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Influence of supplemental condensed tannins on initial 112-d feedlot growth-performance and characteristics of digestion of calf-fed Holstein steers. | In experiment 1, 150 calf-fed Holstein steers (119 ± 6 kg) were used to evaluate the effects of level of supplemental condensed tannin (0, 14, and 28 g/kg diet DM) in a conventional steam-flaked corn-based growing-finishing diet on feedlot growth performance. There were no treatment effects on growth performance during... | 10.1093/tas/txac024 | 35,356,230 | Translational animal science | 2,022 | ||
Evaluation of some plants used in Turkish folk medicine against parasitic infections for their in vivo anthelmintic activity. | Ethanolic and aqueous extracts obtained from nine plant species from seven families selected depending on their use in Turkish folk medicine, including Citrillus lanatus (Thunb.) Matsum. (seed), Jasminum fruticans L. (branches), Juniperus drupacea Labill. (fruits), Juniperus nana L. (fruit and leaves), Juniperus oxcyce... | 10.1016/j.jep.2006.05.003 | 16,790,330 | D000818:Animals; D000871:Anthelmintics; D016208:Databases, Factual; D000431:Ethanol; D031660:Jasminum; D008297:Male; D008519:Medicine, Traditional; D027541:Mentha; D051379:Mice; D010124:Oxyuroidea; D010273:Parasitic Diseases, Animal; D008517:Phytotherapy; D028223:Pinus; D010936:Plant Extracts; D018514:Plant Structures;... | Journal of ethnopharmacology | 2,006 | D000871:Anthelmintics; D010936:Plant Extracts; D014867:Water; D000431:Ethanol |
Quality of the ICD-11 Beta Draft from the German Perspective: Evaluation Based on the Alphabet of ICD-10-GM 2017. | OBJECTIVES
The German Association for Medical Informatics, Biometry and Epidemiology implemented a field test for the ICD-11 Beta Draft. Aim was to analyze completeness and appropriateness of the ICD-11 Beta Draft in its entire breadth.
METHODS
Starting point was the synonym thesaurus ("Alphabet") of the German modif... | 10.3414/ME17-01-0133 | 30,248,707 | D000068598:Data Accuracy; D005858:Germany; D006801:Humans; D038801:International Classification of Diseases; D015588:Observer Variation; D015203:Reproducibility of Results | Methods of information in medicine | 2,018 | |
Bilateral priming accelerates recovery of upper limb function after stroke: a randomized controlled trial. | BACKGROUND AND PURPOSE
The ability to live independently after stroke depends on the recovery of upper limb function. We hypothesized that bilateral priming with active-passive movements before upper limb physiotherapy would promote rebalancing of corticomotor excitability and would accelerate upper limb recovery at th... | 10.1161/STROKEAHA.113.003537 | 24,178,916 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001132:Arm; D002545:Brain Ischemia; D004185:Disability Evaluation; D004558:Electric Stimulation; D004576:Electromyography; D023381:Endpoint Determination; D005260:Female; D007839:Functional Laterality; D006225:Hand; D006801:Humans; D... | Stroke | 2,014 | |
Cognitive and motor slowing mediate the relationship between depression and falls in multiple sclerosis patients. | OBJECTIVE
Given the limited research concerning the relationship between depression and falls in multiple sclerosis (MS), this study aimed to examine the direct and indirect association between fall history and depressive symptoms.
METHODS
One hundred and forty seven MS patients had completed at least one neuropsycho... | 10.1016/j.msard.2021.102808 | 33,596,493 | D003071:Cognition; D003863:Depression; D006801:Humans; D009103:Multiple Sclerosis; D009483:Neuropsychological Tests | Multiple sclerosis and related disorders | 2,021 | |
Vascular endothelial growth factor is expressed in human fetal growth cartilage. | Angiogenesis is a crucial event in endochondral ossification. Chemoattractants and mitogens for endothelial cells (such as basic fibroblast growth factor [bFGF] and transforming growth factor beta [TGF-beta]), which act as local regulators of the process, are synthesized by chondrocytes under several stimuli and in rel... | 10.1359/jbmr.2000.15.3.534 | 10,750,568 | D017398:Alternative Splicing; D002117:Calcitriol; D002356:Cartilage; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D004261:DNA Replication; D016228:Endothelial Growth Factors; D004730:Endothelium, Vascular; D004815:Epidermal Growth Factor; D005326:Fetal Proteins; D016222:F... | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 2,000 | D017077:Culture Media, Conditioned; D016228:Endothelial Growth Factors; D005326:Fetal Proteins; D008222:Lymphokines; D012333:RNA, Messenger; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblas... |
p53 protein overexpression in relation to risk factors for breast cancer. | To investigate whether breast tumors developing through a pathway with p53 protein overexpression (p53+) show different risk factor associations compared with breast tumors without p53 overexpression (p53-), the authors determined p53 overexpression in tissue sections of 528 patients with invasive breast cancer by usin... | 10.1093/oxfordjournals.aje.a008862 | 8,916,503 | D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms; D016022:Case-Control Studies; D016001:Confidence Intervals; D003276:Contraceptives, Oral; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007774:Lactation; D008875:Middle Aged; D009154:Mutation; D016017:Odds Ratio; D012307:Risk Factors; D01399... | American journal of epidemiology | 1,996 | D003276:Contraceptives, Oral; D016159:Tumor Suppressor Protein p53 |
Augmented early aged neutrophil infiltration contributes to late remodeling post myocardial infarction. | Neutrophils oscillate in number and phenotype after being released from bone marrow. Myocardial infarction (MI) outcome is associated with the time-of-day of ischemia onset. However, the underlying contributive factors of neutrophils to cardiac remodeling post MI remain unknown. We examined neutrophil infiltration into... | 10.1016/j.mvr.2021.104268 | 34,728,225 | D000818:Animals; D000906:Antibodies; D054426:Chemokine CXCL2; D002940:Circadian Rhythm; D004195:Disease Models, Animal; D005355:Fibrosis; D008297:Male; D008810:Mice, Inbred C57BL; D009203:Myocardial Infarction; D009206:Myocardium; D020556:Neutrophil Infiltration; D009504:Neutrophils; D019718:Receptors, CXCR4; D023063:R... | Microvascular research | 2,022 | D000906:Antibodies; C514936:CXCR4 protein, mouse; D054426:Chemokine CXCL2; C404915:Cxcl2 protein, mouse; C000707068:Cxcr2 protein, mouse; D019718:Receptors, CXCR4; D023063:Receptors, Interleukin-8B |
Asbestos-induced lung disease. | This review attempts to deal with two major questions concerning asbestos-induced lung disease: How does inhaled asbestos cause cell proliferation and fibrosis? and Will there continue to be risk from exposure to asbestos in schools and public buildings? The first is a scientific question that has spawned many interest... | 10.1289/ehp.9310021 | 8,354,168 | D001194:Asbestos; D002455:Cell Division; D004781:Environmental Exposure; D006801:Humans; D008171:Lung Diseases; D011658:Pulmonary Fibrosis; D012307:Risk Factors; D012574:Schools | Environmental health perspectives | 1,993 | D001194:Asbestos |
Do community pharmacists in Nepal have a role in adverse drug reaction reporting systems? | Community pharmacies in Nepal serve both rural and urban populations and are an integral part of the Nepalese healthcare system. These community pharmacies are run by non-pharmacist professionals with orientation training on pharmacology and drug dispensing. Graduate pharmacists' involvement in community pharmacy will ... | 10.4066/AMJ.2013.1544 | 23,483,017 | The Australasian medical journal | 2,013 | ||
Neuropsychiatric Aspects of Traumatic Brain Injury. | Traumatic brain injury (TBI) may produce a variety of neuropsychiatric problems, including impaired cognition, depression, mania, affective lability, irritability, anxiety, and psychosis. Despite the common occurrence of these symptoms following TBI, there are relatively few studies that provide clear guidance regardin... | 10.1007/s11940-000-0017-y | 11,096,746 | Current treatment options in neurology | 2,000 | ||
The Di Giacomo technique: simplified suture passing in SLAP repair. | A 30 degrees arthroscope is introduced via the posterior soft spot portal, and an anterosuperior portal is created with the use of a 7-mm disposable cannula. The anterosuperior portal is used for instrumentation. An 18-gauge spinal needle is passed via the portal of Neviaser and the rotator cuff into arthroscopic view ... | 10.1016/j.arthro.2006.07.045 | 17,418,338 | D001182:Arthroscopy; D006801:Humans; D017006:Rotator Cuff; D012680:Sensitivity and Specificity; D012785:Shoulder Joint; D053441:Suture Anchors; D013536:Suture Techniques | Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association | 2,007 | |
