title large_stringlengths 0 979 | abstract large_stringlengths 1 94.7k | doi large_stringlengths 0 71 | pmid int64 21 38.1M | mesh_terms large_stringlengths 0 1.47k | journal large_stringlengths 1 239 | pubdate int16 1.97k 2.02k | chemical_list large_stringlengths 0 1.47k |
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Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells. | T helper 2 (Th2) cytokines interleukin (IL)-4 and IL-13, which activate signal transducer and activator of transcription 6 (STAT6) are expressed in the muscularis externa during nematode infection and are candidate mediators of the associated hypercontractility. To determine the locus of action of these cytokines, we e... | 10.1152/ajpgi.2002.282.2.G226 | 11,804,843 | D000818:Animals; D017252:CD3 Complex; D002217:Carbachol; D018679:Cholinergic Agonists; D004305:Dose-Response Relationship, Drug; D005769:Gastrointestinal Motility; D015870:Gene Expression; D018793:Interleukin-13; D015847:Interleukin-4; D007422:Intestines; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:... | American journal of physiology. Gastrointestinal and liver physiology | 2,002 | D017252:CD3 Complex; D018679:Cholinergic Agonists; D018793:Interleukin-13; D012333:RNA, Messenger; D019948:Receptors, Interleukin-4; D050800:STAT6 Transcription Factor; C494100:Stat6 protein, mouse; D015534:Trans-Activators; D015847:Interleukin-4; D002217:Carbachol |
Fatty acid transfer from Yarrowia lipolytica sterol carrier protein 2 to phospholipid membranes. | Sterol carrier protein 2 (SCP2) is an intracellular protein domain found in all forms of life. It was originally identified as a sterol transfer protein, but was recently shown to also bind phospholipids, fatty acids, and fatty-acyl-CoA with high affinity. Based on studies carried out in higher eukaryotes, it is believ... | 10.1016/j.bpj.2009.03.063 | 19,580,762 | D002352:Carrier Proteins; D002942:Circular Dichroism; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli; D005227:Fatty Acids; D031541:Fluorescence Resonance Energy Transfer; D010743:Phospholipids; D011485:Protein Binding; D017433:Protein Structure, Secondary; D011994:Recombinant Proteins; D012965:Sodi... | Biophysical journal | 2,009 | D002352:Carrier Proteins; D005227:Fatty Acids; D010743:Phospholipids; D011994:Recombinant Proteins; D053835:Unilamellar Liposomes; C072087:sterol carrier proteins; D014867:Water; D012965:Sodium Chloride |
Detection of significant pathways in osteoporosis based on graph clustering. | Osteoporosis is the most common and serious skeletal disorder among the elderly, characterized by a low bone mineral density (BMD). Low bone mass in the elderly is highly dependent on their peak bone mass (PBM) as young adults. Circulating monocytes serve as early progenitors of oste... | 10.3892/mmr.2012.1082 | 22,992,777 | D015519:Bone Density; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D006801:Humans; D009000:Monocytes; D020411:Oligonucleotide Array Sequence Analysis; D010024:Osteoporosis | Molecular medicine reports | 2,012 | |
[Does an Increase in Depressive Symptoms Lead to an Increase in Functional Impairment or vice versa? Results of the AgeCoDe and AgeQualiDe Study]. | OBJECTIVE
To clarify the link between depressive symptoms and functional impairment among the oldest old longitudinally.
METHODS
Longitudinal data (n = 1,272) were taken from a multicenter prospective cohort study ("Study on Needs, health service use, costs and health-related quality of life in a large sample of olde... | 10.1055/a-1089-3935 | 31,952,087 | D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression; D005858:Germany; D006801:Humans; D008137:Longitudinal Studies; D011446:Prospective Studies; D011788:Quality of Life | Psychiatrische Praxis | 2,020 | |
Evaluation of a DNA probe of plasmid origin for the detection of Chlamydia trachomatis in cultures and clinical specimens. | This study evaluates five cryptic plasmid-derived DNA probes in a 4-h slot-blot hybridization assay for the detection of Chlamydia trachomatis in cultures and clinical specimens. The probes, consisting of either the entire cloned 7.5 kbp cryptic plasmid pSE8 or one of four Hin dIII/Eco RI fragments measuring 710, 1055,... | 10.1016/s0890-8508(05)80013-1 | 1,779,980 | D001419:Bacteria; D015139:Blotting, Southern; D002478:Cells, Cultured; D002690:Chlamydia Infections; D002692:Chlamydia trachomatis; D003001:Cloning, Molecular; D015342:DNA Probes; D004269:DNA, Bacterial; D005069:Evaluation Studies as Topic; D005260:Female; D015723:Gene Library; D006801:Humans; D008297:Male; D010957:Pla... | Molecular and cellular probes | 1,991 | D015342:DNA Probes; D004269:DNA, Bacterial |
Coordinated control of quasilinear multiagent systems via output feedback predictive control. | This study considers the coordinated control for quasilinear multiagent systems (QMASs). An output feedback predictive control (OFPC) strategy is given to implement both coordination and simultaneous stability and output consensus (SSOC). In the OFPC strategy, a cost function aiming at coordination relationship is mini... | 10.1016/j.isatra.2021.10.004 | 34,689,961 | ISA transactions | 2,022 | ||
The effect of aging and inflammation on heat shock protein 27 in human monocytes and lymphocytes. | Heat shock proteins (Hsp) are highly conserved proteins and their synthesis is ubiquitous in virtually every species in which they have been sought. In the present study we have investigated the effect of age and inflammation on the induction of Hsp27 in human peripheral blood mononuclear cells, using flow cytometry. S... | 10.1016/j.exger.2006.01.006 | 16,504,445 | D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002478:Cells, Cultured; D003141:Communicable Diseases; D016207:Cytokines; D005260:Female; D005434:Flow Cytometry; D006360:Heat-Shock Proteins; D006801:Humans; D007249:Inflammation; D007963:Leukocytes, Mononuclear; D008214:Lymphocytes; D0082... | Experimental gerontology | 2,006 | D016207:Cytokines; D006360:Heat-Shock Proteins |
Cypress canker: a pandemic in progress. | Over the past 70 years a destructive blight of Cupressus macrocarpa and other Cupressaceae, caused by Seiridium cardinale, has spread worldwide from California, devastating forests, plantations, and ornamental cypresses. The epidemic has been particularly severe in the Mediterranean region, on C. sempervirens. A simila... | 10.1146/annurev.phyto.36.1.91 | 15,012,494 | Annual review of phytopathology | 1,998 | ||
The 6-MP versus placebo clinical trial in acute leukemia. | BACKGROUND
This article gives the status of clinical cancer research in the 1950's-1960's and tells the story of the development and conduct of the 6-mercaptopurine (6-MP) versus placebo clinical trial in acute leukemia through the initiation, design, conduct and analysis stages, with emphasis on the ethical aspects of... | 10.1177/1740774511407358 | 21,730,077 | D000964:Antimetabolites, Antineoplastic; D004311:Double-Blind Method; D006801:Humans; D015122:Mercaptopurine; D017063:Outcome Assessment, Health Care; D010919:Placebos; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D016016:Proportional Hazards Models; D012074:Remission Induction | Clinical trials (London, England) | 2,011 | D000964:Antimetabolites, Antineoplastic; D010919:Placebos; D015122:Mercaptopurine |
[Technics for isolation, incubation and preliminary identification tests]. | In this report the AA. emphasize the fact that anaerobes are mostly isolated from mixed cultures in which several bacteria are present. Therefore they suggest to grow all the bacteria under the best conditions and consequently to select the anaerobes from the aerobes. Furthermore they describe the selecting techniques ... | 399,835 | D000191:Actinomycetaceae; D000693:Anaerobiosis; D001419:Bacteria; D001431:Bacteriological Techniques; D001438:Bacteroidaceae; D003013:Clostridium; D003470:Culture Media; D006801:Humans; D010462:Peptostreptococcus; D011424:Propionibacterium | Annali dell'Istituto superiore di sanita | 1,979 | D003470:Culture Media | |
Recombinant Human Erythropoietin (RHuEpo) and Granular Colony Stimulating Factor (G-CSF) in hepatitis C virus (HCV) related to mixed cryoglobulinaemia associated to membranoproliferative glomerulonephritis type I: a case report description. | HCV infection is related to hepatic disease and mixed cryoglobulinaemia (MC). Renal involvement is reported in one third of cryoglobulinaemic patients. The combination of HCV related MC with renal involvement has been associated with poor survival and identified as Hepatitis C Virus Risk Syndrome (HCV RS). Here we desc... | 25,551,853 | D000740:Anemia; D000998:Antiviral Agents; D003449:Cryoglobulinemia; D004359:Drug Therapy, Combination; D004921:Erythropoietin; D015432:Glomerulonephritis, Membranoproliferative; D016179:Granulocyte Colony-Stimulating Factor; D006526:Hepatitis C; D006801:Humans; D007372:Interferons; D008103:Liver Cirrhosis; D008297:Male... | Le infezioni in medicina | 2,014 | D000998:Antiviral Agents; D011994:Recombinant Proteins; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor; D012254:Ribavirin; D007372:Interferons | |
Direct embryotoxicity of cocaine in rats: effects on mitochondrial activity, cardiac function, and growth and development in vitro. | Day 10 rat embryos were exposed to cocaine HCl (10-100 microM) in vitro in 20% (designated normoxic) and 10-12% (designated moderately hypoxic) oxygen and examined the following day. In normoxia, it caused prompt and significant decreases in heart rates and significant reductions in measures of growth and development a... | 10.1002/tera.1420420106 | 2,392,777 | D000818:Animals; D003042:Cocaine; D004579:Electron Transport; D005314:Embryonic and Fetal Development; D005260:Female; D005947:Glucose; D006339:Heart Rate; D000860:Hypoxia; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange; D008929:Mitochondria, Heart; D009247:NADH, NADPH Oxidoreductases; D011247:Pregnancy; ... | Teratology | 1,990 | D009247:NADH, NADPH Oxidoreductases; D003042:Cocaine; D005947:Glucose |
