drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00331 | DB00421 | 1,645 | 443 | [
"DDInter1164",
"DDInter1707"
] | Metformin | Spironolactone | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Moderate | 1 | [
[
[
1645,
24,
443
]
],
[
[
1645,
24,
167
],
[
167,
63,
443
]
],
[
[
1645,
24,
303
],
[
303,
40,
443
]
],
[
[
1645,
24,
989
],
[
989,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprog... |
DB08820 | DB08827 | 1,478 | 990 | [
"DDInter997",
"DDInter1085"
] | Ivacaftor | Lomitapide | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1478,
25,
990
]
],
[
[
1478,
64,
1080
],
[
1080,
1,
990
]
],
[
[
1478,
6,
8374
],
[
8374,
45,
990
]
],
[
[
1478,
54,
19133
],
[
19133,... | [
[
[
"Ivacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Ivacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",
"{u} (Co... | Ivacaftor may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Ivacaftor (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Ivacaftor (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class)... |
DB00562 | DB00747 | 1,014 | 1,442 | [
"DDInter188",
"DDInter1647"
] | Benzthiazide | Scopolamine | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Minor | 0 | [
[
[
1014,
23,
1442
]
],
[
[
1014,
62,
19
],
[
19,
24,
1442
]
],
[
[
1014,
1,
811
],
[
811,
23,
1442
]
],
[
[
1014,
40,
504
],
[
504,
... | [
[
[
"Benzthiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Scopolamine"
]
],
[
[
"Benzthiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyoscyamine"
],
[
... | Benzthiazide may cause a minor interaction that can limit clinical effects when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Benzthiazide (Compound) resembles Metolazone (Compound) and Metolazone may cause a minor interaction that can... |
DB00008 | DB15965 | 491 | 1,330 | [
"DDInter1407",
"DDInter1270"
] | Peginterferon alfa-2a | Naxitamab | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
491,
24,
1330
]
],
[
[
491,
24,
14
],
[
14,
24,
1330
]
],
[
[
491,
23,
450
],
[
450,
24,
1330
]
],
[
[
491,
24,
375
],
[
375,
25... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuva... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Peginterferon alfa-2a may cause a minor interaction that can limit clinical effects when taken wit... |
DB00880 | DB04843 | 359 | 1,511 | [
"DDInter360",
"DDInter1149"
] | Chlorothiazide | Mepenzolate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Minor | 0 | [
[
[
359,
23,
1511
]
],
[
[
359,
23,
1192
],
[
1192,
24,
1511
]
],
[
[
359,
62,
262
],
[
262,
24,
1511
]
],
[
[
359,
21,
28898
],
[
28898,
... | [
[
[
"Chlorothiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mepenzolate"
]
],
[
[
"Chlorothiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Glycopyrronium"
],... | Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Clidiniu... |
DB00377 | DB04844 | 1,494 | 843 | [
"DDInter1382",
"DDInter1778"
] | Palonosetron | Tetrabenazine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
1494,
24,
843
]
],
[
[
1494,
24,
479
],
[
479,
40,
843
]
],
[
[
1494,
6,
12523
],
[
12523,
45,
843
]
],
[
[
1494,
21,
28698
],
[
28698... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Palonosetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tetrabenazine (Compound)
Palonosetron (Compound) causes Insomnia (Side Effect) and ... |
DB00374 | DB14357 | 1,061 | 944 | [
"DDInter1852",
"DDInter347"
] | Treprostinil | Chamomile | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
1061,
23,
944
]
],
[
[
1061,
24,
256
],
[
256,
23,
944
]
],
[
[
1061,
63,
582
],
[
582,
23,
944
]
],
[
[
1061,
25,
792
],
[
792,
... | [
[
[
"Treprostinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
],
[
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Reteplase and Reteplas... |
DB00982 | DB15093 | 1,517 | 1,654 | [
"DDInter991",
"DDInter1698"
] | Isotretinoin | Somapacitan | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1517,
24,
1654
]
],
[
[
1517,
63,
167
],
[
167,
24,
1654
]
],
[
[
1517,
24,
868
],
[
868,
24,
1654
]
],
[
[
1517,
64,
1101
],
[
1101,
... | [
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],... | Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafe... |
DB00843 | DB06595 | 479 | 1,491 | [
"DDInter583",
"DDInter1214"
] | Donepezil | Midostaurin | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
479,
24,
1491
]
],
[
[
479,
24,
112
],
[
112,
23,
1491
]
],
[
[
479,
63,
888
],
[
888,
24,
1491
]
],
[
[
479,
24,
1017
],
[
1017,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamo... |
DB08868 | DB14409 | 1,011 | 1,129 | [
"DDInter737",
"DDInter867"
] | Fingolimod | Human adenovirus e serotype 4 strain cl-68578 antigen | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1011,
24,
1129
]
],
[
[
1011,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1011,
25,
1456
],
[
1456,
24,
1129
]
],
[
[
1011,
25,
676
],
[
676... | [
[
[
"Fingolimod",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Fingolimod may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Fingolimod may lead to a major life threatening interaction when taken with Venetocl... |
DB00087 | DB00099 | 599 | 440 | [
"DDInter41",
"DDInter735"
] | Alemtuzumab | Filgrastim | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Moderate | 1 | [
[
[
599,
24,
440
]
],
[
[
599,
24,
37
],
[
37,
63,
440
]
],
[
[
599,
63,
1451
],
[
1451,
24,
440
]
],
[
[
599,
25,
1064
],
[
1064,
6... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Filgrastim"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfa-n1 an... |
DB00996 | DB09104 | 1,198 | 286 | [
"DDInter791",
"DDInter1118"
] | Gabapentin | Magnesium hydroxide | Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to tr... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
1198,
23,
286
]
],
[
[
1198,
24,
820
],
[
820,
23,
286
]
],
[
[
1198,
62,
752
],
[
752,
23,
286
]
],
[
[
1198,
24,
1487
],
[
1487,
... | [
[
[
"Gabapentin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Gabapentin may cause a minor interaction that can limit clinical effects when taken with Cimetidine and... |
DB09118 | DB11718 | 1,580 | 927 | [
"DDInter1711",
"DDInter640"
] | Stiripentol | Encorafenib | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
1580,
25,
927
]
],
[
[
1580,
63,
1324
],
[
1324,
24,
927
]
],
[
[
1580,
25,
484
],
[
484,
63,
927
]
],
[
[
1580,
24,
564
],
[
564,
... | [
[
[
"Stiripentol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
"Trogl... | Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Stiripentol may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib m... |
DB00554 | DB06228 | 1,027 | 792 | [
"DDInter1478",
"DDInter1609"
