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Ligand mediated activation of ectopic EGF receptor promotes matrix protein adhesion and lung colonization of rat mammary adenocarcinoma cells. | Increased expression of EGF receptor (EGFR) in metastases of human mammary carcinoma as compared to cells of the primary cancer suggests a contribution of EGFR to mammary carcinoma metastasis. To test for a positive causative link, we investigated 13762NF rat mammary adenocarcinoma cloned tumor cell lines of high (MTLn... | 7,753,557 | D000230:Adenocarcinoma; D000818:Animals; D002448:Cell Adhesion; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D005109:Extracellular Matrix; D005260:Female; D008024:Ligands; D008175:Lung Neoplasms; D008325:Mammary Neoplasms, Experimental; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:... | Oncogene | 1,995 | D008024:Ligands; D004815:Epidermal Growth Factor; D066246:ErbB Receptors | |
Malaria in Pregnancy Is a Predictor of Infant Haemoglobin Concentrations during the First Year of Life in Benin, West Africa. | BACKGROUND
Anaemia is an increasingly recognized health problem in Africa, particularly in infants and pregnant women. Although malaria is known to be the main risk factor of anaemia in both groups, the consequences of maternal factors, particularly malaria in pregnancy (MiP), on infant haemoglobin (Hb) concentrations ... | 10.1371/journal.pone.0129510 | 26,052,704 | D000328:Adult; D000354:Africa, Western; D036861:Delivery, Obstetric; D005260:Female; D006454:Hemoglobins; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D008288:Malaria; D015999:Multivariate Analysis; D018512:Parasitemia; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic; D0... | PloS one | 2,015 | D006454:Hemoglobins |
Postremission treatment of elderly patients with acute myeloid leukemia in first complete remission after intensive induction chemotherapy: results of the multicenter randomized Acute Leukemia French Association (ALFA) 9803 trial. | In elderly patients with acute myeloid leukemia (AML) treated intensively, no best postremission strategy has emerged yet. This clinical trial enrolled 416 patients with AML aged 65 years or older who were considered eligible for standard intensive chemotherapy, with a first randomization comparing idarubicin with daun... | 10.1182/blood-2007-02-069666 | 17,341,661 | D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D001803:Blood Transfusion; D003630:Daunorubicin; D018572:Disease-Free Survival; D005260:Female; D006760:Hospitalization; D006801:Humans; D015255:Idarubicin; D007951:Leukemia, Myeloid; D008297:Mal... | Blood | 2,007 | D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D015255:Idarubicin; D003630:Daunorubicin |
The faecal scent of inflammatory bowel disease: Detection and monitoring based on volatile organic compound analysis. | BACKGROUND
Inflammatory bowel disease (IBD) is diagnosed and monitored using endoscopic assessment, which is invasive and costly. In this study, potential of faecal volatile organic compounds (VOC) analysis for IBD detection and identification of disease activity was evaluated.
METHODS
IBD patients visiting outpatien... | 10.1016/j.dld.2020.03.007 | 32,402,741 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001944:Breath Tests; D016022:Case-Control Studies; D003093:Colitis, Ulcerative; D003113:Colonoscopy; D003424:Crohn Disease; D005243:Feces; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases; D000075663:Ion ... | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver | 2,020 | D015415:Biomarkers; D055549:Volatile Organic Compounds |
Low field strength magnetic resonance imaging of bone marrow in acute leukaemia. | The accuracy of low field strength (0.08 Tesla) magnetic resonance imaging (MRI) of bone marrow for the detection of acute leukaemia in adults has been assessed by comparison with bone marrow biopsy results. Spin lattice relaxation time (T1) measurements from patients were compared with those from 90 volunteers. Eighte... | 10.1002/hon.2900060403 | 3,181,877 | D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001853:Bone Marrow; D005260:Female; D006801:Humans; D007938:Leukemia; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged | Hematological oncology | 1,988 | |
Structure, Variation, and Co-occurrence of Soil Microbial Communities in Abandoned Sites of a Rare Earth Elements Mine. | Mining activity for rare earth elements (REEs) has caused serious environmental pollution, particularly for soil ecosystems. However, the effects of REEs on soil microbiota are still poorly understood. In this study, soils were collected from abandoned sites of a REEs mine, and the structure, diversity, and co-occurren... | 10.1021/acs.est.6b02284 | 27,670,106 | D001419:Bacteria; D008674:Metals, Rare Earth; D008906:Mining; D012336:RNA, Ribosomal, 16S; D012987:Soil; D012988:Soil Microbiology | Environmental science & technology | 2,016 | D008674:Metals, Rare Earth; D012336:RNA, Ribosomal, 16S; D012987:Soil |
Effect of 5-bromodeoxyuridine on chromatin transcription in confluent fibroblasts. | 3T6 mouse fibroblasts were grown in 5-bromodeoxyuridine (BrdU) so that approximately 20% of the thymine residues in DNA were replaced by BrdU. BrdU replacement caused an alteration in the relative incorporation of labeled nucleotide precursors into RNA. The RNA synthesized by cells grown in BrdU has a lower proportion ... | 10.1073/pnas.71.2.455 | 4,592,691 | D000241:Adenosine; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D000818:Animals; D001973:Bromodeoxyuridine; D002460:Cell Line; D002843:Chromatin; D003597:Cytosine Nucleotides; D012321:DNA-Directed RNA Polymerases; D004926:Escherichia coli; D005347:Fibroblasts; D006151:Guanosine; D006160:Guanosine Tr... | Proceedings of the National Academy of Sciences of the United States of America | 1,974 | D002843:Chromatin; D003597:Cytosine Nucleotides; D014500:Uracil Nucleotides; D014316:Tritium; D006151:Guanosine; D000249:Adenosine Monophosphate; D012313:RNA; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D012321:DNA-Directed RNA Polymerases; D001973:Bromodeoxyuridine; D000241:Adenosine; D014529:Uridi... |
[Lower limb blocks in children]. | Conduction blocks have important advantage over spinal blocks for unilateral low extremity surgery in children. The complexity of innervation compared with upper limb is more apparent than real and a good understanding of fascial diffusion spaces is as essential as it is of neural pathways. Useful techniques can be cla... | 8,287,307 | D001340:Autonomic Nerve Block; D001917:Brachial Plexus; D002648:Child; D005267:Femoral Nerve; D006801:Humans; D007866:Leg; D008160:Lumbosacral Plexus; D010372:Pediatrics; D012584:Sciatic Nerve | Cahiers d'anesthesiologie | 1,993 | ||
The role of care in nutrition programmes: current research and a research agenda. | The importance of cultural and behavioural factors in children's nutrition, particularly with regard to feeding, has been recognized only recently. The combination of evidence regarding the importance of caregiving behaviour for good nutrition, and improved strategies for measuring behaviour have led to a renewed inter... | 10.1017/s0029665100000045 | 10,828,171 | D017028:Caregivers; D004435:Eating; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D009752:Nutritional Status; D012106:Research | The Proceedings of the Nutrition Society | 2,000 | |
Oral sedation. | "I fear a trip to the dentist more than I fear death" is the response one person gave in a national survey recently cited in USA Today. While clearly representing an extreme, the results of many surveys suggest that fear of dentistry is still prevalent and is a measure of the failure of current therapeutic approaches t... | 9,852,800 | D000284:Administration, Oral; D000465:Algorithms; D000766:Anesthesia, Dental; D014151:Anti-Anxiety Agents; D002697:Chloral Hydrate; D016292:Conscious Sedation; D016854:Dental Anxiety; D003975:Diazepam; D006634:Histamine H1 Antagonists; D006801:Humans; D006919:Hydroxyzine; D006993:Hypnotics and Sedatives; D008874:Midazo... | Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) | 1,998 | D014151:Anti-Anxiety Agents; D006634:Histamine H1 Antagonists; D006993:Hypnotics and Sedatives; D009153:Mutagens; D014229:Triazolam; D006919:Hydroxyzine; D002697:Chloral Hydrate; D003975:Diazepam; D008874:Midazolam | |
Sinonasal myxoma: a pediatric case. | The authors report a case of a rare facial myxoma arising from the maxillary sinus in a 20-month-old child. The diagnosis was confirmed by a biopsy, and the patient underwent a partial maxillectomy to achieve a total resection of the mass due to the locally aggressive nature of the lesion. Myxomas should be differentia... | 10.1097/01.mph.0000153443.36193.de | 15,701,983 | D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008444:Maxillary Sinus Neoplasms; D009232:Myxoma | Journal of pediatric hematology/oncology | 2,005 | |
[Five years of renal trauma in a paediatric trauma center: new tools in the diagnostic and therapeutic process]. | INTRODUCTION
There is general agreement in the conservative management of most renal traumas, but questions like the role of angiography are still controversial. Our objective is to review the paediatric renal trauma characteristics, propose a therapeutic protocol and suggest new therapeutic tools.
