drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00226 | DB01088 | 1,000 | 714 | [
"DDInter845",
"DDInter908"
] | Guanadrel | Iloprost | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1000,
24,
714
]
],
[
[
1000,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1000,
24,
1445
],
[
1445,
24,
714
]
],
[
[
1000,
24,
22
],
[
22,
... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pse... |
DB01069 | DB08871 | 401 | 36 | [
"DDInter1533",
"DDInter666"
] | Promethazine | Eribulin | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
401,
24,
36
]
],
[
[
401,
63,
122
],
[
122,
23,
36
]
],
[
[
401,
62,
1247
],
[
1247,
23,
36
]
],
[
[
401,
24,
519
],
[
519,
24,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verapamil"
],
[
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Promethazine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulf... |
DB01177 | DB14711 | 77 | 779 | [
"DDInter904",
"DDInter1680"
] | Idarubicin | Smallpox (Vaccinia) Vaccine, Live | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
77,
25,
779
]
],
[
[
77,
64,
1064
],
[
1064,
25,
779
]
],
[
[
77,
25,
478
],
[
478,
25,
779
]
],
[
[
77,
63,
147
],
[
147,
25,
... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cl... | Idarubicin may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Idarubicin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may lead to a major... |
DB00258 | DB00685 | 666 | 1,299 | [
"DDInter270",
"DDInter1887"
] | Calcium acetate | Trovafloxacin | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Moderate | 1 | [
[
[
666,
24,
1299
]
],
[
[
666,
24,
872
],
[
872,
40,
1299
]
],
[
[
666,
21,
28845
],
[
28845,
60,
1299
]
],
[
[
666,
24,
872
],
[
872,
... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Calcium acetate (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Trovafloxacin (Compound)
Calcium acetate may cause a mo... |
DB00950 | DB06212 | 1,413 | 165 | [
"DDInter732",
"DDInter1833"
] | Fexofenadine | Tolvaptan | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
1413,
24,
165
]
],
[
[
1413,
6,
4973
],
[
4973,
45,
165
]
],
[
[
1413,
21,
28681
],
[
28681,
60,
165
]
],
[
[
1413,
24,
466
],
[
466,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Fexofenadine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Fexofenadine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Tolvaptan (Compound)
Fexofenadine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Tolvaptan (Compound)
Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Dar... |
DB00470 | DB11186 | 530 | 1,609 | [
"DDInter601",
"DDInter1427"
] | Dronabinol | Pentoxyverine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
530,
24,
1609
]
],
[
[
530,
24,
314
],
[
314,
24,
1609
]
],
[
[
530,
63,
556
],
[
556,
24,
1609
]
],
[
[
530,
24,
418
],
[
418,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
],
[... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and ... |
DB00582 | DB01166 | 1,622 | 477 | [
"DDInter1946",
"DDInter379"
] | Voriconazole | Cilostazol | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
1622,
25,
477
]
],
[
[
1622,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1622,
21,
28919
],
[
28919,
60,
477
]
],
[
[
1622,
23,
112
],
[
112,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cil... | Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Voriconazole (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole a... |
DB01192 | DB09272 | 560 | 412 | [
"DDInter1372",
"DDInter632"
] | Oxymorphone | Eluxadoline | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
560,
24,
412
]
],
[
[
560,
63,
1594
],
[
1594,
24,
412
]
],
[
[
560,
24,
830
],
[
830,
24,
412
]
],
[
[
560,
75,
475
],
[
475,
2... | [
[
[
"Oxymorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Oxymorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[... | Oxymorphone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Oxymorphone may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and P... |
DB00475 | DB00514 | 1,119 | 506 | [
"DDInter355",
"DDInter527"
] | Chlordiazepoxide | Dextromethorphan | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Moderate | 1 | [
[
[
1119,
24,
506
]
],
[
[
1119,
6,
8374
],
[
8374,
45,
506
]
],
[
[
1119,
1,
902
],
[
902,
24,
506
]
],
[
[
1119,
63,
13
],
[
13,
2... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
]
],
[
[
"Chlordiazepoxide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound b... | Chlordiazepoxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextromethorphan (Compound)
Chlordiazepoxide (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan
Chlordiazepoxide may cause a moderate interact... |
DB06674 | DB08895 | 908 | 976 | [
"DDInter837",
"DDInter1825"
] | Golimumab | Tofacitinib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
908,
25,
976
]
],
[
[
908,
23,
1193
],
[
1193,
62,
976
]
],
[
[
908,
62,
1461
],
[
1461,
23,
976
]
],
[
[
908,
24,
200
],
[
200,
... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Golimumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gluc... | Golimumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Golimumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitami... |
DB06595 | DB09034 | 1,491 | 1,313 | [
"DDInter1214",
"DDInter1733"
] | Midostaurin | Suvorexant | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
1491,
24,
1313
]
],
[
[
1491,
23,
1135
],
[
1135,
62,
1313
]
],
[
[
1491,
63,
1213
],
[
1213,
24,
1313
]
],
[
[
1491,
24,
1619
],
[
16... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Midostaurin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Midostaurin may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Suvorexant
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib m... |
DB08868 | DB08880 | 1,011 | 1,510 | [
"DDInter737",
