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Issues concerning scientific production of including people with disabilities at work. | This article presents the results of a survey carried out on leading periodicals in the areas of Ergonomics, Physiotherapy and Occupational Therapy, the aim of which was to identify scientific publications on the inclusion at work of people with disabilities. The survey of articles published on this topic in the follow... | 10.3233/WOR-2012-0024-4722 | 22,317,448 | D015706:Bibliometrics; D006233:Disabled Persons; D004651:Employment; D006804:Ergonomics; D006801:Humans; D009788:Occupational Therapy; D026741:Physical Therapy Modalities; D011643:Publishing | Work (Reading, Mass.) | 2,012 | |
The role of federally funded health centers in serving the rural population. | CONTEXT
Federally funded health centers attempt to improve rural health by reducing and eliminating access barriers to primary care services.
PURPOSE
This study compares rural health center patients with people in the general rural population for indicators of access to preventive services and health outcomes.
METH... | 10.1111/j.1748-0361.2003.tb00552.x | 12,696,847 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D002648:Child; D002675:Child, Preschool; D003151:Community Health Centers; D003710:Demography; D035082:Federal Government; D005260:Female; D005380:Financing, Government; D006297:Health Services Accessibility; D006302:Health Services Research; D0... | The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association | 2,003 | |
Impulsive and premeditated subtypes of aggression in conduct disorder: differences in time estimation. | Research aimed at identifying and studying subtypes of aggression have historically dichotomized aggressive subtypes, although specific nomenclature has varied; one approach has been to classify aggressive behavior as predominantly impulsive or predominantly premeditated. There are a number of behavioral and cognitive ... | 10.1002/ab.20219 | 17,654,672 | D000293:Adolescent; D000374:Aggression; D003072:Cognition Disorders; D019955:Conduct Disorder; D007174:Disruptive, Impulse Control, and Conduct Disorders; D005260:Female; D006801:Humans; D008297:Male; D011594:Psychometrics; D013998:Time Perception; D014888:Wechsler Scales | Aggressive behavior | 2,007 | |
Contrast sensitivity versus static visual field testing during experimental elevation of intraocular pressure. | Contrast sensitivity testing has been recommended as a more sensitive indicator of early visual loss than visual field testing. Using gravity inversion to induce an intraocular pressure rise, we performed contrast sensitivity testing on each eye of 10 normal subjects in the upright and inverted positions. Contrast sens... | 10.1007/BF02169410 | 2,777,103 | D000328:Adult; D015350:Contrast Sensitivity; D006801:Humans; D007429:Intraocular Pressure; D011187:Posture; D058609:Visual Field Tests; D014794:Visual Fields | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie | 1,989 | |
The dinoflagellate Lingulodinium polyedrum responds to N depletion by a polarized deposition of starch and lipid bodies. | Dinoflagellates are important contributors to the marine phytoplankton and global carbon fixation, but are also infamous for their ability to form the spectacular harmful algal blooms called red tides. While blooms are often associated with high available nitrogen, there are instances where they are observed in oligotr... | 10.1371/journal.pone.0111067 | 25,368,991 | D016764:Cell Polarity; D002736:Chloroplasts; D004141:Dinoflagellida; D008055:Lipids; D008856:Microscopy, Fluorescence; D009584:Nitrogen; D010078:Oxazines; D010788:Photosynthesis; D013053:Spectrophotometry; D013213:Starch | PloS one | 2,014 | D008055:Lipids; D010078:Oxazines; D013213:Starch; D009584:Nitrogen; C044808:nile red |
[Screening of blood donors for the prevention of post-transfusion hepatitis by means of gamma-glutamyl transpeptidase determination]. | The authors describe the application for determining gamma-glutamyl-transpeptidase (GGTP) activity in donors in order to prevent posttransfusion hepatitis. They particularly refer to the high susceptibility of this method for detecting latent and chronic liver diseases virtually unable to be recognized by other methods... | 83,278 | D006505:Hepatitis; D006511:Hepatitis B Antigens; D006801:Humans; D065227:Transfusion Reaction; D005723:gamma-Glutamyltransferase | Folia haematologica (Leipzig, Germany : 1928) | 1,978 | D006511:Hepatitis B Antigens; D005723:gamma-Glutamyltransferase | |
PIF4 Integrates Multiple Environmental and Hormonal Signals for Plant Growth Regulation in Arabidopsis. | As sessile organisms, plants must be able to adapt to the environment. Plants respond to the environment by adjusting their growth and development, which is mediated by sophisticated signaling networks that integrate multiple environmental and endogenous signals. Recently, increasing evidence has shown that a bHLH tran... | 10.14348/molcells.2016.0126 | 27,432,188 | D017360:Arabidopsis; D029681:Arabidopsis Proteins; D051792:Basic Helix-Loop-Helix Transcription Factors; D048708:Cell Growth Processes; D057906:Circadian Clocks; D004781:Environmental Exposure; D018506:Gene Expression Regulation, Plant; D053263:Gene Regulatory Networks; D063245:Plant Development; D010937:Plant Growth R... | Molecules and cells | 2,016 | D029681:Arabidopsis Proteins; D051792:Basic Helix-Loop-Helix Transcription Factors; C459466:PIF4 protein, Arabidopsis; D010937:Plant Growth Regulators |
Differences in basal and stress-induced HPA regulation of wild house mice selected for high and low aggression. | Male wild house mice, selected for short (SAL) and long (LAL) attack latency, show distinctly different behavioral strategies in coping with environmental challenges. In this study, we tested the hypothesis that this difference in coping style is associated with a differential stress responsiveness of the hypothalamic-... | 10.1016/s0018-506x(02)00013-2 | 12,614,650 | D000208:Acute Disease; D000324:Adrenocorticotropic Hormone; D000374:Aggression; D000818:Animals; D000835:Animals, Wild; D001522:Behavior, Animal; D001835:Body Weight; D001947:Breeding; D003345:Corticosterone; D003346:Corticotropin-Releasing Hormone; D015870:Gene Expression; D007030:Hypothalamo-Hypophyseal System; D0513... | Hormones and behavior | 2,003 | D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone |
Increasing general practitioner use of evidence-based medicine in teaching and clinical practice through evidence-based journal clubs. | Learning evidence-based medicine (EBM) skills is now integral to university medical education. GPs who trained before the introduction of EBM in the late 1990s have identified a lack of training in this area. Evidence-based journal clubs (EBJCs) aim to promote the application of research evidence to clinical decision m... | 10.1071/PY20267 | 34,233,147 | D000066491:Clinical Decision-Making; D019317:Evidence-Based Medicine; D058005:General Practitioners; D006801:Humans; D007858:Learning; D013337:Students, Medical | Australian journal of primary health | 2,021 | |
Vitamin D status and its relationship with parathyroid hormone and bone mineral status in older adolescents. | Osteoporosis is an important contributor to the global burden of disease, and in the UK alone results in one in three women and one in twelve men aged >50 years experiencing a fragility fracture. Optimising peak bone mass in early adulthood is thought to reduce osteoporosis risk by offsetting bone losses in later life.... | 10.1079/pns2005420 | 15,960,864 | D000293:Adolescent; D015519:Bone Density; D001842:Bone and Bones; D006801:Humans; D009751:Nutritional Requirements; D009752:Nutritional Status; D010024:Osteoporosis; D010281:Parathyroid Hormone; D014807:Vitamin D | The Proceedings of the Nutrition Society | 2,005 | D010281:Parathyroid Hormone; D014807:Vitamin D |
Specific versus non-specific actions of opioids on hippocampal neurones in the rat brain. | An investigation has been made into the pharmacological specificity of the actions of microelectrophoretically applied opioids on neurones in the rat hippocampus, a structure containing a low concentration of specific receptors for these substances. The majority of hippocampal neurones remained unaffected by morphine o... | 10.1016/0006-8993(79)90357-3 | 218,682 | D000200:Action Potentials; D000818:Animals; D003917:Dextrorphan; D004361:Drug Tolerance; D004723:Endorphins; D004745:Enkephalins; D005071:Evoked Potentials; D005971:Glutamates; D006624:Hippocampus; D007981:Levorphanol; D008297:Male; D009020:Morphine; D009270:Naloxone; D009433:Neural Inhibition; D009474:Neurons; D051381... | Brain research | 1,979 | D004723:Endorphins; D004745:Enkephalins; D005971:Glutamates; D011957:Receptors, Opioid; D003917:Dextrorphan; D007981:Levorphanol; D009270:Naloxone; D009020:Morphine |
Plasmid transformation of naturally competent Acinetobacter calcoaceticus in non-sterile soil extract and groundwater. | The natural transformation of Acinetobacter calcoaceticus BD413 (trpE27) was characterized with respect to features that might be important for a possible gene transfer by extracellular DNA in natural environments. Transformation of competent cells with chromosomal DNA (marker trp+) occurred in aqueous solutions of sin... | 10.1007/BF00248681 | 1,590,708 | D016954:Acinetobacter calcoaceticus; D002118:Calcium; D008274:Magnesium; D008345:Manganese; D010957:Plasmids; D012988:Soil Microbiology; D014169:Transformation, Bacterial; D014871:Water Microbiology | Archives of microbiology | 1,992 | D008345:Manganese; D008274:Magnesium; D002118:Calcium |
Organelle transport along microtubules - the role of KIFs. | Organelle transporters are very important for cellular morphogenesis and other cellular functions, conveying and targeting important materials to the correct destination, often at considerable velocities. One of the first proteins to be identified as a motor was kinesin, and recently at least 10 new kinesin superfamily... | 10.1016/0962-8924(96)10003-9 | 15,157,476 | Trends in cell biology | 1,996 | ||
Arsenate transport by sodium/phosphate cotransporter type IIb. | Arsenic is a metalloid that causes the dysfunction of critical enzymes, oxidative stress, and malignancies. In recent years several transporters of As(III) have been identified, including aquaglyceroporins (AQP) and multidrug resistance proteins (MRP). As(V) transport, however, has not been sufficiently studied because... | 10.1016/j.taap.2010.05.012 | 20,510,259 | D000818:Animals; D001149:Arsenates; D001693:Biological Transport, Active; D006801:Humans; D051379:Mice; D009865:Oocytes; D051381:Rats; D050614:Sodium-Phosphate Cotransporter Proteins, Type IIb; D014982:Xenopus laevis | Toxicology and applied pharmacology | 2,010 | D001149:Arsenates; D050614:Sodium-Phosphate Cotransporter Proteins, Type IIb; C025657:arsenic acid |
Comparative evaluation of the effect of permeation enhancers, lipid nanoparticles and colloidal silica on in vivo human skin penetration of quercetin. | BACKGROUND/AIM
The aim of this study was to evaluate emulsions containing a penetration enhancer, lipid nanoparticles (LNs) or colloidal silica as systems to improve the topical delivery of the flavonoid quercetin.
