drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00163 | DB00352 | 1,461 | 482 | [
"DDInter1943",
"DDInter1814"
] | Vitamin E | Tioguanine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Moderate | 1 | [
[
[
1461,
24,
482
]
],
[
[
1461,
62,
66
],
[
66,
24,
482
]
],
[
[
1461,
24,
869
],
[
869,
63,
482
]
],
[
[
1461,
24,
552
],
[
552,
2... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Efalizumab"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan m... |
DB01249 | DB06402 | 258 | 1,079 | [
"DDInter958",
"DDInter1756"
] | Iodixanol | Telavancin | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Major | 2 | [
[
[
258,
25,
1079
]
],
[
[
258,
64,
91
],
[
91,
1,
1079
]
],
[
[
258,
21,
28680
],
[
28680,
60,
1079
]
],
[
[
258,
64,
485
],
[
485,
... | [
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telavancin"
]
],
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vancomycin"
],
[
"Vancomycin",
"{u} (Co... | Iodixanol may lead to a major life threatening interaction when taken with Vancomycin and Vancomycin (Compound) resembles Telavancin (Compound)
Iodixanol (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telavancin (Compound)
Iodixanol may lead to a major life threatening interaction when taken w... |
DB00222 | DB13873 | 245 | 1,534 | [
"DDInter825",
"DDInter719"
] | Glimepiride | Fenofibric acid | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.[A32038,L128... | Moderate | 1 | [
[
[
245,
24,
1534
]
],
[
[
245,
63,
1685
],
[
1685,
24,
1534
]
],
[
[
245,
40,
959
],
[
959,
24,
1534
]
],
[
[
245,
24,
1144
],
[
1144,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibric acid"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin human"
]... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Fenofibric acid
Glimepiride (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction... |
DB06700 | DB08901 | 643 | 1,468 | [
"DDInter511",
"DDInter1492"
] | Desvenlafaxine | Ponatinib | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
643,
24,
1468
]
],
[
[
643,
63,
478
],
[
478,
24,
1468
]
],
[
[
643,
6,
8374
],
[
8374,
45,
1468
]
],
[
[
643,
21,
29024
],
[
29024,
... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
... | Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Desvenlafaxine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound)
Desvenlafaxine... |
DB00334 | DB00491 | 867 | 127 | [
"DDInter1326",
"DDInter1217"
] | Olanzapine | Miglitol | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
867,
24,
127
]
],
[
[
867,
24,
1491
],
[
1491,
63,
127
]
],
[
[
867,
1,
623
],
[
623,
63,
127
]
],
[
[
867,
63,
245
],
[
245,
24... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Miglitol
Olanzapine (Compound) resembles Quetiapine (Compound) and Quetiapine may cause a moderate interaction that could... |
DB01309 | DB06788 | 1,254 | 1,616 | [
"DDInter933",
"DDInter864"
] | Insulin glulisine | Histrelin | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
1254,
24,
1616
]
],
[
[
1254,
63,
1247
],
[
1247,
23,
1616
]
],
[
[
1254,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
1254,
24,
4
],
[
4,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazo... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01017 | DB01357 | 1,669 | 890 | [
"DDInter1224",
"DDInter1160"
] | Minocycline | Mestranol | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
1669,
24,
890
]
],
[
[
1669,
40,
1572
],
[
1572,
24,
890
]
],
[
[
1669,
63,
126
],
[
126,
24,
890
]
],
[
[
1669,
1,
1545
],
[
1545,
... | [
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Minocycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocycline",
"{u} may cause ... | Minocycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Mestranol
Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that ... |
DB00816 | DB00841 | 1,674 | 532 | [
"DDInter1346",
"DDInter577"
] | Orciprenaline | Dobutamine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Moderate | 1 | [
[
[
1674,
24,
532
]
],
[
[
1674,
24,
817
],
[
817,
40,
532
]
],
[
[
1674,
64,
1523
],
[
1523,
40,
532
]
],
[
[
1674,
24,
1052
],
[
1052,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Dobutamine (Compound)
Orciprenaline may lead to a major life threatening interaction when taken with Labetalol and Labetalol (Compound) resembles Dobutamine (Compound)
Orciprenaline m... |
DB08871 | DB09104 | 36 | 286 | [
"DDInter666",
"DDInter1118"
] | Eribulin | Magnesium hydroxide | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
36,
24,
286
]
],
[
[
36,
63,
820
],
[
820,
23,
286
]
],
[
[
36,
24,
1468
],
[
1468,
23,
286
]
],
[
[
36,
63,
859
],
[
859,
24,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Po... |
DB00030 | DB01285 | 1,685 | 708 | [
"DDInter934",
"DDInter445"
] | Insulin human | Corticotropin | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1685,
24,
708
]
],
[
[
1685,
24,
1674
],
[
1674,
23,
708
]
],
[
[
1685,
24,
245
],
[
245,
24,
708
]
],
[
[
1685,
24,
5
],
[
5,
6... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Glimepir... |
DB00175 | DB09122 | 681 | 1,613 | [
"DDInter1509",
"DDInter1409"
] | Pravastatin | Peginterferon beta-1a | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
681,
24,
1613
]
],
[
[
681,
24,
168
],
[
168,
24,
1613
]
],
[
[
681,
1,
1463
],
[
1463,
24,
1613
]
],
[
[
681,
25,
1668
],
[
1668,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
... | Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Pravastatin (Compound) resembles Lovastatin (Compound) and Lovastatin may cause a moderate interacti... |
DB00850 | DB01176 | 1,630 | 537 | [
"DDInter1432",
"DDInter453"
] | Perphenazine | Cyclizine | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1630,
24,
537
]
],
[
[
1630,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1630,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1630,
35,
104
],
[
104,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and C... |
DB01229 | DB09280 | 973 | 1,604 | [
"DDInter1377",
"DDInter1101"
] | Paclitaxel | Lumacaftor | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
973,
24,
1604
]
],
[
[
973,
24,
1060
],
[
1060,
62,
1604
]
],
[
[
973,
63,
671
],
[
671,
24,
1604
]
],
[
[
973,
24,
1468
],
[
1468,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
],
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enfortumab vedotin may cause a minor interaction that can limit clinical effects when taken with Lumacaftor
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Fluvast... |
