drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01100 | DB01409 | 1,568 | 1,415 | [
"DDInter1470",
"DDInter1815"
] | Pimozide | Tiotropium | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1568,
24,
1415
]
],
[
[
1568,
6,
4304
],
[
4304,
45,
1415
]
],
[
[
1568,
21,
28996
],
[
28996,
60,
1415
]
],
[
[
1568,
64,
752
],
[
75... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Pimozide",
"{u} (Compound) binds {v} (Gene)",
"CHRM2"
],
[
"CHRM2",
"{u} (Gene) is bound by {v} (Compound)",
... | Pimozide (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Tiotropium (Compound)
Pimozide (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Tiotropium (Compound)
Pimozide may lead to a major life threatening interaction when taken with Cimetidi... |
DB00365 | DB05239 | 839 | 866 | [
"DDInter842",
"DDInter425"
] | Grepafloxacin | Cobimetinib | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
839,
24,
866
]
],
[
[
839,
25,
888
],
[
888,
24,
866
]
],
[
[
839,
24,
1478
],
[
1478,
63,
866
]
],
[
[
839,
62,
482
],
[
482,
2... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
],
[
"Tamo... | Grepafloxacin may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cau... |
DB01142 | DB06767 | 1,264 | 732 | [
"DDInter593",
"DDInter80"
] | Doxepin | Ammonium chloride | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Ammonium chloride is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions. | Minor | 0 | [
[
[
1264,
23,
732
]
],
[
[
1264,
64,
576
],
[
576,
23,
732
]
],
[
[
1264,
74,
1164
],
[
1164,
23,
732
]
],
[
[
1264,
25,
22
],
[
22,
... | [
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ammonium chloride"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methadone"
],
[
"Methadone",
... | Doxepin may lead to a major life threatening interaction when taken with Methadone and Methadone may cause a minor interaction that can limit clinical effects when taken with Ammonium chloride
Doxepin (Compound) resembles Trimipramine (Compound) and Doxepin may cause a moderate interaction that could exacerbate disease... |
DB00593 | DB04837 | 1,464 | 649 | [
"DDInter695",
"DDInter407"
] | Ethosuximide | Clofedanol | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1464,
24,
649
]
],
[
[
1464,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1464,
24,
832
],
[
832,
40,
649
]
],
[
[
1464,
63,
701
],
[
701,
... | [
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],... | Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Tripele... |
DB00342 | DB11986 | 1,181 | 484 | [
"DDInter1770",
"DDInter648"
] | Terfenadine | Entrectinib | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1181,
24,
484
]
],
[
[
1181,
23,
1247
],
[
1247,
23,
484
]
],
[
[
1181,
24,
1539
],
[
1539,
24,
484
]
],
[
[
1181,
25,
1662
],
[
1662,... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin ... |
DB00357 | DB09073 | 1,051 | 951 | [
"DDInter71",
"DDInter1379"
] | Aminoglutethimide | Palbociclib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1051,
24,
951
]
],
[
[
1051,
24,
907
],
[
907,
62,
951
]
],
[
[
1051,
23,
271
],
[
271,
23,
951
]
],
[
[
1051,
24,
479
],
[
479,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doravirine"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Mirabegron... |
DB15091 | DB15982 | 676 | 1,339 | [
"DDInter1901",
"DDInter193"
] | Upadacitinib | Berotralstat | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
676,
24,
1339
]
],
[
[
676,
64,
1101
],
[
1101,
23,
1339
]
],
[
[
676,
63,
283
],
[
283,
23,
1339
]
],
[
[
676,
64,
1213
],
[
1213,
... | [
[
[
"Upadacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Upadacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexa... | Upadacitinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may ca... |
DB06168 | DB06176 | 1,531 | 1,342 | [
"DDInter281",
"DDInter1616"
] | Canakinumab | Romidepsin | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1531,
24,
1342
]
],
[
[
1531,
63,
336
],
[
336,
24,
1342
]
],
[
[
1531,
24,
1491
],
[
1491,
63,
1342
]
],
[
[
1531,
62,
1461
],
[
1461... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
[
... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Mid... |
DB00682 | DB01220 | 126 | 1,088 | [
"DDInter1951",
"DDInter1593"
] | Warfarin | Rifaximin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Moderate | 1 | [
[
[
126,
24,
1088
]
],
[
[
126,
25,
463
],
[
463,
1,
1088
]
],
[
[
126,
64,
690
],
[
690,
1,
1088
]
],
[
[
126,
6,
8374
],
[
8374,
4... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifaximin"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rifampicin"
],
[
"Rifampicin",
... | Warfarin may lead to a major life threatening interaction when taken with Rifampicin and Rifampicin (Compound) resembles Rifaximin (Compound)
Warfarin may lead to a major life threatening interaction when taken with Rifabutin and Rifabutin (Compound) resembles Rifaximin (Compound)
Warfarin (Compound) binds CYP3A4 (Gene... |
DB09065 | DB15233 | 760 | 1,650 | [
"DDInter424",
"DDInter142"
] | Cobicistat | Avapritinib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
760,
25,
1650
]
],
[
[
760,
64,
1478
],
[
1478,
24,
1650
]
],
[
[
760,
62,
1374
],
[
1374,
24,
1650
]
],
[
[
760,
25,
159
],
[
159,
... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",
"{u} ma... | Cobicistat may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Cobicistat may cause a minor interaction that can limit clinical effects when taken with Abiraterone and Abiraterone may cause a... |
DB00258 | DB01396 | 666 | 1,482 | [
"DDInter270",
"DDInter553"
] | Calcium acetate | Digitoxin | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
666,
24,
1482
]
],
[
[
666,
24,
1252
],
[
1252,
1,
1482
]
],
[
[
666,
24,
542
],
[
542,
24,
1482
]
],
[
[
666,
63,
964
],
[
964,
... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine may cause a moderate interaction t... |
DB00777 | DB01041 | 146 | 770 | [
"DDInter1537",
"DDInter1789"
] | Propiomazine | Thalidomide | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
146,
24,
770
]
],
[
[
146,
24,
849
],
[
849,
63,
770
]
],
[
[
146,
40,
684
],
[
684,
24,
770
]
],
[
[
146,
63,
1614
],
[
1614,
2... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Propiomazine (Compound) resembles Thioridazine (Compound) and Thioridazine may cause a moderate interaction t... |
DB00758 | DB01006 | 1,347 | 300 | [
"DDInter413",
"DDInter1040"
] | Clopidogrel | Letrozole | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Moderate | 1 | [
[
[
1347,
24,
300
]
],
[
[
1347,
6,
8374
