drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01225 | DB06779 | 500 | 365 | [
"DDInter645",
"DDInter470"
] | Enoxaparin | Dalteparin | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
500,
25,
365
]
],
[
[
500,
23,
539
],
[
539,
62,
365
]
],
[
[
500,
63,
954
],
[
954,
24,
365
]
],
[
[
500,
24,
1496
],
[
1496,
6... | [
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Enoxaparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Enoxaparin may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril may c... |
DB08865 | DB11837 | 1,593 | 1,297 | [
"DDInter448",
"DDInter1351"
] | Crizotinib | Osilodrostat | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
1593,
25,
1297
]
],
[
[
1593,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
1593,
63,
112
],
[
112,
23,
1297
]
],
[
[
1593,
62,
1247
],
[
1247... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Crizotinib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may ca... |
DB00544 | DB01073 | 970 | 1,488 | [
"DDInter757",
"DDInter745"
] | Fluorouracil | Fludarabine | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
970,
24,
1488
]
],
[
[
970,
24,
372
],
[
372,
1,
1488
]
],
[
[
970,
6,
6882
],
[
6882,
45,
1488
]
],
[
[
970,
21,
28701
],
[
28701,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Fluorouracil (Compound) binds SLC29A1 (Gene) and SLC29A1 (Gene) is bound by Fludarabine (Compound)
Fluorouracil (Compound) causes Discomfort (Side Effect) ... |
DB00906 | DB01611 | 1,567 | 1,487 | [
"DDInter1801",
"DDInter893"
] | Tiagabine | Hydroxychloroquine | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
1567,
24,
1487
]
],
[
[
1567,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
1567,
63,
723
],
[
723,
24,
1487
]
],
[
[
1567,
24,
283
],
[
283... | [
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Tiagabine",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is ... | Tiagabine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Hyd... |
DB00574 | DB00619 | 121 | 1,419 | [
"DDInter717",
"DDInter909"
] | Fenfluramine | Imatinib | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
121,
24,
1419
]
],
[
[
121,
23,
479
],
[
479,
62,
1419
]
],
[
[
121,
64,
1230
],
[
1230,
23,
1419
]
],
[
[
121,
24,
271
],
[
271,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Fenfluramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
... | Fenfluramine may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Imatinib
Fenfluramine may lead to a major life threatening interaction when taken with Citalopram and Citalopram may cause a mi... |
DB00388 | DB00960 | 1,636 | 887 | [
"DDInter1453",
"DDInter1471"
] | Phenylephrine | Pindolol | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Moderate | 1 | [
[
[
1636,
24,
887
]
],
[
[
1636,
63,
726
],
[
726,
1,
887
]
],
[
[
1636,
24,
819
],
[
819,
40,
887
]
],
[
[
1636,
24,
1148
],
[
1148,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betaxolol"
],
[... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Betaxolol and Betaxolol (Compound) resembles Pindolol (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
... |
DB00831 | DB12245 | 1,178 | 823 | [
"DDInter1866",
"DDInter1863"
] | Trifluoperazine | Triclabendazole | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1178,
24,
823
]
],
[
[
1178,
23,
112
],
[
112,
23,
823
]
],
[
[
1178,
63,
1010
],
[
1010,
24,
823
]
],
[
[
1178,
24,
28
],
[
28,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Mefl... |
DB00612 | DB01142 | 1,121 | 1,264 | [
"DDInter216",
"DDInter593"
] | Bisoprolol | Doxepin | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1121,
24,
1264
]
],
[
[
1121,
24,
401
],
[
401,
24,
1264
]
],
[
[
1121,
6,
8374
],
[
8374,
45,
1264
]
],
[
[
1121,
21,
29226
],
[
2922... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Bisoprolol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxepin (Compound)
Bisoprolol (Compound... |
DB00439 | DB06273 | 289 | 980 | [
"DDInter341",
"DDInter1824"
] | Cerivastatin | Tocilizumab | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
289,
24,
980
]
],
[
[
289,
24,
309
],
[
309,
24,
980
]
],
[
[
289,
24,
850
],
[
850,
63,
980
]
],
[
[
289,
63,
168
],
[
168,
24,... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab ve... |
DB00457 | DB00741 | 1,205 | 167 | [
"DDInter1511",
"DDInter885"
] | Prazosin | Hydrocortisone | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
1205,
24,
167
]
],
[
[
1205,
24,
1220
],
[
1220,
40,
167
]
],
[
[
1205,
24,
870
],
[
870,
1,
167
]
],
[
[
1205,
63,
251
],
[
251,
... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[... | Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydroc... |
DB00224 | DB06228 | 215 | 792 | [
"DDInter917",
"DDInter1609"
] | Indinavir | Rivaroxaban | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
215,
24,
792
]
],
[
[
215,
6,
4973
],
[
4973,
45,
792
]
],
[
[
215,
21,
28703
],
[
28703,
60,
792
]
],
[
[
215,
24,
466
],
[
466,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Indinavir",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Indinavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Indinavir (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolut... |
DB03619 | DB09079 | 557 | 1,496 | [
"DDInter501",
"DDInter1296"
] | Deoxycholic acid | Nintedanib | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
557,
24,
1496
]
],
[
[
557,
24,
707
],
[
707,
24,
1496
]
],
[
[
557,
63,
20
],
[
20,
24,
1496
]
],
[
[
557,
24,
235
],
[
235,
63... | [
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danaparoid"
... | Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Tenectepl... |
DB00333 | DB01191 | 576 | 1,039 | [
"DDInter1166",
"DDInter518"
] | Methadone | Dexfenfluramine | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
576,
24,
1039
]
],
[
[
576,
6,
10215
],
[
10215,
45,
1039
]
],
[
[
576,
24,
578
],
[
578,
63,
1039
]
],
[
[
576,
25,
868
],
[
868,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compou... | Methadone (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexfenfluramine (Compound)
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Methadon... |
DB00586 | DB01067 | 1,512 | 959 | [
"DDInter537",
"DDInter826"
] | Diclofenac | Glipizide | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1512,
24,
959
]
],
[
[
1512,
63,
245
],
[
245,
40,
959
]
],
[
[
1512,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1512,
6,
8374
],
[
8374,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound... |
DB06595 | DB11932 | 1,491 | 327 | [
"DDInter1214",
"DDInter3"
] | Midostaurin | Abametapir (topical) | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1491,
24,
327
]
],
[
[
1491,
24,
124
],
[
124,
63,
327
]
],
[
[
1491,
63,
613
],
[
613,
24,
327
]
],
[
[
1491,
64,
1069
],
[
1069,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Midostauri... |
