828
0.005871
0.001957
0.02544
0.023483
0.041096
0.027397
0.031311
0.02544
0.023483
0.023483
0.029354
0.048924
1
10,136
C
T
T
A
G
G
A
A
G
T
C
A
A
C
T
T
T
T
A
T
A
A
A
A
T
C
A
T
T
G
A
T
T
A
C
A
T
T
T
T
A
C
A
T
G
G
A
A
A
A
G
A
A
G
A
G
A
T
C
A
A
A
G
T
G
A
0.107632
0.041096
0.043053
0.084149
0.037182
0.009785
0.005871
0.035225
0.037182
0.007828
0.017613
0.080235
0.023483
0.037182
0.058708
0.015656
0.021526
0.029354
0.015656
0.005871
0
0.003914
0.015656
0.017613
0.04501
0.009785
0.037182
0.013699
0.029354
0.021526
0.062622
0.029354
1
10,137
T
T
C
A
G
G
A
G
T
G
G
C
T
T
T
G
G
T
T
T
G
G
T
T
C
A
T
G
A
G
C
A
T
T
T
C
C
T
G
A
G
C
A
A
T
G
T
C
C
T
T
T
C
T
G
T
T
T
T
C
T
A
G
C
T
C
0.064579
0.021526
0.050881
0.058708
0.035225
0.031311
0.003914
0.02544
0.064579
0.02544
0.031311
0.023483
0.027397
0.043053
0.031311
0.023483
0.043053
0.052838
0.02544
0
0.001957
0.001957
0.021526
0.033268
0.056751
0.027397
0.015656
0.011742
0.041096
0.023483
0.04501
0.037182
1
10,138
A
C
A
A
A
T
T
A
T
T
G
G
T
G
C
C
T
C
T
G
T
G
G
T
C
A
A
T
A
T
C
A
T
G
G
C
A
G
A
A
A
G
C
A
G
C
A
G
C
A
A
G
C
A
T
G
G
C
A
A
A
G
G
C
T
A
0.046967
0.02544
0.058708
0.050881
0.041096
0.023483
0.013699
0.031311
0.04501
0.023483
0.041096
0.054795
0.015656
0.031311
0.04501
0.035225
0.031311
0.039139
0.023483
0.001957
0.005871
0.005871
0.027397
0.023483
0.056751
0.017613
0.035225
0.02544
0.033268
0.031311
0.031311
0.027397
1
10,139
A
G
G
T
G
T
G
A
T
T
T
C
T
T
T
G
T
G
A
A
A
C
C
G
T
G
A
G
A
A
C
T
C
C
T
A
A
A
A
G
G
A
A
T
T
T
T
A
G
G
T
C
A
G
A
A
A
C
T
A
C
A
T
A
A
T
0.074364
0.035225
0.04501
0.033268
0.037182
0.021526
0.007828
0.031311
0.046967
0.046967
0.048924
0.021526
0.023483
0.039139
0.021526
0.031311
0.048924
0.019569
0.013699
0.005871
0.003914
0.001957
0.031311
0.046967
0.050881
0.013699
0.029354
0.023483
0.029354
0.019569
0.041096
0.054795
1
10,140
A
G
A
A
A
C
C
A
G
C
G
A
A
G
C
C
A
A
A
A
T
G
C
C
C
T
G
C
C
G
T
G
T
G
T
A
C
T
T
G
T
A
C
C
A
A
A
G
A
T
A
A
T
G
C
T
T
T
A
T
G
T
G
A
G
C
0.076321
0.013699
0.04501
0.058708
0.031311
0.015656
0.009785
0.009785
0.056751
0.037182
0.033268
0.02544
0.035225
0.052838
0.037182
0.019569
0.043053
0.037182
0.027397
0.009785
0.007828
0.007828
0.017613
0.031311
0.048924
0.013699
0.056751
0.027397
0.037182
0.019569
0.029354
0.027397
1
10,141
G
A
C
A
A
A
A
A
A
T
A
T
T
A
T
A
A
C
T
T
A
T
T
G
C
A
G
A
T
T
C
A
T
A
G
A
A
A
A
C
A
A
C
A
A
C
A
T
C
A
A
G
T
C
A
A
T
T
T
C
A
A
G
A
C
A
0.093933
0.031311
0.050881
0.060665
0.050881
0.015656
0
0.048924
0.037182
0.017613
0.015656
0.033268
0.037182
0.052838
0.050881
0.029354
0.031311
0.021526
0.011742
0.003914
0.003914
0
0.015656
0.021526
0.037182
0.027397
0.027397
0.005871
0.019569
0.027397
0.056751
0.062622
1
10,142
A
C
A
A
C
A
T
C
A
A
G
T
C
A
A
T
T
T
C
A
A
G
A
C
A
T
A
C
T
T
T
C
C
G
G
G
G
A
C
T
A
A
A
G
T
C
A
T
T
A
A
T
T
C
A
C
T
T
G
T
A
A
G
T
A
T
0.097847
0.035225
0.048924
0.064579
0.050881
0.019569
0
0.046967
0.033268
0.015656
0.015656
0.037182
0.035225
0.050881
0.052838
0.029354
0.027397
0.02544
0.011742
0.003914
0.003914
0
0.019569
0.015656
0.037182
0.02544
0.027397
0.003914
0.021526
0.027397
0.058708
0.056751
1
10,143
T
A
T
T
T
T
T
G
C
A
G
A
A
T
T
T
G
C
A
A
A
G
T
C
T
C
A
A
G
A
C
C
T
G
C
C
T
T
A
T
C
A
A
T
C
A
T
T
G
T
C
C
A
T
A
G
A
C
A
C
T
T
T
T
T
C
0.117417
0.019569
0.050881
0.076321
0.029354
0.017613
0
0.031311
0.029354
0.029354
0.031311
0.050881
0.019569
0.054795
0.039139
0.015656
0.023483
0.02544
0.009785
0.003914
0.001957
0.001957
0.027397
0.019569
0.048924
0.017613
0.029354
0.017613
0.02544
0.027397
0.058708
0.048924
1
10,144
C
A
T
C
T
A
T
A
A
G
C
G
A
G
A
C
A
G
T
T
T
T
G
C
A
A
A
T
A
A
A
T
T
C
A
