drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01218 | DB06414 | 1,493 | 655 | [
"DDInter852",
"DDInter703"
] | Halofantrine | Etravirine | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1493,
24,
655
]
],
[
[
1493,
25,
786
],
[
786,
40,
655
]
],
[
[
1493,
6,
8374
],
[
8374,
45,
655
]
],
[
[
1493,
21,
28680
],
[
28680,
... | [
[
[
"Halofantrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilpivirine"
],
[
"Rilpi... | Halofantrine may lead to a major life threatening interaction when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Halofantrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etravirine (Compound)
Halofantrine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is... |
DB04953 | DB09472 | 495 | 1,383 | [
"DDInter708",
"DDInter1693"
] | Ezogabine | Sodium sulfate | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
495,
24,
1383
]
],
[
[
495,
63,
609
],
[
609,
24,
1383
]
],
[
[
495,
24,
1342
],
[
1342,
24,
1383
]
],
[
[
495,
25,
1618
],
[
1618,
... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin ... |
DB00209 | DB01227 | 352 | 1,301 | [
"DDInter1886",
"DDInter1043"
] | Trospium | Levacetylmethadol | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Moderate | 1 | [
[
[
352,
24,
1301
]
],
[
[
352,
24,
494
],
[
494,
1,
1301
]
],
[
[
352,
40,
11264
],
[
11264,
1,
1301
]
],
[
[
352,
24,
1511
],
[
1511,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Trospium (Compound) resembles Diphenidol (Compound) and Diphenidol (Compound) resembles Levacetylmethadol (Compound)
Trospium may cause a moderate inte... |
DB00607 | DB01211 | 1,249 | 609 | [
"DDInter1256",
"DDInter393"
] | Nafcillin | Clarithromycin | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Minor | 0 | [
[
[
1249,
23,
609
]
],
[
[
1249,
6,
8374
],
[
8374,
45,
609
]
],
[
[
1249,
18,
4360
],
[
4360,
57,
609
]
],
[
[
1249,
21,
28664
],
[
28664... | [
[
[
"Nafcillin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
]
],
[
[
"Nafcillin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Nafcillin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Nafcillin (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Clarithromycin (Compound)
Nafcillin (Compound) causes Tongue discolouration (Side Effect) and Tongue discolouration (Side Effect) is cause... |
DB00106 | DB01165 | 618 | 1,539 | [
"DDInter4",
"DDInter1325"
] | Abarelix | Ofloxacin | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
618,
24,
1539
]
],
[
[
618,
25,
1176
],
[
1176,
1,
1539
]
],
[
[
618,
24,
956
],
[
956,
40,
1539
]
],
[
[
618,
23,
112
],
[
112,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxifloxacin"... | Abarelix may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin (Compound) resembles Ofloxacin (Compound)
Abarelix may ca... |
DB00363 | DB13928 | 695 | 1,385 | [
"DDInter419",
"DDInter1660"
] | Clozapine | Semaglutide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
695,
24,
1385
]
],
[
[
695,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
695,
24,
1144
],
[
1144,
24,
1385
]
],
[
[
695,
64,
305
],
[
305,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
"Pasireotid... | Clozapine may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cau... |
DB00400 | DB00402 | 353 | 1,407 | [
"DDInter843",
"DDInter685"
] | Griseofulvin | Eszopiclone | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Moderate | 1 | [
[
[
353,
24,
1407
]
],
[
[
353,
6,
8374
],
[
8374,
45,
1407
]
],
[
[
353,
21,
28680
],
[
28680,
60,
1407
]
],
[
[
353,
62,
1101
],
[
1101,... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eszopiclone"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Eszopiclone (Compound)
Griseofulvin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Eszopiclone (Compound)
Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarote... |
DB00451 | DB01309 | 542 | 1,254 | [
"DDInter1064",
"DDInter933"
] | Levothyroxine | Insulin glulisine | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
542,
24,
1254
]
],
[
[
542,
24,
280
],
[
280,
63,
1254
]
],
[
[
542,
63,
1645
],
[
1645,
24,
1254
]
],
[
[
542,
23,
887
],
[
887,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephentermine"... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Mephentermine and Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Me... |
DB01501 | DB04953 | 1,118 | 495 | [
"DDInter549",
"DDInter708"
] | Difenoxin | Ezogabine | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
1118,
24,
495
]
],
[
[
1118,
40,
543
],
[
543,
24,
495
]
],
[
[
1118,
63,
530
],
[
530,
24,
495
]
],
[
[
1118,
24,
1609
],
[
1609,
... | [
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Difenoxin",
"{u} (Compound) resembles {v} (Compound)",
"Loperamide"
],
[
"Loperamide",
"{u} may cause a moderate i... | Difenoxin (Compound) resembles Loperamide (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Ezogabine
Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could ex... |
DB00775 | DB15035 | 1,226 | 503 | [
"DDInter1818",
"DDInter1959"
] | Tirofiban | Zanubrutinib | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1226,
25,
503
]
],
[
[
1226,
24,
222
],
[
222,
24,
503
]
],
[
[
1226,
63,
121
],
[
121,
24,
503
]
],
[
[
1226,
25,
39
],
[
39,
2... | [
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fe... |
DB00603 | DB08886 | 303 | 637 | [
"DDInter1137",
"DDInter126"
] | Medroxyprogesterone acetate | Asparaginase Erwinia chrysanthemi | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
303,
24,
637
]
],
[
[
303,
64,
640
],
[
640,
24,
637
]
],
[
[
303,
24,
392
],
[
392,
24,
637
]
],
[
[
303,
40,
167
],
[
167,
24,... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken wit... | Medroxyprogesterone acetate may lead to a major life threatening interaction when taken with Acitretin and Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseas... |
DB00683 | DB09293 | 1,382 | 116 | [
"DDInter1212",
"DDInter954"
] | Midazolam | Iodide I-131 | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1382,
24,
116
]
],
[
[
1382,
23,
1486
],
[
1486,
24,
116
]
],
[
[
1382,
63,
701
],
[
701,
24,
116
]
],
[
[
1382,
24,
516
],
[
516,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Midazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methylprednisolone"
],
... | Midazolam may cause a minor interaction that can limit clinical effects when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Clemast... |
DB08865 | DB08916 | 1,593 | 26 | [
"DDInter448",
"DDInter32"
] | Crizotinib | Afatinib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
1593,
24,
26
]
],
[
[
1593,
63,
883
],
[
883,
40,
26
]
],
[
[
1593,
6,
4973
],
[
4973,
45,
26