] | Piroxicam | Rivaroxaban | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
1027,
25,
792
]
],
[
[
1027,
62,
752
],
[
752,
24,
792
]
],
[
[
1027,
24,
738
],
[
738,
63,
792
]
],
[
[
1027,
24,
1220
],
[
1220,
... | [
[
[
"Piroxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Piroxicam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
],
[
"Cimetidine",
... | Piroxicam may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib ... |
DB00601 | DB00912 | 453 | 473 | [
"DDInter1073",
"DDInter1581"
] | Linezolid | Repaglinide | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
453,
24,
473
]
],
[
[
453,
21,
28873
],
[
28873,
60,
473
]
],
[
[
453,
64,
73
],
[
73,
24,
473
]
],
[
[
453,
24,
1148
],
[
1148,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Linezolid",
"{u} (Compound) causes {v} (Side Effect)",
"Pancreatitis"
],
[
"Pancreatitis",
"{u} (Side Effect) is... | Linezolid (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Repaglinide (Compound)
Linezolid may lead to a major life threatening interaction when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Lin... |
DB11714 | DB14409 | 1,316 | 1,129 | [
"DDInter610",
"DDInter867"
] | Durvalumab | Human adenovirus e serotype 4 strain cl-68578 antigen | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1316,
24,
1129
]
],
[
[
1316,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1316,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
1316,
25,
1259
],
[
12... | [
[
[
"Durvalumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Durvalumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Durvalumab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Durvalumab may cause a moderate interaction that could exacerbate diseases when take... |
DB00668 | DB00850 | 874 | 1,630 | [
"DDInter652",
"DDInter1432"
] | Epinephrine | Perphenazine | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
874,
24,
1630
]
],
[
[
874,
63,
508
],
[
508,
40,
1630
]
],
[
[
874,
24,
673
],
[
673,
40,
1630
]
],
[
[
874,
25,
1237
],
[
1237,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Perphenazine (Compound)
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole (Compound) resembles Perphenazine (Co... |
DB00745 | DB00990 | 307 | 1,547 | [
"DDInter1236",
"DDInter705"
] | Modafinil | Exemestane | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Moderate | 1 | [
[
[
307,
24,
1547
]
],
[
[
307,
23,
891
],
[
891,
40,
1547
]
],
[
[
307,
62,
1573
],
[
1573,
40,
1547
]
],
[
[
307,
6,
8374
],
[
8374,
... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exemestane"
]
],
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisolone"
],
[
... | Modafinil may cause a minor interaction that can limit clinical effects when taken with Prednisolone and Prednisolone (Compound) resembles Exemestane (Compound)
Modafinil may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone (Compound) resembles Exemestane (Compound)
Mo... |
DB01041 | DB08895 | 770 | 976 | [
"DDInter1789",
"DDInter1825"
] | Thalidomide | Tofacitinib | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
770,
25,
976
]
],
[
[
770,
24,
982
],
[
982,
63,
976
]
],
[
[
770,
63,
1020
],
[
1020,
24,
976
]
],
[
[
770,
24,
1482
],
[
1482,
... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
],
[
"Ivoside... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clon... |
DB00031 | DB04896 | 20 | 901 | [
"DDInter1764",
"DDInter1220"
] | Tenecteplase | Milnacipran | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
20,
24,
901
]
],
[
[
20,
24,
41
],
[
41,
1,
901
]
],
[
[
20,
25,
405
],
[
405,
63,
901
]
],
[
[
20,
25,
500
],
[
500,
24,
... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]... | Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Tenecteplase may lead to a major life threatening interaction when taken with Acalabrutinib and Acalabrutinib may cause a moderate interaction that... |
DB13928 | DB15093 | 1,385 | 1,654 | [
"DDInter1660",
"DDInter1698"
] | Semaglutide | Somapacitan | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1385,
24,
1654
]
],
[
[
1385,
63,
168
],
[
168,
23,
1654
]
],
[
[
1385,
63,
176
],
[
176,
24,
1654
]
],
[
[
1385,
64,
1101
],
[
1101,
... | [
[
[
"Semaglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Semaglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Semaglutide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Semaglutide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and... |
DB00047 | DB00222 | 176 | 245 | [
"DDInter932",
"DDInter825"
] | Insulin glargine | Glimepiride | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Moderate | 1 | [
[
[
176,
24,
245
]
],
[
[
176,
24,
959
],
[
959,
1,
245
]
],
[
[
176,
23,
721
],
[
721,
62,
245
]
],
[
[
176,
23,
333
],
[
333,
23,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Glimepiride (Compound)
Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Methylcellulose and Methylcellulose may cause a minor intera... |
DB00188 | DB11952 | 168 | 800 | [
"DDInter222",
"DDInter612"
] | Bortezomib | Duvelisib | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
168,
24,
800
]
],
[
[
168,
24,
310
],
[
310,
24,
800
]
],
[
[
168,
23,
1476
],
[
1476,
63,
800
]
],
[
[
168,
63,
440
],
[
440,
2... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib and Brigati... |
DB01281 | DB10316 | 881 | 334 | [
"DDInter5",
"DDInter1248"
] | Abatacept | Mumps virus strain B level jeryl lynn live antigen | Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS mo... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
881,
25,
334
]
],
[
[
881,
64,
1057
],
[
1057,
25,
334
]
],
[
[
881,
25,
908
],
[
908,
25,
334
]
],
[
[
881,
63,
599
],
[
599,
2... | [
[
[
"Abatacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Abatacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
],
... | Abatacept may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Abatacept may lead to a major life threatening interaction when taken with Golimumab and Golimumab may ... |
DB00404 | DB06674 | 523 | 908 | [
"DDInter54",
"DDInter837"
] | Alprazolam | Golimumab | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
523,
24,
908
]
],
[
[
523,
40,
1382
],
[
1382,
24,
908
]
],
[
[
523,
63,
608
],
[
608,
24,
908
]
],
[
[
523,
62,
1031
],
[
1031,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Alprazolam",
"{u} (Compound) resembles {v} (Compound)",
"Midazolam"
],
[
"Midazolam",
"{u} may cause a moderate i... | Alprazolam (Compound) resembles Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exac... |
DB00857 | DB01036 | 1,387 | 211 | [
"DDInter1768",
"DDInter1832"
] | Terbinafine | Tolterodine | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Minor | 0 | [