METHODS
The skin penetration of quercetin was investigated in vivo on human volunteers by tape strippin... | 10.1159/000345210 | 23,207,877 | D000287:Administration, Topical; D000328:Adult; D000975:Antioxidants; D005026:Ethylene Glycols; D005260:Female; D006801:Humans; D008297:Male; D053758:Nanoparticles; D010713:Phosphatidylcholines; D011794:Quercetin; D012822:Silicon Dioxide; D012867:Skin; D012869:Skin Absorption; D014280:Triglycerides; D055815:Young Adult | Skin pharmacology and physiology | 2,013 | D000975:Antioxidants; D005026:Ethylene Glycols; D010713:Phosphatidylcholines; D014280:Triglycerides; D012822:Silicon Dioxide; D011794:Quercetin; C010111:carbitol; C022618:tristearin |
The application of support vector regression for prediction of the antiallodynic effect of drug combinations in the mouse model of streptozocin-induced diabetic neuropathy. | Drug interactions are an important issue of efficacious and safe pharmacotherapy. Although the use of drug combinations carries the potential risk of enhanced toxicity, when carefully introduced it enables to optimize the therapy and achieve pharmacological effects at doses lower than those of single agents. In view of... | 23,693,136 | D015107:4-Butyrolactone; D000465:Algorithms; D000700:Analgesics; D000818:Animals; D003198:Computer Simulation; D003921:Diabetes Mellitus, Experimental; D003929:Diabetic Neuropathies; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005663:Furans; D006930:Hyperalgesia; D008297:Male; D051379:Mice; D01014... | Computer methods and programs in biomedicine | 2,013 | C547282:3-(4-(3-trifluoromethylphenyl)piperazin-1-yl)dihydrofuran-2-one; D000700:Analgesics; D004338:Drug Combinations; D005663:Furans; D010879:Piperazines; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D013311:Streptozocin; D015107:4-Butyrolactone | |
Analysis of distillation characteristics via CFD (computational fluid dynamics) of Korean traditional 'Sojutgori' and study on structure for distillation efficiency enhancement. | The design of the Korean traditional distiller 'sojutgori' was extracted as a digital sketch, and the internal fluid flow in the distillation process was tracked through computer simulation. Based on this, a new design was derived to improve distillation efficiency and its changes were researched. The ethanol particles... | 10.1002/fsn3.3099 | 36,655,101 | Food science & nutrition | 2,023 | ||
The Importance of Cursive Handwriting Over Typewriting for Learning in the Classroom: A High-Density EEG Study of 12-Year-Old Children and Young Adults. | To write by hand, to type, or to draw - which of these strategies is the most efficient for optimal learning in the classroom? As digital devices are increasingly replacing traditional writing by hand, it is crucial to examine the long-term implications of this practice. High-density electroencephalogram (HD EEG) was u... | 10.3389/fpsyg.2020.01810 | 32,849,069 | Frontiers in psychology | 2,020 | ||
Predictors of poor health-related quality of life among people living with HIV aged ≥60 years in the PISCIS cohort: Findings from the Vive+ project. | INTRODUCTION
Advancements in and accessibility to effective antiretroviral therapy has improved the life expectancy of people living with HIV, increasing the proportion of people living with HIV reaching older age (≥60 years), making this population's health-related quality of life (HRQoL) more relevant. Our aim was to... | 10.1111/hiv.13590 | 38,092,529 | HIV medicine | 2,023 | ||
Unravelling the links between seismo-acoustic signals and eruptive parameters: Etna lava fountain case study. | Deriving eruption source parameters from geophysical data is critical for volcano hazard mitigation, yet remains a challenging task in most volcanoes worldwide. In this work, we explored the temporal relationship between geophysical signals and eruptive parameters measured during six explosive episodes from the New Sou... | 10.1038/s41598-019-52576-w | 31,712,606 | Scientific reports | 2,019 | ||
Biocontrol Agents Increase the Specific Rate of Patulin Production by Penicillium expansum but Decrease the Disease and Total Patulin Contamination of Apples. | Synthetic fungicides are commonly employed for the control of postharvest diseases of fruits. However, due to health concerns about the use of these chemicals, alternative control methods including biocontrol based on antagonistic yeasts are gaining in popularity. In this study, we investigated the effects of two bioco... | 10.3389/fmicb.2017.01240 | 28,713,362 | Frontiers in microbiology | 2,017 | ||
Complex oscillations in a simple model for the Briggs-Rauscher reaction. | Complex oscillations in a simple model of the Briggs-Rauscher reaction mechanism in a continuously stirred tank reactor proposed by Kim et al. [J. Chem. Phys. 117, 2710 (2002)] are investigated numerically. The k(0)-[CH(2)(COOH)(2)](0) phase diagram is constructed first where k(0) is the flow rate and [...](0) is the i... | 10.1063/1.1711591 | 15,281,867 | The Journal of chemical physics | 2,004 | ||
Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. | The functional integrity of the intestinal epithelial barrier forms a major defense against invading pathogens, including gastrointestinal-dwelling nematodes, which are ubiquitous in their distribution worldwide. Here, we show that an increase in the rate of epithelial cell turnover in the large intestine acts like an ... | 10.1126/science.1108661 | 15,933,199 | D000818:Animals; D017209:Apoptosis; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D018793:Interleukin-13; D015847:Interleukin-4; D007411:Intestinal Diseases, Parasitic; D007413:Intestinal Mucosa; D007420:Intestine, Large; D008297:Male; D05137... | Science (New York, N.Y.) | 2,005 | D054357:Chemokine CXCL10; D019743:Chemokines, CXC; C485433:Cxcl10 protein, mouse; D018793:Interleukin-13; D015847:Interleukin-4 |
Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite. | In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were characterized and their anti-inflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the production of nitric oxide, prostaglandin... | 10.1016/j.jsps.2022.02.002 | 35,527,823 | Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society | 2,022 | ||
Risk-taking behaviors of gay and bisexual men in New York City post 9/11. | Until now, the reactions of gay and bisexual populations have been largely overlooked in response to terror and disaster. This study assesses risk-taking behaviors in gay and bisexual men two weeks before and after the 9/11 attacks in Manhattan. For the purposes of this study, risk-taking behaviors include drug use and... | 10.1080/00918369.2010.493422 | 20,665,328 | D000328:Adult; D001727:Bisexuality; D003710:Demography; D015658:HIV Infections; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D009519:New York City; D012309:Risk-Taking; D047851:September 11 Terrorist Attacks; D012725:Sexual Behavior; D019966:Substance-Related Disorders; D047568:Unsafe Sex | Journal of homosexuality | 2,010 | |
Prognostic significance of the nadir prostate specific antigen level after hormone therapy for prostate cancer. | PURPOSE
We determine whether the nadir prostate specific antigen (PSA) level after hormone therapy can be used to predict the progression to hormone refractory prostate cancer.