DB00069 | DB01098 | 367 | 14 | [
"DDInter946",
"DDInter1622"
] | Interferon alfacon-1 | Rosuvastatin | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
367,
24,
14
]
],
[
[
367,
24,
671
],
[
671,
24,
14
]
],
[
[
367,
63,
305
],
[
305,
24,
14
]
],
[
[
367,
24,
1060
],
[
1060,
63,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluva... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00163 | DB01592 | 1,461 | 1,596 | [
"DDInter1943",
"DDInter975"
] | Vitamin E | Iron | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
1461,
24,
1596
]
],
[
[
1461,
23,
1096
],
[
1096,
23,
1596
]
],
[
[
1461,
24,
489
],
[
489,
63,
1596
]
],
[
[
1461,
23,
1096
],
[
1096... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mycophenolic acid"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Iron
sucrose and Iron sucrose may cause a moderate interaction that could exacerbate diseases when taken with Iron... |
DB00622 | DB11569 | 1,081 | 1,093 | [
"DDInter1287",
"DDInter1003"
] | Nicardipine | Ixekizumab | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
1081,
24,
1093
]
],
[
[
1081,
24,
1683
],
[
1683,
24,
1093
]
],
[
[
1081,
40,
376
],
[
376,
24,
1093
]
],
[
[
1081,
63,
58
],
[
58,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
[... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Nicardipine (Compound) resembles Amlodipine (Compound) and Amlodipine may cause a moderate interaction that c... |
DB00783 | DB01124 | 1,438 | 1,411 | [
"DDInter679",
"DDInter1828"
] | Estradiol | Tolbutamide | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1438,
24,
1411
]
],
[
[
1438,
24,
959
],
[
959,
40,
1411
]
],
[
[
1438,
63,
245
],
[
245,
40,
1411
]
],
[
[
1438,
6,
10215
],
[
10215,... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
... |
DB01182 | DB12245 | 371 | 823 | [
"DDInter1534",
"DDInter1863"
] | Propafenone | Triclabendazole | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
371,
24,
823
]
],
[
[
371,
62,
112
],
[
112,
23,
823
]
],
[
[
371,
63,
1010
],
[
1010,
24,
823
]
],
[
[
371,
24,
28
],
[
28,
24,... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Propafenone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Propafenone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine a... |
DB00431 | DB09068 | 1,503 | 1,427 | [
"DDInter1072",
"DDInter1948"
] | Lindane | Vortioxetine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1503,
24,
1427
]
],
[
[
1503,
24,
129
],
[
129,
24,
1427
]
],
[
[
1503,
24,
913
],
[
913,
63,
1427
]
],
[
[
1503,
63,
475
],
[
475,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalu... |
DB06176 | DB13179 | 1,342 | 68 | [
"DDInter1616",
"DDInter1882"
] | Romidepsin | Troleandomycin | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
1342,
24,
68
]
],
[
[
1342,
63,
1374
],
[
1374,
23,
68
]
],
[
[
1342,
24,
1662
],
[
1662,
24,
68
]
],
[
[
1342,
63,
1151
],
[
1151,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid... |
DB00418 | DB04845 | 536 | 309 | [
"DDInter1650",
"DDInter1001"
] | Secobarbital | Ixabepilone | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
536,
24,
309
]
],
[
[
536,
21,
28882
],
[
28882,
60,
309
]
],
[
[
536,
24,
1419
],
[
1419,
24,
309
]
],
[
[
536,
40,
697
],
[
697,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Secobarbital",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature incre... | Secobarbital (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Ixabepilone (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerba... |
DB06176 | DB12161 | 1,342 | 730 | [
"DDInter1616",
"DDInter512"
] | Romidepsin | Deutetrabenazine | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
1342,
24,
730
]
],
[
[
1342,
62,
112
],
[
112,
23,
730
]
],
[
[
1342,
63,
322
],
[
322,
24,
730
]
],
[
[
1342,
24,
971
],
[
971,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin an... |
DB00059 | DB05773 | 1,560 | 1,047 | [
"DDInter1404",
"DDInter1848"
] | Pegaspargase | Trastuzumab emtansine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
1560,
24,
1047
]
],
[
[
1560,
24,
848
],
[
848,
24,
1047
]
],
[
[
1560,
25,
375
],
[
375,
63,
1047
]
],
[
[
1560,
24,
242
],
[
242,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Pegaspargase may lead to a major life threatening interaction when taken with Certolizumab pegol and ... |
DB00008 | DB08895 | 491 | 976 | [
"DDInter1407",
"DDInter1825"
] | Peginterferon alfa-2a | Tofacitinib | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
491,
25,
976
]
],
[
[
491,
25,
534
],
[
534,
24,
976
]
],
[
[
491,
24,
1430
],
[
1430,
24,
976
]
],
[
[
491,
24,
1580
],
[
1580,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tramadol"
],
[
"Tram... | Peginterferon alfa-2a may lead to a major life threatening interaction when taken with Tramadol and Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and ... |
DB00557 | DB06663 | 252 | 1,154 | [
"DDInter895",
"DDInter1398"
] | Hydroxyzine | Pasireotide | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
252,
25,
1154
]
],
[
[
252,
21,
28762
],
[
28762,
60,
1154
]
],
[
[
252,
23,
112
],
[
112,
23,
1154
]
],
[
[
252,
24,
1662
],
[
1662,
... | [
[
[
"Hydroxyzine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Com... | Hydroxyzine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Pasireotide (Compound)
Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pasi... |
DB00446 | DB01227 | 597 | 1,301 | [
"DDInter351",
"DDInter1043"
] | Chloramphenicol | Levacetylmethadol | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Major | 2 | [
[
[
597,
25,
1301
]
],
[
[
597,
23,
307
],
[
307,
1,
1301
]
],
[
[
597,
63,
576
],
[
576,
1,
1301
]
],
[
[
597,
6,
8374
],
[
8374,
4... | [
[
[
"Chloramphenicol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Chloramphenicol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Chloramphenicol may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Levacetylmethadol (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Levacetylme... |
DB00206 | DB00907 | 1,245 | 290 | [
"DDInter1582",
"DDInter427"
] | Reserpine | Cocaine (topical) | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Major | 2 | [
[
[
1245,
25,
290
]
],
[
[
1245,
6,
8803
],
[
8803,
45,
290
]
],
[
[
1245,
21,
28676
],
[
28676,
60,
290
]
],
[
[
1245,
24,
1636
],
[
1636... | [
[
[
"Reserpine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cocaine"
]
],
[
[
"Reserpine",
"{u} (Compound) binds {v} (Gene)",
"SLC22A2"
],
[
"SLC22A2",
"{u} (Gene) is bound by {v} (Compound)",
"Cocaine"
... | Reserpine may lead to a major life threatening interaction when taken with Cocaine
Reserpine (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Cocaine (Compound)
Reserpine (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Cocaine (Compound)
Reserpine may cause a moderat... |