"DDInter1771"
] | Fingolimod | Teriflunomide | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1011,
25,
1510
]
],
[
[
1011,
25,
129
],
[
129,
63,
1510
]
],
[
[
1011,
24,
221
],
[
221,
63,
1510
]
],
[
[
1011,
63,
1136
],
[
1136,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Fingolimod may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (fo... |
DB01175 | DB11730 | 318 | 351 | [
"DDInter672",
"DDInter1588"
] | Escitalopram | Ribociclib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
318,
25,
351
]
],
[
[
318,
62,
112
],
[
112,
23,
351
]
],
[
[
318,
64,
222
],
[
222,
23,
351
]
],
[
[
318,
24,
283
],
[
283,
62,... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Escitalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Escitalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Escitalopram may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine ma... |
DB00495 | DB11817 | 139 | 1,259 | [
"DDInter1961",
"DDInter165"
] | Zidovudine | Baricitinib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
139,
25,
1259
]
],
[
[
139,
24,
1274
],
[
1274,
24,
1259
]
],
[
[
139,
24,
384
],
[
384,
25,
1259
]
],
[
[
139,
24,
1619
],
[
1619,
... | [
[
[
"Zidovudine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
"Flurbip... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and I... |
DB00029 | DB15035 | 25 | 503 | [
"DDInter99",
"DDInter1959"
] | Anistreplase | Zanubrutinib | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
25,
25,
503
]
],
[
[
25,
24,
222
],
[
222,
24,
503
]
],
[
[
25,
25,
39
],
[
39,
25,
503
]
],
[
[
25,
24,
1018
],
[
1018,
25,
... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sib... | Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Anistreplase may lead to a major life threatening interaction when taken with Panobinostat and Panobinosta... |
DB00603 | DB15822 | 303 | 69 | [
"DDInter1137",
"DDInter1504"
] | Medroxyprogesterone acetate | Pralsetinib | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
303,
24,
69
]
],
[
[
303,
24,
283
],
[
283,
24,
69
]
],
[
[
303,
63,
1560
],
[
1560,
24,
69
]
],
[
[
303,
25,
1040
],
[
1040,
24... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases wh... |
DB00999 | DB01156 | 504 | 593 | [
"DDInter883",
"DDInter252"
] | Hydrochlorothiazide | Bupropion | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
504,
24,
593
]
],
[
[
504,
18,
4930
],
[
4930,
57,
593
]
],
[
[
504,
21,
29220
],
[
29220,
60,
593
]
],
[
[
504,
62,
126
],
[
126,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Hydrochlorothiazide",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downre... | Hydrochlorothiazide (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Bupropion (Compound)
Hydrochlorothiazide (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Bupropion (Compound)
Hydrochlorothiazide may cause a minor interaction that can lim... |
DB00526 | DB09330 | 1,555 | 985 | [
"DDInter1355",
"DDInter1352"
] | Oxaliplatin | Osimertinib | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1555,
25,
985
]
],
[
[
1555,
63,
168
],
[
168,
23,
985
]
],
[
[
1555,
23,
1247
],
[
1247,
23,
985
]
],
[
[
1555,
24,
112
],
[
112,
... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezo... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Oxaliplatin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and S... |
DB00549 | DB14840 | 522 | 861 | [
"DDInter1955",
"DDInter1601"
] | Zafirlukast | Ripretinib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
522,
24,
861
]
],
[
[
522,
24,
351
],
[
351,
24,
861
]
],
[
[
522,
63,
597
],
[
597,
24,
861
]
],
[
[
522,
24,
384
],
[
384,
25,... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and... |
DB00604 | DB01406 | 1,425 | 984 | [
"DDInter385",
"DDInter472"
] | Cisapride | Danazol | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Major | 2 | [
[
[
1425,
25,
984
]
],
[
[
1425,
6,
8374
],
[
8374,
45,
984
]
],
[
[
1425,
18,
12106
],
[
12106,
57,
984
]
],
[
[
1425,
40,
883
],
[
883,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danazol"
]
],
[
[
"Cisapride",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Danazol"
... | Cisapride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Danazol (Compound)
Cisapride (Compound) downregulates NT5DC2 (Gene) and NT5DC2 (Gene) is downregulated by Danazol (Compound)
Cisapride (Compound) resembles Gefitinib (Compound) and Gefitinib may cause a moderate interaction that could exacerbate dis... |
DB00619 | DB06605 | 1,419 | 1,409 | [
"DDInter909",
"DDInter108"
] | Imatinib | Apixaban | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
1419,
24,
1409
]
],
[
[
1419,
6,
10215
],
[
10215,
45,
1409
]
],
[
[
1419,
21,
29666
],
[
29666,
60,
1409
]
],
[
[
1419,
23,
307
],
[
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Apixaban (Compound)
Imatinib (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Imatinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause... |
DB01236 | DB11113 | 679 | 657 | [
"DDInter1664",
"DDInter307"
] | Sevoflurane | Castor oil | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
679,
24,
657
]
],
[
[
679,
24,
927
],
[
927,
63,
657
]
],
[
[
679,
24,
1491
],
[
1491,
24,
657
]
],
[
[
679,
1,
1262
],
[
1262,
... | [
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[... | Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and M... |
DB01242 | DB06228 | 1,237 | 792 | [
"DDInter410",
"DDInter1609"
] | Clomipramine | Rivaroxaban | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1237,
24,
792
]
],
[
[
1237,
6,
4973
],
[
4973,
45,
792
]
],
[
[
1237,
21,
28703
],
[
28703,
60,
792
]
],
[
[
1237,
63,
752
],
[
752,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Clomipramine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound... | Clomipramine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Clomipramine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and ... |