MATERIAL AND METHO... | 18,351,241 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003663:Decision Trees; D006801:Humans; D007668:Kidney; D012189:Retrospective Studies; D013997:Time Factors; D014947:Wounds and Injuries | Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica | 2,007 | ||
SARS-CoV-2 and Nervous System - Neurological Manifestations in Patients With COVID-19: A Systematic Review. | Coronavirus (CoV) is a virus infectious disease with a considerable spectrum of clinical presentations. Symptoms ranged from asymptomatic infection to severe pneumonia that may lead to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and several clinical complications. Neurologic symptoms related to CoV hav... | 10.14740/jnr602 | 33,984,094 | Journal of neurology research | 2,020 | ||
Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer. | BACKGROUND
Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumorigenesis. Recently, we demonstrated that aldehyde dehydrogenase 1B1 (ALDH1B1) knockdown dramatically reduced colon tumor growth in a mouse xenograft ... | 10.1016/j.cbi.2020.109274 | 33,007,288 | D011125:Adenomatous Polyposis Coli; D000080924:Aldehyde Dehydrogenase 1 Family; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000818:Animals; D015179:Colorectal Neoplasms; D004195:Disease Models, Animal; D005838:Genotype; D007420:Intestine, Large; D007421:Intestine, Small; D051379:Mice; D018345:Mice, Knockout; D01... | Chemico-biological interactions | 2,020 | C000628667:Trp53 protein, mouse; D016159:Tumor Suppressor Protein p53; D051176:beta Catenin; D013629:Tamoxifen; D000080924:Aldehyde Dehydrogenase 1 Family; C578830:ALDH1B1 protein, mouse; D000071396:Aldehyde Dehydrogenase, Mitochondrial |
Targeted analysis of genomic regions enriched in African ancestry reveals novel classical HLA alleles associated with asthma in Southwestern Europeans. | Despite asthma has a considerable genetic component, an important proportion of genetic risks remain unknown, especially for non-European populations. Canary Islanders have the largest African genetic ancestry observed among Southwestern Europeans and the highest asthma prevalence in Spain. Here we examined broad chrom... | 10.1038/s41598-021-02893-w | 34,880,287 | D000328:Adult; D000483:Alleles; D001249:Asthma; D044383:Black People; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005260:Female; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006680:HLA Antigens; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio... | Scientific reports | 2,021 | D006680:HLA Antigens |
Regulatory properties of 14-day embryo and adult hen skeletal muscle AMP deaminase. | Chromatography on phosphocellulose column revealed changes in the elution profile of 14 day-old chicken embryo and adult hen skeletal muscle AMP deaminase. In the presence of 5 mM potassium the enzyme from embryo muscle exhibited a sigmoid-shaped plot of the reaction rate versus substrate concentration. The increase of... | 10.1016/0304-4165(83)90194-0 | 6,882,796 | D000659:AMP Deaminase; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D006160:Guanosine Triphosphate; D009132:Muscles; D009709:Nucleotide Deaminases; D010171:Palmitoyl Coenzyme A; D011188:Potassium; D011487:Protein Conformation | Biochimica et biophysica acta | 1,983 | D010171:Palmitoyl Coenzyme A; D000244:Adenosine Diphosphate; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D009709:Nucleotide Deaminases; D000659:AMP Deaminase; D011188:Potassium |
Patch-voltage-clamp method for measuring fast inward current in single rat heart muscle cells. | A patch-voltage-clamp method was used to measure fast inward ionic currents in single heart muscle cells. 1. Theoretical analysis including computer simulation has shown that the method provides fast settling of membrane potential (within 10 microseconds) and reliable voltage clamp on the tested membrane patch when the... | 10.1007/BF00582917 | 6,289,259 | D000818:Animals; D004594:Electrophysiology; D006321:Heart; D066298:In Vitro Techniques; D007473:Ion Channels; D008564:Membrane Potentials; D051381:Rats; D013997:Time Factors | Pflugers Archiv : European journal of physiology | 1,982 | D007473:Ion Channels |
Rock inhibition promotes NaV1.5 sodium channel-dependent SW620 colon cancer cell invasiveness. | The acquisition of invasive capacities by carcinoma cells, i.e. their ability to migrate through and to remodel extracellular matrices, is a determinant process leading to their dissemination and to the development of metastases. these cancer cell properties have often been associated with an increased Rho-ROCK signall... | 10.1038/s41598-020-70378-3 | 32,770,034 | D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000577:Amides; D045744:Cell Line, Tumor; D002465:Cell Movement; D003110:Colonic Neoplasms; D006801:Humans; D062554:NAV1.5 Voltage-Gated Sodium Channel; D009361:Neoplasm Invasiveness; D017346:Protein Serine-Threonine Kinases; D011725:Pyridines; D015398:Signal Trans... | Scientific reports | 2,020 | D000577:Amides; D062554:NAV1.5 Voltage-Gated Sodium Channel; D011725:Pyridines; C108830:Y 27632; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D017346:Protein Serine-Threonine Kinases; C049347:fasudil |
Genetic and phenotypic strain heterogeneity within a natural population of Oenococcus oeni from Amarone wine. | AIMS
To investigate the Oenococcus oeni population occurring during spontaneous malolactic fermentation (MLF) of Amarone wine, a peculiar and hostile environment for malolactic bacteria.
METHODS AND RESULTS
Pulsed-field gel electrophoresis (PFGE) analysis showed a high level of genetic heterogeneity within the O. oen... | 10.1111/j.1365-2672.2012.05425.x | 22,897,221 | D044822:Biodiversity; D004269:DNA, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D004952:Esters; D005285:Fermentation; D005798:Genes, Bacterial; D006027:Glycosides; D019344:Lactic Acid; D008293:Malates; D056585:Oenococcus; D010641:Phenotype; D011134:Polysaccharides; D013312:Stress, Physiological; D014920:Wine | Journal of applied microbiology | 2,012 | D004269:DNA, Bacterial; D004952:Esters; D006027:Glycosides; D008293:Malates; D011134:Polysaccharides; D019344:Lactic Acid; C030298:malic acid |
Update From the Advisory Committee on Immunization Practices. | The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group usually has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control... | 10.1093/jpids/piz045 | 31,367,738 | D000293:Adolescent; D000328:Adult; D026683:Advisory Committees; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007114:Immunization; D007115:Immunization Schedule; D007223:Infant; D008297:Male; D008875:Middle Aged; D010372:Pediatrics; D017410:Practice Guidelines as Topic; D012955... | Journal of the Pediatric Infectious Diseases Society | 2,019 | D014612:Vaccines; D017778:Vaccines, Combined |
Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression. | The oncogenic role of WNT is well characterized. Wntless (WLS) (also known as GPR177, or Evi), a key modulator of WNT protein secretion, was recently found to be highly overexpressed in malignant astrocytomas. We hypothesized that this molecule may be aberrantly expressed in other cancers known to possess aberrant WNT ... | 10.1038/modpathol.2014.114 | 25,258,105 | D001943:Breast Neoplasms; D002277:Carcinoma; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D053208:Kaplan-Meier Estimate; D008297:Male; D010051:Ovarian Neoplasms; D018719:Receptor, ErbB-2; D043562:Receptors, G-Protein-Coupled; D013274:Stomach Neopla... | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc | 2,015 | D047908:Intracellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled; C549111:WLS protein, human; C508053:ERBB2 protein, human; D018719:Receptor, ErbB-2 |
Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system. | PURPOSE
To evaluate the spectrum of activity of three beta-lactamase inhibitors such as amoxicillin/ clavulanic acid, ticarcillin/ clavulanic acid and piperacillin/ tazobactam in comparison to cephalosporins against gram negative bacilli.
METHODS
Gram-negative bacilli isolated from the clinical specimens received in ... | 10.4103/0255-0857.34759 | 17,901,635 | D000150:Acinetobacter; D000658:Amoxicillin; D019818:Clavulanic Acid; D004755:Enterobacteriaceae; D004791:Enzyme Inhibitors; D006090:Gram-Negative Bacteria; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid; D010878:Piperacillin; D011549:Pseudomonas; D020588:Stenotrophomonas; D000078142:Tazobactam; D013982:... | Indian journal of medical microbiology | 2,007 | D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; D019818:Clavulanic Acid; D000658:Amoxicillin; D010397:Penicillanic Acid; D013982:Ticarcillin; D000078142:Tazobactam; D010878:Piperacillin |
Genotyping for polymorphic drug metabolizing enzymes from paraffin-embedded and immunohistochemically stained tumor samples. | OBJECTIVES
Paraffin-embedded tumor samples are valuable in the study of cancer for routine staging, tumor marker analysis, and in retrospective studies to test new prognostic and predictive biomarkers. Their utility in retrospective pharmacogenetic analysis of clinical trials has yet to be evaluated. We set out to esta... | 10.1097/00008571-200308000-00008 | 12,893,988 | D001483:Base Sequence; D003577:Cytochrome P-450 Enzyme System; D017931:DNA Primers; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D009369:Neoplasms; D016612:Paraffin Embedding; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length | Pharmacogenetics | 2,003 | D017931:DNA Primers; D003577:Cytochrome P-450 Enzyme System |
Effects of insular stimulation on thermal nociception. | BACKGROUND
Electrical stimulation used for brain mapping in the postero-superior insula can evoke pain. The effects of prolonged high frequency insular stimulation on pain thresholds are unknown.
