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Are eye movement abnormalities indicators of genetic vulnerability to schizophrenia? | UNLABELLED
Fifty to eighty-five percent of schizophrenic patients are impaired on ocular pursuit paradigms. However, results regarding the relatives are more discordant. The aim of this study was to investigate whether eye movement disorders could be a vulnerability marker of schizophrenia.
METHOD
Twenty-one schizoph... | 10.1016/j.eurpsy.2004.12.010 | 16,018,927 | D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015835:Ocular Motility Disorders; D011698:Pursuit, Smooth; D012018:Reflex; D012438:Saccades; D012559:Schizophrenia | European psychiatry : the journal of the Association of European Psychiatrists | 2,005 | D005819:Genetic Markers |
Bayesian factorizations of big sparse tensors. | It has become routine to collect data that are structured as multiway arrays (tensors). There is an enormous literature on low rank and sparse matrix factorizations, but limited consideration of extensions to the tensor case in statistics. The most common low rank tensor factorization relies on parallel factor analysis... | 10.1080/01621459.2014.983233 | 31,210,707 | Journal of the American Statistical Association | 2,015 | ||
Enhanced desorption of cesium from collapsed interlayer regions in vermiculite by hydrothermal treatment with divalent cations. | Adsorption of cesium (Cs) on phyllosilicates has been intensively investigated because natural soils have strong ability of immobilizing Cs within clay minerals resulting in difficulty of decontamination. The objectives of present study are to clarify how Cs fixation on vermiculite is influenced by structure change cau... | 10.1016/j.jhazmat.2016.12.017 | 27,987,449 | Journal of hazardous materials | 2,017 | ||
Chemical Characterization of Atlantic Cod (Gadus morhua) Collagen Hydrolyzed Using Enzyme Preparation Derived from Red King Crab (Paralithodes camtschaticus) and Its Potential as a Core Component of Bacterial Culture Medium. | The Atlantic cod (Gadus morhua) and red king crab (Paralithodes camtschaticus) processing wastes are massive and unutilized in the Murmansk region of Russia. The samples of skin-containing waste of Atlantic cod fillets production were hydrolyzed using enzyme preparations derived from red king crab hepatopancreases, por... | 10.3390/md19080472 | 34,436,311 | D000818:Animals; D059001:Aquatic Organisms; D002688:Chitinases; D003094:Collagen; D003445:Crustacea; D003470:Culture Media; D048389:Gadus morhua; D006868:Hydrolysis; D012426:Russia | Marine drugs | 2,021 | D003470:Culture Media; D003094:Collagen; D002688:Chitinases |
A type 1 DNA topoisomerase from the kinetoplast hemoflagellate Leishmania donovani. | A type 1 DNA topoisomerase has been purified from the nuclei of the kinetoplast hemoflagellate Leishmania donovani using polyethylene glycol fractionation and chromatography on hydroxylapatite, phosphocellulose and phenylsepharose column. The relaxation activity is ATP independent. Mg2+ is an essential cofactor for the... | 8,144,168 | D000818:Animals; D002467:Cell Nucleus; D002845:Chromatography; D002852:Chromatography, Ion Exchange; D004264:DNA Topoisomerases, Type I; D018105:DNA, Kinetoplast; D017886:Durapatite; D007700:Kinetics; D007893:Leishmania donovani; D011092:Polyethylene Glycols | Indian journal of biochemistry & biophysics | 1,993 | D018105:DNA, Kinetoplast; D011092:Polyethylene Glycols; D017886:Durapatite; D004264:DNA Topoisomerases, Type I | |
Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation. | BACKGROUND & AIMS
Fecal microbiota transplantation (FMT) is an emerging treatment modality for ulcerative colitis (UC). Several randomized controlled trials have shown efficacy for FMT in the treatment of UC, but a better understanding of the transferable microbiota and their immune impact is needed to develop more eff... | 10.1053/j.gastro.2021.09.061 | 34,606,847 | D000818:Animals; D041963:Bacteroidetes; D002986:Clinical Trials as Topic; D003092:Colitis; D003093:Colitis, Ulcerative; D003106:Colon; D004195:Disease Models, Animal; D000069467:Fecal Microbiota Transplantation; D051858:Forkhead Transcription Factors; D000069196:Gastrointestinal Microbiome; D005856:Germ-Free Life; D006... | Gastroenterology | 2,022 | D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D007070:Immunoglobulin A; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539901:Rorc protein, mouse |
Role of Inflammatory/Immune Response and Cytokine Polymorphisms in the Severity of Chronic Hepatitis C (CHC) before and after Direct Acting Antiviral (DAAs) Treatment. | Host regulatory immune response is involved in the hepatic inflammatory process caused by the hepatitis C virus (HCV). We aimed to determine if HCV clearance with direct-acting antivirals (DAAs) changes the hepatic fibrosis stage, biochemical parameters of liver injury, and inflammatory/immune responses. Sample: 329 ch... | 10.3390/ijms24021380 | 36,674,897 | D006801:Humans; D000998:Antiviral Agents; D016207:Cytokines; D019698:Hepatitis C, Chronic; D016753:Interleukin-10; D014409:Tumor Necrosis Factor-alpha; D011110:Polymorphism, Genetic; D008103:Liver Cirrhosis; D006526:Hepatitis C; D016212:Transforming Growth Factor beta; D016174:Hepacivirus; D007109:Immunity | International journal of molecular sciences | 2,023 | D000998:Antiviral Agents; D016207:Cytokines; D016753:Interleukin-10; D014409:Tumor Necrosis Factor-alpha; D016212:Transforming Growth Factor beta |
Childhood overweight, obesity and associated factors among primary school children in dire dawa, eastern Ethiopia; a cross-sectional study. | BACKGROUND
Obesity in children is increasing worldwide. Malnutrition has become a double burden challenge of public health concern in developing countries. Childhood obesity increases the risk of chronic disease in childhood as well as adulthood. However, information is very scarce about childhood obesity in developing... | 10.1186/s40608-017-0156-2 | 28,572,983 | BMC obesity | 2,017 | ||
Characterization of duck leucocytes by monoclonal antibodies. | cDNAs encoding CD3epsilon, CD4 and the alpha-chain of CD8 of ducks were cloned. Monoclonal antibodies against Pekin duck CD4 and CD8alpha revealed that the antigens were expressed by the majority of thymocytes and by subpopulations of CD3+ cells in peripheral tissues. CD8alpha cell surface expression was also found on ... | 10.1016/j.dci.2005.01.001 | 15,854,685 | D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D001402:B-Lymphocytes; D015415:Biomarkers; D001792:Blood Platelets; D002060:Bursa of Fabricius; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D002454:Cell Differentiation; D003001:Cloning, Molecular; D... | Developmental and comparative immunology | 2,005 | D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015415:Biomarkers; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens |
Chagas Cardiomyopathy Presenting as Symptomatic Bradycardia: An Underappreciated Emerging Public Health Problem in the United States. | Chagas cardiomyopathy (CCM) is traditionally considered a disease restricted to areas of endemicity. However, an estimated 300,000 people living in the United States today have CCM, of which its majority is undiagnosed. We present a case of CCM acquired in an endemic area and detected in its early stage. A 42-year-old ... | 10.1155/2017/5728742 | 28,900,547 | Case reports in cardiology | 2,017 | ||
Comparing Insetting Techniques When Using the Vascularized Fibula Flap for Extremity Oncologic Defect Reconstruction in the Pediatric Population. | BACKGROUND
Extremity reconstruction in skeletally immature patients presents unique challenges in terms of operative technique, bone healing, and limb function. A variety of insetting techniques have been described, with no clearly superior option. We hypothesized that vascularized fibula flaps placed in the intramedul... | 10.1097/PRS.0000000000010613 | 37,166,051 | Plastic and reconstructive surgery | 2,023 | ||
A meta-analysis of responses in floral traits and flower-visitor interactions to water deficit. | Alterations in water availability and drought events as predicted by climate change scenarios will increasingly impact natural communities with effects already emerging at present. Water deficit leads to increasing physiological stress in plants, likely affecting floral development and causing changes in floral morphol... | 10.1111/gcb.15621 | 33,774,883 | D035264:Flowers; D057048:Plant Nectar; D011058:Pollen; D054817:Pollination; D014867:Water | Global change biology | 2,021 | D057048:Plant Nectar; D014867:Water |
Normal postprandial nonesterified fatty acid uptake in muscles despite increased circulating fatty acids in type 2 diabetes. | OBJECTIVE
Postprandial plasma nonesterified fatty acid (NEFA) appearance is increased in type 2 diabetes. Our objective was to determine whether skeletal muscle uptake of plasma NEFA is abnormal during the postprandial state in type 2 diabetes.