[
[
1387,
23,
211
]
],
[
[
1387,
24,
573
],
[
573,
40,
211
]
],
[
[
1387,
63,
1523
],
[
1523,
40,
211
]
],
[
[
1387,
6,
10215
],
[
10215,
... | [
[
[
"Terbinafine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolterodine"
]
],
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
],
[... | Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Fesoterodine and Fesoterodine (Compound) resembles Tolterodine (Compound)
Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Tolterodine (Comp... |
DB00486 | DB00647 | 1,614 | 675 | [
"DDInter1253",
"DDInter528"
] | Nabilone | Dextropropoxyphene | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Major | 2 | [
[
[
1614,
25,
675
]
],
[
[
1614,
24,
649
],
[
649,
1,
675
]
],
[
[
1614,
25,
1301
],
[
1301,
40,
675
]
],
[
[
1614,
24,
954
],
[
954,
... | [
[
[
"Nabilone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
"Clofed... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Dextropropoxyphene (Compound)
Nabilone may lead to a major life threatening interaction when taken with Levacetylmethadol and Levacetylmethadol (Compound) resembles Dextropropoxyphene ... |
DB01023 | DB06674 | 409 | 908 | [
"DDInter716",
"DDInter837"
] | Felodipine | Golimumab | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
409,
24,
908
]
],
[
[
409,
1,
336
],
[
336,
24,
908
]
],
[
[
409,
40,
84
],
[
84,
24,
908
]
],
[
[
409,
62,
1031
],
[
1031,
24,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Felodipine",
"{u} (Compound) resembles {v} (Compound)",
"Nifedipine"
],
[
"Nifedipine",
"{u} may cause a moderate... | Felodipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Felodipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
... |
DB08816 | DB15982 | 578 | 1,339 | [
"DDInter1802",
"DDInter193"
] | Ticagrelor | Berotralstat | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
578,
24,
1339
]
],
[
[
578,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
578,
24,
283
],
[
283,
23,
1339
]
],
[
[
578,
63,
761
],
[
761,
... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB00902 | DB06207 | 104 | 910 | [
"DDInter1168",
"DDInter1667"
] | Methdilazine | Silodosin | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Moderate | 1 | [
[
[
104,
24,
910
]
],
[
[
104,
24,
1264
],
[
1264,
24,
910
]
],
[
[
104,
24,
1450
],
[
1450,
63,
910
]
],
[
[
104,
63,
530
],
[
530,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Silodosin"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Silodosin
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagl... |
DB00556 | DB05294 | 1,262 | 1,069 | [
"DDInter1429",
"DDInter1917"
] | Perflutren | Vandetanib | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1262,
25,
1069
]
],
[
[
1262,
21,
28719
],
[
28719,
60,
1069
]
],
[
[
1262,
23,
112
],
[
112,
23,
1069
]
],
[
[
1262,
24,
659
],
[
659... | [
[
[
"Perflutren",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Perflutren",
"{u} (Compound) causes {v} (Side Effect)",
"Pain"
],
[
"Pain",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Perflutren (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vandetanib (Compound)
Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vandetanib
Perf... |
DB00252 | DB06282 | 362 | 516 | [
"DDInter1460",
"DDInter1053"
] | Phenytoin | Levocetirizine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
362,
24,
516
]
],
[
[
362,
24,
1031
],
[
1031,
23,
516
]
],
[
[
362,
24,
701
],
[
701,
24,
516
]
],
[
[
362,
1,
697
],
[
697,
24... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
],
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Levocetirizine
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Cl... |
DB00348 | DB01149 | 254 | 851 | [
"DDInter1300",
"DDInter1274"
] | Nitisinone | Nefazodone | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
254,
24,
851
]
],
[
[
254,
21,
28762
],
[
28762,
60,
851
]
],
[
[
254,
63,
1101
],
[
1101,
23,
851
]
],
[
[
254,
24,
1374
],
[
1374,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused... | Nitisinone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nefazodone (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Nefazodone
... |
DB00395 | DB00692 | 210 | 274 | [
"DDInter301",
"DDInter1448"
] | Carisoprodol | Phentolamine | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with b... | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
210,
24,
274
]
],
[
[
210,
21,
29118
],
[
29118,
60,
274
]
],
[
[
210,
24,
530
],
[
530,
24,
274
]
],
[
[
210,
24,
104
],
[
104,
... | [
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Carisoprodol",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effec... | Carisoprodol (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00370 | DB00445 | 1,251 | 322 | [
"DDInter1230",
"DDInter655"
] | Mirtazapine | Epirubicin | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
1251,
24,
322
]
],
[
[
1251,
18,
10699
],
[
10699,
57,
322
]
],
[
[
1251,
21,
30357
],
[
30357,
60,
322
]
],
[
[
1251,
23,
112
],
[
11... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Mirtazapine",
"{u} (Compound) downregulates {v} (Gene)",
"KIF20A"
],
[
"KIF20A",
"{u} (Gene) is downregulated b... | Mirtazapine (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Epirubicin (Compound)
Mirtazapine (Compound) causes Aphthous stomatitis (Side Effect) and Aphthous stomatitis (Side Effect) is caused by Epirubicin (Compound)
Mirtazapine may cause a minor interaction that can limit clinical effect... |
DB00696 | DB04868 | 826 | 478 | [
"DDInter665",
"DDInter1293"
] | Ergotamine | Nilotinib | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
826,
24,
478
]
],
[
[
826,
6,
4973
],
[
4973,
45,
478
]
],
[
[
826,
21,
28719
],
[
28719,
60,
478
]
],
[
[
826,
24,
1040
],
[
1040,
... | [
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Ergotamine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Ergotamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Ergotamine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Nilotinib (Compound)
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cau... |
DB00810 | DB11186 | 456 | 1,609 | [
"DDInter211",
"DDInter1427"
] | Biperiden | Pentoxyverine | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
456,
24,
1609
]
],
[
[
456,
24,
104
],
[
104,
24,
1609
]
],
[
[
456,
63,
999
],
[
999,
24,
1609
]
],
[
[
456,
1,
1386
],
[
1386,
... | [
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine... |
DB00723 | DB01168 | 1,240 | 1,053 | [
"DDInter1176",
"DDInter1526"
] | Methoxamine | Procarbazine | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1240,
24,
1053
]
],
[
[
1240,
24,
480
],
[
480,
24,
1053
]
],
[
[
1240,
24,