Engineering mesenchymal stem cells for regenerative medicine and drug delivery. | Researchers have applied mesenchymal stem cells (MSC) to a variety of therapeutic scenarios by harnessing their multipotent, regenerative, and immunosuppressive properties with tropisms toward inflamed, hypoxic, and cancerous sites. Although MSC-based therapies have been shown to be safe and effective to a certain degr... | 25,770,356 | D000818:Animals; D001861:Bone Regeneration; D060846:Cell Engineering; D016503:Drug Delivery Systems; D005818:Genetic Engineering; D006801:Humans; D007249:Inflammation; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D009203:Myocardial Infarction; D044968:Regenerative Medicine; D057170:Tra... | Methods (San Diego, Calif.) | 2,015 | ||
Improved flagging rates on the Sysmex XE-5000 compared with the XE-2100 reduce the number of manual film reviews and increase laboratory productivity. | Hematology analyzers generate suspect flags in the presence of abnormal cells. False-positive rates for flags are high on all analyzers. Sysmex, Kobe, Japan, has developed new software for its XE-5000 with improved algorithms for flagging blast cells, abnormal lymphocytes or lymphoblasts, and atypical lymphocytes. This... | 10.1309/AJCPDLR4KGKAFW4W | 21,757,605 | D000465:Algorithms; D004526:Efficiency; D005189:False Positive Reactions; D019337:Hematologic Neoplasms; D006405:Hematology; D006801:Humans; D007753:Laboratories; D007958:Leukocyte Count; D012680:Sensitivity and Specificity; D012984:Software | American journal of clinical pathology | 2,011 | |
Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance. | The androgen receptor (AR) antagonist enzalutamide is one of the principal treatments for men with castration-resistant prostate cancer (CRPC). However, not all patients respond, and resistance mechanisms are largely unknown. We hypothesized that genomic and transcriptional features from metastatic CRPC biopsies prior ... | 10.1073/pnas.1922207117 | 32,424,106 | D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents; D001549:Benzamides; D019008:Drug Resistance, Neoplasm; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles; D010669:Phenylthiohydantoin; D017430:Prostate-Specific Antigen; D064129:Prostatic Neoplas... | Proceedings of the National Academy of Sciences of the United States of America | 2,020 | D000970:Antineoplastic Agents; D001549:Benzamides; D009570:Nitriles; D011944:Receptors, Androgen; D010669:Phenylthiohydantoin; C540278:enzalutamide; D017430:Prostate-Specific Antigen |
Innate Cancer Immunoediting. | Immune cells detect and destroy cancer cells; however, very early changes in cancer genome and phenotype coupled with immune system selection cause escape variant survival in a process called cancer immunoediting. Although adaptive immunity is important for this process, the report by Kubick et al. provides novel insig... | 10.1016/j.jid.2019.09.015 | 32,200,878 | D056704:Adaptive Immunity; D006801:Humans; D000069416:Intravital Microscopy; D009369:Neoplasms; D010641:Phenotype | The Journal of investigative dermatology | 2,020 | |
Association of Oral Health with Multimorbidity among Older Adults: Findings from the Longitudinal Ageing Study in India, Wave-1, 2017-2019. | India is witnessing an increase in the prevalence of multimorbidity. Oral health is related to overall health but is seldom included in the assessment of multimorbidity. Hence, this study aimed to estimate the prevalence of oral morbidity and explore its association with physical multimorbidity using data from Longitud... | 10.3390/ijerph182312853 | 34,886,581 | D000368:Aged; D000375:Aging; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D006801:Humans; D007194:India; D000076322:Multimorbidity; D009909:Oral Health; D015995:Prevalence | International journal of environmental research and public health | 2,021 | |
Simultaneous Multiple-Stages Mpox Genital Lesions on the Same Site in a Traveler to Greece: A Case Report. | A 47-year-old Caucasian traveller from an mpox (formerly monkeypox and also best suited abbreviated MPX)-endemic country was referred for a skin rash, of recent onset, confined to the genital area. The rash consisted of erythematous umbilicated papules, vesicles and pustules with a characteristic white ring. The lesion... | 10.3390/vaccines11050901 | 37,243,005 | Vaccines | 2,023 | ||
Effects of media portrayals of alleged malpractice in psychiatry and response strategies to mitigate reputational damage: Randomized controlled trial. | Media allegations about malpractice in psychiatry are not uncommon, but little is known about their effects and how clinic management can effectively mitigate reputational damage. This study explored the impact of footage from a TV documentary raising allegations against a psychiatric clinic and assessed the effectiven... | 10.1016/j.jpsychires.2021.04.038 | 33,965,733 | D000328:Adult; D003146:Communications Media; D006801:Humans; D008318:Malpractice; D011570:Psychiatry | Journal of psychiatric research | 2,021 | |
Mitochondrial mutations in protein coding genes of respiratory chain including complexes IV, V, and mt-tRNA genes are associated risk factors for congenital heart disease. | Most studies aiming at unraveling the molecular events associated with cardiac congenital heart disease (CHD) have focused on the effect of mutations occurring in the nuclear genome. In recent years, a significant role has been attributed to mitochondria for correct heart development and maturation of cardiomyocytes. M... | 10.17179/excli2022-5298 | 36,483,916 | EXCLI journal | 2,022 | ||
The consequences of positive and negative perceptual identification. | This study tested the consequences of positive and negative perceptual identification under conditions where the other person (C) represented an ideal or threatening aspect of the Ss' identity. One hundred male students (17 to 25 years of age) participated in the experiment, which followed a 2 X 2 X 2 factorial design.... | 10.1080/00223980.1976.9921369 | 1,003,331 | D006801:Humans; D007062:Identification, Psychological; D007100:Imitative Behavior; D007398:Interpersonal Relations; D007600:Judgment; D008297:Male; D012649:Self Concept; D012928:Social Desirability; D014705:Verbal Behavior | The Journal of psychology | 1,976 | |
The impact of a high fat diet on bones: potential mechanisms. | A high-fat diet (HFD) is defined as a diet that contains lipids that account for more than 30% of the total energy intake, and current research has documented cases with intakes as high as 45% and 60%. There is a view that patients who have a tendency to consume a HFD are more susceptible to various kinds of diseases, ... | 10.1039/d0fo02664f | 33,443,523 | D000818:Animals; D015519:Bone Density; D001842:Bone and Bones; D059305:Diet, High-Fat; D000069196:Gastrointestinal Microbiome; D006801:Humans; D010024:Osteoporosis | Food & function | 2,021 | |
Anisotropic Cardiac Conduction. | Anisotropy is the property of directional dependence. In cardiac tissue, conduction velocity is anisotropic and its orientation is determined by myocyte direction. Cell shape and size, excitability, myocardial fibrosis, gap junction distribution and function are all considered to contribute to anisotropic conduction. I... | 10.15420/aer.2020.04 | 33,437,488 | Arrhythmia & electrophysiology review | 2,020 | ||
Differentiation of bladder cancer stages using the vesical imaging -reporting and data system and apparent diffusion coefficient. | Background
T stage is closely related to the treatment and prognosis of patients with bladder cancer (BC). However, preoperative T staging is still challenging. Multiparametric magnetic resonance imaging (mpMRI) may be valuable. This study was performed to explore the value of the Vesical Imaging-Reporting and Data Sys... | 10.21037/qims-22-1184 | 37,581,052 | Quantitative imaging in medicine and surgery | 2,023 | ||
Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort. | (1) Background: Prioritization of patients for liver transplantation in Germany relies on the MELD (model for end-stage liver disease) scoring system that does not consider the patient's sex. Many studies have shown that women are disadvantaged by the MELD score. Using a large patient cohort from a German liver transpl... | 10.3390/jpm13060963 | 37,373,952 | Journal of personalized medicine | 2,023 | ||
Emergency pacing and subsequent permanent pacemaker implantation in a premature infant of 1770 g with a follow-up of 6 years. | We report successful emergency pacing followed by permanent pacemaker implantation due to complete block in an otherwise healthy premature infant of 1,770 g. Via the umbilical vein a temporary bipolar pacing lead was placed in the right ventricle. The lack of spontaneous improvement warranted implantation of a permanen... | 10.1007/s002460010112 | 10,982,710 | D002304:Cardiac Pacing, Artificial; D004638:Emergency Treatment; D005500:Follow-Up Studies; D006327:Heart Block; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010138:Pacemaker, Artificial; D016896:Treatment Outcome; D014471:Umbilical Veins | Pediatric cardiology | 2,000 | |
Potential roles for vitamins E and C in combination in modulating exhaustive swimming and high altitude-associated lung injury in rats. | OBJECTIVE
To evaluate and compare the potential role of vitamins E and C in protecting against acute swimming induced lung damage at different altitudes.
