drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB05239 | DB06717 | 866 | 875 | [
"DDInter425",
"DDInter778"
] | Cobimetinib | Fosaprepitant | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Major | 2 | [
[
[
866,
25,
875
]
],
[
[
866,
64,
723
],
[
723,
1,
875
]
],
[
[
866,
63,
1101
],
[
1101,
23,
875
]
],
[
[
866,
25,
760
],
[
760,
63... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aprepitant"
],
[
"Aprepitant",
"... | Cobimetinib may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical... |
DB00312 | DB06282 | 1,023 | 516 | [
"DDInter1423",
"DDInter1053"
] | Pentobarbital | Levocetirizine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1023,
24,
516
]
],
[
[
1023,
63,
1031
],
[
1031,
23,
516
]
],
[
[
1023,
63,
701
],
[
701,
24,
516
]
],
[
[
1023,
24,
1614
],
[
1614,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Levocetirizine
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Clemastin... |
DB00773 | DB05273 | 896 | 507 | [
"DDInter702",
"DDInter1638"
] | Etoposide | Samarium (153Sm) lexidronam | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
896,
25,
507
]
],
[
[
896,
24,
248
],
[
248,
24,
507
]
],
[
[
896,
24,
270
],
[
270,
63,
507
]
],
[
[
896,
63,
1101
],
[
1101,
2... | [
[
[
"Etoposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Etoposide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB06674 | DB11989 | 908 | 1,434 | [
"DDInter837",
"DDInter183"
] | Golimumab | Benznidazole | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
908,
24,
1434
]
],
[
[
908,
24,
788
],
[
788,
24,
1434
]
],
[
[
908,
25,
375
],
[
375,
24,
1434
]
],
[
[
908,
64,
309
],
[
309,
... | [
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
[
... | Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Golimumab may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizu... |
DB00286 | DB08882 | 380 | 1,281 | [
"DDInter439",
"DDInter1070"
] | Conjugated estrogens | Linagliptin | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
380,
24,
1281
]
],
[
[
380,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
380,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
380,
21,
28966
],
[
28966,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogli... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Conjugated estrogens (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Conjugated estrogens (Compound) causes Upper... |
DB00215 | DB09054 | 1,230 | 384 | [
"DDInter388",
"DDInter905"
] | Citalopram | Idelalisib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Minor | 0 | [
[
[
1230,
23,
384
]
],
[
[
1230,
25,
222
],
[
222,
23,
384
]
],
[
[
1230,
1,
318
],
[
318,
23,
384
]
],
[
[
1230,
25,
1618
],
[
1618,
... | [
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Idelalisib"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramine... | Citalopram may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Citalopram (Compound) resembles Escitalopram (Compound) and Es
Citalopram may lead to a major life threatening interaction when... |
DB00909 | DB01233 | 306 | 1,311 | [
"DDInter1971",
"DDInter1197"
] | Zonisamide | Metoclopramide | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
306,
24,
1311
]
],
[
[
306,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
306,
63,
1010
],
[
1010,
23,
1311
]
],
[
[
306,
63,
629
],
[
629,
... | [
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Zonisamide",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) i... | Zonisamide (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a minor interaction that can limit clinical effects when taken with Met... |
DB00880 | DB01164 | 359 | 803 | [
"DDInter360",
"DDInter272"
] | Chlorothiazide | Calcium chloride | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in ... | Moderate | 1 | [
[
[
359,
24,
803
]
],
[
[
359,
21,
29196
],
[
29196,
60,
803
]
],
[
[
359,
40,
504
],
[
504,
24,
803
]
],
[
[
359,
62,
1545
],
[
1545,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium chloride"
]
],
[
[
"Chlorothiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
"{u} (... | Chlorothiazide (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Calcium chloride (Compound)
Chlorothiazide (Compound) resembles Hydrochlorothiazide (Compound) and Hydro
Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Oxytetracycline an... |
DB11793 | DB15233 | 738 | 1,650 | [
"DDInter1297",
"DDInter142"
] | Niraparib | Avapritinib | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
738,
24,
1650
]
],
[
[
738,
63,
1101
],
[
1101,
24,
1650
]
],
[
[
738,
24,
270
],
[
270,
24,
1650
]
],
[
[
738,
64,
908
],
[
908,
... | [
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocreli... |
DB11967 | DB11979 | 710 | 1,320 | [
"DDInter210",
"DDInter625"
] | Binimetinib | Elagolix | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
710,
24,
1320
]
],
[
[
710,
63,
271
],
[
271,
23,
1320
]
],
[
[
710,
63,
79
],
[
79,
24,
1320
]
],
[
[
710,
64,
1213
],
[
1213,
... | [
[
[
"Binimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Binimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirabegron"
],
[
... | Binimetinib may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Elagolix
Binimetinib may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib... |
DB00424 | DB00604 | 19 | 1,425 | [
"DDInter896",
"DDInter385"
] | Hyoscyamine | Cisapride | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Moderate | 1 | [
[
[
19,
24,
1425
]
],
[
[
19,
24,
1311
],
[
1311,
1,
1425
]
],
[
[
19,
24,
924
],
[
924,
64,
1425
]
],
[
[
19,
63,
475
],
[
475,
23,... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisapride"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Cisapride (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone may lead to a major life threate... |
DB00773 | DB09054 | 896 | 384 | [
"DDInter702",
"DDInter905"
] | Etoposide | Idelalisib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
896,
24,
384
]
],
[
[
896,
24,
555
],
[
555,
23,
384
]
],
[
[
896,
62,
307
],
[
307,
23,
384
]
],
[
[
896,
24,
1618
],
[
1618,
2... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Netupitant and Netupitant may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Etoposide may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may... |
DB06077 | DB06335 | 879 | 761 | [
"DDInter1102",
"DDInter1646"
] | Lumateperone | Saxagliptin | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
879,
24,
761
]
],
[
[
879,
63,
104
],
[
104,
24,
761
]
],
[
[
879,
64,
1573
],
[
1573,
24,
761
]
],
[
[
879,
24,
1296
],
[
1296,
... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Lumateperone may lead to a major life threatening interaction when taken with Prednisone and Prednisone m... |