659
],
[
659,
63,
1053
]
],
[
[
1240,
1,
1290
],
[
1290,
... | [
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine
Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vi... |
DB00405 | DB00748 | 128 | 662 | [
"DDInter517",
"DDInter297"
] | Dexbrompheniramine | Carbinoxamine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
128,
24,
662
]
],
[
[
128,
40,
28
],
[
28,
40,
662
]
],
[
[
128,
1,
11786
],
[
11786,
40,
662
]
],
[
[
128,
74,
1594
],
[
1594,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Dexbrompheniramine",
"{u} (Compound) resembles {v} (Compound)",
"Bisacodyl"
],
[
"Bisacodyl",
"{u} (C... | Dexbrompheniramine (Compound) resembles Bisacodyl (Compound) and Bisacodyl (Compound) resembles Carbinoxamine (Compound)
Dexbrompheniramine (Compound) resembles Captodiame (Compound) and Captodiame (Compound) resembles Carbinoxamine (Compound)
Dexbrompheniramine (Compound) resembles Doxylamine (Compound) and Dexbromphe... |
DB08885 | DB10315 | 363 | 1,137 | [
"DDInter33",
"DDInter1127"
] | Aflibercept | Measles virus vaccine live attenuated | Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Dalt... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
363,
25,
1137
]
],
[
[
363,
64,
581
],
[
581,
25,
1137
]
],
[
[
363,
24,
384
],
[
384,
25,
1137
]
],
[
[
363,
63,
1184
],
[
1184,
... | [
[
[
"Aflibercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Aflibercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Aflibercept may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Aflibercept may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelali... |
DB00363 | DB11113 | 695 | 657 | [
"DDInter419",
"DDInter307"
] | Clozapine | Castor oil | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
695,
24,
657
]
],
[
[
695,
25,
927
],
[
927,
63,
657
]
],
[
[
695,
25,
1491
],
[
1491,
24,
657
]
],
[
[
695,
64,
1181
],
[
1181,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafenib... | Clozapine may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Clozapine may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderate in... |
DB00685 | DB00762 | 1,299 | 613 | [
"DDInter1887",
"DDInter973"
] | Trovafloxacin | Irinotecan | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Minor | 0 | [
[
[
1299,
23,
613
]
],
[
[
1299,
23,
869
],
[
869,
63,
613
]
],
[
[
1299,
6,
3199
],
[
3199,
57,
613
]
],
[
[
1299,
21,
28675
],
[
28675,
... | [
[
[
"Trovafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Irinotecan"
]
],
[
[
"Trovafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Topotecan"
],
[
... | Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Irinotecan (Compound)
Trovafloxa... |
DB00747 | DB00934 | 1,442 | 413 | [
"DDInter1647",
"DDInter1124"
] | Scopolamine | Maprotiline | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
1442,
24,
413
]
],
[
[
1442,
63,
1302
],
[
1302,
40,
413
]
],
[
[
1442,
6,
4973
],
[
4973,
45,
413
]
],
[
[
1442,
21,
28741
],
[
28741... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Scopolamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Maprotiline (Compound)
Scopolamine (Compound) causes Agitation (Side Effect) and ... |
DB00476 | DB08870 | 109 | 850 | [
"DDInter608",
"DDInter228"
] | Duloxetine | Brentuximab vedotin | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
109,
24,
850
]
],
[
[
109,
24,
267
],
[
267,
24,
850
]
],
[
[
109,
40,
847
],
[
847,
24,
850
]
],
[
[
109,
63,
883
],
[
883,
24,... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Duloxetine (Compound) resembles Atomoxetine (Compound) and Atomoxetine may cause a moderate interaction... |
DB00191 | DB01365 | 73 | 280 | [
"DDInter1447",
"DDInter1151"
] | Phentermine | Mephentermine | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Moderate | 1 | [
[
[
73,
35,
280
]
],
[
[
73,
1,
11357
],
[
11357,
1,
280
]
],
[
[
73,
25,
551
],
[
551,
1,
280
]
],
[
[
73,
1,
80
],
[
80,
40,
... | [
[
[
"Phentermine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephentermine"
]
],
[
[
"Phentermine",
"{u} (Compound) resembles {v} (Compound)",
"Phenformin"
],
[
... | Phentermine (Compound) resembles Mephentermine (Compound) and
Phentermine (Compound) resembles Phenformin (Compound) and Phenformin (Compound) resembles Mephentermine (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Mephentermine (Com... |
DB00290 | DB09498 | 329 | 810 | [
"DDInter219",
"DDInter1715"
] | Bleomycin | Strontium chloride Sr-89 | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
329,
24,
810
]
],
[
[
329,
63,
552
],
[
552,
24,
810
]
],
[
[
329,
24,
1555
],
[
1555,
24,
810
]
],
[
[
329,
24,
385
],
[
385,
6... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplat... |
DB00331 | DB00939 | 1,645 | 1,338 | [
"DDInter1164",
"DDInter1135"
] | Metformin | Meclofenamic acid | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
1645,
24,
1338
]
],
[
[
1645,
21,
28900
],
[
28900,
60,
1338
]
],
[
[
1645,
24,
1194
],
[
1194,
23,
1338
]
],
[
[
1645,
24,
1573
],
[
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Metformin",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side ... | Metformin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Meclofenamic acid (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken... |
DB00531 | DB00827 | 450 | 646 | [
"DDInter456",
"DDInter383"
] | Cyclophosphamide | Cinoxacin | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Minor | 0 | [
[
[
450,
23,
646
]
],
[
[
450,
21,
28722
],
[
28722,
60,
646
]
],
[
[
450,
24,
77
],
[
77,
62,
646
]
],
[
[
450,
63,
329
],
[
329,
2... | [
[
[
"Cyclophosphamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cinoxacin"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is c... | Cyclophosphamide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Cinoxacin (Compound)
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Cino... |
DB00431 | DB00780 | 1,503 | 551 | [
"DDInter1072",
"DDInter1440"
] | Lindane | Phenelzine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Moderate | 1 | [
[
[
1503,
24,
551
]
],
[
[
1503,
24,
633
],
[
633,
40,
551
]
],
[
[
1503,
63,
73
],
[
73,
25,
551
]
],
[
[
1503,
63,
80
],
[
80,
40,... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Lisdexamfetamine and Lisdexamfetamine (Compound) resembles Phenelzine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may lead to a major life threatenin... |
DB01242 | DB11837 | 1,237 | 1,297 | [
"DDInter410",
"DDInter1351"
] | Clomipramine | Osilodrostat | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1237,
24,
1297
]
],
[
[
1237,
62,
112
],
[
112,
23,
1297
]
],
[
[
1237,
64,
222
],
[
222,
23,
1297
]
],
[
[
1237,
24,
578
],
[