DB01076 | DB09122 | 700 | 1,613 | [
"DDInter133",
"DDInter1409"
] | Atorvastatin | Peginterferon beta-1a | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
700,
24,
1613
]
],
[
[
700,
40,
671
],
[
671,
24,
1613
]
],
[
[
700,
64,
600
],
[
600,
24,
1613
]
],
[
[
700,
63,
168
],
[
168,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Atorvastatin",
"{u} (Compound) resembles {v} (Compound)",
"Fluvastatin"
],
[
"Fluvastatin",
"{u} ma... | Atorvastatin (Compound) resembles Fluvastatin (Compound) and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Atorvastatin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that c... |
DB00015 | DB01009 | 582 | 935 | [
"DDInter1585",
"DDInter1009"
] | Reteplase | Ketoprofen | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
582,
24,
935
]
],
[
[
582,
24,
1274
],
[
1274,
24,
935
]
],
[
[
582,
24,
1263
],
[
1263,
1,
935
]
],
[
[
582,
25,
1046
],
[
1046,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromf... |
DB00158 | DB00263 | 356 | 1,029 | [
"DDInter771",
"DDInter1727"
] | Folic acid | Sulfisoxazole | Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic aci... | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Moderate | 1 | [
[
[
356,
24,
1029
]
],
[
[
356,
24,
1247
],
[
1247,
40,
1029
]
],
[
[
356,
24,
161
],
[
161,
1,
1029
]
],
[
[
356,
35,
663
],
[
663,
... | [
[
[
"Folic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfisoxazole"
]
],
[
[
"Folic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],... | Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole (Compound) resembles Sulfisoxazole (Compound)
Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sul... |
DB00153 | DB01021 | 1,331 | 674 | [
"DDInter662",
"DDInter1861"
] | Ergocalciferol | Trichlormethiazide | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
1331,
24,
674
]
],
[
[
1331,
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],
[
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],
[
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[
178,
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],
[
[
1331,
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603
],
[
603,
... | [
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazid... | Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resemble... |
DB00280 | DB01177 | 494 | 77 | [
"DDInter575",
"DDInter904"
] | Disopyramide | Idarubicin | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
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112,
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[
[
494,
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[
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63... | [
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[
"Disopyramide",
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"Idarubicin"
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],
[
[
"Disopyramide",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac failure congestive"
],
[
"Cardiac failure congestive",
"{u... | Disopyramide (Compound) causes Cardiac failure congestive (Side Effect) and Cardiac failure congestive (Side Effect) is caused by Idarubicin (Compound)
Disopyramide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit ... |
DB00477 | DB09043 | 216 | 135 | [
"DDInter363",
"DDInter36"
] | Chlorpromazine | Albiglutide | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
216,
24,
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[
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216,
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[
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[
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216,
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],
[
870,
24,
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]
],
[
[
216,
63,
176
],
[
176,
2... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone an... |
DB00011 | DB08903 | 1,451 | 996 | [
"DDInter944",
"DDInter170"
] | Interferon alfa-n1 | Bedaquiline | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
1451,
24,
996
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],
[
[
1451,
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],
[
112,
23,
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]
],
[
[
1451,
24,
713
],
[
713,
63,
996
]
],
[
[
1451,
25,
593
],
[
593,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidaz... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bedaquiline
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00488 | DB01610 | 196 | 248 | [
"DDInter57",
"DDInter1912"
] | Altretamine | Valganciclovir | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
196,
24,
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]
],
[
[
196,
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],
[
563,
1,
248
]
],
[
[
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21,
29209
],
[
29209,
60,
248
]
],
[
[
196,
25,
507
],
[
507,
... | [
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Altretamine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Altretamine may lead to a major li... |
DB00307 | DB01215 | 1,101 | 1,418 | [
"DDInter202",
"DDInter677"
] | Bexarotene | Estazolam | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
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1101,
24,
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[
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[
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1101,
6,
8374
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[
8374,
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[
[
1101,
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28789
],
[
28789... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Estazolam (Compound)
Bexarotene (Compound) causes Loss of consciousness (Side Effect) and... |
DB00427 | DB00708 | 1,233 | 1,454 | [
"DDInter1879",
"DDInter1718"
] | Triprolidine | Sufentanil | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Moderate | 1 | [
[
[
1233,
24,
1454
]
],
[
[
1233,
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],
[
704,
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[
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],
[
537,
63,
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]
],
[
[
1233,
24,
85
],
[
85,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could e... |
DB00999 | DB08882 | 504 | 1,281 | [
"DDInter883",
"DDInter1070"
] | Hydrochlorothiazide | Linagliptin | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
504,
24,
1281
]
],
[
[
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],
[
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[
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],
[
28966,
60,
1281
]
],
[
[
504,