DB00331 | DB09135 | 1,645 | 1,211 | [
"DDInter1164",
"DDInter967"
] | Metformin | Ioxilan | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
1645,
25,
1211
]
],
[
[
1645,
24,
863
],
[
863,
24,
1211
]
],
[
[
1645,
63,
1028
],
[
1028,
24,
1211
]
],
[
[
1645,
25,
471
],
[
471,
... | [
[
[
"Metformin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiloride"
],
[
"Amiloride",
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Amiloride and Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Torasemide and Torasemide ma... |
DB00361 | DB01004 | 134 | 563 | [
"DDInter1939",
"DDInter806"
] | Vinorelbine | Ganciclovir | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Moderate | 1 | [
[
[
134,
24,
563
]
],
[
[
134,
24,
248
],
[
248,
40,
563
]
],
[
[
134,
21,
29233
],
[
29233,
60,
563
]
],
[
[
134,
24,
36
],
[
36,
6... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Vinorelbine (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Ganciclovir (Compound)
Vinorelbin... |
DB01105 | DB01186 | 222 | 107 | [
"DDInter1665",
"DDInter1430"
] | Sibutramine | Pergolide | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic tr... | Moderate | 1 | [
[
[
222,
24,
107
]
],
[
[
222,
6,
8374
],
[
8374,
45,
107
]
],
[
[
222,
21,
28757
],
[
28757,
60,
107
]
],
[
[
222,
63,
832
],
[
832,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pergolide"
]
],
[
[
"Sibutramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Sibutramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pergolide (Compound)
Sibutramine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Pergolide (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and... |
DB00443 | DB01097 | 251 | 1,377 | [
"DDInter195",
"DDInter1033"
] | Betamethasone | Leflunomide | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
251,
25,
1377
]
],
[
[
251,
5,
11577
],
[
11577,
44,
1377
]
],
[
[
251,
18,
18226
],
[
18226,
57,
1377
]
],
[
[
251,
21,
28701
],
[
28... | [
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Betamethasone",
"{u} (Compound) treats {v} (Disease)",
"rheumatoid arthritis"
],
[
"rheumatoid arthritis",
"{u} (Disease) i... | Betamethasone (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Leflunomide (Compound)
Betamethasone (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Leflunomide (Compound)
Betamethasone (Compound) causes Discomfort (Side Effect) and Discomfort (... |
DB01024 | DB01155 | 1,096 | 872 | [
"DDInter1252",
"DDInter813"
] | Mycophenolic acid | Gemifloxacin | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
1096,
24,
872
]
],
[
[
1096,
63,
739
],
[
739,
1,
872
]
],
[
[
1096,
24,
956
],
[
956,
1,
872
]
],
[
[
1096,
24,
945
],
[
945,
4... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxaci... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin (Compound) resembles ... |
DB00382 | DB08895 | 62 | 976 | [
"DDInter1734",
"DDInter1825"
] | Tacrine | Tofacitinib | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
62,
24,
976
]
],
[
[
62,
24,
868
],
[
868,
24,
976
]
],
[
[
62,
24,
1297
],
[
1297,
63,
976
]
],
[
[
62,
23,
848
],
[
848,
24,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodr... |
DB01133 | DB09322 | 1,104 | 1,114 | [
"DDInter1808",
"DDInter1966"
] | Tiludronic acid | Zinc sulfate | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Moderate | 1 | [
[
[
1104,
24,
1114
]
],
[
[
1104,
24,
1596
],
[
1596,
23,
1114
]
],
[
[
1104,
24,
428
],
[
428,
62,
1114
]
],
[
[
1104,
24,
1596
],
[
1596... | [
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
... | Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Fe... |
DB00738 | DB06788 | 485 | 1,616 | [
"DDInter1420",
"DDInter864"
] | Pentamidine | Histrelin | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
485,
24,
1616
]
],
[
[
485,
23,
112
],
[
112,
23,
1616
]
],
[
[
485,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
485,
24,
623
],
[
623,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Ri... |
DB00438 | DB00738 | 149 | 485 | [
"DDInter330",
"DDInter1420"
] | Ceftazidime | Pentamidine | Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of esse... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
149,
24,
485
]
],
[
[
149,
21,
28981
],
[
28981,
60,
485
]
],
[
[
149,
24,
1662
],
[
1662,
63,
485
]
],
[
[
149,
24,
1287
],
[
1287,
... | [
[
[
"Ceftazidime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Ceftazidime",
"{u} (Compound) causes {v} (Side Effect)",
"Renal impairment"
],
[
"Renal impairment",
"{u} (Sid... | Ceftazidime (Compound) causes Renal impairment (Side Effect) and Renal impairment (Side Effect) is caused by Pentamidine (Compound)
Ceftazidime may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate d... |
DB00254 | DB00485 | 964 | 916 | [
"DDInter598",
"DDInter541"
] | Doxycycline | Dicloxacillin | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | One of the penicillins which is resistant to penicillinase. | Moderate | 1 | [
[
[
964,
24,
916
]
],
[
[
964,
24,
1681
],
[
1681,
40,
916
]
],
[
[
964,
24,
339
],
[
339,
1,
916
]
],
[
[
964,
6,
8374
],
[
8374,
4... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicloxacillin"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mezlocillin"
],
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Mezlocillin and Mezlocillin (Compound) resembles Dicloxacillin (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Bacampicillin and Bacampicillin (Compound) resembles Dicloxaci... |
DB00422 | DB06704 | 895 | 247 | [
"DDInter1189",
"DDInter951"
] | Methylphenidate | Iobenguane (I-123) | Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cogni... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
895,
37,
247
]
],
[
[
895,
6,
7390
],
[
7390,
45,
247
]
],
[
[
895,
21,
28787
],
[
28787,
60,
247
]
],
[
[
895,
24,
820
],
[
820,
... | [
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Methylphenidate",
"{u} (Compound) binds {v} (Gene)",
... | Methylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Methylphenidate may lead to a major life threatening interaction when taken with Iobenguane
Methylphenidate (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Methylphenidate (C... |
DB00872 | DB12267 | 1,080 | 1,476 | [
"DDInter438",
"DDInter233"
] | Conivaptan | Brigatinib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
1080,
25,
1476
]
],
[
[
1080,
25,
1135
],
[
1135,
23,
1476
]
],
[
[
1080,
63,
168
],
[
168,
23,
1476
]
],
[
[
1080,
25,
629
],
[
629,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Conivaptan may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a mi... |
DB01018 | DB01240 | 1,364 | 885 | [
"DDInter847",
"DDInter657"