Urinary cadmium and beta 2-microglobulin: correlation with nutrition and smoking history. | Urinary cadmium and beta 2-microglobulin concentrations from approximately 1000 samples from the general adult U.S. population, collected as part of the National Health and Nutritional Examination Survey II (NHANES II), were related to nutritional and smoking history of the individuals. Urinary cadmium concentration wa... | 10.1080/15287398809531199 | 3,050,141 | D002104:Cadmium; D002136:Calcium, Dietary; D003300:Copper; D004032:Diet; D006801:Humans; D007501:Iron; D009749:Nutrition Surveys; D009752:Nutritional Status; D012907:Smoking; D001613:beta 2-Microglobulin | Journal of toxicology and environmental health | 1,988 | D002136:Calcium, Dietary; D001613:beta 2-Microglobulin; D002104:Cadmium; D003300:Copper; D007501:Iron |
Ultrasound in the interstitial pulmonary fibrosis. Can it facilitate a best routine assessment in rheumatic disorders? | Ultrasound (US) is increasing its potential in the assessment of several rheumatic disorders. Recently, different applications of this imaging technique have emerged. Interesting data supporting its utility and validity in the assessment of the lung to detect and quantify interstitial pulmonary fibrosis in rheumatic di... | 10.1007/s10067-016-3329-3 | 27,325,229 | D006801:Humans; D008168:Lung; D017563:Lung Diseases, Interstitial; D011658:Pulmonary Fibrosis; D012216:Rheumatic Diseases; D063189:Symptom Assessment; D014463:Ultrasonography | Clinical rheumatology | 2,016 | |
Promoting the Sustainable Recovery of Hospitality in the Post-Pandemic Era: A Comparative Study to Optimize the Servicescapes. | As COVID-19 spread throughout the world, the hospitality and tourism sectors were hard hit as no other industry. For this reason, the UNWTO developed the One Planet Vision as a response to a sustainable recovery of the tourism sector. At present, when people are starting to travel and stay at hotels again, it is import... | 10.3390/ijerph20021100 | 36,673,855 | D006801:Humans; D000086382:COVID-19; D036262:Empirical Research; D007221:Industry; D058873:Pandemics | International journal of environmental research and public health | 2,023 | |
Event Probabilities Have a Different Impact on Early and Late Electroencephalographic Measures Regarded as Metrics of Prediction. | The oddball protocol has been used to study the neural and perceptual consequences of implicit predictions in the human brain. The protocol involves presenting a sequence of identical repeated events that are eventually broken by a novel "oddball" presentation. Oddball presentations have been linked to increased neural... | 10.1162/jocn_a_02076 | 37,902,587 | D006801:Humans; D000161:Acoustic Stimulation; D004569:Electroencephalography; D005071:Evoked Potentials; D011336:Probability; D001921:Brain | Journal of cognitive neuroscience | 2,024 | |
Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly. | The N-terminal domain (NTD) of alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) and kainate glutamate receptors plays an important role in controlling subtype specific receptor assembly. To identify NTD subdomains involved in this process we generated AMPA glutamate receptor 3 (GluR3) mutants having intra-NTD s... | 10.1074/jbc.M408413200 | 15,703,162 | D000409:Alanine; D000595:Amino Acid Sequence; D000818:Animals; D015153:Blotting, Western; D002462:Cell Membrane; D003545:Cysteine; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D017353:Gene Deletion; D047468:Immunoprecipitation; D051379:Mice; D008958:Models, Molecular; D0089... | The Journal of biological chemistry | 2,005 | D018075:RNA, Complementary; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D018092:Receptors, Kainic Acid; C104723:glutamate receptor ionotropic, AMPA 3; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D003545:Cysteine; D000409:Alanine |
HIV infection and the pancreas: risk factors and potential management guidelines. | One thousand and eighty-one evaluable HIV-infected patients were assessed for pancreatic abnormalities in a prospective case-control study including the whole follow-up period of each patient (minimum 12 months). The 435 patients (40.2%), who experienced at least one episode of confirmed pancreatic laboratory abnormali... | 10.1258/ijsa.2007.007076 | 18,334,062 | D000328:Adult; D000681:Amylases; D000900:Anti-Bacterial Agents; D044966:Anti-Retroviral Agents; D000995:Antitubercular Agents; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections; D006801:Humans; D007517:Isoamylase; D008049:Lipase; D008297:Male; D010179:Pancreas; D010182:Pancreatic Diseases; D017410:Pr... | International journal of STD & AIDS | 2,008 | D000900:Anti-Bacterial Agents; D044966:Anti-Retroviral Agents; D000995:Antitubercular Agents; D008049:Lipase; D000681:Amylases; D007517:Isoamylase |
Outcome of total hip replacement in rheumatic arthritis. | Background. Degenerative changes caused by rheumatoid arthritis (RA) typically occur in the hands and feet, but are not rare in the hip. The purpose of our research was to assess outcome in RA patients undergoing total hip arthroplasty. Material and methods. From 1992 to 2000 we performed total arthroplasty in 166 RA p... | 17,611,427 | Ortopedia, traumatologia, rehabilitacja | 2,005 | |||
Taking Stock of Retinal Gene Therapy: Looking Back and Moving Forward. | Over the past 20 years, there has been tremendous progress in retinal gene therapy. The safety and efficacy results in one early-onset severe blinding disease may lead to the first gene therapy drug approval in the United States. Here, we review how far the field has come over the past two decades and speculate on the ... | 10.1016/j.ymthe.2017.03.008 | 28,391,961 | D000260:Adenoviruses, Human; D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D017277:Drug Approval; D005136:Eye Proteins; D015870:Gene Expression; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D056965:Injections, Intraocular; D009154:Mutation; D012160:Retina; D0121... | Molecular therapy : the journal of the American Society of Gene Therapy | 2,017 | D005136:Eye Proteins |
The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China. | Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC). Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respec... | 10.7150/jca.22085 | 29,675,100 | Journal of Cancer | 2,018 | ||
Comparison of Powerlifting Performance in Trained Men Using Traditional and Flexible Daily Undulating Periodization. | Colquhoun, RJ, Gai, CM, Walters, J, Brannon, AR, Kilpatrick, MW, D'Agostino, DP, and Campbell, WI. Comparison of powerlifting performance in trained men using traditional and flexible daily undulating periodization. J Strength Cond Res 31(2): 283-291, 2017-Daily undulating periodization (DUP) is a growing trend, both i... | 10.1519/JSC.0000000000001500 | 28,129,275 | D000328:Adult; D001823:Body Composition; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D005082:Physical Exertion; D055070:Resistance Training; D055815:Young Adult | Journal of strength and conditioning research | 2,017 | |
Association of genetic polymorphisms of SelS with Type 2 diabetes in a Chinese population. | Background: Selenoprotein S (SelS) gene expression is positively correlated to triglyceride (TG) concentrations and is associated with diabetes in animal model. However, the relationship between genetic polymorphisms of SelS and Type 2 diabetes (T2DM) remains unclear. Methods: In the present study, we genotyped four si... | 10.1042/BSR20181696 | 30,413,610 | D000328:Adult; D000483:Alleles; D002681:China; D003924:Diabetes Mellitus, Type 2; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D0511... | Bioscience reports | 2,018 | D008565:Membrane Proteins; C487710:SELENOS protein, human; D051140:Selenoproteins; D014280:Triglycerides |
Phonological codes are assembled before word fixation: evidence from boundary paradigm in sentence reading. | This experiment employed the boundary paradigm during sentence reading to explore the nature of early phonological coding in reading. Fixation durations were shorter when the parafoveal preview was the correct word than when it was a spelling control pseudoword. In contrast, there was no significant difference between ... | 10.1016/S0093-934X(03)00442-5 | 15,172,547 | D005403:Fixation, Ocular; D005584:Fovea Centralis; D006801:Humans; D010700:Phonetics; D011930:Reaction Time; D011932:Reading; D012438:Saccades | Brain and language | 2,004 | |
Gender Differences in Machine Learning Models of Trauma and Suicidal Ideation in Veterans of the Iraq and Afghanistan Wars. | Suicide rates among recent veterans have led to interest in risk identification. Evidence of gender-and trauma-specific predictors of suicidal ideation necessitates the use of advanced computational methods capable of elucidating these important and complex associations. In this study, we used machine learning to exami... | 10.1002/jts.22210 | 28,741,810 | D000328:Adult; D055826:Afghan Campaign 2001-; D019540:Area Under Curve; D003863:Depression; D005260:Female; D006801:Humans; D054542:Iraq War, 2003-2011; D000069550:Machine Learning; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D012372:ROC Curve; D018570:Risk Assessment; D012307:Risk Factors; D01273... | Journal of traumatic stress | 2,017 | |
Correlated evolution of diaspore traits and potential frugivore-mediated selection in a fleshy-fruited tropical lineage (Artabotrys, Annonaceae). | Dispersal syndromes are often defined by reference to fruit traits that are associated with distinct frugivore guilds. Studies rarely examine the relationship between seed traits and frugivores or test the alternative hypothesis that traits are shaped by climatic variables. We assess whether the evolution of seed size ... | 10.1111/evo.14046 | 32,562,267 | D029061:Annonaceae; D005075:Biological Evolution; D020387:Food Chain; D005638:Fruit; D012639:Seeds; D012641:Selection, Genetic | Evolution; international journal of organic evolution | 2,020 | |
Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models. | How particular bone marrow niche factors contribute to the leukemogenic activities of leukemia-initiating cells (LICs) remains largely unknown. Here, we showed that ATP levels were markedly increased in the bone marrow niches of mice with acute myeloid leukemia (AML), and LICs preferentially localized to the endosteal ... | 33,301,426 | D000255:Adenosine Triphosphate; D000818:Animals; D001853:Bone Marrow; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins; D009374:Neoplasms, Experimental; D014411:Neoplastic Stem Cells; D058486:Receptors, Purinergic P2X7; D015398:Signal Transduction; D05901... | The Journal of clinical investigation | 2,021 | D009363:Neoplasm Proteins; C546468:P2RX7 protein, human; C546469:P2rx7 protein, mouse; D058486:Receptors, Purinergic P2X7; D000255:Adenosine Triphosphate | |
Factors associated with wasting and stunting among children aged 06-59 months in South Ari District, Southern Ethiopia: a community-based cross-sectional study. | BACKGROUND
Child undernutrition is a major public health problem in Ethiopia despite different nutrition-specific and sensitive interventions implemented by the government. However, evidence regarding the burden and responsible factors is limited in the South Ari district. Hence, this study aimed to assess factors asso... | 10.1186/s40795-023-00683-3 | 36,829,183 | BMC nutrition | 2,023 | ||
Leishmania infantum-Derived Glycoinositolphospholipids in the Immunodiagnosis of Subclinically Infected Dogs. | Lipophosphoglycan (LPG), when used as an ELISA target, confers high specificity and sensitivity to the detection of Leishmania infantum antibodies in dogs. Glycoconjugates are economically viable because the yield is very high after extraction/purification. In addition, they are very stable, which allows their use in p... | 10.3389/fvets.2021.581148 | 33,778,030 | Frontiers in veterinary science | 2,021 | ||
Urinary incontinence prevalence and factors associated with patients talking with doctors about urine control. | Objectives
Patient perceptions of their doctors may influence talking to them about urinary incontinence (UI). We estimated prevalence of UI among Medicare beneficiaries and assessed association between beneficiaries' demographic and clinical characteristics and whether they spoke to their doctor about UI and associati... | 10.4103/jfmpc.jfmpc_1955_22 | 37,767,451 | Journal of family medicine and primary care | 2,023 | ||
DEAE-Dextran Transfection. | Biochemical methods of transfection, including calcium phosphate-mediated and diethylaminoethyl (DEAE)-dextran-mediated transfection, have been used for many years to deliver nucleic acids into cultured eukaryotic cells. Here, we briefly review the use of DEAE-dextran in transfection. | 10.1101/pdb.top096263 | 29,967,279 | D003637:DEAE-Dextran; D014162:Transfection | Cold Spring Harbor protocols | 2,018 | D003637:DEAE-Dextran |
Vitamin C Deficiency and Oxidant Levels in Children With Transfusion-Dependent b-Thalassemia. | OBJECTIVES
To study vitamin C levels in children with transfusion-dependent b-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in deficient patients.
METHODS
This case-control study enrolled 100 chil... | 33,772,531 | D001206:Ascorbic Acid Deficiency; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D016877:Oxidants; D013789:Thalassemia; D017086:beta-Thalassemia | Indian pediatrics | 2,021 | D016877:Oxidants | |
Evaluation of the hearing loss associated with cis-platinum treatment by high-frequency audiometry. | The effect of cis-platinum treatment on the hearing of 23 ovarian cancer patients was evaluated using standard and high-frequency audiometry. Twenty-two percent of the patients developed a hearing loss of at least 15 db, 13% in the range 125-8000 Hz and 9% only in the high-frequency area above 8 kHz. However, due to th... | 10.1016/0090-8258(89)90519-2 | 2,722,056 | D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D001299:Audiometry; D002945:Cisplatin; D003520:Cyclophosphamide; D004317:Doxorubicin; D005260:Female; D034381:Hearing Loss; D006316:Hearing Loss, High-Frequency; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms | Gynecologic oncology | 1,989 | D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin |
Severe thrombocytopenia due to combined cimetidine and phenytoin therapy. | Combined use of cimetidine and phenytoin among 1512 neurosurgical patients has led to severe thrombocytopenia in 4 patients. One died, and 1 became vegetative. We propose that cimetidine and phenytoin act synergistically to depress the megakaryocyte at the bone marrow. Because thrombocytopenia and inadequate hemostasis... | 10.1227/00006123-198706000-00025 | 3,614,578 | D000328:Adult; D000368:Aged; D001855:Bone Marrow Diseases; D002927:Cimetidine; D006801:Humans; D008297:Male; D010672:Phenytoin; D013921:Thrombocytopenia | Neurosurgery | 1,987 | D010672:Phenytoin; D002927:Cimetidine |
Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells. | The use of lentiviral vectors for gene transfer into hematopoietic stem cells has raised considerable interest as these vectors can permanently integrate their genome into quiescent cells. Vectors based on alternative lentiviruses would theoretically be safer than HIV-1-based vectors and could also be used in HIV-posit... | 10.1016/j.ymthe.2005.01.022 | 16,099,415 | D000818:Animals; D018952:Antigens, CD34; D002460:Cell Line; D005434:Flow Cytometry; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D049452:Green Fluorescent Proteins; D006678:HIV; D006412:Hematopoietic Stem Cells; D006801:Humans; D066298:In Vitro Techniques; D004860:Infectious Anemi... | Molecular therapy : the journal of the American Society of Gene Therapy | 2,005 | D018952:Antigens, CD34; D049452:Green Fluorescent Proteins; D012313:RNA; D017493:Leukocyte Common Antigens |
Time relationships and reversal by two indoleamines of the pinealectomy-inhibited thyrotropin secretion in male rats. | Time relationships and mediators of the inhibitory effect of pinealectomy on cold-induced TSH secretion were studied in male Sprague-Dawley rats. Pinealectomy but not sham operation significantly reduced the TSH cold-response (30 min at +4 degrees C) in 6-8 week-old rats on the 3rd postoperative day. Longer postoperati... | 3,450,985 | D000818:Animals; D002243:Carbolines; D003080:Cold Temperature; D008297:Male; D008550:Melatonin; D010870:Pineal Gland; D051381:Rats; D012636:Secretory Rate; D012701:Serotonin; D013972:Thyrotropin; D014668:Vasotocin | Medical biology | 1,987 | D002243:Carbolines; C002272:6-methoxytryptoline; D012701:Serotonin; D013972:Thyrotropin; D008550:Melatonin; D014668:Vasotocin | |
European isolation and confinement study. Ethological analysis of spatial behavior. | The purpose of this study was to evaluate through an ethological approach the behavioral consequences of confinement and isolation in the restricted space of a hyperbaric chamber at low pressure on six subjects for a period of 28 days. The quantitative analysis consisted in tracing the use of space, minute by minute (i... | 8,124,512 | D006126:Group Processes; D006801:Humans; D009043:Motor Activity; D012934:Social Isolation; D013026:Space Flight | Advances in space biology and medicine | 1,993 | ||
Contextual influences on polydrug use among young, low-income women: effects of neighborhood and personal networks. | This study assessed contextual risks for polydrug use in a triethnic sample (non-Hispanic white, African American, Hispanic) of young women with a low income. For the current analysis, a total of 712 young women aged 18 to 31 years who sought care in state-funded family planning clinics in southeast Texas from December... | 10.1080/10550490701863025 | 18,393,057 | D000293:Adolescent; D000328:Adult; D044383:Black People; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006630:Hispanic or Latino; D006801:Humans; D013287:Illicit Drugs; D016015:Logistic Models; D015999:Multivariate Analysis; D011203:Poverty; D012111:Residence Characteristics; D012307:Risk Fa... | The American journal on addictions | 2,008 | D013287:Illicit Drugs |
The desmoglein-specific cytoplasmic region is intrinsically disordered in solution and interacts with multiple desmosomal protein partners. | The desmoglein-specific cytoplasmic region (DSCR) is a conserved region of unknown structure and function that uniquely defines the desmoglein family of cell adhesion molecules. It is the site of caspase cleavage during apoptosis, and its mutation is linked to cardiomyopathy. Here, we reveal that a 276-residue DSCR con... | 10.1016/j.jmb.2008.12.054 | 19,136,012 | D000595:Amino Acid Sequence; D002942:Circular Dichroism; D051187:Desmocollins; D051183:Desmoglein 1; D051180:Desmoplakins; D006801:Humans; D008969:Molecular Sequence Data; D051191:Plakophilins; D011485:Protein Binding; D017433:Protein Structure, Secondary; D016415:Sequence Alignment; D051185:gamma Catenin | Journal of molecular biology | 2,009 | C081560:DSC1 protein, human; C495297:DSG1 protein, human; D051187:Desmocollins; D051183:Desmoglein 1; D051180:Desmoplakins; C495292:JUP protein, human; C495335:PKP1 protein, human; D051191:Plakophilins; D051185:gamma Catenin |
Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain. | Increased glutamate availability in the spinal cord and primary afferent nerves plays an important role in acute and chronic pain. Afferent ectopic discharges from the site of nerve injury constitute a source of abnormal sensory input to the spinal dorsal horn. The ectopic afferent activity is largely responsible for t... | 10.1124/jpet.300.2.662 | 11,805,230 | D000818:Animals; D001522:Behavior, Animal; D002268:Carboxypeptidases; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D004791:Enzyme Inhibitors; D043425:Glutamate Carboxypeptidase II; D018698:Glutamic Acid; D007275:Injections, Intravenous; D008297:Male; D009475:Neurons, Afferent; D018696:Neuroprote... | The Journal of pharmacology and experimental therapeutics | 2,002 | C402107:2-(phosphonomethyl)pentanedioic acid; D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D009943:Organophosphorus Compounds; D018698:Glutamic Acid; D002268:Carboxypeptidases; D043425:Glutamate Carboxypeptidase II |