RESEARCH DESIGN AND METHODS
Thigh muscle blood flow and oxidative metabol... | 10.2337/db10-0997 | 21,228,312 | D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2; D005230:Fatty Acids, Nonesterified; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal; D019518:Postprandial Period; D013848:Thigh | Diabetes | 2,011 | D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified |
Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin. | Human leukocyte antigen DQ2 is a class II major histocompatibility complex protein that plays a critical role in the pathogenesis of Celiac Sprue by binding to epitopes derived from dietary gluten and triggering the inflammatory response of disease-specific T cells. Inhibition of DQ2-mediated antigen presentation in th... | 10.1021/ja056423o | 16,464,085 | D000595:Amino Acid Sequence; D017951:Antigen Presentation; D005903:Gliadin; D006683:HLA-DQ Antigens; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D010446:Peptide Fragments; D011485:Protein Binding; D013329:Structure-Activity Relationship | Journal of the American Chemical Society | 2,006 | D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D010446:Peptide Fragments; D005903:Gliadin |
SARS-CoV-2 infections among Australian passengers on the Diamond Princess cruise ship: A retrospective cohort study. | BACKGROUND
Prolonged periods of confined living on a cruise ship increase the risk for respiratory disease transmission. We describe the epidemiology and clinical characteristics of a SARS-CoV-2 outbreak in Australian passengers on the Diamond Princess cruise ship and provide recommendations to mitigate future cruise s... | 10.1371/journal.pone.0255401 | 34,492,022 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia; D000086382:COVID-19; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D008297:Male; D008875:Middle Aged; D011790:Quara... | PloS one | 2,021 | |
Early and late recurrence after liver resection for hepatocellular carcinoma: prognostic and therapeutic implications. | OBJECTIVE
To evaluate the predictive factors, the therapy, and the prognosis of intrahepatic recurrence (IR) after surgery for hepatocellular carcinoma (HCC).
SUMMARY BACKGROUND DATA
The predictive factors of IR are debated. To class the recurrence according to the modality of presentation may help to find a correlat... | 10.1097/01.sla.0000197706.21803.a1 | 16,432,356 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular; D016009:Chi-Square Distribution; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D01... | Annals of surgery | 2,006 | |
[Alkalosis]. | An elevation of arterial blood pH called alkalosis remains an underestimated condition in hospitalized patients. Serious alkalosis can be associated with high risk of death. The disorder can be caused by increased concentration of bicarbonate (metabolic alkalosis) or decreased concentration of carbon dioxide (respirato... | 24,490,489 | D000471:Alkalosis; D000472:Alkalosis, Respiratory; D001639:Bicarbonates; D002245:Carbon Dioxide; D003937:Diagnosis, Differential; D004232:Diuretics; D006801:Humans; D006985:Hyperventilation; D009422:Nervous System Diseases; D014839:Vomiting | Wiadomosci lekarskie (Warsaw, Poland : 1960) | 2,013 | D001639:Bicarbonates; D004232:Diuretics; D002245:Carbon Dioxide | |
A role for viral infections in Parkinson's etiology? | Despite over 200 years since its first description by James Parkinson, the cause(s) of most cases of Parkinson's disease (PD) are yet to be elucidated. The disparity between the current understanding of PD symptomology and pathology has led to numerous symptomatic therapies, but no strategy for prevention or disease cu... | 10.1042/NS20170166 | 32,714,585 | Neuronal signaling | 2,018 | ||
Functional amygdala-hippocampus connectivity during anticipation of aversive events is associated with Gray's trait "sensitivity to punishment". | BACKGROUND
The reinforcement sensitivity theory postulates a behavioral inhibition system that modulates reaction to stimuli indicating aversive events. Gray's dimension of anxiety, reflecting human trait sensitivity to aversive events, determines the extent to which stimuli activate the behavioral inhibition system. A... | 10.1016/j.biopsych.2010.04.033 | 20,542,494 | D000293:Adolescent; D000328:Adult; D000679:Amygdala; D059031:Anticipation, Psychological; D005260:Female; D006624:Hippocampus; D006801:Humans; D007266:Inhibition, Psychological; D008016:Life Change Events; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011589:Psychology, Experiment... | Biological psychiatry | 2,010 | |
Adaptive reorganization of 2D molecular nanoporous network induced by coadsorbed guest molecule. | The ordered array of nanovoids in nanoporous networks, such as honeycomb, Kagome, and square, provides a molecular template for the accommodation of "guest molecules". Compared with the commonly studied guest molecules featuring high symmetry evenly incorporated into the template, guest molecules featuring lower symmet... | 10.1021/la5002418 | 24,628,397 | Langmuir : the ACS journal of surfaces and colloids | 2,014 | ||
Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids. | The SARS-CoV-2 virus has caused already over 3.5 million COVID-19 cases and 250,000 deaths globally. There is an urgent need to create novel models to study SARS-CoV-2 using human disease-relevant cells to understand key features of virus biology and facilitate drug screening. As primary SARS-CoV-2 infection is respira... | 10.1101/2020.05.05.079095 | 32,511,403 | bioRxiv : the preprint server for biology | 2,020 | ||
The genetic mediation of individual differences in sensitivity to pain and its inhibition. | The underlying bases of the considerable interindividual variability in pain-related traits are starting to be revealed. Although the relative importance of genes versus experience in human pain perception remains unclear, rodent populations display large and heritable differences in both nociceptive and analgesic sens... | 10.1073/pnas.96.14.7744 | 10,393,892 | D000700:Analgesics; D000818:Animals; D003577:Cytochrome P-450 Enzyme System; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009619:Nociceptors; D010146:Pain; D051381:Rats; D011957:Receptors, Opioid | Proceedings of the National Academy of Sciences of the United States of America | 1,999 | D000700:Analgesics; D011957:Receptors, Opioid; D003577:Cytochrome P-450 Enzyme System |
Precision crystal corner cube arrays for optical gratings formed by (100) silicon planes with selective epitaxial growth. | High-quality, micrometer scale, corner cube arrays were grown on (111) silicon substrates by selective epitaxial growth (SEG) techniques. Sixteen different arrays were produced that had periodic corner spacing ranging from 3 to 50 µm. The arrays were formed by suppressing silicon SEG in a regular geometric pattern, pro... | 10.1364/AO.35.003466 | 21,102,736 | Applied optics | 1,996 | ||
Systematic review: the potential influence of mesalazine formulation on maintenance of remission in Crohn's disease. | AIM
To evaluate the effectiveness of pH 6-/pH 7-dependent and controlled-release mesalazines in maintaining medically and surgically induced Crohn's disease remission.