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251
],
[
251,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aloglipt... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Hydrochlorothiazide (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by... |
DB00006 | DB00086 | 942 | 1,167 | [
"DDInter217",
"DDInter1712"
] | Bivalirudin | Streptokinase | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Major | 2 | [
[
[
942,
25,
1167
]
],
[
[
942,
23,
539
],
[
539,
62,
1167
]
],
[
[
942,
24,
992
],
[
992,
63,
1167
]
],
[
[
942,
24,
1595
],
[
1595,
... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Streptokinase"
]
],
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum"... | Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Streptokinase
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ginger and Ginger may ca... |
DB00518 | DB11652 | 510 | 1,155 | [
"DDInter35",
"DDInter1891"
] | Albendazole | Tucatinib | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
510,
24,
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[
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[
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[
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510,
24,
214
],
[
214,
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1155
]
],
[
[
510,
23,
1220
],
[
1220,
... | [
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fosta... |
DB00443 | DB11640 | 251 | 1,267 | [
"DDInter195",
"DDInter64"
] | Betamethasone | Amifampridine | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
251,
24,
1267
]
],
[
[
251,
1,
1220
],
[
1220,
24,
1267
]
],
[
[
251,
40,
870
],
[
870,
24,
1267
]
],
[
[
251,
24,
61
],
[
61,
2... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Betamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
"Dexamethasone",
"{u} may ... | Betamethasone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Betamethasone (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases wh... |
DB01156 | DB01235 | 593 | 1,191 | [
"DDInter252",
"DDInter1054"
] | Bupropion | Levodopa | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
593,
24,
1191
]
],
[
[
593,
6,
12523
],
[
12523,
45,
1191
]
],
[
[
593,
7,
7972
],
[
7972,
46,
1191
]
],
[
[
593,
21,
28936
],
[
28936... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Bupropion",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Bupropion (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Levodopa (Compound)
Bupropion (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Levodopa (Compound)
Bupropion (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Levodopa (Compound)
Bup... |
DB01232 | DB06655 | 1,327 | 5 | [
"DDInter1640",
"DDInter1077"
] | Saquinavir | Liraglutide | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1327,
24,
5
]
],
[
[
1327,
63,
353
],
[
353,
23,
5
]
],
[
[
1327,
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1142
],
[
1142,
24,
5
]
],
[
[
1327,
1,
915
],
[
915,
24,
... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Griseofulvin"
],
[... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlis... |
DB06448 | DB14723 | 171 | 159 | [
"DDInter1087",
"DDInter1026"
] | Lonafarnib | Larotrectinib | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Major | 2 | [
[
[
171,
25,
159
]
],
[
[
171,
62,
222
],
[
222,
23,
159
]
],
[
[
171,
24,
466
],
[
466,
23,
159
]
],
[
[
171,
25,
1135
],
[
1135,
2... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
]
],
[
[
"Lonafarnib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
"Sibutram... | Lonafarnib may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Dar... |
DB00674 | DB01142 | 1,516 | 1,264 | [
"DDInter802",
"DDInter593"
] | Galantamine | Doxepin | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1516,
24,
1264
]
],
[
[
1516,
24,
401
],
[
401,
24,
1264
]
],
[
[
1516,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
1516,
6,
8374
],
[
8374,... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Dox... |
DB00490 | DB04837 | 946 | 649 | [
"DDInter254",
"DDInter407"
] | Buspirone | Clofedanol | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
946,
24,
649
]
],
[
[
946,
24,
1376
],
[
1376,
24,
649
]
],
[
[
946,
24,
832
],
[
832,
40,
649
]
],
[
[
946,
63,
701
],
[
701,
2... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamin... |
DB06800 | DB11791 | 1,159 | 785 | [
"DDInter1188",
"DDInter287"
] | Methylnaltrexone | Capmatinib | Methylnaltrexone is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation without producing analgesic effects or withdrawal symptoms. It is also a weak CYP2D6 inhibitor. FDA approved in 2008. | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
1159,
24,
785
]
],
[
[
1159,
24,
1135
],
[
1135,
23,
785
]
],
[
[
1159,
24,
1499
],
[
1499,
24,
785
]
],
[
[
1159,
74,
267
],
[
267,
... | [
[
[
"Methylnaltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Methylnaltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
... | Methylnaltrexone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Capmatinib
Methylnaltrexone may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine a... |
DB00619 | DB06228 | 1,419 | 792 | [
"DDInter909",
"DDInter1609"
] | Imatinib | Rivaroxaban | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1419,
24,
792
]
],
[
[
1419,
6,
4973
],
[
4973,
45,
792
]
],
[
[
1419,
21,
28703
],
[
28703,
60,
792
]
],
[
[
1419,
23,
307
],
[
307,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Imatinib (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Imatinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may c... |
DB01030 | DB12147 | 869 | 241 | [
"DDInter1835",
"DDInter661"
] | Topotecan | Erdafitinib | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
869,
24,
241
]
],
[
[
869,
24,
1456
],
[
1456,
24,
241
]
],
[
[
869,
63,
1668
],
[
1668,
24,
241
]
],
[
[
869,
24,
1619
],
[
1619,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and Lenal... |
DB00912 | DB01050 | 473 | 848 | [
"DDInter1581",
"DDInter900"
] | Repaglinide | Ibuprofen | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
473,
24,
848
]
],
[
[
473,
6,
1829
],
[
1829,
45,
848
]
],
[
[
473,
21,
28864
],
[
28864,
60,
848
]
],
[
[
473,
63,
752
],
[
752,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Repaglinide",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Repaglinide (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Repaglinide (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Ibuprofen (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Cime... |
DB00358 | DB00468 | 1,010 | 1,424 | [
"DDInter1140",
"DDInter1557"
] | Mefloquine | Quinine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Moderate | 1 | [
[
[
1010,
24,
1424
]
],
[
[
1010,
6,
4973
],
[
4973,
45,
1424
]
],
[
[
1010,
7,
4649
],
[
4649,
46,
1424
]
],
[
[