]
],
[
[
1593,
34,
2030
],
[
2030,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Crizotinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Crizotinib (Compound) binds ABL1 (Gene) and Crizotinib (Compound) upregula... |
DB00014 | DB00193 | 521 | 534 | [
"DDInter839",
"DDInter1841"
] | Goserelin | Tramadol | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Moderate | 1 | [
[
[
521,
24,
534
]
],
[
[
521,
24,
1100
],
[
1100,
40,
534
]
],
[
[
521,
21,
28987
],
[
28987,
60,
534
]
],
[
[
521,
23,
112
],
[
112,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tramadol"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Tramadol (Compound)
Goserelin (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Tramadol (Compound)
Goserelin may cause a minor interaction that can limit... |
DB00427 | DB00697 | 1,233 | 876 | [
"DDInter1879",
"DDInter1821"
] | Triprolidine | Tizanidine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
1233,
24,
876
]
],
[
[
1233,
24,
1617
],
[
1617,
1,
876
]
],
[
[
1233,
24,
401
],
[
401,
63,
876
]
],
[
[
1233,
63,
19
],
[
19,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Tizanidine (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interact... |
DB06704 | DB11003 | 247 | 748 | [
"DDInter952",
"DDInter100"
] | Iobenguane (I-131) | Anthrax vaccine | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
247,
24,
748
]
],
[
[
247,
7,
6952
],
[
6952,
46,
77
],
[
77,
24,
748
]
],
[
[
247,
18,
7359
],
[
7359,
57,
147
],
[
147,
24,
... | [
[
[
"Iobenguane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Iobenguane",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
"{u} (Gene) is upregulated by... | Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Iobenguane (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vacc... |
DB00013 | DB01088 | 1,255 | 714 | [
"DDInter1905",
"DDInter908"
] | Urokinase | Iloprost | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1255,
24,
714
]
],
[
[
1255,
23,
539
],
[
539,
62,
714
]
],
[
[
1255,
24,
1638
],
[
1638,
24,
714
]
],
[
[
1255,
25,
1432
],
[
1432,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Urokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Cap... | Urokinase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Iloprost
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril may... |
DB00218 | DB01259 | 1,176 | 392 | [
"DDInter1247",
"DDInter1024"
] | Moxifloxacin | Lapatinib | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
1176,
25,
392
]
],
[
[
1176,
21,
29429
],
[
29429,
60,
392
]
],
[
[
1176,
23,
112
],
[
112,
23,
392
]
],
[
[
1176,
25,
918
],
[
918,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Infestation NOS"
],
[
"Infestation NOS",
"{u} (Side Effect) is caus... | Moxifloxacin (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when t... |
DB01033 | DB11003 | 328 | 748 | [
"DDInter1156",
"DDInter100"
] | Mercaptopurine | Anthrax vaccine | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
328,
24,
748
]
],
[
[
328,
63,
322
],
[
322,
24,
748
]
],
[
[
328,
25,
676
],
[
676,
63,
748
]
],
[
[
328,
24,
1683
],
[
1683,
2... | [
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
... | Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Mercaptopurine may lead to a major life threatening interaction when taken with Upadacitinib and Upadac... |
DB00065 | DB13007 | 581 | 1,060 | [
"DDInter923",
"DDInter642"
] | Infliximab | Enfortumab vedotin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Major | 2 | [
[
[
581,
25,
1060
]
],
[
[
581,
24,
1593
],
[
1593,
24,
1060
]
],
[
[
581,
25,
270
],
[
270,
24,
1060
]
],
[
[
581,
63,
268
],
[
268,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[
"Cr... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Infliximab may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab ... |
DB06700 | DB09082 | 643 | 659 | [
"DDInter511",
"DDInter1934"
] | Desvenlafaxine | Vilanterol | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
643,
24,
659
]
],
[
[
643,
64,
222
],
[
222,
24,
659
]
],
[
[
643,
63,
702
],
[
702,
24,
659
]
],
[
[
643,
24,
1618
],
[
1618,
2... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Desvenlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"S... | Desvenlafaxine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide and Anagrelide ... |
DB00978 | DB01181 | 739 | 1,532 | [
"DDInter1084",
"DDInter906"
] | Lomefloxacin | Ifosfamide | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Minor | 0 | [
[
[
739,
23,
1532
]
],
[
[
739,
21,
29209
],
[
29209,
60,
1532
]
],
[
[
739,
40,
1299
],
[
1299,
23,
1532
]
],
[
[
739,
1,
1467
],
[
1467,... | [
[
[
"Lomefloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ifosfamide"
]
],
[
[
"Lomefloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Effect) is caus... | Lomefloxacin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Lomefloxacin (Compound) resembles Trovafloxacin (Compound) and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Ifosfamide
Lomefloxacin (Compound) resembles Enox... |
DB00741 | DB01170 | 167 | 1,150 | [
"DDInter885",
"DDInter846"
] | Hydrocortisone | Guanethidine | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Moderate | 1 | [
[
[
167,
24,
1150
]
],
[
[
167,
6,
8374
],
[
8374,
45,
1150
]
],
[
[
167,
24,
1344
],
[
1344,
63,
1150
]
],
[
[
167,
1,
617
],
[
617,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanethidine"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Hydrocortisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Guanethidine (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Guanethidine
... |
DB00434 | DB01121 | 13 | 94 | [
"DDInter459",
"DDInter1437"
] | Cyproheptadine | Phenacemide | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. | Moderate | 1 | [
[
[
13,
24,
94
]
],
[
[
13,
24,
551
],
[
551,
1,
94
]
],
[
[
13,
24,
1614
],
[
1614,
24,
94
]
],
[
[
13,
24,
1264
],
[
1264,
63,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Phenacemide (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that ... |
DB00250 | DB00609 | 10 | 595 | [
"DDInter475",
"DDInter694"
] | Dapsone | Ethionamide | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Moderate | 1 | [
[
[
10,
24,
595
]
],
[
[
10,
21,
28900
],
[
28900,
60,
595
]
],
[
[
10,
63,
1057
],
[
1057,
24,
595
]
],
[
[
10,
24,
1662
],
[
1662,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethionamide"
]
],
[
[
"Dapsone",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is... | Dapsone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Ethionamide (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Et... |
DB00065 | DB12498 | 581 | 76 | [