] | Guanfacine | Epoprostenol | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1364,
24,
885
]
],
[
[
1364,
63,
1061
],
[
1061,
1,
885
]
],
[
[
1364,
6,
6017
],
[
6017,
45,
885
]
],
[
[
1364,
21,
28936
],
[
28936,... | [
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Guanfacine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epoprostenol (Compound)
Guanfacine (Compound) causes Hyperhidrosis (Side Effect) a... |
DB00176 | DB00975 | 529 | 1,317 | [
"DDInter770",
"DDInter573"
] | Fluvoxamine | Dipyridamole | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
529,
24,
1317
]
],
[
[
529,
6,
4973
],
[
4973,
45,
1317
]
],
[
[
529,
21,
28748
],
[
28748,
60,
1317
]
],
[
[
529,
25,
1031
],
[
1031,... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Fluvoxamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dipyridamole (Compound)
Fluvoxamine (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Dipyridamole (Compound)
Fluvoxamine may lead to a major life threatening interaction when taken with Theophylline and Theophylline may... |
DB00019 | DB00853 | 1,257 | 1,686 | [
"DDInter1405",
"DDInter1762"
] | Pegfilgrastim | Temozolomide | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Moderate | 1 | [
[
[
1257,
24,
1686
]
],
[
[
1257,
24,
970
],
[
970,
24,
1686
]
],
[
[
1257,
24,
1330
],
[
1330,
63,
1686
]
],
[
[
1257,
24,
770
],
[
770,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temozolomide"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluorouracil"
]... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil and Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozolomide
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab... |
DB04951 | DB12500 | 187 | 283 | [
"DDInter1477",
"DDInter714"
] | Pirfenidone | Fedratinib | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
187,
24,
283
]
],
[
[
187,
24,
271
],
[
271,
23,
283
]
],
[
[
187,
24,
1339
],
[
1339,
62,
283
]
],
[
[
187,
24,
327
],
[
327,
2... | [
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirabegron"
],
[
... | Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Berotralstat and Bero... |
DB00092 | DB08868 | 58 | 1,011 | [
"DDInter40",
"DDInter737"
] | Alefacept | Fingolimod | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
58,
25,
1011
]
],
[
[
58,
24,
748
],
[
748,
63,
1011
]
],
[
[
58,
24,
1136
],
[
1136,
24,
1011
]
],
[
[
58,
25,
976
],
[
976,
64... | [
[
[
"Alefacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Anthrax... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Denosumab and... |
DB00278 | DB08901 | 291 | 1,468 | [
"DDInter117",
"DDInter1492"
] | Argatroban | Ponatinib | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
291,
25,
1468
]
],
[
[
291,
6,
7524
],
[
7524,
45,
1468
]
],
[
[
291,
21,
29425
],
[
29425,
60,
1468
]
],
[
[
291,
63,
1230
],
[
1230,... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Argatroban",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Ponatini... | Argatroban (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ponatinib (Compound)
Argatroban (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Ponatinib (Compound)
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01101 | DB14783 | 60 | 287 | [
"DDInter285",
"DDInter574"
] | Capecitabine | Diroximel fumarate | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
60,
24,
287
]
],
[
[
60,
24,
384
],
[
384,
24,
287
]
],
[
[
60,
63,
995
],
[
995,
24,
287
]
],
[
[
60,
62,
147
],
[
147,
24,
... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyur... |
DB00820 | DB01612 | 402 | 1,637 | [
"DDInter1736",
"DDInter92"
] | Tadalafil | Amyl Nitrite | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Major | 2 | [
[
[
402,
25,
1637
]
],
[
[
402,
23,
714
],
[
714,
24,
1637
]
],
[
[
402,
62,
1061
],
[
1061,
24,
1637
]
],
[
[
402,
24,
1053
],
[
1053,
... | [
[
[
"Tadalafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Tadalafil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Iloprost"
],
[
"Iloprost",
... | Tadalafil may cause a minor interaction that can limit clinical effects when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Tadalafil may cause a minor interaction that can limit clinical effects when taken with Treprostinil and Treprostinil... |
DB08865 | DB11642 | 1,593 | 938 | [
"DDInter448",
"DDInter1480"
] | Crizotinib | Pitolisant | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Major | 2 | [
[
[
1593,
25,
938
]
],
[
[
1593,
63,
112
],
[
112,
23,
938
]
],
[
[
1593,
25,
760
],
[
760,
24,
938
]
],
[
[
1593,
24,
28
],
[
28,
2... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pitolisant"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Crizotinib may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may ca... |
DB00655 | DB01261 | 559 | 170 | [
"DDInter682",
"DDInter1679"
] | Estrone | Sitagliptin | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
559,
24,
170
]
],
[
[
559,
6,
8374
],
[
8374,
45,
170
]
],
[
[
559,
21,
28921
],
[
28921,
60,
170
]
],
[
[
559,
24,
52
],
[
52,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Estrone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Estrone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sitagliptin (Compound)
Estrone (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sitagliptin (Compound)
Estrone may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutid... |
DB00461 | DB09054 | 598 | 384 | [
"DDInter1254",
"DDInter905"
] | Nabumetone | Idelalisib | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
598,
24,
384
]
],
[
[
598,
24,
222
],
[
222,
23,
384
]
],
[
[
598,
25,
1618
],
[
1618,
24,
384
]
],
[
[
598,
63,
305
],
[
305,
2... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Nabumetone may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may ca... |
DB06448 | DB06697 | 171 | 436 | [
"DDInter1087",
"DDInter121"
] | Lonafarnib | Artemether | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Major | 2 | [
[
[
171,
25,
436
]
],
[
[
171,
63,
353
],
[
353,
24,
436
]
],
[
[
171,
25,
283
],
[
283,
63,
436
]
],
[
[
171,
64,
1220
],
[
1220,
2... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Artemether"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Griseofulvin"
],
[
"Griseofu... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Artemether
Lonafarnib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may ca... |
DB00570 | DB08816 | 147 | 578 | [
"DDInter1936",
"DDInter1802"
] | Vinblastine | Ticagrelor | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
147,
24,
578
]
],
[
[
147,
6,
4973
],
[
4973,
45,
578
]
],
[
[
147,
21,
28762
],
[
28762,
60,
578
]
],
[
[
147,
24,
700
],
[