OBJECTIVE/HYPOTHESIS
Prolonged high frequency insular stimulation, by virtue of its inhibitory properties on networks, cou... | 10.1002/ejp.806 | 26,471,114 | D000328:Adult; D001921:Brain; D001931:Brain Mapping; D002540:Cerebral Cortex; D003080:Cold Temperature; D004311:Double-Blind Method; D004558:Electric Stimulation; D000069280:Electrocorticography; D004827:Epilepsy; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male;... | European journal of pain (London, England) | 2,016 | |
[Incidence and Risk Assessment of Tumor Lysis Syndrome in Patients with Advanced Germ Cell Cancer]. | Tumor lysis syndrome (TLS) is a major oncological emergency. TLS is common in patients with hematological malignancies, but it can occur across a spectrum of cancer types. Germ cell tumors (GCT) have rapid cancer cell turnover and often present with bulky metastasis. The international TLS expert consensus panel has rec... | 27,320,114 | D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal; D012189:Retrospective Studies; D018570:Risk Assessment; D018239:Seminoma; D013736:Testicular Neoplasms; D015275:Tumor Lysis Syndrome; D014503:Urate Oxidase; D055815:Young Adult | Hinyokika kiyo. Acta urologica Japonica | 2,016 | C469709:rasburicase; D014503:Urate Oxidase | |
Keratoacanthoma recurrent after surgical excision. | A 62-year-old man developed a recurrent keratoacanthoma within two and a half weeks after grossly and microscopically complete removal of the primary tumor. X-irradiation of the recurrent lesion caused partial regression, and then intralesional injections of a suspension of triamicinolone caused final resolution of it.... | 10.1111/j.1524-4725.1978.tb00489.x | 670,527 | D006801:Humans; D007636:Keratoacanthoma; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012871:Skin Diseases; D014221:Triamcinolone | The Journal of dermatologic surgery and oncology | 1,978 | D014221:Triamcinolone |
Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. | MC9 mast cells stimulated by a soluble (calcium ionophore A23187) or by an Fc epsilon-receptor agonist (IgE plus hapten) produce platelet activating factor (PAF). MC9 cells incorporate either exogenous [3H]acetic acid or [3H]lyso-PAF into PAF. PAF was identified by mobility on thin layer chromatography, platelet aggreg... | 10.1016/0006-291x(87)91444-6 | 3,107,564 | D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D000001:Calcimycin; D002460:Cell Line; D006241:Haptens; D007073:Immunoglobulin E; D008407:Mast Cells; D010972:Platelet Activating Factor; D010974:Platelet Aggregation; D011817:Rabbits; D011961:Receptors, Fc; D014316:Tritium | Biochemical and biophysical research communications | 1,987 | D000085:Acetates; D006241:Haptens; C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D011961:Receptors, Fc; D014316:Tritium; D007073:Immunoglobulin E; D000001:Calcimycin; D019342:Acetic Acid |
Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs. | Cytochrome P450 CYP2D6 is the most extensively characterized polymorphic drug-metabolizing enzyme. A deficiency of the CYP2D6 enzyme is inherited as an autosomal recessive trait; these subjects (7% of Caucasians, about 1% of Orientals) are classified as poor metabolizers. Among the rest (extensive metabolizers), enzyme... | 10.1046/j.0306-5251.2001.01548.x | 11,851,634 | D000483:Alleles; D019389:Cytochrome P-450 CYP2D6; D005784:Gene Amplification; D020440:Gene Duplication; D006801:Humans; D011110:Polymorphism, Genetic; D011619:Psychotropic Drugs | British journal of clinical pharmacology | 2,002 | D011619:Psychotropic Drugs; D019389:Cytochrome P-450 CYP2D6 |
Ganoderin A, a novel 9,11-secosterol from Ganoderma lucidum spores oil. | In this study, four sterols were isolated from the Ganoderma lucidum spores oil obtained via supercritical CO2 extraction. Four chemical constituents were ganoderin A (1), chaxine B (2), ergosterol, (3) and stellasterol (4). All the separated ingredients were characterized using spectral data interpretation and by comp... | 10.1080/10286020.2017.1313834 | 28,414,246 | D004875:Ergosterol; D032902:Ganoderma; D013172:Spores, Fungal; D013261:Sterols | Journal of Asian natural products research | 2,017 | D013261:Sterols; C000625249:chaxine B; C000625248:ganoderin A; C000625250:stellasterol; D004875:Ergosterol |
Implementation of MISSION-Criminal Justice in a Treatment Court: Preliminary Outcomes Among Individuals With Co-occurring Disorders. | OBJECTIVE
Mental health courts provide an alternative to incarceration and address both mental health and criminal justice needs. Many individuals within these treatment courts also have co-occurring substance use disorders. This pilot study examined the preliminary effectiveness of Maintaining Independence and Sobriet... | 10.1176/appi.ps.201800570 | 31,337,322 | D000328:Adult; D003156:Community Mental Health Services; D003416:Criminal Law; D057237:Criminals; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D006801:Humans; D008297:Male; D008404:Massachusetts; D001523:Mental Disorders; D008875:Middle Aged; D010865:Pilot Projects; D012307:Risk Factors; D019966:Substance-Rela... | Psychiatric services (Washington, D.C.) | 2,019 | |
Supragastric belching: Pathogenesis, diagnostic issues and treatment. | Belching is defined as an audible escape of air from the esophagus or the stomach into the pharynx. It becomes pathologic if it is excessive and becomes bothersome. According to Rome IV diagnostic criteria, there is a belching disorder when one experiences bothersome belching (severe enough to impact on usual activitie... | 10.4103/sjg.sjg_405_21 | 35,562,166 | D017097:Electric Impedance; D004884:Eructation; D005764:Gastroesophageal Reflux; D006801:Humans; D008365:Manometry; D013270:Stomach | Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association | 2,022 | |
Effects of oily fish and its fatty acid intake on non-alcoholic fatty liver disease development among South Korean adults. | Background
The benefits of fish fatty acid intake for non-alcoholic fatty liver disease (NAFLD) are rarely reported, although a previous study assessed the relationship between oily fish consumption and the prevalence of NAFLD.
Aims
We investigated whether oily fish and fish-based monounsaturated fatty acids, polyuns... | 10.3389/fnut.2022.876909 | 35,938,102 | Frontiers in nutrition | 2,022 | ||
DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import. | Transcription factor IRF3-mediated type I interferon induction plays a role in antiviral innate immunity. However, mechanisms for the control and regulation of IRF3 nuclear import remain largely unknown. We have identified DEAD box polypeptide 56 (DDX56) as a negative regulator of virus-triggered IFN-β induction. Overe... | 10.1242/jcs.230409 | 31,340,999 | D021581:Active Transport, Cell Nucleus; D002467:Cell Nucleus; D053487:DEAD-box RNA Helicases; D055786:Gene Knockout Techniques; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D007113:Immunity, Innate; D050838:Interferon Regulatory Factor-3; D016899:Interferon-beta; D010766:Phosphorylation; D017346:Protein Se... | Journal of cell science | 2,019 | C107940:IPO5 protein, human; C494232:IRF3 protein, human; D050838:Interferon Regulatory Factor-3; D028961:beta Karyopherins; D016899:Interferon-beta; D017346:Protein Serine-Threonine Kinases; C410330:DDX56 protein, human; D053487:DEAD-box RNA Helicases |
Randomized controlled trial of preoperative oral carbohydrate treatment in major abdominal surgery. | BACKGROUND
Major surgery is associated with postoperative insulin resistance which is attenuated by preoperative carbohydrate (CHO) treatment. The effect of this treatment on clinical outcome after major abdominal surgery has not been assessed in a double-blind randomized trial.