"DDInter923",
"DDInter1238"
] | Infliximab | Mogamulizumab | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Major | 2 | [
[
[
581,
25,
76
]
],
[
[
581,
23,
1461
],
[
1461,
23,
76
]
],
[
[
581,
25,
1531
],
[
1531,
24,
76
]
],
[
[
581,
24,
496
],
[
496,
24... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Infliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Infliximab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab
Infliximab may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a... |
DB00379 | DB09036 | 143 | 812 | [
"DDInter1206",
"DDInter1668"
] | Mexiletine | Siltuximab | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
143,
24,
812
]
],
[
[
143,
64,
1031
],
[
1031,
24,
812
]
],
[
[
143,
63,
608
],
[
608,
24,
812
]
],
[
[
143,
24,
259
],
[
259,
2... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Mexiletine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Theophylline"
],
[
"Theophyl... | Mexiletine may lead to a major life threatening interaction when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab
Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may caus... |
DB00046 | DB00620 | 1,179 | 175 | [
"DDInter940",
"DDInter1855"
] | Insulin lispro | Triamcinolone | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
1179,
24,
175
]
],
[
[
1179,
24,
1573
],
[
1573,
1,
175
]
],
[
[
1179,
24,
155
],
[
155,
63,
175
]
],
[
[
1179,
23,
1103
],
[
1103,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone may cause a moderate i... |
DB01396 | DB08865 | 1,482 | 1,593 | [
"DDInter553",
"DDInter448"
] | Digitoxin | Crizotinib | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
1482,
24,
1593
]
],
[
[
1482,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1482,
7,
5295
],
[
5295,
45,
1593
]
],
[
[
1482,
18,
2035
],
[
2035... | [
[
[
"Digitoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Digitoxin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Digitoxin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Digitoxin (Compound) upregulates CDK7 (Gene) and CDK7 (Gene) is bound by Crizotinib (Compound)
Digitoxin (Compound) downregulates IRAK1 (Gene) and IRAK1 (Gene) is bound by Crizotinib (Compound)
Digitoxin (Compound) upregulates ... |
DB00679 | DB01176 | 684 | 537 | [
"DDInter1796",
"DDInter453"
] | Thioridazine | Cyclizine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
684,
24,
537
]
],
[
[
684,
24,
1511
],
[
1511,
63,
537
]
],
[
[
684,
63,
1242
],
[
1242,
24,
537
]
],
[
[
684,
36,
104
],
[
104,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and C... |
DB01023 | DB01069 | 409 | 401 | [
"DDInter716",
"DDInter1533"
] | Felodipine | Promethazine | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
409,
24,
401
]
],
[
[
409,
24,
820
],
[
820,
63,
401
]
],
[
[
409,
63,
104
],
[
104,
24,
401
]
],
[
[
409,
6,
1977
],
[
1977,
45... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[... | Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and ... |
DB00757 | DB00999 | 1,166 | 504 | [
"DDInter581",
"DDInter883"
] | Dolasetron | Hydrochlorothiazide | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Major | 2 | [
[
[
1166,
25,
504
]
],
[
[
1166,
25,
178
],
[
178,
1,
504
]
],
[
[
1166,
64,
323
],
[
323,
40,
504
]
],
[
[
1166,
25,
359
],
[
359,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Polythiazide"
],
[
"Polythiazide",... | Dolasetron may lead to a major life threatening interaction when taken with Polythiazide and Polythiazide (Compound) resembles Hydrochlorothiazide (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Bendroflumethiazide and Bendroflumethiazide (Compound) resembles Hydrochlorothiazide (... |
DB00327 | DB11130 | 421 | 407 | [
"DDInter890",
"DDInter1344"
] | Hydromorphone | Opium | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
421,
24,
407
]
],
[
[
421,
24,
662
],
[
662,
24,
407
]
],
[
[
421,
63,
352
],
[
352,
24,
407
]
],
[
[
421,
64,
475
],
[
475,
24,... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Trospium and T... |
DB00582 | DB00712 | 1,622 | 1,274 | [
"DDInter1946",
"DDInter763"
] | Voriconazole | Flurbiprofen | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
1622,
24,
1274
]
],
[
[
1622,
6,
10522
],
[
10522,
45,
1274
]
],
[
[
1622,
21,
28769
],
[
28769,
60,
1274
]
],
[
[
1622,
24,
1559
],
[
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"PTGS1"
],
[
"PTGS1",
"{u} (Gene) is bound by {v} (Compoun... | Voriconazole (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Flurbiprofen (Compound)
Voriconazole (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00609 | DB01229 | 595 | 973 | [
"DDInter694",
"DDInter1378"
] | Ethionamide | Paclitaxel (protein-bound) | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
595,
24,
973
]
],
[
[
595,
24,
310
],
[
310,
63,
973
]
],
[
[
595,
18,
5527
],
[
5527,
57,
973
]
],
[
[
595,
21,
28827
],
[
28827,
... | [
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Ethion... |
DB00224 | DB01229 | 215 | 973 | [
"DDInter917",
"DDInter1377"
] | Indinavir | Paclitaxel | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Major | 2 | [
[
[
215,
25,
973
]
],
[
[
215,
24,
310
],
[
310,
63,
973
]
],
[
[
215,
6,
7524
],
[
7524,
45,
973
]
],
[
[
215,
7,
4786
],
[
4786,
4... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitaxel... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Indinavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Indinavir (Compoun... |
DB11796 | DB12130 | 1,612 | 1,017 | [
"DDInter786",
"DDInter1094"
] | Fostemsavir | Lorlatinib | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Minor | 0 | [
[
[
1612,
23,
1017
]
],
[
[
1612,
62,
1101
],
[
1101,
23,
1017
]
],
[
[
1612,
63,
14
],
[
14,
24,
1017
]
],
[
[
1612,
64,
11
],
[
11,
... | [
[
[
"Fostemsavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lorlatinib"
]
],
[
[
"Fostemsavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Fostemsavir may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuva... |
DB00279 | DB00960 | 1,152 | 887 | [
"DDInter1074",
"DDInter1471"
] | Liothyronine | Pindolol | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Minor | 0 | [
[
[
1152,
23,
887
]
],
[
[
1152,
23,
819
],
[
819,
40,
887
]
],
[
[
1152,
62,
88
],
[
88,
40,
887
]
],
[
[
1152,
23,
1121
],
[
1121,
... | [
[
[
"Liothyronine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pindolol"
]
],
[
[
"Liothyronine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acebutolol"
],
[
... | Liothyronine may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Liothyronine may cause a minor interaction that can limit clinical effects when taken with Metoprolol and Metoprolol (Compound) resembles Pindolol (Compound)