Redescription of Dinemoura discrepans Cressey, 1967 (Copepoda: Pandaridae) parasitic on four species of sharks off southeast coast of Taiwan. | Dinemoura discrepans Cressey, 1967 (Copepoda, Siphonostomatoida, Pandaridae) is redescribed based on the specimens taken from four species of sharks caught off the southeast coast of Taiwan. The four species of sharks are: pelagic thresher, Alopias pelagicus Nakamura; bigeye thresher, A. superciliosus Lowe; blacktip sh... | 10.14411/fp.2011.031 | 22,263,312 | D000818:Animals; D033342:Copepoda; D004478:Ectoparasitic Infestations; D005260:Female; D005393:Fish Diseases; D058507:Host Specificity; D008297:Male; D012754:Sharks; D013045:Species Specificity; D013624:Taiwan | Folia parasitologica | 2,011 | |
Synthesis of N,N-Dialkylamino-nor-Dihydroxanthene-Hemicyanine Fused Near-Infrared Fluorophores and Their First Water-Soluble and/or Bioconjugatable Analogues. | The effective synthesis of extended conjugated N,N-dialkylamino-nor-dihydroxanthene-based fluorophores is described from diversely functionalized salicylic aldehydes. The access to these original fluorescent derivatives proceeded in two steps through a one-pot construction of the unusual nor-dihydroxanthene (nor-DHX) s... | 10.1002/asia.201700176 | 28,225,218 | D002232:Carbocyanines; D005456:Fluorescent Dyes; D007259:Infrared Rays; D012710:Serum Albumin, Bovine; D012995:Solubility; D014867:Water; D014966:Xanthenes | Chemistry, an Asian journal | 2,017 | D002232:Carbocyanines; D005456:Fluorescent Dyes; D014966:Xanthenes; C000601156:tetramethylene hemicyanine; D014867:Water; D012710:Serum Albumin, Bovine |
Roles of N-acetylglutaminylglutamine amide and glycine betaine in adaptation of Pseudomonas aeruginosa to osmotic stress. | The mechanism of osmotic stress adaptation in Pseudomonas aeruginosa PAO1 was investigated. By using natural abundance 13C nuclear magnetic resonance spectroscopy, osmotically stressed cultures were found to accumulate glutamate, trehalose, and N-acetylglutaminylglutamine amide, an unusual dipeptide previously reported... | 10.1128/aem.59.2.473-478.1993 | 8,434,912 | D001622:Betaine; D004151:Dipeptides; D005971:Glutamates; D011550:Pseudomonas aeruginosa; D012965:Sodium Chloride; D014199:Trehalose; D014882:Water-Electrolyte Balance | Applied and environmental microbiology | 1,993 | D004151:Dipeptides; D005971:Glutamates; C060785:N-acetylglutaminylglutamine amide; D001622:Betaine; D012965:Sodium Chloride; D014199:Trehalose |
Thrombotic microangiopathy on kidney biopsy in a patient with TAFRO syndrome. | TAFRO syndrome represents a characteristic constellation of symptoms comprising Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, and Organomegaly, and is considered to be a clinicopathologic variant of idiopathic multicentric Castleman disease. A 51-year-old woman was admitted to the hospital complaining o... | 10.1007/s13730-018-0338-x | 29,766,467 | D005871:Castleman Disease; D004487:Edema; D005260:Female; D005920:Glomerular Mesangium; D005938:Glucocorticoids; D006801:Humans; D007668:Kidney; D007674:Kidney Diseases; D007678:Kidney Glomerulus; D008775:Methylprednisolone; D008875:Middle Aged; D012598:Sclerosis; D013577:Syndrome; D057049:Thrombotic Microangiopathies;... | CEN case reports | 2,018 | D005938:Glucocorticoids; D008775:Methylprednisolone |
Management of acute HVE infection in a patient treated with rituximab for rheumatoid arthritis. | INTRODUCTION
Acute E hepatitis becomes more frequent in immunocompromised patients. No guidelines are available to date for the management of this infection and of the immunosuppressive treatment.
METHODS
We report a case of acute E hepatitis treated with ribavirine in a patient known for rheumatoid arthritis and tre... | 27,055,728 | D000208:Acute Disease; D018501:Antirheumatic Agents; D000998:Antiviral Agents; D001172:Arthritis, Rheumatoid; D005260:Female; D016751:Hepatitis E; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D012254:Ribavirin; D000069283:Rituximab | Joint bone spine | 2,016 | D018501:Antirheumatic Agents; D000998:Antiviral Agents; D012254:Ribavirin; D000069283:Rituximab | |
Early displacement of two part proximal humerus fractures treated with intramedullary proximal humeral nail. | INTRODUCTION
Proximal humerus nails (PHN) are commonly used for the treatment of simple proximal humerus fractures, and have a reported malunion rate of about 10%. The surgeons who used PHN in one medical institution have noticed a high rate of fracture re-displacement in the early post-operative period. This study's a... | 10.1016/j.jor.2019.11.027 | 32,021,038 | Journal of orthopaedics | 2,020 | ||
Outcome of simultaneous angioembolization and nephron sparing surgery in large renal angiomyolipomas. | AIM
To study the outcome of simultaneous angioembolization and nephron sparing surgery in large renal angiomyolipomas.
MATERIALS AND METHODS
A prospective study of carried out from 2016 to 2019. A total of 15 patients were included in the study with a lesion (angiomyolipoma) more than 10 cm in size, suitable for neph... | 10.1177/03915603211036428 | 34,346,257 | D000328:Adult; D018207:Angiomyolipoma; D002292:Carcinoma, Renal Cell; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms; D008297:Male; D000072662:Margins of Excision; D009392:Nephrectomy; D009399:Nephrons; D011446:Prospective Studies; D012189:Retrospective Studies | Urologia | 2,022 | |
The relationship between early childhood development and feeding practices during the dietary transitional period in rural China: a cross-sectional study. | Introduction
Early childhood feeding environments and practices not only affect children's nutritional status but also provide children with a variety of external stimulations to affect the development of the child's brain, especially for the first 1,000 days of children. The relationship between early childhood develo... | 10.3389/fpubh.2023.1202712 | 37,637,814 | D002648:Child; D005260:Female; D006801:Humans; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004032:Diet; D001942:Breast Feeding; D009752:Nutritional Status; D002681:China | Frontiers in public health | 2,023 | |
Multifunctional Self-Assembly with NIR Light-Activated Cascade Effect for Improving Local Treatment on Solid Tumors. | Incomplete local treatment of solid tumors is the main cause of tumor difficult to cure, and easily leads to tumor metastasis and recurrence. The dense external matrix and hypoxic microenvironment of solid tumors severely restrict the therapy efficacy of local tumors. Enhancing the infiltration ability of agents to tum... | 10.1021/acsami.2c00448 | 35,297,244 | D045744:Cell Line, Tumor; D006801:Humans; D000860:Hypoxia; D007259:Infrared Rays; D053758:Nanoparticles; D009369:Neoplasms; D010778:Photochemotherapy; D059016:Tumor Microenvironment | ACS applied materials & interfaces | 2,022 | |
Tuberculous arthritis: a case study and review of the literature. | Tuberculosis of the bones and joints is a rare but treatable disease. This curable condition is frequently overlooked in the differential diagnosis, and often serious cases are not diagnosed until after severe joint destruction has already taken place. The literature on tuberculosis of the bones and joints is reviewed ... | 3,973,347 | D000328:Adult; D001168:Arthritis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011859:Radiography; D014373:Tuberculin; D014394:Tuberculosis, Osteoarticular | The Journal of foot surgery | 1,985 | D014373:Tuberculin | |
[Sebaceous carcinoma of the parotid gland]. | Sebaceous carcinoma is a rare tumor, from the adnexal epithélium of the sebaceous glands. Usually, lesions arise in meibonian glands of the eyelid. However, extraocular lesions within head and neck have been reported. We report a case of recurrent sebaceous carcinoma of the parotid gland without metastases. | 10,769,569 | D000328:Adult; D002277:Carcinoma; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010307:Parotid Neoplasms; D012626:Sebaceous Gland Neoplasms | Revue de laryngologie - otologie - rhinologie | 1,999 | ||
Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins. | Multiple intracellular receptors of the FK506 binding protein (FKBP) family of peptidylprolyl cis/trans-isomerases are potential targets for the immunosuppressive drug FK506. Inhibition of the protein phosphatase calcineurin (CaN), which has been implicated in the FK506-mediated blockade of T cell proliferation, was sh... | 10.1021/bi061616p | 17,176,100 | D000595:Amino Acid Sequence; D000818:Animals; D019703:Calcineurin; D065095:Calcineurin Inhibitors; D002147:Calmodulin; D002417:Cattle; D004791:Enzyme Inhibitors; D006801:Humans; D007166:Immunosuppressive Agents; D019169:Jurkat Cells; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes; D011485:Protein Bindin... | Biochemistry | 2,006 | D065095:Calcineurin Inhibitors; D002147:Calmodulin; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D009097:Multienzyme Complexes; D019703:Calcineurin; D022061:Tacrolimus Binding Protein 1A; D022021:Tacrolimus Binding Proteins; C403484:tacrolimus binding protein 1B; C403486:tacrolimus binding protein 5; D0... |
Plasma membrane Ca-ATPase isoform expression in human cataractous lenses compared to age-matched clear lenses. | The plasma membrane calcium ATPase (PMCA) pump is the major mechanism by which calcium is removed from the lens. The aim of this study was to determine if mRNA and proteins levels of PMCA isoforms changed with age or lens opacity. mRNA was quantified using a quantitative real-time reverse transcription polymerase chain... | 10.1159/000113886 | 18,223,301 | D000328:Adult; D000368:Aged; D000375:Aging; D015153:Blotting, Western; D002386:Cataract; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007908:Lens, Crystalline; D008297:Male; D053499:Plasma Membrane Calcium-Transporting ATPases; D012333:RNA, Messenger; D020133:Reverse Transcriptase Polymerase Chain Reaction | Ophthalmic research | 2,008 | D007527:Isoenzymes; D012333:RNA, Messenger; D053499:Plasma Membrane Calcium-Transporting ATPases |