METHODS
Patients undergoing elective c... | 10.1002/bjs.7026 | 20,205,227 | D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D002097:C-Reactive Protein; D002241:Carbohydrates; D003108:Colonic Diseases; D004311:Double-Blind Method; D005221:Fatigue; D005260:Female; D018737:Hand Strength; D006801:Humans; D006854:Hydrocortisone; D007328:I... | The British journal of surgery | 2,010 | D001786:Blood Glucose; D002241:Carbohydrates; D007328:Insulin; D002097:C-Reactive Protein; D006854:Hydrocortisone |
Renal impairment after liver transplantation - a pilot trial of calcineurin inhibitor-free vs. calcineurin inhibitor sparing immunosuppression in patients with mildly impaired renal function after liver transplantation. | OBJECTIVES
Chronic kidney disease is frequent in patients after orthotopic liver transplantation (OLT) and has impact on survival. Patients receiving calcineurin inhibitors (CNI) are at increased risk to develop impaired renal function. Early CNI reduction and concomitant use of mycophenolat mofetil (MMF) has been show... | 10.1186/2047-783x-14-5-210 | 19,541,578 | D000410:Alanine Transaminase; D065095:Calcineurin Inhibitors; D003404:Creatinine; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors; D005260:Female; D005919:Glomerular Filtration Rate; D005938:Glucocorticoids; D006801:Humans; D007165:Immunosuppression Therapy; D00766... | European journal of medical research | 2,009 | D065095:Calcineurin Inhibitors; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D003404:Creatinine; D000410:Alanine Transaminase; D009173:Mycophenolic Acid; D011241:Prednisone |
Effect of Two- Versus Three-Way Split Resistance Training Routines on Body Composition and Muscular Strength in Bodybuilders: A Pilot Study. | The purpose of this study was to compare different split resistance training routines on body composition and muscular strength in elite bodybuilders. Ten male bodybuilders (26.7 ± 2.7 years, 85.3 ± 10.4 kg) were randomly assigned into one of two resistance training groups: 4 and 6 times per week (G4× and G6×, respecti... | 10.1123/ijsnem.2015-0077 | 26,008,801 | D015502:Absorptiometry, Photon; D001823:Body Composition; D004032:Diet; D006801:Humans; D008297:Male; D053580:Muscle Strength; D055070:Resistance Training; D014891:Weight Lifting | International journal of sport nutrition and exercise metabolism | 2,015 | |
Immunogenicity And Safety Of The 13-Valent Pneumococcal Conjugate Vaccine In Patients With Monoclonal Gammopathy Of Undetermined Significance - Relationship With Selected Immune And Clinical Parameters. | PURPOSE
Patients with monoclonal gammopathy of undetermined significance (MGUS) have an increased risk of developing infections. Streptococcus pneumoniae vaccinations are recommended for immunocompromised patients, including patients with lymphoproliferative disorders such as MGUS. The objective of the study was to ass... | 10.2147/CIA.S220423 | 31,631,993 | D000328:Adult; D016022:Case-Control Studies; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance; D009194:Myeloma Proteins; D011008:Pneumococcal Infections; D022242:Pneumococcal Vaccines; D018... | Clinical interventions in aging | 2,019 | C538862:13-valent pneumococcal vaccine; D007074:Immunoglobulin G; D009194:Myeloma Proteins; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate; C085016:multiple myeloma M-proteins |
Decoupling Control of Micromachined Spinning-Rotor Gyroscope with Electrostatic Suspension. | A micromachined gyroscope in which a high-speed spinning rotor is suspended electrostatically in a vacuum cavity usually functions as a dual-axis angular rate sensor. An inherent coupling error between the two sensing axes exists owing to the angular motion of the spinning rotor being controlled by a torque-rebalance l... | 27,775,624 | Sensors (Basel, Switzerland) | 2,016 | |||
The microbiomic and environmental analysis of sediments in the Indo-Pacific humpback dolphin (Sousa chinensis) habitat in the Northern Beibu Gulf, China. | The northern Beibu Gulf is one of the major habitats for the Indo-Pacific humpback dolphin (Sousa chinensis) in China. In this habitat, the core distribution zone of humpback dolphins was confined to the Sanniang Bay (SNB) and Dafengjiang River Estuary (DRE) areas. In our present research, the sediments of 14 sampling ... | 10.1007/s11356-018-3976-9 | 30,644,049 | D000818:Animals; D018533:Biomass; D002681:China; D004289:Dolphins; D017753:Ecosystem; D004784:Environmental Monitoring; D063366:Estuaries; D019015:Geologic Sediments; D019216:Metals, Heavy; D064307:Microbiota; D045483:Rivers; D014874:Water Pollutants, Chemical | Environmental science and pollution research international | 2,019 | D019216:Metals, Heavy; D014874:Water Pollutants, Chemical |
N-Glycosylated Ganoderma lucidum immunomodulatory protein improved anti-inflammatory activity via inhibition of the p38 MAPK pathway. | The global health emergency generated by coronavirus disease-2019 has prompted the search for immunomodulatory agents. There are many potential natural products for drug discovery and development to tackle this disease. One of these candidates is the Ganoderma lucidum fungal immunomodulatory protein (FIP-glu). In the p... | 10.1039/d1fo00178g | 33,900,328 | D000818:Animals; D015153:Blotting, Western; D002851:Chromatography, High Pressure Liquid; D016207:Cytokines; D004591:Electrophoresis, Polyacrylamide Gel; D005656:Fungal Proteins; D006023:Glycoproteins; D006031:Glycosylation; D007155:Immunologic Factors; D056747:Immunomodulation; D013058:Mass Spectrometry; D051379:Mice;... | Food & function | 2,021 | D016207:Cytokines; D005656:Fungal Proteins; D006023:Glycoproteins; D007155:Immunologic Factors; C061148:LZ-8 protein, Ganoderma lucidum; D048051:p38 Mitogen-Activated Protein Kinases; D043524:Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase |
An update on emerging drugs for Hodgkin lymphoma. | INTRODUCTION
Most patients with Hodgkin lymphoma (HL) are cured with modern combined modality first-line treatments. Even ~ 50% of patients with relapsed/refractory HL can be cured with high-dose chemotherapy (HDCT) and autologous stem cell transplantation. However, chemotherapy and radiotherapy cause significant acute... | 10.1517/14728214.2014.912277 | 24,749,769 | D000079963:Brentuximab Vedotin; D056572:Histone Deacetylase Inhibitors; D006689:Hodgkin Disease; D006801:Humans; D018796:Immunoconjugates; D053612:Janus Kinases; D000077269:Lenalidomide; D058570:TOR Serine-Threonine Kinases; D013792:Thalidomide | Expert opinion on emerging drugs | 2,014 | D056572:Histone Deacetylase Inhibitors; D018796:Immunoconjugates; D013792:Thalidomide; D000079963:Brentuximab Vedotin; D053612:Janus Kinases; D058570:TOR Serine-Threonine Kinases; D000077269:Lenalidomide |
Importance of genetic factors influencing the metabolism of foreign compounds. | Gene differences may alter an individual's response to foreign compounds by affecting their absorption, binding, distribution, excretion, biotransformation, or drug-drug interactions. Genetic differences in the metabolism of xenobiotics among inbred strains of various laboratory animals and model systems are reviewed. ... | 816,676 | D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000830:Animals, Laboratory; D001189:Aryl Hydrocarbon Hydroxylases; D001580:Benzopyrenes; D001711:Biotransformation; D004330:Drosophila; D004790:Enzyme Induction; D005799:Genes, Dominant; D005809:Genes, Regulator; D005838:Genotype; D008748:Methylcholanthrene; D... | Federation proceedings | 1,976 | D001580:Benzopyrenes; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D015049:Zoxazolamine; D010105:Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; D010634:Phenobarbital | |
Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates. | Starting from the pharmacophore model for HDAC inhibitor design, a novel series of hydroxamates bearing a uracil moiety as connecting unit (CU) has been prepared and tested. Almost all compounds exhibited HDAC inhibiting activity at low nanomolar concentrations, the N-hydroxy-6-(3,4-dihydro-4-oxo-6-benzyl- and -6-pheny... | 10.1016/j.bmcl.2005.07.081 | 16,165,353 | D000107:Acetylation; D000818:Animals; D000970:Antineoplastic Agents; D002454:Cell Differentiation; D049109:Cell Proliferation; D015195:Drug Design; D018922:HL-60 Cells; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D006801:Humans; D006877:Hydroxamic Acids; D051379:Mice; D008958:Models, Molecular; D041681:NI... | Bioorganic & medicinal chemistry letters | 2,005 | D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D006877:Hydroxamic Acids; D014498:Uracil |
[The cardiotocographic score of Hammacher in computer analysis]. | OBJECTIVE
After the quantitative, fully computerized evaluation of cardiotocography (CTG) after G.S. Dawes had yielded reliable results, an investigation was to be carried out to see whether a semiquantitative CTG analysis together with a CTG score (K. Hammacher) produced similarly useful results, too.