578,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Clomipramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Clomipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Clomipramine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine ... |
DB00804 | DB08897 | 1,507 | 1,429 | [
"DDInter543",
"DDInter22"
] | Dicyclomine | Aclidinium | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
1507,
24,
1429
]
],
[
[
1507,
63,
352
],
[
352,
24,
1429
]
],
[
[
1507,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
1507,
6,
4304
],
[
4304,... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzo... |
DB05676 | DB11979 | 1,513 | 1,320 | [
"DDInter111",
"DDInter625"
] | Apremilast | Elagolix | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1513,
24,
1320
]
],
[
[
1513,
63,
1249
],
[
1249,
24,
1320
]
],
[
[
1513,
25,
129
],
[
129,
24,
1320
]
],
[
[
1513,
24,
1155
],
[
1155... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Apremilast may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause ... |
DB00563 | DB01611 | 663 | 1,487 | [
"DDInter1174",
"DDInter893"
] | Methotrexate | Hydroxychloroquine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Minor | 0 | [
[
[
663,
23,
1487
]
],
[
[
663,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
663,
24,
1247
],
[
1247,
23,
1487
]
],
[
[
663,
63,
168
],
[
168,
... | [
[
[
"Methotrexate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Methotrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect)... | Methotrexate (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects whe... |
DB00317 | DB00607 | 883 | 1,249 | [
"DDInter810",
"DDInter1256"
] | Gefitinib | Nafcillin | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Moderate | 1 | [
[
[
883,
24,
1249
]
],
[
[
883,
6,
8374
],
[
8374,
45,
1249
]
],
[
[
883,
7,
3422
],
[
3422,
46,
1249
]
],
[
[
883,
18,
4360
],
[
4360,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
]
],
[
[
"Gefitinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Gefitinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nafcillin (Compound)
Gefitinib (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Nafcillin (Compound)
Gefitinib (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Nafcillin (Compound)
Gefitinib (Compound)... |
DB08930 | DB09065 | 1,459 | 760 | [
"DDInter582",
"DDInter424"
] | Dolutegravir | Cobicistat | Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and ... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Minor | 0 | [
[
[
1459,
23,
760
]
],
[
[
1459,
62,
1101
],
[
1101,
23,
760
]
],
[
[
1459,
62,
723
],
[
723,
24,
760
]
],
[
[
1459,
23,
98
],
[
98,
... | [
[
[
"Dolutegravir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cobicistat"
]
],
[
[
"Dolutegravir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Dolutegravir may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Dolutegravir may cause a minor interaction that can limit clinical effects when taken with Aprepitant and Aprepita... |
DB00379 | DB09039 | 143 | 1,670 | [
"DDInter1206",
"DDInter629"
] | Mexiletine | Eliglustat | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
143,
24,
1670
]
],
[
[
143,
24,
187
],
[
187,
24,
1670
]
],
[
[
143,
24,
1045
],
[
1045,
64,
1670
]
],
[
[
143,
24,
1374
],
[
1374,
... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
],
[
... | Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone and Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib and Dac... |
DB00981 | DB01010 | 1,528 | 61 | [
"DDInter1462",
"DDInter622"
] | Physostigmine | Edrophonium | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Moderate | 1 | [
[
[
1528,
24,
61
]
],
[
[
1528,
24,
1372
],
[
1372,
63,
61
]
],
[
[
1528,
6,
10558
],
[
10558,
45,
61
]
],
[
[
1528,
21,
28658
],
[
28658,... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edrophonium"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neostigmine"
],
... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Neostigmine and Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium
Physostigmine (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Edrophonium (Compound)
Physostigmin... |
DB00420 | DB00992 | 508 | 842 | [
"DDInter1532",
"DDInter1182"
] | Promazine | Methyl aminolevulinate (topical) | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Moderate | 1 | [
[
[
508,
24,
842
]
],
[
[
508,
1,
820
],
[
820,
63,
842
]
],
[
[
508,
40,
1178
],
[
1178,
24,
842
]
],
[
[
508,
24,
392
],
[
392,
63... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl aminolevulinate"
]
],
[
[
"Promazine",
"{u} (Compound) resembles {v} (Compound)",
"Alimemazine"
],
[
"Alimemazine",
"{u} may cau... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Promazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Promazine (Compound) resembles Tri... |
DB00222 | DB11921 | 245 | 1,019 | [
"DDInter825",
"DDInter492"
] | Glimepiride | Deflazacort | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
245,
24,
1019
]
],
[
[
245,
24,
1072
],
[
1072,
23,
1019
]
],
[
[
245,
24,
192
],
[
192,
24,
1019
]
],
[
[
245,
40,
959
],
[
959,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens a... |
DB00420 | DB12332 | 508 | 1,619 | [
"DDInter1532",
"DDInter1626"
] | Promazine | Rucaparib | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
508,
24,
1619
]
],
[
[
508,
24,
222
],
[
222,
23,
1619
]
],
[
[
508,
23,
112
],
[
112,
23,
1619
]
],
[
[
508,
24,
1662
],
[
1662,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Promazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronid... |
DB00072 | DB06372 | 550 | 259 | [
"DDInter1846",
"DDInter1594"
] | Trastuzumab | Rilonacept | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
550,
24,
259
]
],
[
[
550,
24,
1367
],
[
1367,
63,
259
]
],
[
[
550,
24,
4
],
[
4,
24,
259
]
],
[
[
550,
25,
770
],
[
770,
24,
... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Reco... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant) and Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Trastuzumab may cause a moderate interaction that could exacerbat... |
DB00945 | DB09472 | 1,479 | 1,383 | [
"DDInter20",
"DDInter1693"
] | Acetylsalicylic acid | Sodium sulfate | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1479,
24,
1383
]
],
[
[
1479,
63,
1252
],
[
1252,
23,
1383
]
],
[
[
1479,
24,
643
],
[
643,
24,
1383
]
],
[
[
1479,
23,
1311
],
[
1311... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dig... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Sodium sulfate
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Desve... |
DB01018 | DB06589 | 1,364 | 1,250 | [
"DDInter847",
"DDInter1400"
] | Guanfacine | Pazopanib | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1364,