[Evaluations of extreme myopia correction with phakic posterior chamber intraocular lens and laser in situ keratomileusis]. | PURPOSE
To compare and evaluate the efficacy, safety and stability of extreme myopia correction with Phakic Posterior Chamber Intraocular Lens (PPCIOL) Keratomileusis (Lasik). and Laser in situ
METHODS
This prospective study enrolled 43 cases of extreme myopia. The PPCIOL group was inserted Implantable Contact Lens (... | 15,656,359 | D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D054018:Lasers, Excimer; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D009216:Myopia; D018903:Photorefractive Keratectomy; D011446:Prospective Studies; D012029:Refraction, Ocular; D016896:Treatment Outcome; D014792:Visual A... | Yan ke xue bao = Eye science | 2,004 | ||
WE-G-BRCD-08: Virtual Couch Shift (VCS) by Online Plan Re-Optimization for the MRI Linear Accelerator. | PURPOSE
With the MRI accelerator it will be possible to get continuous patient anatomy updates, ranging from organ deformation to patient translation. To compensate for translations, one can re-optimize the treatment plan based on the online MRI images. Consequently, the IMRT optimization system should be fast and robu... | 10.1118/1.4736185 | 28,519,627 | Medical physics | 2,012 | ||
Effect of sequence on the ionization behavior of a series of amphiphilic polypeptides. | The behavior of five polypeptides made of hydrophilic and pH-responsive aspartic acid (Asp) and hydrophobic phenylalanine (Phe), which had been prepared by stitching together short well-defined sequences of Asp and Phe, was studied as a function of pH. The effect of pH on these polypeptides referred to as (Asp3Phe1)n, ... | 10.1021/la400030j | 23,484,851 | D000595:Amino Acid Sequence; D057927:Hydrophobic and Hydrophilic Interactions; D010455:Peptides; D011721:Pyrenes; D013501:Surface-Active Agents; D014867:Water | Langmuir : the ACS journal of surfaces and colloids | 2,013 | D010455:Peptides; D011721:Pyrenes; D013501:Surface-Active Agents; D014867:Water; C030984:pyrene |
Pyridoxine Deficiency Exacerbates Neuronal Damage after Ischemia by Increasing Oxidative Stress and Reduces Proliferating Cells and Neuroblasts in the Gerbil Hippocampus. | We investigated the effects of pyridoxine deficiency on ischemic neuronal death in the hippocampus of gerbil (n = 5 per group). Serum pyridoxal 5'-phosphate levels were significantly decreased in Pyridoxine-deficient diet (PDD)-fed gerbils, while homocysteine levels were significantly increased in sham- and ischemia-op... | 10.3390/ijms21155551 | 32,759,679 | D000818:Animals; D002545:Brain Ischemia; D019208:Brain-Derived Neurotrophic Factor; D049109:Cell Proliferation; D004032:Diet; D005849:Gerbillinae; D006624:Hippocampus; D051267:NF-E2-Related Factor 2; D058953:Neural Stem Cells; D009474:Neurons; D018384:Oxidative Stress; D011736:Pyridoxine | International journal of molecular sciences | 2,020 | D019208:Brain-Derived Neurotrophic Factor; D051267:NF-E2-Related Factor 2; D011736:Pyridoxine |
A stable phage lysin (Cpl-1) dimer with increased antipneumococcal activity and decreased plasma clearance. | Bacteriophages (phages) produce endolysins (lysins) as part of their lytic cycle in order to degrade the peptidoglycan layer of the infected bacteria for subsequent release of phage progeny. Because these enzymes maintain their lytic and lethal activity against Gram-positive bacteria when added extrinsically to the cel... | 10.1016/j.ijantimicag.2011.08.009 | 21,982,146 | D000595:Amino Acid Sequence; D000818:Animals; D001435:Bacteriophages; D019281:Dimerization; D010450:Endopeptidases; D006207:Half-Life; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D010457:Peptidoglycan; D... | International journal of antimicrobial agents | 2,011 | D010457:Peptidoglycan; D010450:Endopeptidases; C001143:endolysin |
Effectiveness of specialized rehabilitation after mild traumatic brain injury: A systematic review and meta-analysis. | OBJECTIVE
To determine the effectiveness of specialized rehabilitation in adults with prolonged symptoms, or risk of prolonged symptoms, following mild traumatic brain injury.
DATA SOURCES
Randomized controlled trials or non-randomized controlled studies published between 1 Jan 2000 and 10 Mar 2019 in Cochrane Contro... | 10.2340/16501977-2791 | 33,492,404 | D000293:Adolescent; D000328:Adult; D001924:Brain Concussion; D006801:Humans; D011788:Quality of Life; D055815:Young Adult | Journal of rehabilitation medicine | 2,021 | |
Spinal voltage-gated potassium channel Kv1.3 contributes to neuropathic pain via the promotion of microglial M1 polarization and activation of the NLRP3 inflammasome. | BACKGROUD
Studies have shown that the activation of microglia is the main mechanism of neuropathic pain. Kv1.3 channel is a novel therapeutic target for treating neuroinflammatory disorders due to its crucial role in subsets of microglial cells. As such, it may be involved in the processes of neuropathic pain, however,... | 10.1002/ejp.2059 | 36,440,534 | D000818:Animals; D051381:Rats; D020169:Caspases; D006930:Hyperalgesia; D058847:Inflammasomes; D017628:Microglia; D009437:Neuralgia; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord; D051664:Kv1.3 Potassium Channel | European journal of pain (London, England) | 2,023 | D020169:Caspases; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C573346:Nlrp3 protein, rat; D051664:Kv1.3 Potassium Channel; C496975:Kcna3 protein, rat |
Pars plana vitrectomy for diabetic macular oedema: OCT and functional correlations. | PURPOSE
A prospective study to evaluate the macular structural and functional effects of pars plana vitrectomy (PPV) for persistent diffuse clinically significant macular oedema (CSMO).
METHOD
A total of 12 patients with persistent diffuse CSMO were recruited and underwent assessment including best-corrected visual a... | 10.1038/sj.eye.6701945 | 16,244,647 | D000368:Aged; D003924:Diabetes Mellitus, Type 2; D003930:Diabetic Retinopathy; D005260:Female; D005584:Fovea Centralis; D006801:Humans; D008269:Macular Edema; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:... | Eye (London, England) | 2,006 | |
A modified TALEN-based strategy for rapidly and efficiently generating knockout mice for kidney development studies. | The transcription activator-like effector nucleases (TALENs) strategy has been widely used to delete and mutate genes in vitro. This strategy has begun to be used for in vivo systemic gene manipulation, but not in an organ-specific manner. In this study, we developed a modified, highly efficient TALEN strategy using a ... | 10.1371/journal.pone.0084893 | 24,416,307 | D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus; D004262:DNA Restriction Enzymes; D016368:Frameshift Mutation; D055786:Gene Knockout Techniques; D017930:Genes, Reporter; D057809:HEK293 Cells; D059765:Homologous Recombination; D006720:Homozygote; D006801:Humans; D007668:Kidney; D051379:Mice; D009392:Nephrec... | PloS one | 2,014 | D004262:DNA Restriction Enzymes |
Nephrotoxicity of the 1:1 acrolein-glutathione adduct in the rat. | Previous metabolic studies in rats have suggested in vivo formation of the acrolein-glutathione (acrolein-GSH) adduct following administration of the highly reactive alpha, beta-unsaturated aldehyde acrolein. Early studies by several investigators demonstrated that similar compounds such as alpha, beta-unsaturated alde... | 10.1016/0041-008x(92)90238-n | 1,471,152 | D000171:Acrolein; D000818:Animals; D004221:Disulfiram; D005978:Glutathione; D007555:Isoxazoles; D007674:Kidney Diseases; D007687:Kidney Tubules, Proximal; D008297:Male; D011339:Probenecid; D011720:Pyrazoles; D051381:Rats; D017207:Rats, Sprague-Dawley | Toxicology and applied pharmacology | 1,992 | D007555:Isoxazoles; D011720:Pyrazoles; C031280:pyrazole; D000171:Acrolein; D005978:Glutathione; C006303:acivicin; D011339:Probenecid; D004221:Disulfiram |
[Pharmacotherapy in severe liver failure]. | In severe liver failure pharmacokinetics and pharmacodynamics of different drugs are changed as compared to normals. The disturbances observed may be due to hepatic or extrahepatic mechanism, which allows a rough classification of the different drugs. The hepatic clearance of a drug is dependent upon blood perfusion of... | 7,182,698 | D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D006501:Hepatic Encephalopathy; D006801:Humans; D007700:Kinetics; D008107:Liver Diseases; D008657:Metabolic Clearance Rate; D004364:Pharmaceutical Preparations; D011485:Protein Binding; D012306:Risk | Leber, Magen, Darm | 1,982 | D004364:Pharmaceutical Preparations | |
On stationarity and cointegration of international health expenditure and GDP. | This paper examines stationarity and cointegration of health expenditure and GDP, for a sample of 21 OECD countries using data for the period 1960-1997, by applying a test battery that allows robust inference to be made on the stationarity and cointegration issue. Trend stationarity and no-cointegration are tested usin... | 10.1016/s0167-6296(99)00036-3 | 11,010,235 | D003627:Data Interpretation, Statistical; D019049:Developed Countries; D005102:Health Expenditures; D006302:Health Services Research; D017059:Models, Econometric; D012044:Regression Analysis; D012107:Research Design | Journal of health economics | 2,000 | |
Trichobezoar - A Rare Cause of Abdominal Mass and Gastric Outlet Obstruction. | The authors present the clinical case of a 14-year old girl with weight loss, anorexia, epigastric abdominal pain and postprandial vomiting with 5 months duration. There was a background of trichophagia for 2 years without evidence of alopecia or psychiatric history. The physical examination revealed an epigastric mass... | 10.1016/j.jpge.2015.08.003 | 28,868,431 | GE Portuguese journal of gastroenterology | 2,016 | ||
Reproducible safety and efficacy of atezolizumab plus bevacizumab for HCC in clinical practice: Results of the AB-real study. | BACKGROUND
IMbrave150 has established the superiority of atezolizumab plus bevacizumab over sorafenib in patients with unresectable hepatocellular carcinoma (HCC).