MATERIALS AND METHODS
We reviewed the progressive status and survival of 177 patients with stage C or D prostate cancer who had received horm... | 10.1016/S0022-5347(05)64559-4 | 12,187,207 | D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011379:Prognosis; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms; D012372:ROC Curve; D012044:Regression Analysis; D012680:Sensitivit... | The Journal of urology | 2,002 | D018931:Antineoplastic Agents, Hormonal; D017430:Prostate-Specific Antigen |
De-identification of clinical notes via recurrent neural network and conditional random field. | De-identification, identifying information from data, such as protected health information (PHI) present in clinical data, is a critical step to enable data to be shared or published. The 2016 Centers of Excellence in Genomic Science (CEGS) Neuropsychiatric Genome-scale and RDOC Individualized Domains (N-GRID) clinical... | 10.1016/j.jbi.2017.05.023 | 28,579,533 | D057286:Electronic Health Records; D020408:Health Insurance Portability and Accountability Act; D006801:Humans; D009323:Natural Language Processing; D016571:Neural Networks, Computer; D014481:United States | Journal of biomedical informatics | 2,017 | |
Phosphorescent Iridium(III) Complexes with Acyclic Diaminocarbene Ligands as Chemosensors for Mercury. | A new application for bis(cyclometalated) iridium(III) species containing ancillary acyclic diaminocarbene ligands, viz. for sensing of mercury(II) ions, is disclosed. A family of bis(cyclometalated) iridium(III) species supported by both parent isocyanide and acyclic diaminocarbene ligands was prepared, and their elec... | 10.1021/acs.inorgchem.9b02833 | 32,011,868 | Inorganic chemistry | 2,020 | ||
Effects of prepartum stocking density and a blind on physiological biomarkers, health, and hygiene of transition Holstein dairy cows. | Many dairy cows succumb to disease after calving. Disease risk may be affected by the cows' social environment and ability to perform maternal behaviors. In nature, cattle isolate from others and find seclusion to give birth; these behaviors may be limited in indoor group pens and could potentially affect the cows' abi... | 10.3168/jds.2020-18718 | 33,162,092 | D020155:3-Hydroxybutyric Acid; D000818:Animals; D015415:Biomarkers; D002417:Cattle; D002418:Cattle Diseases; D003612:Dairying; D005230:Fatty Acids, Nonesterified; D005260:Female; D006242:Haptoglobins; D006799:Housing, Animal; D006920:Hygiene; D007662:Ketosis; D007774:Lactation; D008892:Milk; D058725:Peripartum Period; ... | Journal of dairy science | 2,021 | D015415:Biomarkers; D005230:Fatty Acids, Nonesterified; D006242:Haptoglobins; D020155:3-Hydroxybutyric Acid |
Surgical complications and long-term outcome of different biliary reconstructions in liver transplantation for primary sclerosing cholangitis-choledochoduodenostomy versus choledochojejunostomy. | Choledochojejunostomy (CJS) is commonly used for biliary reconstruction in liver transplantation for primary sclerosing cholangitis (PSC). We alternatively performed choledochoduodenostomy (CDS) and side-to-side choledochodocholedochstomy in a large cohort of patients. Fifty-one patients with PSC, transplanted between ... | 10.1111/j.1600-6143.2005.01173.x | 16,426,324 | D000328:Adult; D015209:Cholangitis, Sclerosing; D002768:Choledochostomy; D005260:Female; D005704:Gallbladder; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D016896:Treatment Outcom... | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons | 2,006 | |
[Evaluation of the teleconsultation process from the perspective of the provider (Oaxaca Telehealth Program, Mexico)]. | OBJECTIVE
Identify barriers to implementation of the teleconsultation process in order to develop strategies to improve the program's operation.
METHODS
A process evaluation strategy was used to study the implementation of the teleconsultation service. The program's operating manuals were compared with the qualitativ... | 28,591,329 | D006801:Humans; D008800:Mexico; D019114:Remote Consultation; D017216:Telemedicine | Revista panamericana de salud publica = Pan American journal of public health | 2,017 | ||
Diversity of Archaea in Icelandic hot springs based on 16S rRNA and chaperonin genes. | The diversity of archaeal communities growing in four hot springs (65-90 °C, pH 6.5) was assessed with 16S rRNA gene primers specific for the domain Archaea. Overall, mainly uncultured members of the Desulfurococcales, the Thermoproteales and the Korarchaeota, were identified. Based on this diversity, a set of chaperon... | 10.1111/j.1574-6941.2011.01095.x | 21,426,367 | D001105:Archaea; D018834:Chaperonin 60; D003001:Cloning, Molecular; D019641:DNA, Archaeal; D045482:Hot Springs; D007055:Iceland; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S | FEMS microbiology ecology | 2,011 | D018834:Chaperonin 60; D019641:DNA, Archaeal; D012336:RNA, Ribosomal, 16S |
The Challenges in Predicting ECMO Survival, and a Path Forward. | Extracorporeal membrane oxygenation (ECMO) support is a life-saving but complex technique for patients suffering from severe cardiac or pulmonary dysfunction. Increasingly greater utilization in the last 15 years means that a suite of mortality risk analytics is both feasible for researchers and required by clinicians,... | 10.1097/MAT.0000000000000572 | 28,338,480 | D015199:Extracorporeal Membrane Oxygenation; D006801:Humans | ASAIO journal (American Society for Artificial Internal Organs : 1992) | 2,017 | |
Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. | BACKGROUND AND PURPOSE
Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells and also has the potential to increase vascular permeability. Therefore, it may contribute to the recovery of brain cells from ischemic insult through potentiating neovascularization or may exacerbate brain damage by for... | 10.1161/01.str.28.10.2039 | 9,341,716 | D000818:Animals; D001157:Arterial Occlusive Diseases; D015152:Blotting, Northern; D015153:Blotting, Western; D001921:Brain; D002536:Cerebral Arteries; D016228:Endothelial Growth Factors; D015870:Gene Expression; D007150:Immunohistochemistry; D008222:Lymphokines; D008297:Male; D009474:Neurons; D010841:Pia Mater; D012333... | Stroke | 1,997 | D016228:Endothelial Growth Factors; D008222:Lymphokines; D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors |
Quantification of subnanomolar amounts of phosphate bound to seryl and threonyl residues in phosphoproteins using alkaline hydrolysis and malachite green. | An assay for protein-bound phosphate with a capacity to determine 100 pmol of phosphate is described. It is based on the combination of two well known methods: the alkaline hydrolysis of phosphate from seryl and threonyl residues in phosphoproteins and the quantification of the released phosphate by the use of malachit... | 10.1006/abio.1993.1468 | 8,250,216 | D000255:Adenosine Triphosphate; D002364:Caseins; D004396:Coloring Agents; D017868:Cyclic AMP-Dependent Protein Kinases; D005340:Fibrinogen; D006657:Histones; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008832:Microchemistry; D010047:Ovalbumin; D010710:Phosphates; D010750:Phosphoproteins; D010766:Phosphoryl... | Analytical biochemistry | 1,993 | D002364:Caseins; D004396:Coloring Agents; D006657:Histones; D010710:Phosphates; D010750:Phosphoproteins; D011479:Protamines; D012394:Rosaniline Dyes; D010769:Phosphothreonine; C005095:malachite green; D010768:Phosphoserine; D000255:Adenosine Triphosphate; D005340:Fibrinogen; D010047:Ovalbumin; D017868:Cyclic AMP-Depend... |
Chain dynamics and crystalline network structure of poly[R-3-hydroxybutyrate-co-4-hydroxybutyrate] as revealed by solid-state NMR. | The chain dynamics and crystalline network structure of poly[R-3-hydroxybutyrate-co-4-hydroxybutyrate] (P(3HB-co-4HB)) were systematically investigated by the combination of various solid-state NMR techniques. High-resolution 13C cross-polarization (CP) and direct-polarization (DP) MAS with selective recycle delay time... | 10.1039/d0sm02216k | 33,881,056 | Soft matter | 2,021 | ||
Neuroimmunomodulatory effect of antibodies against GABA on acute generalized and chronic epileptiform activity. | We studied the possibility of induction of anti-GABA autoantibodies during chronic epileptization of the brain and the effect of systemic intraperitoneal administration of anti-GABA antibodies to C57Bl/6 mice on acute generalized and chronic epileptiform activity. It was found for the first time that chronic epileptiza... | 10.1007/s10517-006-0418-3 | 17,415,462 | D000818:Animals; D001323:Autoantibodies; D004827:Epilepsy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015213:Neuroimmunomodulation; D012640:Seizures; D005680:gamma-Aminobutyric Acid | Bulletin of experimental biology and medicine | 2,006 | D001323:Autoantibodies; D005680:gamma-Aminobutyric Acid |
A Pathway to Assess Genetic Variation of Wheat Germplasm by Multidimensional Traits with Digital Images. | In this paper, a new pathway was proposed to assess the germplasm genetic variation by multidimensional traits of wheat seeds generated from digital images. A machine vision platform was first established to reconstruct wheat germplasm 3D model from omnidirectional image sequences of wheat seeds. Then, multidimensional... | 10.34133/plantphenomics.0119 | 38,026,469 | Plant phenomics (Washington, D.C.) | 2,023 | ||