],
[
8374,
45,
300
]
],
[
[
1347,
21,
28646
],
[
28646,
60,
300
]
],
[
[
1347,
63,
307
],
[
307,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Letrozole"
]
],
[
[
"Clopidogrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Clopidogrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Letrozole (Compound)
Clopidogrel (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Letrozole (Compound)
Clopidogrel may cause a ... |
DB00747 | DB00831 | 1,442 | 1,178 | [
"DDInter1647",
"DDInter1866"
] | Scopolamine | Trifluoperazine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1442,
24,
1178
]
],
[
[
1442,
63,
695
],
[
695,
40,
1178
]
],
[
[
1442,
24,
146
],
[
146,
40,
1178
]
],
[
[
1442,
24,
9
],
[
9,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine (Compound) resembles Trifluoperazi... |
DB00816 | DB01037 | 1,674 | 1,161 | [
"DDInter1346",
"DDInter1653"
] | Orciprenaline | Selegiline | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Moderate | 1 | [
[
[
1674,
24,
1161
]
],
[
[
1674,
63,
551
],
[
551,
1,
1161
]
],
[
[
1674,
24,
1529
],
[
1529,
1,
1161
]
],
[
[
1674,
24,
280
],
[
280,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Selegiline (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Selegiline... |
DB00675 | DB12010 | 888 | 214 | [
"DDInter1744",
"DDInter785"
] | Tamoxifen | Fostamatinib | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
888,
24,
214
]
],
[
[
888,
63,
723
],
[
723,
24,
214
]
],
[
[
888,
24,
861
],
[
861,
63,
214
]
],
[
[
888,
24,
866
],
[
866,
24,... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib and Ripret... |
DB00258 | DB01044 | 666 | 246 | [
"DDInter270",
"DDInter809"
] | Calcium acetate | Gatifloxacin | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Moderate | 1 | [
[
[
666,
24,
246
]
],
[
[
666,
24,
739
],
[
739,
1,
246
]
],
[
[
666,
63,
1176
],
[
1176,
1,
246
]
],
[
[
666,
24,
945
],
[
945,
40,... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ga... |
DB00405 | DB00801 | 128 | 1,563 | [
"DDInter517",
"DDInter850"
] | Dexbrompheniramine | Halazepam | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Moderate | 1 | [
[
[
128,
24,
1563
]
],
[
[
128,
24,
686
],
[
686,
1,
1563
]
],
[
[
128,
63,
902
],
[
902,
40,
1563
]
],
[
[
128,
63,
523
],
[
523,
1... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halazepam"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Oxazepam and Oxazepam (Compound) resembles Halazepam (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Halazepam (Comp... |
DB01105 | DB06077 | 222 | 879 | [
"DDInter1665",
"DDInter1102"
] | Sibutramine | Lumateperone | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
222,
24,
879
]
],
[
[
222,
24,
214
],
[
214,
63,
879
]
],
[
[
222,
63,
1645
],
[
1645,
24,
879
]
],
[
[
222,
24,
392
],
[
392,
2... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and... |
DB00284 | DB01267 | 1,647 | 519 | [
"DDInter11",
"DDInter1381"
] | Acarbose | Paliperidone | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1647,
24,
519
]
],
[
[
1647,
24,
1664
],
[
1664,
1,
519
]
],
[
[
1647,
21,
28898
],
[
28898,
60,
519
]
],
[
[
1647,
23,
135
],
[
135,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Acarbose (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Paliperidone (Compound)
Acarbose may cause a minor interacti... |
DB00039 | DB00444 | 1,253 | 63 | [
"DDInter1380",
"DDInter1765"
] | Palifermin | Teniposide | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Moderate | 1 | [
[
[
1253,
24,
63
]
],
[
[
1253,
24,
147
],
[
147,
62,
63
]
],
[
[
1253,
24,
738
],
[
738,
63,
63
]
],
[
[
1253,
24,
599
],
[
599,
24... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teniposide"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Teniposide
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Nirapar... |
DB00023 | DB06718 | 305 | 1,687 | [
"DDInter127",
"DDInter1709"
] | Asparaginase Escherichia coli | Stanozolol | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
305,
24,
1687
]
],
[
[
305,
24,
1197
],
[
1197,
1,
1687
]
],
[
[
305,
24,
1561
],
[
1561,
40,
1687
]
],
[
[
305,
24,
1573
],
[
1573,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) resembles Stanozolol (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testos... |
DB00377 | DB00844 | 1,494 | 314 | [
"DDInter1382",
"DDInter1257"
] | Palonosetron | Nalbuphine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Moderate | 1 | [
[
[
1494,
24,
314
]
],
[
[
1494,
24,
828
],
[
828,
40,
314
]
],
[
[
1494,
63,
421
],
[
421,
1,
314
]
],
[
[
1494,
63,
475
],
[
475,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Nalbuphine (Co... |
DB00277 | DB01199 | 1,031 | 1,217 | [
"DDInter1791",
"DDInter1890"
] | Theophylline | Tubocurarine | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera _Chondrodend... | Moderate | 1 | [
[
[
1031,
24,
1217
]
],
[
[
1031,
24,
545
],
[
545,
1,
1217
]
],
[
[
1031,
24,
1194
],
[
1194,
23,
1217
]
],
[
[
1031,
24,
1573
],
[
1573,... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubocurarine"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metocurine"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Metocurine and Metocurine (Compound) resembles Tubocurarine (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine may cause a minor interaction that ca... |
DB00208 | DB00278 | 1,018 | 291 | [
"DDInter1804",
"DDInter117"
] | Ticlopidine | Argatroban | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Major | 2 | [
[
[
1018,
25,
291
]
],
[
[
1018,
6,
8374
],
[
8374,
45,
291
]
],
[
[
1018,
21,
28931
],
[
28931,
60,
291
]
],
[
[
1018,
23,
297
],
[
297,
... | [
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Argatroban"
]
],
[
[
"Ticlopidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Argat... | Ticlopidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Argatroban (Compound)
Ticlopidine (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Argatroban (Compound)
Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Clove and Clov... |
DB00477 | DB01075 | 216 | 1,376 | [
"DDInter363",
"DDInter569"
] | Chlorpromazine | Diphenhydramine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
216,
24,
1376
]
],
[
[
216,
24,
649
],
[
649,
63,
1376
]
],
[
[
216,
25,
11
],
[
11,
1,
1376
]
],
[
[
216,
63,
128
],
[
128,
24,... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Chlorpromazine may lead to a major life threatening interaction when taken with Toremifene and Toremife... |
DB00387 | DB01278 | 1,386 | 1,021 | [
"DDInter1528",
"DDInter1506"