700,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Vinblastine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Vinblastine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ticagrelor (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Ato... |
DB00544 | DB00970 | 970 | 0 | [
"DDInter757",
"DDInter466"
] | Fluorouracil | Dactinomycin | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Moderate | 1 | [
[
[
970,
24,
0
]
],
[
[
970,
5,
11656
],
[
11656,
44,
0
]
],
[
[
970,
6,
17404
],
[
17404,
45,
0
]
],
[
[
970,
6,
6616
],
[
6616,
57... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dactinomycin"
]
],
[
[
"Fluorouracil",
"{u} (Compound) treats {v} (Disease)",
"skin cancer"
],
[
"skin cancer",
"{u} (Disease) is tr... | Fluorouracil (Compound) treats skin cancer (Disease) and skin cancer (Disease) is treated by Dactinomycin (Compound)
Fluorouracil (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dactinomycin (Compound)
Fluorouracil (Compound) binds UMPS (Gene) and UMPS (Gene) is downregulated by Dactinomycin (Compound)
Fluor... |
DB00795 | DB09293 | 50 | 116 | [
"DDInter1725",
"DDInter954"
] | Sulfasalazine | Iodide I-131 | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
50,
24,
116
]
],
[
[
50,
62,
682
],
[
682,
24,
116
]
],
[
[
50,
64,
126
],
[
126,
24,
116
]
],
[
[
50,
25,
1527
],
[
1527,
24,
... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Sulfasalazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Thiopental"
],
... | Sulfasalazine may cause a minor interaction that can limit clinical effects when taken with Thiopental and Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Sulfasalazine may lead to a major life threatening interaction when taken with Warfarin and Warfarin may caus... |
DB00238 | DB08820 | 188 | 1,478 | [
"DDInter1285",
"DDInter997"
] | Nevirapine | Ivacaftor | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
188,
24,
1478
]
],
[
[
188,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
188,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
188,
24,
1135
],
[
1135,... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Nevirapine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol... |
DB00328 | DB00374 | 831 | 1,061 | [
"DDInter921",
"DDInter1852"
] | Indomethacin | Treprostinil | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Moderate | 1 | [
[
[
831,
24,
1061
]
],
[
[
831,
24,
885
],
[
885,
40,
1061
]
],
[
[
831,
6,
6017
],
[
6017,
45,
1061
]
],
[
[
831,
6,
4789
],
[
4789,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Indomethacin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Treprostinil (Compound)
Indomethacin (Compound) binds PPARG (Gene) and PPARG (... |
DB00331 | DB00852 | 1,645 | 1,445 | [
"DDInter1164",
"DDInter1545"
] | Metformin | Pseudoephedrine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
1645,
24,
1445
]
],
[
[
1645,
63,
73
],
[
73,
24,
1445
]
],
[
[
1645,
24,
280
],
[
280,
40,
1445
]
],
[
[
1645,
21,
28763
],
[
28763,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Mephentermine an... |
DB00278 | DB06779 | 291 | 365 | [
"DDInter117",
"DDInter470"
] | Argatroban | Dalteparin | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
291,
25,
365
]
],
[
[
291,
23,
539
],
[
539,
62,
365
]
],
[
[
291,
24,
1496
],
[
1496,
63,
365
]
],
[
[
291,
24,
1100
],
[
1100,
... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Argatroban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Argatroban may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may... |
DB06372 | DB13007 | 259 | 1,060 | [
"DDInter1594",
"DDInter642"
] | Rilonacept | Enfortumab vedotin | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
259,
24,
1060
]
],
[
[
259,
24,
270
],
[
270,
24,
1060
]
],
[
[
259,
63,
58
],
[
58,
24,
1060
]
],
[
[
259,
64,
980
],
[
980,
24... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
],... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Alefacept a... |
DB00850 | DB01261 | 1,630 | 170 | [
"DDInter1432",
"DDInter1679"
] | Perphenazine | Sitagliptin | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1630,
24,
170
]
],
[
[
1630,
6,
3486
],
[
3486,
45,
170
]
],
[
[
1630,
7,
6448
],
[
6448,
57,
170
]
],
[
[
1630,
21,
28921
],
[
28921,... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Perphenazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compou... | Perphenazine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sitagliptin (Compound)
Perphenazine (Compound) upregulates CTSD (Gene) and CTSD (Gene) is downregulated by Sitagliptin (Compound)
Perphenazine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sitagliptin (Compoun... |
DB00598 | DB00668 | 1,523 | 874 | [
"DDInter1013",
"DDInter652"
] | Labetalol | Epinephrine | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Major | 2 | [
[
[
1523,
25,
874
]
],
[
[
1523,
63,
1636
],
[
1636,
1,
874
]
],
[
[
1523,
25,
688
],
[
688,
63,
874
]
],
[
[
1523,
24,
1148
],
[
1148,
... | [
[
[
"Labetalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[
"Phenylep... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Labetalol may lead to a major life threatening interaction when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbat... |
DB08875 | DB12887 | 1,618 | 1,598 | [
"DDInter262",
"DDInter1750"
] | Cabozantinib | Tazemetostat | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
1618,
24,
1598
]
],
[
[
1618,
64,
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],
[
594,
24,
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],
[
[
1618,
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[
985,
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],
[
[
1618,
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738
],
[
738,
... | [
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Cabozantinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
],
[
"Bosut... | Cabozantinib may lead to a major life threatening interaction when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Cabozantinib may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a moderat... |
DB00015 | DB00712 | 582 | 1,274 | [
"DDInter1585",
"DDInter763"
] | Reteplase | Flurbiprofen | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
582,
24,
1274
]
],
[
[
582,
24,
935
],
[
935,
63,
1274
]
],
[
[
582,
23,
297
],
[
297,
62,
1274
]
],
[
[
582,
24,
529
],
[
529,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Reteplase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cau... |
DB00176 | DB08881 | 529 | 868 | [
"DDInter770",
"DDInter1925"
] | Fluvoxamine | Vemurafenib | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
529,
24,
868
]
],
[
[
529,
6,
8374
],
[
8374,
45,
868
]
],
[
[
529,
7,
3466
],
[