Potentiometric and further kinetic characterization of the flavin-binding domain of Saccharomyces cerevisiae flavocytochrome b2. Inhibition by anions binding in the active site. | Saccharomyces cerevisiae flavocytochrome b2 (L-lactate:cytochrome c oxido reductase, EC 1.1.2.3) is a homotetramer, with FMN and protoheme IX binding on separate domains. The flavin-binding domains form the enzyme tetrameric core, while the cytochrome b2 domains appear to be mobile around a hinge region (Xia, Z. X., an... | 10.1021/bi602634y | 17,373,777 | D000465:Algorithms; D000838:Anions; D001665:Binding Sites; D005292:Ferricyanides; D005486:Flavin Mononucleotide; D005182:Flavin-Adenine Dinucleotide; D005415:Flavins; D007700:Kinetics; D042844:L-Lactate Dehydrogenase (Cytochrome); D008956:Models, Chemical; D008958:Models, Molecular; D009247:NADH, NADPH Oxidoreductases;... | Biochemistry | 2,007 | D000838:Anions; D005292:Ferricyanides; D005415:Flavins; D029701:Saccharomyces cerevisiae Proteins; C007931:hexacyanoferrate III; D005182:Flavin-Adenine Dinucleotide; C029276:flavin semiquinone; D005486:Flavin Mononucleotide; D042844:L-Lactate Dehydrogenase (Cytochrome); D009247:NADH, NADPH Oxidoreductases; C014227:ferr... |
Principles for enhancing the role of state vocational rehabilitation in IPS-supported employment. | OBJECTIVE
Research has established the Individual Placement and Support (IPS) model of supported employment as an effective approach for persons with severe mental illnesses. This article examines strategies for Vocational Rehabilitation (VR) to enhance employment outcomes through better collaboration with IPS programs... | 10.1037/h0094740 | 23,477,643 | D016832:Employment, Supported; D017144:Focus Groups; D006801:Humans; D007087:Illinois; D001523:Mental Disorders; D012050:Rehabilitation, Vocational; D012424:Rural Population; D014505:Urban Population | Psychiatric rehabilitation journal | 2,013 | |
Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa: The influence of structural stability on bioactivity. | Tridegin is a 66mer cysteine-rich coagulation factor XIIIa (FXI-IIa) inhibitor from the giant amazon leech Haementeria ghilianii of yet unknown disulfide connectivity. This study covers the structural and functional characterization of five different 3-disulfide-bonded tridegin isomers. In addition to three previously ... | 10.1016/j.ejmech.2020.112474 | 32,698,061 | D000595:Amino Acid Sequence; D000818:Animals; D004220:Disulfides; D026122:Factor XIIIa; D005796:Genes; D007536:Isomerism; D007865:Leeches; D062105:Molecular Docking Simulation; D056004:Molecular Dynamics Simulation; D011485:Protein Binding; D011487:Protein Conformation; D012471:Salivary Proteins and Peptides | European journal of medicinal chemistry | 2,020 | D004220:Disulfides; D012471:Salivary Proteins and Peptides; C106835:tridegin; D026122:Factor XIIIa |
[Strongyloides westeri Ihle, 1917 (Nematoda: Strongyloididae). I. Parasitological features of natural infection (author's transl)]. | Patent S. westeri infection is particularly common in unweaned foals (61.2 per cent). It is much less common in foals which have been weaned (15.4 per cent). Examination of the faeces of ten artificially reared foals (free from worms) did not supply any evidence of possible prenatal (intra-uterine) helminth infection. ... | 561,457 | D000818:Animals; D005243:Feces; D005260:Female; D006736:Horses; D007774:Lactation; D007814:Larva; D008892:Milk; D010270:Parasite Egg Count; D011247:Pregnancy; D013319:Strongyle Infections, Equine; D013321:Strongyloides | Tijdschrift voor diergeneeskunde | 1,977 | ||
Sensitive electrochemical detection of copper ions based on the copper(II) ion assisted etching of Au@Ag nanoparticles. | A new sensitive electrochemical sensor for the detection of copper ions based on the copper ion assisted etching of Au@Ag nanoparticles was developed in this work. Since copper ions could greatly catalyze the etching process of the silver shell of Au@Ag nanoparticles in the presence of thiosulfate solutions, leading to... | 10.1039/c5an01888a | 26,501,137 | The Analyst | 2,015 | ||
Perceptions of radiation oncologists and urologists on sources and type of evidence to inform prostate cancer treatment decisions. | PURPOSE
To perform a national survey of radiation oncologists and urologists about the type of resources used and the level of evidence needed to change clinical practice in localized prostate cancer.
METHODS AND MATERIALS
From a random sample, 1422 physicians were mailed a survey assessing the types of information u... | 24,685,153 | D000328:Adult; D003657:Decision Making; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D010506:Periodicals as Topic; D017410:Practice Guidelines as Topic; D011468:Prostatectomy; D011471:Prostatic Neoplasms; D018787:Radiation Oncology; D014572:Urology | International journal of radiation oncology, biology, physics | 2,014 | ||
Pre-habilitation before colorectal cancer surgery could improve postoperative gastrointestinal function recovery: a case-matched study. | PURPOSE
While its effect is controverted, multimodal pre-habilitation could be used to improve the postoperative course following colorectal cancer surgery. However, by increasing lean body mass, pre-habilitation could reduce the time needed to recover gastrointestinal (GI) functions. The aim was to assess the impact o... | 10.1007/s00423-022-02487-8 | 35,260,942 | D015179:Colorectal Neoplasms; D013505:Digestive System Surgical Procedures; D006801:Humans; D007902:Length of Stay; D011183:Postoperative Complications; D020127:Recovery of Function; D012189:Retrospective Studies | Langenbeck's archives of surgery | 2,022 | |
Mutation independently affects reproductive traits and dauer larvae development in mutation accumulation lines of Caenorhabditis elegans. | Developmental decisions are important in organismal fitness. For the nematode Caenorhabditis elegans, which is naturally found in the ephemeral food patches formed by rotting plant material, correctly committing to dauer or non-dauer larval development is key to genotype survival. To investigate the link between reprod... | 10.1007/s00427-017-0596-1 | 29,170,831 | D000220:Adaptation, Biological; D000818:Animals; D017173:Caenorhabditis elegans; D004777:Environment; D007814:Larva; D000067552:Mutation Accumulation | Development genes and evolution | 2,017 | |
Trends in the Burden of Untreated Caries of Permanent Teeth in China, 1993-2017: An Age-Period-Cohort Modeling Study. | INTRODUCTION
This study aims to identify the trends in incidence and prevalence of untreated caries in permanent teeth in China during 1993-2017.
METHODS
Data representing >31 billion person-years of observation from the Global Burden of Disease study 2017 were analyzed. Age-period-cohort modeling was performed to in... | 10.1016/j.amepre.2020.06.012 | 33,153,836 | D000328:Adult; D002681:China; D003733:Dental Caries Susceptibility; D006801:Humans; D015994:Incidence; D009909:Oral Health; D015995:Prevalence; D055815:Young Adult | American journal of preventive medicine | 2,020 | |
Terpenoids from Myrrh and Their Cytotoxic Activity against HeLa Cells. | The oleo-gum resin of Commiphora myrrha (Nees) Engl. has a long history of medicinal use, although many of its constituents are still unknown. In the present investigation, 34 secondary metabolites were isolated from myrrh resin using different chromatographic techniques (silica flash chromatography, CPC, and preparati... | 10.3390/molecules28041637 | 36,838,624 | D006801:Humans; D013729:Terpenes; D029744:Commiphora; D018799:Intercellular Adhesion Molecule-1; D006367:HeLa Cells; D042783:Endothelial Cells; D012116:Resins, Plant; D014315:Triterpenes; D000970:Antineoplastic Agents | Molecules (Basel, Switzerland) | 2,023 | D013729:Terpenes; C587573:myrrh resin; D018799:Intercellular Adhesion Molecule-1; D012116:Resins, Plant; D014315:Triterpenes; D000970:Antineoplastic Agents |
[LINGUISTIC VALIDATION OF JAPANESE VERSION OF THE VULVOVAGINAL SYMPTOMS QUESTIONNAIRE (VSQ)]. | (Purpose) To translate the Vulvovaginal Symptoms Questionnaire (VSQ) into Japanese and evaluate the linguistic validation of the translated VSQ. (Methods) The translation and evaluation of the VSQ were performed through 3 steps: forward translation based on 2 urologists and discussed by another 3 urologists; the commun... | 10.5980/jpnjurol.112.173 | 36,261,346 | Nihon Hinyokika Gakkai zasshi. The japanese journal of urology | 2,021 | ||
[Infiltrated cutaneous leishmaniasis and sporotrichosis caused by Leishmania major. First Senegalese case]. | We report in Senegal a case of infiltrated cutaneous leishmaniasis and sporothricoid due to Leishmania major MON-74. The diagnosis of our case was based on the cytologic, histologic and immunoparasitological examination. The patient was completely cured by 3 courses of 15 days of glucan-time. Our case completes the spe... | 11,346,975 | D000328:Adult; D000818:Animals; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D018320:Leishmania major; D016773:Leishmaniasis, Cutaneous; D008536:Meglumine; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds; D012675:Senegal; D013174:Sporotrichosis | Bulletin de la Societe de pathologie exotique (1990) | 2,001 | D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate | |
Increased regulation. Do the benefits outweigh the costs? | A Florida attorney suggests that regulations designed to control costs, such as the new safe harbor rules, should determine whether the benefits to the public exceeds the cost. | 10,122,298 | D003363:Cost Control; D005431:Florida; D007449:Investments; D007753:Laboratories; D016365:Liability, Legal; D010067:Ownership; D010820:Physicians; D012017:Referral and Consultation; D014481:United States | Southern hospitals | 1,992 | ||