Liot... |
DB01211 | DB09074 | 609 | 1,362 | [
"DDInter393",
"DDInter1327"
] | Clarithromycin | Olaparib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
609,
25,
1362
]
],
[
[
609,
24,
627
],
[
627,
63,
1362
]
],
[
[
609,
64,
576
],
[
576,
24,
1362
]
],
[
[
609,
62,
139
],
[
139,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
],
[
"Bic... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir and Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Clarithromycin may lead to a major life threatening interaction when taken with Methadone and Methadone may ... |
DB00945 | DB11689 | 1,479 | 321 | [
"DDInter20",
"DDInter1659"
] | Acetylsalicylic acid | Selumetinib | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Moderate | 1 | [
[
[
1479,
24,
321
]
],
[
[
1479,
63,
291
],
[
291,
24,
321
]
],
[
[
1479,
25,
498
],
[
498,
24,
321
]
],
[
[
1479,
25,
1421
],
[
1421,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selumetinib"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Argatr... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Argatroban and Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Acetylsalicylic acid may lead to a major life threatening interaction when taken with Edoxaban and Ed... |
DB00186 | DB09104 | 905 | 286 | [
"DDInter1092",
"DDInter1118"
] | Lorazepam | Magnesium hydroxide | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
905,
23,
286
]
],
[
[
905,
40,
481
],
[
481,
23,
286
]
],
[
[
905,
24,
820
],
[
820,
23,
286
]
],
[
[
905,
23,
1283
],
[
1283,
2... | [
[
[
"Lorazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Lorazepam",
"{u} (Compound) resembles {v} (Compound)",
"Quazepam"
],
[
"Quazepam",
"{u} may cause a minor ... | Lorazepam (Compound) resembles Quazepam (Compound) and Quazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Lorazepam may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can l... |
DB00284 | DB01232 | 1,647 | 1,327 | [
"DDInter11",
"DDInter1640"
] | Acarbose | Saquinavir | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
1647,
24,
1327
]
],
[
[
1647,
24,
833
],
[
833,
1,
1327
]
],
[
[
1647,
63,
798
],
[
798,
40,
1327
]
],
[
[
1647,
24,
915
],
[
915,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
],
[
"... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Lopinavir and Lopinavir (Compound) resembles Saquinavir (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Acarbo... |
DB00533 | DB00704 | 1,416 | 267 | [
"DDInter1613",
"DDInter1263"
] | Rofecoxib | Naltrexone | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
1416,
24,
267
]
],
[
[
1416,
24,
850
],
[
850,
63,
267
]
],
[
[
1416,
24,
1512
],
[
1512,
24,
267
]
],
[
[
1416,
63,
912
],
[
912,
... | [
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
],
... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Diclo... |
DB00450 | DB04837 | 78 | 649 | [
"DDInter603",
"DDInter407"
] | Droperidol | Clofedanol | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
78,
24,
649
]
],
[
[
78,
24,
1376
],
[
1376,
24,
649
]
],
[
[
78,
24,
832
],
[
832,
40,
649
]
],
[
[
78,
63,
701
],
[
701,
24,
... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Tripelennam... |
DB06605 | DB06636 | 1,409 | 1,623 | [
"DDInter108",
"DDInter980"
] | Apixaban | Isavuconazonium | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1409,
24,
1623
]
],
[
[
1409,
63,
222
],
[
222,
23,
1623
]
],
[
[
1409,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
1409,
64,
1213
],
[
1213... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Isavuconazonium
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatini... |
DB01136 | DB08884 | 772 | 796 | [
"DDInter305",
"DDInter800"
] | Carvedilol | Gadoxetic acid | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up ... | Moderate | 1 | [
[
[
772,
24,
796
]
],
[
[
772,
63,
457
],
[
457,
1,
796
]
],
[
[
772,
24,
1106
],
[
1106,
1,
796
]
],
[
[
772,
21,
28841
],
[
28841,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoxetic acid"
]
],
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadodiamide"
],
... | Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Gadodiamide and Gadodiamide (Compound) resembles Gadoxetic acid (Compound)
Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Gadofosveset trisodium and Gadofosveset trisodium (Compound) re... |
DB00713 | DB01211 | 1,138 | 609 | [
"DDInter1354",
"DDInter393"
] | Oxacillin | Clarithromycin | An antibiotic similar to [flucloxacillin] used in resistant staphylococci infections. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Minor | 0 | [
[
[
1138,
23,
609
]
],
[
[
1138,
18,
3106
],
[
3106,
57,
609
]
],
[
[
1138,
21,
28664
],
[
28664,
60,
609
]
],
[
[
1138,
40,
319
],
[
319,... | [
[
[
"Oxacillin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
]
],
[
[
"Oxacillin",
"{u} (Compound) downregulates {v} (Gene)",
"DNAJA3"
],
[
"DNAJA3",
"{u} (Gene) is downregulated by ... | Oxacillin (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Clarithromycin (Compound)
Oxacillin (Compound) causes Tongue discolouration (Side Effect) and Tongue discolouration (Side Effect) is caused by Clarithromycin (Compound)
Oxacillin (Compound) resembles Amoxicillin (Compound) and Amoxic... |
DB01276 | DB01324 | 123 | 178 | [
"DDInter706",
"DDInter1490"
] | Exenatide | Polythiazide | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
123,
24,
178
]
],
[
[
123,
63,
674
],
[
674,
40,
178
]
],
[
[
123,
63,
126
],
[
126,
23,
178
]
],
[
[
123,
63,
848
],
[
848,
24,... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
],
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction t... |
DB00261 | DB00845 | 702 | 1,490 | [
"DDInter93",
"DDInter406"
] | Anagrelide | Clofazimine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Major | 2 | [
[
[
702,
25,
1490
]
],
[
[
702,
21,
28787
],
[
28787,
60,
1490
]
],
[
[
702,
23,
112
],
[
112,
62,
1490
]
],
[
[
702,
25,
1250
],
[
1250,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clofazimine"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused by {v} (C... | Anagrelide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Clofazimine (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cl... |
DB00365 | DB01101 | 839 | 60 | [
"DDInter842",
"DDInter285"
] | Grepafloxacin | Capecitabine | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Minor | 0 | [
[
[
839,
23,
60
]
],
[
[
839,
24,
309
],
[
309,
62,
60
]
],
[
[
839,
24,
147
],
[
147,
23,
60
]
],
[
[
839,
23,
112
],
[
112,
24,
... | [
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capecitabine"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a minor interaction that can limit clinical effects when taken with Capecitabine