DB00209 | DB01224 | 352 | 623 | [
"DDInter1886",
"DDInter1553"
] | Trospium | Quetiapine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
352,
24,
623
]
],
[
[
352,
24,
695
],
[
695,
1,
623
]
],
[
[
352,
6,
7992
],
[
7992,
45,
623
]
],
[
[
352,
21,
28970
],
[
28970,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
"... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Trospium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Quetiapine (Compound)
Trospium (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect)... |
DB00418 | DB00692 | 536 | 274 | [
"DDInter1650",
"DDInter1448"
] | Secobarbital | Phentolamine | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
536,
24,
274
]
],
[
[
536,
21,
28766
],
[
28766,
60,
274
]
],
[
[
536,
24,
530
],
[
530,
24,
274
]
],
[
[
536,
24,
104
],
[
104,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Secobarbital",
"{u} (Compound) causes {v} (Side Effect)",
"Hypotension"
],
[
"Hypotension",
"{u} (Side Effec... | Secobarbital (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Phentolamine (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB01095 | DB11158 | 671 | 1,452 | [
"DDInter769",
"DDInter1401"
] | Fluvastatin | Pectin | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts o... | Moderate | 1 | [
[
[
671,
24,
1452
]
],
[
[
671,
1,
700
],
[
700,
24,
1452
]
],
[
[
671,
63,
467
],
[
467,
24,
1452
]
],
[
[
671,
1,
700
],
[
700,
63... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pectin"
]
],
[
[
"Fluvastatin",
"{u} (Compound) resembles {v} (Compound)",
"Atorvastatin"
],
[
"Atorvastatin",
"{u} may cause a moder... | Fluvastatin (Compound) resembles Atorvastatin (Compound) and Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Pectin
Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that c... |
DB01005 | DB01101 | 995 | 60 | [
"DDInter894",
"DDInter285"
] | Hydroxyurea | Capecitabine | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Moderate | 1 | [
[
[
995,
24,
60
]
],
[
[
995,
21,
28701
],
[
28701,
60,
60
]
],
[
[
995,
23,
872
],
[
872,
62,
60
]
],
[
[
995,
62,
1176
],
[
1176,
... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
]
],
[
[
"Hydroxyurea",
"{u} (Compound) causes {v} (Side Effect)",
"Discomfort"
],
[
"Discomfort",
"{u} (Side Effect) i... | Hydroxyurea (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Capecitabine (Compound)
Hydroxyurea may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with C... |
DB00222 | DB01357 | 245 | 890 | [
"DDInter825",
"DDInter1160"
] | Glimepiride | Mestranol | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
245,
24,
890
]
],
[
[
245,
24,
1197
],
[
1197,
40,
890
]
],
[
[
245,
24,
559
],
[
559,
1,
890
]
],
[
[
245,
6,
6017
],
[
6017,
4... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) resembles Mestranol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Estrone and Estrone (Compound) resembles Mestranol (Compound... |
DB09073 | DB09498 | 951 | 810 | [
"DDInter1379",
"DDInter1715"
] | Palbociclib | Strontium chloride Sr-89 | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
951,
24,
810
]
],
[
[
951,
63,
597
],
[
597,
24,
810
]
],
[
[
951,
24,
503
],
[
503,
63,
810
]
],
[
[
951,
64,
976
],
[
976,
24,... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphen... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00945 | DB11642 | 1,479 | 938 | [
"DDInter20",
"DDInter1480"
] | Acetylsalicylic acid | Pitolisant | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1479,
24,
938
]
],
[
[
1479,
63,
473
],
[
473,
24,
938
]
],
[
[
1479,
24,
617
],
[
617,
24,
938
]
],
[
[
1479,
25,
1421
],
[
1421,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repagli... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with... |
DB06448 | DB11828 | 171 | 1,406 | [
"DDInter1087",
"DDInter1281"
] | Lonafarnib | Neratinib | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
171,
25,
1406
]
],
[
[
171,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
171,
64,
392
],
[
392,
24,
1406
]
],
[
[
171,
63,
1195
],
[
1195,
... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Lonafarnib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Lonafarnib may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate interaction... |
DB00861 | DB09293 | 914 | 116 | [
"DDInter551",
"DDInter954"
] | Diflunisal | Iodide I-131 | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
914,
24,
116
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],
[
[
914,
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],
[
1486,
24,
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],
[
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167
],
[
167,
24,
116
]
],
[
[
914,
25,
365
],
[
365,
2... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Hyd... |
DB00738 | DB00916 | 485 | 112 | [
"DDInter1420",
"DDInter1202"
] | Pentamidine | Metronidazole | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
485,
23,
112
]
],
[
[
485,
6,
3486
],
[
3486,
45,
112
]
],
[
[
485,
21,
28757
],
[
28757,
60,
112
]
],
[
[
485,
63,
847
],
[
847,
... | [
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Pentamidine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Pentamidine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Metronidazole (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetin... |
DB00563 | DB00880 | 663 | 359 | [
"DDInter1174",
"DDInter360"
] | Methotrexate | Chlorothiazide | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Moderate | 1 | [
[
[
663,
24,
359
]
],
[
[
663,
24,
1577
],
[
1577,
1,
359
]
],
[
[
663,
63,
1014
],
[
1014,
1,
359
]
],
[
[
663,
6,
10612
],
[
10612,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) rese... |