] | Procyclidine | Pramlintide | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1386,
24,
1021
]
],
[
[
1386,
24,
1507
],
[
1507,
24,
1021
]
],
[
[
1386,
40,
1105
],
[
1105,
24,
1021
]
],
[
[
1386,
35,
1192
],
[
11... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Procyclidine (Compound) resembles Trihexyphenidyl (Compound) and Trihexyphenidyl may cause a moderate inter... |
DB01181 | DB14443 | 1,532 | 987 | [
"DDInter906",
"DDInter1931"
] | Ifosfamide | Vibrio cholerae CVD 103-HgR strain live antigen | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1532,
24,
987
]
],
[
[
1532,
63,
141
],
[
141,
24,
987
]
],
[
[
1532,
24,
351
],
[
351,
24,
987
]
],
[
[
1532,
64,
581
],
[
581,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Ifosfamide may cause a moderate interaction that could exacerbate disease... |
DB00497 | DB00836 | 828 | 543 | [
"DDInter1366",
"DDInter1088"
] | Oxycodone | Loperamide | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
828,
24,
543
]
],
[
[
828,
24,
649
],
[
649,
1,
543
]
],
[
[
828,
24,
262
],
[
262,
24,
543
]
],
[
[
828,
63,
1242
],
[
1242,
24... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Loperamide (Compound)
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that could exa... |
DB01224 | DB06292 | 623 | 549 | [
"DDInter1553",
"DDInter474"
] | Quetiapine | Dapagliflozin | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
623,
24,
549
]
],
[
[
623,
24,
1344
],
[
1344,
40,
549
]
],
[
[
623,
6,
8374
],
[
8374,
45,
549
]
],
[
[
623,
21,
29222
],
[
29222,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Quetiapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Quetiapine (Compound) causes Hypoglycaemia (Side Effec... |
DB09330 | DB11793 | 985 | 738 | [
"DDInter1352",
"DDInter1297"
] | Osimertinib | Niraparib | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
985,
24,
738
]
],
[
[
985,
24,
466
],
[
466,
63,
738
]
],
[
[
985,
64,
1213
],
[
1213,
24,
738
]
],
[
[
985,
63,
663
],
[
663,
2... | [
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Osimertinib may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cau... |
DB01255 | DB11718 | 633 | 927 | [
"DDInter1078",
"DDInter640"
] | Lisdexamfetamine | Encorafenib | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
633,
24,
927
]
],
[
[
633,
62,
112
],
[
112,
23,
927
]
],
[
[
633,
24,
720
],
[
720,
24,
927
]
],
[
[
633,
63,
1520
],
[
1520,
2... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Minera... |
DB00472 | DB06282 | 758 | 516 | [
"DDInter758",
"DDInter1053"
] | Fluoxetine | Levocetirizine | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
758,
24,
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]
],
[
[
758,
63,
701
],
[
701,
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516
]
],
[
[
758,
24,
1614
],
[
1614,
24,
516
]
],
[
[
758,
40,
358
],
[
358,
2... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabi... |
DB01232 | DB11581 | 1,327 | 1,456 | [
"DDInter1640",
"DDInter1926"
] | Saquinavir | Venetoclax | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
1327,
25,
1456
]
],
[
[
1327,
25,
1135
],
[
1135,
23,
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]
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[
[
1327,
25,
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],
[
1476,
63,
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]
],
[
[
1327,
63,
86
],
[
86,
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Saquinavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Saquinavir may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interact... |
DB00624 | DB01254 | 1,561 | 1,213 | [
"DDInter1775",
"DDInter484"
] | Testosterone | Dasatinib | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1561,
24,
1213
]
],
[
[
1561,
6,
17404
],
[
17404,
45,
1213
]
],
[
[
1561,
7,
19092
],
[
19092,
46,
1213
]
],
[
[
1561,
18,
7335
],
[
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Testosterone",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)"... | Testosterone (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Testosterone (Compound) upregulates SPDEF (Gene) and SPDEF (Gene) is upregulated by Dasatinib (Compound)
Testosterone (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is downregulated by Dasatinib (Compound)
Testosterone (C... |
DB00622 | DB11093 | 1,081 | 636 | [
"DDInter1287",
"DDInter273"
] | Nicardipine | Calcium citrate | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1081,
24,
636
]
],
[
[
1081,
40,
409
],
[
409,
24,
636
]
],
[
[
1081,
40,
409
],
[
409,
1,
376
],
[
376,
24,
636
]
],
[
[
1081,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Nicardipine",
"{u} (Compound) resembles {v} (Compound)",
"Felodipine"
],
[
"Felodipine",
"{u} may cause a ... | Nicardipine (Compound) resembles Felodipine (Compound) and Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Nicardipine (Compound) resembles Felodipine (Compound) and Felodipine (Compound) resembles Amlodipine (Compound) and Amlodipine may cause a moderate inter... |
DB00220 | DB04845 | 798 | 309 | [
"DDInter1276",
"DDInter1001"
] | Nelfinavir | Ixabepilone | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
798,
24,
309
]
],
[
[
798,
6,
8374
],
[
8374,
45,
309
]
],
[
[
798,
21,
28736
],
[
28736,
60,
309
]
],
[
[
798,
24,
1419
],
[
1419,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Nelfinavir (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone (Compound)
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and ... |
DB00619 | DB00734 | 1,419 | 1,664 | [
"DDInter909",
"DDInter1605"
] | Imatinib | Risperidone | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
1419,
24,
1664
]
],
[
[
1419,
6,
4973
],
[
4973,
45,
1664
]
],
[
[
1419,
21,
28787
],
[
28787,
60,
1664
]
],
[
[
1419,
63,
752
],
[
75... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Risperidone (Compound)
Imatinib (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Risperidone (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidi... |
DB00773 | DB00978 | 896 | 739 | [
"DDInter702",
"DDInter1084"
] | Etoposide | Lomefloxacin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Minor | 0 | [
[
[
896,
23,
739
]
],
[
[
896,
23,
945
],
[
945,
40,
739
]
],
[
[
896,
62,
1176
],
[
1176,
1,
739
]
],
[
[
896,
62,
1467
],
[
1467,
... | [
[
[
"Etoposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Etoposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
],
[
... | Etoposide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Etoposide may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Lomefloxacin (Comp... |