DB00794 | DB09073 | 759 | 951 | [
"DDInter1521",
"DDInter1379"
] | Primidone | Palbociclib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
759,
25,
951
]
],
[
[
759,
25,
1476
],
[
1476,
63,
951
]
],
[
[
759,
24,
710
],
[
710,
63,
951
]
],
[
[
759,
24,
259
],
[
259,
2... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib",
"{u} ma... | Primidone may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Binimetinib may cause... |
DB00422 | DB01156 | 895 | 593 | [
"DDInter1189",
"DDInter252"
] | Methylphenidate | Bupropion | Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cogni... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
895,
25,
593
]
],
[
[
895,
6,
12523
],
[
12523,
45,
593
]
],
[
[
895,
10,
11601
],
[
11601,
49,
593
]
],
[
[
895,
21,
29491
],
[
29491... | [
[
[
"Methylphenidate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Methylphenidate",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Methylphenidate (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bupropion (Compound)
Methylphenidate (Compound) palliates attention deficit hyperactivity disorder (Disease) and attention deficit hyperactivity disorder (Disease) is palliated by Bupropion (Compound)
Methylphenidate (Compound) causes Dental c... |
DB00574 | DB01261 | 121 | 170 | [
"DDInter717",
"DDInter1679"
] | Fenfluramine | Sitagliptin | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
121,
24,
170
]
],
[
[
121,
24,
52
],
[
52,
62,
170
]
],
[
[
121,
63,
1179
],
[
1179,
24,
170
]
],
[
[
121,
24,
1674
],
[
1674,
2... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro a... |
DB01181 | DB09074 | 1,532 | 1,362 | [
"DDInter906",
"DDInter1327"
] | Ifosfamide | Olaparib | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1532,
24,
1362
]
],
[
[
1532,
63,
896
],
[
896,
24,
1362
]
],
[
[
1532,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
1532,
24,
385
],
[
385,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinum... |
DB00836 | DB11837 | 543 | 1,297 | [
"DDInter1088",
"DDInter1351"
] | Loperamide | Osilodrostat | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
543,
24,
1297
]
],
[
[
543,
24,
112
],
[
112,
23,
1297
]
],
[
[
543,
24,
1320
],
[
1320,
63,
1297
]
],
[
[
543,
24,
623
],
[
623,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and El... |
DB00976 | DB11718 | 1,056 | 927 | [
"DDInter1758",
"DDInter640"
] | Telithromycin | Encorafenib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
1056,
25,
927
]
],
[
[
1056,
62,
112
],
[
112,
23,
927
]
],
[
[
1056,
24,
720
],
[
720,
24,
927
]
],
[
[
1056,
63,
372
],
[
372,
... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Telithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Me... | Telithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil ... |
DB00686 | DB06779 | 383 | 365 | [
"DDInter1424",
"DDInter470"
] | Pentosan polysulfate | Dalteparin | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
383,
24,
365
]
],
[
[
383,
24,
1496
],
[
1496,
63,
365
]
],
[
[
383,
24,
765
],
[
765,
24,
365
]
],
[
[
383,
63,
1018
],
[
1018,
... | [
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ninteda... | Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with H... |
DB00615 | DB08916 | 690 | 26 | [
"DDInter1589",
"DDInter32"
] | Rifabutin | Afatinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
690,
24,
26
]
],
[
[
690,
63,
883
],
[
883,
40,
26
]
],
[
[
690,
7,
14278
],
[
14278,
45,
26
]
],
[
[
690,
18,
2183
],
[
2183,
5... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Rifabutin (Compound) upregulates PHKG2 (Gene) and PHKG2 (Gene) is bound by Afatinib (Compound)
Rifabutin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is do... |
DB00175 | DB00188 | 681 | 168 | [
"DDInter1509",
"DDInter222"
] | Pravastatin | Bortezomib | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Moderate | 1 | [
[
[
681,
24,
168
]
],
[
[
681,
6,
6017
],
[
6017,
45,
168
]
],
[
[
681,
7,
7273
],
[
7273,
46,
168
]
],
[
[
681,
6,
8559
],
[
8559,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
]
],
[
[
"Pravastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Pravastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bortezomib (Compound)
Pravastatin (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Bortezomib (Compound)
Pravastatin (Compound) binds HMGCR (Gene) and HMGCR (Gene) is upregulated by Bortezomib (Compound)
Pravastatin (Comp... |
DB09420 | DB12834 | 1,074 | 148 | [
"DDInter953",
"DDInter1649"
] | Iodide I-123 | Secnidazole | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1074,
24,
148
]
],
[
[
1074,
24,
1434
],
[
1434,
24,
148
]
],
[
[
1074,
63,
458
],
[
458,
24,
148
]
],
[
[
1074,
24,
1434
],
[
1434,
... | [
[
[
"Iodide I-123",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Iodide I-123",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
],
... | Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole and Benznidazole may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole a... |
DB00445 | DB08899 | 322 | 129 | [
"DDInter655",
"DDInter649"
] | Epirubicin | Enzalutamide | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
322,
24,
129
]
],
[
[
322,
24,
918
],
[
918,
1,
129
]
],
[
[
322,
21,
29377
],
[
29377,
60,
129
]
],
[
[
322,
23,
1247
],
[
1247,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Epirubicin (Compound) causes Musculoskeletal pain (Side Effect) and Musculoskeletal pain (Side Effect) is caused by Enzalutamide (Compound)
Epirubicin may... |
DB01045 | DB01129 | 463 | 379 | [
"DDInter1590",
"DDInter1559"
] | Rifampicin | Rabeprazole | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Moderate | 1 | [
[
[
463,
24,
379
]
],
[
[
463,
63,
1215
],
[
1215,
40,
379
]
],
[
[
463,
63,
660
],
[
660,
1,
379
]
],
[
[
463,
6,
8374
],
[
8374,
4... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole (... |
DB00209 | DB00376 | 352 | 1,105 | [
"DDInter1886",
"DDInter1870"
] | Trospium | Trihexyphenidyl | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Moderate | 1 | [
[
[
352,
24,
1105
]
],
[
[
352,
40,
11264
],
[
11264,
40,
1105
]
],
[
[
352,
24,
456
],
[
456,
1,
1105
]
],
[
[
352,
24,
1386
],
[
1386,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
]
],
[
[
"Trospium",
"{u} (Compound) resembles {v} (Compound)",
"Diphenidol"
],
[
"Diphenidol",
