drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00026 | DB12001 | 1,184 | 564 | [
"DDInter94",
"DDInter7"
] | Anakinra | Abemaciclib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
1184,
24,
564
]
],
[
[
1184,
24,
748
],
[
748,
24,
564
]
],
[
[
1184,
24,
151
],
[
151,
63,
564
]
],
[
[
1184,
25,
1011
],
[
1011,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Influenza A vi... |
DB00283 | DB00593 | 701 | 1,464 | [
"DDInter395",
"DDInter695"
] | Clemastine | Ethosuximide | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Moderate | 1 | [
[
[
701,
24,
1464
]
],
[
[
701,
6,
8374
],
[
8374,
45,
1464
]
],
[
[
701,
21,
28691
],
[
28691,
60,
1464
]
],
[
[
701,
24,
401
],
[
401,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethosuximide"
]
],
[
[
"Clemastine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Clemastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethosuximide (Compound)
Clemastine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Ethosuximide (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine ... |
DB00063 | DB06700 | 366 | 643 | [
"DDInter659",
"DDInter511"
] | Eptifibatide | Desvenlafaxine | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
366,
24,
643
]
],
[
[
366,
24,
1100
],
[
1100,
1,
643
]
],
[
[
366,
25,
292
],
[
292,
63,
643
]
],
[
[
366,
24,
1274
],
[
1274,
... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],... | Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Eptifibatide may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may cause a moderate interaction that could ex... |
DB01082 | DB01607 | 1,448 | 1,390 | [
"DDInter1713",
"DDInter1803"
] | Streptomycin | Ticarcillin | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | An antibiotic derived from penicillin similar to carbenicillin in action. | Moderate | 1 | [
[
[
1448,
24,
1390
]
],
[
[
1448,
63,
790
],
[
790,
40,
1390
]
],
[
[
1448,
21,
28680
],
[
28680,
60,
1390
]
],
[
[
1448,
35,
416
],
[
416... | [
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticarcillin"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piperacillin"
],
... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Piperacillin and Piperacillin (Compound) resembles Ticarcillin (Compound)
Streptomycin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Ticarcillin (Compound)
Streptomycin (Compound) resembles Kanamycin ... |
DB00647 | DB01105 | 675 | 222 | [
"DDInter528",
"DDInter1665"
] | Dextropropoxyphene | Sibutramine | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Major | 2 | [
[
[
675,
25,
222
]
],
[
[
675,
6,
8374
],
[
8374,
45,
222
]
],
[
[
675,
18,
4930
],
[
4930,
57,
222
]
],
[
[
675,
21,
28698
],
[
28698,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Dextropropoxyphene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Dextropropoxyphene (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sibutramine (Compound)
Dextropropoxyphene (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibu... |
DB00454 | DB00748 | 1,349 | 662 | [
"DDInter1150",
"DDInter297"
] | Meperidine | Carbinoxamine | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
1349,
24,
662
]
],
[
[
1349,
63,
1594
],
[
1594,
24,
662
]
],
[
[
1349,
6,
8374
],
[
8374,
45,
662
]
],
[
[
1349,
21,
28921
],
[
28921... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[... | Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Meperidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Carbinoxamine (Compound)
Meperidine (... |
DB00262 | DB01041 | 552 | 770 | [
"DDInter302",
"DDInter1789"
] | Carmustine | Thalidomide | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
552,
25,
770
]
],
[
[
552,
5,
11555
],
[
11555,
44,
770
]
],
[
[
552,
6,
7950
],
[
7950,
45,
770
]
],
[
[
552,
21,
28784
],
[
28784,
... | [
[
[
"Carmustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Carmustine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated ... | Carmustine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compound)
Carmustine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Thalidomide (Compound)
Carmustine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is... |
DB08899 | DB11581 | 129 | 1,456 | [
"DDInter649",
"DDInter1926"
] | Enzalutamide | Venetoclax | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
129,
25,
1456
]
],
[
[
129,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
129,
63,
536
],
[
536,
24,
1456
]
],
[
[
129,
25,
241
],
[
241,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u}... | Enzalutamide may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may ca... |
DB00681 | DB00741 | 1,287 | 167 | [
"DDInter85",
"DDInter885"
] | Amphotericin B | Hydrocortisone | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
1287,
24,
167
]
],
[
[
1287,
24,
1220
],
[
1220,
40,
167
]
],
[
[
1287,
63,
175
],
[
175,
40,
167
]
],
[
[
1287,
24,
870
],
[
870,
... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resemble... |
DB00470 | DB00850 | 530 | 1,630 | [
"DDInter601",
"DDInter1432"
] | Dronabinol | Perphenazine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
530,
24,
1630
]
],
[
[
530,
24,
252
],
[
252,
40,
1630
]
],
[
[
530,
63,
508
],
[
508,
40,
1630
]
],
[
[
530,
63,
1242
],
[
1242,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Perphenazine (Compou... |
DB00220 | DB00348 | 798 | 254 | [
"DDInter1276",
"DDInter1300"
] | Nelfinavir | Nitisinone | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Moderate | 1 | [
[
[
798,
24,
254
]
],
[
[
798,
21,
29276
],
[
29276,
60,
254
]
],
[
[
798,
24,
1144
],
[
1144,
63,
254
]
],
[
[
798,
25,
392
],
[
392,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitisinone"
]
],
[
[
"Nelfinavir",
"{u} (Compound) causes {v} (Side Effect)",
"Haemoglobin"
],
[
"Haemoglobin",
"{u} (Side Effect) is ... | Nelfinavir (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Nitisinone (Compound)
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with N... |
DB00934 | DB01166 | 413 | 477 | [
"DDInter1124",
"DDInter379"
] | Maprotiline | Cilostazol | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
413,
24,
477
]
],
[
[
413,
6,
12523
],
[
12523,
45,
477
]
],
[
[
413,
18,
6164
],
[
6164,
57,
477
]
],
[
[
413,
21,
29340
],
[
29340,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Maprotiline",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Maprotiline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cilostazol (Compound)
Maprotiline (Compound) downregulates UFM1 (Gene) and UFM1 (Gene) is downregulated by Cilostazol (Compound)
Maprotiline (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is cau... |
DB00370 | DB01176 | 1,251 | 537 | [
"DDInter1230",
"DDInter453"
] | Mirtazapine | Cyclizine | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1251,