DB00297 | DB00907 | 606 | 290 | [
"DDInter250",
"DDInter427"
] | Bupivacaine (liposome) | Cocaine (topical) | 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide is a piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline. It is a piperidinecarboxamide, an aromatic amide and a tertiary amino compound. It is a conjugate base of a 1-butyl... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
606,
24,
290
]
],
[
[
606,
6,
12523
],
[
12523,
45,
290
]
],
[
[
606,
21,
28741
],
[
28741,
60,
290
]
],
[
[
606,
40,
815
],
[
815,
... | [
[
[
"Bupivacaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Bupivacaine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Bupivacaine may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Bupivacaine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cocaine (Compound)
Bupivacaine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Cocaine (Compound)
Bupivacaine (C... |
DB00564 | DB01259 | 1,236 | 392 | [
"DDInter293",
"DDInter1024"
] | Carbamazepine | Lapatinib | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1236,
24,
392
]
],
[
[
1236,
6,
4973
],
[
4973,
45,
392
]
],
[
[
1236,
18,
10375
],
[
10375,
57,
392
]
],
[
[
1236,
21,
29429
],
[
294... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound... | Carbamazepine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Carbamazepine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Lapatinib (Compound)
Carbamazepine (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapat... |
DB01041 | DB09473 | 770 | 884 | [
"DDInter1789",
"DDInter918"
] | Thalidomide | Indium In-111 oxyquinoline | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
770,
24,
884
]
],
[
[
770,
64,
891
],
[
891,
24,
884
]
],
[
[
770,
63,
597
],
[
597,
24,
884
]
],
[
[
770,
24,
148
],
[
148,
63,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisolone"
],
... | Thalidomide may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenico... |
DB00015 | DB06081 | 582 | 1,046 | [
"DDInter1585",
"DDInter286"
] | Reteplase | Caplacizumab | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Major | 2 | [
[
[
582,
25,
1046
]
],
[
[
582,
23,
1631
],
[
1631,
62,
1046
]
],
[
[
582,
24,
1039
],
[
1039,
24,
1046
]
],
[
[
582,
24,
1427
],
[
1427,
... | [
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric",
... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Caplacizumab
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenflu... |
DB00197 | DB00349 | 1,324 | 902 | [
"DDInter1881",
"DDInter401"
] | Troglitazone | Clobazam | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Moderate | 1 | [
[
[
1324,
24,
902
]
],
[
[
1324,
24,
1382
],
[
1382,
1,
902
]
],
[
[
1324,
63,
168
],
[
168,
23,
902
]
],
[
[
1324,
24,
723
],
[
723,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clobazam"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midazolam"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Clobazam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limi... |
DB09330 | DB11057 | 985 | 720 | [
"DDInter1352",
"DDInter1223"
] | Osimertinib | Mineral oil | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
985,
24,
720
]
],
[
[
985,
25,
927
],
[
927,
63,
720
]
],
[
[
985,
64,
1151
],
[
1151,
24,
720
]
],
[
[
985,
63,
898
],
[
898,
2... | [
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Osimertinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encora... | Osimertinib may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Osimertinib may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a moderate i... |
DB00434 | DB09076 | 13 | 1,116 | [
"DDInter459",
"DDInter1899"
] | Cyproheptadine | Umeclidinium | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
13,
24,
1116
]
],
[
[
13,
24,
849
],
[
849,
24,
1116
]
],
[
[
13,
74,
695
],
[
695,
24,
1116
]
],
[
[
13,
63,
128
],
[
128,
24,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Cyproheptadine (Compound) resembles Clozapine (Compound) and Cyproheptadine may cause a moderate interacti... |
DB12141 | DB12457 | 971 | 1,180 | [
"DDInter817",
"DDInter1598"
] | Gilteritinib | Rimegepant | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Moderate | 1 | [
[
[
971,
24,
1180
]
],
[
[
971,
63,
741
],
[
741,
24,
1180
]
],
[
[
971,
24,
1619
],
[
1619,
24,
1180
]
],
[
[
971,
64,
351
],
[
351,
... | [
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimegepant"
]
],
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
... | Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruc... |
DB00848 | DB14711 | 281 | 779 | [
"DDInter1044",
"DDInter1680"
] | Levamisole | Smallpox (Vaccinia) Vaccine, Live | Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this,... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
281,
25,
779
]
],
[
[
281,
64,
1064
],
[
1064,
25,
779
]
],
[
[
281,
25,
1377
],
[
1377,
25,
779
]
],
[
[
281,
24,
270
],
[
270,
... | [
[
[
"Levamisole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Levamisole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cl... | Levamisole may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Levamisole may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may lead to a m... |
DB01215 | DB01246 | 1,418 | 820 | [
"DDInter677",
"DDInter45"
] | Estazolam | Alimemazine | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1418,
24,
820
]
],
[
[
1418,
63,
401
],
[
401,
24,
820
]
],
[
[
1418,
24,
649
],
[
649,
1,
820
]
],
[
[
1418,
6,
8374
],
[
8374,
... | [
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clo... |
DB00475 | DB09420 | 1,119 | 1,074 | [
"DDInter355",
"DDInter953"
] | Chlordiazepoxide | Iodide I-123 | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1119,
24,
1074
]
],
[
[
1119,
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],
[
516,
24,
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[
[
1119,
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],
[
902,
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]
],
[
[
1119,
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126
],
[
126,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizin... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Chlordiazepoxide (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate inte... |
DB00531 | DB01042 | 450 | 1,307 | [
"DDInter456",
"DDInter1144"
] | Cyclophosphamide | Melphalan | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Moderate | 1 | [
[
[
450,
24,
1307
]
],
[
[
450,
21,
28766
],
[
28766,
60,
1307
]
],
[