METHODS
We generated a prospectively maintained database including patients treated with atezolizumab plus bevacizumab for unresectable HCC across Europe,... | 10.1016/j.ejca.2022.08.024 | 36,148,739 | D000418:Albumins; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068258:Bevacizumab; D001663:Bilirubin; D006528:Carcinoma, Hepatocellular; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D000077157:Sorafenib; D020246:Venous Thrombosis; D000509:alpha-Fetoproteins | European journal of cancer (Oxford, England : 1990) | 2,022 | D000418:Albumins; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000509:alpha-Fetoproteins; D000068258:Bevacizumab; C000594389:atezolizumab; D000077157:Sorafenib; D001663:Bilirubin |
VAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin regulation at Arabidopsis FLC. | Polycomb (PcG) silencing is crucial for development, but how targets are specified remains incompletely understood. The cold-induced Polycomb Repressive Complex 2 (PRC2) silencing of Arabidopsis thaliana FLOWERING LOCUS C (FLC) provides an excellent system to elucidate PcG regulation. Association of the DNA binding pro... | 10.1038/s41467-022-32897-7 | 36,130,923 | D017360:Arabidopsis; D029681:Arabidopsis Proteins; D002843:Chromatin; D018506:Gene Expression Regulation, Plant; D020868:Gene Silencing; D006657:Histones; D026161:MADS Domain Proteins; D063151:Polycomb Repressive Complex 2; D063146:Polycomb-Group Proteins | Nature communications | 2,022 | D029681:Arabidopsis Proteins; D002843:Chromatin; D006657:Histones; D026161:MADS Domain Proteins; D063146:Polycomb-Group Proteins; D063151:Polycomb Repressive Complex 2 |
Emergence agitation in children undergoing adenotonsillectomy: a comparison of sevoflurane vs. sevoflurane-remifentanil administration. | BACKGROUND
Sevoflurane is widely used in paediatric anaesthesia but frequently causes emergence agitation (EA). This study evaluated whether limiting the sevoflurane concentration by combining remifentanil with sevoflurane reduced the incidence of EA.
METHODS
Eighty-four preschool children scheduled for adenotonsille... | 10.1111/aas.12006 | 23,110,746 | D000233:Adenoidectomy; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002675:Child, Preschool; D003693:Delirium; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D010880:Piperidines; D011183:Postoperative Complicat... | Acta anaesthesiologica Scandinavica | 2,013 | D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D010880:Piperidines; D000077149:Sevoflurane; D000077208:Remifentanil |
Modeling crop residue burning experiments to evaluate smoke emissions and plume transport. | Crop residue burning is a common land management practice that results in emissions of a variety of pollutants with negative health impacts. Modeling systems are used to estimate air quality impacts of crop residue burning to support retrospective regulatory assessments and also for forecasting purposes. Ground and air... | 10.1016/j.scitotenv.2018.01.237 | 29,426,175 | The Science of the total environment | 2,018 | ||
Central nervous system toxoplasmosis in Roller canaries. | Several birds in a flock of 40 Roller canaries (Serinus canaria) from an outdoor aviary in Victoria, Australia, developed central nervous system signs that included blindness, nystagmus, ataxia, and head rotation. Four died, and four were euthanatized. Two euthanatized birds were submitted for microscopic examination o... | 7,794,185 | D000818:Animals; D001315:Australia; D001715:Bird Diseases; D001921:Brain; D002171:Canaries; D002493:Central Nervous System Diseases; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular; D006984:Hypertrophy; D013411:Sulfadiazine; D014122:Toxoplasma; D014124:Toxoplasmosis, Animal; D014295:Trimethoprim | Avian diseases | 1,995 | D013411:Sulfadiazine; D014295:Trimethoprim | |
Expression of clpX, an ATPase subunit of the Clp protease, is heat and cold shock inducible in Lactococcus lactis. | In this study, the clpX gene and surrounding sequences were cloned and sequenced from Lactococcus lactis. The putative clpX gene encodes a 411 amino acid polypeptide with a predicted molecular weight of 45.8 kDa. Analysis of the relative levels of clpX transcript revealed that in addition to a role in proteolysis of he... | 10.3168/jds.S0022-0302(01)74615-2 | 11,518,300 | D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases; D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D001483:Base Sequence; D003080:Cold Temperature; D015925:Cryopreservation; D049071:Endopeptidase Clp; D029968:Escherichia coli Proteins; D015964:Gene Expression Reg... | Journal of dairy science | 2,001 | D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D012697:Serine Endopeptidases; D049071:Endopeptidase Clp; D000251:Adenosine Triphosphatases; C088072:ClpX protein, E coli; D000074183:ATPases Associated with Diverse Cellular Activities |
In vitro cellular uptake of evodiamine and rutaecarpine using a microemulsion. | OBJECTIVE
To investigate the cellular uptake of evodiamine and rutaecarpine in a microemulsion in comparison with aqueous suspensions and tinctures.
MATERIALS AND METHODS
A microemulsion was prepared using the dropwise addition method. Mouse skin fibroblasts were cultured in vitro to investigate the optimal condition... | 10.2147/IJN.S30616 | 22,679,361 | D000818:Animals; D004655:Emulsions; D005347:Fibroblasts; D026121:Indole Alkaloids; D051379:Mice; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells; D053758:Nanoparticles; D010316:Particle Size; D011799:Quinazolines; D012235:Rhodamines | International journal of nanomedicine | 2,012 | D004655:Emulsions; D026121:Indole Alkaloids; D011799:Quinazolines; D012235:Rhodamines; C028632:rutecarpine; C049639:evodiamine; C029773:rhodamine B |
EXPRESSION OF IMMUNOGLOBULIN SEQUENCES HOMOLOGOUS TO ANTI-SARS-CoV-2 ANTIBODIES AND HIV IN CHRONIC LYMPHOCYTIC LEUKEMIA CASES. | BACKGROUND
Identification of epitopes recognized by leukemic B cells could provide insights into the molecular mechanisms of B cell transformation in chronic lymphocytic leukemia (CLL). The aim of this paper was to compare nucleotide sequences of immunoglobulin heavy chain variable region (IGHV) genes in CLL with known... | 10.32471/exp-oncology.2312-8852.vol-44-no-3.18414 | 36,325,706 | D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell; D007143:Immunoglobulin Heavy Chains; D000595:Amino Acid Sequence; D000086402:SARS-CoV-2; D000086382:COVID-19; D007135:Immunoglobulin Variable Region; D015658:HIV Infections; D000998:Antiviral Agents | Experimental oncology | 2,022 | D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D000998:Antiviral Agents |
Adjunctive vagus nerve stimulation for treatment-resistant depression: a preliminary study. | BACKGROUND
This study is the first to assess the safety and therapeutic efficacy of vagus nerve stimulation (VNS) as an adjunctive treatment for Chinese patients suffering from treatment-resistant depression (TRD).