1010,
18,
3696
],
[
3696... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Quinine (Compound)
Mefloquine (Compound) upregulates CPVL (Gene) and CPVL (Gene) is upregulated by Quinine (Compound)
Mefloquine (Compound) downregulates ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Quinine (Compound)
Mefloquine (Compound) cause... |
DB00361 | DB12010 | 134 | 214 | [
"DDInter1939",
"DDInter785"
] | Vinorelbine | Fostamatinib | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
134,
24,
214
]
],
[
[
134,
25,
976
],
[
976,
24,
214
]
],
[
[
134,
24,
723
],
[
723,
24,
214
]
],
[
[
134,
63,
10
],
[
10,
24,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofac... | Vinorelbine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may ... |
DB01001 | DB11642 | 688 | 938 | [
"DDInter1632",
"DDInter1480"
] | Salbutamol | Pitolisant | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
688,
24,
938
]
],
[
[
688,
62,
112
],
[
112,
23,
938
]
],
[
[
688,
24,
28
],
[
28,
24,
938
]
],
[
[
688,
63,
600
],
[
600,
24,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisac... |
DB00283 | DB00427 | 701 | 1,233 | [
"DDInter395",
"DDInter1879"
] | Clemastine | Triprolidine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
701,
24,
1233
]
],
[
[
701,
1,
11268
],
[
11268,
40,
1233
]
],
[
[
701,
6,
12523
],
[
12523,
45,
1233
]
],
[
[
701,
18,
7359
],
[
7359... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Clemastine",
"{u} (Compound) resembles {v} (Compound)",
"Cloperastine"
],
[
"Cloperastine",
"{u} (Compound) re... | Clemastine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Triprolidine (Compound)
Clemastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Triprolidine (Compound)
Clemastine (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Triprolidine (Comp... |
DB00507 | DB00682 | 316 | 126 | [
"DDInter1299",
"DDInter1951"
] | Nitazoxanide | Warfarin | Nitazoxanide belongs to the class of drugs known as _thiazolides_. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses.... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
316,
24,
126
]
],
[
[
316,
40,
345
],
[
345,
40,
126
]
],
[
[
316,
63,
362
],
[
362,
24,
126
]
],
[
[
316,
24,
663
],
[
663,
23,... | [
[
[
"Nitazoxanide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Nitazoxanide",
"{u} (Compound) resembles {v} (Compound)",
"Salsalate"
],
[
"Salsalate",
"{u} (Compound) resemble... | Nitazoxanide (Compound) resembles Salsalate (Compound) and Salsalate (Compound) resembles Warfarin (Compound)
Nitazoxanide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Nita... |
DB00451 | DB01221 | 542 | 1,190 | [
"DDInter1064",
"DDInter1007"
] | Levothyroxine | Ketamine | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
542,
24,
1190
]
],
[
[
542,
6,
8374
],
[
8374,
45,
1190
]
],
[
[
542,
21,
28642
],
[
28642,
60,
1190
]
],
[
[
542,
63,
73
],
[
73,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Levothyroxine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Levothyroxine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ketamine (Compound)
Levothyroxine (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Ketamine (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phente... |
DB00834 | DB01229 | 932 | 973 | [
"DDInter1215",
"DDInter1377"
] | Mifepristone | Paclitaxel | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
932,
24,
973
]
],
[
[
932,
24,
310
],
[
310,
63,
973
]
],
[
[
932,
6,
7524
],
[
7524,
45,
973
]
],
[
[
932,
7,
3466
],
[
3466,
4... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Mifepristone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Mifepristone... |
DB00209 | DB01238 | 352 | 673 | [
"DDInter1886",
"DDInter118"
] | Trospium | Aripiprazole | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
352,
24,
673
]
],
[
[
352,
24,
1630
],
[
1630,
1,
673
]
],
[
[
352,
6,
4304
],
[
4304,
45,
673
]
],
[
[
352,
21,
28827
],
[
28827,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Compound)
Trospium (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Aripiprazole (Compound)
Trospium (Compound) causes Orthostatic hypotension (Side Effect)... |
DB00980 | DB06282 | 969 | 516 | [
"DDInter1564",
"DDInter1053"
] | Ramelteon | Levocetirizine | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
969,
24,
516
]
],
[
[
969,
63,
701
],
[
701,
24,
516
]
],
[
[
969,
24,
407
],
[
407,
63,
516
]
],
[
[
969,
24,
1688
],
[
1688,
2... | [
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may... |
DB00960 | DB01249 | 887 | 258 | [
"DDInter1471",
"DDInter958"
] | Pindolol | Iodixanol | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Moderate | 1 | [
[
[
887,
24,
258
]
],
[
[
887,
24,
497
],
[
497,
1,
258
]
],
[
[
887,
7,
2384
],
[
2384,
46,
258
]
],
[
[
887,
21,
28748
],
[
28748,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
]
],
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
],
[
"Ioh... | Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Pindolol (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Iodixanol (Compound)
Pindolol (Compound) causes Vertigo (Side Effect) and Vertigo (Side Eff... |
DB06212 | DB09075 | 165 | 498 | [
"DDInter1833",
"DDInter621"
] | Tolvaptan | Edoxaban | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
165,
24,
498
]
],
[
[
165,
24,
1017
],
[
1017,
63,
498
]
],
[
[
165,
25,
129
],
[
129,
24,
498
]
],
[
[
165,
63,
305
],
[
305,
2... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Tolvaptan may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause ... |
DB00277 | DB00827 | 1,031 | 646 | [
"DDInter1791",
"DDInter383"
] | Theophylline | Cinoxacin | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Moderate | 1 | [
[
[
1031,
24,
646
]
],
[
[
1031,
21,
28722
],
[
28722,
60,
646
]
],
[
[
1031,
24,
1503
],
[
1503,
24,
646
]
],
[
[
1031,
23,
417
],
[
417,... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cinoxacin"
]
],
[
[
"Theophylline",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused ... | Theophylline (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Cinoxacin (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Lindane and Lindane may cause a moderate interaction that could exacerbate diseases when taken with Cinoxacin
Theoph... |
DB00916 | DB01045 | 112 | 463 | [
"DDInter1202",
"DDInter1590"
] | Metronidazole | Rifampicin | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
112,
24,
463
]
],
[
[
112,
63,
690
],
[
690,
40,
463
]
],
[
[
112,
6,
6017
],
[
6017,
45,
463
]
],
[
[
112,
23,
1264
],
[
1264,
... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Metronidazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Rifampicin (Compound)
Metronidazole may cause a minor interaction that can limit cli... |
DB00773 | DB01059 | 896 | 956 | [
"DDInter702",
"DDInter1313"