DB01165 | DB11057 | 1,539 | 720 | [
"DDInter1325",
"DDInter1223"
] | Ofloxacin | Mineral oil | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1539,
24,
720
]
],
[
[
1539,
24,
927
],
[
927,
63,
720
]
],
[
[
1539,
64,
175
],
[
175,
24,
720
]
],
[
[
1539,
24,
1151
],
[
1151,
... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Ofloxacin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone may... |
DB06218 | DB09054 | 136 | 384 | [
"DDInter1014",
"DDInter905"
] | Lacosamide | Idelalisib | Lacosamide is an antiepileptic drug used to treat seizures. As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated sodium currents. Lacosamide exhibits a stereoselective mode of interaction with sodium channels. Lacosamide was first approved by the European Commissio... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
136,
24,
384
]
],
[
[
136,
63,
1010
],
[
1010,
24,
384
]
],
[
[
136,
1,
168
],
[
168,
24,
384
]
],
[
[
136,
24,
760
],
[
760,
63... | [
[
[
"Lacosamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Lacosamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
],
[
... | Lacosamide may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Lacosamide (Compound) resembles Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could... |
DB00969 | DB12130 | 2 | 1,017 | [
"DDInter52",
"DDInter1094"
] | Alosetron | Lorlatinib | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
2,
24,
1017
]
],
[
[
2,
64,
529
],
[
529,
24,
1017
]
],
[
[
2,
24,
214
],
[
214,
24,
1017
]
],
[
[
2,
63,
1288
],
[
1288,
24,
... | [
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Alosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluvoxamine"
],
[
"Fluvoxamine... | Alosetron may lead to a major life threatening interaction when taken with Fluvoxamine and Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may ca... |
DB00026 | DB14004 | 1,184 | 398 | [
"DDInter94",
"DDInter1806"
] | Anakinra | Tildrakizumab | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis . The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psorias... | Moderate | 1 | [
[
[
1184,
24,
398
]
],
[
[
1184,
23,
1114
],
[
1114,
23,
398
]
],
[
[
1184,
24,
58
],
[
58,
24,
398
]
],
[
[
1184,
24,
1129
],
[
1129,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tildrakizumab"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Tildrakizumab
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacep... |
DB00370 | DB04868 | 1,251 | 478 | [
"DDInter1230",
"DDInter1293"
] | Mirtazapine | Nilotinib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1251,
25,
478
]
],
[
[
1251,
6,
6017
],
[
6017,
45,
478
]
],
[
[
1251,
6,
3576
],
[
3576,
46,
478
]
],
[
[
1251,
18,
10699
],
[
10699,... | [
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Niloti... | Mirtazapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Mirtazapine (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is upregulated by Nilotinib (Compound)
Mirtazapine (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Nilotinib (Compound)
Mirtazapine (Compo... |
DB00959 | DB04865 | 1,486 | 4 | [
"DDInter1191",
"DDInter1335"
] | Methylprednisolone | Omacetaxine mepesuccinate | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1486,
24,
4
]
],
[
[
1486,
7,
3163
],
[
3163,
46,
4
]
],
[
[
1486,
18,
6420
],
[
6420,
46,
4
]
],
[
[
1486,
6,
1899
],
[
1899,
4... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) upregulates {v} (Gene)",
"TSC22D3"
],
[
"TSC22D3",
"... | Methylprednisolone (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Methylprednisolone (Compound) downregulates FOSL1 (Gene) and FOSL1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Methylprednisolone (Compound) binds NR3C1 (Gene) and NR3C1 (... |
DB00371 | DB06691 | 1,050 | 849 | [
"DDInter1154",
"DDInter1155"
] | Meprobamate | Mepyramine | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1050,
24,
849
]
],
[
[
1050,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1050,
24,
272
],
[
272,
24,
849
]
],
[
[
1050,
24,
407
],
[
407,
... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine an... |
DB00357 | DB13074 | 1,051 | 877 | [
"DDInter71",
"DDInter1110"
] | Aminoglutethimide | Macimorelin | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
1051,
24,
877
]
],
[
[
1051,
24,
1320
],
[
1320,
24,
877
]
],
[
[
1051,
62,
1101
],
[
1101,
24,
877
]
],
[
[
1051,
24,
478
],
[
478,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Bexarotene a... |
DB00673 | DB01182 | 723 | 371 | [
"DDInter112",
"DDInter1534"
] | Aprepitant | Propafenone | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
723,
24,
371
]
],
[
[
723,
25,
704
],
[
704,
1,
371
]
],
[
[
723,
23,
271
],
[
271,
1,
371
]
],
[
[
723,
24,
939
],
[
939,
40,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
... | Aprepitant may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Propafenone (Compound)
Aprepitant may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron (Compound) resembles Propafenone (Compound)
Aprepitant may caus... |
DB00277 | DB11834 | 1,031 | 1,303 | [
"DDInter1791",
"DDInter849"
] | Theophylline | Guselkumab | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
1031,
24,
1303
]
],
[
[
1031,
23,
902
],
[
902,
24,
1303
]
],
[
[
1031,
63,
58
],
[
58,
24,
1303
]
],
[
[
1031,
24,
494
],
[
494,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clobazam"
],
[
... | Theophylline may cause a minor interaction that can limit clinical effects when taken with Clobazam and Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept... |
DB00401 | DB00635 | 84 | 1,573 | [
"DDInter1298",
"DDInter1515"
] | Nisoldipine | Prednisone | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
84,
24,
1573
]
],
[
[
84,
24,
175
],
[
175,
40,
1573
]
],
[
[
84,