METHODS
The study was carried out between January and March 2011. Eighteen male rats were bred and reared at either high altitude in Abha city or low altitude in ... | 22,485,230 | D000531:Altitude; D000818:Animals; D001205:Ascorbic Acid; D002374:Catalase; D005978:Glutathione; D008168:Lung; D055370:Lung Injury; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase; D013550:Swimming; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E | Saudi medical journal | 2,012 | D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid | |
A mitochondria-targeting near-infrared fluorescent probe for imaging hypochlorous acid in cells. | Hypochlorous acid (HOCl), as an important reactive oxygen species (ROS), plays an important role in various pathological and physiological processes. Therefore, it is of great significance to identify and detect HOCl in organisms. Herein, a mitochondria-targeting near-Infrared fluorescent probe (CVS) has been designed ... | 10.1016/j.talanta.2021.122152 | 33,676,701 | D005453:Fluorescence; D005456:Fluorescent Dyes; D006997:Hypochlorous Acid; D008247:Lysosomes; D008928:Mitochondria; D061848:Optical Imaging | Talanta | 2,021 | D005456:Fluorescent Dyes; D006997:Hypochlorous Acid |
Mini-Review: The MSA transcriptome. | Multiple system atrophy (MSA) is an atypical parkinsonism that rapidly affects motor ability and autonomic function, leaving patients wheelchair-bound and dependent for daily activities in 3-5 years. Differential diagnosis is challenging as cases may resemble Parkinson's disease or other ataxic syndromes depending on t... | 10.1016/j.neulet.2020.135586 | 33,352,281 | D057890:Epigenomics; D006801:Humans; D035683:MicroRNAs; D019578:Multiple System Atrophy; D017096:Prion Diseases; D059467:Transcriptome | Neuroscience letters | 2,021 | D035683:MicroRNAs |
Application of Challenging Learning Based on Human-Computer Interaction under Machine Vision in Vocational Undergraduate Colleges. | Science and technology have progressed in recent years, the deepening of talent education, a challenging learning method of human-computer interaction has gradually emerged. Human-Computer Interaction (HCI for short) is the communication and interaction between humans and machines. This essay aims to apply the challeng... | 10.1155/2022/4667387 | 36,268,158 | D006801:Humans; D008297:Male; D005260:Female; D007858:Learning; D013334:Students; D014495:Universities; D003201:Computers | Computational intelligence and neuroscience | 2,022 | |
Quality of life 6 and 18 months after mild traumatic brain injury in early childhood: An exploratory study of the role of genetic, environmental, injury, and child factors. | Mild traumatic brain injury (mTBI) in early childhood is prevalent, and some children may be at risk for short- and long-term difficulties that could affect quality of life (QoL). Despite growing efforts to understand associations between potential risk factors and outcomes after injury, prognosis is elusive and lacks ... | 10.1016/j.brainres.2020.147061 | 32,818,528 | D001924:Brain Concussion; D019208:Brain-Derived Neurotrophic Factor; D002675:Child, Preschool; D003071:Cognition; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009483:Neuropsychological Tests; D011788:Quality of Life | Brain research | 2,020 | D019208:Brain-Derived Neurotrophic Factor |
Observation of HOCl generation associated with diabetic cataract using a highly sensitive fluorescent probe. | Diagnosis of diabetic cataract (DC) in the early stage is of great significance for drug intervention and surgery circumvention for DC patients. However, the lack of reliable imaging tools greatly limits the diagnosis of early DC. In this context, a fluorescent probe BBPy for hypochlorous acid (HOCl) is presented based... | 10.1016/j.saa.2022.121385 | 35,597,158 | D002386:Cataract; D003920:Diabetes Mellitus; D005456:Fluorescent Dyes; D006801:Humans; D006997:Hypochlorous Acid; D061848:Optical Imaging; D010084:Oxidation-Reduction | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy | 2,022 | D005456:Fluorescent Dyes; D006997:Hypochlorous Acid |
The effects of overnight orthokeratology lens wear on corneal thickness. | PURPOSE
To investigate corneal thickness changes during overnight orthokeratology with reverse-geometry rigid gas-permeable (RGP) contact lenses worn over a 3-month period.
METHODS
Eighteen young adult subjects with low myopia (<or=4.00 D) were fitted with reverse-geometry lenses (BE; UltraVision Pty. Ltd., Brisbane,... | 10.1167/iovs.02-0680 | 12,766,051 | D000328:Adult; D003261:Contact Lenses; D003319:Corneal Stroma; D019573:Epithelium, Corneal; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia; D012029:Refraction, Ocular; D014792:Visual Acuity | Investigative ophthalmology & visual science | 2,003 | |
Formation of methionine sulfoxide-containing specific forms of oxidized high-density lipoproteins. | Atherosclerosis is characterized by the accumulation of both lipoprotein-derived lipids and inflammatory cells in the affected vascular wall that results in a state of heightened oxidative stress and that is reflected by the accumulation of oxidized lipoproteins. Circulating oxidized low-density lipoprotein (oxLDL) is ... | 10.1016/j.bbapap.2004.11.003 | 15,680,225 | D008077:Lipoproteins, LDL; D008715:Methionine; D010084:Oxidation-Reduction | Biochimica et biophysica acta | 2,005 | D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D008715:Methionine; C013111:methionine sulfoxide |
Retraction: Collecting and measuring nociceptive and inflammatory mediators in surgical wounds. | The article Collecting and Measuring Nociceptive and Inflammatory Mediators in Surgical Wounds, has been retracted at the request of the authors due to duplication of text in J Pain (Carvalho B, Clark DJ, Angst MS (2008) Local and Systemic Release of Cytokines, Nerve Growth Factor, Prostaglandin E2, and Substance P in ... | 22,722,889 | Journal of visualized experiments : JoVE | 2,012 | |||
Expression of placental growth factor mRNA in preeclampsia. | BACKGROUND
Preeclampsia (PE) is a serious complication of pregnancy with hallmarks of incomplete placentation, placental ischemia and endothelial dysfunction. Imbalance between vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors play important role in pathophysiology of PE.
OB... | 28,580,450 | International journal of reproductive biomedicine | 2,017 | |||
The effect of iron overload on in vitro HIV-1 infection. | BACKGROUND
It has been shown that Fe is required by HIV-infected cells for production of viral particles. Excess iron in the cell is detrimental to the host but beneficial to the pathogen.
OBJECTIVES
Here, we investigated the effect of excess Fe (overload) and chelation of the metal on in vitro HIV infection by asses... | 10.1016/j.jcv.2004.09.011 | 15,567,100 | D002470:Cell Survival; D015658:HIV Infections; D015497:HIV-1; D007376:Interleukin-2; D007501:Iron; D007502:Iron Chelating Agents; D014779:Virus Replication | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology | 2,004 | D007376:Interleukin-2; D007502:Iron Chelating Agents; D007501:Iron |
Healing properties of allograft from alendronate-treated animal in lumbar spine interbody cage fusion. | This study investigated the healing potential of allograft from bisphosphonate-treated animals in anterior lumbar spine interbody fusion. Three levels of anterior lumbar interbody fusion with Brantigan cages were performed in two groups of five landrace pigs. Empty Brantigan cages or cages filled with either autograft ... | 10.1007/s00586-004-0771-8 | 15,248,057 | D019386:Alendronate; D000704:Analysis of Variance; D000818:Animals; D001707:Biopsy, Needle; D016025:Bone Transplantation; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D008159:Lumbar Vertebrae; D011897:Random Allocation; D012680:Sensitivity and Specificity; D013123:Spinal Fusion; D018709... | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society | 2,005 | D019386:Alendronate |
Evaluation of Sodium (23Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer's Disease. | BACKGROUND/AIM
Sodium (23Na) MR imaging is a noninvasive MRI technique that has been shown to be sensitive to visualize biochemical information about tissue viability, their cell integrity, and cell function in various studies. The aim of this study was to evaluate differences in regional brain 23Na signal intensity be... | 10.21873/invivo.12275 | 33,402,493 | D000544:Alzheimer Disease; D015415:Biomarkers; D001921:Brain; D060825:Cognitive Dysfunction; D006801:Humans; D008279:Magnetic Resonance Imaging; D012964:Sodium | In vivo (Athens, Greece) | 2,021 | D015415:Biomarkers; D012964:Sodium |
Understanding Reasons for HIV Late Diagnosis: A Qualitative Study Among HIV-Positive Individuals in Amsterdam, The Netherlands. | Since the introduction of effective anti-retroviral therapy, early diagnosis and treatment of HIV have become increasingly important from individual and public health perspectives. People who are diagnosed with a CD4 count below 350 cells/µL blood are today considered to be "late" diagnoses. In an effort to understand ... | 10.1007/s10461-021-03239-3 | 33,788,120 | D018791:CD4 Lymphocyte Count; D057210:Delayed Diagnosis; D015658:HIV Infections; D006801:Humans; D009426:Netherlands; D036301:Qualitative Research | AIDS and behavior | 2,021 | |
Severity, manifestations, and consequences of violence among pregnant adolescents. | PURPOSE
To examine the severity, manifestations, and consequences of prenatal violence among adolescent and adult participants in a county health department prenatal care coordination program.