Thyroid imaging in a typical case of acute suppurative thyroiditis with abscess formation due to infection from a persistent thyroglossal duct. | The clinical evaluation of thyroid imaging with 99mTc, 201Tl, and 67Ga in the uncommon, but potentially serious, disorder of acute suppurative thyroiditis (AST) with abscess formation due to infection from a persistent thyroglossal duct is reported. The 99mTc image showed functioning areas of the diseased thyroid gland... | 10.1007/BF03165022 | 8,074,961 | D000038:Abscess; D000328:Adult; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013290:Streptococcal Infections; D013794:Thallium Radioisotopes; D013955:Thyroglossal Cyst; D013961:Thyroid Gland; D013969:Thyroiditis, Suppurative | Annals of nuclear medicine | 1,994 | D005710:Gallium Radioisotopes; D013794:Thallium Radioisotopes; D013670:Sodium Pertechnetate Tc 99m |
The psychology of colonialism: sex, age, and ideology in British India. | It is becoming more and more obvious that colonialism--as we have come to know it during the last two hundred years--cannot be identified with only economic gain and political power. In Manchuria, Japan consistently lost money, and for many years colonial Indochina, Algeria and Angola, instead of increasing the politic... | 10.1080/00332747.1982.11024151 | 7,111,529 | D003466:Cultural Characteristics; D003469:Culture; D006801:Humans; D007194:India; D011057:Politics; D011573:Psychoanalytic Interpretation; D011574:Psychoanalytic Theory; D006113:United Kingdom | Psychiatry | 1,982 | |
Pattern recognition-assisted infrared library searching of automotive clear coats. | Pattern recognition techniques have been developed to search the infrared (IR) spectral libraries of the paint data query (PDQ) database to differentiate between similar but nonidentical IR clear coat paint spectra. The library search system consists of two separate but interrelated components: search prefilters to red... | 10.1366/14-07578 | 25,506,887 | Applied spectroscopy | 2,015 | ||
Pneumonitis with Diffuse Alveolar Hemorrhage Induced by Sho-seiryu-to. | A 78-year-old man presented with acute-onset fever and dyspnea. He had been taking Sho-seiryu-to for allergic rhinitis. A chest radiograph showed diffuse bilateral ground-glass opacities with subpleural sparing, crazy-paving pattern, and traction bronchiectasis. The patient's bronchoalveolar lavage fluid was bloody and... | 10.2169/internalmedicine.8779-16 | 28,883,249 | D000305:Adrenal Cortex Hormones; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid; D004365:Drugs, Chinese Herbal; D006801:Humans; D008297:Male; D011014:Pneumonia; D065631:Rhinitis, Allergic; D016896:Treatment Outcome | Internal medicine (Tokyo, Japan) | 2,017 | D000305:Adrenal Cortex Hormones; D004365:Drugs, Chinese Herbal; C090832:sho-seiryu-to |
Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes. | Coordinated communication among pancreatic islet cells is necessary for maintenance of glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been shown to perturb β cell communication and function. Compelling evidence has implicated extracellular vesicles (EVs) in modulating physiological... | 10.1016/j.celrep.2021.109613 | 34,433,033 | D000818:Animals; D018414:CD8-Positive T-Lymphocytes; D054357:Chemokine CXCL10; D003920:Diabetes Mellitus; D000067128:Extracellular Vesicles; D050417:Insulin-Secreting Cells; D008264:Macrophages; D008297:Male; D008810:Mice, Inbred C57BL; D054367:Receptors, CXCR3 | Cell reports | 2,021 | D054357:Chemokine CXCL10; C485433:Cxcl10 protein, mouse; C515188:Cxcr3 protein, mouse; D054367:Receptors, CXCR3 |
Spatially-oriented EMR for dental surgery. | As digital dental images become widely available, a new Electronic MR system (EMR) will be critical for the success of applying new technology to dental care. This project is designed an image-based and spatially-oriented EMR for dental surgery. A new panoramic image-based annotation model will be developed, which will... | 17,238,766 | D003729:Dental Care; D003814:Dentistry, Operative; D040362:Geographic Information Systems; D006801:Humans; D016347:Medical Records Systems, Computerized; D012984:Software | AMIA ... Annual Symposium proceedings. AMIA Symposium | 2,006 | ||
Dexamethasone selectively inhibits differentiation of cord blood stem cell derived-dendritic cell (DC) precursors into immature DCs. | Perinatal dexamethasone (Dx) alters the immune system leading to increased infections and developmental abnormalities. Dendritic cells (DCs) derived from cord-blood monocytes are especially Dx sensitive and we sought to determine the effects of Dx on cord-blood CD34+-DCs. Distinct stages of cord-blood CD34+-DC developm... | 10.1016/j.cellimm.2005.03.002 | 15,922,722 | D018952:Antigens, CD34; D017209:Apoptosis; D002454:Cell Differentiation; D016207:Cytokines; D003713:Dendritic Cells; D003907:Dexamethasone; D005312:Fetal Blood; D006801:Humans; D010641:Phenotype; D011965:Receptors, Glucocorticoid; D013234:Stem Cells; D013601:T-Lymphocytes | Cellular immunology | 2,004 | D018952:Antigens, CD34; D016207:Cytokines; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone |
[The effect of certain periodic characteristics of the ecosystem on the digestive use of Pieris brassicae (Lepidoptera: pieridae) pupae by a parasitoid (Pimpla instigator F: Hymenoptera: Ichneumonidae]. | The lengthening of photophase when it becomes synchrnous with thermophase, increases the quantitative use of Pieris brassicae by Pimpla instigator (increase of Q.A. and C.U.)P. instigator not only seems to adapt itself to diapausing hosts but also to a long photophase (corresponding to the thermophase)i.e., to all the ... | 807,375 | D000818:Animals; D001835:Body Weight; D005260:Female; D006927:Hymenoptera; D007915:Lepidoptera; D008027:Light; D008297:Male; D010271:Parasites; D010507:Periodicity; D012737:Sex Factors; D013696:Temperature | Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles | 1,975 | ||
Hemodynamic studies, acid-base status and osmolality in different hemodialysis procedures. | Three patients on maintenance dialysis were each treated with three different procedures: A) twenty-liter recirculation dialysis with bicarbonate buffering, B) recirculation-adsorption dialysis and C) single-pass dialysis. Hemodynamic parameters were measured invasively and procedures A, B and C were compared for each ... | 10.1111/j.1525-1594.1978.tb01619.x | 743,003 | D000136:Acid-Base Equilibrium; D000327:Adsorption; D001639:Bicarbonates; D001794:Blood Pressure; D002021:Buffers; D002302:Cardiac Output; D002496:Central Venous Pressure; D005374:Filtration; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D009994:Osmolar Concentration; D006435:Renal Dialysis; D013318:Stroke V... | Artificial organs | 1,978 | D001639:Bicarbonates; D002021:Buffers |
The value of ambulatory blood pressure in older adults: the Dublin outcome study. | BACKGROUND
ambulatory blood pressure (ABPM) appears to be a more accurate predictor of cardiovascular outcome than blood pressure (BP) measured in the clinic setting in younger adults.
OBJECTIVES
the purpose of this study was to determine if ABPM predicted total and cardiovascular mortality independently of clinic BP... | 10.1093/ageing/afm193 | 18,349,014 | D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001795:Blood Pressure Determination; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases; D002423:Cause of Death; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; ... | Age and ageing | 2,008 | |
[Outpatient parenteral antibiotic therapy (OPAT)]. | Traditionally, parenteral (i. e. intravenous) antimicrobial therapy has been used in inpatients with various bacterial infections. In recent decades there has been growing experience with outpatient parenteral antimicrobial therapy, mainly in the USA and western Europe. This article provides basic information on OPAT, ... | 27,256,144 | D000900:Anti-Bacterial Agents; D005060:Europe; D016905:Gram-Negative Bacterial Infections; D016908:Gram-Positive Bacterial Infections; D018718:Home Infusion Therapy; D006801:Humans; D007263:Infusions, Parenteral; D006113:United Kingdom | Casopis lekaru ceskych | 2,016 | D000900:Anti-Bacterial Agents | |
Determinants of hemoglobin variability in stable peritoneal dialysis patients. | PURPOSE
Significant within-patient hemoglobin (Hb) level variability is well recognized in particularly hemodialysis patients. Several factors such as hospitalizations, intercurrent diseases and IV iron therapy are found to be related to Hb variability (Hb-var). In this observational study, we aimed to identify predict... | 10.1007/s11255-014-0700-7 | 24,687,636 | D000328:Adult; D000368:Aged; D000740:Anemia; D059168:Carotid Intima-Media Thickness; D005260:Female; D005293:Ferritins; D006397:Hematinics; D006454:Hemoglobins; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory | International urology and nephrology | 2,014 | D006397:Hematinics; D006454:Hemoglobins; D005293:Ferritins |
Digestion of cell-wall monosaccharides of ryegrass and alfalfa hays by the ruminal bacteria Fibrobacter succinogenes and Butyrivibrio fibrisolvens. | The ruminal bacteria Fibrobacter succinogenes strains S85 and BL2 were grown in monocultures or in coculture with strain D1 of Butyrivibrio fibrisolvens, and the solubilization of ryegrass and alfalfa cell walls (CW) and digestion of CW monosaccharides were measured. Fibrobacter succinogenes monocultures and cocultures... | 10.1139/m93-115 | 8,221,378 | D000818:Animals; D001439:Bacteroides; D002473:Cell Wall; D006089:Gram-Negative Anaerobic Bacteria; D008129:Lolium; D000455:Medicago sativa; D008855:Microscopy, Electron, Scanning; D009005:Monosaccharides; D012417:Rumen | Canadian journal of microbiology | 1,993 | D009005:Monosaccharides |
Effects of magnesium sulphate on the noradrenaline-induced cerebral vasoconstrictor and pressor responses in the goat. | OBJECTIVE
To examine the ability of magnesium sulphate to counteract the noradrenaline-induced cerebral vasoconstrictor and pressor responses in goats by using both in vivo and in vitro techniques.