] | Etoposide | Norfloxacin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Minor | 0 | [
[
[
896,
23,
956
]
],
[
[
896,
23,
872
],
[
872,
40,
956
]
],
[
[
896,
62,
1176
],
[
1176,
1,
956
]
],
[
[
896,
23,
1539
],
[
1539,
... | [
[
[
"Etoposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Norfloxacin"
]
],
[
[
"Etoposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
],
[
... | Etoposide may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Etoposide may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compou... |
DB00472 | DB03904 | 758 | 1,574 | [
"DDInter758",
"DDInter1903"
] | Fluoxetine | Urea | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Moderate | 1 | [
[
[
758,
24,
1574
]
],
[
[
758,
63,
1314
],
[
1314,
24,
1574
]
],
[
[
758,
24,
657
],
[
657,
63,
1574
]
],
[
[
758,
1,
109
],
[
109,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Urea"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Urea
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Castor oil and Castor o... |
DB08882 | DB11652 | 1,281 | 1,155 | [
"DDInter1070",
"DDInter1891"
] | Linagliptin | Tucatinib | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
1281,
24,
1155
]
],
[
[
1281,
63,
222
],
[
222,
23,
1155
]
],
[
[
1281,
64,
1101
],
[
1101,
23,
1155
]
],
[
[
1281,
24,
659
],
[
659,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Linagliptin may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause... |
DB00480 | DB08901 | 1,668 | 1,468 | [
"DDInter1035",
"DDInter1492"
] | Lenalidomide | Ponatinib | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1668,
24,
1468
]
],
[
[
1668,
24,
478
],
[
478,
24,
1468
]
],
[
[
1668,
6,
4973
],
[
4973,
45,
1468
]
],
[
[
1668,
18,
20113
],
[
2011... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Lenalidomide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ponatinib (Compound)
Lenalidomide (Compou... |
DB00307 | DB00957 | 1,101 | 873 | [
"DDInter202",
"DDInter1314"
] | Bexarotene | Norgestimate | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with [ethinylestradiol] as a combined oral contraceptive that can also be used to treat mod... | Major | 2 | [
[
[
1101,
25,
873
]
],
[
[
1101,
24,
989
],
[
989,
1,
873
]
],
[
[
1101,
25,
566
],
[
566,
1,
873
]
],
[
[
1101,
64,
1657
],
[
1657,
... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norgestimate"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
],
[
"Proges... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resembles Norgestimate (Compound)
Bexarotene may lead to a major life threatening interaction when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Norgestimate (Compound)... |
DB00615 | DB08884 | 690 | 796 | [
"DDInter1589",
"DDInter800"
] | Rifabutin | Gadoxetic acid | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up ... | Moderate | 1 | [
[
[
690,
24,
796
]
],
[
[
690,
21,
28841
],
[
28841,
60,
796
]
],
[
[
690,
40,
463
],
[
463,
24,
796
]
],
[
[
690,
21,
28841
],
[
28841,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoxetic acid"
]
],
[
[
"Rifabutin",
"{u} (Compound) causes {v} (Side Effect)",
"Bronchospasm"
],
[
"Bronchospasm",
"{u} (Side Effect)... | Rifabutin (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Gadoxetic acid (Compound)
Rifabutin (Compound) resembles Rifampicin (Compound) and Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Gadoxetic acid
Rifabutin (Compound) causes Bron... |
DB00384 | DB01105 | 1,275 | 222 | [
"DDInter1859",
"DDInter1665"
] | Triamterene | Sibutramine | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1275,
24,
222
]
],
[
[
1275,
21,
28921
],
[
28921,
60,
222
]
],
[
[
1275,
23,
752
],
[
752,
23,
222
]
],
[
[
1275,
24,
802
],
[
802,
... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Triamterene",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is c... | Triamterene (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sibutramine (Compound)
Triamterene may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Sibutram... |
DB00220 | DB00907 | 798 | 290 | [
"DDInter1276",
"DDInter427"
] | Nelfinavir | Cocaine (topical) | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
798,
24,
290
]
],
[
[
798,
6,
21998
],
[
21998,
45,
290
]
],
[
[
798,
21,
28741
],
[
28741,
60,
290
]
],
[
[
798,
25,
629
],
[
629,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by {... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Nelfinavir (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Cocaine (Compound)
Nelfinavir (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Cocaine (Compound)... |
DB00175 | DB05773 | 681 | 1,047 | [
"DDInter1509",
"DDInter1848"
] | Pravastatin | Trastuzumab emtansine | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
681,
24,
1047
]
],
[
[
681,
24,
375
],
[
375,
63,
1047
]
],
[
[
681,
24,
458
],
[
458,
24,
1047
]
],
[
[
681,
35,
467
],
[
467,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab p... | Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol and Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Pravastatin may cause a moderate interaction that could exacerbate diseases when tak... |
DB00014 | DB00363 | 521 | 695 | [
"DDInter839",
"DDInter419"
] | Goserelin | Clozapine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
521,
25,
695
]
],
[
[
521,
24,
1178
],
[
1178,
1,
695
]
],
[
[
521,
24,
623
],
[
623,
40,
695
]
],
[
[
521,
23,
112
],
[
112,
62... | [
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
[
"Trifluop... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Clozapine (Comp... |
DB00539 | DB01403 | 11 | 9 | [
"DDInter1837",
"DDInter1175"
] | Toremifene | Methotrimeprazine | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Major | 2 | [
[
[
11,
25,
9
]
],
[
[
11,
25,
1178
],
[
1178,
40,
9
]
],
[
[
11,
25,
1164
],
[
1164,
1,
9
]
],
[
[
11,
25,
401
],
[
401,
24,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluoperazine"
],
[
"Trifluoperazi... | Toremifene may lead to a major life threatening interaction when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Toremifene may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Methotrimeprazine (Compound)
To... |
DB01064 | DB06176 | 1,148 | 1,342 | [
"DDInter987",
"DDInter1616"
] | Isoprenaline | Romidepsin | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1148,
24,
1342
]
],
[
[
1148,
63,
956
],
[
956,
24,
1342
]
],
[
[
1148,
24,
1520
],
[
1520,
24,
1342
]
],
[
[
1148,
24,
1616
],
[
1616... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and ... |
DB00011 | DB09054 | 1,451 | 384 | [
"DDInter944",
"DDInter905"
] | Interferon alfa-n1 | Idelalisib | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1451,
24,
384
]
],
[
[
1451,
24,
1627
],
[
1627,
62,
384
]
],
[
[
1451,
25,
72
],
[
72,
24,
384
]
],
[
[
1451,
24,
305
],
[