3466,
46,
868
]
],
[
[
529,
18,
6717
],
[
6717,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Fluvoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Fluvoxamine (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Vemurafenib (Compound)
Fluvoxamine (Compound) downregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Vemurafenib (Compound)
Fluvox... |
DB01232 | DB08871 | 1,327 | 36 | [
"DDInter1640",
"DDInter666"
] | Saquinavir | Eribulin | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
1327,
25,
36
]
],
[
[
1327,
64,
973
],
[
973,
24,
36
]
],
[
[
1327,
25,
820
],
[
820,
24,
36
]
],
[
[
1327,
63,
168
],
[
168,
24... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
],
[
"Paclitaxel",
"{u} may... | Saquinavir may lead to a major life threatening interaction when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Saquinavir may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a moderate inte... |
DB05679 | DB14004 | 1,683 | 398 | [
"DDInter1907",
"DDInter1806"
] | Ustekinumab | Tildrakizumab | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis . The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psorias... | Moderate | 1 | [
[
[
1683,
24,
398
]
],
[
[
1683,
23,
1114
],
[
1114,
23,
398
]
],
[
[
1683,
62,
1461
],
[
1461,
23,
398
]
],
[
[
1683,
63,
58
],
[
58,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tildrakizumab"
]
],
[
[
"Ustekinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
... | Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Tildrakizumab
Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vita... |
DB06212 | DB13620 | 165 | 948 | [
"DDInter1833",
"DDInter1499"
] | Tolvaptan | Potassium gluconate | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Moderate | 1 | [
[
[
165,
24,
948
]
],
[
[
165,
24,
554
],
[
554,
62,
176
],
[
176,
23,
948
]
],
[
[
165,
63,
1621
],
[
1621,
62,
176
],
[
176,
23,
... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium perchlorat... | Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate and Potassium perchlorate may cause a minor interaction that can limit clinical effects when taken with Insulin glargine and Insulin glargine may cause a minor interaction that can limit clinical effects when... |
DB00108 | DB12001 | 1,066 | 564 | [
"DDInter1268",
"DDInter7"
] | Natalizumab | Abemaciclib | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
1066,
25,
564
]
],
[
[
1066,
24,
748
],
[
748,
24,
564
]
],
[
[
1066,
64,
58
],
[
58,
24,
564
]
],
[
[
1066,
25,
259
],
[
259,
2... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Natalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"An... | Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Natalizumab may lead to a major life threatening interaction when taken with Alefacept and Alefacept... |
DB00448 | DB11703 | 1,215 | 405 | [
"DDInter1022",
"DDInter9"
] | Lansoprazole | Acalabrutinib | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1215,
25,
405
]
],
[
[
1215,
63,
1324
],
[
1324,
24,
405
]
],
[
[
1215,
64,
1230
],
[
1230,
24,
405
]
],
[
[
1215,
24,
1375
],
[
1375,... | [
[
[
"Lansoprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
"T... | Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Lansoprazole may lead to a major life threatening interaction when taken with Citalopram and Citalopram... |
DB00222 | DB04861 | 245 | 1,592 | [
"DDInter825",
"DDInter1271"
] | Glimepiride | Nebivolol | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
245,
24,
1592
]
],
[
[
245,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
245,
24,
1283
],
[
1283,
23,
1592
]
],
[
[
245,
24,
460
],
[
460,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cause... | Glimepiride (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with ... |
DB01238 | DB08871 | 673 | 36 | [
"DDInter118",
"DDInter666"
] | Aripiprazole | Eribulin | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
673,
24,
36
]
],
[
[
673,
63,
1424
],
[
1424,
24,
36
]
],
[
[
673,
24,
820
],
[
820,
24,
36
]
],
[
[
673,
24,
384
],
[
384,
63,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazi... |
DB00341 | DB00494 | 1,242 | 1,533 | [
"DDInter343",
"DDInter646"
] | Cetirizine | Entacapone | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Moderate | 1 | [
[
[
1242,
24,
1533
]
],
[
[
1242,
63,
1062
],
[
1062,
1,
1533
]
],
[
[
1242,
21,
29305
],
[
29305,
60,
1533
]
],
[
[
1242,
24,
770
],
[
77... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entacapone"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolcapone"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Tolcapone and Tolcapone (Compound) resembles Entacapone (Compound)
Cetirizine (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Entacapone (Compound)
Cetirizine may cause a moderate interaction th... |
DB01242 | DB08875 | 1,237 | 1,618 | [
"DDInter410",
"DDInter262"
] | Clomipramine | Cabozantinib | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1237,
25,
1618
]
],
[
[
1237,
62,
112
],
[
112,
23,
1618
]
],
[
[
1237,
24,
1662
],
[
1662,
63,
1618
]
],
[
[
1237,
63,
480
],
[
480,
... | [
[
[
"Clomipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Clomipramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Clomipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric ... |
DB00848 | DB11817 | 281 | 1,259 | [
"DDInter1044",
"DDInter165"
] | Levamisole | Baricitinib | Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this,... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
281,
25,
1259
]
],
[
[
281,
24,
949
],
[
949,
24,
1259
]
],
[
[
281,
24,
1129
],
[
1129,
63,
1259
]
],
[
[
281,
25,
1011
],
[
1011,
... | [
[
[
"Levamisole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Levamisole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formal... | Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Levamisole ... |
DB00842 | DB06723 | 686 | 115 | [
"DDInter1359",
"DDInter58"
] | Oxazepam | Aluminum hydroxide | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
686,
23,
115
]
],
[
[
686,
21,
28845
],
[
28845,
60,
115
]
],
[
[
686,
40,
1565
],
[
1565,
23,
115
]
],
[
[
686,
24,
401
],
[
401,
... | [
[
[
"Oxazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Oxazepam",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema"
],
[
"Oedema",
"{u} (Side Effect) is caused b... | Oxazepam (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Aluminum hydroxide (Compound)
Oxazepam (Compound) resembles Clonazepam (Compound) and Clonazepam may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Oxazepam may cause a moderate interactio... |
DB00286 | DB00451 | 380 | 542 | [
"DDInter439",
"DDInter1064"