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine a... |
DB00404 | DB09054 | 523 | 384 | [
"DDInter54",
"DDInter905"
] | Alprazolam | Idelalisib | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
523,
24,
384
]
],
[
[
523,
24,
222
],
[
222,
23,
384
]
],
[
[
523,
1,
1565
],
[
1565,
24,
384
]
],
[
[
523,
63,
58
],
[
58,
24,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Alprazolam (Compound) resembles Clonazepam (Compound) and Clonazepam may cause a moderate interaction that could... |
DB05676 | DB12267 | 1,513 | 1,476 | [
"DDInter111",
"DDInter233"
] | Apremilast | Brigatinib | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1513,
24,
1476
]
],
[
[
1513,
24,
1598
],
[
1598,
63,
1476
]
],
[
[
1513,
63,
804
],
[
804,
24,
1476
]
],
[
[
1513,
24,
124
],
[
124,
... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat and Tazemetostat may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone an... |
DB12141 | DB14575 | 971 | 733 | [
"DDInter817",
"DDInter674"
] | Gilteritinib | Eslicarbazepine | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
971,
24,
733
]
],
[
[
971,
64,
1101
],
[
1101,
23,
733
]
],
[
[
971,
63,
1264
],
[
1264,
24,
733
]
],
[
[
971,
62,
1135
],
[
1135,
... | [
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Gilteritinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"B... | Gilteritinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause... |
DB00902 | DB09118 | 104 | 1,580 | [
"DDInter1168",
"DDInter1711"
] | Methdilazine | Stiripentol | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
104,
24,
1580
]
],
[
[
104,
24,
1532
],
[
1532,
24,
1580
]
],
[
[
104,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
104,
40,
820
],
[
820,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine an... |
DB00631 | DB08932 | 372 | 1,398 | [
"DDInter405",
"DDInter1111"
] | Clofarabine | Macitentan | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Moderate | 1 | [
[
[
372,
24,
1398
]
],
[
[
372,
21,
29429
],
[
29429,
60,
1398
]
],
[
[
372,
24,
283
],
[
283,
63,
1398
]
],
[
[
372,
24,
1478
],
[
1478,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macitentan"
]
],
[
[
"Clofarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Infestation NOS"
],
[
"Infestation NOS",
"{u} (Side E... | Clofarabine (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Macitentan (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when take... |
DB00275 | DB13620 | 217 | 948 | [
"DDInter1330",
"DDInter1499"
] | Olmesartan | Potassium gluconate | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Major | 2 | [
[
[
217,
25,
948
]
],
[
[
217,
63,
176
],
[
176,
23,
948
]
],
[
[
217,
24,
1254
],
[
1254,
23,
948
]
],
[
[
217,
24,
848
],
[
848,
2... | [
[
[
"Olmesartan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
],
[
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Potassium gluconate
Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with In... |
DB00327 | DB00572 | 421 | 85 | [
"DDInter890",
"DDInter136"
] | Hydromorphone | Atropine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
421,
24,
85
]
],
[
[
421,
24,
19
],
[
19,
24,
85
]
],
[
[
421,
24,
1166
],
[
1166,
40,
85
]
],
[
[
421,
21,
28719
],
[
28719,
60... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Dolasetron and ... |
DB00420 | DB09481 | 508 | 460 | [
"DDInter1532",
"DDInter1113"
] | Promazine | Magnesium carbonate | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
508,
23,
460
]
],
[
[
508,
35,
401
],
[
401,
23,
460
]
],
[
[
508,
24,
355
],
[
355,
23,
460
]
],
[
[
508,
40,
216
],
[
216,
23,... | [
[
[
"Promazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Promazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when ta... | Promazine (Compound) resembles Promethazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Promazine may cause a moderate interaction ... |
DB00196 | DB00624 | 600 | 1,561 | [
"DDInter743",
"DDInter1775"
] | Fluconazole | Testosterone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Moderate | 1 | [
[
[
600,
24,
1561
]
],
[
[
600,
24,
1438
],
[
1438,
1,
1561
]
],
[
[
600,
24,
870
],
[
870,
63,
1561
]
],
[
[
600,
25,
312
],
[
312,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Testosterone (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interactio... |
DB00195 | DB08946 | 726 | 512 | [
"DDInter198",
"DDInter962"
] | Betaxolol (ophthalmic) | Iopanoic acid | Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment... | Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. | Moderate | 1 | [
[
[
726,
24,
512
]
],
[
[
726,
24,
1106
],
[
1106,
24,
512
]
],
[
[
726,
1,
819
],
[
819,
24,
512
]
],
[
[
726,
24,
777
],
[
777,
63... | [
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopanoic acid"
]
],
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadofosveset trisodium"
... | Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Iopanoic acid
Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Gadofosveset trisodium and Gadofosveset trisodium may cause a moderate interaction that could exacerbate diseases when taken w... |
DB08899 | DB13879 | 129 | 1,043 | [
"DDInter649",
"DDInter824"
] | Enzalutamide | Glecaprevir | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with , glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic ba... | Moderate | 1 | [
[
[
129,
24,
1043
]
],
[
[
129,
25,
1135
],
[
1135,
23,
1043
]
],
[
[
129,
63,
353
],
[
353,
24,
1043
]
],
[
[
129,
25,
466
],
[
466,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glecaprevir"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxe... | Enzalutamide may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glecaprevir
Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may c... |
DB01045 | DB01254 | 463 | 1,213 | [
"DDInter1590",
"DDInter484"
] | Rifampicin | Dasatinib | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
463,
25,
1213
]
],
[
[
463,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
463,
6,
8155
],
[
8155,
46,
1213
]
],
[
[
463,
63,
112
],
[
112,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Rifampicin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatinib"... | Rifampicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Rifampicin (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Dasatinib (Compound)
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause... |
DB00557 | DB05381 | 252 | 172 | [
"DDInter895",
"DDInter863"
] | Hydroxyzine | Histamine | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Moderate | 1 | [
[
[
252,