METHODS
The prospective cohort study design included all Medicaid-eligible program participants from 1994 to 1996. Care coord... | 10.1016/s1054-139x(00)00154-3 | 11,137,907 | D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D016015:Logistic Models; D009657:North Carolina; D011247:Pregnancy; D011256:Pregnancy Outcome; D011253:Pregnancy in Adolescence; D011295:Prenatal Care; D015995:Prevalence; D011446:Prospective Studies... | The Journal of adolescent health : official publication of the Society for Adolescent Medicine | 2,001 | |
Restricted expression of calcium-binding protein S100A5 in human kidney. | Reverse transcription--polymerase chain reaction (RT-PCR) identified the expression of calcium-binding protein S100A5 in the noncancerous parts of resected samples from renal cell carcinoma (RCC) patients (n = 7) but not in the carcinoma lesions. Rabbit anti-S100A5 antibody immunohistochemically detected the antigen in... | 10.1006/bbrc.2002.6494 | 11,855,835 | D002135:Calcium-Binding Proteins; D002292:Carcinoma, Renal Cell; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney; D007680:Kidney Neoplasms; D007684:Kidney Tubules; D009928:Organ Specificity; D012333:RNA, Messenger; D009418:S100 Proteins | Biochemical and biophysical research communications | 2,002 | D002135:Calcium-Binding Proteins; D012333:RNA, Messenger; D009418:S100 Proteins; C082355:S100A5 protein, human |
Multiple entrained oscillator model of food anticipatory circadian rhythms. | For many animal species, knowing when to look for food may be as important as knowing where to look. Rats and other species use a feeding-responsive circadian timing mechanism to anticipate, behaviorally and physiologically, a predictable daily feeding opportunity. How this mechanism for anticipating a daily meal accom... | 10.1038/s41598-022-13242-w | 35,661,783 | D000818:Animals; D002940:Circadian Rhythm; D005247:Feeding Behavior; D005502:Food; D005508:Food Deprivation; D051381:Rats; D013493:Suprachiasmatic Nucleus | Scientific reports | 2,022 | |
Color and phenolic compounds of a young red wine. Influence of wine-making techniques, storage temperature, and length of storage time. | The purpose of this work was to determine the influence of vinification technique (maceration temperature and clarification method), storage temperature, and length of storage time on the phenolic compounds and color of young red wines. Multivariate analysis of variance and principal component analysis pointed to signi... | 10.1021/jf9902548 | 10,725,142 | D000704:Analysis of Variance; D003116:Color; D005519:Food Preservation; D006801:Humans; D010636:Phenols; D013696:Temperature; D013997:Time Factors; D014920:Wine | Journal of agricultural and food chemistry | 2,000 | D010636:Phenols |
Human mutL homolog 1 expression characteristic and prognostic effect on patients with sporadic colorectal cancer. | The aim of the present study was to analyze the relationship between aberrant human mutL homolog 1 (hMLH1) expression and clinicopathological parameters of patients with sporadic colorectal cancer, and to explore the prognostic effect of aberrant hMLH1 expression in these patients. The relationship was measured by chi-... | 26,770,629 | International journal of clinical and experimental medicine | 2,015 | |||
Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate. | Four groups of young adult male Brown-Norway rats (strain: BN/RijHsd) were either exposed whole-body (WB) to filtered air (negative control) or to respirable aerosols of monomeric diphenylmethane-4,4'-diisocyanate (MDI) at actual breathing zone concentrations of 9.2 +/- 1.5 and 118 +/- 8.6 mg/m3. One additional group w... | 10.1007/s002040100234 | 11,482,522 | D000336:Aerosols; D000818:Animals; D001831:Body Temperature; D001853:Bone Marrow; D004867:Equipment Design; D019570:Inhalation Exposure; D017953:Isocyanates; D008297:Male; D015162:Micronucleus Tests; D010316:Particle Size; D051381:Rats | Archives of toxicology | 2,001 | D000336:Aerosols; D017953:Isocyanates; C005969:4,4'-diphenylmethane diisocyanate |
Support for a radiation of free-living flatworms in the African Great Lakes region and the description of five new Macrostomum species. | BACKGROUND
The African Great Lakes have long been recognized as an excellent location to study speciation. Most famously, cichlid fishes have radiated in Lake Tanganyika and subsequently spread into Lake Malawi and Lake Victoria, where they again radiated. Other taxa have diversified in these lakes, such as catfish, os... | 10.1186/s12983-023-00509-9 | 37,670,326 | Frontiers in zoology | 2,023 | ||
Brain Activation of Elite Race Walkers in Action Observation, Motor Imagery, and Motor Execution Tasks: A Pilot Study. | Walking plays an important role in human daily life. Many previous studies suggested that long-term walking training can modulate brain functions. However, due to the use of measuring techniques such as fMRI and PET, which are highly motion-sensitive, it is difficult to record individual brain activities during the mov... | 10.3389/fnhum.2019.00080 | 30,881,297 | Frontiers in human neuroscience | 2,019 | ||
The oncogene eIF4E: using biochemical insights to target cancer. | The eukaryotic translation initiation factor eIF4E is overexpressed in many human malignancies where it is typically a harbinger of poor prognosis. eIF4E is positioned as a nexus in post-transcriptional gene expression. To carry out these functions, eIF4E needs to bind the m(7)G cap moiety on mRNAs. It plays critical r... | 10.1089/jir.2012.0142 | 23,472,659 | D000818:Animals; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D039561:Eukaryotic Initiation Factor-4E; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms; D009857:Oncogenes; D015398:Signal Transduction | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research | 2,013 | D039561:Eukaryotic Initiation Factor-4E |
In vitro antibacterial activity of ciprofloxacin loaded chitosan microparticles and their effects on human lung epithelial cells. | Chitosan (CS), due to its inherent mucoadhesive property and biofilm penetration ability, can be considered as very potent vehicle for local drug delivery to the lungs. This study reports on the preparation and in vitro antibacterial activity and cytotoxicity determination of ciprofloxacin loaded chitosan (Cipro-CS) mi... | 10.1016/j.ijpharm.2019.118578 | 31,362,096 | D000900:Anti-Bacterial Agents; D002460:Cell Line; D002470:Cell Survival; D048271:Chitosan; D002939:Ciprofloxacin; D065546:Drug Liberation; D004847:Epithelial Cells; D004926:Escherichia coli; D006801:Humans; D008168:Lung; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles; D011550:Pseudomonas aeruginosa; D013211... | International journal of pharmaceutics | 2,019 | D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D048271:Chitosan |
Quantification of postural sway patterns in tardive dyskinesia. | An assessment was made of the orientation and variability in postural center of pressure patterns in individuals with tardive dyskinesia (TD) and/or developmental disability during quiet standing. Postural patterns were compared and contrasted between four groups of individuals: those with (a) TD and developmentally di... | 10.1002/mds.870080309 | 8,101,968 | D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents; D003937:Diagnosis, Differential; D004409:Dyskinesia, Drug-Induced; D005260:Female; D006801:Humans; D008607:Intellectual Disability; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009069:Movement Disorders; D009460:Neurologic Examination; D0048... | Movement disorders : official journal of the Movement Disorder Society | 1,993 | D014150:Antipsychotic Agents |
Atrial fibrillation with a structurally normal heart in pregnancy: An international survey on current practice. | BACKGROUND
Little evidence exists for the optimal management of atrial fibrillation with a structurally normal heart in pregnancy.