METHODS
The la... | 10.1159/000022324 | 10,867,492 | D000138:Acidosis; D015148:Cardiotocography; D003936:Diagnosis, Computer-Assisted; D005312:Fetal Blood; D005315:Fetal Diseases; D005318:Fetal Heart; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012984:Software | Gynakologisch-geburtshilfliche Rundschau | 2,000 | |
A micro method for simultaneous determination of galactosyltransferase and 5'-nucleotidase activities in cell fractions. | Galactosyltransferase and 5'-nucleotidase were assayed in the same reaction mixture, with ovalbumin as exogenous acceptor of (14-C)galactose and with (3-H)AMP as the substrate for the 5'-nucleotidase assay. The substrates and reaction products of either assay had no significant effect on the activity of the other enzym... | 10.1042/bj1460741 | 1,147,914 | D000249:Adenosine Monophosphate; D000818:Animals; D005690:Galactose; D006602:Hexosyltransferases; D007700:Kinetics; D008099:Liver; D008722:Methods; D009708:Nucleotidases; D010047:Ovalbumin; D051381:Rats; D013347:Subcellular Fractions | The Biochemical journal | 1,975 | D000249:Adenosine Monophosphate; D010047:Ovalbumin; D006602:Hexosyltransferases; D009708:Nucleotidases; D005690:Galactose |
Bone regeneration by using scaffold based on mineralized recombinant collagen. | Bone regeneration was achieved in the 15-mm segmental defect model in the radius of rabbit by using the scaffold based on mineralized recombinant collagen for the first time. The recombinant collagen was recombinant human-like type I collagen, which was produced by cloning a partial cDNA that was reversed by mRNA from ... | 10.1002/jbm.b.30984 | 18,161,820 | D000818:Animals; D032701:Biomimetics; D001861:Bone Regeneration; D003094:Collagen; D018076:DNA, Complementary; D017886:Durapatite; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures; D011108:Polymers; D012333:RNA, Messenger; D051381:Rats; D011994:Recombinant Proteins; D013818:Ther... | Journal of biomedical materials research. Part B, Applied biomaterials | 2,008 | D018076:DNA, Complementary; D011108:Polymers; D012333:RNA, Messenger; D011994:Recombinant Proteins; D003094:Collagen; D017886:Durapatite |
Biomarkers for stroke. | BACKGROUND
Major stroke clinical trials have failed during the past decades. The failures suggest the presence of heterogeneity among stroke patients. Biomarkers refer to indicators found in the blood, other body fluids or tissues that predicts physiologic or disease states, increased disease risk, or pharmacologic res... | 10.5853/jos.2013.15.1.27 | 24,324,937 | Journal of stroke | 2,013 | ||
Progressive, repeated lumbar compression fracture at the same level after vertebral kyphoplasty with calcium phosphate cement. Case report. | The authors report a case of vertebral body collapse after kyphoplasty in which calcium phosphate cement (CPC) was used. The patient, a 69-year-old woman in whom an L-1 compression fracture had been revealed on magnetic resonance imaging, had been treated at another regional hospital for the compressed vertebra. Kyphop... | 10.3171/spi.2007.6.6.7 | 17,561,745 | D000368:Aged; D001843:Bone Cements; D002130:Calcium Phosphates; D019299:Decompression, Surgical; D018450:Disease Progression; D005260:Female; D050815:Fractures, Compression; D006801:Humans; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures; D011859:Radiography; D012008:Recur... | Journal of neurosurgery. Spine | 2,007 | D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate |
Choosy males could help explain androdioecy in a selfing fish. | Androdioecy (the coexistence of males and hermaphrodites) is considered a transitional state derived from pure hermaphroditism or dioecy, but the processes selecting for this rare breeding system are unclear, particularly in animals. In androdioecious species, the proportion of males in relation to hermaphrodites is us... | 10.1086/670304 | 23,669,547 | D000818:Animals; D003532:Cyprinodontiformes; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D057850:Hermaphroditic Organisms; D008297:Male; D052586:Mating Preference, Animal; D012641:Selection, Genetic; D057945:Self-Fertilization | The American naturalist | 2,013 | |
Evaluation of Oxidative Stress Levels and Antioxidant Enzyme Activities in Burst Fractures. | BACKGROUND Spinal burst fractures are pathologies that occur in spinal injuries and cause significant mortality and morbidity as a result. Burst fractures in spinal cord injuries can result in rapid and significant oxidative stress. In addition to the primary injury in severe spinal cord injuries, subsequent secondary ... | 10.12659/msm.908312 | 29,324,724 | D000063:Accidents, Traffic; D000293:Adolescent; D000328:Adult; D000975:Antioxidants; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005978:Glutathione; D005979:Glutathione Peroxidase; D006801:Humans; D008297:Male; D008315:Malondialdehyde; D008875:Middle Aged; D018384:Oxidative Stress; D011182:Postop... | Medical science monitor : international medical journal of experimental and clinical research | 2,018 | D000975:Antioxidants; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione |
The therapeutic effects of naringenin on bronchial pneumonia in children. | Bronchial pneumonia in children is a common infectious disease in toddlers and infants, which may cause hyperpyrexia, pulmonary moist rales, and even respiratory failure. Traditional drugs for bronchial pneumonia in children often lead to drug resistance and side effects. Recently, naringenin has been reported to be a ... | 10.1002/prp2.825 | 34,310,866 | D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D017963:Azithromycin; D001996:Bronchopneumonia; D002675:Child, Preschool; D016207:Cytokines; D005260:Female; D044950:Flavanones; D006801:Humans; D007223:Infant; D008297:Male; D016896:Treatment Outcome | Pharmacology research & perspectives | 2,021 | D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D044950:Flavanones; D017963:Azithromycin; C005273:naringenin |
Glycoproteomic analysis of embryonic stem cells: identification of potential glycobiomarkers using lectin affinity chromatography of glycopeptides. | Numerous studies have recently focused on the identification of specific glycan biomarkers, given the important roles that protein linked glycans play, for example, during development and disease progression. The identification of protein glycobiomarkers, which are part of a very complex proteome, has involved the use ... | 10.1021/pr8007489 | 19,545,112 | D000595:Amino Acid Sequence; D000818:Animals; D015415:Biomarkers; D002478:Cells, Cultured; D002846:Chromatography, Affinity; D003208:Concanavalin A; D053595:Embryonic Stem Cells; D006023:Glycoproteins; D006031:Glycosylation; D051379:Mice; D008956:Models, Chemical; D008969:Molecular Sequence Data; D010446:Peptide Fragme... | Journal of proteome research | 2,010 | D015415:Biomarkers; D006023:Glycoproteins; D010446:Peptide Fragments; D003208:Concanavalin A; D014357:Trypsin |
Instructors for on-the-job training of advanced paramedics - definition of competencies and development of a quality management tool for a "High Responsibility Organization". | Objective: The psychological demands placed upon the emergency medical services, assures them of their place amongst High Responsibility Organizations. A high pressure to act and an irreversibility of situations are integral features of their workplaces. After the emergency services' job profiles were restructured in G... | 10.3205/zma001216 | 30,828,608 | D000488:Allied Health Personnel; D002983:Clinical Competence; D003697:Delphi Technique; D005178:Faculty; D005858:Germany; D006801:Humans; D007318:Inservice Training; D058996:Quality Improvement; D011795:Surveys and Questionnaires | GMS journal for medical education | 2,019 | |
Outcomes in Revision Stapes Surgery. | OBJECTIVES
To compare audiometric outcomes and complication rates between primary and revision stapes surgical cases.
STUDY DESIGN
Retrospective cohort study.
SETTING
Large single-institution database.
METHODS
Data on 809 patients (including 170 revisions) undergoing primary and revision stapes surgery were revie... | 10.1177/0194599821991479 | 33,560,173 | D000293:Adolescent; D000328:Adult; D001301:Audiometry, Pure-Tone; D001844:Bone Conduction; D005260:Female; D006099:Granuloma; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012086:Reoperation; D012189:Retrospective Studies; D013201:Stapes Surgery | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | 2,021 | |
Fractioned reaction time in power-trained and endurance-trained athletes under conditions of fatiguing isometric exercise. | Fractionated knee extensor and plantar flexor reaction time (RT) components were assessed in a group of eight weightlifters and eight long distance runners. Following a 4-day period of baseline stabilization for each muscle group, a 50% maximal voluntary contraction (MVC) holding-time exercise was administered. Results... | 10.1080/00222895.1981.10735242 | 15,201,126 | Journal of motor behavior | 1,981 | ||
Origin of the training effect and asymmetry of the magnetization in polycrystalline exchange bias systems. | The training effect and asymmetry in exchange-coupled polycrystalline CoO/Co bilayers with in-plane magnetization has been investigated. This system is selected for its large training effect and initial asymmetry of the magnetic hysteresis after field cooling, which is removed after training. Applying an in-plane magne... | 10.1103/PhysRevLett.99.067201 | 17,930,863 | Physical review letters | 2,007 | ||
A Posttranscriptional Pathway of CD40 Ligand mRNA Stability Is Required for the Development of an Optimal Humoral Immune Response. | CD40 ligand (CD40L) mRNA stability is dependent on an activation-induced pathway that is mediated by the binding complexes containing the multifunctional RNA-binding protein, polypyrimidine tract-binding protein 1 (PTBP1) to a 3' untranslated region of the transcript. To understand the relationship between regulated CD... | 10.4049/jimmunol.2001074 | 34,031,147 | D000818:Animals; D023201:CD40 Ligand; D056724:Immunity, Humoral; D051379:Mice; D008810:Mice, Inbred C57BL; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D012333:RNA, Messenger | Journal of immunology (Baltimore, Md. : 1950) | 2,021 | D012333:RNA, Messenger; D023201:CD40 Ligand |
Distal Ureteral Calculus or Deflux Calcification? | There have been >50,000 dextranomer-hyaluronic acid implants performed since 2001, and each has the potential to calcify. Although they are most often asymptomatic, these calcifications may mimic large distal ureteral calculi and are often misidentified on CT performed for suspected urolithiasis or other complaints. W... | 10.1089/cren.2019.0058 | 32,775,658 | Journal of endourology case reports | 2,019 | ||
A multi-centre quality improvement project to reduce the incidence of obstetric anal sphincter injury (OASI): study protocol. | BACKGROUND
Third and fourth degree perineal tears, or obstetric anal sphincter injuries (OASI), sustained during childbirth can result in anal incontinence and psychosocial problems which require ongoing treatment. Within the English National Health System (NHS) reported rates of OASI have gradually increased. In respo... | 10.1186/s12884-018-1965-0 | 30,103,734 | D001003:Anal Canal; D036861:Delivery, Obstetric; D004739:England; D004841:Episiotomy; D005242:Fecal Incontinence; D005260:Female; D006801:Humans; D000077626:Implementation Science; D015994:Incidence; D022125:Lacerations; D007744:Obstetric Labor Complications; D064872:Patient Care Bundles; D010353:Patient Education as T... | BMC pregnancy and childbirth | 2,018 | |
Enhancing Natural Reward Responsiveness Among Opioid Users Predicts Chronic Pain Relief: EEG Analyses From a Trial of Mindfulness-Oriented Recovery Enhancement. | OBJECTIVE
Although opioid-treated chronic pain patients evidence blunted responsiveness to natural rewards, focusing on naturally rewarding stimuli can produce analgesia in these patients. A prior randomized controlled trial (RCT) demonstrated that a social work intervention-Mindfulness-Oriented Recovery Enhancement (M... | 10.1086/697685 | 30,854,168 | Journal of the Society for Social Work and Research | 2,018 | ||
Hypoxia inducible factor-1α (HIF-1α) and some HIF-1 target genes are elevated in experimental glaucoma. | Low levels of hypoxia have been suggested to be a mechanism of retinal damage in glaucoma. To test the hypothesis that the activation of the hypoxia-responsive transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) is involved in the pathophysiology of glaucoma, we used a rat model of glaucoma to study (1) H... | 10.1007/s12031-010-9343-z | 20,237,864 | D000818:Animals; D001253:Astrocytes; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D005901:Glaucoma; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D012165:Retinal Ganglion Cells | Journal of molecular neuroscience : MN | 2,010 | C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit |
Single Versus Multiple Daily Dosing Regimens of Psychotropic Drugs for Psychiatric Disorders: A Systematic Review and Meta-Analysis. | OBJECTIVE
To compare efficacy and safety of single daily dosing (Single-DD) vs multiple daily dosing (Multiple-DD) regimens of psychotropic drugs, the authors conducted a systematic review and meta-analysis.