T
A
A
A
A
A
T
C
C
A
G
G
A
T
A
T
T
G
A
A
A
T
T
C
T
C
A
A
A
A
G
0.068493
0.041096
0.02544
0.050881
0.054795
0.019569
0.009785
0.031311
0.043053
0.027397
0.02544
0.029354
0.033268
0.039139
0.054795
0.027397
0.041096
0.046967
0.017613
0.007828
0.003914
0.009785
0.027397
0.033268
0.039139
0.019569
0.017613
0.027397
0.035225
0.02544
0.023483
0.043053
1
10,145
C
A
A
A
A
T
C
C
G
A
A
A
A
C
C
C
A
A
T
G
A
C
A
T
T
G
A
A
A
C
A
T
T
C
A
A
G
A
T
T
G
A
A
A
A
C
A
A
C
T
G
G
T
A
C
T
T
T
G
T
T
G
T
T
G
C
0.068493
0.04501
0.019569
0.056751
0.060665
0.015656
0.011742
0.037182
0.035225
0.027397
0.019569
0.033268
0.027397
0.039139
0.052838
0.031311
0.041096
0.04501
0.017613
0.007828
0.003914
0.011742
0.029354
0.027397
0.041096
0.019569
0.017613
0.021526
0.035225
0.029354
0.029354
0.041096
1
10,146
G
T
G
T
C
T
G
A
G
G
T
G
T
T
C
T
G
A
C
T
A
T
T
T
C
T
A
G
A
T
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T
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C
C
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C
A
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T
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C
C
C
T
G
T
A
C
C
A
C
G
C
G
T
G
T
A
A
G
G
0.064579
0.041096
0.023483
0.066536
0.056751
0.017613
0.019569
0.035225
0.029354
0.023483
0.023483
0.02544
0.029354
0.037182
0.050881
0.035225
0.041096
0.041096
0.017613
0.005871
0.005871
0.011742
0.021526
0.02544
0.052838
0.023483
0.013699
0.009785
0.043053
0.029354
0.02544
0.052838
1
10,147
C
T
T
C
A
T
C
A
A
C
T
C
T
G
A
C
C
T
G
C
C
A
A
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C
A
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C
A
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T
C
G
A
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T
G
A
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A
A
C
C
A
C
T
G
T
T
C
A
T
T
G
C
C
T
C
A
G
C
A
A
C
T
0.068493
0.039139
0.031311
0.037182
0.035225
0.027397
0.003914
0.031311
0.046967
0.035225
0.039139
0.02544
0.027397
0.039139
0.062622
0.023483
0.052838
0.039139
0.009785
0.001957
0.015656
0.005871
0.013699
0.054795
0.029354
0.021526
0.04501
0.039139
0.013699
0.013699
0.013699
0.056751
1
10,148
T
A
T
G
A
C
A
T
C
T
A
T
C
C
T
G
G
G
C
C
T
G
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A
G
T
T
A
A
A
A
A
G
A
A
A
A
A
T
A
A
T
A
C
0.109589
0.046967
0.039139
0.062622
0.052838
0.011742
0.003914
0.037182
0.031311
0.019569
0.021526
0.054795
0.041096
0.033268
0.037182
0.027397
0.031311
0.031311
0.013699
0.005871
0.011742
0.001957
0.023483
0.013699
0.031311
0.017613
0.013699
0.019569
0.027397
0.013699
0.080235
0.033268
1
10,149
T
A
A
T
G
G
A
A
A
A
G
T
T
G
A
A
T
G
A
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G
G
A
T
C
C
A
G
G
T
A
A
G
G
C
C
A
A
G
A
G
0.101761
0.027397
0.043053
0.072407
0.031311
0.009785
0.005871
0.023483
0.041096
0.031311
0.031311
0.046967
0.043053
0.033268
0.041096
0.017613
0.039139
0.033268
0.029354
0.001957
0
0
0.02544
0.019569
0.039139
0.007828
0.027397
0.027397
0.029354
0.017613
0.062622
0.039139
1
10,150
A
T
T
T
C
T
C
A
G
A
G
C
A
T
G
G
A
A
G
T
T
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A
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C
C
T
A
T
T
C
C
T
C
A
G
A
G
A
A
A
C
A
C
C
T
0.066536
0.021526
0.050881
0.019569
0.021526
0.029354
0.011742
0.035225
0.052838
0.046967
0.043053
0.013699
0.017613
0.023483
0.019569
0.027397
0.060665
0.046967
0.04501
0.011742
0.005871
0.005871
0.017613
0.048924
0.048924
0.02544
0.031311
0.021526
0.050881
0.023483
0.023483
0.031311
1
10,151
T
A
G
T
A
A
G
C
A
G
T
C
C
C
T
C
A
A
G
T
C
C
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G