24,
537
]
],
[
[
1251,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1251,
1,
104
],
[
104,
1,
537
]
],
[
[
1251,
1,
11321
],
[
11321,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Mirtazapine (Compound) resembles Methdilazine (Compound) and Methdilazine (Compound) resembles Cyclizine (Compou... |
DB01073 | DB13007 | 1,488 | 1,060 | [
"DDInter745",
"DDInter642"
] | Fludarabine | Enfortumab vedotin | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
1488,
24,
1060
]
],
[
[
1488,
24,
1593
],
[
1593,
24,
1060
]
],
[
[
1488,
63,
58
],
[
58,
24,
1060
]
],
[
[
1488,
64,
770
],
[
770,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept a... |
DB00331 | DB11921 | 1,645 | 1,019 | [
"DDInter1164",
"DDInter492"
] | Metformin | Deflazacort | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1645,
24,
1019
]
],
[
[
1645,
24,
1072
],
[
1072,
23,
1019
]
],
[
[
1645,
24,
192
],
[
192,
24,
1019
]
],
[
[
1645,
24,
1619
],
[
1619... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens and E... |
DB01172 | DB01327 | 416 | 1,227 | [
"DDInter1004",
"DDInter314"
] | Kanamycin | Cefazolin | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. | Moderate | 1 | [
[
[
416,
24,
1227
]
],
[
[
416,
24,
1124
],
[
1124,
40,
1227
]
],
[
[
416,
63,
665
],
[
665,
40,
1227
]
],
[
[
416,
63,
277
],
[
277,
... | [
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefazolin"
]
],
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefamandole"
],
[
... | Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Cefamandole and Cefamandole (Compound) resembles Cefazolin (Compound)
Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Cefazolin (Compound)
Ka... |
DB01168 | DB04861 | 1,053 | 1,592 | [
"DDInter1526",
"DDInter1271"
] | Procarbazine | Nebivolol | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1053,
24,
1592
]
],
[
[
1053,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
1053,
24,
144
],
[
144,
63,
1592
]
],
[
[
1053,
64,
1445
],
[
14... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Procarbazine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cau... | Procarbazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Nebivo... |
DB00197 | DB00539 | 1,324 | 11 | [
"DDInter1881",
"DDInter1837"
] | Troglitazone | Toremifene | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Moderate | 1 | [
[
[
1324,
24,
11
]
],
[
[
1324,
24,
939
],
[
939,
40,
11
]
],
[
[
1324,
24,
723
],
[
723,
63,
11
]
],
[
[
1324,
24,
811
],
[
811,
24... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Toremifene (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction ... |
DB01073 | DB01097 | 1,488 | 1,377 | [
"DDInter745",
"DDInter1033"
] | Fludarabine | Leflunomide | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1488,
25,
1377
]
],
[
[
1488,
21,
29062
],
[
29062,
60,
1377
]
],
[
[
1488,
63,
1461
],
[
1461,
23,
1377
]
],
[
[
1488,
24,
949
],
[
9... | [
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Fludarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Neutropenia"
],
[
"Neutropenia",
"{u} (Side Effect) is caused by {v... | Fludarabine (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound)
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Lefl... |
DB00641 | DB12267 | 467 | 1,476 | [
"DDInter1675",
"DDInter233"
] | Simvastatin | Brigatinib | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
467,
24,
1476
]
],
[
[
467,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
467,
25,
1206
],
[
1206,
23,
1476
]
],
[
[
467,
63,
168
],
[
168,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Simvastatin may lead to a major life threatening interaction when taken with Gemfibrozil and Gemfibrozil may ca... |
DB00559 | DB00619 | 152 | 1,419 | [
"DDInter223",
"DDInter909"
] | Bosentan | Imatinib | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
152,
24,
1419
]
],
[
[
152,
6,
6017
],
[
6017,
45,
1419
]
],
[
[
152,
21,
28847
],
[
28847,
60,
1419
]
],
[
[
152,
24,
222
],
[
222,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Bosentan",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Bosentan (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Imatinib (Compound)
Bosentan (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Imatinib (Compound)
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutra... |
DB01138 | DB12001 | 804 | 564 | [
"DDInter1726",
"DDInter7"
] | Sulfinpyrazone | Abemaciclib | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
804,
24,
564
]
],
[
[
804,
24,
868
],
[
868,
24,
564
]
],
[
[
804,
25,
1213
],
[
1213,
24,
564
]
],
[
[
804,
63,
723
],
[
723,
2... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Sulfinpyrazone may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib m... |
DB01168 | DB06688 | 1,053 | 1,430 | [
"DDInter1526",
"DDInter1677"
] | Procarbazine | Sipuleucel-T | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
1053,
24,
1430
]
],
[
[
1053,
63,
869
],
[
869,
24,
1430
]
],
[
[
1053,
25,
676
],
[
676,
63,
1430
]
],
[
[
1053,
24,
1531
],
[
1531,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
],
... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Procarbazine may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib ma... |
DB00056 | DB09074 | 816 | 1,362 | [
"DDInter814",
"DDInter1327"
] | Gemtuzumab ozogamicin | Olaparib | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
816,
24,
1362
]
],
[
[
816,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
816,
24,
987
],
[
987,
63,
1362
]
],
[
[
816,
25,
990
],
[
990,
... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekin... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00222 | DB00224 | 245 | 215 | [
"DDInter825",
"DDInter917"
] | Glimepiride | Indinavir | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Moderate | 1 | [
[
[
245,
24,
215
]
],
[
[
245,
63,
798
],
[
798,
1,
215
]
],
[
[
245,
24,
1327
],
[
1327,
1,
215
]
],
[
[
245,
6,
6017
],
[
6017,
45... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indinavir"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Indinavir (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Indinavir (Compound)
... |
DB00574 | DB00749 | 121 | 59 | [
"DDInter717",
"DDInter699"
] | Fenfluramine | Etodolac | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
121,
24,
59
]
],
[
[
121,
63,
25
],
[
25,
24,
59
]
],
[
[
121,
24,
1383
],
[
1383,
63,
59
]
],
[
[
121,
25,
1039
],
[
1039,
63,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anistreplase"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate ... |
DB00086 | DB00208 | 1,167 | 1,018 | [
"DDInter1712",
"DDInter1804"
] | Streptokinase | Ticlopidine | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Moderate | 1 | [
[
[
1167,
24,
1018
]
],
[
[