METHODS
A systematic search identified 13 randomized controlled trials (RCTs). The rate of symptomatic relapse (Crohn's disease activity index >150, o... | 10.1111/j.1365-2036.2007.03324.x | 17,539,978 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D003424:Crohn Disease; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D019804:Mesalamine; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D055502:Secondary Prevention; D016896:T... | Alimentary pharmacology & therapeutics | 2,007 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D019804:Mesalamine |
Comparison of Blood Oxygenation Level-Dependent fMRI and Provocative DSC Perfusion MR Imaging for Monitoring Cerebrovascular Reserve in Intracranial Chronic Cerebrovascular Disease. | BACKGROUND AND PURPOSE
Loss of hemodynamic reserve in intracranial cerebrovascular disease reduces blood oxygenation level-dependent activation by fMRI and increases asymmetry in MTT measured by provocative DSC perfusion MR imaging before and after vasodilation with intravenous acetazolamide. The concordance for detect... | 10.3174/ajnr.A5515 | 29,371,256 | D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders; D003097:Collateral Circulation; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging; D012189:Retrospective Studies | AJNR. American journal of neuroradiology | 2,018 | |
Evaluating the effectiveness of countywide mental health care systems. | This study evaluates the effectiveness of eight (four urban and four rural) Community Support Program (CSP) delivery systems located in a state in the northwest United States. Data were collected from 364 respondents: 156 service organization directors, 49 case managers, 77 family members, and 82 seriously mentally ill... | 10.1007/BF00752439 | 2,721,136 | D000328:Adult; D000368:Aged; D003156:Community Mental Health Services; D004812:Epidemiologic Methods; D005260:Female; D006301:Health Services Needs and Demand; D006302:Health Services Research; D006801:Humans; D008297:Male; D008875:Middle Aged; D015397:Program Evaluation; D011785:Quality Assurance, Health Care; D012424... | Community mental health journal | 1,989 | |
Pre-operative templating in total elbow arthroplasty: not useful. | PURPOSE
Total elbow arthroplasty (TEA) is a definitive surgical procedure for treating rheumatoid arthritis and (posttraumatic) osteoarthritis of the elbow and is also useful in comminuted elbow fractures. Pre-operative digital templating may theoretically improve the surgical implantation of TEA, but reliability and p... | 10.1007/s00402-016-2444-6 | 26,980,096 | D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid; D057929:Arthroplasty, Replacement, Elbow; D004550:Elbow; D005260:Female; D005598:Fractures, Spontaneous; D006801:Humans; D006811:Humerus; D008875:Middle Aged; D015588:Observer Variation; D010003:Osteoarthritis; D011300:Preoperative Care; D011859:Ra... | Archives of orthopaedic and trauma surgery | 2,016 | |
Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121. | BACKGROUND
Adenovirus (Ad) vector-mediated gene therapy strategies have emerged as promising modalities for the "biological revascularization" of tissues. We hypothesized that direct intramyocardial, as opposed to intracoronary, administration of an Ad vector coding for the vascular endothelial growth factor 121 cDNA (... | 10.1016/s0003-4975(99)01102-9 | 10,654,479 | D000256:Adenoviridae; D000818:Animals; D003097:Collateral Circulation; D017023:Coronary Angiography; D003326:Coronary Circulation; D003331:Coronary Vessels; D004195:Disease Models, Animal; D016228:Endothelial Growth Factors; D015967:Gene Expression Regulation, Viral; D015316:Genetic Therapy; D005822:Genetic Vectors; D0... | The Annals of thoracic surgery | 2,000 | D016228:Endothelial Growth Factors; D008222:Lymphokines; D020033:Protein Isoforms; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors |
Epitope-specific suppression of antibody response in experimental autoimmune myasthenia gravis by a monomethoxypolyethylene glycol conjugate of a myasthenogenic synthetic peptide. | A synthetic peptide corresponding to a myasthenogenic region of Torpedo californica acetylcholine (AcCho) receptor (AcChoR) alpha subunit, AcChoR alpha-(125-148), was conjugated to monomethoxypolyethylene glycol (mPEG). Injection of mice with the mPEG-AcChoR alpha-(125-148) conjugate and subsequent immunization with wh... | 10.1073/pnas.89.13.5852 | 1,378,618 | D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D001323:Autoantibodies; D000939:Epitopes; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009157:Myasthenia Gravis; D01045... | Proceedings of the National Academy of Sciences of the United States of America | 1,992 | D001323:Autoantibodies; D000939:Epitopes; D010455:Peptides; D011978:Receptors, Nicotinic; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol |
Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness. | Human rhinoviruses (HRV) cause acute upper respiratory illness. The frequency of HRV-associated illnesses appears greater when PCR assays are used to detect rhinoviruses. The present study performed PCR-based detection of HRV upon entry of subjects into respiratory syncytial virus and parainfluenza type 3 vaccine trial... | 10.1128/JCM.02553-06 | 17,475,758 | D000328:Adult; D017677:Age Distribution; D002353:Carrier State; D002648:Child; D006801:Humans; D007223:Infant; D009296:Nasal Cavity; D010850:Picornaviridae Infections; D012140:Respiratory Tract Diseases; D012229:Rhinovirus | Journal of clinical microbiology | 2,007 | |
Gas pockets in a wastewater rising main: a case study. | This paper presents a case study of an existing wastewater rising main (WWRM) in which an extreme transient event produced by simultaneous power failure of the pumps caused the rupture of a 1.2 m (48 in) prestressed concrete cylinder pipe (PCCP), causing an important leakage of sewage. The event and the methodology fol... | 10.2166/wst.2012.462 | 22,949,261 | D003198:Computer Simulation; D004323:Drainage, Sanitary; D005740:Gases; D017058:Mexican Americans; D008800:Mexico; D008962:Models, Theoretical; D011312:Pressure; D012722:Sewage; D014865:Waste Disposal, Fluid | Water science and technology : a journal of the International Association on Water Pollution Research | 2,012 | D005740:Gases; D012722:Sewage |
Rate of hypotony and intraocular pressure fluctuation immediately after intravitreal dexamethasone implantation in vitrectomized eyes. | PURPOSE
To observe the rate of hypotony and intraocular pressure (IOP) fluctuations immediately following intravitreal dexamethasone implantation in vitrectomized eyes.
METHODS
The study included previously vitrectomized eyes scheduled to receive intravitreal dexamethasone implants. IOP measurements were performed at... | 10.1016/j.jfo.2019.07.023 | 31,952,876 | D000368:Aged; D003907:Dexamethasone; D004343:Drug Implants; D005128:Eye Diseases; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D015814:Ocular Hypotension; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D014821:Vitrectomy; D0... | Journal francais d'ophtalmologie | 2,020 | D004343:Drug Implants; D003907:Dexamethasone |
Quality Improvement in Mackerel Fillets Caused by Brine Salting Combined with High-Pressure Processing. | The purpose of the study is to investigate the effects of brine salting and high-pressure processing (HPP) on the microbial inactivation and quality parameters of mackerel fillets. Mackerel fillets were immersed in 3% and 9% sodium chloride brine for 90 min at refrigerator temperature, and then treated at 300, 400, 500... | 10.3390/biology11091307 | 36,138,786 | Biology | 2,022 | ||
Aging and human CD4(+) regulatory T cells. | Alterations in immunity that occur with aging likely contribute to the development of infection, malignancy and inflammatory diseases. Naturally occurring CD4(+) regulatory T cells (Treg) expressing high levels of CD25 and forkhead box P3 (FOXP3) are essential for regulating immune responses. Here we investigated the e... | 10.1016/j.mad.2009.06.003 | 19,540,259 | D000328:Adult; D000368:Aged; D000375:Aging; D015496:CD4-Positive T-Lymphocytes; D049109:Cell Proliferation; D016207:Cytokines; D005260:Female; D051858:Forkhead Transcription Factors; D006801:Humans; D007107:Immune System; D016753:Interleukin-10; D053645:Interleukin-2 Receptor alpha Subunit; D008297:Male; D010641:Phenot... | Mechanisms of ageing and development | 2,009 | D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit; D016753:Interleukin-10 |
Abatacept downregulates Fcγ receptor I on circulating monocytes: a potential therapeutic mechanism in patients with rheumatoid arthritis. | BACKGROUND
Abatacept is a recombinant fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte antigen 4 and the Fc portion of immunoglobulin (Ig) G. The mechanism of action of abatacept in rheumatoid arthritis (RA) is believed to be competitive inhibition of T cell costimulation mediated by the bi... | 10.1186/s13075-022-02886-8 | 35,964,055 | D000069594:Abatacept; D000936:Antigen-Antibody Complex; D001172:Arthritis, Rheumatoid; D001323:Autoantibodies; D016207:Cytokines; D006801:Humans; D007074:Immunoglobulin G; D009000:Monocytes; D017452:Receptors, IgG | Arthritis research & therapy | 2,022 | D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D016207:Cytokines; D007074:Immunoglobulin G; D017452:Receptors, IgG; D000069594:Abatacept |
[The use of Doppler echocardiography in the diagnosis of congenital heart disease in the Pediatric Department of CHU-Tokoin, at Lomé (Togo)]. | Currently, echography coupled with Doppler is a primary technique in the diagnosis of congenital heart disease. Since September 1993, the pediatric ward of the Tokoin teaching hospital of Lome has been equipped with this technology. During the following 23 months, there were 299 examinations with Doppler-echocardiograp... | 8,764,450 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003490:Cyanosis; D015150:Echocardiography, Doppler; D004694:Endocardial Cushion Defects; D005260:Female; D006330:Heart Defects, Congenital; D006337:Heart Murmurs; D006345:Heart Septal Defects, Ventricular; D006748:Hospital Departments; D006784:Hospitals, Tea... | Sante (Montrouge, France) | 1,996 | ||
Assessment of plaque vulnerability by angioscopic classification of plaque color. | BACKGROUND
The disruption of yellow plaque and subsequent thrombosis is regarded as the mechanism of acute coronary syndrome. However, there are limited reports on the assessment of plaque vulnerability. Therefore, we tested whether the angioscopically determined yellow color intensity of plaque is associated with the ... | 10.1016/j.ahj.2004.03.047 | 15,309,005 | D000368:Aged; D000704:Analysis of Variance; D017546:Angioscopy; D016009:Chi-Square Distribution; D003116:Color; D003324:Coronary Artery Disease; D003328:Coronary Thrombosis; D003331:Coronary Vessels; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged | American heart journal | 2,004 | |
[Preparation of a monoclonal antibodies against Plasmodium falciparum glutamate dehydrogenase and establishment of colloidal gold-immunochromatographic assay]. | OBJECTIVE
To prepare a monoclonal antibodies (mAbs) against glutamate dehydrogenase (GDH) of Plasmodium falciparum (FCC1/HN strain) and establish colloidal gold-immunochromatographic assay (GICA) for diagnosis of Plasmodium falciparum malaria.