G
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T
C
G
A
T
G
T
A
C
T
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A
T
T
C
C
C
A
C
T
T
0.048924
0.027397
0.04501
0.019569
0.031311
0.027397
0.011742
0.035225
0.052838
0.037182
0.046967
0.013699
0.023483
0.033268
0.015656
0.031311
0.054795
0.041096
0.046967
0.009785
0.011742
0.005871
0.015656
0.056751
0.056751
0.023483
0.021526
0.013699
0.056751
0.023483
0.021526
0.039139
1
10,152
C
A
A
T
G
C
A
T
A
A
T
T
C
C
A
G
G
T
C
C
C
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C
T
T
C
G
G
A
G
G
G
G
C
T
G
A
A
G
G
T
C
A
0.043053
0.033268
0.035225
0.02544
0.039139
0.019569
0.009785
0.04501
0.023483
0.033268
0.046967
0.017613
0.023483
0.043053
0.039139
0.029354
0.058708
0.046967
0.037182
0.009785
0.005871
0.001957
0.02544
0.029354
0.037182
0.027397
0.043053
0.039139
0.046967
0.02544
0.017613
0.041096
1
10,153
G
A
C
A
C
C
A
T
T
A
T
T
T
G
A
C
C
A
G
A
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G
G
T
A
A
G
A
G
T
T
C
C
A
T
A
G
G
A
C
T
C
0.046967
0.029354
0.041096
0.04501
0.058708
0.027397
0.001957
0.033268
0.048924
0.033268
0.031311
0.041096
0.029354
0.039139
0.033268
0.039139
0.04501
0.043053
0.013699
0.007828
0.005871
0
0.027397
0.033268
0.039139
0.023483
0.023483
0.017613
0.037182
0.029354
0.043053
0.031311
1
10,154
G
T
G
C
A
G
C
C
T
C
C
T
T
C
C
C
T
C
C
T
T
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A
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C
G
A
T
A
G
C
C
A
A
A
G
C
T
G
C
C
A
C
C
A
0.033268
0.023483
0.050881
0.021526
0.04501
0.015656
0.001957
0.04501
0.035225
0.041096
0.058708
0.009785
0.029354
0.021526
0.041096
0.048924
0.062622
0.037182
0.029354
0.007828
0.003914
0.001957
0.023483
0.043053
0.027397
0.019569
0.050881
0.048924
0.039139
0.013699
0.027397
0.041096
1
10,155
C
A
G
T
C
G
G
G
C
A
G
C
C
A
G
G
C
T
A
T
C
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G
A
A
T
G
C
A
G
A
T
T
A
A
A
A
A
G
T
C
A
G
0.088063
0.029354
0.048924
0.029354
0.043053
0.015656
0.001957
0.031311
0.050881
0.041096
0.029354
0.033268
0.033268
0.052838
0.037182
0.02544
0.04501
0.031311
0.019569
0.003914
0.003914
0.001957
0.033268
0.027397
0.039139
0.021526
0.039139
0.031311
0.017613
0.015656
0.031311
0.046967
1
10,156
C
A
T
C
A
G
C
C
C
A
C
T
C
T
G
T
C
C
G
G
C
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G
A
C
T
G
G
A
A
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T
G
C
C
T
G
T
A
A
T
A
A
0.037182
0.017613
0.039139
0.02544
0.039139
0.031311
0.007828
0.021526
0.050881
0.04501
0.043053
0.015656
0.027397
0.035225
0.033268
0.04501
0.066536
0.052838
0.037182
0.009785
0.003914
0.009785
0.011742
0.043053
0.043053
0.019569
0.043053
0.043053
0.031311
0.017613
0.005871
0.046967
1
10,157
T
C
A
G
C
T
G
G
T
T
C
T
G
C
C
C
C
G
A
G
T
G
G
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C
C
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G
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C
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A
C
A
G
A
A
G
G
A
T
C
T
C
A
T
G
G
C
G
C
A
0.02544
0.013699
0.037182
0.02544
0.033268
0.031311
0.009785
0.021526
0.052838
0.048924
0.043053
0.015656
0.031311
0.039139
0.02544
0.037182
0.07045
0.052838
0.037182
0.011742
0.007828
0.009785
0.013699
0.04501
0.039139
0.015656
0.04501
0.048924
0.029354
0.029354
0.011742
0.041096
1
10,158
T
C
A
G
C
T
G
G
T
T
C
T
G
C
C
C
C
G
A
G
T
G
G
A
G
G
G
C
C
T
G
C
C
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C
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C
G
C
T
C
T
G
A
G
A
C
A
G
A
A
G
G
A
T
C
T
C
A
T
G
G
C
G
C
T
0.02544