"{u} (Compound) resembl... | Trospium (Compound) resembles Diphenidol (Compound) and Diphenidol (Compound) resembles Trihexyphenidyl (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Biperiden and Biperiden (Compound) resembles Trihexyphenidyl (Compound)
Trospium may cause a moderate interaction th... |
DB00836 | DB11915 | 543 | 1,293 | [
"DDInter1088",
"DDInter1909"
] | Loperamide | Valbenazine | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
543,
24,
1293
]
],
[
[
543,
24,
112
],
[
112,
23,
1293
]
],
[
[
543,
63,
521
],
[
521,
24,
1293
]
],
[
[
543,
24,
516
],
[
516,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Go... |
DB01069 | DB09104 | 401 | 286 | [
"DDInter1533",
"DDInter1118"
] | Promethazine | Magnesium hydroxide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
401,
23,
286
]
],
[
[
401,
24,
481
],
[
481,
23,
286
]
],
[
[
401,
63,
1119
],
[
1119,
23,
286
]
],
[
[
401,
24,
859
],
[
859,
2... | [
[
[
"Promethazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
],... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Quazepam and Quazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxi... |
DB00222 | DB01268 | 245 | 1,151 | [
"DDInter825",
"DDInter1731"
] | Glimepiride | Sunitinib | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
245,
24,
1151
]
],
[
[
245,
21,
29269
],
[
29269,
60,
1151
]
],
[
[
245,
24,
1247
],
[
1247,
23,
1151
]
],
[
[
245,
24,
655
],
[
655,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Menopausal symptoms"
],
[
"Menopausal symptoms",
"{u} ... | Glimepiride (Compound) causes Menopausal symptoms (Side Effect) and Menopausal symptoms (Side Effect) is caused by Sunitinib (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical ... |
DB00712 | DB00722 | 1,274 | 743 | [
"DDInter763",
"DDInter1079"
] | Flurbiprofen | Lisinopril | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Moderate | 1 | [
[
[
1274,
24,
743
]
],
[
[
1274,
63,
610
],
[
610,
40,
743
]
],
[
[
1274,
24,
954
],
[
954,
40,
743
]
],
[
[
1274,
63,
1638
],
[
1638,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Lisinopril (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Lisinopril (Compound)
... |
DB00363 | DB00773 | 695 | 896 | [
"DDInter419",
"DDInter702"
] | Clozapine | Etoposide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Major | 2 | [
[
[
695,
25,
896
]
],
[
[
695,
6,
3486
],
[
3486,
45,
896
]
],
[
[
695,
18,
17366
],
[
17366,
57,
896
]
],
[
[
695,
25,
147
],
[
147,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etoposide"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Etoposide"... | Clozapine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Etoposide (Compound)
Clozapine (Compound) downregulates C2CD5 (Gene) and C2CD5 (Gene) is downregulated by Etoposide (Compound)
Clozapine may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may cause a minor i... |
DB00275 | DB00761 | 217 | 1,621 | [
"DDInter1330",
"DDInter1497"
] | Olmesartan | Potassium chloride | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
217,
25,
1621
]
],
[
[
217,
21,
28809
],
[
28809,
60,
1621
]
],
[
[
217,
63,
1685
],
[
1685,
23,
1621
]
],
[
[
217,
24,
1254
],
[
1254... | [
[
[
"Olmesartan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Olmesartan",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caused by {... | Olmesartan (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)
Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Insulin human may cause a minor interaction that can limit clinical effects when taken ... |
DB01583 | DB11093 | 624 | 636 | [
"DDInter1075",
"DDInter273"
] | Liotrix | Calcium citrate | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
624,
24,
636
]
],
[
[
624,
1,
542
],
[
542,
24,
636
]
],
[
[
624,
40,
1152
],
[
1152,
24,
636
]
],
[
[
624,
63,
1231
],
[
1231,
... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Liotrix",
"{u} (Compound) resembles {v} (Compound)",
"Levothyroxine"
],
[
"Levothyroxine",
"{u} may cause a mo... | Liotrix (Compound) resembles Levothyroxine (Compound) and Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Liotrix (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Ca... |
DB00059 | DB01083 | 1,560 | 1,142 | [
"DDInter1404",
"DDInter1348"
] | Pegaspargase | Orlistat | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Moderate | 1 | [
[
[
1560,
24,
1142
]
],
[
[
1560,
24,
5
],
[
5,
63,
1142
]
],
[
[
1560,
24,
45
],
[
45,
24,
1142
]
],
[
[
1560,
63,
176
],
[
176,
24... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide and Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Orlistat
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Di... |
DB06704 | DB09498 | 247 | 810 | [
"DDInter952",
"DDInter1715"
] | Iobenguane (I-131) | Strontium chloride Sr-89 | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
247,
24,
810
]
],
[
[
247,
63,
139
],
[
139,
24,
810
]
],
[
[
247,
24,
1186
],
[
1186,
24,
810
]
],
[
[
247,
64,
695
],
[
695,
2... | [
[
[
"Iobenguane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Iobenguane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
... | Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Stronti... |
DB00852 | DB06292 | 1,445 | 549 | [
"DDInter1545",
"DDInter474"
] | Pseudoephedrine | Dapagliflozin | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1445,
24,
549
]
],
[
[
1445,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1445,
6,
12523
],
[
12523,
45,
549
]
],
[
[
1445,
21,
28882
],
[
288... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"... | Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Pseudoephedrine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dapagliflozin (Compound)
Pseudoephedrine (Compound) causes Body tempe... |
DB06699 | DB12161 | 774 | 730 | [
"DDInter493",
"DDInter512"
] | Degarelix | Deutetrabenazine | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
774,
24,
730
]
],
[
[
774,
62,
112
],
[
112,
23,
730
]
],
[
[
774,
63,
322
],
[
322,
24,
730
]
],
[
[
774,
24,
971
],
[
971,
24,... | [
[
[
"Degarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Degarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Degarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and ... |
DB01377 | DB08901 | 1,283 | 1,468 | [
"DDInter1119",
"DDInter1492"
] | Magnesium oxide | Ponatinib | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Minor | 0 | [
[
[
1283,
23,
1468
]
],
[
[
1283,
24,
478
],
[
478,
24,
1468
]
],
[
[
1283,
62,
1194
],
[
1194,
23,
1468
]
],
[
[
1283,
24,
460
],
[
460,
... | [
[
[
"Magnesium oxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ponatinib"