24,
251
],
[
251,
1,
1573
]
],
[
[
84,
6,
8374
],
[
8374,
45,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Predniso... |
DB01218 | DB12267 | 1,493 | 1,476 | [
"DDInter852",
"DDInter233"
] | Halofantrine | Brigatinib | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1493,
24,
1476
]
],
[
[
1493,
25,
1612
],
[
1612,
23,
1476
]
],
[
[
1493,
63,
629
],
[
629,
24,
1476
]
],
[
[
1493,
25,
800
],
[
800,
... | [
[
[
"Halofantrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
],
[
"Foste... | Halofantrine may lead to a major life threatening interaction when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may caus... |
DB00980 | DB01234 | 969 | 1,220 | [
"DDInter1564",
"DDInter513"
] | Ramelteon | Dexamethasone | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
969,
24,
1220
]
],
[
[
969,
6,
10215
],
[
10215,
45,
1220
]
],
[
[
969,
21,
29106
],
[
29106,
60,
1220
]
],
[
[
969,
63,
1018
],
[
101... | [
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Ramelteon",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound... | Ramelteon (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexamethasone (Compound)
Ramelteon (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Dexamethasone (Compound)
Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ti... |
DB08820 | DB09065 | 1,478 | 760 | [
"DDInter997",
"DDInter424"
] | Ivacaftor | Cobicistat | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
1478,
25,
760
]
],
[
[
1478,
62,
479
],
[
479,
23,
760
]
],
[
[
1478,
24,
1627
],
[
1627,
23,
760
]
],
[
[
1478,
23,
271
],
[
271,
... | [
[
[
"Ivacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Ivacaftor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
"Donepezil",
... | Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol m... |
DB00357 | DB06016 | 1,051 | 1,508 | [
"DDInter71",
"DDInter300"
] | Aminoglutethimide | Cariprazine | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1051,
24,
1508
]
],
[
[
1051,
24,
1593
],
[
1593,
63,
1508
]
],
[
[
1051,
24,
1213
],
[
1213,
24,
1508
]
],
[
[
1051,
62,
245
],
[
245... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Dasati... |
DB01076 | DB08865 | 700 | 1,593 | [
"DDInter133",
"DDInter448"
] | Atorvastatin | Crizotinib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
700,
24,
1593
]
],
[
[
700,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
700,
7,
5077
],
[
5077,
46,
1593
]
],
[
[
700,
6,
8559
],
[
8559,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Atorvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Atorvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Atorvastatin (Compound) upregulates MVP (Gene) and MVP (Gene) is upregulated by Crizotinib (Compound)
Atorvastatin (Compound) binds HMGCR (Gene) and HMGCR (Gene) is upregulated by Crizotinib (Compound)
Atorvastatin (Compound... |
DB00011 | DB04865 | 1,451 | 4 | [
"DDInter944",
"DDInter1335"
] | Interferon alfa-n1 | Omacetaxine mepesuccinate | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1451,
24,
4
]
],
[
[
1451,
24,
770
],
[
770,
24,
4
]
],
[
[
1451,
24,
713
],
[
713,
63,
4
]
],
[
[
1451,
25,
1101
],
[
1101,
24,... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when... |
DB09330 | DB11901 | 985 | 913 | [
"DDInter1352",
"DDInter107"
] | Osimertinib | Apalutamide | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
985,
25,
913
]
],
[
[
985,
62,
112
],
[
112,
23,
913
]
],
[
[
985,
63,
1322
],
[
1322,
24,
913
]
],
[
[
985,
64,
600
],
[
600,
2... | [
[
[
"Osimertinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Osimertinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Osimertinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Alfentanil and A... |
DB00215 | DB04868 | 1,230 | 478 | [
"DDInter388",
"DDInter1293"
] | Citalopram | Nilotinib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1230,
25,
478
]
],
[
[
1230,
24,
1468
],
[
1468,
63,
478
]
],
[
[
1230,
6,
4973
],
[
4973,
45,
478
]
],
[
[
1230,
7,
8587
],
[
8587,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Citalopram (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Citalopram (Compound) up... |
DB00938 | DB01268 | 455 | 1,151 | [
"DDInter1635",
"DDInter1731"
] | Salmeterol | Sunitinib | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
455,
24,
1151
]
],
[
[
455,
18,
2284
],
[
2284,
45,
1151
]
],
[
[
455,
6,
6799
],
[
6799,
45,
1151
]
],
[
[
455,
7,
9650
],
[
9650,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Salmeterol",
"{u} (Compound) downregulates {v} (Gene)",
"PRPF4"
],
[
"PRPF4",
"{u} (Gene) is bound by {v} (Compou... | Salmeterol (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is bound by Sunitinib (Compound)
Salmeterol (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Sunitinib (Compound)
Salmeterol (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Sunitinib (Compound)
Salmeterol (Compound) d... |
DB00055 | DB11312 | 834 | 298 | [
"DDInter605",
"DDInter1542"
] | Drotrecogin alfa | Protein C | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the e... | Moderate | 1 | [
[
[
834,
24,
298
]
],
[
[
834,
25,
707
],
[
707,
24,
298
]
],
[
[
834,
24,
321
],
[
321,
63,
298
]
],
[
[
834,
64,
582
],
[
582,
24,... | [
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Protein C
Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib and Selumetin... |
DB00342 | DB00776 | 1,181 | 1,335 | [
"DDInter1770",
"DDInter1360"
] | Terfenadine | Oxcarbazepine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
1181,
24,
1335
]
],
[
[
1181,
24,
1264
],
[
1264,
63,
1335
]
],
[
[
1181,
24,
1236
],
[
1236,
1,
1335
]
],
[
[
1181,
63,
21
],
[
21,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carb... |
DB01072 | DB09075 | 915 | 498 | [
"DDInter129",
"DDInter621"