METHODS
Recombinant GDH was used to immunize Balb/C mice and the mAbs agai... | 15,837,649 | D000818:Animals; D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005969:Glutamate Dehydrogenase; D017979:Gold Colloid; D007118:Immunoassay; D016778:Malaria, Falciparum; D051379:Mice; D008807:Mice, Inbred BALB C; D010963:Plasmodium falciparum | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA | 2,005 | D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D017979:Gold Colloid; D005969:Glutamate Dehydrogenase | |
Identifying technology interaction opportunities within a gastroenterology exam room. | Gastric cancer is a serious disease that most people usually do not know they have until they start to get symptoms. Gastroenterology imaging is an essential tool for this battle, since an early diagnosis typically leads to a good prognosis. However, this is a rapidly evolving technological area with novel imaging devi... | 25,991,229 | D005762:Gastroenterology; D005773:Gastroscopy; D006801:Humans; D017146:Models, Organizational; D011174:Portugal; D013274:Stomach Neoplasms; D013673:Technology Assessment, Biomedical; D014584:User-Computer Interface; D057188:Workflow; D016526:Workload | Studies in health technology and informatics | 2,015 | ||
Transarterial chemoembolization for hepatocellular carcinoma: significance of extrahepatic collateral supply. | PURPOSE
Transarterial chemoemblization (TACE) is the most common treatment modality for treating patients of large unresectable hepatocellular carcinoma (HCC). Extrahepatic collateral arterial supply (ECS) to these large tumors is not uncommon. This study was designed to assess the significance and outcome of TACE in p... | 10.4103/0019-509X.84941 | 21,921,335 | D001772:Blood Cell Count; D006528:Carcinoma, Hepatocellular; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin; D004317:Doxorubicin; D004998:Ethiodized Oil; D006801:Humans; D008099:Liver; D008113:Liver Neoplasms; D009367:Neoplasm Staging; D000509:alpha-Fetoproteins | Indian journal of cancer | 2,011 | D000509:alpha-Fetoproteins; D004998:Ethiodized Oil; D004317:Doxorubicin; D002945:Cisplatin |
Pd/Cu-catalyzed C-H arylation of 1,3,4-thiadiazoles with (hetero)aryl iodides, bromides, and triflates. | The direct C-H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl hal... | 10.1021/jo301401q | 22,957,511 | D001965:Bromides; D002384:Catalysis; D003300:Copper; D006846:Hydrocarbons, Halogenated; D006860:Hydrogen Bonding; D007454:Iodides; D015394:Molecular Structure; D010165:Palladium; D013830:Thiadiazoles | The Journal of organic chemistry | 2,012 | D001965:Bromides; D006846:Hydrocarbons, Halogenated; D007454:Iodides; D013830:Thiadiazoles; D010165:Palladium; D003300:Copper |
Severe Inflammatory Colitis Related to Encorafenib and Binimetinib following Immune Checkpoint Inhibitor Therapy. | Encorafenib, a BRAF kinase inhibitor, in combination with binimetinib, a selective MEK inhibitor have known gastrointestinal adverse events; however, adverse colitis events have not been well studied. We report a case series of 4 patients with melanoma who developed inflammatory colitis after BRAF and MEK inhibition wi... | 10.1159/000525012 | 35,949,237 | Case reports in gastroenterology | 2,022 | ||
'Smartscopy' as an alternative device for cervical cancer screening: a pilot study. | The use of smartphones, mobile networks and associated health applications (known as apps) is now almost universal. Countries with low medical resources need assistance in their delivery of healthcare. This is particularly true where there are limited numbers of specialised physicians or nurses with respect to cancer s... | 10.1136/bmjinnov-2016-000174 | 28,794,895 | BMJ innovations | 2,017 | ||
Antimicrobial susceptibility testing of Mycobacterium tuberculosis to first-line drugs: comparisons of the MGIT 960 and BACTEC 460 systems. | The reliability of the Mycobacteria Growth Indicator Tube (MGIT) 960 system for rapid antimicrobial susceptibility testing (AST) of Mycobacterium tuberculosis was evaluated. Forty-seven isolates, including 10 fully susceptible and 37 resistant strains, were tested for susceptibility to the critical concentrations of st... | 12,017,195 | D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis; D012293:Rifampin; D013307:Streptomycin; D014397:Tuberculosis, Pulmonary | Annals of clinical and laboratory science | 2,002 | D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin | |
Studies on the biotin-binding site of avidin. Lysine residues involved in the active site. | Egg-white avidin was treated with 1-fluoro-2,4-dinitrobenzene. Modification of an average of one lysine residue per avidin subunit caused the complete loss of biotin binding. Tryptic peptides obtained from the 2,4-dinitrophenylated avidin were fractionated by reversed-phase h.p.l.c. Three peptides contained the 2,4-din... | 10.1042/bj2420923 | 3,109,401 | D000596:Amino Acids; D001360:Avidin; D001665:Binding Sites; D001710:Biotin; D002851:Chromatography, High Pressure Liquid; D008239:Lysine; D010446:Peptide Fragments | The Biochemical journal | 1,987 | D000596:Amino Acids; D010446:Peptide Fragments; D001360:Avidin; D001710:Biotin; D008239:Lysine |
Release of S100B during coronary artery bypass grafting is reduced by off-pump surgery. | BACKGROUND
S100B, a plasma marker of brain injury, was compared after coronary artery bypass grafting with and without cardiopulmonary bypass (CPB).
METHODS
Fourteen patients with off-pump operations and 18 patients with CPB were compared. Seven patients in the off-pump group underwent a minithoracotomy and received ... | 10.1016/s0003-4975(99)00318-5 | 10,391,281 | D000368:Aged; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003327:Coronary Disease; D006801:Humans; D007118:Immunoassay; D008875:Middle Aged; D011446:Prospective Studies; D009418:S100 Proteins; D013249:Sternum; D013908:Thoracotomy | The Annals of thoracic surgery | 1,999 | D009418:S100 Proteins |
[A study of sensitization and symptoms in adult asthmatics who keep cat and dog]. | We studied hypersensitivity to cats and dogs in three hundred adult asthmatics who kept them. Some findings were noted as follows. 1) The mean duration for which cats were kept was 6.2 +/- 10.1 (1 S.D.) years and that for dogs was 4.2 +/- 9.6 (1 S.D.) years. 2) The positive rate in intradermal tests to dog dander was 7... | 8,347,088 | D000328:Adult; D000818:Animals; D000829:Animals, Domestic; D001249:Asthma; D002415:Cats; D004285:Dogs; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D013997:Time Factors | Arerugi = [Allergy] | 1,993 | ||
Levocetirizine: from scientific evidence to a potent modern-day treatment of today's allergic patients. | Increasing evidence suggests that most of today's allergic rhinitis patients are sensitized to more than one trigger, likely due to constant exposure to increased levels of traditional and new allergens from exotic foods and pets, resulting in manifestation of the more persistent and moderate/severe symptoms. The Aller... | 10.1358/dot.2009.45.3.1339920 | 19,436,843 | D017332:Cetirizine; D039563:Histamine H1 Antagonists, Non-Sedating; D006801:Humans; D006967:Hypersensitivity | Drugs of today (Barcelona, Spain : 1998) | 2,009 | D039563:Histamine H1 Antagonists, Non-Sedating; C472067:levocetirizine; D017332:Cetirizine |
Poisoning in the United States: 2012 emergency medicine report of the National Poison Data System. | Deaths from drug overdose have become the leading cause of injury death in the United States, where the poison center system is available to provide real-time advice and collect data about a variety of poisonings. In 2012, emergency medical providers were confronted with new poisonings, such as bath salts (substituted ... | 25,523,411 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000701:Analgesics, Opioid; D002648:Child; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D016208:Databases, Factual; D003666:Decontamination; D003902:Detergents; D004632:Emergency Medical Services; D006801:Humans; D011039:Poison Control Centers; D011041... | Annals of emergency medicine | 2,015 | D000701:Analgesics, Opioid; D003902:Detergents | |
Effect of Spherical Aberration on the Optical Quality after Implantation of Two Different Aspherical Intraocular Lenses. | PURPOSE
To compare the effect of spherical aberration on optical quality in eyes with two different aspherical intraocular lenses.
METHODS
120 eyes of 60 patients underwent phacoemulsification. In patients' eyes, an aberration-free IOL (Aspira-aA; Human Optics) or an aberration-correcting aspherical IOL (Tecnis ZCB00... | 10.1155/2017/8039719 | 28,900,544 | Journal of ophthalmology | 2,017 | ||
Antagonist muscle activity during human forearm movements under varying kinematic and loading conditions. | During the performance of unidirectional, single-joint movements it is known that muscle activation is not confined to the agonist, but is generally seen in the antagonist as well, appearing as a burst of antagonist activity if the movement is quite rapid. We have studied the integral over time of antagonist electromyo... | 10.1007/BF00248559 | 3,622,697 | D000293:Adolescent; D000328:Adult; D004576:Electromyography; D005542:Forearm; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009043:Motor Activity; D009132:Muscles; D011601:Psychophysics | Experimental brain research | 1,987 | |
Surgical removal of subfoveal choroidal neovascular membranes in high myopia. | BACKGROUND
A study was carried out to elucidate the anatomical and functional outcome after surgical excision of subfoveal choroidal neovascular membranes in high myopia.