METHODS
A survey was sent to members of two associations to obtain input on optimal management of atrial fibrillation in pregnancy. The survey presented four cases with respect to (1) bas... | 10.1177/1753495X16685684 | 28,680,466 | Obstetric medicine | 2,017 | ||
Detection of human papillomavirus DNA in benign oral squamous epithelial lesions in Venezuela. | The polymerase chain reaction (PCR) was applied to the detection of human papillomavirus (HPV) infection in biopsies taken from clinically normal oral mucosa of 20 subjects and clinical lesions of 40 patients. PCR for HPV-DNA amplification was performed using consensus primers MYO9/MYO11 and subsequent typing for HPV o... | 10.1034/j.1600-0714.2001.300701.x | 11,488,414 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003218:Condylomata Acuminata; D017931:DNA Primers; D004279:DNA, Viral; D005260:Female; D017573:Focal Epithelial Hyperplasia; D016679:Genome, Viral; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth ... | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology | 2,001 | D017931:DNA Primers; D004279:DNA, Viral |
Brownian motor with time-delayed feedback. | An inertial Brownian motor with time-delayed feedback driven by an unbiased time-periodic force is investigated. It is found that the mean velocity and the rectification efficiency are decreased when the noise intensity is increased. While the shape of the mean velocity and the rectification efficiency can be changed f... | 10.1103/PhysRevE.73.051107 | 16,802,918 | D001683:Biological Clocks; D003198:Computer Simulation; D004058:Diffusion; D004735:Energy Transfer; D005246:Feedback; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D020409:Molecular Motor Proteins; D010507:Periodicity; D013997:Time Factors | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,006 | D020409:Molecular Motor Proteins |
On the move. | Promotions / new appointments. | 10.7748/nm.12.7.6.s9 | 27,719,121 | Nursing management (Harrow, London, England : 1994) | 2,005 | ||
Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma. | NRF2 is a transcription factor that coordinates the antioxidant response in many different tissues, ensuring cytoprotection from endogenous and exogenous stress stimuli. In the kidney, its function is essential in appropriate cellular response to oxidative stress, however its aberrant activation supports progression, m... | 10.3390/cancers12113458 | 33,233,657 | Cancers | 2,020 | ||
Kyphoplasty Solves Stabilization and Pain Control Inadequately Treated via Prior Hartshill Rectangle for Thoracolumbar Burst Fracture. | Surgical management of spinal burst fractures has progressed to include minimally invasive techniques as preferred modalities of treatment. Burst fractures with indications for surgical treatment either through instability or intractable pain classically have required pedicle screw fixation, which requires extensive di... | 10.7759/cureus.18525 | 34,765,328 | Cureus | 2,021 | ||
[Beyond Coronary CT Angiography: CT Fractional Flow Reserve and Perfusion]. | Cardiac CT has been proven to provide diagnostic and prognostic evaluation of coronary artery disease for cardiovascular risk stratification and treatment decision-making based on rapid technological development and various research evidence. Coronary CT angiography has emerged as a gateway test for coronary artery dis... | 10.3348/jksr.2021.0177 | 36,237,355 | Taehan Yongsang Uihakhoe chi | 2,022 | ||
Association of Cardiovascular Health Score With Early- and Later-Onset Diabetes and With Subsequent Vascular Complications of Diabetes. | BACKGROUND Little attention has been paid to how well the American Heart Association's cardiovascular health (CVH) score predicts early-onset diabetes in young adults. We investigated the association of CVH score with early- and later-onset diabetes and with subsequent complications of diabetes. METHODS AND RESULTS Our... | 10.1161/JAHA.122.027558 | 36,565,184 | D055815:Young Adult; D006801:Humans; D014481:United States; D000328:Adult; D002318:Cardiovascular Diseases; D003929:Diabetic Neuropathies; D002319:Cardiovascular System; D003924:Diabetes Mellitus, Type 2; D001794:Blood Pressure; D005947:Glucose; D012307:Risk Factors | Journal of the American Heart Association | 2,023 | D005947:Glucose |
Treatment and Prevention of Pandemic H1N1 Influenza. | BACKGROUND
Swine influenza is a respiratory infection common to pigs worldwide caused by type A influenza viruses, principally subtypes H1N1, H1N2, H2N1, H3N1, H3N2, and H2N3. Swine influenza viruses also can cause moderate to severe illness in humans and affect persons of all age groups. People in close contact with s... | 27,036,721 | D000818:Animals; D000998:Antiviral Agents; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007252:Influenza Vaccines; D007251:Influenza, Human; D009976:Orthomyxoviridae Infections; D058873:Pandemics; D060888:Real-Time Polymerase Chain Reaction; D013552:Swine; D013553:Swine Diseases | Annals of global health | 2,015 | D000998:Antiviral Agents; D007252:Influenza Vaccines | |
The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat. | Carrageenan was subcutaneously injected in the area innervated by the saphenous nerve. Part of the mechano-heat sensitive C-fiber receptors (CHM) located inside or at the border of the inflamed area showed an enhanced responsiveness to heat stimulation (sensitization). Those CMH units exhibited spontaneous activity; th... | 10.1016/0304-3959(87)90051-0 | 3,614,971 | D000818:Animals; D002351:Carrageenan; D004487:Edema; D006358:Hot Temperature; D007249:Inflammation; D008297:Male; D009412:Nerve Fibers; D009619:Nociceptors; D010146:Pain; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds; D012867:Skin | Pain | 1,987 | D002351:Carrageenan |
Image-based spatio-temporal model of drug delivery in a heterogeneous vasculature of a solid tumor - Computational approach. | The solute transport distribution in a tumor is an important criterion in the evaluation of the cancer treatment efficacy. The fraction of killed cells after each treatment can quantify the therapeutic effect and plays as a helpful tool to evaluate the chemotherapy treatment schedules. In the present study, an image-ba... | 10.1016/j.mvr.2019.01.005 | 30,711,547 | D000970:Antineoplastic Agents; D001692:Biological Transport; D002470:Cell Survival; D004058:Diffusion; D004317:Doxorubicin; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008833:Microcirculation; D008954:Models, Biological; D009369:Neoplasms; D009389:Neovascularization, Pathologic; D009716:Numerical ... | Microvascular research | 2,019 | D000970:Antineoplastic Agents; D004317:Doxorubicin |
CYP1A1 gene polymorphisms and polycystic ovary syndrome risk: a meta-analysis and meta-regression. | AIMS
Emerging evidence suggests that common functional polymorphisms in the CYP1A1 gene are involved in the regulation of the activities of cytochrome P450 enzymes, thereby increasing an individual's susceptibility to polycystic ovary syndrome (PCOS), but individually published results are inconclusive. This meta-analy... | 10.1089/gtmb.2013.0209 | 23,848,208 | D000483:Alleles; D019363:Cytochrome P-450 CYP1A1; D005260:Female; D006801:Humans; D007194:India; D008957:Models, Genetic; D011085:Polycystic Ovary Syndrome; D011110:Polymorphism, Genetic; D039781:PubMed; D012307:Risk Factors; D014421:Turkey | Genetic testing and molecular biomarkers | 2,013 | C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1 |
Application of a probabilistic double-fibre structure model to diffusion-weighted MR images of the human brain. | A Markov chain Monte Carlo (MCMC) algorithm has been reported which is capable of determining the probabilistic orientation of two-fibre populations from high angular resolution diffusion-weighted data (HARDI). We present and critically discuss the application of this algorithm to in vivo human datasets acquired in cli... | 10.1016/j.mri.2007.07.002 | 17,881,178 | D000465:Algorithms; D016880:Anisotropy; D001499:Bayes Theorem; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008390:Markov Chains; D009010:Monte Carlo Method; D009413:Nerve Fibers, Myelinated; D011336:Probability | Magnetic resonance imaging | 2,008 | |
Nutrition and physical activity level of adolescents with idiopathic scoliosis: a narrative review. | Some studies have shown that patients with adolescent idiopathic scoliosis (AIS) have different anthropometric features compared with their peers such as taller stature, lower body mass index, and bone mineral density. Yet the causes explaining these differences remain uncertain. Nutritional intake and status, combined... | 10.1016/j.spinee.2019.11.012 | 31,783,126 | D000293:Adolescent; D015992:Body Mass Index; D015519:Bone Density; D015444:Exercise; D006801:Humans; D009752:Nutritional Status; D012600:Scoliosis | The spine journal : official journal of the North American Spine Society | 2,020 | |
Efficient full-path optical calculation of scalar and vector diffraction using the Bluestein method. | Efficient calculation of the light diffraction in free space is of great significance for tracing electromagnetic field propagation and predicting the performance of optical systems such as microscopy, photolithography, and manipulation. However, existing calculation methods suffer from low computational efficiency and... | 10.1038/s41377-020-00362-z | 32,695,316 | Light, science & applications | 2,020 | ||
Hip problems in cerebral palsy: screening, diagnosis and treatment. | PURPOSE OF REVIEW
Spastic type is the most common form of cerebral palsy. The purpose of this review was to evaluate recent literature for current trends in the surveillance and treatment of spastic hip problems in cerebral palsy.