24,
172
]
],
[
[
252,
24,
1264
],
[
1264,
24,
172
]
],
[
[
252,
74,
1242
],
[
1242,
24,
172
]
],
[
[
252,
63,
13
],
[
13,
2... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histamine"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Histamine
Hydroxyzine (Compound) resembles Cetirizine (Compound) and Hydroxyzine may cause a moderate interaction that could exa... |
DB00570 | DB06273 | 147 | 980 | [
"DDInter1936",
"DDInter1824"
] | Vinblastine | Tocilizumab | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
147,
24,
980
]
],
[
[
147,
63,
1461
],
[
1461,
23,
980
]
],
[
[
147,
63,
139
],
[
139,
24,
980
]
],
[
[
147,
24,
309
],
[
309,
2... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tocilizumab
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovud... |
DB05773 | DB06603 | 1,047 | 39 | [
"DDInter1848",
"DDInter1387"
] | Trastuzumab emtansine | Panobinostat | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1047,
25,
39
]
],
[
[
1047,
63,
112
],
[
112,
23,
39
]
],
[
[
1047,
63,
912
],
[
912,
24,
39
]
],
[
[
1047,
24,
282
],
[
282,
63... | [
[
[
"Trastuzumab emtansine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when take... |
DB00475 | DB00651 | 1,119 | 746 | [
"DDInter355",
"DDInter613"
] | Chlordiazepoxide | Dyphylline | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Minor | 0 | [
[
[
1119,
23,
746
]
],
[
[
1119,
62,
1031
],
[
1031,
1,
746
]
],
[
[
1119,
1,
902
],
[
902,
23,
746
]
],
[
[
1119,
1,
1418
],
[
1418,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dyphylline"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Theophylline"
]... | Chlordiazepoxide may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline (Compound) resembles Dyphylline (Compound)
Chlordiazepoxide (Compound) resembles Clobazam (Compound) and Clobazam may cause a minor interaction that can limit clinical effects when taken with Dyp... |
DB00261 | DB11057 | 702 | 720 | [
"DDInter93",
"DDInter1223"
] | Anagrelide | Mineral oil | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
702,
24,
720
]
],
[
[
702,
25,
927
],
[
927,
63,
720
]
],
[
[
702,
25,
1151
],
[
1151,
24,
720
]
],
[
[
702,
24,
898
],
[
898,
2... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafe... | Anagrelide may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Anagrelide may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a moderate int... |
DB00563 | DB08903 | 663 | 996 | [
"DDInter1174",
"DDInter170"
] | Methotrexate | Bedaquiline | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
663,
24,
996
]
],
[
[
663,
21,
29402
],
[
29402,
60,
996
]
],
[
[
663,
24,
713
],
[
713,
63,
996
]
],
[
[
663,
25,
848
],
[
848,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Methotrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Hepatobiliary disease"
],
[
"Hepatobiliary disease",
... | Methotrexate (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Bedaquiline (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could ... |
DB00701 | DB01222 | 1,091 | 617 | [
"DDInter90",
"DDInter246"
] | Amprenavir | Budesonide | Amprenavir is a protease inhibitor used to treat HIV infection. | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Major | 2 | [
[
[
1091,
25,
617
]
],
[
[
1091,
63,
1351
],
[
1351,
1,
617
]
],
[
[
1091,
64,
175
],
[
175,
1,
617
]
],
[
[
1091,
24,
1220
],
[
1220,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flunisolide"
],
[
"Flunisoli... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Budesonide (Compound)
Amprenavir may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Budesonide (Compound)
Amprena... |
DB00460 | DB08916 | 612 | 26 | [
"DDInter1929",
"DDInter32"
] | Verteporfin | Afatinib | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
612,
24,
26
]
],
[
[
612,
63,
883
],
[
883,
40,
26
]
],
[
[
612,
21,
28723
],
[
28723,
60,
26
]
],
[
[
612,
24,
663
],
[
663,
24... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Verteporfin (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Afatinib (Compound)
Verteporfin may cause a moderate interacti... |
DB11560 | DB12015 | 1,678 | 1,033 | [
"DDInter1038",
"DDInter53"
] | Lesinurad | Alpelisib | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1678,
24,
1033
]
],
[
[
1678,
63,
1144
],
[
1144,
24,
1033
]
],
[
[
1678,
24,
351
],
[
351,
24,
1033
]
],
[
[
1678,
24,
1619
],
[
1619... | [
[
[
"Lesinurad",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Lesinurad",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
... | Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribocic... |
DB00850 | DB09564 | 1,630 | 1,296 | [
"DDInter1432",
"DDInter930"
] | Perphenazine | Insulin degludec | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1630,
24,
1296
]
],
[
[
1630,
63,
274
],
[
274,
23,
1296
]
],
[
[
1630,
64,
1621
],
[
1621,
23,
1296
]
],
[
[
1630,
24,
1411
],
[
1411... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Perphenazine may lead to a major life threatening interaction when taken with Potassium chloride and P... |
DB00549 | DB00682 | 522 | 126 | [
"DDInter1955",
"DDInter1951"
] | Zafirlukast | Warfarin | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
522,
24,
126
]
],
[
[
522,
6,
3486
],
[
3486,
45,
126
]
],
[
[
522,
63,
168
],
[
168,
23,
126
]
],
[
[
522,
24,
671
],
[
671,
62... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",... | Zafirlukast (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Warfarin (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Warfarin
Zafirlukast may cause ... |
DB08879 | DB10583 | 632 | 949 | [
"DDInter173",
"DDInter415"
] | Belimumab | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
632,
24,
949
]
],
[
[
632,
64,
1377
],
[
1377,
24,
949
]
],
[
[
632,
63,
58
],
[
58,
24,
949
]
],
[
[
632,
25,
1259
],
[
1259,
6... | [
[
[
"Belimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Belimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Belimumab may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Belimumab may cause a moderate interaction that could exacerbate diseases wh... |
DB00312 | DB00990 | 1,023 | 1,547 | [
"DDInter1423",
"DDInter705"
] | Pentobarbital | Exemestane | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Moderate | 1 | [
[
[
1023,
24,
1547
]
],
[
[
1023,
24,
891
],
[
891,
40,
1547
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
1547
]
],
[
[
1023,
21,
28787
],
[
2878... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exemestane"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone (Compound) resembles Exemestane (Compound)
Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Exemestane (Compound)