DATA SOURCES
A systematic literature search of MEDLINE and Embase was conducted with keywords related to dosin... | 33,988,935 | D004334:Drug Administration Schedule; D006801:Humans; D001523:Mental Disorders; D011619:Psychotropic Drugs; D016896:Treatment Outcome | The Journal of clinical psychiatry | 2,021 | D011619:Psychotropic Drugs | |
Utility and Prognostic Ability of a Diagnostic Injection Before Revision Total Knee Arthroplasty. | BACKGROUND
Diagnostic injections are commonly utilized in the workup of painful total knee arthroplasties (TKA), particularly when the diagnosis remains unclear. However, current literature provides limited evidence regarding the utility and prognostic capability of anesthetic injections in this scenario. This study so... | 10.1016/j.arth.2020.12.056 | 33,518,360 | D019645:Arthroplasty, Replacement, Knee; D006801:Humans; D007719:Knee Joint; D007720:Knee Prosthesis; D011379:Prognosis; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome | The Journal of arthroplasty | 2,021 | |
Behavior and neurocognitive performance in children aged 5-10 years who snore compared to controls. | Sleep disordered breathing in children is a common but largely underdiagnosed problem. It ranges in severity from primary snoring to obstructive sleep apnea syndrome (OSAS). Preliminary evidence suggests that children with severe OSAS show reduced neurocognitive performance, however, less is known about children who sn... | 10.1076/1380-3395(200010)22:5;1-9;FT554 | 11,094,391 | D000704:Analysis of Variance; D001288:Attention; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002652:Child Behavior; D002675:Child, Preschool; D003071:Cognition; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D01728... | Journal of clinical and experimental neuropsychology | 2,000 | |
Erectile dysfunction after robot-assisted radical prostatectomy. | With younger and healthier men being diagnosed and treated for localized prostate cancer, postradical prostatectomy erectile dysfunction has become an ever more important matter of debate. However, the lack of a standardized definition for potency and no consensus regarding the optimal instrument for assessing recovery... | 10.1586/era.10.16 | 20,470,006 | D000818:Animals; D007172:Erectile Dysfunction; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D011468:Prostatectomy; D011471:Prostatic Neoplasms; D012371:Robotics | Expert review of anticancer therapy | 2,010 | |
Sequencing a Strawberry Germplasm Collection Reveals New Viral Genetic Diversity and the Basis for New RT-qPCR Assays. | Viruses are considered of major importance in strawberry (Fragaria × ananassa Duchesne) production given their negative impact on plant vigor and growth. Strawberry accessions from the National Clonal Germplasm Repository were screened for viruses using high throughput sequencing (HTS). Analyses of sequence information... | 10.3390/v13081442 | 34,452,308 | D002874:Chromosome Mapping; D031985:Fragaria; D014644:Genetic Variation; D016679:Genome, Viral; D059014:High-Throughput Nucleotide Sequencing; D056186:Metagenomics; D010802:Phylogeny; D010935:Plant Diseases; D012328:RNA Viruses; D015203:Reproducibility of Results; D020133:Reverse Transcriptase Polymerase Chain Reaction | Viruses | 2,021 | |
Higher conservation laws for coherent optical pulse propagation in an inhomogeneously broadened medium. | The description of coherent optical pulse propagation in terms of coupled Maxwell and Schroedinger- Bloch equations in slowly varying envelope approximation possesses conservation laws in addition to those of field energy and field momentum. Comparison with preliminary numerical results has shown that these higher cons... | 10.1364/AO.11.002572 | 20,119,374 | Applied optics | 1,972 | ||
Subclinical and clinical atherosclerosis in non-alcoholic fatty liver disease is associated with the presence of hypertension. | BACKGROUND AND AIMS
Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular (CV) risk. However, it is unclear whether NAFLD contributes independently to the development of CV disease. Our study aimed at assessing the differences in several indices of atherosclerosis, arterial stiffness and... | 10.1016/j.numecd.2022.08.005 | 36,404,479 | D006801:Humans; D008297:Male; D000328:Adult; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D020257:Ventricular Remodeling; D050197:Atherosclerosis; D058226:Plaque, Atherosclerotic; D006973:Hypertension | Nutrition, metabolism, and cardiovascular diseases : NMCD | 2,022 | |
The Role and Potential Regulatory Mechanism of STING Modulated Macrophage Apoptosis and Differentiation in Severe Acute Pancreatitis-Associated Lung Injury. | This study aims to investigate the role of STING in promoting macrophage apoptosis and regulating macrophage polarization in severe acute pancreatitis (SAP)-associated lung injury in vitro and in vivo. A murine model was established by intraperitoneal injection of caerulein and lipopolysaccharide (LPS). Meanwhile, ANA-... | 10.1089/jir.2023.0077 | 37,819,622 | D051379:Mice; D000818:Animals; D010195:Pancreatitis; D008070:Lipopolysaccharides; D000208:Acute Disease; D055371:Acute Lung Injury; D008264:Macrophages; D017209:Apoptosis; D002454:Cell Differentiation | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research | 2,023 | D008070:Lipopolysaccharides |
Sexual Health During Postgraduate Training-European Survey Across Medical Specialties. | BACKGROUND
Sexual health problems are common. Therefore, training in sexual health is relevant for the clinical practice of trainees and early-career specialists in several specialties who deal with patients with sexual health problems. However, little is known about how sexual health training is provided across countr... | 10.1016/j.esxm.2018.04.001 | 29,706,561 | Sexual medicine | 2,018 | ||
The effects of chronotype on sexual satisfaction and quality of life in couples. | OBJECTIVE
Physiological, psychological, and behavioral variables are under circadian regularity audit in humans. Chronotype describes an individual's time preference regarding mental/physical endeavors and represents the circadian rhythm's physiological expressions. This study aimed to investigate the effects of couple... | 10.26355/eurrev_202210_30002 | 36,314,303 | D000328:Adult; D006801:Humans; D005260:Female; D008297:Male; D011788:Quality of Life; D011795:Surveys and Questionnaires; D012725:Sexual Behavior; D002940:Circadian Rhythm; D012890:Sleep | European review for medical and pharmacological sciences | 2,022 | |
Discriminative Video Representation Learning Using Support Vector Classifiers. | Most popular deep models for action recognition in videos generate independent predictions for short clips, which are then pooled heuristically to assign an action label to the full video segment. As not all frames may characterize the underlying action-indeed, many are common across multiple actions-pooling schemes th... | 10.1109/TPAMI.2019.2937292 | 31,449,006 | IEEE transactions on pattern analysis and machine intelligence | 2,021 | ||
[The influence of antiretroviral-resistance tests on treatment effectiveness in patients with HIV and virological failure]. | OBJECTIVE
The objective of this study is to determine the influence of antiretroviral-resistance tests on the suppression of HIV (< 400 copies/mL) in patients with virological failure who require an alternative antiretroviral treatment.
METHOD
A retrospective observational study on cohorts of adult patients. Two grou... | 10.1016/s1130-6343(07)75707-0 | 17,439,310 | D000328:Adult; D044966:Anti-Retroviral Agents; D015704:CD4 Antigens; D015331:Cohort Studies; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections; D006801:Humans; D008297:Male; D010600:Pharmacology; D012189:Retrospective Studies; D017211:Treatment Failure | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria | 2,007 | D044966:Anti-Retroviral Agents; D015704:CD4 Antigens |
Assessment of susceptibility of low-density lipoprotein to oxidation. | It is now recognized that oxidation of low-density lipoprotein (LDL) is a key event in the development of atherosclerosis (1). In vivo, oxidation is believed to occur primarily in the arterial wall. In early atherosclerotic lesions oxidation may be initiated by enzymes, including myeloperoxidase and 15-lipoxygenase, or... | 10.1385/1-59259-070-5:199 | 22,351,276 | Methods in molecular medicine | 2,000 | ||
Isocyanate vapor-induced antigenicity of human albumin. | BACKGROUND
The bioreactivity of isocyanate, a leading cause of occupational asthma, has led to uncertainty regarding the chemical's antigenicity and mechanisms that elicit immunopathology.