RECENT FINDINGS
Cerebral palsy is still the most common physical disability in childhoo... | 10.1097/MOP.0000000000000040 | 24,299,910 | D000465:Algorithms; D002547:Cerebral Palsy; D002648:Child; D005684:Gait; D006617:Hip Dislocation; D006801:Humans; D008403:Mass Screening; D018482:Muscle, Skeletal; D010027:Osteotomy | Current opinion in pediatrics | 2,014 | |
Hip replacement for adults with unreduced congenital dislocation. A new surgical technique. | Total hip replacement for adults with unreduced congenital dislocation presents a difficult problem because soft-tissue contractures usually prevent sitting at the normal anatomical level. Extensive soft-tissue division or a high-level acetabulum leads to reduced function and poor fixation of the components. We describ... | 10.1302/0301-620X.69B5.3316239 | 3,316,239 | D000077:Acetabulum; D016025:Bone Transplantation; D005260:Female; D005270:Femur Head; D006618:Hip Dislocation, Congenital; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D009132:Muscles; D011474:Prosthesis Design | The Journal of bone and joint surgery. British volume | 1,987 | |
Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis. | Protein phosphatase 2A (PP2A) is a critical serine/threonine phosphatase involved in the control of multiple cellular functions. Distinct regulatory subunits of this holoenzyme govern its intracellular localisation and substrate specificity. The regulatory B subunits target PP2A to the substrate. The B56delta subunit e... | 10.1159/000076823 | 15,051,958 | D000818:Animals; D002352:Carrier Proteins; D015870:Gene Expression; D008297:Male; D051379:Mice; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2; D021122:Protein Subunits; D012689:Sequence Homology, Nucleic Acid; D013091:Spermatogenesis; D013094:Spermatozoa; D013737:Testis | Cytogenetic and genome research | 2,003 | D002352:Carrier Proteins; D021122:Protein Subunits; D010749:Phosphoprotein Phosphatases; C485589:Ppp2r5c protein, mouse; C475028:Ppp2r5d protein, mouse; D054648:Protein Phosphatase 2 |
The effect of coadministration of α-tocopherol and ascorbic acid on arsenic trioxide-induced testicular toxicity in adult rats. | BACKGROUND
Arsenic, acting as an endocrine disruptor, causes reproductive malfunctions. Studies have been undertaken to find out whether the co-supplementation of α-tocopherol and ascorbic acid (AT-AA) could reduce the arsenic-induced testicular toxicity caused by oxidative stress and resulting DNA damage.
METHODS
Ad... | 23,950,573 | D000818:Animals; D000975:Antioxidants; D000077237:Arsenic Trioxide; D001152:Arsenicals; D001205:Ascorbic Acid; D004249:DNA Damage; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D052244:Endocrine Disruptors; D008297:Male; D018384:Oxidative Stress; D010087:Oxides; D051381:Rats; D017208:Rats, Wistar; D013091:... | Journal of basic and clinical physiology and pharmacology | 2,013 | D000975:Antioxidants; D001152:Arsenicals; D052244:Endocrine Disruptors; D010087:Oxides; D013739:Testosterone; D024502:alpha-Tocopherol; D001205:Ascorbic Acid; D000077237:Arsenic Trioxide | |
Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388. | PURPOSE
The beta-adrenoceptor (beta-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac beta-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows it... | 10.1007/s00259-004-1701-z | 15,592,928 | D000328:Adult; D000368:Aged; D001562:Benzimidazoles; D002250:Carbon Radioisotopes; D002311:Cardiomyopathy, Dilated; D015536:Down-Regulation; D005260:Female; D006321:Heart; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D009206:Myocardium; D049268:Positron-Emission Tomography; D019275:Radiopharmaceu... | European journal of nuclear medicine and molecular imaging | 2,005 | D001562:Benzimidazoles; D002250:Carbon Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals; D011943:Receptors, Adrenergic, beta; C109239:CGP 12388 |
State of the art in sheep-goat embryo transfer. | Considerable advances have been made in the last 25 yr in sheep and goat embryo production and transfer technology. This presentation covers the procedures used to overcome the variability of ovarian response after treatment with exogeneous gonadotropins, the asynchrony of ovulations, failure of fertilization in female... | 10.1016/s0093-691x(98)00235-0 | 10,729,066 | D000818:Animals; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006041:Goats; D012756:Sheep; D013480:Superovulation | Theriogenology | 1,999 | |
Advances in head and neck imaging. | Imaging plays a key role in dental implantation, management of maxillofacial trauma, facial reconstruction, temporomandibular joint pathology, and evaluation and treatment of neoplasms and infections. In addition to traditional conventional radiography, recent advances in computer tomography, magnetic resonance imaging... | 10.1016/j.coms.2009.10.002 | 20,159,481 | D001847:Bone Diseases; D003757:Dental Implantation; D003952:Diagnostic Imaging; D005147:Facial Bones; D006257:Head; D006258:Head and Neck Neoplasms; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008446:Maxillofacial Injuries; D009333:Neck; D049268:Positron-Emission To... | Oral and maxillofacial surgery clinics of North America | 2,010 | D019275:Radiopharmaceuticals |
Circulating level of fatty acid-binding protein 4 is an independent predictor of metabolic dysfunction-associated fatty liver disease in middle-aged and elderly individuals. | AIMS/INTRODUCTION
Metabolic dysfunction-associated fatty liver disease (MAFLD), defined as hepatosteatosis with type 2 diabetes mellitus, overweight/obesity or metabolic dysregulation, has been proposed as a new feature of chronic liver disease. Fatty acid-binding protein 4 (FABP4) is expressed in adipose tissue, and s... | 10.1111/jdi.13735 | 34,889,064 | D052242:Adiponectin; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D008076:Cholesterol, HDL; D003924:Diabetes Mellitus, Type 2; D050556:Fatty Acid-Binding Proteins; D005234:Fatty Liver; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D014527:Uric Acid; D055815:Yo... | Journal of diabetes investigation | 2,022 | D052242:Adiponectin; D008076:Cholesterol, HDL; D050556:Fatty Acid-Binding Proteins; D014527:Uric Acid |
Health impairments among refuse derived fuel workers. | We conducted this study to address concerns regarding a perceived increase in bronchitis, skin rashes, and diarrhea and long term health effects in workers at two Refuse Derived Fuel (RDF) processing plants. We abstracted medical records to assess symptom occurrence, and to identify spirometry and lab abnormalities. Ov... | 9,501,632 | D000328:Adult; D009783:Dermatitis, Occupational; D004736:Energy-Generating Resources; D005260:Female; D006801:Humans; D008297:Male; D009784:Occupational Diseases; D012037:Refuse Disposal; D012140:Respiratory Tract Diseases | Arhiv za higijenu rada i toksikologiju | 1,997 | ||