METHODS
A total of seven patients with TRD underwent surgical implantation of a VNS device were followe... | 10.1080/13651501.2021.2019789 | 35,023,429 | D000328:Adult; D006801:Humans; D055536:Vagus Nerve Stimulation; D003863:Depression; D003371:Cough; D016896:Treatment Outcome; D000928:Antidepressive Agents | International journal of psychiatry in clinical practice | 2,022 | D000928:Antidepressive Agents |
2-Amino-9-[(1S,3R,4S)-4-hydr-oxy-3-hydroxy-methyl-2-methyl-enecyclo-pent-yl]-1,9-dihydro-6H-purin-6-one monohydrate. | In the crystal of the title compound, C(12)H(15)N(5)O(3)·H(2)O, the component species are linked by N-H⋯N, N-H⋯O, O-H⋯N and O-H⋯O hydrogen bonds, forming a three-dimesnional network. | 10.1107/S1600536809032966 | 21,577,631 | Acta crystallographica. Section E, Structure reports online | 2,009 | ||
Information coding capacity of cerebellar parallel fibers. | Understanding synaptic connectivity is a prerequisite to gaining insight on how the central nervous system processes information. Cerebellar parallel fibers make an impressive number of synapses with the Purkinje cells. These synapses are the major structural elements of a large information processing system. The objec... | 10.1016/j.brainresbull.2006.01.007 | 16,750,482 | D000818:Animals; D002531:Cerebellum; D001330:Electronic Data Processing; D051379:Mice; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D009412:Nerve Fibers; D011689:Purkinje Cells; D016622:Silver Staining; D013569:Synapses | Brain research bulletin | 2,006 | |
Newer antipsychotics and upcoming molecules for schizophrenia. | BACKGROUND
The management of schizophrenia has seen significant strides over the last few decades, due to the increasing availability of a number of antipsychotics. Yet, the diminished efficacy in relation to the negative and cognitive symptoms of schizophrenia, and the disturbing adverse reactions associated with the ... | 10.1007/s00228-013-1498-4 | 23,545,936 | D014150:Antipsychotic Agents; D003986:Dibenzocycloheptenes; D055808:Drug Discovery; D006576:Heterocyclic Compounds, 4 or More Rings; D006801:Humans; D054833:Isoindoles; D007555:Isoxazoles; D000069056:Lurasidone Hydrochloride; D010879:Piperazines; D010880:Piperidines; D012559:Schizophrenia; D013844:Thiazoles | European journal of clinical pharmacology | 2,013 | D014150:Antipsychotic Agents; D003986:Dibenzocycloheptenes; D006576:Heterocyclic Compounds, 4 or More Rings; D054833:Isoindoles; D007555:Isoxazoles; D010879:Piperazines; D010880:Piperidines; D013844:Thiazoles; C079310:blonanserin; C522667:asenapine; D000069056:Lurasidone Hydrochloride; C081732:iloperidone |
Four PCR primers necessary for the detection of periplasmic nitrate reductase genes in all groups of Proteobacteria and in environmental DNA. | Generic primers are available for detecting bacterial genes required for almost every reaction of the biological nitrogen cycle, the one notable exception being napA (gene for the molybdoprotein of the periplasmic nitrate reductase) encoding periplasmic nitrate reductases. Using an iterative approach, we report the fir... | 10.1042/BST0390321 | 21,265,796 | D001426:Bacterial Proteins; D001483:Base Sequence; D004247:DNA; D005784:Gene Amplification; D006801:Humans; D008969:Molecular Sequence Data; D050901:Nitrate Reductase; D058458:Nitrogen Cycle; D019897:Periplasm; D016133:Polymerase Chain Reaction; D020560:Proteobacteria; D016415:Sequence Alignment; D017422:Sequence Analy... | Biochemical Society transactions | 2,011 | D001426:Bacterial Proteins; D004247:DNA; D050901:Nitrate Reductase |
Emerging role of Gut-microbiota-brain axis in depression and therapeutic implication. | The human body can be considered a superorganism in which it's eukaryotic cells and prokaryotic microorganisms coexist. Almost every organ system of the body lives a symbiotic life with these commensal bacteria. Intestinal microbiota has an important role in shaping, organizing and maintaining mental functions from as ... | 10.1016/j.pnpbp.2020.110138 | 33,075,447 | D000818:Animals; D001921:Brain; D000087502:Brain-Gut Axis; D003863:Depression; D000069196:Gastrointestinal Microbiome; D006801:Humans; D056692:Prebiotics; D019936:Probiotics | Progress in neuro-psychopharmacology & biological psychiatry | 2,021 | D056692:Prebiotics |
Past and current medical states of yusho patients. | A subacute poisoning, "yusho," caused by the ingestion of Kanemi rice oil which had been accidentally contaminated with polychlorinated biphenyls (PCBs), occurred in the western part of Japan in 1968. During the past decade, various clinical symptoms of yusho patients have diminished gradually. However, some of the sym... | 6,425,848 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005506:Food Contamination; D006801:Humans; D008297:Male; D008875:Middle Aged; D009821:Oils; D012275:Oryza; D011078:Polychlorinated Biphenyls | Progress in clinical and biological research | 1,984 | D009821:Oils; D011078:Polychlorinated Biphenyls | |
Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs. | Exposing guinea pigs to toluene diisocyanate (TDI) causes an acute increase in airway responsiveness to inhaled acetylcholine. The mechanism of this increase in airway responsiveness is unknown. Capsaicin-sensitive afferent nerves and the tachykinins they release upon activation are important in controlling bronchomoto... | 10.1164/ajrccm/136.1.43 | 2,440,357 | D000109:Acetylcholine; D000403:Airway Resistance; D000818:Animals; D002211:Capsaicin; D003485:Cyanates; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005070:Evans Blue; D005119:Extravasation of Diagnostic and Therapeutic Materials; D006168:Guinea Pigs; D008297:Male; D009479:Neuropepti... | The American review of respiratory disease | 1,987 | D003485:Cyanates; D009479:Neuropeptides; D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D015320:Tachykinins; D014051:Toluene 2,4-Diisocyanate; D013373:Substance P; D005070:Evans Blue; C038073:substance P, Arg(1)-Pro(2)-Trp(7),(9)-LeuNH(2)(11)-; D000109:Acetylcholine; D002211:Capsaicin |
Roles of cyclophilins in cancers and other organ systems. | Cyclophilins are originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. Many cyclophilins, including CypA, CypB, CypC, CypD, and Cyp40, have been discovered and shown to be ubiquitously distributed in many types of cells and organ systems. Recent investigations have uncovered m... | 10.1007/s00268-004-7812-7 | 15,706,440 | D015703:Antigens, CD; D017209:Apoptosis; D051926:Basigin; D021983:Cyclophilins; D006801:Humans; D008928:Mitochondria; D009369:Neoplasms; D017510:Protein Folding | World journal of surgery | 2,005 | D015703:Antigens, CD; C497886:BSG protein, human; D051926:Basigin; D021983:Cyclophilins |
Intrahepatic delivery of glutathione by conjugation to dextran. | Glutathione was covalently attached to dextran (T-40) by the CNBr activation method. The compound obtained was a water-soluble powder containing 10 (w/w%) glutathione, which was gradually released from the conjugate in aqueous media. Mice depleted of glutathione by treatment with buthionine sulfoximine, a potent inhibi... | 10.1023/a:1015922303051 | 2,482,968 | D000082:Acetaminophen; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003911:Dextrans; D005470:Fluorometry; D005978:Glutathione; D019803:Glutathione Disulfide; D008099:Liver; D008107:Liver Diseases; D008297:Male; D051379:Mice;... | Pharmaceutical research | 1,989 | D003911:Dextrans; D011355:Prodrugs; D000082:Acetaminophen; D005978:Glutathione; D019803:Glutathione Disulfide |
Defence nursing: a force for good care. | Director of army nursing services David Bates has a leading role in defence nursing policy, training, education and research. He ensures defence nurses meet NMC standards while delivering care in demanding, often hostile environments. Col Bates believes that the NHS has much to learn from defence nursing in terms of le... | 10.7748/ns.28.41.20.s26 | 24,916,238 | D008888:Military Nursing; D009740:Nursing Staff; D012956:Societies, Nursing; D013222:State Medicine; D006113:United Kingdom | Nursing standard (Royal College of Nursing (Great Britain) : 1987) | 2,014 | |
[Distribution and species composition of hyporheic macroinvertebrates in a mountain stream]. | Hyporheic macroinvertebrates are an important component of stream ecosystem. The composition and distribution of the hyporheic macroinvertebrates were investigated using artificial substrates in the upper reaches of Heishuitan River in August, December 2013 and April 2014. The results indicated that a total of 27 micro... | 26,785,569 | D000818:Animals; D018533:Biomass; D058448:Biota; D002681:China; D017753:Ecosystem; D007313:Insecta; D007448:Invertebrates; D045483:Rivers; D012621:Seasons | Ying yong sheng tai xue bao = The journal of applied ecology | 2,015 | ||
Time varying causal network reconstruction of a mouse cell cycle. | BACKGROUND
Biochemical networks are often described through static or time-averaged measurements of the component macromolecules. Temporal variation in these components plays an important role in both describing the dynamical nature of the network as well as providing insights into causal mechanisms. Few methods exist,... | 10.1186/s12859-019-2895-1 | 31,142,274 | D000465:Algorithms; D000818:Animals; D002453:Cell Cycle; D059447:Cell Cycle Checkpoints; D004622:Embryo, Mammalian; D005347:Fibroblasts; D016193:G1 Phase; D053263:Gene Regulatory Networks; D018816:Genes, cdc; D051379:Mice; D013997:Time Factors | BMC bioinformatics | 2,019 | |
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. | Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential ... | 10.1371/journal.pone.0020559 | 21,655,234 | D000818:Animals; D002352:Carrier Proteins; D002478:Cells, Cultured; D005727:Ganglia, Spinal; D006632:Histamine; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout; D011537:Pruritus; D015398:Signal Transduction; D050916:TRPV Cation Channels | PloS one | 2,011 | D002352:Carrier Proteins; D008565:Membrane Proteins; C529003:Pirt protein, mouse; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D006632:Histamine |