]
],
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
... | Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Ranitidine and R... |
DB06168 | DB14881 | 1,531 | 180 | [
"DDInter281",
"DDInter1329"
] | Canakinumab | Oliceridine | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
1531,
24,
180
]
],
[
[
1531,
63,
1184
],
[
1184,
24,
180
]
],
[
[
1531,
24,
36
],
[
36,
24,
180
]
],
[
[
1531,
25,
980
],
[
980,
... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anakinra"
],
[
... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin ... |
DB00026 | DB05015 | 1,184 | 1,077 | [
"DDInter94",
"DDInter174"
] | Anakinra | Belinostat | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Moderate | 1 | [
[
[
1184,
24,
1077
]
],
[
[
1184,
24,
482
],
[
482,
24,
1077
]
],
[
[
1184,
24,
1136
],
[
1136,
63,
1077
]
],
[
[
1184,
63,
305
],
[
305,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belinostat"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Belinostat
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Denosumab and Denosumab m... |
DB00370 | DB01177 | 1,251 | 77 | [
"DDInter1230",
"DDInter904"
] | Mirtazapine | Idarubicin | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1251,
24,
77
]
],
[
[
1251,
6,
6017
],
[
6017,
45,
77
]
],
[
[
1251,
18,
10699
],
[
10699,
57,
77
]
],
[
[
1251,
21,
28987
],
[
28987,... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Mirtazapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Mirtazapine (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Idarubicin (Compound)
Mirtazapine (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Idarubicin (Compound)
Mir... |
DB00563 | DB01045 | 663 | 463 | [
"DDInter1174",
"DDInter1590"
] | Methotrexate | Rifampicin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
663,
24,
463
]
],
[
[
663,
6,
5912
],
[
5912,
45,
463
]
],
[
[
663,
63,
1101
],
[
1101,
23,
463
]
],
[
[
663,
24,
1228
],
[
1228,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)... | Methotrexate (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Rifampicin (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Rifampicin
Methotrexate may c... |
DB00468 | DB12245 | 1,424 | 823 | [
"DDInter1557",
"DDInter1863"
] | Quinine | Triclabendazole | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1424,
24,
823
]
],
[
[
1424,
23,
1247
],
[
1247,
23,
823
]
],
[
[
1424,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1424,
63,
1010
],
[
1010,... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Quinine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[... | Quinine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir an... |
DB04946 | DB11963 | 924 | 1,045 | [
"DDInter907",
"DDInter465"
] | Iloperidone | Dacomitinib | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Major | 2 | [
[
[
924,
25,
1045
]
],
[
[
924,
40,
1664
],
[
1664,
24,
1045
]
],
[
[
924,
63,
1376
],
[
1376,
24,
1045
]
],
[
[
924,
25,
384
],
[
384,
... | [
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dacomitinib"
]
],
[
[
"Iloperidone",
"{u} (Compound) resembles {v} (Compound)",
"Risperidone"
],
[
"Risperidone",
"{u} may cause a moderate interact... | Iloperidone (Compound) resembles Risperidone (Compound) and Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interac... |
DB01284 | DB09473 | 1,042 | 884 | [
"DDInter1782",
"DDInter918"
] | Tetracosactide | Indium In-111 oxyquinoline | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
1042,
24,
884
]
],
[
[
1042,
63,
1648
],
[
1648,
24,
884
]
],
[
[
1042,
63,
1680
],
[
1680,
62,
1572
],
[
1572,
24,
884
]
],
[
[
1042,... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ald... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01045 | DB06603 | 463 | 39 | [
"DDInter1590",
"DDInter1387"
] | Rifampicin | Panobinostat | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
463,
25,
39
]
],
[
[
463,
63,
112
],
[
112,
23,
39
]
],
[
[
463,
63,
912
],
[
912,
24,
39
]
],
[
[
463,
25,
578
],
[
578,
63,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metro... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta... |
DB00812 | DB08882 | 998 | 1,281 | [
"DDInter1451",
"DDInter1070"
] | Phenylbutazone | Linagliptin | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
998,
24,
1281
]
],
[
[
998,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
998,
63,
251
],
[
251,
24,
1281
]
],
[
[
998,
1,
651
],
[
651,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Phenylbutazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin
Ph... |
DB08903 | DB12001 | 996 | 564 | [
"DDInter170",
"DDInter7"
] | Bedaquiline | Abemaciclib | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
996,
24,
564
]
],
[
[
996,
63,
1051
],
[
1051,
24,
564
]
],
[
[
996,
64,
868
],
[
868,
24,
564
]
],
[
[
996,
25,
982
],
[
982,
6... | [
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
]... | Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Bedaquiline may lead to a major life threatening interaction when taken with Vemurafenib and Vem... |
DB01193 | DB06705 | 819 | 1,106 | [
"DDInter12",
"DDInter795"
] | Acebutolol | Gadofosveset trisodium | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Gadofosveset trisodium is an intravenous contrast agent used with magnetic resonance angiography(MRA), which is a non-invasive way of imaging blood vessels. The agent allows for the vascular system to be imaged more clearly by the MRA. In this way, gadofosveset trisodium is used to help diagnose certain disorders of th... | Moderate | 1 | [
[
[
819,
24,
1106
]
],
[
[
819,
63,
457
],
[
457,
40,
1106
]
],
[
[
819,
24,
796
],
[
796,
40,
1106
]
],
[
[
819,
21,
29209
],
[
29209,
... | [
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadofosveset trisodium"
]
],
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadodiamide"
... | Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Gadodiamide and Gadodiamide (Compound) resembles Gadofosveset trisodium (Compound)
Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Gadoxetic acid and Gadoxetic acid (Compound) resembles ... |
DB00252 | DB01377 | 362 | 1,283 | [
"DDInter1460",
"DDInter1119"
] | Phenytoin | Magnesium oxide | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
362,
24,
1283
]
],
[
[
362,
24,
167
],
[
167,
23,
1283
]
],
[
[
362,
24,
1468
],
[
1468,
62,
1283
]
],
[
[
362,
25,
263
],
[
263,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib an... |