Coronary spasm reflects inputs from adjacent esophageal system. | Mechanisms underlying coronary spasm are still poorly understood. The aim of the study was to assess the hypothesis that fluctuations in the development of coronary spasm might reflect inputs from the adjacent esophageal system. We enrolled patients admitted to the coronary care unit for episodes of nocturnal angina. S... | 10.1152/ajpheart.00925.2005 | 16,387,792 | D000328:Adult; D000789:Angina, Unstable; D001341:Autonomic Nervous System; D003324:Coronary Artery Disease; D015155:Esophageal Spasm, Diffuse; D004947:Esophagus; D005260:Female; D006321:Heart; D006801:Humans; D008297:Male; D013577:Syndrome | American journal of physiology. Heart and circulatory physiology | 2,006 | |
Fentanyl inhibits GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. | Fentanyl citrate is a synthetic opiate analgesic often used clinically for neonatal anesthesia. Although fentanyl significantly depresses heart rate, the mechanism of inducing bradycardia remains unclear. One possible site of action is the cardioinhibitory parasympathetic vagal neurons in the nucleus ambiguus (NA), fro... | 10.1016/j.brainres.2004.02.010 | 15,064,141 | D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000779:Anesthetics, Local; D000818:Animals; D000831:Animals, Newborn; D004347:Drug Interactions; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D005283:Fentanyl; D018684:Glycine Agents; D006321:Heart; D066298:In Vitro Techniques; D008526... | Brain research | 2,004 | D000779:Anesthetics, Local; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D018684:Glycine Agents; D009294:Narcotics; C049352:phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide; D013779:Tetrodotoxin; D013004:Somatostatin; D005680:gamma-Aminob... |
Giant cell arteritis in a patient with acute aortic insufficiency with thyrotoxicosis. | Acute aortic insufficiency in the setting of thyrotoxicosis can mask the presentation of vasculitis. We report a case of a 38-year-old woman with a 22 weeks gestation pregnancy who was known to be hyperthyroid for 4 months prior to conception. She presented with thyrotoxicosis and acute respiratory failure. Echocardiog... | 10.1007/s10067-004-1073-6 | 15,902,527 | D000328:Adult; D001022:Aortic Valve Insufficiency; D005260:Female; D013700:Giant Cell Arteritis; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D012131:Respiratory Insufficiency; D013971:Thyrotoxicosis | Clinical rheumatology | 2,006 | |
Cost-effectiveness of human papillomavirus vaccine in China: a systematic review of modelling studies. | OBJECTIVES
China suffers from high burdens of human papillomavirus (HPV) and cervical cancer, whereas the uptake of HPV vaccine remains low. The first Chinese domestic HPV vaccine was released in 2019. However, collective evidence on cost-effectiveness of HPV vaccination in China has yet to be established. We summarise... | 10.1136/bmjopen-2021-052682 | 34,880,019 | D003362:Cost-Benefit Analysis; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections; D053918:Papillomavirus Vaccines; D002583:Uterine Cervical Neoplasms; D014611:Vaccination | BMJ open | 2,021 | D053918:Papillomavirus Vaccines |
Chronic Cortical Cerebral Microinfarcts Slow Down Cognitive Recovery After Acute Ischemic Stroke. | Background and Purpose- Cortical cerebral microinfarcts (CMIs) have been associated with vascular dementia and Alzheimer disease. The aim of the present study was to evaluate the role of cortical CMI detected on 3T magnetic resonance imaging, on the evolution of cognition during the year following an acute ischemic str... | 10.1161/STROKEAHA.118.024672 | 31,084,336 | D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease; D002540:Cerebral Cortex; D002544:Cerebral Infarction; D002908:Chronic Disease; D003071:Cognition; D015140:Dementia, Vascular; D006801:Humans; D006973:Hypertension; D008279:Magnetic Resonance Imaging; D000073216:Mental Status and Dementia Tests; D008875... | Stroke | 2,019 | |
On the interplay between electromigration and electroosmosis during electrokinetic transport in heterogeneous porous media. | Electrokinetic techniques represent a valuable approach to enhance solute transport, reactant delivery and contaminant degradation in complex environmental matrices, such as contaminated soil and groundwater, and have a great potential for the remediation of many organic and inorganic pollutants. This study investigate... | 10.1016/j.watres.2022.118161 | 35,152,137 | Water research | 2,022 | ||
Genome Sequence of the Pathogenic Bacterium Vibrio vulnificus Biotype 3. | We report the first genome sequence of the pathogenic Vibrio vulnificus biotype 3. This draft genome sequence of the environmental strain VVyb1(BT3), isolated in Israel, provides a representation of this newly emerged clonal group, which reveals higher similarity to the clinical strains of biotype 1 than to the environ... | 23,599,289 | Genome announcements | 2,013 | |||
Competing risk model for prognostic comparison between clear cell type and common type hepatocellular carcinoma: A population-based propensity score matching study. | BACKGROUND
Clear cell type hepatocellular carcinoma (HCC) is an uncommon neoplasm with an ambivalent prognosis compared to common type HCC.
METHODS
First, patients with clear cell or common type HCC were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database, and their demographic and clinical ... | 10.1002/cam4.5773 | 36,934,433 | D006801:Humans; D005260:Female; D008297:Male; D006528:Carcinoma, Hepatocellular; D011379:Prognosis; D008113:Liver Neoplasms; D057216:Propensity Score; D012189:Retrospective Studies | Cancer medicine | 2,023 | |
Attitudes and feelings towards menstruation and womanhood in girls at menarche. | AIM
To elucidate early adolescent girls' attitudes, thoughts and feelings towards menstruation and their bodies.
METHODS
309 12-y-old girls answered questionnaires. One part of the questionnaire dealt with thoughts and feelings towards menstruation. The other part dealt with thoughts and feelings towards menstruation... | 10.1080/08035250500531697 | 16,754,552 | D001290:Attitude; D002648:Child; D004644:Emotions; D005260:Female; D006801:Humans; D008598:Menstruation; D011795:Surveys and Questionnaires | Acta paediatrica (Oslo, Norway : 1992) | 2,006 | |
Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. | BACKGROUND
As a marker of genetic susceptibility and shared lifestyle characteristics, family history of cancer is often used to evaluate an individual's risk for developing a particular malignancy. With comprehensive data on pigment characteristics, lifestyle factors, and melanocortin 1 receptor (MC1R) gene sequence, ... | 26,381,319 | D000328:Adult; D000368:Aged; D002280:Carcinoma, Basal Cell; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D044102:Receptor, Melanocortin, Type 1; D012307:Risk Factors; D012878:Skin Neoplasms | Cancer epidemiology | 2,015 | D044102:Receptor, Melanocortin, Type 1 | |
MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors. | OBJECTIVE
To study the function of miR-145, known to be dysregulated in endometriosis, and to identify its target genes in an in vitro endometriosis model.
DESIGN
Experimental laboratory study.
SETTING
University medical centers.