METHODS
Sixty-five patients with high myopia (> or =6 diopters), well-defined subfoveal neovascular membranes on fluorescein angiography and preope... | 10.1007/s004170050281 | 10,424,308 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid; D020256:Choroidal Neovascularization; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005584:Fovea Centralis; D006801:Humans; D008297:Male; D008566:Membranes; D008875:Middle Aged; D009216:Myopia; D0... | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie | 1,999 | |
The Osteogenic Potential of Brown Seaweed Extracts. | Marine drugs hold significantly more promise than their terrestrial counterparts, which could help to solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone th... | 10.3390/md17030141 | 30,823,356 | D044646:Ascophyllum; D002454:Cell Differentiation; D002460:Cell Line; D049109:Cell Proliferation; D016166:Free Radical Scavengers; D006801:Humans; D007795:Laminaria; D059630:Mesenchymal Stem Cells; D010006:Osteoblasts; D010012:Osteogenesis; D010936:Plant Extracts; D061251:Primary Cell Culture; D012624:Seaweed; D024341:... | Marine drugs | 2,019 | D016166:Free Radical Scavengers; D010936:Plant Extracts; D024341:Xanthophylls; C025164:fucoxanthin |
An oxidant- and organic solvent-resistant alkaline metalloprotease from Streptomyces olivochromogenes. | Organic solvent- and detergent-resistant proteases are important from an industrial viewpoint. However, they have been less frequently reported and only few of them are from actinomycetes. A metalloprotease from Streptomyces olivochromogenes (SOMP) was purified by ion exchange with Poros HQ and gel filtration with Seph... | 10.1007/s12010-010-8925-0 | 20,195,792 | D000468:Alkalies; D002850:Chromatography, Gel; D003902:Detergents; D004591:Electrophoresis, Polyacrylamide Gel; D004795:Enzyme Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D045726:Metalloproteases; D008670:Metals; D008970:Molecular Weight; D009930:Organic Chemicals; D016877:Oxidants; D011480:Proteas... | Applied biochemistry and biotechnology | 2,010 | D000468:Alkalies; D003902:Detergents; D008670:Metals; D009930:Organic Chemicals; D016877:Oxidants; D011480:Protease Inhibitors; D019163:Reducing Agents; D012997:Solvents; D045726:Metalloproteases |
Monitoring and improving the effectiveness of cleaning medical and surgical devices. | The overall risk of infection from medical devices is very low, but high infection transmission rates have been related to inadequate reprocessing of arthroscopic shavers and flexible duodenoscopes. Monitoring of manual and automated cleaning is needed to ensure that inadequately cleaned medical devices are recleaned p... | 23,622,750 | D020679:Arthroscopes; D003428:Cross Infection; D020698:Duodenoscopes; D004866:Equipment Contamination; D017743:Equipment Reuse; D006801:Humans; D013242:Sterilization; D013525:Surgical Instruments | American journal of infection control | 2,013 | ||
High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11). | In a family with a high incidence of postmenopausal breast cancer and a case of glioblastoma, the constitutional translocation t(11;22)(q23;q11.2) was shown to segregate with the malignancies. The breakpoints in this family coincided with the common breakpoints in t(11;22) as shown by a translocation-specific PCR assay... | 10.1002/gcc.20358 | 16,845,657 | D000328:Adult; D000368:Aged; D001932:Brain Neoplasms; D001943:Breast Neoplasms; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015994:Incidence; D008297:Male; D008875:Middl... | Genes, chromosomes & cancer | 2,006 | |
Human beta cells are exceedingly resistant to streptozotocin in vivo. | Streptozotocin (STZ) causes beta cell death in rodents via the mechanism of DNA damage precipitating poly(ADP-ribose) synthetase activation followed by lethal nicotinamide adenine dinucleotide depletion. It is unclear whether humans are susceptible to this mechanism. Islets were isolated from STZ-sensitive (CD1 mice an... | 10.1210/endo.143.7.8901 | 12,072,379 | D000818:Animals; D003921:Diabetes Mellitus, Experimental; D004351:Drug Resistance; D005951:Glucose Tolerance Test; D006801:Humans; D007515:Islets of Langerhans; D016381:Islets of Langerhans Transplantation; D008297:Male; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D011917:Rats, Inbred Lew; D013045:Species Specifici... | Endocrinology | 2,002 | D013311:Streptozocin |
What Caused My Cancer? Cancer Patients' Perceptions on What May Have Contributed to the Development of Their Cancer: A Cross-Sectional, Cross-Country Comparison Study. | Accurate public perceptions on the risk factors associated with cancer are important in promoting primary, secondary, and tertiary prevention. Limited studies have explored this topic among patients with cancer in non-western, low-to-middle-income countries. A cross-sectional survey to compare Australian and Vietnamese... | 10.1177/1073274819863786 | 31,345,063 | D000367:Age Factors; D000368:Aged; D001315:Australia; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D005247:Feeding Behavior; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D010465:Perception; ... | Cancer control : journal of the Moffitt Cancer Center | 2,019 | |
Volume regulation of muscle cells in the carp Cyprinus carpio in response to hypernatremia. | BACKGROUND
Hypernatremia supports the movement of water from the intracellular to the intercellular space. This shift leads to cells shrinkage and disruption of intracellular processes, representing risk factors of morbidity and mortality in clinical circumstances. On the other hand, hypernatremia triggers protective m... | 10.4149/BLL_2019_008 | 30,685,993 | D000818:Animals; D002347:Carps; D006955:Hypernatremia; D008274:Magnesium; D018482:Muscle, Skeletal; D011188:Potassium; D012964:Sodium | Bratislavske lekarske listy | 2,019 | D012964:Sodium; D008274:Magnesium; D011188:Potassium |
Prevalence of rheumatic heart disease among school children in East Africa: a systematic review and meta-analysis. | INTRODUCTION
conducting researches and estimating the prevalence of rheumatic heart disease in school children is crucial to develop school-based strategies targeted to decrease the prevalence of this disease. Therefore, this systematic review and meta-analysis were aimed to estimate the overall prevalence of rheumatic... | 10.11604/pamj.2021.38.242.26058 | 34,104,290 | D000351:Africa, Eastern; D002648:Child; D006801:Humans; D007182:Income; D015995:Prevalence; D012214:Rheumatic Heart Disease; D012574:Schools | The Pan African medical journal | 2,021 | |
Shear stress activation of platelets with subsequent refractoriness. | Platelet rich plasma was prepared with soybean trypsin inhibitor (SBTI) as anticoagulant, to preserve normal Ca++-concentration, and subsequently tested in an aggregometer. Shear stress alone, induced by stirring, resulted in platelet aggregation and disaggregation. Such platelets showed only minor aggregational respon... | 10.1016/0049-3848(87)90254-4 | 3,563,976 | D000244:Adenosine Diphosphate; D001792:Blood Platelets; D002498:Centrifugation; D006801:Humans; D010974:Platelet Aggregation; D013314:Stress, Mechanical | Thrombosis research | 1,987 | D000244:Adenosine Diphosphate |
Taurine and ellagic acid: two differently-acting natural antioxidants. | Naturally occurring antimutagenic compounds are extensively analyzed for their capacity to protect cells from induced damage. We selected two agents, taurine and ellagic acid, treated in the literature as antioxidants, but whose activity is insufficiently known. This paper reports on the ability of these agents to act ... | 10.1002/em.2850260310 | 7,588,651 | D000818:Animals; D016587:Antimutagenic Agents; D000975:Antioxidants; D016466:CHO Cells; D002869:Chromosome Aberrations; D006224:Cricetinae; D004610:Ellagic Acid; D005434:Flow Cytometry; D006861:Hydrogen Peroxide; D016685:Mitomycin; D009152:Mutagenicity Tests; D009153:Mutagens; D012854:Sister Chromatid Exchange; D013654... | Environmental and molecular mutagenesis | 1,995 | D016587:Antimutagenic Agents; D000975:Antioxidants; D009153:Mutagens; D004610:Ellagic Acid; D013654:Taurine; D016685:Mitomycin; D006861:Hydrogen Peroxide |
Studies of coenzyme binding to rabbit muscle glyceraldehyde-3-phoshate dehydrogenase. | The binding of NAD+, NADH and adenosine diphosphoribose (Ado-PP-Rib) to a stable, highly active and nucleotide-free preparation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (D-glyceraldehyde-3-phosphate: NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12) has been studied. All three nucleotides quench the ... | 10.1016/0005-2744(75)90248-x | 167,830 | D000247:Adenosine Diphosphate Sugars; D000818:Animals; D001051:Apoenzymes; D001665:Binding Sites; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D007700:Kinetics; D009132:Muscles; D009243:NAD; D010084:Oxidation-Reduction; D011485:Protein Binding; D011817:Rabbits; D012266:Ribose; D013050:Spectrometry, Fluorescence; ... | Biochimica et biophysica acta | 1,975 | D000247:Adenosine Diphosphate Sugars; D001051:Apoenzymes; D009243:NAD; D012266:Ribose; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases |
Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway. | BACKGROUND
Previous preclinical and clinical studies have demonstrated that zoledronate might inhibit neointimal hyperplasia at least partly by inhibiting the proliferation, adhesion and migration of vascular smooth muscle cells (VSMCs). However, whether zoledronate influences fibroblasts' proliferation and activation,... | 10.2147/DDDT.S168897 | 30,271,117 | D000818:Animals; D002339:Carotid Arteries; D002453:Cell Cycle; D002465:Cell Movement; D049109:Cell Proliferation; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts; D051379:Mice; D041681:NIH 3T3 Cells; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D016212:Tra... | Drug design, development and therapy | 2,018 | D016212:Transforming Growth Factor beta; D000077211:Zoledronic Acid |
Ablative fractional laser therapy as treatment for Becker nevus: a randomized controlled pilot study. | BACKGROUND
Becker nevus (BN) is an uncommon pigment disorder characterized by hyperpigmentation and sometimes hypertrichosis. To date, no effective treatment has been available.