DB02701 | DB14761 | 1,632 | 242 | [
"DDInter1289",
"DDInter1578"
] | Nicotinamide | Remdesivir | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1632,
24,
242
]
],
[
[
1632,
63,
1130
],
[
1130,
24,
242
]
],
[
[
1632,
64,
1377
],
[
1377,
24,
242
]
],
[
[
1632,
24,
384
],
[
384,
... | [
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
... | Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Nicotinamide may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide ... |
DB06237 | DB12332 | 438 | 1,619 | [
"DDInter141",
"DDInter1626"
] | Avanafil | Rucaparib | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
438,
24,
1619
]
],
[
[
438,
64,
1419
],
[
1419,
24,
1619
]
],
[
[
438,
24,
159
],
[
159,
63,
1619
]
],
[
[
438,
24,
913
],
[
913,
... | [
[
[
"Avanafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Avanafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Imatinib"
],
[
"Imatinib",
... | Avanafil may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Avanafil may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a m... |
DB09030 | DB15233 | 840 | 1,650 | [
"DDInter1945",
"DDInter142"
] | Vorapaxar | Avapritinib | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
840,
25,
1650
]
],
[
[
840,
24,
159
],
[
159,
24,
1650
]
],
[
[
840,
63,
557
],
[
557,
24,
1650
]
],
[
[
840,
64,
1512
],
[
1512,
... | [
[
[
"Vorapaxar",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Vorapaxar",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
"Larotrec... | Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid... |
DB01072 | DB11703 | 915 | 405 | [
"DDInter129",
"DDInter9"
] | Atazanavir | Acalabrutinib | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
915,
25,
405
]
],
[
[
915,
24,
1384
],
[
1384,
24,
405
]
],
[
[
915,
63,
1051
],
[
1051,
24,
405
]
],
[
[
915,
25,
951
],
[
951,
... | [
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
],
[
"Magaldr... | Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide ... |
DB00308 | DB00539 | 347 | 11 | [
"DDInter901",
"DDInter1837"
] | Ibutilide | Toremifene | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
347,
25,
11
]
],
[
[
347,
24,
1376
],
[
1376,
40,
11
]
],
[
[
347,
21,
28722
],
[
28722,
60,
11
]
],
[
[
347,
23,
112
],
[
112,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Ibutilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
"Diphenh... | Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Toremifene (Compound)
Ibutilide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Toremifene (Compound)
Ibutilide may cause a minor interaction th... |
DB08868 | DB09312 | 1,011 | 967 | [
"DDInter737",
"DDInter103"
] | Fingolimod | Antilymphocyte immunoglobulin (horse) | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The... | Major | 2 | [
[
[
1011,
64,
967
]
],
[
[
1011,
64,
1683
],
[
1683,
24,
967
]
],
[
[
1011,
64,
1531
],
[
1531,
63,
967
]
],
[
[
1011,
25,
270
],
[
270,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Antilymphocyte immunoglobulin (horse)"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ustekinumab"
],
[
... | Fingolimod may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Antilymphocyte immunoglobulin (horse)
Fingolimod may lead to a major life threatening interaction when taken with Canakinumab and Canaki... |
DB00182 | DB06723 | 80 | 115 | [
"DDInter84",
"DDInter58"
] | Amphetamine | Aluminum hydroxide | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
80,
24,
115
]
],
[
[
80,
21,
28643
],
[
28643,
60,
115
]
],
[
[
80,
24,
401
],
[
401,
23,
115
]
],
[
[
80,
40,
93
],
[
93,
24,
... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Amphetamine",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Effec... | Amphetamine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken ... |
DB01009 | DB01234 | 935 | 1,220 | [
"DDInter1009",
"DDInter513"
] | Ketoprofen | Dexamethasone | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
935,
24,
1220
]
],
[
[
935,
63,
870
],
[
870,
1,
1220
]
],
[
[
935,
63,
175
],
[
175,
40,
1220
]
],
[
[
935,
24,
617
],
[
617,
4... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dex... |
DB03128 | DB04843 | 140 | 1,511 | [
"DDInter18",
"DDInter1149"
] | Acetylcholine | Mepenzolate | A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken ... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
140,
24,
1511
]
],
[
[
140,
63,
537
],
[
537,
24,
1511
]
],
[
[
140,
24,
1429
],
[
1429,
63,
1511
]
],
[
[
140,
63,
701
],
[
701,
... | [
[
[
"Acetylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Acetylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Acetylcholine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Acetylcholine may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium and A... |
DB00889 | DB01105 | 1,133 | 222 | [
"DDInter840",
"DDInter1665"
] | Granisetron | Sibutramine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Major | 2 | [
[
[
1133,
25,
222
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
222
]
],
[
[
1133,
18,
7359
],
[
7359,
57,
222
]
],
[
[
1133,
21,
28852
],
[
28852... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Sibu... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Granisetron (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Sibutramine (Compound)
Granisetron (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutramine (Co... |
DB01177 | DB11988 | 77 | 270 | [
"DDInter904",
"DDInter1321"
] | Idarubicin | Ocrelizumab | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
77,
24,
270
]
],
[
[
77,
63,
1461
],
[
1461,
23,
270
]
],
[
[
77,
63,
134
],
[
134,
24,
270
]
],
[
[
77,
24,
1491
],
[
1491,
24,... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelb... |
DB00445 | DB09122 | 322 | 1,613 | [
"DDInter655",
"DDInter1409"
] | Epirubicin | Peginterferon beta-1a | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
322,
24,
1613
]
],
[
[
322,
24,
671
],
[
671,
24,
1613
]
],
[
[
322,
24,
975
],
[
975,
63,
1613
]
],
[
[
322,
63,
600
],
[
600,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Lurbinec... |
DB00078 | DB10989 | 1,172 | 496 | [
"DDInter898",
"DDInter858"
] | Ibritumomab tiuxetan | Hepatitis A Vaccine | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
1172,
24,
496
]
],
[
[
1172,
25,
4
],
[
4,
24,
496
]
],
[
[
1172,
24,
738
],
[
738,
63,
496
]
],
[
[
1172,
24,
869
],
[
869,
24,... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine m... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate di... |