[
450,
23,
956
],
[
956,
62,
1307
]
],
[
[
450,
23,
739
],
[
739,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) causes {v} (Side Effect)",
"Hypotension"
],
[
"Hypotension",
"{u} (Side ... | Cyclophosphamide (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Melphalan (Compound)
Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin may cause a minor interaction that can limit clinical effects when taken... |
DB00903 | DB08907 | 1,680 | 1,344 | [
"DDInter686",
"DDInter280"
] | Etacrynic acid | Canagliflozin | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1680,
24,
1344
]
],
[
[
1680,
24,
549
],
[
549,
1,
1344
]
],
[
[
1680,
6,
1829
],
[
1829,
45,
1344
]
],
[
[
1680,
21,
28680
],
[
28680... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Etacrynic acid (Compound) binds ALB (Gene) and ALB (Gene) is bound by Canagliflozin (Compound)
Etacrynic acid (Compound) causes Rash (Side Effect) ... |
DB00283 | DB00734 | 701 | 1,664 | [
"DDInter395",
"DDInter1605"
] | Clemastine | Risperidone | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
701,
24,
1664
]
],
[
[
701,
24,
924
],
[
924,
40,
1664
]
],
[
[
701,
6,
12523
],
[
12523,
45,
1664
]
],
[
[
701,
21,
28956
],
[
28956,... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Clemastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Risperidone (Compound)
Clemastine (Compound) causes Palpitations (Side Effect) and Pa... |
DB00398 | DB08826 | 79 | 1,292 | [
"DDInter1702",
"DDInter489"
] | Sorafenib | Deferiprone | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
79,
25,
1292
]
],
[
[
79,
18,
2215
],
[
2215,
57,
1292
]
],
[
[
79,
21,
28759
],
[
28759,
60,
1292
]
],
[
[
79,
24,
1017
],
[
1017,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Sorafenib",
"{u} (Compound) downregulates {v} (Gene)",
"HSPA8"
],
[
"HSPA8",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Sorafenib (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Sorafenib (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Deferiprone (Compound)
Sorafenib may cause a moderate interaction that could exacerba... |
DB00563 | DB04865 | 663 | 4 | [
"DDInter1174",
"DDInter1335"
] | Methotrexate | Omacetaxine mepesuccinate | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
663,
24,
4
]
],
[
[
663,
18,
13042
],
[
13042,
46,
4
]
],
[
[
663,
7,
1720
],
[
1720,
46,
4
]
],
[
[
663,
7,
2389
],
[
2389,
57,... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Methotrexate",
"{u} (Compound) downregulates {v} (Gene)",
"HIST1H2BK"
],
[
"HIST1H2BK",
"{u} (G... | Methotrexate (Compound) downregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Methotrexate (Compound) upregulates RELB (Gene) and RELB (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Methotrexate (Compound) upregulates CCDC85B (Gene) and CCDC85B (Gene) ... |
DB00501 | DB04575 | 752 | 35 | [
"DDInter380",
"DDInter1555"
] | Cimetidine | Quinestrol | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | The 3-cyclopentyl ether of ethinyl estradiol. | Minor | 0 | [
[
[
752,
23,
35
]
],
[
[
752,
23,
890
],
[
890,
1,
35
]
],
[
[
752,
62,
380
],
[
380,
1,
35
]
],
[
[
752,
24,
1264
],
[
1264,
23,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Quinestrol"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mestranol"
],
[
"... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles Quinestr... |
DB00289 | DB01001 | 847 | 688 | [
"DDInter132",
"DDInter1632"
] | Atomoxetine | Salbutamol | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
847,
24,
688
]
],
[
[
847,
24,
874
],
[
874,
24,
688
]
],
[
[
847,
24,
1148
],
[
1148,
63,
688
]
],
[
[
847,
6,
8374
],
[
8374,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[... | Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and ... |
DB04574 | DB12332 | 177 | 1,619 | [
"DDInter684",
"DDInter1626"
] | Estrone sulfate (topical) | Rucaparib | Estrone 3-sulfate is a steroid sulfate that is the 3-sulfate of estrone. It has a role as a human metabolite and a mouse metabolite. It is a 17-oxo steroid and a steroid sulfate. It is functionally related to an estrone. It is a conjugate acid of an estrone 3-sulfate(1-). It derives from a hydride of an estrane. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
177,
24,
1619
]
],
[
[
177,
63,
1419
],
[
1419,
24,
1619
]
],
[
[
177,
24,
1019
],
[
1019,
24,
1619
]
],
[
[
177,
40,
1438
],
[
1438,
... | [
[
[
"Estrone sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Estrone sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
... | Estrone sulfate may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Estrone sulfate may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Estron... |
DB00500 | DB00731 | 24 | 1,144 | [
"DDInter1831",
"DDInter1269"
] | Tolmetin | Nateglinide | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
24,
24,
1144
]
],
[
[
24,
6,
10522
],
[
10522,
45,
1144
]
],
[
[
24,
21,
28722
],
[
28722,
60,
1144
]
],
[
[
24,
24,
121
],
[
121,
... | [
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Tolmetin",
"{u} (Compound) binds {v} (Gene)",
"PTGS1"
],
[
"PTGS1",
"{u} (Gene) is bound by {v} (Compound)",
... | Tolmetin (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Nateglinide (Compound)
Tolmetin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Nateglinide (Compound)
Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine m... |
DB01284 | DB10276 | 1,042 | 1,624 | [
"DDInter1782",
"DDInter1623"
] | Tetracosactide | Rotavirus vaccine | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Moderate | 1 | [
[
[
1042,
24,
1624
]
],
[
[
1042,
63,
1648
],
[
1648,
25,
1624
]
],
[
[
1042,
25,
375
],
[
375,
25,
1624
]
],
[
[
1042,
24,
270
],
[
270,
... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may lead to a major life threatening interaction when taken with Rotavirus vaccine
Tetracosactide may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizuma... |
DB00450 | DB00470 | 78 | 530 | [
"DDInter603",
"DDInter601"
] | Droperidol | Dronabinol | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
78,
24,
530
]
],
[
[
78,
24,
1614
],
[
1614,
40,
530
]
],
[
[
78,
21,
29118
],
[
29118,
60,
530
]
],
[
[
78,
63,
701
],
[
701,
2... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Droperidol (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Dronabinol (Compound)
Droperidol may cause a moderate interaction ... |
DB01024 | DB01112 | 1,096 | 665 | [
"DDInter1252",
"DDInter335"
] | Mycophenolic acid | Cefuroxime | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. | Moderate | 1 | [