OBJECTIVE
To understand better the biologically relevant antigenic forms of hexamethylene diisocyanate (HDI), commonly used in th... | 10.1016/j.jaci.2004.03.009 | 15,208,602 | D000418:Albumins; D001249:Asthma; D003485:Cyanates; D005782:Gels; D006801:Humans; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D017953:Isocyanates; D016273:Occupational Exposure; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014835:Volatilization | The Journal of allergy and clinical immunology | 2,004 | D000418:Albumins; D003485:Cyanates; D005782:Gels; D007074:Immunoglobulin G; D017953:Isocyanates; C015262:1,6-hexamethylene diisocyanate; D007073:Immunoglobulin E |
Use of corticosteroids in oral surgery. | Perioperative use of corticosteroids has been advocated for reduction of pain, edema, and trismus following oral surgical procedures. Clinical trials involving the use of corticosteroids in oral surgery are reviewed with emphasis on the following points: 1) the type of procedure; 2) the specific regimen and its relativ... | 10.1016/0278-2391(92)90325-t | 1,542,068 | D000305:Adrenal Cortex Hormones; D001623:Betamethasone; D016009:Chi-Square Distribution; D002986:Clinical Trials as Topic; D003907:Dexamethasone; D004487:Edema; D006801:Humans; D008775:Methylprednisolone; D008964:Molar, Third; D010149:Pain, Postoperative; D011239:Prednisolone; D011292:Premedication; D013515:Surgery, Or... | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | 1,992 | D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D001623:Betamethasone; D011239:Prednisolone; D008775:Methylprednisolone |
Automated nanoflow liquid chromatography/tandem mass spectrometric identification of proteins from Shewanella putrefaciens separated by two-dimensional polyacrylamide gel electrophoresis. | The implementation of nanoflow liquid chromatography offers unique opportunities for automation of proteomics research. We demonstrate that automated nanoflow LC/MS/MS allowed the unambiguous identification of proteins from the omnipotent bacterium Shewanella putrefaciens, based on similarity searches against the compl... | 10.1002/1097-0231(20010115)15:1<50::AID-RCM191>3.0.CO;2-V | 11,135,424 | D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D002851:Chromatography, High Pressure Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D010446:Peptide Fragments; D020614:Shewanella putrefaciens | Rapid communications in mass spectrometry : RCM | 2,001 | D001426:Bacterial Proteins; D010446:Peptide Fragments |
Major Changes in Head and Neck Staging for 2018. | Oncologists should be aware of three major modifications and additions to staging head and neck cancer that became effective in 2018. Oral cavity cancers have the addition of depth of invasion; oropharyngeal cancers (OPCs) are now distinguished by the immunohistochemical stain, p16, into those that are associated with ... | 10.1200/EDBK_199697 | 30,231,400 | D001706:Biopsy; D019468:Disease Management; D006258:Head and Neck Neoplasms; D006801:Humans; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D030361:Papillomavirus Infections; D017410:Practice Guidelines as Topic; D011379:Prognosis; D047368:Tumor Burden | American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting | 2,018 | |
Pharmacokinetics of midazolam and its major metabolite 1-hydroxymidazolam in the ball python (Python regius) after intracardiac and intramuscular administrations. | Midazolam is a benzodiazepine with sedative, muscle relaxant, anxiolytic, and anticonvulsant effects. Twelve ball pythons (Python regius) were used in a parallel study evaluating the pharmacokinetics of 1Â mg/kg midazolam following a single intracardiac (IC) or intramuscular (IM) administration. Blood was collected from... | 10.1111/jvp.12806 | 31,469,454 | D000818:Animals; D019540:Area Under Curve; D017821:Boidae; D062905:Central Venous Catheters; D006207:Half-Life; D006993:Hypnotics and Sedatives; D007273:Injections, Intramuscular; D008874:Midazolam | Journal of veterinary pharmacology and therapeutics | 2,019 | D006993:Hypnotics and Sedatives; C040081:1-hydroxymethylmidazolam; D008874:Midazolam |
Hypothalamic interconnections of somatostatin and growth hormone releasing factor neurons. | Combined immunohistochemical labelling for neurons containing growth hormone (GH) releasing factor (GRF) or somatostatin and single labelling immunohistochemistry combined with Fluorogold retrograde transport labelling were used to examine whether somatostatin or GRF neurons might be reciprocally innervated. Occasional... | 10.1159/000125285 | 2,575,237 | D000818:Animals; D007025:Anterior Hypothalamic Nucleus; D001111:Arcuate Nucleus of Hypothalamus; D005456:Fluorescent Dyes; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D007031:Hypothalamus; D007150:Immunohistochemistry; D008297:Male; D008473:Median Eminence; D009434:Neural Pathways; D009474:Neurons... | Neuroendocrinology | 1,989 | C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D013266:Stilbamidines; D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone |
Crystallization and preliminary X-ray crystallographic analysis of acetohydroxy acid isomeroreductase from Pseudomonas aeruginosa. | Acetohydroxy acid isomeroreductase (AHIR) is involved in the biosynthetic pathway of branched-chain amino acids in microorganisms and plants. AHIR from Pseudomonas aeruginosa has been overexpressed in Escherichia coli and crystallized at 297 K using potassium/sodium tartrate as a precipitant. X-ray diffraction data hav... | 10.1107/s0907444902015573 | 12,454,481 | D000429:Alcohol Oxidoreductases; D003460:Crystallization; D018360:Crystallography, X-Ray; D050540:Ketol-Acid Reductoisomerase; D008027:Light; D011487:Protein Conformation; D011550:Pseudomonas aeruginosa; D011994:Recombinant Proteins; D012542:Scattering, Radiation | Acta crystallographica. Section D, Biological crystallography | 2,002 | D011994:Recombinant Proteins; D000429:Alcohol Oxidoreductases; D050540:Ketol-Acid Reductoisomerase |
Flow resistance in carotid and middle cerebral arteries in postmenopausal women: a comparative study of tibolone and continuous combined hormone replacement therapy. | OBJECTIVE
The study sought to compare the vascular resistance and serum lipids of postmenopausal women assigned to tibolone therapy or continuous combined hormone replacement therapy.
DESIGN
This was a 6-month, prospective, single-blind, single-center, randomized study. A total of 50 healthy postmenopausal women were... | 12,419,084 | D001783:Blood Flow Velocity; D001921:Brain; D017536:Carotid Artery, Common; D002343:Carotid Artery, Internal; D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003326:Coronary Circulation; D004334:Drug Administration Schedule; D020847:Estrogen Receptor Modulators; D015914:Estrogen Replacement Th... | Climacteric : the journal of the International Menopause Society | 2,002 | D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D020847:Estrogen Receptor Modulators; D004966:Estrogens, Conjugated (USP); D009652:Norpregnenes; D014280:Triglycerides; D002784:Cholesterol; D017258:Medroxyprogesterone Acetate; C027385:tibolone | |
Observations on pathological and histochemical changes in piglet livers infected with Taenia saginata asiatica. | To study the pathological and histochemical characteristics of lesions in piglet livers infected with Taenia saginata asiatica (T. saginata asiatica) throughout the different stages, piglets were fed with eggs of T. saginata asiatica and raised in isolation in an animal center to establish the T. saginata asiatica infe... | 10.1007/s11684-007-0049-8 | 24,573,862 | Frontiers of medicine in China | 2,007 | ||
Bulk Fabrication of WS2 Nanoplates: Investigation on the Morphology Evolution and Electrochemical Performance. | Two-dimensional layered chalcogenide WS2, similar to graphene, is considered to be very interesting for materials scientists. However, to make it a useful material platform, it is necessary to develop sophisticated synthesis methods to control its morphology. In this paper, we present a simple approach to prepare vario... | 10.1021/acsami.6b04601 | 27,295,215 | ACS applied materials & interfaces | 2,016 | ||
NimbleMiner: A Novel Multi-Lingual Text Mining Application. | This demonstration showcase will present a novel open access text mining application called NimbleMiner. NimbleMiner's architecture is language agnostic and it can be potentially applied in multiple languages. The system was applied in a series of recent studies in several languages, including English and Hebrew. The s... | 10.3233/SHTI190558 | 31,438,255 | D057225:Data Mining; D007802:Language; D009323:Natural Language Processing | Studies in health technology and informatics | 2,019 | |
Validation of a functional screening instrument for dementia in an elderly sri lankan population: comparison of modified bristol and blessed activities of daily living scales. | BACKGROUND
Cognitive tests have been used in population surveys as first stage screens for dementia but are biased by education. However functional ability scales are less biased by education than the cognitive scale and thus can be used in screening for dementia.