OBJECTIVES
We sought to assess efficacy and safety of ablative 10,600-nm fractional laser therapy (FLT) in the treatment of BN.
METHODS
El... | 10.1016/j.jaad.2010.07.049 | 21,641,077 | D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009506:Nevus; D010865:Pilot Projects; D011446:Prospective Studies; D016037:Single-Blind Method; D012878:Skin Neoplasms; D055815:Young Adult | Journal of the American Academy of Dermatology | 2,011 | |
Anomalous hybridization complementation effect on phonon transport in heterogeneous nanowire cross junction. | Controlling phonon transport via its wave nature in nanostructures can achieve unique properties for various applications. In this paper, thermal conductivity of heterogeneous nano cross junction (hetero-NCJ) is studied through molecular dynamics simulation. It is found that decreasing or increasing the atomic mass of ... | 10.1088/1361-648X/abfcff | 33,915,530 | Journal of physics. Condensed matter : an Institute of Physics journal | 2,021 | ||
An esophageal gastrointestinal stromal tumor in a patient with MEN1-related pancreatic gastrinoma: an unusual association and review of the literature. | Both multiple endocrine neoplasia type 1 (MEN1)-related gastrinomas and gastrointestinal stromal tumors (GISTs) are rare neoplasms, and their association has been rarely reported. We describe an unusual association between a GIST and a MEN1-related gastrinoma. A 44-year-old man had undergone surgical removal of a pancr... | 10.4103/0973-1482.136685 | 25,022,420 | D000328:Adult; D004938:Esophageal Neoplasms; D015408:Gastrinoma; D046152:Gastrointestinal Stromal Tumors; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1; D016609:Neoplasms, Second Primary; D010190:Pancreatic Neoplasms; D011518:Proto-Oncogene Proteins; D014463:Ultrason... | Journal of cancer research and therapeutics | 2,014 | C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins |
P-doped biochar regulates nZVI nanocracks formation for superefficient persulfate activation. | In this study, a novel P-doped biochar loaded with nano zero-valent iron (nZVI) composite (nZVI@P-BC), with abundant nanocracks from inside to outside in nZVI particles, was designed for ultra-efficient persulfate (PS) activation and gamma-hexachlorocyclohexane (γ-HCH) degradation. Results showed that P-doping treatmen... | 10.1016/j.jhazmat.2023.130999 | 36,848,845 | D007501:Iron; D001556:Hexachlorocyclohexane; D014874:Water Pollutants, Chemical; D002606:Charcoal | Journal of hazardous materials | 2,023 | D007501:Iron; C540010:biochar; D001556:Hexachlorocyclohexane; D014874:Water Pollutants, Chemical; D002606:Charcoal |
Explaining the variance in reading ability in terms of psychological processes: What have we learned? | After years of confusion, the literature on individual differences in reading ability is finally beginning to coalesce around a small set of general conclusions that are endorsed by the vast majority of researchers. The most fundamental is that word decoding ability accounts for a very large proportion of the variance ... | 10.1007/BF02659181 | 24,243,410 | Annals of dyslexia | 1,985 | ||
Somatic mutations of calreticulin in myeloproliferative neoplasms. | Recurrent somatic mutations in calreticulin (CALR) gene that encodes a molecular chaperone residing in the endoplasmic reticulum were identified in 2013 in a subset of patients with myeloproliferative neoplasms (MPNs). All of these mutations found in patients were either small insertion or deletion in a narrow region o... | 10.1007/s12185-017-2246-9 | 28,470,469 | D037282:Calreticulin; D005091:Exons; D016368:Frameshift Mutation; D019337:Hematologic Neoplasms; D006801:Humans; D009196:Myeloproliferative Disorders; D009363:Neoplasm Proteins; D000072417:Protein Domains | International journal of hematology | 2,017 | D037282:Calreticulin; D009363:Neoplasm Proteins |
First mtgenome sequences from three genera and phylogenetic relationships of the family Apidae based on mtgenome sequences (Hymenoptera: Apoidea). | In this study, we report the complete mitochondrial genomes (mtgenome) of Thyreus decorus, Ceratina okinawana and Amegilla calceifera, which are the first time of mtgenome report also for the genera Thyreus, Ceratina and Amegilla in the family Apidae. They contain 15,237, 15,207, and 17,728 bp, with AT content of 84.97... | 10.1080/23802359.2021.1903357 | 33,796,775 | Mitochondrial DNA. Part B, Resources | 2,021 | ||
Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior. | Integrins are cell-substrate adhesion molecules that provide the essential link between the actin cytoskeleton and the extracellular matrix during cell migration. We have analyzed alphaVbeta3-integrin dynamics in migrating cells using a green fluorescent protein-tagged beta3-integrin chain. At the cell front, adhesion ... | 10.1083/jcb.200107107 | 11,756,480 | D002478:Cells, Cultured; D005434:Flow Cytometry; D022001:Focal Adhesions; D006706:Homeostasis; D006801:Humans; D008856:Microscopy, Fluorescence; D018715:Microscopy, Video; D019030:Receptors, Vitronectin; D011993:Recombinant Fusion Proteins; D014162:Transfection | The Journal of cell biology | 2,001 | D019030:Receptors, Vitronectin; D011993:Recombinant Fusion Proteins |
Osteogenic differentiation from mouse adipose-derived stem cells and bone marrow stem cells. | Mesenchymal stem cells (MSCs) have been successfully cultured and proliferated in vitro and can differentiate into a variety of specific cell types, such as adipocytes or osteocytes, through chemical stimulation. One of the major applications of MSCs is in regenerative medicine research. MSCs can be collected from many... | 10.4103/cjp.cjp_64_21 | 35,229,749 | D000273:Adipose Tissue; D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002478:Cells, Cultured; D051379:Mice; D010012:Osteogenesis; D013234:Stem Cells | The Chinese journal of physiology | 2,022 | |
Prevention for oneself or others? Psychological and social factors that explain social distancing during the COVID-19 pandemic. | Identifying the underlying psychological and social factors of social distancing is crucial to foster preventive behavior during a pandemic effectively. We investigated the relative contribution of self-focused factors (fear of infection, fear of punishment) and other-focused factors (moral judgment, moral identity, em... | 10.1177/1359105320980793 | 33,302,730 | D000086382:COVID-19; D006801:Humans; D009014:Morals; D058873:Pandemics; D000085762:Physical Distancing; D000083663:Social Factors | Journal of health psychology | 2,022 | |
Terminal deoxynucleotidyl transferase-positive lymphoid cells in reactive lymph nodes from children with malignant tumors: incidence, distribution pattern, and immunophenotype in 26 patients. | The presence of terminal deoxynucleotidyl transferase (TdT)-positive lymphoid precursors in benign lymph nodes from children has been characterized insufficiently. By using single- and double-labeling immunohistochemical analysis, we examined the frequency, distribution, morphologic features, and immunophenotype of TdT... | 10.1309/L3UW-3AE7-L4LB-3QX3 | 12,162,686 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004253:DNA Nucleotidylexotransferase; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008198:Lymph Nodes; D008297:Male; D009369:Neoplasms; D012016:Reference Values | American journal of clinical pathology | 2,002 | D004253:DNA Nucleotidylexotransferase |
Primary testicular lymphoma. | Primary testicular lymphoma (PTL) is a rare disease accounting for 1% of non-Hodgkin's lymphoma. PTL occurs more frequently in older patients and is a potentially fatal disease. In the early stages (I and II), the treatment consists of orchidectomy followed by chemotherapy (CT) and prophylactic scrotal radiotherapy (RT... | 20,872,294 | D000368:Aged; D001932:Brain Neoplasms; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D006801:Humans; D015182:Lymphatic Irradiation; D008228:Lymphoma, Non-Hodgkin; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuv... | Swiss medical weekly | 2,010 | ||
Perinatal and pediatric nutrition. | Nutritional deficiencies develop rapidly in the very low birth weight infants because of a lack of third-trimester accumulation of fat, minerals, trace elements, and fat-soluble vitamins. Symptomatic zinc deficiency and hypernatremic dehydration may occur unexpectedly in the wholly breast-fed full-term or premature inf... | 8,319,426 | D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D006801:Humans; D007223:Infant; D007225:Infant Food; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D008895:Milk, Human; D008903:Minerals; D014131:Trace Elements; D014815:Vitamins | Clinics in laboratory medicine | 1,993 | D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D008903:Minerals; D014131:Trace Elements; D014815:Vitamins | |