] | Conjugated estrogens | Levothyroxine | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
380,
24,
542
]
],
[
[
380,
63,
1152
],
[
1152,
1,
542
]
],
[
[
380,
6,
15333
],
[
15333,
45,
542
]
],
[
[
380,
21,
28957
],
[
28957,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liot... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Levothyroxine (Compound)
Conjugated estrogens (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Levothyroxine (Compound)
Conjugated estrogens (Compound) ca... |
DB13179 | DB14568 | 68 | 982 | [
"DDInter1882",
"DDInter1000"
] | Troleandomycin | Ivosidenib | A macrolide antibiotic that is similar to erythromycin. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
68,
25,
982
]
],
[
[
68,
63,
168
],
[
168,
23,
982
]
],
[
[
68,
62,
1101
],
[
1101,
23,
982
]
],
[
[
68,
64,
976
],
[
976,
24,
... | [
[
[
"Troleandomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Troleandomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bo... | Troleandomycin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Troleandomycin may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Be... |
DB00514 | DB08815 | 506 | 154 | [
"DDInter527",
"DDInter1104"
] | Dextromethorphan | Lurasidone | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
506,
24,
154
]
],
[
[
506,
6,
8374
],
[
8374,
45,
154
]
],
[
[
506,
21,
28730
],
[
28730,
60,
154
]
],
[
[
506,
24,
100
],
[
100,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Dextromethorphan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} ... | Dextromethorphan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lurasidone (Compound)
Dextromethorphan (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Lurasidone (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases... |
DB00283 | DB01121 | 701 | 94 | [
"DDInter395",
"DDInter1437"
] | Clemastine | Phenacemide | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. | Moderate | 1 | [
[
[
701,
24,
94
]
],
[
[
701,
24,
551
],
[
551,
1,
94
]
],
[
[
701,
24,
1614
],
[
1614,
24,
94
]
],
[
[
701,
24,
1264
],
[
1264,
63,... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Phenacemide (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could ex... |
DB01268 | DB15035 | 1,151 | 503 | [
"DDInter1731",
"DDInter1959"
] | Sunitinib | Zanubrutinib | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1151,
25,
503
]
],
[
[
1151,
24,
1094
],
[
1094,
24,
503
]
],
[
[
1151,
25,
982
],
[
982,
24,
503
]
],
[
[
1151,
63,
1324
],
[
1324,
... | [
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
[
"Metrelept... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Sunitinib may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may caus... |
DB00641 | DB09118 | 467 | 1,580 | [
"DDInter1675",
"DDInter1711"
] | Simvastatin | Stiripentol | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
467,
24,
1580
]
],
[
[
467,
24,
466
],
[
466,
62,
1580
]
],
[
[
467,
24,
283
],
[
283,
63,
1580
]
],
[
[
467,
63,
168
],
[
168,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Stiripentol
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and F... |
DB00321 | DB08871 | 21 | 36 | [
"DDInter78",
"DDInter666"
] | Amitriptyline | Eribulin | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
21,
24,
36
]
],
[
[
21,
24,
1424
],
[
1424,
24,
36
]
],
[
[
21,
35,
820
],
[
820,
24,
36
]
],
[
[
21,
63,
600
],
[
600,
24,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Amitriptyline (Compound) resembles Alimemazine (Compound) and Amitriptyline may cause a moderate interaction that cou... |
DB00674 | DB06176 | 1,516 | 1,342 | [
"DDInter802",
"DDInter1616"
] | Galantamine | Romidepsin | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1516,
24,
1342
]
],
[
[
1516,
24,
112
],
[
112,
23,
1342
]
],
[
[
1516,
24,
485
],
[
485,
24,
1342
]
],
[
[
1516,
24,
1616
],
[
1616,
... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and... |
DB00431 | DB01577 | 1,503 | 1,529 | [
"DDInter1072",
"DDInter1161"
] | Lindane | Metamfetamine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
1503,
24,
1529
]
],
[
[
1503,
24,
939
],
[
939,
40,
1529
]
],
[
[
1503,
63,
80
],
[
80,
40,
1529
]
],
[
[
1503,
24,
93
],
[
93,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Metamfetamine (Co... |
DB00196 | DB01234 | 600 | 1,220 | [
"DDInter743",
"DDInter513"
] | Fluconazole | Dexamethasone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
600,
24,
1220
]
],
[
[
600,
24,
870
],
[
870,
1,
1220
]
],
[
[
600,
24,
175
],
[
175,
40,
1220
]
],
[
[
600,
6,
21998
],
[
21998,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles D... |
DB08899 | DB12010 | 129 | 214 | [
"DDInter649",
"DDInter785"
] | Enzalutamide | Fostamatinib | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
129,
25,
214
]
],
[
[
129,
64,
976
],
[
976,
24,
214
]
],
[
[
129,
63,
723
],
[
723,
24,
214
]
],
[
[
129,
25,
861
],
[
861,
63,... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
... | Enzalutamide may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant ma... |
DB00106 | DB01166 | 618 | 477 | [
"DDInter4",
"DDInter379"
] | Abarelix | Cilostazol | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
618,
24,
477
]
],
[
[
618,
23,
112
],
[
112,
23,
477
]
],
[
[
618,
24,
1585
],
[
1585,
24,
477
]
],
[
[
618,
24,
1079
],
[
1079,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Adenosine and Adenosine... |
DB00374 | DB01174 | 1,061 | 697 | [
"DDInter1852",
"DDInter1442"
] | Treprostinil | Phenobarbital | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
1061,
24,
697
]
],
[
[
1061,
63,
362
],
[
362,
1,
697
]
],
[
[
1061,
6,
6017
],
[
6017,
45,
697
]
],
[
[
1061,
21,
29106
],
[
29106,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound)
Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Phenobarbital (Compound)
Treprostinil (Compound) causes Myalgia (Side Effect) and M... |
DB00877 | DB11932 | 629 | 327 | [
"DDInter1678",
"DDInter3"
] | Sirolimus | Abametapir (topical) | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
629,
24,
327
]
],
[
[
629,
24,
124
],
[
124,
63,
327
]
],
[
[
629,
63,
1601
],
[
1601,
24,
327
]
],
[
[
629,
24,
868
],
[
868,
2... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Sirolimus may ... |
DB00816 | DB01599 | 1,674 | 1,232 | [
"DDInter1346",
"DDInter1523"
] | Orciprenaline | Probucol | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
1674,
24,
1232
]
],
[
[
1674,
7,
8587
],
[
8587,
46,
1232
]
],
[
[
1674,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
1674,
24,
927
],
[
927,... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Orciprenaline",
"{u} (Compound) upregulates {v} (Gene)",
"RRS1"
],
[
"RRS1",