1167,
24,
1347
],
[
1347,
64,
1018
]
],
[
[
1167,
23,
1631
],
[
1631,
62,
1018
]
],
[
[
1167,
24,
643
],
[
643... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
],
... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may lead to a major life threatening interaction when taken with Ticlopidine
Streptokinase may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cau... |
DB00418 | DB01246 | 536 | 820 | [
"DDInter1650",
"DDInter45"
] | Secobarbital | Alimemazine | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
536,
24,
820
]
],
[
[
536,
24,
104
],
[
104,
40,
820
]
],
[
[
536,
24,
401
],
[
401,
24,
820
]
],
[
[
536,
24,
649
],
[
649,
1,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interacti... |
DB00486 | DB00902 | 1,614 | 104 | [
"DDInter1253",
"DDInter1168"
] | Nabilone | Methdilazine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1614,
24,
104
]
],
[
[
1614,
63,
13
],
[
13,
24,
104
]
],
[
[
1614,
24,
820
],
[
820,
1,
104
]
],
[
[
1614,
24,
537
],
[
537,
40... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and... |
DB00222 | DB15093 | 245 | 1,654 | [
"DDInter825",
"DDInter1698"
] | Glimepiride | Somapacitan | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
245,
24,
1654
]
],
[
[
245,
63,
168
],
[
168,
23,
1654
]
],
[
[
245,
24,
433
],
[
433,
24,
1654
]
],
[
[
245,
63,
176
],
[
176,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin and Er... |
DB00191 | DB01367 | 73 | 1,163 | [
"DDInter1447",
"DDInter1572"
] | Phentermine | Rasagiline | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
73,
24,
1163
]
],
[
[
73,
6,
7950
],
[
7950,
45,
1163
]
],
[
[
73,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
73,
24,
590
],
[
590,
... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Phentermine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Phentermine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rasagiline (Compound)
Phentermine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and ... |
DB01097 | DB04845 | 1,377 | 309 | [
"DDInter1033",
"DDInter1001"
] | Leflunomide | Ixabepilone | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Major | 2 | [
[
[
1377,
25,
309
]
],
[
[
1377,
21,
28987
],
[
28987,
60,
309
]
],
[
[
1377,
25,
60
],
[
60,
23,
309
]
],
[
[
1377,
64,
1419
],
[
1419,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixabepilone"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Chills"
],
[
"Chills",
"{u} (Side Effect) is caused by {v} (Compoun... | Leflunomide (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Ixabepilone
Leflunomide... |
DB00400 | DB09570 | 353 | 1,480 | [
"DDInter843",
"DDInter1002"
] | Griseofulvin | Ixazomib | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
353,
24,
1480
]
],
[
[
353,
24,
1598
],
[
1598,
63,
1480
]
],
[
[
353,
24,
310
],
[
310,
24,
1480
]
],
[
[
353,
63,
1023
],
[
1023,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat and Tazemetostat may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and... |
DB00668 | DB13139 | 874 | 1,032 | [
"DDInter652",
"DDInter1063"
] | Epinephrine | Levosalbutamol | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
874,
24,
1032
]
],
[
[
874,
63,
73
],
[
73,
24,
1032
]
],
[
[
874,
24,
659
],
[
659,
24,
1032
]
],
[
[
874,
40,
1636
],
[
1636,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol an... |
DB00928 | DB09054 | 1,426 | 384 | [
"DDInter148",
"DDInter905"
] | Azacitidine | Idelalisib | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1426,
24,
384
]
],
[
[
1426,
63,
58
],
[
58,
24,
384
]
],
[
[
1426,
24,
287
],
[
287,
63,
384
]
],
[
[
1426,
1,
1238
],
[
1238,
... | [
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate an... |
DB00218 | DB06603 | 1,176 | 39 | [
"DDInter1247",
"DDInter1387"
] | Moxifloxacin | Panobinostat | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1176,
25,
39
]
],
[
[
1176,
23,
112
],
[
112,
23,
39
]
],
[
[
1176,
63,
912
],
[
912,
24,
39
]
],
[
[
1176,
24,
455
],
[
455,
24... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Interferon be... |
DB00938 | DB01324 | 455 | 178 | [
"DDInter1635",
"DDInter1490"
] | Salmeterol | Polythiazide | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
455,
24,
178
]
],
[
[
455,
24,
674
],
[
674,
40,
178
]
],
[
[
455,
63,
359
],
[
359,
40,
178
]
],
[
[
455,
21,
28835
],
[
28835,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resemb... |
DB00987 | DB14550 | 1,224 | 821 | [
"DDInter460",
"DDInter803"
] | Cytarabine | Gallium chloride Ga-67 | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Gallium chloride Ga-67 is the chloride salt of a gallium radioisotope which is typically complexed with [sodium citrate] to generate [gallium citrate Ga 67], which can be used to image certain cancers and inflammatory lesions. | Moderate | 1 | [
[
[
1224,
24,
821
]
],
[
[
1224,
63,
663
],
[
663,
24,
821
]
],
[
[
1224,
63,
663
],
[
663,
24,
1220
],
[
1220,
24,
821
]
],
[
[
1224,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gallium chloride Ga-67"
]
],
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Gallium chloride Ga-67
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Metho... |
DB00494 | DB14491 | 1,533 | 428 | [
"DDInter646",
"DDInter725"
] | Entacapone | Ferrous fumarate | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
1533,
24,
428
]
],
[
[
1533,
6,
17106
],
[
17106,
45,
1096
],
[
1096,
23,
428
]
],
[
[
1533,
18,
14549
],
[
14549,
46,
1096
],
[
1096,
... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Entacapone",
"{u} (Compound) binds {v} (Gene)",
"UGT1A9"
],
[
"UGT1A9",
"{u} (Gene) is bound by {v} (Compo... | Entacapone (Compound) binds UGT1A9 (Gene) and UGT1A9 (Gene) is bound by Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Entacapone (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is upregulated by Mycophenolic aci... |
DB01403 | DB06176 | 9 | 1,342 | [
"DDInter1175",
"DDInter1616"
] | Methotrimeprazine | Romidepsin | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
9,
24,
1342
]
],
[
[
9,
62,
112
],
[
112,
23,
1342
]
],
[
[
9,
63,
485
],
[
485,
24,
1342
]
],
[
[
9,
24,
1616
],
[
1616,
63,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Methotrimeprazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Penta... |
DB00712 | DB05578 | 1,274 | 330 | [
"DDInter764",
"DDInter1566"
] | Flurbiprofen (ophthalmic) | Ramucirumab | Flurbiprofen can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements. | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Moderate | 1 | [
[
[
1274,
37,
330
]
],
[
[
1274,
24,
41
],
[
41,
63,
330
]
],
[
[
1274,
24,
901
],
[
901,
24,
330
]
],
[
[
1274,
63,
1100
],
[
1100,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that ... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab and Flurbiprofen may lead to a major life threatening interaction when taken with Ramucirumab