0.013699
0.037182
0.02544
0.033268
0.031311
0.009785
0.021526
0.052838
0.048924
0.043053
0.015656
0.031311
0.039139
0.02544
0.037182
0.07045
0.052838
0.037182
0.011742
0.007828
0.009785
0.013699
0.04501
0.039139
0.015656
0.04501
0.048924
0.029354
0.029354
0.011742
0.041096
1
10,159
T
G
C
G
C
C
A
T
G
A
G
A
T
C
C
T
T
C
T
G
T
C
T
C
A
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A
G
C
G
T
G
C
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C
C
C
T
C
C
A
C
T
C
G
G
G
G
C
A
G
A
A
C
C
A
G
C
T
G
T
0.02544
0.013699
0.037182
0.023483
0.033268
0.031311
0.009785
0.021526
0.052838
0.048924
0.043053
0.015656
0.031311
0.039139
0.02544
0.037182
0.07045
0.054795
0.037182
0.011742
0.007828
0.009785
0.013699
0.04501
0.039139
0.015656
0.04501
0.048924
0.029354
0.029354
0.011742
0.041096
1
10,160
C
A
A
A
C
A
A
C
G
C
T
T
G
C
G
C
C
A
T
G
A
G
A
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C
C
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T
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C
G
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G
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G
G
C
A
G
G
C
C
C
T
C
C
A
C
T
C
G
G
G
G
C
T
0.02544
0.013699
0.035225
0.02544
0.033268
0.033268
0.009785
0.021526
0.054795
0.046967
0.043053
0.015656
0.033268
0.039139
0.02544
0.037182
0.07045
0.054795
0.035225
0.011742
0.007828
0.009785
0.013699
0.04501
0.037182
0.015656
0.04501
0.046967
0.029354
0.031311
0.013699
0.039139
1
10,161
C
A
G
A
G
A
G
A
T
G
A
T
G
C
T
G
G
T
G
A
C
C
A
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G
G
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C
G
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G
C
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A
A
C
A
A
C
G
C
T
T
G
C
G
C
C
A
T
G
A
G
A
C
0.031311
0.013699
0.035225
0.033268
0.035225
0.029354
0.009785
0.019569
0.056751
0.043053
0.04501
0.015656
0.035225
0.037182
0.027397
0.035225
0.066536
0.050881
0.031311
0.011742
0.007828
0.009785
0.019569
0.043053
0.041096
0.017613
0.041096
0.043053
0.033268
0.027397
0.013699
0.039139
1
10,162
T
A
C
C
T
G
A
G
A
A
A
C
T
A
C
A
T
T
C
T
G
A
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A
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T
G
T
T
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C
C
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G
A
G
C
A
T
T
A
G
C
C
T
G
T
G
A
G
G
T
A
A
T
0.054795
0.052838
0.046967
0.058708
0.043053
0.023483
0.003914
0.046967
0.056751
0.017613
0.029354
0.029354
0.023483
0.023483
0.062622
0.021526
0.039139
0.031311
0.013699
0.001957
0.003914
0.001957
0.031311
0.033268
0.054795
0.015656
0.029354
0.013699
0.02544
0.027397
0.041096
0.041096
1
10,163
C
T
A
C
G
T
C
G
G
A
C
C
C
G
G
A
G
G
C
C
C
T
G
A
A
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G
C
C
C
C
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T
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C
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G
C
T
C
G
C
G
C
T
C
C
T
G
C
A
A
G
T
G
T
G
0.007828
0.019569
0.02544
0.011742
0.015656
0.02544
0.033268
0.027397
0.033268
0.029354
0.058708
0.003914
0.011742
0.023483
0.021526
0.033268
0.048924
0.04501
0.064579
0.043053
0.027397
0.04501
0.009785
0.064579
0.029354
0.039139
0.039139
0.062622
0.058708
0.007828
0.005871
0.027397
1
10,164
C
T
A
C
G
T
C
G
G
A
C
C
C
G
G
A
G
G
C
C
C
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G
C
T
C
G
C
G
C
T
C
C
T
G
C
A
A
G
T
G
T
C
0.007828
0.019569
0.02544
0.011742
0.015656
0.02544
0.033268
0.027397
0.033268
0.029354
0.058708
0.003914
0.011742
0.023483
0.021526