305,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Interferon alfa-n1 may lead to a major life threatening interaction when taken with Eltrombopag and Eltr... |
DB00687 | DB00951 | 870 | 1,072 | [
"DDInter747",
"DDInter986"
] | Fludrocortisone | Isoniazid | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Minor | 0 | [
[
[
870,
23,
1072
]
],
[
[
870,
21,
29333
],
[
29333,
60,
1072
]
],
[
[
870,
1,
1486
],
[
1486,
62,
1072
]
],
[
[
870,
23,
115
],
[
115,
... | [
[
[
"Fludrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Isoniazid"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Optic neuritis"
],
[
"Optic neuritis",
"{u} (Sid... | Fludrocortisone (Compound) causes Optic neuritis (Side Effect) and Optic neuritis (Side Effect) is caused by Isoniazid (Compound)
Fludrocortisone (Compound) resembles Methylprednisolone (Compound) and Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Isoniazid
Fludrocortis... |
DB00804 | DB01233 | 1,507 | 1,311 | [
"DDInter543",
"DDInter1197"
] | Dicyclomine | Metoclopramide | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1507,
24,
1311
]
],
[
[
1507,
63,
1425
],
[
1425,
40,
1311
]
],
[
[
1507,
6,
7992
],
[
7992,
45,
1311
]
],
[
[
1507,
21,
28691
],
[
28... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisapride"
],
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Cisapride and Cisapride (Compound) resembles Metoclopramide (Compound)
Dicyclomine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Metoclopramide (Compound)
Dicyclomine (Compound) causes Somnolence (Side Effect) and S... |
DB00812 | DB09156 | 998 | 777 | [
"DDInter1451",
"DDInter964"
] | Phenylbutazone | Iopromide | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Major | 2 | [
[
[
998,
25,
777
]
],
[
[
998,
63,
372
],
[
372,
25,
777
]
],
[
[
998,
24,
712
],
[
712,
25,
777
]
],
[
[
998,
64,
663
],
[
663,
25,... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iopromide"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
"Cl... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may lead to a major life threatening interaction when taken with Iopromide
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine m... |
DB00317 | DB00563 | 883 | 663 | [
"DDInter810",
"DDInter1174"
] | Gefitinib | Methotrexate | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
883,
24,
663
]
],
[
[
883,
5,
11582
],
[
11582,
44,
663
]
],
[
[
883,
6,
4973
],
[
4973,
45,
663
]
],
[
[
883,
18,
8569
],
[
8569,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Gefitinib",
"{u} (Compound) treats {v} (Disease)",
"lung cancer"
],
[
"lung cancer",
"{u} (Disease) is treated ... | Gefitinib (Compound) treats lung cancer (Disease) and lung cancer (Disease) is treated by Methotrexate (Compound)
Gefitinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound)
Gefitinib (Compound) downregulates TYMS (Gene) and TYMS (Gene) is bound by Methotrexate (Compound)
Gefitinib (Com... |
DB06402 | DB09268 | 1,079 | 1,662 | [
"DDInter1756",
"DDInter1464"
] | Telavancin | Picosulfuric acid | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1079,
24,
1662
]
],
[
[
1079,
24,
484
],
[
484,
63,
1662
]
],
[
[
1079,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
1079,
24,
1491
],
[
1491... | [
[
[
"Telavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Telavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
... | Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Telavancin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantin... |
DB00322 | DB06168 | 141 | 1,531 | [
"DDInter742",
"DDInter281"
] | Floxuridine | Canakinumab | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
141,
24,
1531
]
],
[
[
141,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
141,
63,
377
],
[
377,
24,
1531
]
],
[
[
141,
24,
1270
],
[
1270,
... | [
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomyci... |
DB00636 | DB01067 | 429 | 959 | [
"DDInter408",
"DDInter826"
] | Clofibrate | Glipizide | A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986) | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
429,
24,
959
]
],
[
[
429,
63,
245
],
[
245,
40,
959
]
],
[
[
429,
24,
1411
],
[
1411,
1,
959
]
],
[
[
429,
6,
8374
],
[
8374,
4... | [
[
[
"Clofibrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Clofibrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Clofibrate may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Clofibrate may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound... |
DB09128 | DB09488 | 1,241 | 103 | [
"DDInter231",
"DDInter23"
] | Brexpiprazole | Acrivastine | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1241,
24,
103
]
],
[
[
1241,
63,
85
],
[
85,
24,
103
]
],
[
[
1241,
64,
1376
],
[
1376,
24,
103
]
],
[
[
1241,
63,
85
],
[
85,
2... | [
[
[
"Brexpiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Brexpiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
... | Brexpiprazole may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Brexpiprazole may lead to a major life threatening interaction when taken with Diphenhydramine and Diphenhydrami... |
DB01220 | DB12015 | 1,088 | 1,033 | [
"DDInter1593",
"DDInter53"
] | Rifaximin | Alpelisib | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1088,
24,
1033
]
],
[
[
1088,
24,
1510
],
[
1510,
24,
1033
]
],
[
[
1088,
63,
126
],
[
126,
24,
1033
]
],
[
[
1088,
24,
971
],
[
971,
... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
],
[
... | Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfa... |
DB01124 | DB14006 | 1,411 | 972 | [
"DDInter1828",
"DDInter370"
] | Tolbutamide | Choline salicylate | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1411,
24,
972
]
],
[
[
1411,
62,
660
],
[
660,
23,
972
]
],
[
[
1411,
63,
1573
],
[
1573,
24,
972
]
],
[
[
1411,
24,
1117
],
[
1117,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Tolbutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
]... | Tolbutamide may cause a minor interaction that can limit clinical effects when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone ... |
DB00604 | DB05316 | 1,425 | 749 | [
"DDInter385",
"DDInter1467"
] | Cisapride | Pimavanserin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Major | 2 | [
[
[
1425,
25,
749
]
],
[
[
1425,
23,
112
],
[
112,
23,
749
]
],
[
[
1425,
25,
1264
],
[
1264,
24,
749
]
],
[
[
1425,
64,
521
],
[
521,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimavanserin"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimavanserin
Cisapride may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a mo... |
DB00348 | DB04911 | 254 | 968 | [
"DDInter1300",
"DDInter1347"