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomiln... |
DB01044 | DB09322 | 246 | 1,114 | [
"DDInter809",
"DDInter1966"
] | Gatifloxacin | Zinc sulfate | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Moderate | 1 | [
[
[
246,
24,
1114
]
],
[
[
246,
64,
251
],
[
251,
23,
1114
]
],
[
[
246,
62,
1307
],
[
1307,
23,
1114
]
],
[
[
246,
25,
1220
],
[
1220,
... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betamethasone"
],
[
"B... | Gatifloxacin may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Melphalan and Melphalan may ... |
DB00477 | DB00486 | 216 | 1,614 | [
"DDInter363",
"DDInter1253"
] | Chlorpromazine | Nabilone | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
216,
24,
1614
]
],
[
[
216,
63,
530
],
[
530,
1,
1614
]
],
[
[
216,
21,
28789
],
[
28789,
60,
1614
]
],
[
[
216,
63,
999
],
[
999,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Chlorpromazine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Nabilone (Compound)
Chlorpromazine m... |
DB00046 | DB01165 | 1,179 | 1,539 | [
"DDInter940",
"DDInter1325"
] | Insulin lispro | Ofloxacin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Major | 2 | [
[
[
1179,
25,
1539
]
],
[
[
1179,
25,
1467
],
[
1467,
1,
1539
]
],
[
[
1179,
25,
945
],
[
945,
40,
1539
]
],
[
[
1179,
24,
1021
],
[
1021,... | [
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofloxacin"
]
],
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxacin"
],
[
"Enoxacin",
"{u... | Insulin lispro may lead to a major life threatening interaction when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Insulin lispro may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Insulin lispro may cause... |
DB00465 | DB01249 | 886 | 258 | [
"DDInter1010",
"DDInter958"
] | Ketorolac | Iodixanol | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
886,
25,
258
]
],
[
[
886,
25,
497
],
[
497,
1,
258
]
],
[
[
886,
21,
28748
],
[
28748,
60,
258
]
],
[
[
886,
24,
712
],
[
712,
... | [
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u} (Compound)... | Ketorolac may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Ketorolac (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Ketorolac may cause a moderate interaction that could exacerbate diseases... |
DB00040 | DB01359 | 27 | 729 | [
"DDInter827",
"DDInter1417"
] | Glucagon | Penbutolol | Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and... | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Minor | 0 | [
[
[
27,
23,
729
]
],
[
[
27,
23,
461
],
[
461,
1,
729
]
],
[
[
27,
23,
493
],
[
493,
40,
729
]
],
[
[
27,
23,
126
],
[
126,
23,
... | [
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Penbutolol"
]
],
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Timolol"
],
[
"Timolo... | Glucagon may cause a minor interaction that can limit clinical effects when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Glucagon may cause a minor interaction that can limit clinical effects when taken with Carteolol and Carteolol (Compound) resembles Penbutolol (Compound)
Glucagon may cau... |
DB00477 | DB00857 | 216 | 1,387 | [
"DDInter363",
"DDInter1768"
] | Chlorpromazine | Terbinafine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
216,
24,
1387
]
],
[
[
216,
6,
8374
],
[
8374,
45,
1387
]
],
[
[
216,
7,
6134
],
[
6134,
45,
1387
]
],
[
[
216,
7,
4634
],
[
4634,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Chlorpromazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Chlorpromazine (Compound) upregulates SQLE (Gene) and SQLE (Gene) is bound by Terbinafine (Compound)
Chlorpromazine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Terbinafine (Compound)
Chlorpromaz... |
DB00191 | DB00601 | 73 | 453 | [
"DDInter1447",
"DDInter1073"
] | Phentermine | Linezolid | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Major | 2 | [
[
[
73,
25,
453
]
],
[
[
73,
6,
8774
],
[
8774,
45,
453
]
],
[
[
73,
21,
28757
],
[
28757,
60,
453
]
],
[
[
73,
24,
659
],
[
659,
63... | [
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Linezolid"
]
],
[
[
"Phentermine",
"{u} (Compound) binds {v} (Gene)",
"MAOB"
],
[
"MAOB",
"{u} (Gene) is bound by {v} (Compound)",
"Linezolid"... | Phentermine (Compound) binds MAOB (Gene) and MAOB (Gene) is bound by Linezolid (Compound)
Phentermine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Linezolid (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilante... |
DB00069 | DB00916 | 367 | 112 | [
"DDInter946",
"DDInter1202"
] | Interferon alfacon-1 | Metronidazole | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
367,
24,
112
]
],
[
[
367,
24,
458
],
[
458,
40,
112
]
],
[
[
367,
24,
996
],
[
996,
62,
112
]
],
[
[
367,
25,
695
],
[
695,
23,... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tini... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) resembles Metronidazole (Compound)
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a minor ... |
DB00563 | DB11256 | 663 | 95 | [
"DDInter1174",
"DDInter1057"
] | Methotrexate | Levomefolic acid | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma . It is transported across the membranes including the blood-brain barrier into various tissues where it plays an e... | Moderate | 1 | [
[
[
663,
24,
95
]
],
[
[
663,
24,
50
],
[
50,
23,
95
]
],
[
[
663,
63,
970
],
[
970,
25,
95
]
],
[
[
663,
24,
712
],
[
712,
1,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomefolic acid"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may cause a minor interaction that can limit clinical effects when taken with Levomefolic acid
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Fluorou... |
DB00861 | DB01309 | 914 | 1,254 | [
"DDInter551",
"DDInter933"
] | Diflunisal | Insulin glulisine | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
914,
24,
1254
]
],
[
[
914,
24,
554
],
[
554,
62,
1254
]
],
[
[
914,
63,
1621
],
[
1621,
23,
1254
]
],
[
[
914,
63,
167
],
[
167,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium perchlorat... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate and Potassium perchlorate may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken... |
DB00690 | DB09054 | 1,216 | 384 | [
"DDInter762",
"DDInter905"
] | Flurazepam | Idelalisib | A benzodiazepine derivative used mainly as a hypnotic. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1216,
24,
384
]
],
[
[
1216,
24,
222
],
[
222,
23,
384
]
],
[
[
1216,
40,
1565
],
[
1565,
24,
384
]
],
[
[
1216,
63,
1648
],
[
1648,
... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Flurazepam (Compound) resembles Clonazepam (Compound) and Clonazepam may cause a moderate interaction that could... |
DB09100 | DB13928 | 320 | 1,385 | [