[
[
1096,
24,
665
]
],
[
[
1096,
24,
1462
],
[
1462,
1,
665
]
],
[
[
1096,
63,
149
],
[
149,
40,
665
]
],
[
[
1096,
63,
1087
],
[
1087,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefditoren"
... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Cefuroxime (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembles Cefuro... |
DB01005 | DB01208 | 995 | 945 | [
"DDInter894",
"DDInter1705"
] | Hydroxyurea | Sparfloxacin | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
995,
23,
945
]
],
[
[
995,
62,
739
],
[
739,
1,
945
]
],
[
[
995,
23,
1539
],
[
1539,
1,
945
]
],
[
[
995,
21,
28787
],
[
28787,
... | [
[
[
"Hydroxyurea",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Hydroxyurea",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Hydroxyurea may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Hydroxyurea may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) resembles Sparfloxacin (Compou... |
DB00673 | DB09061 | 723 | 1,627 | [
"DDInter112",
"DDInter284"
] | Aprepitant | Cannabidiol | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Minor | 0 | [
[
[
723,
23,
1627
]
],
[
[
723,
24,
760
],
[
760,
62,
1627
]
],
[
[
723,
24,
609
],
[
609,
23,
1627
]
],
[
[
723,
63,
600
],
[
600,
... | [
[
[
"Aprepitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cannabidiol"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Cla... |
DB00845 | DB06176 | 1,490 | 1,342 | [
"DDInter406",
"DDInter1616"
] | Clofazimine | Romidepsin | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1490,
24,
1342
]
],
[
[
1490,
23,
112
],
[
112,
23,
1342
]
],
[
[
1490,
63,
485
],
[
485,
24,
1342
]
],
[
[
1490,
24,
1520
],
[
1520,
... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Clofazimine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Clofazimine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and P... |
DB00790 | DB01285 | 664 | 708 | [
"DDInter1431",
"DDInter445"
] | Perindopril | Corticotropin | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
664,
24,
708
]
],
[
[
664,
63,
245
],
[
245,
24,
708
]
],
[
[
664,
24,
170
],
[
170,
24,
708
]
],
[
[
664,
24,
1662
],
[
1662,
6... | [
[
[
"Perindopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Perindopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin an... |
DB00501 | DB14723 | 752 | 159 | [
"DDInter380",
"DDInter1026"
] | Cimetidine | Larotrectinib | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
752,
24,
159
]
],
[
[
752,
23,
222
],
[
222,
23,
159
]
],
[
[
752,
24,
479
],
[
479,
23,
159
]
],
[
[
752,
64,
1230
],
[
1230,
2... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepe... |
DB00284 | DB01224 | 1,647 | 623 | [
"DDInter11",
"DDInter1553"
] | Acarbose | Quetiapine | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1647,
24,
623
]
],
[
[
1647,
24,
695
],
[
695,
1,
623
]
],
[
[
1647,
21,
28681
],
[
28681,
60,
623
]
],
[
[
1647,
24,
1616
],
[
1616,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
"... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Acarbose (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Quetiapine (Compound)
Acarbose may cause a moderate intera... |
DB11581 | DB15091 | 1,456 | 676 | [
"DDInter1926",
"DDInter1901"
] | Venetoclax | Upadacitinib | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1456,
25,
676
]
],
[
[
1456,
63,
1430
],
[
1430,
24,
676
]
],
[
[
1456,
64,
1249
],
[
1249,
24,
676
]
],
[
[
1456,
25,
283
],
[
283,
... | [
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Venetoclax may lead to a major life threatening interaction when taken with Nafcillin and Nafcillin may ca... |
DB01112 | DB01377 | 665 | 1,283 | [
"DDInter335",
"DDInter1119"
] | Cefuroxime | Magnesium oxide | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
665,
24,
1283
]
],
[
[
665,
63,
1194
],
[
1194,
23,
1283
]
],
[
[
665,
40,
1024
],
[
1024,
63,
1283
]
],
[
[
665,
24,
286
],
[
286,
... | [
[
[
"Cefuroxime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Cefuroxime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
],
... | Cefuroxime may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Cefuroxime (Compound) resembles Cefpodoxime (Compound) and Cefpodoxime may cause a moderate interaction that ... |
DB00590 | DB01211 | 1,433 | 609 | [
"DDInter592",
"DDInter393"
] | Doxazosin | Clarithromycin | Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin]. Because of its long-lasting effects, doxazosin can be administered once a day. It is marketed by Pfi... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1433,
24,
609
]
],
[
[
1433,
6,
4973
],
[
4973,
45,
609
]
],
[
[
1433,
21,
28662
],
[
28662,
60,
609
]
],
[
[
1433,
40,
479
],
[
479,
... | [
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Doxazosin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Doxazosin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Doxazosin (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Doxazosin (Compound) resembles Donepezil (Compound) and Donepezil may cause a minor interaction that can limit c... |
DB08871 | DB12332 | 36 | 1,619 | [
"DDInter666",
"DDInter1626"
] | Eribulin | Rucaparib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
36,
24,
1619
]
],
[
[
36,
63,
112
],
[
112,
23,
1619
]
],
[
[
36,
63,
259
],
[
259,
24,
1619
]
],
[
[
36,
24,
151
],
[
151,
63,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonac... |
DB00661 | DB11718 | 122 | 927 | [
"DDInter1928",
"DDInter640"
] | Verapamil | Encorafenib | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
122,
25,
927
]
],
[
[
122,
63,
1324
],
[
1324,
24,
927
]
],
[
[
122,
24,
1491
],
[
1491,
24,
927
]
],
[
[
122,
25,
484
],
[
484,
... | [
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
"Troglitaz... | Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Mi... |
DB01166 | DB11730 | 477 | 351 | [
"DDInter379",
"DDInter1588"
] | Cilostazol | Ribociclib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
477,
25,
351
]
],
[
[
477,
62,
1247
],
[
1247,
23,
351
]
],
[
[
477,
63,
222
],
[
222,
23,
351
]
],
[
[
477,
25,
283
],
[
283,
6... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfam... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine a... |
DB01218 | DB01406 | 1,493 | 984 | [
"DDInter852",
"DDInter472"
] | Halofantrine | Danazol | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Major | 2 | [
[
[
1493,
25,
984
]
],
[
[
1493,
6,
8374
],
[
8374,
45,
984
]
],
[
[
1493,
7,
5998
],
[
5998,
46,
984
]
],
[
[
1493,
18,
2183
],
[
2183,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danazol"