0.033268
0.048924
0.04501
0.064579
0.043053
0.027397
0.04501
0.009785
0.064579
0.029354
0.039139
0.039139
0.062622
0.058708
0.007828
0.005871
0.027397
1
10,165
T
T
G
T
G
T
A
G
A
G
G
C
T
C
C
C
C
C
A
A
G
G
T
C
C
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A
A
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C
T
C
C
A
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T
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C
C
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G
A
T
T
A
T
T
G
G
T
T
T
C
A
T
A
T
G
G
G
A
T
0.048924
0.023483
0.046967
0.021526
0.04501
0.023483
0
0.035225
0.052838
0.035225
0.048924
0.035225
0.027397
0.029354
0.043053
0.027397
0.054795
0.039139
0.041096
0.003914
0.005871
0.001957
0.035225
0.033268
0.035225
0.031311
0.037182
0.031311
0.037182
0.021526
0.013699
0.033268
1
10,166
C
G
G
C
A
C
C
T
A
C
A
C
C
C
G
C
C
A
C
G
G
C
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A
C
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T
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C
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C
T
G
T
C
T
G
A
T
G
A
A
G
A
G
C
A
G
C
G
T
0.035225
0.023483
0.041096
0.009785
0.035225
0.02544
0.021526
0.027397
0.037182
0.046967
0.037182
0.005871
0.02544
0.029354
0.023483
0.039139
0.050881
0.035225
0.039139
0.039139
0.021526
0.039139
0.027397
0.029354
0.033268
0.023483
0.048924
0.056751
0.027397
0.023483
0.017613
0.023483
1
10,167
A
G
A
C
C
A
A
T
T
G
T
G
C
T
T
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A
G
T
C
T
G
G
T
C
T
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T
G
T
G
A
G
G
C
G
0.017613
0.019569
0.031311
0.019569
0.033268
0.035225
0
0.031311
0.048924
0.023483
0.066536
0.017613
0.015656
0.017613
0.023483
0.041096
0.07045
0.058708
0.101761
0.005871
0.001957
0.003914
0.029354
0.041096
0.031311
0.031311
0.035225
0.054795
0.043053
0.007828
0.015656
0.02544
1
10,168
T
G
C
C
T
C
A
C
A
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A
A
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A
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C
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G
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T
T
G
G
T
C
A
0.017613
0.019569
0.031311
0.019569
0.033268
0.035225
0
0.031311
0.048924
0.023483
0.068493
0.017613
0.015656
0.017613
0.023483
0.041096
0.07045
0.058708
0.101761
0.005871
0.001957
0.003914
0.027397
0.041096
0.031311
0.031311
0.035225
0.054795
0.043053
0.007828
0.015656
0.02544
1
10,169
C
A
T
T
G
C
G
G
G
T
A
T
C
T
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A
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G
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A
C
T
A
T
G
G
G
A
T
0.023483
0.015656
0.035225
0.023483
0.037182
0.037182
0
0.037182
0.052838
0.021526
0.064579
0.013699
0.013699
0.019569
0.023483
0.035225
0.07045
0.052838
0.084149
0.005871
0.001957
0.003914
0.021526
0.050881
0.029354
0.04501
0.029354
0.031311
0.054795
0.013699
0.021526
0.029354
1
10,170
C
C
A
G
G
T
C
C
C
A
C
A
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A
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A
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A
T
T
C
G
0.017613
0.015656
0.037182
0.013699
0.039139
0.043053
0.001957
0.033268
0.046967
0.037182
0.068493
0.011742
0.009785
0.015656
0.015656
0.041096
0.082192
0.058708
0.078278
0.003914
0.001957
0.003914
0.013699
0.050881
0.02544
0.043053
0.031311
0.033268
0.054795
0.019569
0.02544
0.02544
1
10,171
G
T
A
C
A
G
T
G
T
C
C
C
A
G
C
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A