24,
1250
]
],
[
[
1364,
6,
8374
],
[
8374,
45,
1250
]
],
[
[
1364,
21,
28658
],
[
28658,
60,
1250
]
],
[
[
1364,
64,
1419
],
[
1... | [
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Guanfacine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Guanfacine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pazopanib (Compound)
Guanfacine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Guanfacine may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a mode... |
DB00643 | DB09420 | 1,370 | 1,074 | [
"DDInter1128",
"DDInter953"
] | Mebendazole | Iodide I-123 | A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem] | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1370,
24,
1074
]
],
[
[
1370,
40,
510
],
[
510,
24,
1074
]
],
[
[
1370,
24,
112
],
[
112,
24,
1074
]
],
[
[
1370,
40,
510
],
[
510,
... | [
[
[
"Mebendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Mebendazole",
"{u} (Compound) resembles {v} (Compound)",
"Albendazole"
],
[
"Albendazole",
"{u} may cause a m... | Mebendazole (Compound) resembles Albendazole (Compound) and Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Mebendazole may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a moderate interactio... |
DB00030 | DB06710 | 1,685 | 1,546 | [
"DDInter934",
"DDInter1193"
] | Insulin human | Methyltestosterone | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
1685,
24,
1546
]
],
[
[
1685,
24,
155
],
[
155,
1,
1546
]
],
[
[
1685,
24,
984
],
[
984,
40,
1546
]
],
[
[
1685,
24,
1486
],
[
1486,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymestero... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Methyltestosterone (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Meth... |
DB00041 | DB00515 | 1,648 | 589 | [
"DDInter38",
"DDInter387"
] | Aldesleukin | Cisplatin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Major | 2 | [
[
[
1648,
25,
589
]
],
[
[
1648,
23,
956
],
[
956,
62,
589
]
],
[
[
1648,
23,
839
],
[
839,
23,
589
]
],
[
[
1648,
24,
949
],
[
949,
... | [
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Norfloxacin"
],
[
"Norfloxaci... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Cisplatin
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin and Grepaf... |
DB06791 | DB09237 | 1,446 | 1,586 | [
"DDInter1021",
"DDInter1045"
] | Lanreotide | Levamlodipine | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
1446,
24,
1586
]
],
[
[
1446,
23,
466
],
[
466,
62,
1586
]
],
[
[
1446,
63,
549
],
[
549,
24,
1586
]
],
[
[
1446,
24,
124
],
[
124,
... | [
[
[
"Lanreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Lanreotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[... | Lanreotide may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Lanreotide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and ... |
DB01253 | DB01254 | 628 | 1,213 | [
"DDInter664",
"DDInter484"
] | Ergometrine | Dasatinib | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
628,
24,
1213
]
],
[
[
628,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
628,
7,
7638
],
[
7638,
46,
1213
]
],
[
[
628,
21,
28956
],
[
28956,
... | [
[
[
"Ergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Ergometrine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Ergometrine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Ergometrine (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is upregulated by Dasatinib (Compound)
Ergometrine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dasatinib (Compound... |
DB00514 | DB00850 | 506 | 1,630 | [
"DDInter527",
"DDInter1432"
] | Dextromethorphan | Perphenazine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
506,
24,
1630
]
],
[
[
506,
24,
252
],
[
252,
40,
1630
]
],
[
[
506,
25,
827
],
[
827,
40,
1630
]
],
[
[
506,
63,
508
],
[
508,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Dextromethorphan may lead to a major life threatening interaction when taken with Trazodone and Trazodone (Compound) resembles Perphenazine (Compound)... |
DB00078 | DB00095 | 1,172 | 66 | [
"DDInter898",
"DDInter623"
] | Ibritumomab tiuxetan | Efalizumab | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Moderate | 1 | [
[
[
1172,
24,
66
]
],
[
[
1172,
24,
151
],
[
151,
63,
66
]
],
[
[
1172,
25,
4
],
[
4,
63,
66
]
],
[
[
1172,
64,
581
],
[
581,
24,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influen... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) and Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) may cause a moderate interaction that could... |
DB00619 | DB01227 | 1,419 | 1,301 | [
"DDInter909",
"DDInter1043"
] | Imatinib | Levacetylmethadol | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Major | 2 | [
[
[
1419,
25,
1301
]
],
[
[
1419,
63,
494
],
[
494,
1,
1301
]
],
[
[
1419,
23,
307
],
[
307,
1,
1301
]
],
[
[
1419,
24,
146
],
[
146,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],
[
"Disop... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Imatinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Levacetylmethadol (... |
DB00692 | DB00844 | 274 | 314 | [
"DDInter1448",
"DDInter1257"
] | Phentolamine | Nalbuphine | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Moderate | 1 | [
[
[
274,
24,
314
]
],
[
[
274,
63,
828
],
[
828,
40,
314
]
],
[
[
274,
63,
421
],
[
421,
1,
314
]
],
[
[
274,
63,
475
],
[
475,
25,
... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Nalbuphine (Co... |
DB00912 | DB09389 | 473 | 517 | [
"DDInter1581",
"DDInter1315"
] | Repaglinide | Norgestrel | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
473,
24,
517
]
],
[
[
473,
24,
1130
],
[
1130,
23,
517
]
],
[
[
473,
24,
52
],
[
52,
24,
517
]
],
[
[
473,
24,
159
],
[
159,
63,... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and D... |
DB00261 | DB00475 | 702 | 1,119 | [
"DDInter93",
"DDInter355"
] | Anagrelide | Chlordiazepoxide | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Moderate | 1 | [
[
[
702,
24,
1119
]
],
[
[
702,
25,
87
],
[
87,
40,
1119
]
],
[
[
702,
24,
1274
],
[
1274,
40,
1119
]
],
[
[
702,
24,
286
],
[
286,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlordiazepoxide"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amoxapine"
],
[
"Amoxa... | Anagrelide may lead to a major life threatening interaction when taken with Amoxapine and Amoxapine (Compound) resembles Chlordiazepoxide (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Chlordiazepoxide (Compound)
A... |
DB00598 | DB00757 | 1,523 | 1,166 | [
"DDInter1013",
"DDInter581"
] | Labetalol | Dolasetron | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1523,
25,
1166
]
],
[
[
1523,
63,
19
],
[
19,
40,
1166
]
],
[