DB01050 | DB06822 | 848 | 802 | [
"DDInter900",
"DDInter1812"
] | Ibuprofen | Tinzaparin | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
848,
25,
802
]
],
[
[
848,
23,
297
],
[
297,
62,
802
]
],
[
[
848,
24,
222
],
[
222,
24,
802
]
],
[
[
848,
63,
758
],
[
758,
24,... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Ibuprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} ... | Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Tinzaparin
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause... |
DB00747 | DB01359 | 1,442 | 729 | [
"DDInter1647",
"DDInter1417"
] | Scopolamine | Penbutolol | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
1442,
24,
729
]
],
[
[
1442,
63,
461
],
[
461,
1,
729
]
],
[
[
1442,
24,
699
],
[
699,
40,
729
]
],
[
[
1442,
21,
28762
],
[
28762,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Scopolamin... |
DB00063 | DB05578 | 366 | 330 | [
"DDInter659",
"DDInter1566"
] | Eptifibatide | Ramucirumab | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
366,
25,
330
]
],
[
[
366,
24,
41
],
[
41,
63,
330
]
],
[
[
366,
24,
901
],
[
901,
24,
330
]
],
[
[
366,
25,
1317
],
[
1317,
25,... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
"... | Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Milnac... |
DB00038 | DB01181 | 186 | 1,532 | [
"DDInter1345",
"DDInter906"
] | Oprelvekin | Ifosfamide | Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which ... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Major | 2 | [
[
[
186,
25,
1532
]
],
[
[
186,
25,
350
],
[
350,
21,
29209
],
[
29209,
60,
1532
]
],
[
[
186,
25,
350
],
[
350,
24,
1330
],
[
1330,
63,... | [
[
[
"Oprelvekin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ifosfamide"
]
],
[
[
"Oprelvekin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
],
[
"Carfilzomib",
"{u}... | Oprelvekin may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Oprelvekin may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib may cause... |
DB00365 | DB01128 | 839 | 918 | [
"DDInter842",
"DDInter204"
] | Grepafloxacin | Bicalutamide | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Major | 2 | [
[
[
839,
25,
918
]
],
[
[
839,
25,
129
],
[
129,
40,
918
]
],
[
[
839,
23,
112
],
[
112,
23,
918
]
],
[
[
839,
25,
126
],
[
126,
23,... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Grepafloxacin may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can lim... |
DB00041 | DB00321 | 1,648 | 21 | [
"DDInter38",
"DDInter78"
] | Aldesleukin | Amitriptyline | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Moderate | 1 | [
[
[
1648,
24,
21
]
],
[
[
1648,
24,
1237
],
[
1237,
40,
21
]
],
[
[
1648,
24,
1164
],
[
1164,
1,
21
]
],
[
[
1648,
24,
537
],
[
537,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amitriptyline"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Amitriptyline (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Amitripty... |
DB00539 | DB12332 | 11 | 1,619 | [
"DDInter1837",
"DDInter1626"
] | Toremifene | Rucaparib | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
11,
25,
1619
]
],
[
[
11,
24,
307
],
[
307,
23,
1619
]
],
[
[
11,
23,
112
],
[
112,
23,
1619
]
],
[
[
11,
25,
87
],
[
87,
24,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
"Modafinil",
... | Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Toremifene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidaz... |
DB00041 | DB00295 | 1,648 | 475 | [
"DDInter38",
"DDInter1244"
] | Aldesleukin | Morphine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Moderate | 1 | [
[
[
1648,
24,
475
]
],
[
[
1648,
24,
421
],
[
421,
64,
475
]
],
[
[
1648,
24,
122
],
[
122,
62,
475
]
],
[
[
1648,
24,
1269
],
[
1269,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
],
[... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone may lead to a major life threatening interaction when taken with Morphine
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may ca... |
DB00468 | DB00877 | 1,424 | 629 | [
"DDInter1557",
"DDInter1678"
] | Quinine | Sirolimus | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1424,
24,
629
]
],
[
[
1424,
6,
4973
],
[
4973,
45,
629
]
],
[
[
1424,
7,
5998
],
[
5998,
46,
629
]
],
[
[
1424,
21,
29276
],
[
29276,... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"S... | Quinine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Quinine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Sirolimus (Compound)
Quinine (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Sirolimus (Compound)
Quinine may caus... |
DB00880 | DB01142 | 359 | 1,264 | [
"DDInter360",
"DDInter593"
] | Chlorothiazide | Doxepin | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
359,
24,
1264
]
],
[
[
359,
24,
401
],
[
401,
24,
1264
]
],
[
[
359,
21,
28898
],
[
28898,
60,
1264
]
],
[
[
359,
40,
504
],
[
504,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Chlorothiazide (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Dox... |
DB00622 | DB06292 | 1,081 | 549 | [
"DDInter1287",
"DDInter474"
] | Nicardipine | Dapagliflozin | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1081,
24,
549
]
],
[
[
1081,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1081,
6,
8374
],
[
8374,
45,
549
]
],
[
[
1081,
21,
28882
],
[
28882... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Nicardipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Nicardipine (Compound) causes Body temperature incre... |
DB11560 | DB14723 | 1,678 | 159 | [
"DDInter1038",
"DDInter1026"
] | Lesinurad | Larotrectinib | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1678,
24,
159
]
],
[
[
1678,
24,
466
],
[
466,
23,
159
]
],
[
[
1678,
63,
11
],
[
11,
24,
159
]
],
[
[
1678,
24,
1619
],
[
1619,
... | [
[
[
"Lesinurad",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Lesinurad",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Tor... |
DB00635 | DB00683 | 1,573 | 1,382 | [
"DDInter1515",
"DDInter1212"
] | Prednisone | Midazolam | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Minor | 0 | [
[
[
1573,
23,
1382
]
],
[
[
1573,
62,
523
],
[
523,
40,
1382
]
],
[
[
1573,
6,
8374
],
[
8374,
45,
1382
]
],
[
[
1573,
21,
28883
],
[
2888... | [
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Midazolam"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alprazolam"
],
[
"... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Alprazolam and Alprazolam (Compound) resembles Midazolam (Compound)
Prednisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Midazolam (Compound)
Prednisone (Compound) causes Skin disorder (Side Effect) and Skin diso... |
DB00912 | DB06210 | 473 | 72 | [
"DDInter1581",
"DDInter631"
] | Repaglinide | Eltrombopag | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
473,
24,
72
]
],
[
[
473,
6,
3486
],
[
3486,
45,
72
]
],
[
[
473,
24,
74
],
[
74,
62,
72
]
],
[
[
473,
24,
384
],
[
384,
63,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Repaglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Repaglinide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Eltrombopag (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Boceprevir and Boceprevir may cause a minor interaction that can limit clinical effects when taken with Eltrombopag
Repaglinide may ... |
DB00382 | DB09080 | 62 | 144 | [
"DDInter1734",
"DDInter1331"
] | Tacrine | Olodaterol | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
62,
24,
144
]
],
[
[
62,
24,
1011
],
[
1011,
24,
144
]
],
[
[
62,
63,
600
],
[
600,
24,
144
]
],
[
[
62,
24,
823
],
[
823,
63,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
],
[
"F... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole... |
DB00252 | DB00468 | 362 | 1,424 | [
"DDInter1460",
"DDInter1557"
] | Phenytoin | Quinine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Moderate | 1 | [
[
[
362,
24,
1424
]
],
[
[
362,
6,
21998
],
[
21998,
45,
1424
]
],
[
[
362,
21,
29316
],
[
29316,
60,
1424
]
],
[
[
362,
40,
307
],
[
307,... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by {v}... | Phenytoin (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Quinine (Compound)
Phenytoin (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Quinine (Compound)
Phenytoin (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that c... |
DB00421 | DB06292 | 443 | 549 | [
"DDInter1707",
"DDInter474"
] | Spironolactone | Dapagliflozin | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
443,
24,
549
]
],
[
[
443,
24,
1344
],
[
1344,
40,
549
]
],
[
[
443,
6,
4973
],
[
4973,
45,
549
]
],
[
[
443,
21,
28882
],
[
28882,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Spironolactone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dapagliflozin (Compound)
Spironolactone (Compound) causes Body temperatur... |
DB00041 | DB00443 | 1,648 | 251 | [
"DDInter38",
"DDInter195"
] | Aldesleukin | Betamethasone | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
1648,
24,
251
]
],
[
[
1648,
24,
617
],
[
617,
40,
251
]
],
[
[
1648,
24,
167
],
[
167,
1,
251
]
],
[
[
1648,
24,
1382
],
[
1382,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Betamethasone (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Betametha... |
DB00631 | DB00951 | 372 | 1,072 | [
"DDInter405",
"DDInter986"
] | Clofarabine | Isoniazid | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
372,
24,
1072
]
],
[
[
372,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
372,
24,
1130
],
[
1130,
63,
1072
]
],
[
[
372,
63,
912
],
[
912,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Clofarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by... | Clofarabine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Isoniazi... |
DB08880 | DB10583 | 1,510 | 949 | [
"DDInter1771",
"DDInter415"
] | Teriflunomide | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1510,
24,
949
]
],
[
[
1510,
64,
550
],
[
550,
24,
949
]
],
[
[
1510,
25,
250
],
[
250,
24,
949
]
],
[
[
1510,
25,
1093
],
[
1093,
... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with... | Teriflunomide may lead to a major life threatening interaction when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Teriflunomide may lead to a major life threatening interaction when take... |
DB00372 | DB01020 | 999 | 1,107 | [
"DDInter1793",
"DDInter990"
] | Thiethylperazine | Isosorbide mononitrate | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of [isosorbide dinitrate]. Li... | Moderate | 1 | [
[
[
999,
24,
1107
]
],
[
[
999,
24,
426
],
[
426,
40,
1107
]
],
[
[
999,
24,
407
],
[
407,
63,
1107
]
],
[
[
999,
24,
530
],
[
530,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isosorbide mononitrate"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iso... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide dinitrate and Isosorbide dinitrate (Compound) resembles Isosorbide mononitrate (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause... |
DB01403 | DB06704 | 9 | 247 | [
"DDInter1175",
"DDInter951"
] | Methotrimeprazine | Iobenguane (I-123) | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
9,
24,
247
]
],
[
[
9,
18,
7359
],
[
7359,
57,
247
]
],
[
[
9,
21,
28681
],
[
28681,
60,
247
]
],
[
[
9,
1,
820
],
[
820,
24,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Methotrimeprazine",
"{u} (Compound) downregulates {v} (Gene)",
"TXNDC9"
],
[
"TXNDC9",
"{u} (Gene) is dow... | Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Methotrimeprazine (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Iobenguane (Compound)
Methotrimeprazine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side ... |
DB01041 | DB01148 | 770 | 1,128 | [
"DDInter1789",
"DDInter738"
] | Thalidomide | Flavoxate | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem] | Moderate | 1 | [
[
[
770,
24,
1128
]
],
[
[
770,
21,
28748
],
[
28748,
60,
1128
]
],
[
[
770,
24,
537
],
[
537,
63,
1128
]
],
[
[
770,
24,
1376
],
[
1376,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flavoxate"
]
],
[
[
"Thalidomide",
"{u} (Compound) causes {v} (Side Effect)",
"Vertigo"
],
[
"Vertigo",
"{u} (Side Effect) is caused ... | Thalidomide (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Flavoxate (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Flavoxate
Th... |
DB00188 | DB08912 | 168 | 1,040 | [
"DDInter222",
"DDInter462"
] | Bortezomib | Dabrafenib | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Minor | 0 | [
[
[
168,
23,
1040
]
],
[
[
168,
6,
3486
],
[
3486,
45,
1040
]
],
[
[
168,
7,
2969
],
[
2969,
46,
1040
]
],
[
[
168,
18,
4628
],
[
4628,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dabrafenib"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Bortezomib (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dabrafenib (Compound)
Bortezomib (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Dabrafenib (Compound)
Bortezomib (Compound) downregulates NIPSNAP1 (Gene) and NIPSNAP1 (Gene) is upregulated by Dabrafenib (Compound)