"DDInter1799",
"DDInter1660"
] | Thyroid, porcine | Semaglutide | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
320,
24,
1385
]
],
[
[
320,
63,
1445
],
[
1445,
24,
1385
]
],
[
[
320,
24,
1296
],
[
1296,
24,
1385
]
],
[
[
320,
62,
417
],
[
417,
... | [
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrin... | Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01132 | DB06636 | 1,130 | 1,623 | [
"DDInter1472",
"DDInter980"
] | Pioglitazone | Isavuconazonium | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1130,
24,
1623
]
],
[
[
1130,
63,
222
],
[
222,
23,
1623
]
],
[
[
1130,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
1130,
24,
1250
],
[
1250... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Isavuconazonium
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and... |
DB00734 | DB01124 | 1,664 | 1,411 | [
"DDInter1605",
"DDInter1828"
] | Risperidone | Tolbutamide | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1664,
24,
1411
]
],
[
[
1664,
24,
959
],
[
959,
40,
1411
]
],
[
[
1664,
63,
245
],
[
245,
40,
1411
]
],
[
[
1664,
21,
28746
],
[
28746... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compou... |
DB00106 | DB01118 | 618 | 33 | [
"DDInter4",
"DDInter76"
] | Abarelix | Amiodarone | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Major | 2 | [
[
[
618,
25,
33
]
],
[
[
618,
25,
540
],
[
540,
1,
33
]
],
[
[
618,
24,
455
],
[
455,
24,
33
]
],
[
[
618,
24,
286
],
[
286,
63,
... | [
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
],
[
"Dronedarone",
"{u} (Co... | Abarelix may lead to a major life threatening interaction when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate disea... |
DB00395 | DB01501 | 210 | 1,118 | [
"DDInter301",
"DDInter549"
] | Carisoprodol | Difenoxin | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with b... | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Moderate | 1 | [
[
[
210,
24,
1118
]
],
[
[
210,
24,
1688
],
[
1688,
40,
1118
]
],
[
[
210,
24,
506
],
[
506,
24,
1118
]
],
[
[
210,
24,
1609
],
[
1609,
... | [
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difenoxin"
]
],
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenoxylate"
],
... | Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Difenoxin (Compound)
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate i... |
DB01619 | DB11601 | 830 | 1,270 | [
"DDInter1441",
"DDInter1889"
] | Phenindamine | Tuberculin purified protein derivative | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
830,
24,
1270
]
],
[
[
830,
63,
13
],
[
13,
24,
1270
]
],
[
[
830,
24,
516
],
[
516,
24,
1270
]
],
[
[
830,
1,
1219
],
[
1219,
2... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Phenindamine may cause a moderate interaction that could exacerbate diseas... |
DB00526 | DB01128 | 1,555 | 918 | [
"DDInter1355",
"DDInter204"
] | Oxaliplatin | Bicalutamide | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
1555,
24,
918
]
],
[
[
1555,
24,
129
],
[
129,
40,
918
]
],
[
[
1555,
24,
112
],
[
112,
23,
918
]
],
[
[
1555,
23,
1247
],
[
1247,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction... |
DB01081 | DB01452 | 1,688 | 993 | [
"DDInter571",
"DDInter532"
] | Diphenoxylate | Diamorphine | A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Subst... | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Moderate | 1 | [
[
[
1688,
24,
993
]
],
[
[
1688,
6,
6591
],
[
6591,
45,
993
]
],
[
[
1688,
40,
1118
],
[
1118,
63,
993
]
],
[
[
1688,
63,
1594
],
[
1594,
... | [
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diamorphine"
]
],
[
[
"Diphenoxylate",
"{u} (Compound) binds {v} (Gene)",
"OPRM1"
],
[
"OPRM1",
"{u} (Gene) is bound by {v} (Compou... | Diphenoxylate (Compound) binds OPRM1 (Gene) and OPRM1 (Gene) is bound by Diamorphine (Compound)
Diphenoxylate (Compound) resembles Difenoxin (Compound) and Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Diamorphine
Diphenoxylate may cause a moderate interaction that could exac... |
DB01177 | DB06589 | 77 | 1,250 | [
"DDInter904",
"DDInter1400"
] | Idarubicin | Pazopanib | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
77,
24,
1250
]
],
[
[
77,
7,
2653
],
[
2653,
45,
1250
]
],
[
[
77,
6,
12523
],
[
12523,
45,
1250
]
],
[
[
77,
18,
9202
],
[
9202,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Idarubicin",
"{u} (Compound) upregulates {v} (Gene)",
"LIMK2"
],
[
"LIMK2",
"{u} (Gene) is bound by {v} (Compound... | Idarubicin (Compound) upregulates LIMK2 (Gene) and LIMK2 (Gene) is bound by Pazopanib (Compound)
Idarubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pazopanib (Compound)
Idarubicin (Compound) downregulates PLK4 (Gene) and PLK4 (Gene) is bound by Pazopanib (Compound)
Idarubicin (Compound) downregulat... |
DB00106 | DB00734 | 618 | 1,664 | [
"DDInter4",
"DDInter1605"
] | Abarelix | Risperidone | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
618,
24,
1664
]
],
[
[
618,
25,
924
],
[
924,
40,
1664
]
],
[
[
618,
24,
519
],
[
519,
40,
1664
]
],
[
[
618,
23,
112
],
[
112,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
],
[
"Iloperidone"... | Abarelix may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Risperidone (Compound)
Abarelix ma... |
DB00991 | DB01082 | 97 | 1,448 | [
"DDInter1358",
"DDInter1713"
] | Oxaprozin | Streptomycin | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
97,
24,
1448
]
],
[
[
97,
21,
29327
],
[
29327,
60,
1448
]
],
[
[
97,
24,
1272
],
[
1272,
63,
1448
]
],
[
[
97,
40,
998
],
[
998,
... | [
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Oxaprozin",
"{u} (Compound) causes {v} (Side Effect)",
"Renal failure"
],
[
"Renal failure",
"{u} (Side Effect)... | Oxaprozin (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine and Flucytosine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00334 | DB00836 | 867 | 543 | [
"DDInter1326",
"DDInter1088"
] | Olanzapine | Loperamide | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
867,
24,
543
]
],
[
[
867,
24,
649
],
[
649,
1,
543
]
],
[
[
867,
24,
262
],
[
262,
24,
543
]
],
[
[
867,
63,
701
],
[
701,
24,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Loperamide (Compound)
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that could e... |
DB05679 | DB08895 | 1,683 | 976 | [
"DDInter1907",
"DDInter1825"
] | Ustekinumab | Tofacitinib | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1683,
25,
976
]
],
[
[
1683,
23,
1193
],
[
1193,
62,
976
]
],
[
[
1683,
62,
1461
],
[
1461,
23,
976
]
],
[
[
1683,
24,
200
],
[
200,
... | [
[
[
"Ustekinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Ustekinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc ... | Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vi... |
DB01240 | DB09075 | 885 | 498 | [
"DDInter657",
"DDInter621"