]
],
[
[
"Halofantrine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Danazo... | Halofantrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Danazol (Compound)
Halofantrine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Danazol (Compound)
Halofantrine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Danazol (Compound)
Halofantrine (Com... |
DB00738 | DB01238 | 485 | 673 | [
"DDInter1420",
"DDInter118"
] | Pentamidine | Aripiprazole | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
485,
24,
673
]
],
[
[
485,
63,
827
],
[
827,
40,
673
]
],
[
[
485,
24,
1630
],
[
1630,
1,
673
]
],
[
[
485,
6,
7524
],
[
7524,
4... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Co... |
DB00361 | DB10315 | 134 | 1,137 | [
"DDInter1939",
"DDInter1127"
] | Vinorelbine | Measles virus vaccine live attenuated | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
134,
25,
1137
]
],
[
[
134,
64,
581
],
[
581,
25,
1137
]
],
[
[
134,
25,
384
],
[
384,
25,
1137
]
],
[
[
134,
63,
1101
],
[
1101,
... | [
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Vinorelbine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Vinorelbine may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may lead to... |
DB06292 | DB09100 | 549 | 320 | [
"DDInter474",
"DDInter1799"
] | Dapagliflozin | Thyroid, porcine | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
549,
24,
320
]
],
[
[
549,
63,
417
],
[
417,
23,
320
]
],
[
[
549,
62,
467
],
[
467,
23,
320
]
],
[
[
549,
63,
1144
],
[
1144,
2... | [
[
[
"Dapagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Dapagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
... | Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Dapagliflozin may cause a minor interaction that can limit clinical effects when taken with Simvastatin a... |
DB01126 | DB12267 | 1,260 | 1,476 | [
"DDInter611",
"DDInter233"
] | Dutasteride | Brigatinib | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1260,
24,
1476
]
],
[
[
1260,
63,
629
],
[
629,
24,
1476
]
],
[
[
1260,
24,
951
],
[
951,
24,
1476
]
],
[
[
1260,
24,
1619
],
[
1619,
... | [
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
... | Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbo... |
DB00902 | DB09034 | 104 | 1,313 | [
"DDInter1168",
"DDInter1733"
] | Methdilazine | Suvorexant | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
104,
24,
1313
]
],
[
[
104,
63,
530
],
[
530,
24,
1313
]
],
[
[
104,
24,
401
],
[
401,
24,
1313
]
],
[
[
104,
40,
820
],
[
820,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Suvorexant
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and ... |
DB00862 | DB04868 | 1,005 | 478 | [
"DDInter1918",
"DDInter1293"
] | Vardenafil | Nilotinib | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1005,
25,
478
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
478
]
],
[
[
1005,
21,
28963
],
[
28963,
60,
478
]
],
[
[
1005,
24,
112
],
[
112,
... | [
[
[
"Vardenafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Vardenafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Nilotini... | Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Vardenafil (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metroni... |
DB00726 | DB04837 | 1,164 | 649 | [
"DDInter1876",
"DDInter407"
] | Trimipramine | Clofedanol | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1164,
35,
649
]
],
[
[
1164,
35,
1376
],
[
1376,
24,
649
]
],
[
[
1164,
1,
21
],
[
21,
24,
649
]
],
[
[
1164,
1,
675
],
[
675,
4... | [
[
[
"Trimipramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Trimipramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interac... | Trimipramine (Compound) resembles Clofedanol (Compound) and
Trimipramine (Compound) resembles Diphenhydramine (Compound) and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases wh... |
DB00757 | DB06603 | 1,166 | 39 | [
"DDInter581",
"DDInter1387"
] | Dolasetron | Panobinostat | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1166,
25,
39
]
],
[
[
1166,
23,
1247
],
[
1247,
23,
39
]
],
[
[
1166,
24,
479
],
[
479,
23,
39
]
],
[
[
1166,
25,
336
],
[
336,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Dolasetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Dolasetron may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Dolasetron may cause a moderate interaction that could exacerbate diseases when taken with Donepezil a... |
DB01181 | DB01246 | 1,532 | 820 | [
"DDInter906",
"DDInter45"
] | Ifosfamide | Alimemazine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1532,
24,
820
]
],
[
[
1532,
63,
358
],
[
358,
24,
820
]
],
[
[
1532,
63,
104
],
[
104,
40,
820
]
],
[
[
1532,
63,
675
],
[
675,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
[... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and... |
DB00509 | DB00682 | 1,294 | 126 | [
"DDInter530",
"DDInter1951"
] | Dextrothyroxine | Warfarin | The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinate... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
1294,
24,
126
]
],
[
[
1294,
7,
2384
],
[
2384,
46,
126
]
],
[
[
1294,
40,
1152
],
[
1152,
24,
126
]
],
[
[
1294,
24,
1264
],
[
1264,
... | [
[
[
"Dextrothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Dextrothyroxine",
"{u} (Compound) upregulates {v} (Gene)",
"CDK6"
],
[
"CDK6",
"{u} (Gene) is upregulated by ... | Dextrothyroxine (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Warfarin (Compound)
Dextrothyroxine (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Dextrothyroxine may cause a moderate interaction... |
DB00470 | DB01174 | 530 | 697 | [
"DDInter601",
"DDInter1442"
] | Dronabinol | Phenobarbital | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
530,
24,
697
]
],
[
[
530,
24,
759
],
[
759,
1,
697
]
],
[
[
530,
63,
362
],
[
362,
1,
697
]
],
[
[
530,
63,
536
],
[
536,
40,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound... |
DB00476 | DB06822 | 109 | 802 | [
"DDInter608",
"DDInter1812"
] | Duloxetine | Tinzaparin | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Moderate | 1 | [
[
[
109,
24,
802
]
],
[
[
109,
25,
222
],
[
222,
24,
802
]
],
[
[
109,
40,
758
],
[
758,
24,
802
]
],
[
[
109,
63,
305
],
[
305,
24,... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
]
],
[
[
"Duloxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Duloxetine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Duloxetine (Compound) resembles Fluoxetine (Compound) and Fluoxetine may cause a moderate interaction that could exacerbate d... |
DB11837 | DB14840 | 1,297 | 861 | [