] | Nitisinone | Oritavancin | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Oritavancin is a glycopeptide antibiotic used for the treatment of skin infections. It was developed by The Medicines Company (acquired by Novartis). Oritavancin was initially approved by the FDA in 2014 and formulated to combat susceptible gram-positive bacteria that cause skin and skin structure infections. It boasts... | Moderate | 1 | [
[
[
254,
24,
968
]
],
[
[
254,
21,
28883
],
[
28883,
60,
968
]
],
[
[
254,
24,
126
],
[
126,
24,
968
]
],
[
[
254,
24,
1476
],
[
1476,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oritavancin"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Skin disorder"
],
[
"Skin disorder",
"{u} (Side Effect... | Nitisinone (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Oritavancin (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Or... |
DB00682 | DB05351 | 126 | 101 | [
"DDInter1951",
"DDInter519"
] | Warfarin | Dexlansoprazole | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
126,
24,
101
]
],
[
[
126,
25,
256
],
[
256,
62,
101
]
],
[
[
126,
23,
801
],
[
801,
62,
101
]
],
[
[
126,
25,
1479
],
[
1479,
2... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel"... | Warfarin may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Warfarin may cause a minor interaction that can limit clinical effects when taken with Brivaracetam and Brivaracetam may cause a... |
DB00008 | DB00601 | 491 | 453 | [
"DDInter1407",
"DDInter1073"
] | Peginterferon alfa-2a | Linezolid | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Moderate | 1 | [
[
[
491,
24,
453
]
],
[
[
491,
24,
770
],
[
770,
63,
453
]
],
[
[
491,
24,
10
],
[
10,
24,
453
]
],
[
[
491,
25,
1011
],
[
1011,
64,... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalid... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Linezolid
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00201 | DB00945 | 1,684 | 1,479 | [
"DDInter263",
"DDInter20"
] | Caffeine | Acetylsalicylic acid | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Minor | 0 | [
[
[
1684,
23,
1479
]
],
[
[
1684,
6,
6017
],
[
6017,
45,
1479
]
],
[
[
1684,
10,
11610
],
[
11610,
49,
1479
]
],
[
[
1684,
21,
28931
],
[
... | [
[
[
"Caffeine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Caffeine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compoun... | Caffeine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Acetylsalicylic acid (Compound)
Caffeine (Compound) palliates migraine (Disease) and migraine (Disease) is palliated by Acetylsalicylic acid (Compound)
Caffeine (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Ac... |
DB00945 | DB08822 | 1,479 | 911 | [
"DDInter20",
"DDInter156"
] | Acetylsalicylic acid | Azilsartan medoxomil | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
1479,
24,
911
]
],
[
[
1479,
63,
217
],
[
217,
1,
911
]
],
[
[
1479,
21,
29081
],
[
29081,
60,
911
]
],
[
[
1479,
24,
1220
],
[
1220,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Acetylsalicylic acid (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Azilsartan medoxomil (Compound)
Ac... |
DB00771 | DB00782 | 262 | 1,123 | [
"DDInter397",
"DDInter1535"
] | Clidinium | Propantheline | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
262,
24,
1123
]
],
[
[
262,
40,
11241
],
[
11241,
1,
1123
]
],
[
[
262,
6,
7992
],
[
7992,
45,
1123
]
],
[
[
262,
23,
359
],
[
359,
... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Clidinium",
"{u} (Compound) resembles {v} (Compound)",
"Isopropamide"
],
[
"Isopropamide",
"{u} (Compound) res... | Clidinium (Compound) resembles Isopropamide (Compound) and Isopropamide (Compound) resembles Propantheline (Compound)
Clidinium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Clidinium may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and C... |
DB00418 | DB08907 | 536 | 1,344 | [
"DDInter1650",
"DDInter280"
] | Secobarbital | Canagliflozin | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
536,
24,
1344
]
],
[
[
536,
21,
28681
],
[
28681,
60,
1344
]
],
[
[
536,
24,
1033
],
[
1033,
63,
1344
]
],
[
[
536,
24,
1486
],
[
1486... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Secobarbital",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} ... | Secobarbital (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Canagliflozin (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when... |
DB00731 | DB00827 | 1,144 | 646 | [
"DDInter1269",
"DDInter383"
] | Nateglinide | Cinoxacin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Major | 2 | [
[
[
1144,
25,
646
]
],
[
[
1144,
6,
10612
],
[
10612,
45,
646
]
],
[
[
1144,
21,
28722
],
[
28722,
60,
646
]
],
[
[
1144,
24,
1532
],
[
15... | [
[
[
"Nateglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cinoxacin"
]
],
[
[
"Nateglinide",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compound)",
"Cino... | Nateglinide (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Cinoxacin (Compound)
Nateglinide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Cinoxacin (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfam... |
DB00569 | DB00963 | 553 | 1,263 | [
"DDInter775",
"DDInter241"
] | Fondaparinux | Bromfenac | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Major | 2 | [
[
[
553,
25,
1263
]
],
[
[
553,
25,
935
],
[
935,
40,
1263
]
],
[
[
553,
64,
831
],
[
831,
40,
1263
]
],
[
[
553,
25,
1512
],
[
1512,
... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bromfenac"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ketoprofen"
],
[
"Ketoprofen",
"{u... | Fondaparinux may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Fondaparinux may lead to a major life threatening interaction when taken with Indomethacin and Indomethacin (Compound) resembles Bromfenac (Compound)
Fondaparinux may lead to... |
DB00373 | DB00374 | 461 | 1,061 | [
"DDInter1809",
"DDInter1852"
] | Timolol | Treprostinil | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Moderate | 1 | [
[
[
461,
24,
1061
]
],
[
[
461,
24,
885
],
[
885,
40,
1061
]
],
[
[
461,
18,
8109
],
[
8109,
57,
1061
]
],
[
[
461,
6,
3576
],
[
3576,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Timolol (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Treprostinil (Compound)
Timolol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene)... |
DB08820 | DB11967 | 1,478 | 710 | [
"DDInter997",
"DDInter210"
] | Ivacaftor | Binimetinib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
1478,
24,
710
]
],
[
[
1478,
64,
441
],
[
441,
24,
710
]
],
[
[
1478,
25,
1593
],
[
1593,
24,
710
]
],
[
[
1478,
25,
68
],
[
68,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Ivacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delavirdine"
],
[
"Delavirdin... | Ivacaftor may lead to a major life threatening interaction when taken with Delavirdine and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Ivacaftor may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate int... |
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