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T
G
G
T
C
A
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T
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C
C
C
A
G
C
C
0.02544
0.007828
0.031311
0.013699
0.037182
0.031311
0.007828
0.021526
0.04501
0.052838
0.048924
0.013699
0.019569
0.023483
0.023483
0.056751
0.072407
0.066536
0.068493
0.013699
0.005871
0.011742
0.007828
0.056751
0.02544
0.02544
0.048924
0.046967
0.050881
0.009785
0.003914
0.02544
1
10,172
T
A
G
C
T
G
G
C
C
A
T
C
A
G
A
A
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T
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C
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G
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T
T
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T
G
G
0.029354
0.019569
0.033268
0.019569
0.033268
0.039139
0.007828
0.017613
0.052838
0.050881
0.04501
0.003914
0.035225
0.023483
0.035225
0.043053
0.074364
0.064579
0.041096
0.019569
0.007828
0.007828
0.005871
0.050881
0.031311
0.017613
0.035225
0.058708
0.031311
0.015656
0.005871
0.043053
1
10,173
T
G
C
A
G
G
A
G
C
T
G
T
G
G
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G
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T
C
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G
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C
C
A
G
C
T
G
G
A
0.021526
0.009785
0.02544
0.021526
0.029354
0.017613
0.009785
0.02544
0.046967
0.052838
0.04501
0.013699
0.017613
0.029354
0.023483
0.037182
0.088063
0.058708
0.068493
0.013699
0.003914
0.027397
0.007828
0.048924
0.029354
0.02544
0.054795
0.060665
0.039139
0.009785
0.003914
0.033268
1
10,174
T
C
G
C
T
C
C
A
G
C
T
G
G
C
A
C
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C
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A
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C
A
C
A
G
C
T
C
T
0.021526
0.009785
0.02544
0.021526
0.031311
0.017613
0.009785
0.027397
0.046967
0.050881
0.04501
0.013699
0.017613
0.029354
0.023483
0.039139
0.086106
0.058708
0.066536
0.013699
0.003914
0.027397
0.007828
0.048924
0.029354
0.027397
0.054795
0.058708
0.039139
0.009785
0.003914
0.033268
1
10,175
G
T
C
T
C
T
T
C
T
A
A
C
A
G
G
C
C
C
T
G
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A
T
C
C
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A
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G
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C
T
G
A
A
G
A
A
A
A
T
0.043053
0.019569
0.031311
0.023483
0.015656
0.02544
0.001957
0.02544
0.046967
0.043053
0.058708
0.011742
0.02544
0.02544
0.029354
0.019569
0.074364
0.048924
0.060665
0.017613
0.003914
0.019569
0.015656
0.052838
0.035225
0.015656
0.050881
0.054795
0.046967
0.013699
0.009785
0.033268
1
10,176
G
C
G
C
T
T
T
G
G
G
A
T
C
C
C
A
G
G
G
C
T
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C
T
A
C
T
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T
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G
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G
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C
C
C
C
T
G
C
C
C
0.033268
0.017613
0.027397
0.021526
0.017613
0.02544
0.001957
0.023483
0.043053
0.046967
0.062622
0.013699
0.02544
0.02544
0.029354
0.019569
0.082192
0.050881
0.060665
0.017613
0.003914
0.019569
0.015656
0.052838
0.029354
0.017613
0.054795
0.058708
0.046967
0.013699
0.007828
0.033268
1
10,177
A
G
C
C
A
T
G
G
A
C
C
C
T
G
C
C
T
G
C
C
C
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A
A
A
T
C
C
A
T
G
C
G
C
A
G
T
G
C
C
T
C
C
T
T
0.029354
0.015656
0.033268
0.011742