Pentobarbital (Compound) causes Dermatitis (Side Effect)... |
DB00836 | DB12825 | 543 | 1,375 | [
"DDInter1088",
"DDInter1032"
] | Loperamide | Lefamulin | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
543,
24,
1375
]
],
[
[
543,
24,
112
],
[
112,
23,
1375
]
],
[
[
543,
24,
1320
],
[
1320,
24,
1375
]
],
[
[
543,
64,
752
],
[
752,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elago... |
DB00106 | DB08871 | 618 | 36 | [
"DDInter4",
"DDInter666"
] | Abarelix | Eribulin | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
618,
24,
36
]
],
[
[
618,
23,
1247
],
[
1247,
23,
36
]
],
[
[
618,
24,
519
],
[
519,
24,
36
]
],
[
[
618,
24,
180
],
[
180,
63,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Eribulin
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Pa... |
DB01124 | DB01193 | 1,411 | 819 | [
"DDInter1828",
"DDInter12"
] | Tolbutamide | Acebutolol | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
1411,
24,
819
]
],
[
[
1411,
63,
887
],
[
887,
1,
819
]
],
[
[
1411,
21,
28762
],
[
28762,
60,
819
]
],
[
[
1411,
63,
417
],
[
417,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Tolbutamide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Acebutolol (Compound)
Tolbutamide may cause a moderate interaction tha... |
DB01278 | DB09100 | 1,021 | 320 | [
"DDInter1506",
"DDInter1799"
] | Pramlintide | Thyroid, porcine | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
1021,
24,
320
]
],
[
[
1021,
63,
417
],
[
417,
23,
320
]
],
[
[
1021,
63,
127
],
[
127,
24,
320
]
],
[
[
1021,
24,
1296
],
[
1296,
... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
],
... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Mi... |
DB00333 | DB11834 | 576 | 1,303 | [
"DDInter1166",
"DDInter849"
] | Methadone | Guselkumab | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
576,
24,
1303
]
],
[
[
576,
63,
58
],
[
58,
24,
1303
]
],
[
[
576,
1,
494
],
[
494,
24,
1303
]
],
[
[
576,
24,
259
],
[
259,
24,... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Methadone (Compound) resembles Disopyramide (Compound) and Disopyramide may cause a moderate interaction that could... |
DB01309 | DB09418 | 1,254 | 554 | [
"DDInter933",
"DDInter1501"
] | Insulin glulisine | Potassium perchlorate | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers has b... | Minor | 0 | [
[
[
1254,
23,
554
]
],
[
[
1254,
63,
914
],
[
914,
24,
554
]
],
[
[
1254,
23,
948
],
[
948,
62,
176
],
[
176,
23,
554
]
],
[
[
1254,
... | [
[
[
"Insulin glulisine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Potassium perchlorate"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difl... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate
Insulin glulisine may cause a minor interaction that can limit clinical effects when taken wit... |
DB01591 | DB06663 | 667 | 1,154 | [
"DDInter1696",
"DDInter1398"
] | Solifenacin | Pasireotide | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
667,
25,
1154
]
],
[
[
667,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
667,
62,
112
],
[
112,
23,
1154
]
],
[
[
667,
24,
1662
],
[
1662,
... | [
[
[
"Solifenacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Solifenacin",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused... | Solifenacin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Solifenacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when tak... |
DB00477 | DB11186 | 216 | 1,609 | [
"DDInter363",
"DDInter1427"
] | Chlorpromazine | Pentoxyverine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
216,
24,
1609
]
],
[
[
216,
1,
508
],
[
508,
24,
1609
]
],
[
[
216,
35,
104
],
[
104,
24,
1609
]
],
[
[
216,
63,
999
],
[
999,
2... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) resembles {v} (Compound)",
"Promazine"
],
[
"Promazine",
"{u} may cause ... | Chlorpromazine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Chlorpromazine (Compound) resembles Methdilazine (Compound) and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01039 | DB01131 | 535 | 1,243 | [
"DDInter718",
"DDInter1531"
] | Fenofibrate | Proguanil | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite. | Moderate | 1 | [
[
[
535,
24,
1243
]
],
[
[
535,
6,
8374
],
[
8374,
45,
1243
]
],
[
[
535,
21,
28658
],
[
28658,
60,
1243
]
],
[
[
535,
64,
126
],
[
126,
... | [
[
[
"Fenofibrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Proguanil"
]
],
[
[
"Fenofibrate",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Fenofibrate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Proguanil (Compound)
Fenofibrate (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Proguanil (Compound)
Fenofibrate may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a m... |
DB00757 | DB01403 | 1,166 | 9 | [
"DDInter581",
"DDInter1175"
] | Dolasetron | Methotrimeprazine | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Major | 2 | [
[
[
1166,
25,
9
]
],
[
[
1166,
25,
1178
],
[
1178,
40,
9
]
],
[
[
1166,
64,
1164
],
[
1164,
1,
9
]
],
[
[
1166,
64,
684
],
[
684,
40... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluoperazine"
],
[
"Trifluoperazi... | Dolasetron may lead to a major life threatening interaction when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Methotrimeprazine (Compound)
Do... |
DB00445 | DB09083 | 322 | 880 | [
"DDInter655",
"DDInter996"
] | Epirubicin | Ivabradine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
322,
25,
880
]
],
[
[
322,
24,
480
],
[
480,
24,
880
]
],
[
[
322,
24,
159
],
[
159,
63,
880
]
],
[
[
322,
25,
752
],
[
752,
24,... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoterol... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Lar... |
DB01155 | DB06810 | 872 | 397 | [
"DDInter813",
"DDInter1484"
] | Gemifloxacin | Plicamycin | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Minor | 0 | [
[
[
872,
23,
397
]
],
[
[
872,
40,
246
],
[
246,
23,
397
]
],
[
[
872,
62,
869
],
[
869,
24,
397
]
],
[
[
872,
63,
1274
],
[
1274,
2... | [
[
[
"Gemifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Plicamycin"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Gatifloxacin"
],
[
"Gatifloxacin",
"{u} may cause a m... | Gemifloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Plicamycin
Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Topotecan and Topotecan may cause a moderate interaction that cou... |
DB01267 | DB01268 | 519 | 1,151 | [
"DDInter1381",
"DDInter1731"
] | Paliperidone | Sunitinib | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
519,
24,
1151
]
],
[
[
519,
64,
1311
],
[
1311,
1,
1151
]
],
[
[
519,
6,
8374
],
[
8374,
45,
1151
]
],
[
[
519,
21,
28653
],
[