] | Atazanavir | Edoxaban | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
915,
25,
498
]
],
[
[
915,
25,
1017
],
[
1017,
63,
498
]
],
[
[
915,
24,
1496
],
[
1496,
63,
498
]
],
[
[
915,
24,
129
],
[
129,
... | [
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
],
[
"Lorlatinib",
"{u} may... | Atazanavir may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cause a ... |
DB01133 | DB01377 | 1,104 | 1,283 | [
"DDInter1808",
"DDInter1119"
] | Tiludronic acid | Magnesium oxide | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
1104,
24,
1283
]
],
[
[
1104,
63,
1479
],
[
1479,
24,
1283
]
],
[
[
1104,
24,
286
],
[
286,
63,
1283
]
],
[
[
1104,
63,
1479
],
[
1479... | [
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicy... | Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide
Tiludronic acid may cause a moderate interaction that could exacerbate diseases wh... |
DB00284 | DB00294 | 1,647 | 1,336 | [
"DDInter11",
"DDInter701"
] | Acarbose | Etonogestrel | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Moderate | 1 | [
[
[
1647,
24,
1336
]
],
[
[
1647,
24,
566
],
[
566,
1,
1336
]
],
[
[
1647,
21,
28900
],
[
28900,
60,
1336
]
],
[
[
1647,
24,
629
],
[
629,... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etonogestrel"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Etonogestrel (Compound)
Acarbose (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Etonogestrel (Compound)
Acarbose may cause a moder... |
DB01208 | DB06603 | 945 | 39 | [
"DDInter1705",
"DDInter1387"
] | Sparfloxacin | Panobinostat | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
945,
25,
39
]
],
[
[
945,
62,
112
],
[
112,
23,
39
]
],
[
[
945,
63,
455
],
[
455,
24,
39
]
],
[
[
945,
62,
869
],
[
869,
24,
... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Sparfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol an... |
DB01232 | DB12364 | 1,327 | 1,421 | [
"DDInter1640",
"DDInter200"
] | Saquinavir | Betrixaban | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1327,
25,
1421
]
],
[
[
1327,
25,
1017
],
[
1017,
24,
1421
]
],
[
[
1327,
24,
760
],
[
760,
24,
1421
]
],
[
[
1327,
1,
915
],
[
915,
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
],
[
"Lorlatinib",
"{u} m... | Saquinavir may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause ... |
DB00612 | DB00804 | 1,121 | 1,507 | [
"DDInter216",
"DDInter543"
] | Bisoprolol | Dicyclomine | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
1121,
24,
1507
]
],
[
[
1121,
21,
29231
],
[
29231,
60,
1507
]
],
[
[
1121,
63,
475
],
[
475,
24,
1507
]
],
[
[
1121,
24,
1511
],
[
15... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Bisoprolol",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
"{u} (Side ... | Bisoprolol (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Dicyclomine (Compound)
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00400 | DB12001 | 353 | 564 | [
"DDInter843",
"DDInter7"
] | Griseofulvin | Abemaciclib | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
353,
24,
564
]
],
[
[
353,
24,
536
],
[
536,
24,
564
]
],
[
[
353,
63,
288
],
[
288,
24,
564
]
],
[
[
353,
62,
1101
],
[
1101,
2... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Butalbital a... |
DB00477 | DB06603 | 216 | 39 | [
"DDInter363",
"DDInter1387"
] | Chlorpromazine | Panobinostat | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
216,
25,
39
]
],
[
[
216,
23,
112
],
[
112,
23,
39
]
],
[
[
216,
35,
272
],
[
272,
24,
39
]
],
[
[
216,
24,
506
],
[
506,
24,
... | [
[
[
"Chlorpromazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Chlorpromazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Chlorpromazine (Compound) resembles Chlorpheniramine (Compound) and Chlorpromazine may cause a moderate ... |
DB00434 | DB08897 | 13 | 1,429 | [
"DDInter459",
"DDInter22"
] | Cyproheptadine | Aclidinium | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
13,
24,
1429
]
],
[
[
13,
63,
352
],
[
352,
24,
1429
]
],
[
[
13,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
13,
6,
4304
],
[
4304,
4... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and M... |
DB00218 | DB00444 | 1,176 | 63 | [
"DDInter1247",
"DDInter1765"
] | Moxifloxacin | Teniposide | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Minor | 0 | [
[
[
1176,
23,
63
]
],
[
[
1176,
21,
28709
],
[
28709,
60,
63
]
],
[
[
1176,
1,
1467
],
[
1467,
62,
63
]
],
[
[
1176,
23,
147
],
[
147,
... | [
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Teniposide"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Decreased appetite"
],
[
"Decreased appetite",
"{u} (... | Moxifloxacin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Teniposide (Compound)
Moxifloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin may cause a minor interaction that can limit clinical effects when taken with Teniposide
Moxifloxacin may cause a min... |
DB00694 | DB08868 | 51 | 1,011 | [
"DDInter485",
"DDInter737"
] | Daunorubicin | Fingolimod | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
51,
25,
1011
]
],
[
[
51,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
51,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
51,
23,
1247
],
[
1247,
... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Daunorubicin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fin... | Daunorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Daunorubicin (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Sulfa... |
DB00394 | DB01344 | 218 | 1,231 | [
"DDInter168",
"DDInter1830"
] | Beclomethasone dipropionate | Tolevamer | Beclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to [dexamethasone]. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor to mediates its therapeutic action. Bec... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
218,
24,
1231
]
],