PATIENT(S)
Primary endometrial stroma cells were derived from eutopic endometrium of... | 23,312,222 | D000328:Adult; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D002460:Cell Line; D049109:Cell Proliferation; D003599:Cytoskeleton; D004715:Endometriosis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D000090062:Kruppel-Like Factor 4; D035683:MicroRNAs; D008840:Microfilament Proteins; D010641:... | Fertility and sterility | 2,013 | D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; C407243:F11R protein, human; C502658:FSCN1 protein, human; C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; C541010:MIRN145 microRNA, human; C438151:MSI2 protein, human; D035683:MicroRNAs; D008840:Microfilament Proteins; D017395:Plasminogen Act... | |
The maturation state of three types of granulocyte/macrophage progenitor cells from mouse bone marrow. | The progenitor cells of neutrophil granulocytes and macrophages which are able to proliferate and differentiate in vitro (CFU-c) form a heterogeneous population. By the use of specific colony stimulating activities and cell separation by equilibrium density centrifugation, three subpopulations of CFU-c can be detected.... | 10.1002/jcp.1041020215 | 6,966,285 | D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D002999:Clone Cells; D003115:Colony-Stimulating Factors; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D007700:Kinetics; D008264:Macrophages; D051379:Mice; D009504:Neutrophils | Journal of cellular physiology | 1,980 | D003115:Colony-Stimulating Factors |
In silico study directed towards identification of novel high-affinity inhibitors targeting an oncogenic protein: BRD4-BD1. | Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) family of proteins. It epigentically regulates the transcription of growth-promoting genes and has become an attractive target for the development of anticancer and anti-inflammatory agents. In the current study, we p... | 10.1080/1062936X.2018.1537301 | 30,411,639 | D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D001665:Binding Sites; D018797:Cell Cycle Proteins; D003198:Computer Simulation; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D062105:Molecular Docking Simulation; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure... | SAR and QSAR in environmental research | 2,018 | D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; C441289:BRD4 protein, human; D018797:Cell Cycle Proteins; D008024:Ligands; D009687:Nuclear Proteins; D014157:Transcription Factors; D014867:Water |
Characteristics and prevalence within serogroup O4 of a J96-like clonal group of uropathogenic Escherichia coli O4:H5 containing the class I and class III alleles of papG. | The recent discovery of a geographically dispersed clonal group of Escherichia coli O4:H5 that includes prototypic uropathogenic strain J96 prompted us to determine the prevalence of J96-like strains within serogroup O4 and to further assess the characteristics of such strains. We used O:K:H;F serotyping, PCR-based gen... | 10.1128/iai.65.6.2153-2159.1997 | 9,169,745 | D018830:Adhesins, Escherichia coli; D000483:Alleles; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli; D036781:Fimbriae Proteins; D006801:Humans; D012703:Serotyping; D014552:Urinary Tract Infections | Infection and immunity | 1,997 | D018830:Adhesins, Escherichia coli; C092426:PapG protein, E coli; D036781:Fimbriae Proteins |
Transient Chimeric Ad5/37 Fiber Enhances NK-92 Carrier Cell-Mediated Delivery of Oncolytic Adenovirus Type 5 to Tumor Cells. | Methods for customizing and improving virus vector tropism are limited. In this study, we introduce a microRNA (miRNA)-regulated molecular method to enhance vector transduction without genome alteration. Based on the importance of adenovirus (Ad) vectors for cancer and gene treatment, we exemplified this technology for... | 10.1016/j.omtm.2020.06.010 | 32,695,840 | Molecular therapy. Methods & clinical development | 2,020 | ||
A DGT technique for plutonium bioavailability measurements. | The toxicity of heavy metals in natural waters is strongly dependent on the local chemical environment. Assessing the bioavailability of radionuclides predicts the toxic effects to aquatic biota. The technique of diffusive gradients in thin films (DGT) is largely exploited for bioavailability measurements of trace meta... | 10.1021/es501149v | 25,141,175 | D000180:Acrylic Resins; D001682:Biological Availability; D004058:Diffusion; D004784:Environmental Monitoring; D011005:Plutonium | Environmental science & technology | 2,014 | D000180:Acrylic Resins; D011005:Plutonium; C016679:polyacrylamide |
Prenatal diagnosis and management of congenital heart defect: significance of associated fetal anomalies and prenatal chromosome studies. | A fetal cardiac defect was found prenatally by ultrasound in 13 of 230 women (5.6%) with a suspected fetal anomaly. Pregnancy duration varied between 17 and 39 weeks (mean 28 weeks). The reasons for referral of the 13 patients were: suspected fetal structural defect (n = 4), oligo- or polyhydramnios (n = 2), severe fet... | 10.1002/ajmg.1320210210 | 3,893,127 | D000649:Amniocentesis; D000653:Amniotic Fluid; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D000013:Congenital Abnormalities; D005260:Female; D006330:Heart Defects, Congenital; D006801:Humans; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography | American journal of medical genetics | 1,985 | |
Detailed Characterization of the Surface and Growth Mechanism of Monodisperse Ni3Sn4 Nanoparticles. | Synthesis of most tin-based bimetallic nanoparticles is a challenging task because of the differences in the redox potential and the melting point between both components. This article presents a co-reduction synthesis of monoclinic Ni3Sn4 nanoparticles. Varying time and temperature gives the possibility to control the... | 10.1021/acsomega.8b02597 | 31,458,316 | ACS omega | 2,018 | ||
Using the Americans with Disabilities Act to the advantage of persons with severe and persistent mental illness: what rehabilitation counselors need to know. | This article explains central constructs and definitions underlying the Americans with Disabilities Act (ADA) and discusses their implications for persons with severe and persistent mental illness, as well as for rehabilitation counselors working with this population. Focus is placed upon Title I of the ADA, which proh... | 12,897,391 | D004651:Employment; D006801:Humans; D019989:Persons with Mental Disabilities; D012050:Rehabilitation, Vocational; D014481:United States; D014830:Vocational Guidance | Work (Reading, Mass.) | 2,003 | ||
The effects of environmental aryl hydrocarbon receptor ligands on signaling and cell metabolism in cancer. | Dioxin and dioxin-like compounds are chlorinated organic pollutants formed during the manufacturing of other chemicals. Dioxins are ligands of the aryl hydrocarbon receptor (AHR), that induce AHR-mediated biochemical and toxic responses and are persistent in the environment. 2,3,7,8- tetrachlorodibenzo para dioxin (TCD... | 10.1016/j.bcp.2023.115771 | 37,652,105 | D006801:Humans; D004147:Dioxins; D008024:Ligands; D009369:Neoplasms; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon | Biochemical pharmacology | 2,023 | D004147:Dioxins; D008024:Ligands; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon |
Salidroside induces apoptosis in human ovarian cancer SKOV3 and A2780 cells through the p53 signaling pathway. | Salidroside is one of the most potent compounds extracted from the plant Rhodiola rosea, and its cardiovascular protective effects have been studied extensively. However, the role of salidroside in human ovarian carcinoma remains unknown. The aim of the current study was to investigate the effects of salidroside on the... | 10.3892/ol.2018.8090 | 29,616,120 | Oncology letters | 2,018 | ||
Transplantation of fecal microbiota from patients with inflammatory bowel disease and depression alters immune response and behavior in recipient mice. | Gut dysbiosis is closely associated with the occurrence of inflammatory bowel disease (IBD) and psychiatric disorder. Here, to understand the difference of gut microbiota composition and physiological effect between IBD patients with (IBD/D+) or without depression (IBD/D-), we analyzed the fecal microbiota composition ... | 10.1038/s41598-021-00088-x | 34,650,107 | D000328:Adult; D000818:Animals; D001007:Anxiety; D003092:Colitis; D003106:Colon; D003345:Corticosterone; D003863:Depression; D000069467:Fecal Microbiota Transplantation; D000069196:Gastrointestinal Microbiome; D006624:Hippocampus; D006801:Humans; D007109:Immunity; D015212:Inflammatory Bowel Diseases; D015850:Interleuki... | Scientific reports | 2,021 | D015850:Interleukin-6; D009195:Peroxidase; D003345:Corticosterone |
Chronic pure red cell aplasia caused by parvovirus B19 in AIDS: use of intravenous immunoglobulin--a report of eight patients. | The optimal management of chronic pure red cell aplasia caused by parvovirus B19 (B19-PRCA) in patients with AIDS is unclear. Our purpose was to determine the effects of intravenous immunoglobulin (IVIg) in the treatment of B19-PRCA in patients with AIDS. The patients were eight adults with AIDS admitted during the per... | 10.1002/(sici)1096-8652(199905)61:1<16::aid-ajh4>3.0.co;2-y | 10,331,506 | D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D001706:Biopsy; D001853:Bone Marrow; D004279:DNA, Viral; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous; D008297:Male; D010322:Parvoviridae Infections; D016732:Parvovirus B19, Human; D011446:Prospective Studies; D012008:Recurrence; D012010... | American journal of hematology | 1,999 | D004279:DNA, Viral; D016756:Immunoglobulins, Intravenous |
Cervico-isthmic pregnancy: an extremely rare case diagnosed during labour. | This case report describes a cervico-isthmic pregnancy ending in a live vaginal birth at 37+2 weeks' gestation. The case remained undiagnosed throughout pregnancy when after a fairly normal labour a massive haemorrhage occurred. After an unsuccessful effort to control the bleeding conservatively, a total abdominal hyst... | 10.1016/s0301-2115(01)00325-6 | 11,574,142 | D002584:Cervix Uteri; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008297:Male; D007744:Obstetric Labor Complications; D011247:Pregnancy; D011271:Pregnancy, Ectopic; D016896:Treatment Outcome; D014592:Uterine Hemorrhage; D014599:Uterus | European journal of obstetrics, gynecology, and reproductive biology | 2,001 | |
[Vascularized illiac bone grafts and reconstruction of the mandible]. | OBJECTIVE
To investigate method of reconstructing large mandible defects.
METHODS
Seven cases of mandibular defects were reconstructed with vascularied illiac bone grafts supplied by circumflex illiac vessels and Bränemark osseointegration implants immediately.
RESULTS
Six months after operation, X-rays showed osse... | 11,776,928 | D000293:Adolescent; D000328:Adult; D016025:Bone Transplantation; D015921:Dental Implants; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible; D016348:Osseointegration; D019651:Plastic Surgery Procedures; D016896:Treatment Outcome | Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology | 1,999 | D015921:Dental Implants |
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