DESIGN
Cerebral blood flow was measured in vivo by means of an electromagnetic flow probe around the internal maxillary ... | 10.1111/j.1471-0528.1997.tb14348.x | 9,255,080 | D000818:Animals; D001783:Blood Flow Velocity; D002536:Cerebral Arteries; D004305:Dose-Response Relationship, Drug; D005260:Female; D006041:Goats; D066298:In Vitro Techniques; D008278:Magnesium Sulfate; D009638:Norepinephrine; D014655:Vascular Resistance; D014661:Vasoconstriction | British journal of obstetrics and gynaecology | 1,997 | D008278:Magnesium Sulfate; D009638:Norepinephrine |
Evaluation of the Efficacy of Sorafenib on Overall Survival in Patients with Hepatocellular Carcinoma using FT Rate: A Devised Index. | INTRODUCTION
Transcatheter arterial chemoembolization (TACE) is the first-line treatment for intermediate stage hepatocellular carcinoma (HCC) and prolongs survival in HCC patients. However, repeated TACE results in diminished therapeutic response. In addition, the superiority of sorafenib to TACE monotherapy or combin... | 10.1007/s12325-017-0524-9 | 28,389,996 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents; D006528:Carcinoma, Hepatocellular; D016461:Chemoembolization, Therapeutic; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D00953... | Advances in therapy | 2,017 | D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib |
Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Low Back Pain: Two Clinical Case Reports of Sustained Pain Relief. | As the leading cause of disability among U.S. adults, chronic low back pain (LBP) is one of the most prevalent and challenging musculoskeletal conditions. Neuromodulation provides an opportunity to reduce or eliminate the use of opioids to treat chronic LBP, but the cost and invasiveness of existing methods have limite... | 10.1111/papr.12571 | 28,296,137 | D000328:Adult; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D017116:Low Back Pain; D008159:Lumbar Vertebrae; D008875:Middle Aged; D059408:Pain Management; D010147:Pain Measurement; D013127:Spinal Nerves; D013995:Time | Pain practice : the official journal of World Institute of Pain | 2,018 | D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid |
Vascular smooth muscle proliferation: synergistic interaction between serotonin and low density lipoproteins. | OBJECTIVES
The purpose of this study was to examine whether low density lipoproteins (LDLs) or mildly oxidized LDL (mox-LDL) are mitogens for vascular smooth muscle cells (VSMCs) and whether they can act synergistically with serotonin (5HT), a known mitogen for VSMC, in potentiating the proliferative effect of 5HT on V... | 10.1016/s0735-1097(99)00349-6 | 10,551,718 | D000818:Animals; D002455:Cell Division; D008077:Lipoproteins, LDL; D008237:Lysergic Acid; D008934:Mitogens; D009131:Muscle, Smooth, Vascular; D037342:Pertussis Toxin; D011817:Rabbits; D012701:Serotonin; D012702:Serotonin Antagonists; D010566:Virulence Factors, Bordetella | Journal of the American College of Cardiology | 1,999 | D008077:Lipoproteins, LDL; D008934:Mitogens; D012702:Serotonin Antagonists; D010566:Virulence Factors, Bordetella; D012701:Serotonin; D037342:Pertussis Toxin; D008237:Lysergic Acid; C054583:sergolexole |
Assessing the relationship between symptoms and health care utilization in colorectal cancer survivors of different sexual orientations. | OBJECTIVE
The purpose of this study was to determine the association of physical and psychological symptoms with health care utilization in sexual minority and heterosexual colorectal cancer survivors.
METHODS
Four hundred eighteen colorectal cancer survivors who were in remission an average of 3 years after their di... | 10.1007/s00520-021-06157-1 | 33,742,243 | D000073116:Cancer Survivors; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D008297:Male; D010342:Patient Acceptance of Health Care; D012725:Sexual Behavior; D017741:Survivors | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer | 2,021 | |
Endotoxin stimulates in vitro pituitary growth hormone release in eicosanoid-dependent manner. | OBJECTIVE
To investigate the signal transduction pathways by which endotoxin stimulates in vitro pituitary cell growth hormone (GH) release.
ANIMALS
Pituitary cell cultures derived from 6 sheep.
PROCEDURE
Signal transduction pathways involved in endotoxin-mediated GH release from sheep pituitary cell cultures were ... | 8,915,449 | D015117:5,8,11,14-Eicosatetraynoic Acid; D000818:Animals; D001095:Arachidonic Acids; D002121:Calcium Channel Blockers; D017868:Cyclic AMP-Dependent Protein Kinases; D016861:Cyclooxygenase Inhibitors; D004305:Dose-Response Relationship, Drug; D015777:Eicosanoids; D004731:Endotoxins; D013006:Growth Hormone; D066298:In Vi... | American journal of veterinary research | 1,996 | D001095:Arachidonic Acids; D002121:Calcium Channel Blockers; D016861:Cyclooxygenase Inhibitors; D015777:Eicosanoids; D004731:Endotoxins; D016859:Lipoxygenase Inhibitors; D015117:5,8,11,14-Eicosatetraynoic Acid; D009637:Masoprocol; D013006:Growth Hormone; D014700:Verapamil; D017868:Cyclic AMP-Dependent Protein Kinases; ... | |
Diabetic intestinal growth adaptation and glucagon-like peptide 2 in the rat: effects of dietary fibre. | BACKGROUND/AIMS
Dietary fibre influence growth and function of the upper gastrointestinal tract. This study investigates the importance of dietary fibre in intestinal growth in experimental diabetes, and correlates intestinal growth with plasma levels of the intestinotrophic factor, glucagon-like peptide 2 (GLP-2).
M... | 10.1136/gut.45.5.672 | 10,517,902 | D000818:Animals; D003921:Diabetes Mellitus, Experimental; D004043:Dietary Fiber; D053767:Glucagon-Like Peptide 2; D004763:Glucagon-Like Peptides; D007413:Intestinal Mucosa; D007421:Intestine, Small; D008297:Male; D009929:Organ Size; D053772:Oxyntomodulin; D010455:Peptides; D011897:Random Allocation; D051381:Rats; D0172... | Gut | 1,999 | D004043:Dietary Fiber; D053767:Glucagon-Like Peptide 2; D053772:Oxyntomodulin; D010455:Peptides; D004763:Glucagon-Like Peptides |
[Unveiling the daily experience of the hospitalized adolescent]. | My experience in the adolescence was marked by the hospitalization process. Currently, as a nursing professional that take care of hospitalized young, there arose inquietudes that originated this study. The investigation object was the significance of the hospitalization in the adolescence, having as objective to under... | 10.1590/s0034-71672005000200003 | 16,334,177 | D000293:Adolescent; D000298:Adolescent, Hospitalized; D006801:Humans | Revista brasileira de enfermagem | 2,005 | |
Neurogenic potential of hESC-derived human radial glia is amplified by human fetal cells. | The efficient production of human neocortical neurons from human embryonic stem cells (hESC) is the primary requirement for studying early stages of human cortical development. We used hESC to obtain radial glial cells (hESC-RG) and then compared them with RG cells isolated from human fetal forebrain. Fate of hESC-RG c... | 23,651,582 | D002454:Cell Differentiation; D048708:Cell Growth Processes; D002470:Cell Survival; D002478:Cells, Cultured; D018920:Coculture Techniques; D053595:Embryonic Stem Cells; D005333:Fetus; D006801:Humans; D009419:Nerve Tissue Proteins; D009457:Neuroglia; D009474:Neurons; D016548:Prosencephalon | Stem cell research | 2,013 | D009419:Nerve Tissue Proteins | |
Retinal thickness changes after phacoemulsification. | PURPOSE
To determine the effect of phacoemulsification on macular volume and thickness using spectral domain optical coherence tomography examinations.