[
1523,
63,
85
],
[
85,
1,
1166
]
],
[
[
1523,
6,
12523
],
[
12523,
... | [
[
[
"Labetalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyamine... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Dolasetron (Compound)
Labe... |
DB00927 | DB04953 | 1,559 | 495 | [
"DDInter712",
"DDInter708"
] | Famotidine | Ezogabine | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
1559,
24,
495
]
],
[
[
1559,
21,
28787
],
[
28787,
60,
495
]
],
[
[
1559,
62,
112
],
[
112,
23,
495
]
],
[
[
1559,
63,
1494
],
[
1494,... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Famotidine",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is cau... | Famotidine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ezogabine (Compound)
Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ezog... |
DB01069 | DB04908 | 401 | 1,671 | [
"DDInter1533",
"DDInter741"
] | Promethazine | Flibanserin | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
401,
24,
1671
]
],
[
[
401,
24,
741
],
[
741,
63,
1671
]
],
[
[
401,
24,
830
],
[
830,
24,
1671
]
],
[
[
401,
63,
1594
],
[
1594,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and... |
DB00759 | DB09154 | 1,620 | 1,475 | [
"DDInter1783",
"DDInter1686"
] | Tetracycline | Sodium citrate | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Moderate | 1 | [
[
[
1620,
24,
1475
]
],
[
[
1620,
63,
1252
],
[
1252,
23,
1475
]
],
[
[
1620,
24,
954
],
[
954,
23,
1475
]
],
[
[
1620,
24,
428
],
[
428,
... | [
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium citrate"
]
],
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
... | Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapr... |
DB00490 | DB14723 | 946 | 159 | [
"DDInter254",
"DDInter1026"
] | Buspirone | Larotrectinib | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
946,
24,
159
]
],
[
[
946,
25,
222
],
[
222,
23,
159
]
],
[
[
946,
24,
98
],
[
98,
24,
159
]
],
[
[
946,
63,
530
],
[
530,
24,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Buspirone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutram... | Buspirone may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a m... |
DB00990 | DB11979 | 1,547 | 1,320 | [
"DDInter705",
"DDInter625"
] | Exemestane | Elagolix | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1547,
24,
1320
]
],
[
[
1547,
63,
1249
],
[
1249,
24,
1320
]
],
[
[
1547,
24,
129
],
[
129,
24,
1320
]
],
[
[
1547,
24,
1375
],
[
1375... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
[
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzaluta... |
DB00836 | DB11823 | 543 | 858 | [
"DDInter1088",
"DDInter673"
] | Loperamide | Esketamine | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Moderate | 1 | [
[
[
543,
24,
858
]
],
[
[
543,
24,
272
],
[
272,
24,
858
]
],
[
[
543,
1,
1688
],
[
1688,
24,
858
]
],
[
[
543,
63,
832
],
[
832,
24... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esketamine"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
],
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Loperamide (Compound) resembles Diphenoxylate (Compound) and Diphenoxylate may cause a moderate inte... |
DB00372 | DB01242 | 999 | 1,237 | [
"DDInter1793",
"DDInter410"
] | Thiethylperazine | Clomipramine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
999,
24,
1237
]
],
[
[
999,
25,
684
],
[
684,
1,
1237
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],
[
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999,
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1164
],
[
1164,
1,
1237
]
],
[
[
999,
63,
902
],
[
902,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Thiethylperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
... | Thiethylperazine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (C... |
DB00712 | DB12887 | 1,274 | 1,598 | [
"DDInter763",
"DDInter1750"
] | Flurbiprofen | Tazemetostat | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
1274,
24,
1598
]
],
[
[
1274,
24,
738
],
[
738,
24,
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]
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[
[
1274,
62,
752
],
[
752,
24,
1598
]
],
[
[
1274,
63,
121
],
[
121,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cime... |
DB00059 | DB11652 | 1,560 | 1,155 | [
"DDInter1404",
"DDInter1891"
] | Pegaspargase | Tucatinib | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
1560,
24,
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],
[
[
1560,
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],
[
1101,
23,
1155
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],
[
[
1560,
24,
609
],
[
609,
24,
1155
]
],
[
[
1560,
24,
1421
],
[
1421... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Pegaspargase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarot... | Pegaspargase may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin m... |
DB00515 | DB01250 | 589 | 712 | [
"DDInter387",
"DDInter1334"
] | Cisplatin | Olsalazine | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
589,
24,
712
]
],
[
[
589,
24,
50
],
[
50,
40,
712
]
],
[
[
589,
6,
7720
],
[
7720,
45,
712
]
],
[
[
589,
24,
416
],
[
416,
24,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Cisplatin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Olsalazine (Compound)
Cisplatin may cause a moderate interaction that could exacerbate... |
DB01232 | DB11828 | 1,327 | 1,406 | [
"DDInter1640",
"DDInter1281"
] | Saquinavir | Neratinib | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
1327,
25,
1406
]
],
[
[
1327,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
1327,
25,
392
],
[
392,
24,
1406
]
],
[
[
1327,
63,
1195
],
[
1195... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Saquinavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Saquinavir may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate interaction... |
DB00889 | DB00927 | 1,133 | 1,559 | [
"DDInter840",
"DDInter712"
] | Granisetron | Famotidine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
1133,
24,
1559
]
],
[
[
1133,
18,
10375
],
[
10375,
57,
1559
]
],
[
[
1133,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
1133,
23,
1247
],
[
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Granisetron",
"{u} (Compound) downregulates {v} (Gene)",
"RPS4Y1"
],
[
"RPS4Y1",
"{u} (Gene) is downregulated b... | Granisetron (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Famotidine (Compound)
Granisetron (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Granisetron may cause a minor interaction that can limit clinical effects when taken with Sulf... |
DB00026 | DB00515 | 1,184 | 589 | [
"DDInter94",
"DDInter387"
] | Anakinra | Cisplatin | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