[The regulatory functions of pro-inflammatory cytokines and acute-phase proteins]. | The paper provides a brief review of recent basic studies made by the Department of Immunology, Institute of Experimental Medicine, Saint Petersburg. They show that with a panel of macrophage-like cell lines of varying maturation (P388D, THP-1, U937, HL-60), the ability to produce TNF alpha spontaneously and to synthes... | 10,394,297 | D000209:Acute-Phase Proteins; D002460:Cell Line; D016207:Cytokines; D006801:Humans; D007111:Immunity, Cellular; D018836:Inflammation Mediators; D008264:Macrophages; D014409:Tumor Necrosis Factor-alpha | Vestnik Rossiiskoi akademii meditsinskikh nauk | 1,999 | D000209:Acute-Phase Proteins; D016207:Cytokines; D018836:Inflammation Mediators; D014409:Tumor Necrosis Factor-alpha | |
Interleukin-17 family and IL-17 receptors. | Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additio... | 10.1016/s1359-6101(03)00002-9 | 12,651,226 | D000595:Amino Acid Sequence; D001168:Arthritis; D002356:Cartilage; D002358:Cartilage, Articular; D004195:Disease Models, Animal; D020381:Interleukin-17; D008024:Ligands; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009369:Neoplasms; D010802:Phy... | Cytokine & growth factor reviews | 2,003 | D020381:Interleukin-17; D008024:Ligands; D018123:Receptors, Interleukin; D011994:Recombinant Proteins |
Tissue-specific expression of head-to-tail cyclized miniproteins in Violaceae and structure determination of the root cyclotide Viola hederacea root cyclotide1. | The plant cyclotides are a family of 28 to 37 amino acid miniproteins characterized by their head-to-tail cyclized peptide backbone and six absolutely conserved Cys residues arranged in a cystine knot motif: two disulfide bonds and the connecting backbone segments form a loop that is penetrated by the third disulfide b... | 10.1105/tpc.104.021790 | 15,295,104 | D000595:Amino Acid Sequence; D004220:Disulfides; D020869:Gene Expression Profiling; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic; D018517:Plant Roots; D011487:Protein Conformation; D016415:Sequence Alignment; D014018:Tissue Distribution; D032413:Viola; D029649:Violaceae | The Plant cell | 2,004 | D004220:Disulfides; D010456:Peptides, Cyclic |
A comparative study of extracellular enzymes from chromoblastomycosis agents reveals the potential association of phospholipase with the severity of the lesions. | Chromoblastomycosis is a chronic, progressive subcutaneous mycosis that is endemic in tropical and subtropical countries. Cladophialophora carrionii and Fonsecaea pedrosoi are prevalent etiological agents. The potential role of the proteolytic activity of extracellular enzymes in these fungi and its relationship with t... | 10.1016/j.micpath.2020.104367 | 32,649,963 | D000935:Antifungal Agents; D001203:Ascomycota; D002862:Chromoblastomycosis; D006801:Humans; D003904:Mitosporic Fungi; D010740:Phospholipases | Microbial pathogenesis | 2,020 | D000935:Antifungal Agents; D010740:Phospholipases |
[Inpatient preliminary examination. A model for the improvement of clinical psychotherapy]. | Hospitalization of patients for four days in order to carry out a psychodiagnostic examination is a model which, so far, has not been practised anywhere else in Germany. Experience in the Wittgenstein hospital during more than six years has shown that such a preliminary examination is able to achieve more than solving ... | 6,837,172 | D000328:Adult; D006801:Humans; D001523:Mental Disorders; D008875:Middle Aged; D010347:Patient Care Planning; D011567:Psychiatric Department, Hospital; D011575:Psychoanalytic Therapy; D011581:Psychological Tests; D012114:Residential Treatment | Zeitschrift fur Psychosomatische Medizin und Psychoanalyse | 1,983 | ||
Transcutaneous electrical nerve stimulation (TENS) of upper cervical nerve (C2) for the treatment of somatic tinnitus. | Somatic tinnitus has been defined as tinnitus temporally associated to a somatic disorder involving the head and neck. Several studies have demonstrated the interactions between the somatosensory and auditory system at the dorsal cochlear nucleus (DCN), inferior colliculus, and parietal association areas. The objective... | 10.1007/s00221-010-2304-5 | 20,505,927 | D000328:Adult; D000368:Aged; D001306:Auditory Pathways; D002572:Cervical Plexus; D017626:Cochlear Nucleus; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013003:Somatosensory Cortex; D014012:Tinnitus; D004561:Transcutaneous Electric Nerve Stimulation; D0168... | Experimental brain research | 2,010 | |
Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. | Poly(ADP-ribose) (PAR) is a post-translational modification of proteins and is synthesised by PAR polymerases (PARPs), which have long been associated with the coordination of the cellular response to DNA damage, amongst other processes. Binding of some PARPs such as PARP1 to broken DNA induces a substantial wave of PA... | 10.1007/s00412-013-0442-9 | 24,162,931 | D000818:Animals; D017209:Apoptosis; D002843:Chromatin; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases | Chromosoma | 2,014 | D002843:Chromatin; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases |
Purification and topographical location of tegumental alkaline phosphatase from adult Schistosoma mansoni. | Alkaline phosphatase, a marker for tegumental membranes of Schistosoma mansoni, was extracted using Triton X-100 from membranes purified by sucrose density gradient centrifugation. The enzyme activity was purified 6 800-fold over parasite homogenates and 118-fold over the tegumental membranes released when parasites we... | 10.1016/0166-6851(84)90125-7 | 6,527,695 | D000469:Alkaline Phosphatase; D000818:Animals; D002462:Cell Membrane; D006224:Cricetinae; D004591:Electrophoresis, Polyacrylamide Gel; D007422:Intestines; D007457:Iodine Radioisotopes; D008647:Mesocricetus; D008970:Molecular Weight; D012550:Schistosoma mansoni | Molecular and biochemical parasitology | 1,984 | D007457:Iodine Radioisotopes; D000469:Alkaline Phosphatase |
Total knee arthroplasty in the patient with Parkinson's disease. | We have reviewed nine patients with Parkinson's disease who had 12 primary total knee arthroplasties and one revision. Deformities were corrected by conventional techniques and semi-constrained resurfacing arthroplasties were used. Follow-up ranged from two to eight years (average 4.3 years). Nine of the 12 primary art... | 10.1302/0301-620X.71B1.2915005 | 2,915,005 | D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint; D007720:Knee Prosthesis; D008722:Methods; D008875:Middle Aged; D010003:Osteoarthritis; D010300:Parkinson Disease; D011183:Postoperative Complications; D011859:Radiography; D012189:Retrospective Studies | The Journal of bone and joint surgery. British volume | 1,989 | |
Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. | The potential of histidines to modulate the binding of agonists and antagonists to human platelet thromboxane A2 (TXA2) receptors was investigated. TXA2 receptors were purified from crude platelet membranes via affinity and wheat germ lectin chromatography. Radioligand binding studies were conducted using the TXA2, mim... | 10.1016/0006-2952(95)00015-r | 7,741,764 | D001792:Blood Platelets; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004047:Diethyl Pyrocarbonate; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019811:Hydroxylamine; D006898:Hydroxylamines; D011869:R... | Biochemical pharmacology | 1,995 | D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D006898:Hydroxylamines; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D044244:Receptors, Thromboxane A2, Prostaglandin H2; C061750:7-(3-(3-hydro... |
Horse antithymocyte globulin as salvage therapy after rabbit antithymocyte globulin for severe aplastic anemia. | The effectiveness of salvage therapy for aplastic anemia patients unresponsive to initial rabbit antithymocyte globulin (r-ATG) or cyclophosphamide is not known. We investigated the administration of standard horse ATG (h-ATG) plus cyclosporine (CsA) in patients who were refractory to initial r-ATG/CsA (n = 19) or cycl... | 10.1002/ajh.23669 | 24,415,649 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic; D000961:Antilymphocyte Serum; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D018592:Cross-Over Studies; D003520:Cyclophosphamide; D016572:Cyclosporine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016879... | American journal of hematology | 2,014 | D000961:Antilymphocyte Serum; D016572:Cyclosporine; D003520:Cyclophosphamide |