0.017613
0.021526
0.005871
0.021526
0.041096
0.04501
0.072407
0.013699
0.02544
0.027397
0.021526
0.023483
0.080235
0.04501
0.060665
0.019569
0.003914
0.021526
0.015656
0.052838
0.033268
0.021526
0.052838
0.064579
0.050881
0.005871
0.007828
0.037182
1
10,178
A
T
T
G
T
T
T
C
C
T
C
C
T
G
C
T
T
T
C
C
T
C
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G
G
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C
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C
A
C
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G
C
C
A
G
G
G
G
A
A
G
G
A
G
C
T
G
G
T
G
T
0.013699
0.019569
0.031311
0.009785
0.033268
0.023483
0.011742
0.02544
0.037182
0.062622
0.074364
0.001957
0.023483
0.011742
0.019569
0.037182
0.080235
0.043053
0.056751
0.015656
0.011742
0.011742
0.015656
0.072407
0.027397
0.029354
0.035225
0.039139
0.07045
0.007828
0.013699
0.033268
1
10,179
C
C
T
G
C
G
C
C
C
G
G
C
C
G
A
C
C
T
G
C
T
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C
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C
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C
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G
G
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C
A
G
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A
C
C
T
C
T
A
C
C
C
C
A
G
C
G
A
G
A
G
C
A
C
0.04501
0.021526
0.031311
0.033268
0.035225
0.029354
0.007828
0.027397
0.039139
0.033268
0.056751
0.007828
0.011742
0.033268
0.02544
0.039139
0.07045
0.052838
0.056751
0.007828
0.007828
0.007828
0.011742
0.043053
0.035225
0.023483
0.050881
0.048924
0.039139
0.013699
0.02544
0.027397
1
10,180
G
C
C
T
G
C
T
G
T
G
G
A
C
C
T
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C
A
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C
G
C
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G
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G
A
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T
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A
C
T
A
C
T
T
0.033268
0.021526
0.031311
0.011742
0.035225
0.035225
0.007828
0.023483
0.037182
0.060665
0.04501
0.013699
0.013699
0.027397
0.019569
0.037182
0.074364
0.060665
0.064579
0.017613
0.009785
0.023483
0.007828
0.052838
0.02544
0.027397
0.029354
0.046967
0.041096
0.013699
0.019569
0.031311
1
10,181
C
A
C
T
G
C
T
C
C
T
G
C
T
C
C
C
G
C
A
G
G
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G
A
A
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C
T
C
C
C
A
C
A
G
C
T
G
T
0.023483
0.021526
0.029354
0.005871
0.033268
0.037182
0.009785
0.021526
0.037182
0.062622
0.046967
0.013699
0.015656
0.023483
0.015656
0.041096
0.074364
0.064579
0.07045
0.019569
0.009785
0.023483
0.009785
0.054795
0.02544
0.027397
0.027397
0.050881
0.04501
0.011742
0.015656
0.031311
1
10,182
T
C
C
C
G
T
C
G
T
C
C
A
C
C
A
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C
A
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A
C
C
T
A
C
A
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T
G
A
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G
A
A
A
A
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C
A
A
0.027397
0.021526
0.027397
0.033268
0.037182
0.02544
0.005871
0.043053
0.017613
0.041096
0.041096
0.033268
0.02544
0.037182
0.027397
0.041096
0.052838
0.052838
0.060665
0.019569
0.005871
0.003914
0.031311
0.027397
0.019569
0.027397
0.029354
0.050881
0.037182
0.021526
0.035225
0.039139
1
10,183
T
A
G
A
A
G
A
A
A
A
A
T
C
A
G
A
C
T
C
C
C
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C
C
G
C
C
T
T
G
C
T
G
C
C
C
A
C
C
T
G
T
0.074364
0.033268
0.039139
0.029354
0.037182
0.031311
0
0.039139