] | Epoprostenol | Edoxaban | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
885,
25,
498
]
],
[
[
885,
23,
944
],
[
944,
62,
498
]
],
[
[
885,
24,
1004
],
[
1004,
63,
498
]
],
[
[
885,
24,
41
],
[
41,
24,... | [
[
[
"Epoprostenol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Epoprostenol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",... | Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phe... |
DB00609 | DB00911 | 595 | 458 | [
"DDInter694",
"DDInter1811"
] | Ethionamide | Tinidazole | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
595,
24,
458
]
],
[
[
595,
24,
112
],
[
112,
1,
458
]
],
[
[
595,
21,
28868
],
[
28868,
60,
458
]
],
[
[
595,
24,
310
],
[
310,
... | [
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Ethionamide (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Tinidazole (Compound)
Ethionamide may cause a moderate i... |
DB00065 | DB00951 | 581 | 1,072 | [
"DDInter923",
"DDInter986"
] | Infliximab | Isoniazid | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
581,
24,
1072
]
],
[
[
581,
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],
[
1486,
62,
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]
],
[
[
581,
25,
870
],
[
870,
23,
1072
]
],
[
[
581,
24,
1031
],
[
1031,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
],
[
"Met... | Infliximab may lead to a major life threatening interaction when taken with Methylprednisolone and Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Isoniazid
Infliximab may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone ma... |
DB00569 | DB06081 | 553 | 1,046 | [
"DDInter775",
"DDInter286"
] | Fondaparinux | Caplacizumab | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Major | 2 | [
[
[
553,
25,
1046
]
],
[
[
553,
23,
1631
],
[
1631,
62,
1046
]
],
[
[
553,
24,
1039
],
[
1039,
24,
1046
]
],
[
[
553,
25,
1171
],
[
1171,
... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
]
],
[
[
"Fondaparinux",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric... | Fondaparinux may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Caplacizumab
Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dex... |
DB00405 | DB00726 | 128 | 1,164 | [
"DDInter517",
"DDInter1876"
] | Dexbrompheniramine | Trimipramine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
128,
24,
1164
]
],
[
[
128,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
128,
25,
675
],
[
675,
40,
1164
]
],
[
[
128,
40,
11244
],
[
11244,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipram... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Dexbrompheniramine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles... |
DB00258 | DB01059 | 666 | 956 | [
"DDInter270",
"DDInter1313"
] | Calcium acetate | Norfloxacin | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
666,
24,
956
]
],
[
[
666,
24,
872
],
[
872,
40,
956
]
],
[
[
666,
63,
1176
],
[
1176,
1,
956
]
],
[
[
666,
24,
1539
],
[
1539,
... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Nor... |
DB00842 | DB09154 | 686 | 1,475 | [
"DDInter1359",
"DDInter1686"
] | Oxazepam | Sodium citrate | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Minor | 0 | [
[
[
686,
23,
1475
]
],
[
[
686,
1,
902
],
[
902,
23,
1475
]
],
[
[
686,
40,
523
],
[
523,
23,
1475
]
],
[
[
686,
23,
115
],
[
115,
2... | [
[
[
"Oxazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium citrate"
]
],
[
[
"Oxazepam",
"{u} (Compound) resembles {v} (Compound)",
"Clobazam"
],
[
"Clobazam",
"{u} may cause a minor interac... | Oxazepam (Compound) resembles Clobazam (Compound) and Clobazam may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Oxazepam (Compound) resembles Alprazolam (Compound) and Alprazolam may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Oxaz... |
DB00208 | DB08918 | 1,018 | 41 | [
"DDInter1804",
"DDInter1059"
] | Ticlopidine | Levomilnacipran | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
1018,
24,
41
]
],
[
[
1018,
24,
901
],
[
901,
40,
41
]
],
[
[
1018,
6,
10215
],
[
10215,
45,
41
]
],
[
[
1018,
21,
29209
],
[
29209,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Ticlopidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Levomilnacipran (Compound)
Ticlopidine (Compound) causes Anorexia (Side Effec... |
DB00262 | DB11627 | 552 | 1,367 | [
"DDInter302",
"DDInter860"
] | Carmustine | Hepatitis B Vaccine (Recombinant) | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
552,
24,
1367
]
],
[
[
552,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
552,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
552,
24,
259
],
[
259,
... | [
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alde... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Carmustine may lead to a major life threatening interaction when taken with Cladribine ... |
DB06824 | DB09407 | 29 | 853 | [
"DDInter1864",
"DDInter1114"
] | Triethylenetetramine | Magnesium chloride | Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925. Initially approved... | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Moderate | 1 | [
[
[
29,
24,
853
]
],
[
[
29,
24,
460
],
[
460,
63,
853
]
],
[
[
29,
24,
286
],
[
286,
24,
853
]
],
[
[
29,
63,
1283
],
[
1283,
24,
... | [
[
[
"Triethylenetetramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
]
],
[
[
"Triethylenetetramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Triethylenetetramine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium carbonate and Magnesium carbonate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride
Triethylenetetramine may cause a moderate interaction that could exacerbate ... |
DB00539 | DB11979 | 11 | 1,320 | [
"DDInter1837",
"DDInter625"
] | Toremifene | Elagolix | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
11,
24,
1320
]
],
[
[
11,
25,
1612
],
[
1612,
23,
1320
]
],
[
[
11,
25,
1297
],
[
1297,
24,
1320
]
],
[
[
11,
64,
79
],
[
79,
24... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
],
[
"Fostemsavir... | Toremifene may lead to a major life threatening interaction when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Elagolix
Toremifene may lead to a major life threatening interaction when taken with Osilodrostat and Osilodrostat may cause a moderate in... |
DB01097 | DB06650 | 1,377 | 1,500 | [
"DDInter1033",
"DDInter1324"
] | Leflunomide | Ofatumumab | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Major | 2 | [
[
[
1377,
25,
1500
]
],
[
[
1377,
25,
270
],
[
270,
63,
1500
]
],
[
[
1377,
24,
1129
],
[
1129,
63,
1500
]
],
[
[
1377,
64,
869
],
[
869,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofatumumab"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ocrelizumab"
],
[
"Ocrelizumab",
"{... | Leflunomide may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Ofatumumab