OBJECTIVE
To validate Activities of Daily Living (ADL... | 10.1186/1756-0500-3-268 | 20,974,013 | BMC research notes | 2,010 | ||
Neighborhood perceptions and allostatic load: Evidence from Midlife in the United States study. | Allostatic load, which represents the cumulative wear and tear on physiological systems resulting from long-term exposure to stress, provides a theoretical framework that can be applied to understand the association between neighborhood conditions and health outcomes. Within allostatic load theory perception plays a ke... | 10.1016/j.healthplace.2019.102263 | 32,329,729 | D052636:Allostasis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010465:Perception; D012111:Residence Characteristics; D013315:Stress, Psychological; D014481:United States | Health & place | 2,020 | |
Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines. | Hypoxia and inflammation are frequently co-incidental features of the tissue microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on inflammatory pathways in immune cells has been well characterized, less is known about how inflammatory stimuli such as cytokines impact upon the canonic... | 10.3390/cells10092340 | 34,571,989 | D016207:Cytokines; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007249:Inflammation; D053583:Interleukin-1beta; D012333:RNA, Messenger; D015398:Signal Transduction; D015533:Transcript... | Cells | 2,021 | D016207:Cytokines; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C508585:IL1B protein, human; D053583:Interleukin-1beta; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha |
Relationship of obesity with serum concentrations of leptin, CRP and IL-6 in breast cancer survivors. | INTRODUCTION
Several mechanisms have been proposed to explain the adverse effect of obesity on quality of life among women with breast cancer, including alteration in some inflammatory markers. The aim of this study was to determine the status of serum levels of leptin, IL-6 and CRP in obese, overweight and normal weig... | 26,462,194 | D000328:Adult; D015415:Biomarkers; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms; D002097:C-Reactive Protein; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D018836:Inflammation Mediators; D015850:Interleukin-6; D020738:Leptin; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm S... | Journal of the Egyptian National Cancer Institute | 2,015 | D015415:Biomarkers; D014408:Biomarkers, Tumor; D018836:Inflammation Mediators; D015850:Interleukin-6; D020738:Leptin; D002097:C-Reactive Protein | |
Segmental strain analysis for the detection of chronic ischemic scars in non-contrast cardiac MRI cine images. | Cardiac magnetic resonance imaging (MRI) with late gadolinium enhancement (LGE) is considered the gold standard for scar detection after myocardial infarction. In times of increasing skepticism about gadolinium depositions in brain tissue and contraindications of gadolinium administration in some patient groups, tissue... | 10.1038/s41598-021-90283-7 | 34,117,271 | D000328:Adult; D000368:Aged; D002921:Cicatrix; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia | Scientific reports | 2,021 | |
Haptic quantum chemistry. | We present an implementation designed to physically experience quantum mechanical forces between reactants in chemical reactions. This allows one to screen the profile of potential energy surfaces for the study of reaction mechanisms. For this, we have developed a interface between the user and a virtual laboratory by ... | 10.1002/jcc.21201 | 19,130,501 | Journal of computational chemistry | 2,009 | ||
Pneumopericardium and pneumomediastinum following closed chest injury. | Pneumopericardium and pneumomediastinum following closed chest injury are rare findings, especially when symptoms are delayed for several days and are not associated with other related traumatic entities. A case is presented of a 14-year-old boy who developed symptoms of precordial chest pains and splinting two days af... | 10.1016/s0361-1124(79)80407-4 | 491,330 | D000293:Adolescent; D006801:Humans; D008297:Male; D008478:Mediastinal Emphysema; D011026:Pneumopericardium; D011859:Radiography; D013898:Thoracic Injuries | JACEP | 1,979 | |
[Extracorporeal shock wave lithotripsy of sialoliths as a new noninvasive outpatient treatment concept]. | The rapid progression of Extracorporeal Shock Wave Lithotripsy (ESWL) opens new possibilities in painless non-invasive treatment of salivary gland stones under local therapy. Procedure and first very promising success in the clinical appliance to sialolithiasis is shown as follows. | 2,102,435 | D006801:Humans; D008096:Lithotripsy; D010305:Parotid Diseases; D015494:Salivary Gland Calculi; D013364:Submandibular Gland Diseases | Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie | 1,990 | ||
A Comparative Study of Liver Disease Care in the USA and Urban and Rural China. | BACKGROUND
Chronic liver disease is a major cause of morbidity and mortality in the USA and China, but the etiology of liver disease, medical practice, and patient expectations in these two countries are different.
AIMS
To compare patient knowledge about their liver disease, patient satisfaction with liver disease ca... | 10.1007/s10620-016-4206-2 | 27,256,156 | D000328:Adult; D000368:Aged; D002681:China; D002908:Chronic Disease; D003657:Decision Making; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D019694:Hepatitis B, Chronic; D019698:Hepatitis C, Chronic; D019693:Hepatitis, Autoimmune; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic; D008107:Liver Diseas... | Digestive diseases and sciences | 2,016 | |
Morphology, Vibratory Function, and Vascular Pattern for Predicting Malignancy in Vocal Fold Leukoplakia. | BACKGROUND
The study evaluates clinical features of vocal fold (VF) leukoplakia in predicting its benign or malignant nature.
MATERIALS
57 patients with 84 lesions were evaluated before undergoing laryngeal microsurgery. The texture, color, thickness and size of the leukoplakia, along with an assessment of the surrou... | 10.1016/j.jvoice.2019.04.001 | 31,006,608 | D006801:Humans; D006965:Hyperplasia; D007822:Laryngeal Neoplasms; D007971:Leukoplakia; D062048:Narrow Band Imaging; D014827:Vocal Cords | Journal of voice : official journal of the Voice Foundation | 2,020 | |
Porphyria cutanea tarda and melioidosis. | Porphyria cutanea tarda is a metabolic disorder in the haem biosynthetic pathway. It includes a heterogeneous group of conditions, which may be inherited or, more commonly, acquired. Although porphyria cutanea tarda presents with cutaneous lesions only, it is often associated with systemic disease. A 64-year-old Chines... | 11,514,757 | D000900:Anti-Bacterial Agents; D005260:Female; D006801:Humans; D019190:Iron Overload; D008554:Melioidosis; D008875:Middle Aged; D017119:Porphyria Cutanea Tarda | Hong Kong medical journal = Xianggang yi xue za zhi | 2,001 | D000900:Anti-Bacterial Agents | |
Coagulation profile in patients with H1N1 influenza A infection undergoing treatment for haematological malignancies. | Patients with haematological malignancies receiving concurrent treatment or after allogeneic stem cell transplantation (HSCT) are considered to be at increased risk for acquiring influenza A (H1N1) infection (pH1N1) and influenza-associated complications leading to increased mortality. We report of a series of haematol... | 10.1097/MBC.0000000000000139 | 24,824,490 | D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents; D015415:Biomarkers; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D005260:Female; D019337:Hematologic Neoplasms; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human; D... | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis | 2,014 | D000970:Antineoplastic Agents; D015415:Biomarkers |
Musculoskeletal injuries associated with earthquake. A report of injuries of Iran's December 26, 2003 Bam earthquake casualties managed in tertiary referral centers. | This is a descriptive analysis, performed on victims of Iran's December 26, 2003 Bam earthquake that were referred to tertiary referral trauma management centre in Tehran. Two hundred and ten patients were included in this study. Associated musculoskeletal injuries and renal function of the patients were recorded. The ... | 10.1016/j.injury.2004.06.021 | 15,589,909 | D058186:Acute Kidney Injury; D000293:Adolescent; D000328:Adult; D000368:Aged; D001134:Arm Injuries; D002648:Child; D003161:Compartment Syndromes; D006259:Craniocerebral Trauma; D004190:Disasters; D005260:Female; D050723:Fractures, Bone; D006801:Humans; D015994:Incidence; D007492:Iran; D007869:Leg Injuries; D008297:Male... | Injury | 2,005 | |
Development of simultaneous partial nitrification, anammox and denitrification (SNAD) process in a sequential batch reactor. | Simultaneous partial nitrification, anammox and denitrification (SNAD) process was developed in a sequential batch reactor (SBR) and the influence of hydraulic retention time (HRT) on the SNAD process was investigated. Around 96% NH(4)(+)-N removal and 87% COD removal were observed at 9 d HRT. Marginal decreases in the... | 10.1016/j.biortech.2010.11.024 | 21,123,056 | D000693:Anaerobiosis; D057919:Biological Oxygen Demand Analysis; D019149:Bioreactors; D058440:Denitrification; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D058465:Nitrification; D010084:Oxidation-Reduction; D010100:Oxygen; D000644:Quaternary Ammonium Compounds; D012995:Solubility; D013997:Time Factors... | Bioresource technology | 2,011 | D000644:Quaternary Ammonium Compounds; D010100:Oxygen |
Strategies for treating mitochondrial disorders: an update. | Mitochondrial diseases are a heterogeneous group of disorders resulting from primary dysfunction of the respiratory chain due to both nuclear and mitochondrial DNA mutations. The wide heterogeneity of biochemical dysfunctions and pathogenic mechanisms typical of this group of diseases has hindered therapy trials; there... | 25,458,518 | D002118:Calcium; D004272:DNA, Mitochondrial; D004579:Electron Transport; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria; D028361:Mitochondrial Diseases; D063269:Mitochondrial Turnover; D017382:Reactive Oxygen Species | Molecular genetics and metabolism | 2,014 | D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species; D002118:Calcium |
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