METHODS
Twenty-seven eyes of 27 subjects who underwent phacoemulsification were studied. All nine areas of the macula were examined by spectral domain optical coheren... | 10.2147/OPTH.S53223 | 24,235,812 | Clinical ophthalmology (Auckland, N.Z.) | 2,013 | ||
Amyloid-β sequester proteins as blood-based biomarkers of cognitive decline. | INTRODUCTION
There are no blood-based biomarkers for cognitive decline in aging, or mild cognitive impairment (MCI) and Alzheimer's disease (AD). Cumulative evidence suggests that apolipoproteins, complement system, and transthyretin are involved in AD pathogenesis by sequestration of amyloid β. However, there is no cl... | 10.1016/j.dadm.2015.04.003 | 27,239,510 | Alzheimer's & dementia (Amsterdam, Netherlands) | 2,015 | ||
[Microvascular reactivity and transcapillary fluid exchange in the lungs]. | In anesthetized cats and rabbits responses of terminal pulmonary vessels to alveolar hypoxia, noradrenaline, histamin, acetylcholine and serotonine, were studied. The role of the vascular bed tone in regulation of pulmonary filtration-absorption function, was studied. A low motor activity of pulmonary microvessels was ... | 1,665,816 | D000042:Absorption; D000818:Animals; D002196:Capillaries; D002199:Capillary Permeability; D002415:Cats; D015633:Extravascular Lung Water; D006874:Hydrostatic Pressure; D000860:Hypoxia; D008168:Lung; D008833:Microcirculation; D008853:Microscopy; D011650:Pulmonary Alveoli; D011817:Rabbits; D014662:Vasoconstrictor Agents;... | Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova | 1,991 | D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents | |
Quantitative hemodynamics by Doppler echocardiography: a noninvasive alternative to cardiac catheterization. | Doppler echocardiography has greatly enhanced the information provided by two-dimensional echocardiography. By providing information concerning pressure gradients, intracardiac pressures, volumetric flow, and diastolic filling of the heart, most hemodynamic information that in the past could be obtained only from cardi... | 10.1016/s0033-0620(05)80037-4 | 8,284,434 | D006328:Cardiac Catheterization; D015150:Echocardiography, Doppler; D006349:Heart Valve Diseases; D006439:Hemodynamics; D006801:Humans; D014694:Ventricular Outflow Obstruction | Progress in cardiovascular diseases | 1,994 | |
A multi-purpose rehabilitation frame: an apparatus for experimental investigations of human balance and postural control. | Moving and rotating platforms are often used in experimental investigations of human balance and postural control. These devices are not well suited for testing elderly and neurologically impaired individuals, because of inherent risk of injury to the experimental subject due to a potential fall. This paper describes a... | 10.1080/030919000300037186 | 11,315,651 | D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D004867:Equipment Design; D006801:Humans; D004856:Postural Balance; D011187:Posture; D012046:Rehabilitation | Journal of medical engineering & technology | 2,000 | |
The interaction of education and cumulative lead exposure on the Mini-Mental State Examination. | The effect of lead exposure on neurobehavioral performance is modified by age. Whether educational achievement can serve as an effect modifier on the lead-cognitive performance relationship is examined. The Mini-Mental State Examination (MMSE) and the reading section of the Wide Range Achievement Test-Revised (WRAT-R),... | 10.1097/00043764-200206000-00021 | 12,085,485 | D000328:Adult; D000395:Air Pollutants, Occupational; D004305:Dose-Response Relationship, Drug; D004522:Educational Status; D005260:Female; D006801:Humans; D007854:Lead; D020265:Lead Poisoning, Nervous System, Adult; D008297:Male; D008396:Maryland; D008609:Mental Status Schedule; D008875:Middle Aged; D009784:Occupationa... | Journal of occupational and environmental medicine | 2,002 | D000395:Air Pollutants, Occupational; D007854:Lead |
A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. | Tumor suppressor p53 prevents early death due to cancer development. However, the role of p53 in aging process and longevity has not been well-established. In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 act... | 29,557,783 | D000375:Aging; D000483:Alleles; D019943:Amino Acid Substitution; D000818:Animals; D003062:Codon; D006801:Humans; D008136:Longevity; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D023421:Models, Animal; D020125:Mutation, Missense; D020641:Polymorphism, Single Nucleotide; D019076:Transge... | eLife | 2,018 | D003062:Codon; D016159:Tumor Suppressor Protein p53 | |
Core guidelines for the discharge home of the child on long-term assisted ventilation in the United Kingdom. UK Working Party on Paediatric Long Term Ventilation. | Paediatric home ventilation is a feasible option and can be successful in a wide range of conditions and ages. Advances in ventilator technology and an ethos of optimism for home care has increased the possibilities for discharging chronically ventilated children from intensive care units and acute medical beds. With c... | 10.1136/thx.53.9.762 | 10,319,058 | D017028:Caregivers; D002648:Child; D002675:Child, Preschool; D003142:Communication; D003657:Decision Making; D006699:Home Care Services; D006801:Humans; D008134:Long-Term Care; D008173:Lung Diseases, Obstructive; D020380:Needs Assessment; D010347:Patient Care Planning; D010348:Patient Care Team; D010351:Patient Dischar... | Thorax | 1,998 | |
Are there any realistic chances to develop new drugs for asthma? | Asthma bronchiale, an inflammatory airway disease, imposes a significant health care problem worldwide. It is characterized by three critical phenotypic traits: intermittent and reversible bronchoconstriction, bronchial hyperresponsiveness and airway inflammation. Conventional therapy basically consists of beta(2)-adre... | 10.1358/dnp.2006.19.4.985935 | 16,823,494 | D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D018927:Anti-Asthmatic Agents; D001249:Asthma; D001993:Bronchodilator Agents; D018925:Chemokines; D000529:Complementary Therapies; D015316:Genetic Therapy; D006801:Humans; D007114:Immunization; D018836:Inflammation Mediators; D061965:Mat... | Drug news & perspectives | 2,006 | D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D018925:Chemokines; D018836:Inflammation Mediators; D061965:Matrix Metalloproteinase Inhibitors; D016328:NF-kappa B; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases; D011505:Protein-Tyrosine Kinases; D020928:Mitogen-Ac... |
Coronary artery bypass grafting without cardiopulmonary bypass and without interruption of native coronary flow using a novel anastomosis site restraining device ("Octopus"). | OBJECTIVE
This study assessed the feasibility of coronary artery bypass grafting on the beating heart without interruption of native coronary blood flow using a novel anastomosis site restraining device.
BACKGROUND
Recently, an end-to-side bypass technique was described that does not require interruption of flow in t... | 10.1016/0735-1097(96)00039-3 | 8,626,944 | D000768:Anesthesia, General; D000818:Animals; D003331:Coronary Vessels; D015716:Electrocardiography, Ambulatory; D005500:Follow-Up Studies; D006439:Hemodynamics; D006801:Humans; D007387:Internal Mammary-Coronary Artery Anastomosis; D053685:Laser Therapy; D008991:Monitoring, Physiologic; D013396:Suction; D013552:Swine | Journal of the American College of Cardiology | 1,996 | |
Leukotriene synthesis in response to A23187 is inhibited by methyl- beta-cyclodextrin in RBL-2H3 cells. | Leukotrienes (LTs) are produced by several biosynthetic enzymes including cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LO), and 5-lipoxygenase activating protein (FLAP) in the perinuclear area. In the present study, we showed that pretreatment with methyl-beta-cyclodextrin (MbetaCD), a cholesterol-depleting ag... | 17,464,212 | D058927:5-Lipoxygenase-Activating Proteins; D000818:Animals; D016718:Arachidonic Acid; D000001:Calcimycin; D002118:Calcium; D002352:Carrier Proteins; D045744:Cell Line, Tumor; D003545:Cysteine; D015289:Leukotrienes; D021962:Membrane Microdomains; D008565:Membrane Proteins; D021381:Protein Transport; D051381:Rats; D0473... | Molecules and cells | 2,007 | D058927:5-Lipoxygenase-Activating Proteins; D002352:Carrier Proteins; D015289:Leukotrienes; D008565:Membrane Proteins; D047392:beta-Cyclodextrins; C112381:cysteinyl-leukotriene; C106354:flotillins; C108732:methyl-beta-cyclodextrin; D016718:Arachidonic Acid; D000001:Calcimycin; D003545:Cysteine; D002118:Calcium | |
Development of failure detection system based on vibration signal for smart artificial heart: in vitro study. | To realize safe and effective medical treatment for patients with implantable artificial hearts, we have developed a smart artificial heart (SAH). The SAH can grasp the mechanical condition of the artificial heart and the physiological condition of the patient. The purpose of this study is to develop a failure detectio... | 10.1109/IEMBS.2008.4649248 | 19,162,751 | D000465:Algorithms; D003936:Diagnosis, Computer-Assisted; D019544:Equipment Failure Analysis; D006326:Heart Auscultation; D006354:Heart, Artificial; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013813:Therapy, Computer-Assisted; D014732:Vibration | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference | 2,008 | |
Identification of MET exon14 skipping by targeted DNA- and RNA-based next-generation sequencing in pulmonary sarcomatoid carcinomas. | BACKGROUND
Pulmonary sarcomatoid carcinomas (PSCs) constitutes a heterogeneous group of NSCLCs, which show poor prognosis even with aggressive surgical treatment and postoperative chemotherapy. The detection MET exon14 skipping (METex14 skipping) in PSCs suggests the targeted therapeutic opportunities with MET TKIs.