"DDInter1351",
"DDInter1601"
] | Osilodrostat | Ripretinib | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1297,
24,
861
]
],
[
[
1297,
64,
351
],
[
351,
24,
861
]
],
[
[
1297,
63,
353
],
[
353,
24,
861
]
],
[
[
1297,
24,
1017
],
[
1017,
... | [
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Osilodrostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Riboci... | Osilodrostat may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin ma... |
DB08880 | DB14762 | 1,510 | 994 | [
"DDInter1771",
"DDInter1602"
] | Teriflunomide | Risankizumab | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Major | 2 | [
[
[
1510,
25,
994
]
],
[
[
1510,
23,
1114
],
[
1114,
23,
994
]
],
[
[
1510,
62,
1461
],
[
1461,
23,
994
]
],
[
[
1510,
64,
4
],
[
4,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risankizumab"
]
],
[
[
"Teriflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zi... | Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Risankizumab
Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and V... |
DB00661 | DB08820 | 122 | 1,478 | [
"DDInter1928",
"DDInter997"
] | Verapamil | Ivacaftor | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Major | 2 | [
[
[
122,
25,
1478
]
],
[
[
122,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
122,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
122,
25,
1135
],
[
1135,... | [
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ivacaftor"... | Verapamil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Verapamil (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Verapamil may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor... |
DB01238 | DB01261 | 673 | 170 | [
"DDInter118",
"DDInter1679"
] | Aripiprazole | Sitagliptin | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
673,
24,
170
]
],
[
[
673,
6,
8374
],
[
8374,
45,
170
]
],
[
[
673,
21,
28850
],
[
28850,
60,
170
]
],
[
[
673,
24,
52
],
[
52,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Aripiprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Aripiprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sitagliptin (Compound)
Aripiprazole (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide... |
DB06273 | DB10795 | 980 | 221 | [
"DDInter1824",
"DDInter1486"
] | Tocilizumab | Poliovirus type 1 antigen (formaldehyde inactivated) | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
980,
24,
221
]
],
[
[
980,
24,
36
],
[
36,
24,
221
]
],
[
[
980,
64,
581
],
[
581,
24,
221
]
],
[
[
980,
63,
599
],
[
599,
24,
... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Tocilizumab may lead to a major life threatening interaction when taken w... |
DB05676 | DB06414 | 1,513 | 655 | [
"DDInter111",
"DDInter703"
] | Apremilast | Etravirine | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1513,
24,
655
]
],
[
[
1513,
63,
1101
],
[
1101,
23,
655
]
],
[
[
1513,
63,
1051
],
[
1051,
24,
655
]
],
[
[
1513,
24,
868
],
[
868,
... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Etravirine
Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and A... |
DB00005 | DB08879 | 1,057 | 632 | [
"DDInter687",
"DDInter173"
] | Etanercept | Belimumab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Major | 2 | [
[
[
1057,
25,
632
]
],
[
[
1057,
23,
1461
],
[
1461,
23,
632
]
],
[
[
1057,
23,
1114
],
[
1114,
62,
632
]
],
[
[
1057,
25,
713
],
[
713,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belimumab"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Belimumab
Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate ... |
DB00283 | DB00964 | 701 | 1,617 | [
"DDInter395",
"DDInter110"
] | Clemastine | Apraclonidine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Moderate | 1 | [
[
[
701,
24,
1617
]
],
[
[
701,
24,
1020
],
[
1020,
1,
1617
]
],
[
[
701,
24,
1084
],
[
1084,
40,
1617
]
],
[
[
701,
21,
28975
],
[
28975,... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Apraclonidine (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine and Lofexidine (Compound) resembles Apraclonidine (Compou... |
DB00099 | DB00773 | 440 | 896 | [
"DDInter735",
"DDInter702"
] | Filgrastim | Etoposide | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
440,
24,
896
]
],
[
[
440,
24,
147
],
[
147,
23,
896
]
],
[
[
440,
24,
1362
],
[
1362,
63,
896
]
],
[
[
440,
24,
322
],
[
322,
2... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Etoposide
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib ... |
DB00836 | DB04946 | 543 | 924 | [
"DDInter1088",
"DDInter907"
] | Loperamide | Iloperidone | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
543,
24,
924
]
],
[
[
543,
63,
1664
],
[
1664,
1,
924
]
],
[
[
543,
63,
1425
],
[
1425,
25,
924
]
],
[
[
543,
24,
519
],
[
519,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Cisapride and Cisapride may lead to a major life threatening inter... |
DB00222 | DB00584 | 245 | 610 | [
"DDInter825",
"DDInter638"
] | Glimepiride | Enalapril | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Moderate | 1 | [
[
[
245,
24,
610
]
],
[
[
245,
24,
743
],
[
743,
1,
610
]
],
[
[
245,
24,
954
],
[
954,
40,
610
]
],
[
[
245,
24,
1144
],
[
1144,
63... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril (Compound) resembles Enalapril (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Enalapril (Compound)
Gl... |
DB00388 | DB00491 | 1,636 | 127 | [
"DDInter1453",
"DDInter1217"
] | Phenylephrine | Miglitol | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
1636,
24,
127
]
],
[
[
1636,
21,
28792
],
[
28792,
60,
127
]
],
[
[
1636,
24,
320
],
[
320,
63,
127
]
],
[
[
1636,
63,
245
],
[
245,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Phenylephrine",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorde... | Phenylephrine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Miglitol (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Thyroid, porcine and Thyroid, porcine may cause a moderate interaction that c... |
DB00963 | DB13620 | 1,263 | 948 | [
"DDInter241",
"DDInter1499"
] | Bromfenac | Potassium gluconate | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Moderate | 1 | [
[
[
1263,
24,
948
]
],
[
[
1263,
24,
848
],
[
848,
24,
948
]
],
[
[
1263,
1,
831
],
[
831,
24,
948
]
],
[
[
1263,
63,
1512
],
[
1512,
... | [
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
... | Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium gluconate
Bromfenac (Compound) resembles Indomethacin (Compound) and Indomethacin may cause a moderate interaction t... |
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