28653,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Paliperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
],
[
"Met... | Paliperidone may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Paliperidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sunitinib (Compound)
Paliperidone (Compound) causes Bradycardia (Side Effect) and Bradycardi... |
DB00603 | DB01138 | 303 | 804 | [
"DDInter1137",
"DDInter1726"
] | Medroxyprogesterone acetate | Sulfinpyrazone | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
303,
24,
804
]
],
[
[
303,
24,
998
],
[
998,
1,
804
]
],
[
[
303,
6,
3486
],
[
3486,
45,
804
]
],
[
[
303,
18,
4930
],
[
4930,
5... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Medroxyprogesterone acetate (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfinpyrazone (Compound)
Medroxyprogester... |
DB01403 | DB06595 | 9 | 1,491 | [
"DDInter1175",
"DDInter1214"
] | Methotrimeprazine | Midostaurin | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
9,
24,
1491
]
],
[
[
9,
62,
112
],
[
112,
23,
1491
]
],
[
[
9,
24,
761
],
[
761,
24,
1491
]
],
[
[
9,
63,
888
],
[
888,
24,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"... | Methotrimeprazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Saxa... |
DB06595 | DB15328 | 1,491 | 829 | [
"DDInter1214",
"DDInter1896"
] | Midostaurin | Ubrogepant | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
1491,
24,
829
]
],
[
[
1491,
24,
578
],
[
578,
24,
829
]
],
[
[
1491,
25,
868
],
[
868,
24,
829
]
],
[
[
1491,
63,
86
],
[
86,
2... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Midostaurin may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may ca... |
DB00400 | DB00496 | 353 | 194 | [
"DDInter843",
"DDInter480"
] | Griseofulvin | Darifenacin | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Moderate | 1 | [
[
[
353,
24,
194
]
],
[
[
353,
24,
704
],
[
704,
1,
194
]
],
[
[
353,
63,
576
],
[
576,
1,
194
]
],
[
[
353,
6,
8374
],
[
8374,
45,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darifenacin"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Darifenacin (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Darifenacin (Compound)
... |
DB00191 | DB09080 | 73 | 144 | [
"DDInter1447",
"DDInter1331"
] | Phentermine | Olodaterol | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
73,
24,
144
]
],
[
[
73,
25,
534
],
[
534,
24,
144
]
],
[
[
73,
24,
1445
],
[
1445,
24,
144
]
],
[
[
73,
1,
80
],
[
80,
24,
... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tramadol"
],
[
"Tramadol",... | Phentermine may lead to a major life threatening interaction when taken with Tramadol and Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine ma... |
DB00515 | DB01206 | 589 | 37 | [
"DDInter387",
"DDInter1086"
] | Cisplatin | Lomustine | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
589,
24,
37
]
],
[
[
589,
5,
11555
],
[
11555,
44,
37
]
],
[
[
589,
21,
28675
],
[
28675,
60,
37
]
],
[
[
589,
62,
1176
],
[
1176,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Cisplatin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) ... | Cisplatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Cisplatin (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Lomustine (Compound)
Cisplatin may cause a minor interaction that can limit clinical e... |
DB01175 | DB11978 | 318 | 124 | [
"DDInter672",
"DDInter822"
] | Escitalopram | Glasdegib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
318,
25,
124
]
],
[
[
318,
62,
112
],
[
112,
23,
124
]
],
[
[
318,
63,
475
],
[
475,
24,
124
]
],
[
[
318,
64,
79
],
[
79,
24,
... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Escitalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Escitalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Mor... |
DB00321 | DB00388 | 21 | 1,636 | [
"DDInter78",
"DDInter1453"
] | Amitriptyline | Phenylephrine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Major | 2 | [
[
[
21,
25,
1636
]
],
[
[
21,
25,
874
],
[
874,
40,
1636
]
],
[
[
21,
24,
1148
],
[
1148,
63,
1636
]
],
[
[
21,
6,
3895
],
[
3895,
4... | [
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylephrine"
]
],
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
],
[
"Epinephrine",
... | Amitriptyline may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine (Compound) resembles Phenylephrine (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could... |
DB00214 | DB00992 | 1,028 | 842 | [
"DDInter1836",
"DDInter1182"
] | Torasemide | Methyl aminolevulinate (topical) | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Moderate | 1 | [
[
[
1028,
24,
842
]
],
[
[
1028,
21,
28787
],
[
28787,
60,
842
]
],
[
[
1028,
24,
1274
],
[
1274,
24,
842
]
],
[
[
1028,
24,
820
],
[
820,... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl aminolevulinate"
]
],
[
[
"Torasemide",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side E... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Torasemide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Methyl aminolevulinate (Compound)
Torasemide may cause a moderate interaction that could exacerbate diseases w... |
DB00222 | DB01181 | 245 | 1,532 | [
"DDInter825",
"DDInter906"
] | Glimepiride | Ifosfamide | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
245,
24,
1532
]
],
[
[
245,
6,
6017
],
[
6017,
45,
1532
]
],
[
[
245,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
245,
25,
1299
],
[
1299,... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Glimepiride",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ifosfamide (Compound)
Glimepiride (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Glimepiride may lead to a major life threatening interaction when taken with Trovafloxacin and Trovafl... |
DB00637 | DB06603 | 1,557 | 39 | [
"DDInter128",
"DDInter1387"
] | Astemizole | Panobinostat | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1557,
25,
39
]
],
[
[
1557,
23,
1247
],
[
1247,
23,
39
]
],
[
[
1557,
24,
479
],
[
479,
23,
39
]
],
[
[
1557,
63,
867
],
[
867,
... | [
[
[
"Astemizole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Donepezil a... |
DB00656 | DB00682 | 827 | 126 | [
"DDInter1851",
"DDInter1951"
] | Trazodone | Warfarin | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Minor | 0 | [
[
[
827,
23,
126
]
],
[
[
827,
24,
1376
],
[
1376,
40,
126
]
],
[
[
827,
6,
6943
],
[
6943,
45,
126
]
],
[
[
827,
25,
1053
],
[
1053,
... | [
[
[
"Trazodone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Trazodone (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Warfarin (Compound)
Trazodone may lead to a major life threatening interaction when ta... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.