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 st... |
DB00450 | DB09268 | 78 | 1,662 | [
"DDInter603",
"DDInter1464"
] | Droperidol | Picosulfuric acid | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Major | 2 | [
[
[
78,
25,
1662
]
],
[
[
78,
25,
484
],
[
484,
63,
1662
]
],
[
[
78,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
78,
1,
1300
],
[
1300,
2... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
],
[
"Entrectinib",
... | Droperidol may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Droperidol may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a ... |
DB01278 | DB01579 | 1,021 | 341 | [
"DDInter1506",
"DDInter1439"
] | Pramlintide | Phendimetrazine | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Moderate | 1 | [
[
[
1021,
24,
341
]
],
[
[
1021,
63,
959
],
[
959,
24,
341
]
],
[
[
1021,
24,
1254
],
[
1254,
24,
341
]
],
[
[
1021,
24,
1296
],
[
1296,
... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Phendimetrazine
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisin... |
DB04953 | DB05239 | 495 | 866 | [
"DDInter708",
"DDInter425"
] | Ezogabine | Cobimetinib | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
495,
24,
866
]
],
[
[
495,
63,
888
],
[
888,
24,
866
]
],
[
[
495,
24,
484
],
[
484,
63,
866
]
],
[
[
495,
25,
1069
],
[
1069,
6... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[
... | Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrecti... |
DB00705 | DB01222 | 441 | 617 | [
"DDInter496",
"DDInter246"
] | Delavirdine | Budesonide | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Major | 2 | [
[
[
441,
25,
617
]
],
[
[
441,
63,
1351
],
[
1351,
1,
617
]
],
[
[
441,
64,
175
],
[
175,
1,
617
]
],
[
[
441,
24,
1220
],
[
1220,
1... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flunisolide"
],
[
"Fluniso... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Budesonide (Compound)
Delavirdine may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Budesonide (Compound)
Delav... |
DB01263 | DB11967 | 859 | 710 | [
"DDInter1494",
"DDInter210"
] | Posaconazole | Binimetinib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
859,
24,
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]
],
[
[
859,
25,
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],
[
1593,
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]
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[
[
859,
64,
1557
],
[
1557,
24,
710
]
],
[
[
859,
63,
883
],
[
883,
... | [
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizo... | Posaconazole may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Posaconazole may lead to a major life threatening interaction when taken with Astemizole and Astemizole may cause a moderate... |
DB00865 | DB00912 | 939 | 473 | [
"DDInter187",
"DDInter1581"
] | Benzphetamine | Repaglinide | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
939,
24,
473
]
],
[
[
939,
6,
8374
],
[
8374,
45,
473
]
],
[
[
939,
21,
28757
],
[
28757,
60,
473
]
],
[
[
939,
64,
73
],
[
73,
... | [
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Benzphetamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Benzphetamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Repaglinide (Compound)
Benzphetamine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Repaglinide (Compound)
Benzphetamine may lead to a major life threatening interaction when taken with Phentermine and Phenter... |
DB00704 | DB00879 | 267 | 1,279 | [
"DDInter1263",
"DDInter637"
] | Naltrexone | Emtricitabine | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse t... | Moderate | 1 | [
[
[
267,
24,
1279
]
],
[
[
267,
21,
28666
],
[
28666,
60,
1279
]
],
[
[
267,
63,
322
],
[
322,
24,
1279
]
],
[
[
267,
24,
384
],
[
384,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emtricitabine"
]
],
[
[
"Naltrexone",
"{u} (Compound) causes {v} (Side Effect)",
"Nervous system disorder"
],
[
"Nervous system disorder",
... | Naltrexone (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Emtricitabine (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate d... |
DB00365 | DB01124 | 839 | 1,411 | [
"DDInter842",
"DDInter1828"
] | Grepafloxacin | Tolbutamide | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Major | 2 | [
[
[
839,
25,
1411
]
],
[
[
839,
25,
959
],
[
959,
40,
1411
]
],
[
[
839,
64,
245
],
[
245,
40,
1411
]
],
[
[
839,
24,
1475
],
[
1475,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tolbutamide"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glipizide"
],
[
"Glipizide",
"... | Grepafloxacin may lead to a major life threatening interaction when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Grepafloxacin may lead to a major life threatening interaction when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
Grepafloxacin may caus... |
DB00470 | DB00999 | 530 | 504 | [
"DDInter601",
"DDInter883"
] | Dronabinol | Hydrochlorothiazide | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
530,
24,
504
]
],
[
[
530,
24,
178
],
[
178,
1,
504
]
],
[
[
530,
63,
323
],
[
323,
40,
504
]
],
[
[
530,
24,
359
],
[
359,
40,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Hydrochlorothiazide (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide (Compound) r... |
DB00361 | DB11791 | 134 | 785 | [
"DDInter1939",
"DDInter287"
] | Vinorelbine | Capmatinib | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
134,
24,
785
]
],
[
[
134,
24,
310
],
[
310,
24,
785
]
],
[
[
134,
63,
482
],
[
482,
24,
785
]
],
[
[
134,
24,
283
],
[
283,
63,... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Ti... |
DB04868 | DB06402 | 478 | 1,079 | [
"DDInter1293",
"DDInter1756"
] | Nilotinib | Telavancin | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Major | 2 | [
[
[
478,
25,
1079
]
],
[
[
478,
21,
28750
],
[
28750,
60,
1079
]
],
[
[
478,
62,
112
],
[
112,
23,
1079
]
],
[
[
478,
24,
657
],
[
657,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telavancin"
]
],
[
[
"Nilotinib",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal discomfort"
],
[
"Abdominal discomfort",
"{u} (Side Effect) is... | Nilotinib (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Telavancin (Compound)
Nilotinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects w... |
DB00099 | DB00619 | 440 | 1,419 | [
"DDInter735",
"DDInter909"
] | Filgrastim | Imatinib | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
440,
24,
1419
]
],
[
[
440,
24,
1101
],
[
1101,
23,
1419
]
],
[
[
440,
24,
309
],
[
309,
63,
1419
]
],
[
[
440,
63,
599
],
[
599,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Imatinib
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilo... |
DB00222 | DB00621 | 245 | 1,026 | [
"DDInter825",
"DDInter1357"