Bortezom... |
DB06589 | DB09104 | 1,250 | 286 | [
"DDInter1400",
"DDInter1118"
] | Pazopanib | Magnesium hydroxide | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1250,
24,
286
]
],
[
[
1250,
63,
820
],
[
820,
23,
286
]
],
[
[
1250,
64,
752
],
[
752,
23,
286
]
],
[
[
1250,
24,
263
],
[
263,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Pazopanib may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine may... |
DB05294 | DB12010 | 1,069 | 214 | [
"DDInter1917",
"DDInter785"
] | Vandetanib | Fostamatinib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1069,
24,
214
]
],
[
[
1069,
63,
690
],
[
690,
24,
214
]
],
[
[
1069,
24,
861
],
[
861,
63,
214
]
],
[
[
1069,
64,
51
],
[
51,
2... | [
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib and Ripret... |
DB01169 | DB14568 | 57 | 982 | [
"DDInter120",
"DDInter1000"
] | Arsenic trioxide | Ivosidenib | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
57,
25,
982
]
],
[
[
57,
62,
112
],
[
112,
23,
982
]
],
[
[
57,
63,
543
],
[
543,
24,
982
]
],
[
[
57,
24,
28
],
[
28,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Loperam... |
DB01409 | DB13913 | 1,415 | 1,536 | [
"DDInter1815",
"DDInter175"
] | Tiotropium | Belladonna | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
1415,
24,
1536
]
],
[
[
1415,
24,
849
],
[
849,
24,
1536
]
],
[
[
1415,
63,
128
],
[
128,
24,
1536
]
],
[
[
1415,
35,
1429
],
[
1429,
... | [
[
[
"Tiotropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Tiotropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine an... |
DB00734 | DB09020 | 1,664 | 28 | [
"DDInter1605",
"DDInter212"
] | Risperidone | Bisacodyl | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1664,
24,
28
]
],
[
[
1664,
24,
662
],
[
662,
1,
28
]
],
[
[
1664,
63,
128
],
[
128,
40,
28
]
],
[
[
1664,
24,
272
],
[
272,
40,... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles... |
DB00687 | DB01136 | 870 | 772 | [
"DDInter747",
"DDInter305"
] | Fludrocortisone | Carvedilol | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
870,
24,
772
]
],
[
[
870,
21,
28876
],
[
28876,
60,
772
]
],
[
[
870,
23,
1283
],
[
1283,
62,
772
]
],
[
[
870,
24,
286
],
[
286,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactoid reaction"
],
[
"Anaphylactoid reactio... | Fludrocortisone (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Carvedilol (Compound)
Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide and Magnesium oxide may cause a minor interaction that can limi... |
DB00408 | DB00748 | 1,408 | 662 | [
"DDInter1099",
"DDInter297"
] | Loxapine | Carbinoxamine | An antipsychotic agent used in schizophrenia. [PubChem] | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
1408,
24,
662
]
],
[
[
1408,
63,
1594
],
[
1594,
24,
662
]
],
[
[
1408,
40,
465
],
[
465,
40,
662
]
],
[
[
1408,
6,
10104
],
[
10104,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Loxapine (Compound) resembles Chlorcyclizine (Compound) and Chlorcyclizine (Compound) resembles Carbinoxamine (... |
DB00277 | DB00585 | 1,031 | 1,127 | [
"DDInter1791",
"DDInter1309"
] | Theophylline | Nizatidine | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Moderate | 1 | [
[
[
1031,
24,
1127
]
],
[
[
1031,
24,
1194
],
[
1194,
40,
1127
]
],
[
[
1031,
21,
28810
],
[
28810,
60,
1127
]
],
[
[
1031,
25,
1467
],
[
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nizatidine"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine (Compound) resembles Nizatidine (Compound)
Theophylline (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Nizatidine (Compound)
Theophylline may... |
DB00748 | DB01173 | 662 | 358 | [
"DDInter297",
"DDInter1349"
] | Carbinoxamine | Orphenadrine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Moderate | 1 | [
[
[
662,
35,
358
]
],
[
[
662,
24,
211
],
[
211,
1,
358
]
],
[
[
662,
1,
11268
],
[
11268,
1,
358
]
],
[
[
662,
35,
272
],
[
272,
24... | [
[
[
"Carbinoxamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Carbinoxamine (Compound) resembles Orphenadrine (Compound) and
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Orphenadrine (Compound)
Carbinoxamine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) res... |
DB00284 | DB00390 | 1,647 | 1,252 | [
"DDInter11",
"DDInter554"
] | Acarbose | Digoxin | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Moderate | 1 | [
[
[
1647,
24,
1252
]
],
[
[
1647,
24,
1482
],
[
1482,
40,
1252
]
],
[
[
1647,
21,
28784
],
[
28784,
60,
1252
]
],
[
[
1647,
1,
416
],
[
41... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
],
[
"Dig... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin (Compound) resembles Digoxin (Compound)
Acarbose (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Digoxin (Compound)
Acarbose (Compound) resembles Kanamycin (C... |
DB00366 | DB12161 | 1,594 | 730 | [
"DDInter600",
"DDInter512"
] | Doxylamine | Deutetrabenazine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
1594,
24,
730
]
],
[
[
1594,
24,
100
],
[
100,
24,
730
]
],
[
[
1594,
35,
128
],
[
128,
24,
730
]
],
[
[
1594,
63,
1242
],
[
1242,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Doxylamine (Compound) resembles Dexbrompheniramine (Compound) and Doxylamine may cause a moderat... |
DB00078 | DB06802 | 1,172 | 282 | [
"DDInter898",
"DDInter1280"
] | Ibritumomab tiuxetan | Nepafenac (ophthalmic) | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Nepafenac is a monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery. It has a role as a prodrug, a cyclooxygenase 2 inhibitor, a cycloox... | Moderate | 1 | [
[
[
1172,
24,
282
]
],
[
[
1172,
37,
886
],
[
886,
1,
282
]
],
[
[
1172,
25,
1512
],
[
1512,
1,
282
]
],
[
[
1172,
25,
1468
],
[
1468,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nepafenac"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead ... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Nepafenac
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Ketorola... |
DB00916 | DB06788 | 112 | 1,616 | [
"DDInter1202",
"DDInter864"
] | Metronidazole | Histrelin | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Minor | 0 | [
[
[
112,
23,
1616
]
],
[
[
112,
23,
1247
],
[
1247,
23,
1616
]
],
[
[
112,
62,
1664
],
[
1664,
24,
1616
]
],
[
[
112,
23,
623
],
[
623,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Histrelin"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Risperidon... |
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