[
[
218,
1,
175
],
[
175,
24,
1231
]
],
[
[
218,
1,
175
],
[
175,
23,
1114
],
[
1114,
63,
1231
]
],
[
[
218,
... | [
[
[
"Beclomethasone dipropionate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Beclomethasone dipropionate",
"{u} (Compound) resembles {v} (Compound)",
"Triamcinolone"
],
[
"Triamci... | Beclomethasone dipropionate (Compound) resembles Triamcinolone (Compound) and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Beclomethasone dipropionate (Compound) resembles Triamcinolone (Compound) and Triamcinolone may cause a minor interaction that can limit c... |
DB00455 | DB00834 | 1,601 | 932 | [
"DDInter1091",
"DDInter1215"
] | Loratadine | Mifepristone | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Moderate | 1 | [
[
[
1601,
24,
932
]
],
[
[
1601,
6,
4973
],
[
4973,
45,
932
]
],
[
[
1601,
7,
7669
],
[
7669,
46,
932
]
],
[
[
1601,
18,
16974
],
[
16974,... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mifepristone"
]
],
[
[
"Loratadine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Loratadine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mifepristone (Compound)
Loratadine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Mifepristone (Compound)
Loratadine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Mifepristone (Compound)
Loratadine... |
DB00673 | DB01229 | 723 | 973 | [
"DDInter112",
"DDInter1377"
] | Aprepitant | Paclitaxel | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
723,
24,
973
]
],
[
[
723,
24,
310
],
[
310,
63,
973
]
],
[
[
723,
10,
11579
],
[
11579,
44,
973
]
],
[
[
723,
6,
7524
],
[
7524,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Aprepitant (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is treated by Paclitaxel (... |
DB00590 | DB01088 | 1,433 | 714 | [
"DDInter592",
"DDInter908"
] | Doxazosin | Iloprost | Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin]. Because of its long-lasting effects, doxazosin can be administered once a day. It is marketed by Pfi... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1433,
24,
714
]
],
[
[
1433,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1433,
1,
1205
],
[
1205,
24,
714
]
],
[
[
1433,
24,
1445
],
[
1445,
... | [
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Doxazosin (Compound) resembles Prazosin (Compound) and Prazosin may cause a moderate interaction that could exace... |
DB01128 | DB09054 | 918 | 384 | [
"DDInter204",
"DDInter905"
] | Bicalutamide | Idelalisib | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
918,
24,
384
]
],
[
[
918,
25,
318
],
[
318,
23,
384
]
],
[
[
918,
64,
1230
],
[
1230,
23,
384
]
],
[
[
918,
24,
1627
],
[
1627,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Esci... | Bicalutamide may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Bicalutamide may lead to a major life threatening interaction when taken with Citalopram and Citalopram may cause a minor i... |
DB00938 | DB05812 | 455 | 1,374 | [
"DDInter1635",
"DDInter8"
] | Salmeterol | Abiraterone | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
455,
24,
1374
]
],
[
[
455,
6,
8374
],
[
8374,
45,
1374
]
],
[
[
455,
21,
28809
],
[
28809,
60,
1374
]
],
[
[
455,
25,
74
],
[
74,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Salmeterol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Salmeterol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Abiraterone (Compound)
Salmeterol (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Salmeterol may lead to a major life threatening interaction when taken with Boceprevir and Boceprevir may ca... |
DB00682 | DB06603 | 126 | 39 | [
"DDInter1951",
"DDInter1387"
] | Warfarin | Panobinostat | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
126,
25,
39
]
],
[
[
126,
25,
1247
],
[
1247,
23,
39
]
],
[
[
126,
24,
211
],
[
211,
23,
39
]
],
[
[
126,
63,
912
],
[
912,
24,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfamethoxazole",
... | Warfarin may lead to a major life threatening interaction when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine ... |
DB00694 | DB01004 | 51 | 563 | [
"DDInter485",
"DDInter806"
] | Daunorubicin | Ganciclovir | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Moderate | 1 | [
[
[
51,
24,
563
]
],
[
[
51,
24,
248
],
[
248,
40,
563
]
],
[
[
51,
7,
2216
],
[
2216,
46,
563
]
],
[
[
51,
18,
17695
],
[
17695,
57... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Daunorubicin (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Ganciclovir (Compound)
Daunorubicin (Compound) downregulates CANT1 ... |
DB00834 | DB08865 | 932 | 1,593 | [
"DDInter1215",
"DDInter448"
] | Mifepristone | Crizotinib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
932,
25,
1593
]
],
[
[
932,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
932,
7,
18110
],
[
18110,
46,
1593
]
],
[
[
932,
6,
1899
],
[
1899,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Mifepristone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cri... | Mifepristone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Mifepristone (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Crizotinib (Compound)
Mifepristone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is upregulated by Crizotinib (Compound)
Mifepris... |
DB00011 | DB08860 | 1,451 | 788 | [
"DDInter944",
"DDInter1479"
] | Interferon alfa-n1 | Pitavastatin | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
1451,
24,
788
]
],
[
[
1451,
24,
671
],
[
671,
1,
788
]
],
[
[
1451,
24,
700
],
[
700,
40,
788
]
],
[
[
1451,
24,
126
],
[
126,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastat... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resemble... |
DB00986 | DB04946 | 1,192 | 924 | [
"DDInter834",
"DDInter907"
] | Glycopyrronium | Iloperidone | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