1184,
24,
589
]
],
[
[
1184,
24,
949
],
[
949,
63,
589
]
],
[
[
1184,
24,
58
],
[
58,
24,
589
]
],
[
[
1184,
23,
1461
],
[
1461,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antige... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin
Anakinra may ca... |
DB00220 | DB08881 | 798 | 868 | [
"DDInter1276",
"DDInter1925"
] | Nelfinavir | Vemurafenib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
798,
24,
868
]
],
[
[
798,
6,
8374
],
[
8374,
45,
868
]
],
[
[
798,
7,
3361
],
[
3361,
46,
868
]
],
[
[
798,
18,
5833
],
[
5833,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Nelfinavir (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Vemurafenib (Compound)
Nelfinavir (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Vemurafenib (Compound)
Nelfinavir ... |
DB00631 | DB12147 | 372 | 241 | [
"DDInter405",
"DDInter661"
] | Clofarabine | Erdafitinib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
372,
24,
241
]
],
[
[
372,
24,
384
],
[
384,
24,
241
]
],
[
[
372,
63,
1668
],
[
1668,
24,
241
]
],
[
[
372,
24,
1619
],
[
1619,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and L... |
DB09048 | DB11828 | 555 | 1,406 | [
"DDInter1284",
"DDInter1281"
] | Netupitant | Neratinib | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
555,
25,
1406
]
],
[
[
555,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
555,
63,
1195
],
[
1195,
24,
1406
]
],
[
[
555,
24,
710
],
[
710,
... | [
[
[
"Netupitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Netupitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Netupitant may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Netupitant may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib may cause a moder... |
DB00366 | DB00601 | 1,594 | 453 | [
"DDInter600",
"DDInter1073"
] | Doxylamine | Linezolid | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Major | 2 | [
[
[
1594,
25,
453
]
],
[
[
1594,
18,
18226
],
[
18226,
57,
453
]
],
[
[
1594,
21,
28746
],
[
28746,
60,
453
]
],
[
[
1594,
35,
272
],
[
27... | [
[
[
"Doxylamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Linezolid"
]
],
[
[
"Doxylamine",
"{u} (Compound) downregulates {v} (Gene)",
"GDF15"
],
[
"GDF15",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Doxylamine (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Linezolid (Compound)
Doxylamine (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Linezolid (Compound)
Doxylamine (Compound) resembles Chlorpheniramine (Compound) and Doxylamine may cause a moderate inte... |
DB01320 | DB05679 | 651 | 1,683 | [
"DDInter783",
"DDInter1907"
] | Fosphenytoin | Ustekinumab | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
651,
24,
1683
]
],
[
[
651,
25,
1362
],
[
1362,
63,
1683
]
],
[
[
651,
24,
1093
],
[
1093,
63,
1683
]
],
[
[
651,
63,
281
],
[
281,
... | [
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
],
[
"Olapari... | Fosphenytoin may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab may cause... |
DB00029 | DB00584 | 25 | 610 | [
"DDInter99",
"DDInter638"
] | Anistreplase | Enalapril | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Moderate | 1 | [
[
[
25,
24,
610
]
],
[
[
25,
24,
743
],
[
743,
1,
610
]
],
[
[
25,
24,
954
],
[
954,
40,
610
]
],
[
[
25,
24,
714
],
[
714,
63,
... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
]
],
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
[... | Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril (Compound) resembles Enalapril (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Enalapril (Compound)
... |
DB08899 | DB12364 | 129 | 1,421 | [
"DDInter649",
"DDInter200"
] | Enzalutamide | Betrixaban | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
129,
24,
1421
]
],
[
[
129,
63,
1091
],
[
1091,
24,
1421
]
],
[
[
129,
64,
1513
],
[
1513,
24,
1421
]
],
[
[
129,
25,
1017
],
[
1017,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
... | Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Enzalutamide may lead to a major life threatening interaction when taken with Apremilast and Apremilast may ca... |
DB00353 | DB08824 | 588 | 591 | [
"DDInter1187",
"DDInter959"
] | Methylergometrine | Ioflupane I-123 | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
588,
24,
591
]
],
[
[
588,
21,
28722
],
[
28722,
60,
591
]
],
[
[
588,
1,
107
],
[
107,
24,
591
]
],
[
[
588,
40,
628
],
[
628,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Methylergometrine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Ef... | Methylergometrine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ioflupane I-123 (Compound)
Methylergometrine (Compound) resembles Pergolide (Compound) and Pergolide may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Methylergometrine (Compound)... |
DB00552 | DB00978 | 1,238 | 739 | [
"DDInter1425",
"DDInter1084"
] | Pentostatin | Lomefloxacin | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Minor | 0 | [
[
[
1238,
23,
739
]
],
[
[
1238,
23,
945
],
[
945,
40,
739
]
],
[
[
1238,
62,
1176
],
[
1176,
1,
739
]
],
[
[
1238,
62,
1467
],
[
1467,
... | [
[
[
"Pentostatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Pentostatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
],
[
... | Pentostatin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Pentostatin may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Lomefloxacin (... |
DB00095 | DB00188 | 66 | 168 | [
"DDInter623",
"DDInter222"
] | Efalizumab | Bortezomib | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Moderate | 1 | [
[
[
66,
24,
168
]
],
[
[
66,
24,
1307
],
[
1307,
62,
168
]
],
[
[
66,
63,
58
],
[
58,
24,
168
]
],
[
[
66,
24,
748
],
[
748,
63,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept m... |
DB01157 | DB05679 | 304 | 1,683 | [
"DDInter1875",
"DDInter1907"
] | Trimetrexate | Ustekinumab | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
304,
24,
1683
]
],
[
[
304,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
304,
63,
305
],
[
305,
24,
1683
]
],
[
[
304,
24,
4
],
[
4,
24... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[... | Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escheri... |
DB00697 | DB01075 | 876 | 1,376 | [
"DDInter1821",
"DDInter569"
] | Tizanidine | Diphenhydramine | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
876,
24,
1376
]
],
[
[
876,
24,
649
],
[
649,
63,
1376
]
],
[
[
876,
64,
11
],
[
11,
1,
1376
]
],
[
[
876,
63,
128
],
[
128,
24,... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Tizanidine may lead to a major life threatening interaction when taken with Toremifene and Toremifene (Comp... |
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