... | 10.1016/j.lungcan.2018.06.001 | 30,032,818 | D063646:Carcinogenesis; D002289:Carcinoma, Non-Small-Cell Lung; D002681:China; D004247:DNA; D005091:Exons; D005260:Female; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D009154:Mutation; D019859:Proto-Oncogene Proteins c-met; D012313:RNA; D0160... | Lung cancer (Amsterdam, Netherlands) | 2,018 | D012313:RNA; D004247:DNA; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met |
Towards the Objective Speech Assessment of Smoking Status based on Voice Features: A Review of the Literature. | BACKGROUND AND OBJECTIVE
In smoking cessation clinical research and practice, objective validation of self-reported smoking status is crucial for ensuring the reliability of the primary outcome, that is, smoking abstinence. Speech signals convey important information about a speaker, such as age, gender, body size, emo... | 10.1016/j.jvoice.2020.12.014 | 33,495,036 | D006801:Humans; D013060:Speech; D014833:Voice Quality; D012907:Smoking; D015203:Reproducibility of Results; D013061:Speech Acoustics | Journal of voice : official journal of the Voice Foundation | 2,023 | |
Single-cell RNA-seq with spatial transcriptomics to create an atlas of human diabetic kidney disease. | Diabetic kidney disease (DKD) develops in ~40% of patients with diabetes and is the leading cause of chronic kidney disease worldwide. We used single-cell RNA-sequencing and spatial transcriptomic analyses of kidney specimens from patients with DKD. Unsupervised clustering revealed distinct cell clusters, including epi... | 10.1096/fj.202202013RR | 37,130,011 | D006801:Humans; D003928:Diabetic Nephropathies; D042783:Endothelial Cells; D059467:Transcriptome; D000092386:Single-Cell Gene Expression Analysis; D007668:Kidney; D003920:Diabetes Mellitus | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 2,023 | |
The efficacy of screening for carcinoma of the prostate by digital examination. | Screening for carcinoma of the prostate by digital examination has been frequently advocated. In the United States prostate cancer is an important health problem for which current treatment is unsatisfactory; most patients with progressive disease die of the condition. While the pattern of spread of prostate cancer is ... | 3,916,716 | D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010173:Palpation; D011471:Prostatic Neoplasms; D014481:United States | American journal of preventive medicine | 1,985 | ||
Subpectoral biceps tenodesis with interference screw fixation. | The proximal portion of the long head of the biceps is a recognized cause of anterior shoulder pain. This article presents a novel technique for tenodesing the proximal biceps tendon. The tendon is evaluated and tenodesed in the same anatomic position beneath the pectoralis tendon, and is removed entirely from the bici... | 10.1016/j.arthro.2005.04.002 | 16,012,508 | D001863:Bone Screws; D006801:Humans; D016268:Internal Fixators; D018482:Muscle, Skeletal; D013710:Tendons | Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association | 2,005 | |
Directional Deep Brain Stimulation of the Posteromedial Hypothalamus for Refractory Intermittent Explosive Disorder: A Case Series Using a Novel Neurostimulation Device and Intraoperative Microdialysis. | BACKGROUND
Intermittent explosive disorder (IED) is a psychiatric disorder characterized by recurrent outbursts of aggressive behavior. Deep brain stimulation (DBS) in the posteromedial nucleus of the hypothalamus (pHyp) is an alternative therapy for extreme cases and shows promising results. Intraoperative microdialys... | 10.1016/j.wneu.2021.07.086 | 34,325,026 | D000328:Adult; D046690:Deep Brain Stimulation; D007174:Disruptive, Impulse Control, and Conduct Disorders; D005260:Female; D006801:Humans; D007031:Hypothalamus; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult | World neurosurgery | 2,021 | |
A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. | Using an ATP analog that is a specific substrate for an analog-specific allele of v-Src, we identified several novel cytoskeletal substrates that control actin assembly processes. A screen for less abundant v-Src substrates revealed the scaffolding protein Dok-1 as a direct substrate of v-Src. Further studies suggest t... | 10.1016/s1074-5521(02)00086-8 | 11,841,937 | D016475:3T3 Cells; D000818:Animals; D004268:DNA-Binding Proteins; D051379:Mice; D009154:Mutation; D015688:Oncogene Protein pp60(v-src); D010750:Phosphoproteins; D010766:Phosphorylation; D016601:RNA-Binding Proteins; D015398:Signal Transduction; D013379:Substrate Specificity | Chemistry & biology | 2,002 | D004268:DNA-Binding Proteins; C489561:Dok1 protein, mouse; C074561:GAP-associated protein p62; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D015688:Oncogene Protein pp60(v-src) |
Quantitative discomanometry: technique and reproducibility in vitro. | Quantitative discomanometry is a study of intradiscal pressure and volume measurements during the injection of fluid into an endplate-disc-endplate complex. The purpose of this article was to describe the technique of quantitative discomanometry, determine the reproducibility of the injection technique in a cadaveric t... | 9,726,304 | D000368:Aged; D002102:Cadaver; D004867:Equipment Design; D006801:Humans; D007278:Injections, Spinal; D007403:Intervertebral Disc; D008159:Lumbar Vertebrae; D008365:Manometry; D015203:Reproducibility of Results; D012965:Sodium Chloride; D013904:Thoracic Vertebrae | Journal of spinal disorders | 1,998 | D012965:Sodium Chloride | |
SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells. | Previous studies have implicated cancer stem cells in tumor recurrence and revealed that the stem cell gene SOX2 plays an important role in the tumor cell resistance to apoptosis. Nonetheless, the mechanism by which SOX2 regulates apoptosis signals remained undefined. Here, we demonstrated the surprising finding that s... | 10.1093/carcin/bgt371 | 24,233,838 | D000818:Animals; D017209:Apoptosis; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D020868:Gene Silencing; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D016513:Mice, SCID; D017346:Protein Serine-Threonine Kinases; D055748:S... | Carcinogenesis | 2,014 | C107489:BIRC5 protein, human; D017931:DNA Primers; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; D000077022:Survivin; C117090:MAP4K4 protein, human; D017346:Protein Serine-Threonine Kinases |
Improvement of a rapid diagnosis kit to detect either influenza A or B virus infections. | To improve the sensitivity of a kit, ESPLINE INFLUENZA A&B for rapid diagnosis of influenza by detecting influenza A or B virus specific nucleoproteins (NP), the ESPLINE INFLUENZA A&B-N was developed by using newly established monoclonal antibodies (MAbs) to the respective NP molecule. MAbs FVA2-11 and FrB1-03 recogniz... | 10.1292/jvms.68.35 | 16,462,114 | D000818:Animals; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D015153:Blotting, Western; D000939:Epitopes; D006801:Humans; D009980:Influenza A virus; D009981:Influenza B virus; D009698:Nucleoproteins; D009976:Orthomyxoviridae Infections; D011933:Reagent Kits, Diagnostic | The Journal of veterinary medical science | 2,006 | D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes; D009698:Nucleoproteins; D011933:Reagent Kits, Diagnostic |
Role of macrophages in the biological reaction to wear debris from joint replacements. | Normal usage of total joint replacements results in the production of wear debris and other byproducts. In particular, polyethylene particles are heavily involved in the stimulation of local and systemic biological reactions resulting in chronic inflammation, periprosthetic bone resorption (osteolysis), and, eventually... | 10.1615/jlongtermeffmedimplants.2014010562 | 25,747,029 | D019643:Arthroplasty, Replacement; D016207:Cytokines; D006801:Humans; D007595:Joint Prosthesis; D008264:Macrophages; D010014:Osteolysis; D011474:Prosthesis Design; D011475:Prosthesis Failure | Journal of long-term effects of medical implants | 2,014 | D016207:Cytokines |
Aggressive surgical resection does not improve survival in operable esophageal squamous cell carcinoma with N2-3 status. | AIM
To investigate the influence of nodal status on response and clarify the optimal treatment for operable esophageal squamous cell carcinoma (OSCC).
METHODS
We retrospectively analyzed 1490 OSCC patients who underwent transthoracic esophagectomy and lymphadenectomy between December 1996 and December 2009 at the Sun... | 10.3748/wjg.v21.i28.8644 | 26,229,406 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell; D059186:Chemoradiotherapy, Adjuvant; D017024:Chemotherapy, Adjuvant; D002681:China; D004938:Esophageal Neoplasms; D000077277:Esophageal Squamous Cell Carcinoma; D016629:Esophagectomy; D005260:Female; D006801:Humans; D053208:Kaplan... | World journal of gastroenterology | 2,015 | |
Effects of cyclic AMP on components of the cell cycle machinery regulating DNA synthesis in cultured astrocytes. | Cyclic AMP is a second messenger for various hormones that inhibits cell multiplication and DNA synthesis in cultured astrocytes. We examined the effects of increasing intracellular cyclic AMP on the catalytic (cdks) and regulatory (cyclins and ckis) components of cyclin-dependent protein kinases, which regulate progre... | 10.1046/j.1471-4159.1999.0731799.x | 10,537,037 | D000818:Animals; D001253:Astrocytes; D016203:CDC2 Protein Kinase; D042846:CDC2-CDC28 Kinases; D002453:Cell Cycle; D002460:Cell Line; D002478:Cells, Cultured; D000242:Cyclic AMP; D019925:Cyclin A; D019938:Cyclin D1; D019927:Cyclin E; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases; D004247:DNA; D0158... | Journal of neurochemistry | 1,999 | D019925:Cyclin A; D019927:Cyclin E; D016212:Transforming Growth Factor beta; D019938:Cyclin D1; D004247:DNA; D000242:Cyclic AMP; D017346:Protein Serine-Threonine Kinases; D016203:CDC2 Protein Kinase; D042846:CDC2-CDC28 Kinases; C495892:Cdk2 protein, rat; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinas... |
Cigarette smoking in living kidney donors: donor and recipient outcomes. | BACKGROUND
Living kidney donor pools are expanding with the use of "medically complex" donors. Whether or not to include cigarette smokers as living kidney donors remains unclear. The aim of this study was to determine the relationship between donor smoking and recipient outcomes. We hypothesized that donor smoking wou... | 10.1111/ctr.12330 | 24,617,506 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011... | Clinical transplantation | 2,014 | |
Combining Coronary with Carotid and Cerebrovascular Angiography Using Prospective ECG Gating and Iterative Reconstruction with 256-slice CT. | OBJECTIVE
To investigate the image quality and radiation dose of combined coronary and carotid/cerebrovascular angiography with ECG gating and iterative reconstruction using 256-slice CT compared with the findings with the two examinations performed separately.
PATIENTS AND METHODS
One hundred sixty-five consecutive ... | 10.1111/echo.12830 | 25,371,093 | D050197:Atherosclerosis; D055424:Cardiac-Gated Imaging Techniques; D002339:Carotid Arteries; D002533:Cerebral Angiography; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D064847:Multimodal Imaging; D011829:Radiation Dosage; D00... | Echocardiography (Mount Kisco, N.Y.) | 2,015 |
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