"{u} (Gene) is upregulated by {v} ... | Orciprenaline (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Probucol (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Orcipr... |
DB00060 | DB05015 | 912 | 1,077 | [
"DDInter947",
"DDInter174"
] | Interferon beta-1a | Belinostat | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Moderate | 1 | [
[
[
912,
24,
1077
]
],
[
[
912,
24,
482
],
[
482,
24,
1077
]
],
[
[
912,
24,
637
],
[
637,
63,
1077
]
],
[
[
912,
63,
1560
],
[
1560,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belinostat"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Belinostat
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Aspar... |
DB00312 | DB11837 | 1,023 | 1,297 | [
"DDInter1423",
"DDInter1351"
] | Pentobarbital | Osilodrostat | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1023,
24,
1297
]
],
[
[
1023,
24,
1135
],
[
1135,
23,
1297
]
],
[
[
1023,
24,
466
],
[
466,
62,
1297
]
],
[
[
1023,
24,
1320
],
[
1320... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and ... |
DB00398 | DB01125 | 79 | 279 | [
"DDInter1702",
"DDInter98"
] | Sorafenib | Anisindione | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Moderate | 1 | [
[
[
79,
24,
279
]
],
[
[
79,
24,
918
],
[
918,
62,
279
]
],
[
[
79,
24,
913
],
[
913,
63,
279
]
],
[
[
79,
24,
1195
],
[
1195,
24,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Anisindione
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apal... |
DB01044 | DB01592 | 246 | 1,596 | [
"DDInter809",
"DDInter975"
] | Gatifloxacin | Iron | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
246,
24,
1596
]
],
[
[
246,
21,
29024
],
[
29024,
60,
1596
]
],
[
[
246,
24,
1193
],
[
1193,
62,
1596
]
],
[
[
246,
63,
1096
],
[
1096... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Hypertension"
],
[
"Hypertension",
"{u} (Side Effect) is ... | Gatifloxacin (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Iron (Compound)
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken wi... |
DB04865 | DB08895 | 4 | 976 | [
"DDInter1335",
"DDInter1825"
] | Omacetaxine mepesuccinate | Tofacitinib | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
4,
25,
976
]
],
[
[
4,
24,
200
],
[
200,
63,
976
]
],
[
[
4,
64,
998
],
[
998,
24,
976
]
],
[
[
4,
24,
1430
],
[
1430,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida alb... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Omacetaxine mepesuccinate may lead to a major life threatening interaction when take... |
DB11793 | DB15044 | 738 | 631 | [
"DDInter1297",
"DDInter1738"
] | Niraparib | Tafasitamab | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies. It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which has been modified with 2 amino acid substitutions to enhance its cytoto... | Moderate | 1 | [
[
[
738,
24,
631
]
],
[
[
738,
63,
4
],
[
4,
24,
631
]
],
[
[
738,
24,
270
],
[
270,
24,
631
]
],
[
[
738,
64,
976
],
[
976,
25,
... | [
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tafasitamab"
]
],
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
... | Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Tafasitamab
Niraparib may cause a moderate interaction that could exacerbate diseases when tak... |
DB00086 | DB10672 | 1,167 | 297 | [
"DDInter1712",
"DDInter417"
] | Streptokinase | Clove | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
1167,
23,
297
]
],
[
[
1167,
25,
235
],
[
235,
62,
297
]
],
[
[
1167,
24,
578
],
[
578,
23,
297
]
],
[
[
1167,
25,
1564
],
[
1564,
... | [
[
[
"Streptokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Streptokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
... | Streptokinase may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a m... |
DB00703 | DB00741 | 997 | 167 | [
"DDInter1167",
"DDInter885"
] | Methazolamide | Hydrocortisone | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
997,
24,
167
]
],
[
[
997,
24,
1220
],
[
1220,
40,
167
]
],
[
[
997,
63,
175
],
[
175,
40,
167
]
],
[
[
997,
63,
870
],
[
870,
1... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles ... |
DB01230 | DB01362 | 795 | 497 | [
"DDInter1416",
"DDInter960"
] | Pemoline | Iohexol | In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons. | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
795,
25,
497
]
],
[
[
795,
24,
1613
],
[
1613,
64,
497
]
],
[
[
795,
63,
372
],
[
372,
25,
497
]
],
[
[
795,
64,
593
],
[
593,
2... | [
[
[
"Pemoline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Pemoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
],
[
"Pegint... | Pemoline may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may lead to a major life threatening interaction when taken with Iohexol
Pemoline may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofa... |
DB00361 | DB06688 | 134 | 1,430 | [
"DDInter1939",
"DDInter1677"
] | Vinorelbine | Sipuleucel-T | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
134,
24,
1430
]
],
[
[
134,
24,
51
],
[
51,
24,
1430
]
],
[
[
134,
25,
676
],
[
676,
63,
1430
]
],
[
[
134,
24,
310
],
[
310,
63... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Vinorelbine may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitini... |
DB01390 | DB01416 | 1,117 | 1,024 | [
"DDInter1683",
"DDInter326"
] | Sodium bicarbonate | Cefpodoxime | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. | Moderate | 1 | [
[
[
1117,
24,
1024
]
],
[
[
1117,
63,
665
],
[
665,
40,
1024
]
],
[
[
1117,
63,
1462
],
[
1462,
1,
1024
]
],
[
[
1117,
21,
28642
],
[
2864... | [
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefpodoxime"
]
],
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime... | Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Cefpodoxime (Compound)
Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Cefpo... |
DB00294 | DB14724 | 1,336 | 48 | [
"DDInter701",
"DDInter634"
] | Etonogestrel | Emapalumab | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
1336,
24,
48
]
],
[
[
1336,
40,
1197
],
[
1197,
24,
48
]
],
[
[
1336,
63,
1031
],
[
1031,
24,
48
]
],
[
[
1336,
1,
873
],
[
873,
... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Etonogestrel",
"{u} (Compound) resembles {v} (Compound)",
"Norethisterone"
],
[
"Norethisterone",
"{u} may cau... | Etonogestrel (Compound) resembles Norethisterone (Compound) and Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate intera... |
DB00363 | DB09498 | 695 | 810 | [
"DDInter419",
"DDInter1715"
] | Clozapine | Strontium chloride Sr-89 | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Major | 2 | [
[
[
695,
25,
810
]
],
[
[
695,
64,
552
],
[
552,
24,
810
]
],
[
[
695,
25,
1555
],
[
1555,
24,
810
]
],
[
[
695,
25,
1480
],
[
1480,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carmustine"
],
[
"Carmustine",