Caerulein in supramaximal doses fails to stimulate pancreatic growth, but it forces secretory granulopoiesis. | To determine how low or high dose of caerulein, a cholecystokinin analogue influence pancreatic growth, doses of caerulein were selected which were submaximal (1 microgram/kg i.p.) and supramaximal (10 micrograms/kg i.p.) for enzyme protein secretion. Rats were injected every 8 h for 7 days with saline, low, or high do... | 2,455,434 | D000681:Amylases; D000818:Animals; D002108:Ceruletide; D003594:Cytoplasmic Granules; D004247:DNA; D004305:Dose-Response Relationship, Drug; D004792:Enzyme Precursors; D008297:Male; D008854:Microscopy, Electron; D009929:Organ Size; D010179:Pancreas; D010189:Pancreatic Juice; D011506:Proteins; D051381:Rats; D011919:Rats,... | Acta physiologica Hungarica | 1,988 | D004792:Enzyme Precursors; D011506:Proteins; D002108:Ceruletide; D014362:Trypsinogen; D004247:DNA; D000681:Amylases; D014357:Trypsin | |
Tamoxifen-induced regression of breast cysts. | The use of Tamoxifen as treatment for breast cancer is well established and its use experimentally as prophylaxis is promising, but little has been written about mammographically detected changes in breast parenchyma as a result of Tamoxifen therapy. We report two cases of spontaneous regression of breast cysts after T... | 10.1016/s0899-7071(97)00076-4 | 9,543,585 | D000328:Adult; D018931:Antineoplastic Agents, Hormonal; D001943:Breast Neoplasms; D005260:Female; D005348:Fibrocystic Breast Disease; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D013629:Tamoxifen | Clinical imaging | 1,998 | D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen |
Free rectus abdominis musculocutaneous flap for head and neck reconstruction. | Surgery in the head and neck often results in large and complex tissue defects. The free rectus abdominis musculocutaneous flap has many advantages for reconstruction of these defects. A good volume of tissue can be harvested with a long and large-diameter vascular pedicle. A reliable blood supply enables thinning, sha... | 10.1055/s-2007-1006401 | 9,101,446 | D000009:Abdominal Muscles; D000368:Aged; D005260:Female; D006085:Graft Survival; D006257:Head; D006258:Head and Neck Neoplasms; D006801:Humans; D008297:Male; D008875:Middle Aged; D009333:Neck; D011183:Postoperative Complications; D013524:Surgical Flaps | Journal of reconstructive microsurgery | 1,997 | |
Estimating the Burden of Chagas Disease in the United States. | BACKGROUND
In recent years, there has been growing awareness of the significant burden of Chagas disease in the United States (US). However, epidemiological data on both prevalence and access to care for this disease are limited. The objective of this study is to provide an updated national estimate of Chagas disease p... | 10.1371/journal.pntd.0005033 | 27,820,837 | D000328:Adult; D001782:Blood Donors; D002140:California; D014355:Chagas Disease; D017281:Cost of Illness; D054242:Emigrants and Immigrants; D019353:Endemic Diseases; D005431:Florida; D006801:Humans; D015994:Incidence; D007843:Latin America; D008297:Male; D009518:New York; D015995:Prevalence; D013781:Texas; D014349:Tryp... | PLoS neglected tropical diseases | 2,016 | |
Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels. | Mice lacking ClC-3 chloride channels, encoded by the Clcn3 gene, undergo neurodegeneration of the hippocampal formation and retina [Neuron, 29 (2001) 185-196; Genes Cells, 7 (2002) 597-605]. We independently created a mouse lacking the Clcn3 gene which demonstrated similar central nervous system abnormalities, includin... | 10.1016/s0006-8993(02)03519-9 | 12,470,859 | D000818:Animals; D018118:Chloride Channels; D005260:Female; D005968:Glutamate Decarboxylase; D006624:Hippocampus; D007527:Isoenzymes; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009410:Nerve Degeneration; D019636:Neurodegenerative Diseases; D011963:Receptors, GABA-A; D012162:Retinal... | Brain research | 2,002 | D018118:Chloride Channels; C115376:ClC-3 channel; D007527:Isoenzymes; D011963:Receptors, GABA-A; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1 |
Prenatal diagnosis, natural history, postnatal treatment and outcome of 222 cases of spina bifida: experience of a tertiary center. | OBJECTIVES
To report on the prenatal ultrasonographic diagnosis of spina bifida (SB) and its natural history, treatment and long-term outcome in a large tertiary referral center.
METHODS
All cases of SB diagnosed between February 1980 and December 2015 in the Obstetric Prenatal Diagnosis Day Unit of the Obstetrics an... | 10.1002/uog.20136 | 30,288,814 | D002585:Cesarean Section; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011788:Quality of Life; D016135:Spinal Dysraphism; D016896:Treatment Outcome | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology | 2,019 | |
Response Dynamics in an Olivocerebellar Spiking Neural Network With Non-linear Neuron Properties. | Sensorimotor signals are integrated and processed by the cerebellar circuit to predict accurate control of actions. In order to investigate how single neuron dynamics and geometrical modular connectivity affect cerebellar processing, we have built an olivocerebellar Spiking Neural Network (SNN) based on a novel simplif... | 10.3389/fncom.2019.00068 | 31,632,258 | Frontiers in computational neuroscience | 2,019 | ||
Influence of carbohydrate-electrolyte drinks on marathon running performance. | The aim of this study was to compare the effects of drinking two carbohydrate (CHO) electrolyte solutions and water on marathon running performance. Seven endurance-trained runners completed three 42.2-km treadmill time-trials which were randomly assigned and 4 weeks apart. On each occasion the subjects ingested 3 ml.K... | 10.1007/BF00361543 | 7,768,238 | D000328:Adult; D000641:Ammonia; D001628:Beverages; D002241:Carbohydrates; D004326:Drinking; D004573:Electrolytes; D005230:Fatty Acids, Nonesterified; D005990:Glycerol; D006339:Heart Rate; D006728:Hormones; D006801:Humans; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D010101:Oxygen Consumption; D010807:Physical ... | European journal of applied physiology and occupational physiology | 1,995 | D002241:Carbohydrates; D004573:Electrolytes; D005230:Fatty Acids, Nonesterified; D006728:Hormones; D007773:Lactates; D019344:Lactic Acid; D000641:Ammonia; D005990:Glycerol |
Effect of pertussis toxin injected into the ventral tegmental area on amphetamine-induced Fos protein in the nucleus accumbens. | Amphetamine produces an enhanced locomotor stimulatory response in animals injected with pertussis toxin into the ventral tegmental area. This response is dependent on the activation of D1 receptors in the nucleus accumbens. The immediate early gene, c-Fos, has been used as a cellular marker for increases in dopamine n... | 10.1016/s0361-9230(97)00030-0 | 9,241,447 | D000661:Amphetamine; D000818:Animals; D007150:Immunohistochemistry; D008297:Male; D009714:Nucleus Accumbens; D037342:Pertussis Toxin; D016760:Proto-Oncogene Proteins c-fos; D051381:Rats; D017207:Rats, Sprague-Dawley; D013681:Tegmentum Mesencephali; D010566:Virulence Factors, Bordetella | Brain research bulletin | 1,997 | D016760:Proto-Oncogene Proteins c-fos; D010566:Virulence Factors, Bordetella; D000661:Amphetamine; D037342:Pertussis Toxin |
[Fever with a rash caused by chronic meningococcemia]. | BACKGROUND
Fever with a rash is a common clinical presentation, which can be caused by various medical conditions.
CASE DESCRIPTION
A 14-year old boy presented at the outpatient clinic with a two-week history of fever, myalgia and purpuric skin lesions. Blood cultures showed an infection with Neisseria meningitidis. ... | 25,850,448 | D000293:Adolescent; D000900:Anti-Bacterial Agents; D016470:Bacteremia; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005076:Exanthema; D005334:Fever; D006801:Humans; D008297:Male; D008589:Meningococcal Infections; D009345:Neisseria meningitidis | Nederlands tijdschrift voor geneeskunde | 2,015 | D000900:Anti-Bacterial Agents | |
Hospitalized Patients With and Without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis. | BACKGROUND
Despite being in clinical use for about 6 decades, vancomycin dosing remains perplexing and complex.
METHODS
A population pharmacokinetic modeling and simulation approach was used to evaluate the efficiency of the current nomogram-based dosing of vancomycin. Serum vancomycin concentrations were obtained as... | 10.1097/FTD.0000000000000490 | 29,470,227 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016903:Drug Monitoring; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D006435:Renal Dialysis; D012189:Retrospective Studies; D014640:Vancomycin; D055815:Young Adult | Therapeutic drug monitoring | 2,018 | D014640:Vancomycin |
Orthokeratology: clinical utility and patient perspectives. | Orthokeratology (ortho-k) is a special rigid contact lens worn at night to achieve myopic reduction and control. This review provides an overview on prescribing ortho-k, including clinical consideration on patient aspect and lens design; its clinical outcomes; and clinical efficacy and safety. Patient satisfaction was ... | 10.2147/OPTO.S104507 | 30,214,358 | Clinical optometry | 2,017 |
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