] | Glimepiride | Oxandrolone | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A synthetic hormone with anabolic and androgenic properties. | Moderate | 1 | [
[
[
245,
24,
1026
]
],
[
[
245,
24,
1546
],
[
1546,
1,
1026
]
],
[
[
245,
21,
28698
],
[
28698,
60,
1026
]
],
[
[
245,
24,
1019
],
[
1019,... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Oxandrolone (Compound)
Glimepiride (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Oxandrolone (Compound)
Glimepiride may cause a mo... |
DB12839 | DB13152 | 919 | 249 | [
"DDInter1411",
"DDInter420"
] | Pegvaliase | Coagulation Factor IX Human | Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis_ that converts phenylalanine to ammonia and _trans_-cinnamic acid. Both the U.S. Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the treatment of adult patients with... | Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. | Moderate | 1 | [
[
[
919,
24,
249
]
],
[
[
919,
63,
1257
],
[
1257,
24,
350
],
[
350,
25,
249
]
],
[
[
919,
63,
1613
],
[
1613,
63,
350
],
[
350,
25,
... | [
[
[
"Pegvaliase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Coagulation Factor IX Human"
]
],
[
[
"Pegvaliase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegfilgras... | Pegvaliase may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim and Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib and Carfilzomib may lead to a major life threatening interaction when taken with Coagulation Factor IX Hu... |
DB00619 | DB01177 | 1,419 | 77 | [
"DDInter909",
"DDInter904"
] | Imatinib | Idarubicin | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1419,
24,
77
]
],
[
[
1419,
5,
11555
],
[
11555,
44,
77
]
],
[
[
1419,
6,
6017
],
[
6017,
45,
77
]
],
[
[
1419,
7,
2507
],
[
2507,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Imatinib",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) i... | Imatinib (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Idarubicin (Compound)
Imatinib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Imatinib (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is upregulated by Idarubicin (Compound)
I... |
DB09052 | DB14409 | 250 | 1,129 | [
"DDInter220",
"DDInter867"
] | Blinatumomab | Human adenovirus e serotype 4 strain cl-68578 antigen | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
250,
24,
1129
]
],
[
[
250,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
250,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
250,
24,
738
],
[
738,
... | [
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Blinatumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Blinatumomab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Blinatumomab may cause a moderate interaction that could exacerbate diseases when ... |
DB00624 | DB12130 | 1,561 | 1,017 | [
"DDInter1775",
"DDInter1094"
] | Testosterone | Lorlatinib | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1561,
24,
1017
]
],
[
[
1561,
63,
590
],
[
590,
24,
1017
]
],
[
[
1561,
25,
126
],
[
126,
24,
1017
]
],
[
[
1561,
24,
629
],
[
629,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
],
... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Testosterone may lead to a major life threatening interaction when taken with Warfarin and Warfarin may ... |
DB01142 | DB01235 | 1,264 | 1,191 | [
"DDInter593",
"DDInter1054"
] | Doxepin | Levodopa | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Minor | 0 | [
[
[
1264,
23,
1191
]
],
[
[
1264,
25,
584
],
[
584,
1,
1191
]
],
[
[
1264,
64,
874
],
[
874,
24,
1191
]
],
[
[
1264,
25,
871
],
[
871,
... | [
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levodopa"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levonordefrin"
],
[
"Levonordefrin",
... | Doxepin may lead to a major life threatening interaction when taken with Levonordefrin and Levonordefrin (Compound) resembles Levodopa (Compound)
Doxepin may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when take... |
DB00924 | DB01181 | 1,405 | 1,532 | [
"DDInter454",
"DDInter906"
] | Cyclobenzaprine | Ifosfamide | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1405,
24,
1532
]
],
[
[
1405,
6,
8374
],
[
8374,
45,
1532
]
],
[
[
1405,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
1405,
63,
1648
],
[
1... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Cyclobenzaprine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Cyclobenzaprine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ifosfamide (Compound)
Cyclobenzaprine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00222 | DB00701 | 245 | 1,091 | [
"DDInter825",
"DDInter90"
] | Glimepiride | Amprenavir | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Amprenavir is a protease inhibitor used to treat HIV infection. | Moderate | 1 | [
[
[
245,
24,
1091
]
],
[
[
245,
24,
34
],
[
34,
1,
1091
]
],
[
[
245,
6,
6017
],
[
6017,
45,
1091
]
],
[
[
245,
21,
28810
],
[
28810,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir (Compound) resembles Amprenavir (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Amprenavir (Compound)
Glimepiride (Compound) causes Gastrointestinal pain (Side ... |
DB01068 | DB09293 | 1,565 | 116 | [
"DDInter411",
"DDInter954"
] | Clonazepam | Iodide I-131 | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1565,
24,
116
]
],
[
[
1565,
63,
701
],
[
701,
24,
116
]
],
[
[
1565,
24,
516
],
[
516,
24,
116
]
],
[
[
1565,
1,
1418
],
[
1418,
... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and ... |
DB00381 | DB06273 | 376 | 980 | [
"DDInter79",
"DDInter1824"
] | Amlodipine | Tocilizumab | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
376,
24,
980
]
],
[
[
376,
40,
1428
],
[
1428,
24,
980
]
],
[
[
376,
1,
336
],
[
336,
24,
980
]
],
[
[
376,
25,
467
],
[
467,
24... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Amlodipine",
"{u} (Compound) resembles {v} (Compound)",
"Isradipine"
],
[
"Isradipine",
"{u} may cause a modera... | Amlodipine (Compound) resembles Isradipine (Compound) and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Amlodipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizuma... |
DB00717 | DB14568 | 1,197 | 982 | [
"DDInter1312",
"DDInter1000"
] | Norethisterone | Ivosidenib | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
1197,
24,
982
]
],
[
[
1197,
64,
1101
],
[
1101,
23,
982
]
],
[
[
1197,
40,
989
],
[
989,
24,
982
]
],
[
[
1197,
1,
1336
],
[
1336,
... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Norethisterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Be... | Norethisterone may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Norethisterone (Compound) resembles Progesterone (Compound) and Progesterone may cause a moderate interaction that could exac... |
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