0.050881
0.021526
0.033268
0.037182
0.033268
0.017613
0.058708
0.039139
0.04501
0.046967
0.035225
0.011742
0.001957
0.009785
0.021526
0.039139
0.035225
0.023483
0.031311
0.023483
0.035225
0.011742
0.007828
0.04501
1
10,184
A
G
G
G
C
A
C
C
A
C
T
G
C
C
T
A
T
G
T
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C
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G
C
A
C
C
A
T
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A
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G
G
A
C
A
A
C
A
T
C
C
0.050881
0.02544
0.043053
0.037182
0.031311
0.027397
0.007828
0.035225
0.043053
0.023483
0.052838
0.02544
0.043053
0.033268
0.033268
0.035225
0.048924
0.048924
0.029354
0.001957
0
0.001957
0.019569
0.043053
0.039139
0.015656
0.029354
0.019569
0.056751
0.023483
0.033268
0.041096
1
10,185
C
A
G
A
A
A
T
C
G
C
T
G
C
T
G
G
T
G
C
T
C
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G
A
T
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G
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C
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G
C
T
G
A
A
G
T
A
0.043053
0.019569
0.035225
0.021526
0.052838
0.035225
0.009785
0.02544
0.04501
0.037182
0.037182
0.019569
0.02544
0.043053
0.029354
0.054795
0.058708
0.058708
0.033268
0.009785
0.003914
0.011742
0.013699
0.037182
0.033268
0.029354
0.031311
0.033268
0.035225
0.019569
0.013699
0.043053
1
10,186
G
G
C
A
T
G
T
G
C
C
C
G
A
G
T
A
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C
A
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C
T
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G
G
A
G
G
T
C
G
C
0.027397
0.02544
0.035225
0.039139
0.04501
0.023483
0.011742
0.037182
0.041096
0.041096
0.033268
0.027397
0.027397
0.035225
0.033268
0.041096
0.056751
0.043053
0.029354
0.013699
0.011742
0.001957
0.027397
0.033268
0.043053
0.029354
0.037182
0.02544
0.041096
0.021526
0.021526
0.039139
1
10,187
G
G
T
C
A
T
G
A
T
C
T
A
T
A
T
T
G
A
C
C
G
A
A
T
A
G
A
A
G
T
G
G
T
T
A
A
T
A
T
G
T
T
G
G
C
T
C
C
T
T
A
T
G
C
A
G
G
T
A
T
G
T
T
A
C
C
0.097847
0.035225
0.04501
0.050881
0.035225
0.023483
0
0.046967
0.056751
0.021526
0.023483
0.066536
0.023483
0.035225
0.02544
0.023483
0.033268
0.023483
0.017613
0.001957
0.003914
0.001957
0.041096
0.029354
0.046967
0.021526
0.015656
0.007828
0.017613
0.02544
0.058708
0.043053
1
10,188
A
C
G
T
A
G
T
A
A
T
G
A
A
A
G
G
C
A
A
C
A
T
G
A
T
A
T
G
A
T
A
G
C
C
T
G
G
T
C
C
A
C
T
G
G
G
G
C
T
A
G
T
T
A
G
T
A
A
A
G
C
T
C
C
T
A
0.074364
0.039139
0.04501
0.052838
0.037182
0.029354
0.007828
0.039139
0.029354
0.031311
0.037182
0.043053
0.029354
0.043053
0.035225
0.033268
0.033268
0.027397
0.015656
0
0
0
0.029354
0.027397
0.033268
0.009785
0.033268
0.013699
0.023483
0.031311
0.068493
0.046967
1
10,189
T
A
G
G
C
A
G
G
A
T
G
A
G
G
A
C
A
T
G
G
T
C
A
T
C
A
G
A
T
A
A
G
C
C
T
C
C
T
T
T
G
G
C
C
A
G
G
G
C
A
A
G
G
T
A
G
C
A
C
T
G
A
A
G
A
A
0.064579
0.015656
0.04501
0.048924
0.033268
0.035225
0.001957
0.029354
0.054795
0.031311
0.04501
0.039139
0.023483
0.031311
0.035225
0.031311
0.039139
0.035225
0.013699
0.005871
0.007828
0.007828
0.029354
0.046967
0.046967
0.017613
0.023483
0.023483
0.027397
0.035225
0.029354
0.04501
1
10,190
T
T
C
G
G
T
T
T
C
C
T
G
G
C
T
T
T
C
A
T
G
A
T
A
T
T
C
A
T
G
T
G
C
T
G
G
G
T
G
G
G
G
G
A
C
G
T
G
T
A
C
C
C
T
G
T
C
T
A
C
C
A
G
C
C
G
0.015656
0.009785
0.046967
0.019569
0.046967
0.033268
0.007828
0.035225
0.046967
0.037182
0.050881
0.027397
0.021526
0.037182
0.031311
0.04501
0.056751
0.050881
0.04501
0.005871
0.003914
0.001957
0.033268
0.031311
0.037182
0.031311
0.041096
0.033268
0.041096
0.037182
0.007828
0.029354
1