... | Clozapine may lead to a major life threatening interaction when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Clozapine may lead to a major life threatening interaction when taken with Oxaliplatin and Oxaliplatin may cause a... |
DB01072 | DB09104 | 915 | 286 | [
"DDInter129",
"DDInter1118"
] | Atazanavir | Magnesium hydroxide | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
915,
24,
286
]
],
[
[
915,
64,
752
],
[
752,
23,
286
]
],
[
[
915,
25,
263
],
[
263,
23,
286
]
],
[
[
915,
25,
1593
],
[
1593,
2... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cimetidine"
],
[
"C... | Atazanavir may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Atazanavir may lead to a major life threatening interaction when taken with Axitinib and Axitinib may cause a minor inte... |
DB00277 | DB01068 | 1,031 | 1,565 | [
"DDInter1791",
"DDInter411"
] | Theophylline | Clonazepam | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Minor | 0 | [
[
[
1031,
23,
1565
]
],
[
[
1031,
23,
1382
],
[
1382,
1,
1565
]
],
[
[
1031,
23,
1216
],
[
1216,
40,
1565
]
],
[
[
1031,
62,
905
],
[
905,... | [
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clonazepam"
]
],
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Midazolam"
],
[
... | Theophylline may cause a minor interaction that can limit clinical effects when taken with Midazolam and Midazolam (Compound) resembles Clonazepam (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Flurazepam and Flurazepam (Compound) resembles Clonazepam (Compound)
Th... |
DB14004 | DB14783 | 398 | 287 | [
"DDInter1806",
"DDInter574"
] | Tildrakizumab | Diroximel fumarate | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis. The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psoriasi... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
398,
24,
287
]
],
[
[
398,
63,
599
],
[
599,
24,
287
]
],
[
[
398,
64,
1510
],
[
1510,
25,
287
]
],
[
[
398,
25,
676
],
[
676,
6... | [
[
[
"Tildrakizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Tildrakizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
... | Tildrakizumab may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Tildrakizumab may lead to a major life threatening interaction when taken with Teriflunomide and Te... |
DB00341 | DB00476 | 1,242 | 109 | [
"DDInter343",
"DDInter608"
] | Cetirizine | Duloxetine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
1242,
24,
109
]
],
[
[
1242,
24,
758
],
[
758,
1,
109
]
],
[
[
1242,
21,
29544
],
[
29544,
60,
109
]
],
[
[
1242,
24,
717
],
[
717,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) resembles Duloxetine (Compound)
Cetirizine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Duloxetine (Compound)
Cetirizine may cause a moderat... |
DB00501 | DB00564 | 752 | 1,236 | [
"DDInter380",
"DDInter293"
] | Cimetidine | Carbamazepine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
752,
24,
1236
]
],
[
[
752,
23,
307
],
[
307,
1,
1236
]
],
[
[
752,
64,
362
],
[
362,
1,
1236
]
],
[
[
752,
63,
1302
],
[
1302,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Carbamazepine (Compound)
Cimetidine may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Compound)
Cimetidine may ... |
DB00418 | DB14723 | 536 | 159 | [
"DDInter1650",
"DDInter1026"
] | Secobarbital | Larotrectinib | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
536,
24,
159
]
],
[
[
536,
24,
222
],
[
222,
23,
159
]
],
[
[
536,
24,
741
],
[
741,
24,
159
]
],
[
[
536,
62,
608
],
[
608,
24,... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and... |
DB10343 | DB12332 | 962 | 1,619 | [
"DDInter160",
"DDInter1626"
] | Bacillus calmette-guerin substrain tice live antigen | Rucaparib | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
962,
25,
1619
]
],
[
[
962,
64,
259
],
[
259,
24,
1619
]
],
[
[
962,
25,
1019
],
[
1019,
24,
1619
]
],
[
[
962,
63,
617
],
[
617,
... | [
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction whe... | Bacillus calmette-guerin substrain tice live antigen may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Bacillus calmette-guerin substrain tice live antigen may lead to a major life threaten... |
DB00023 | DB00108 | 305 | 1,066 | [
"DDInter127",
"DDInter1268"
] | Asparaginase Escherichia coli | Natalizumab | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Major | 2 | [
[
[
305,
25,
1066
]
],
[
[
305,
24,
949
],
[
949,
63,
1066
]
],
[
[
305,
25,
375
],
[
375,
64,
1066
]
],
[
[
305,
24,
738
],
[
738,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Natalizumab"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clo... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Nata... |
DB11248 | DB12035 | 1,193 | 943 | [
"DDInter1965",
"DDInter1641"
] | Zinc gluconate | Sarecycline | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA. It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wit... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1193,
24,
943
]
],
[
[
1193,
62,
1596
],
[
1596,
24,
943
]
],
[
[
1193,
23,
428
],
[
428,
63,
943
]
],
[
[
1193,
62,
1596
],
[
1596,
... | [
[
[
"Zinc gluconate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Zinc gluconate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Iron"
],
[
... | Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Iron and Iron may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate and Ferrous... |
DB00570 | DB12267 | 147 | 1,476 | [
"DDInter1936",
"DDInter233"
] | Vinblastine | Brigatinib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
147,
24,
1476
]
],
[
[
147,
63,
168
],
[
168,
23,
1476
]
],
[
[
147,
24,
629
],
[
629,
24,
1476
]
],
[
[
147,
63,
1184
],
[
1184,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolim... |
DB00560 | DB00855 | 753 | 213 | [
"DDInter1805",
"DDInter72"
] | Tigecycline | Aminolevulinic acid | Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S. Food and Drug Administration (FDA) on June 17,... | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Major | 2 | [
[
[
753,
25,
213
]
],
[
[
753,
40,
1572
],
[
1572,
25,
213
]
],
[
[
753,
63,
92
],
[
92,
25,
213
]
],
[
[
753,
64,
1101
],
[
1101,
2... | [
[
[
"Tigecycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aminolevulinic acid"
]
],
[
[
"Tigecycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocycline",
"{u} may lead to a m... | Tigecycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may lead to a major life threatening interaction when taken with Aminolevulinic acid
Tigecycline may cause a moderate interaction that could exacerbate diseases when taken with Methoxsalen and Methoxsalen may lead to a major life threatening ... |
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