Infrared thermal imaging as a physiological access pathway: a study of the baseline characteristics of facial skin temperatures. | In this study we examine the baseline characteristics of facial skin temperature, as measured by dynamic infrared thermal imaging, to gauge its potential as a physiological access pathway for non-verbal individuals with severe motor impairments. Frontal facial recordings were obtained from 12 asymptomatic adults in a r... | 10.1088/0967-3334/30/4/N01 | 19,332,894 | D000328:Adult; D019277:Entropy; D005145:Face; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007259:Infrared Rays; D012881:Skin Temperature; D013997:Time Factors | Physiological measurement | 2,009 | |
Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. | Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase, and induce deletion of specific CD8 T cells via Programmed Death Lig... | 10.1371/journal.pone.0087740 | 24,503,860 | D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes; D060890:B7-H1 Antigen; D018414:CD8-Positive T-Lymphocytes; D015815:Cell Adhesion Molecules; D060833:Cellular Microenvironment; D042783:Endothelial Cells; D004729:Endothelium, Lymphatic; D007108:Immune Tolerance; D008198:Lymph Nodes; D053259:Lymphotoxin b... | PloS one | 2,014 | D060890:B7-H1 Antigen; D015815:Cell Adhesion Molecules; D053259:Lymphotoxin beta Receptor; C489082:Madcam1 protein, mouse; D009088:Mucoproteins; D014442:Monophenol Monooxygenase |
Factors influencing surgical treatment decisions for breast cancer: a qualitative exploration of surgeon and patient perspectives. | Background
The rate of mastectomy is much higher in Newfoundland and Labrador than in any other province in Canada, even for women diagnosed at an early stage. In this paper, we present qualitative data from women who have made a decision for surgical treatment and from breast surgeons in an effort to better explicate ... | 10.3747/co.26.4305 | 31,043,830 | D000328:Adult; D001294:Attitude to Health; D001943:Breast Neoplasms; D003657:Decision Making; D005260:Female; D017144:Focus Groups; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009523:Newfoundland and Labrador; D057240:Patient Preference; D010817:Physician-Patient Relations; D066231:Surgeons; D011795:Surve... | Current oncology (Toronto, Ont.) | 2,019 | |
Distribution of vitamin D-dependent calcium-binding protein messenger ribonucleic acid in rat placenta and duodenum. | The vitamin D-dependent calcium-binding protein (CaBP), cholecalcin or calbindin, is one of the best documented molecular expressions of 1,25-dihydroxyvitamin D, the hormonal metabolite of vitamin D. In this report, DNA/RNA hybridization assays have been used to examine cholecalcin (CaBP) mRNA production in the placent... | 10.1210/endo-119-1-176 | 3,459,646 | D000818:Animals; D002135:Calcium-Binding Proteins; D004247:DNA; D004386:Duodenum; D005260:Female; D005819:Genetic Markers; D009693:Nucleic Acid Hybridization; D010920:Placenta; D011247:Pregnancy; D012333:RNA, Messenger; D051381:Rats; D011919:Rats, Inbred Strains; D064030:S100 Calcium Binding Protein G | Endocrinology | 1,986 | D002135:Calcium-Binding Proteins; D005819:Genetic Markers; D012333:RNA, Messenger; D064030:S100 Calcium Binding Protein G; D004247:DNA |
Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis. | BACKGROUND
Increments in inflammatory indicators and low levels of physical activity are correlated to the expansion of the metabolic syndrome (MetS).
OBJECTIVE
The purpose of this study was to establish if exercise training ameliorates inflammatory status in MetS patients.
DATA SOURCES
PubMed, CINAHL, and Medline,... | 10.1177/1099800420958068 | 32,938,197 | D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D002097:C-Reactive Protein; D016207:Cytokines; D015444:Exercise; D006801:Humans; D007249:Inflammation; D024821:Metabolic Syndrome; D055070:Resistance Training | Biological research for nursing | 2,021 | D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D016207:Cytokines; D002097:C-Reactive Protein |
Newborn care practices and health seeking behavior in urban slums and villages of Anand, Gujarat. | Health status of neonates in urban slums has not been studied in smaller towns. A questionnaire was administered to 154 families of 10 urban slums of Anand (population - 197351) and 160 families from 6 villages of Anand district. The socioeconomic and education status of the slum dwellers versus rural participants were... | 10.1007/s13312-013-0116-y | 23,024,104 | D001942:Breast Feeding; D015438:Health Behavior; D007722:Health Knowledge, Attitudes, Practice; D006700:Home Childbirth; D006801:Humans; D007194:India; D007224:Infant Care; D007231:Infant, Newborn; D016015:Logistic Models; D010342:Patient Acceptance of Health Care; D011204:Poverty Areas; D012424:Rural Population; D0145... | Indian pediatrics | 2,013 | |
Atomoxetine treatment in children and adolescents with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder. | OBJECTIVE
To examine (1) moderating effects of oppositional defiant disorder (ODD) on attention-deficit/hyperactivity disorder (ADHD) treatment response and (2) responses of ODD symptoms to atomoxetine.
METHOD
Children and adolescents (ages 8-18) with ADHD were treated for approximately 8 weeks with placebo or atomox... | 10.1097/00004583-200503000-00008 | 15,725,968 | D000293:Adolescent; D000069445:Atomoxetine Hydrochloride; D001289:Attention Deficit Disorder with Hyperactivity; D019958:Attention Deficit and Disruptive Behavior Disorders; D002648:Child; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D... | Journal of the American Academy of Child and Adolescent Psychiatry | 2,005 | D011437:Propylamines; D000069445:Atomoxetine Hydrochloride; D009638:Norepinephrine |
Disulfide exchange in hydrogen-bonded cyclic assemblies: stereochemical self-selection by double dynamic chemistry. | Stereoselective cyclization of cystine-based bifunctional 2-ureido-4[1H]-pyrimidinone derivatives in CDCl(3) solutions was demonstrated by (1)H NMR spectroscopy. Thiolate-catalyzed disulfide exchange in solution led to the equilibration of different diastereomers of 1. At low concentrations, where formation of cyclic a... | 10.1021/jo0501238 | 16,018,671 | D002384:Catalysis; D003500:Cyclization; D003553:Cystine; D003903:Deuterium; D004220:Disulfides; D006859:Hydrogen; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D011744:Pyrimidinones; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds; D013997:Time Factors | The Journal of organic chemistry | 2,005 | C109276:2-ureido-4-pyrimidone; D004220:Disulfides; D011744:Pyrimidinones; D013438:Sulfhydryl Compounds; D003553:Cystine; D006859:Hydrogen; D003903:Deuterium |
[The abdominal flap-graft for coverage of soft tissue defects of the dorsum of hand and fingers in burn patients. Six cases reports]. | We report six cases of abdominal flap-graft used to cover post-burn soft tissue defects of hands. The technique used was first described by Colson and is applied in our study to an abdominal donor site. Debulking of the flap at the time of elevation resulted in a skin quality as good as a full thickness graft without j... | 10.1016/j.anplas.2004.11.011 | 15,820,601 | D000293:Adolescent; D000328:Adult; D002056:Burns; D002648:Child; D002675:Child, Preschool; D005260:Female; D006230:Hand Injuries; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D016038:Skin Transplantation; D017695:Soft Tissue Injuries; D013524:Surgical Flaps | Annales de chirurgie plastique et esthetique | 2,005 | |
Concerning the preparation and use of substances with a magnetic susceptibility equal to the magnetic susceptibility of air. | In this work it is demonstrated that the susceptibility of diamagnetic substances, such as water and agarose gel, can easily be tuned to the susceptibility of air by the addition of a proper amount of strongly paramagnetic ions, in this case 16.6 +/- 0.1 mM holmium(III). The resultant air-equivalent substances are show... | 10.1002/mrm.21069 | 17,041,881 | D000388:Air; D001672:Biocompatible Materials; D003287:Contrast Media; D006695:Holmium; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008422:Materials Testing; D019047:Phantoms, Imaging | Magnetic resonance in medicine | 2,006 | D001672:Biocompatible Materials; D003287:Contrast Media; D006695:Holmium |
Mussel-inspired preparation of layered double hydroxides based polymer composites for removal of copper ions. | A novel ternary composite consisting of Mg/Al layered double hydroxides (LDH), polydopamine (PDA) and poly(methyl vinyl ether-alt-maleic anhydride) (PMVE-MA) was fabricated by a facile combination of mussel-inspired chemistry and a ring-opening reaction. Dopamine can serve as a "minimalist mimic" of mussel adhesive pro... | 10.1016/j.jcis.2018.08.064 | 30,172,152 | Journal of colloid and interface science | 2,019 | ||
Congenital left ventricular diverticulum: A rare cause of cardiac arrhythmia. | Congenital left ventricular diverticula are rare cardiac malformations that usually remain asymptomatic. However, life-threatening complications as ventricular arrhythmias, systemic embolism, spontaneous rupture and development of valvular regurgitation, are described. Diagnosis is based on excluding coronary artery di... | 10.1111/jocs.14464 | 32,065,468 | D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac; D058070:Asymptomatic Diseases; D004240:Diverticulum; D005260:Female; D006331:Heart Diseases; D006352:Heart Ventricles; D006801:Humans; D008279:Magnetic Resonance Imaging; D016896:Treatment Outcome | Journal of cardiac surgery | 2,020 |
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