1192,
24,
924
]
],
[
[
1192,
63,
1664
],
[
1664,
1,
924
]
],
[
[
1192,
63,
1425
],
[
1425,
25,
924
]
],
[
[
1192,
24,
519
],
[
519,
... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Cisapride and Cisapride may lead to a major life threateni... |
DB00604 | DB05294 | 1,425 | 1,069 | [
"DDInter385",
"DDInter1917"
] | Cisapride | Vandetanib | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1425,
25,
1069
]
],
[
[
1425,
40,
883
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[
883,
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[
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[
8374,
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],
[
[
1425,
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1194
],
[
1194,... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Cisapride",
"{u} (Compound) resembles {v} (Compound)",
"Gefitinib"
],
[
"Gefitinib",
"{u} (Compound) resembles {v} (Compound)",
... | Cisapride (Compound) resembles Gefitinib (Compound) and Gefitinib (Compound) resembles Vandetanib (Compound)
Cisapride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Cisapride may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine may ... |
DB00543 | DB09076 | 87 | 1,116 | [
"DDInter82",
"DDInter1899"
] | Amoxapine | Umeclidinium | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
87,
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],
[
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87,
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],
[
849,
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[
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87,
1,
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[
695,
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1116
]
],
[
[
87,
40,
1408
],
[
1408,
24,... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Amoxapine (Compound) resembles Clozapine (Compound) and Clozapine may cause a moderate interaction that could e... |
DB00314 | DB00526 | 894 | 1,555 | [
"DDInter288",
"DDInter1355"
] | Capreomycin | Oxaliplatin | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
894,
24,
1555
]
],
[
[
894,
24,
1441
],
[
1441,
63,
1555
]
],
[
[
894,
25,
1132
],
[
1132,
63,
1555
]
],
[
[
894,
24,
91
],
[
91,
... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacitracin"
],
[... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Capreomycin may lead to a major life threatening interaction when taken with Gentamicin and Gentamicin may cau... |
DB00029 | DB06779 | 25 | 365 | [
"DDInter99",
"DDInter470"
] | Anistreplase | Dalteparin | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
25,
25,
365
]
],
[
[
25,
23,
539
],
[
539,
62,
365
]
],
[
[
25,
24,
954
],
[
954,
24,
365
]
],
[
[
25,
24,
1496
],
[
1496,
63,
... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Anistreplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",... | Anistreplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril m... |
DB06372 | DB14004 | 259 | 398 | [
"DDInter1594",
"DDInter1806"
] | Rilonacept | Tildrakizumab | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis . The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psorias... | Moderate | 1 | [
[
[
259,
24,
398
]
],
[
[
259,
23,
1114
],
[
1114,
23,
398
]
],
[
[
259,
62,
1461
],
[
1461,
23,
398
]
],
[
[
259,
63,
58
],
[
58,
2... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tildrakizumab"
]
],
[
[
"Rilonacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[... | Rilonacept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Tildrakizumab
Rilonacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitami... |
DB00477 | DB01064 | 216 | 1,148 | [
"DDInter363",
"DDInter987"
] | Chlorpromazine | Isoprenaline | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
216,
24,
1148
]
],
[
[
216,
24,
480
],
[
480,
24,
1148
]
],
[
[
216,
21,
28695
],
[
28695,
60,
1148
]
],
[
[
216,
24,
167
],
[
167,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Chlorpromazine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Isoprenali... |
DB00834 | DB06754 | 932 | 707 | [
"DDInter1215",
"DDInter471"
] | Mifepristone | Danaparoid | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
932,
25,
707
]
],
[
[
932,
24,
1496
],
[
1496,
63,
707
]
],
[
[
932,
25,
1151
],
[
1151,
24,
707
]
],
[
[
932,
25,
235
],
[
235,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
],
[
"Ninted... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Mifepristone may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may caus... |
DB00760 | DB11718 | 1,584 | 927 | [
"DDInter1157",
"DDInter640"
] | Meropenem | Encorafenib | Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. In August 2017, a combination antibacterial ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1584,
24,
927
]
],
[
[
1584,
24,
1662
],
[
1662,
24,
927
]
],
[
[
1584,
24,
1033
],
[
1033,
63,
927
]
],
[
[
1584,
24,
1662
],
[
1662,... | [
[
[
"Meropenem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Meropenem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
],
... | Meropenem may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Meropenem may cause a moderate interaction that could exacerbate diseases when taken with Alpelisi... |
DB00400 | DB00843 | 353 | 479 | [
"DDInter843",
"DDInter583"
] | Griseofulvin | Donepezil | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
353,
24,
479
]
],
[
[
353,
6,
8374
],
[
8374,
45,
479
]
],
[
[
353,
21,
28746
],
[
28746,
60,
479
]
],
[
[
353,
24,
723
],
[
723,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Donepezil (Compound)
Griseofulvin (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Donepezil (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Ap... |
DB00682 | DB09100 | 126 | 320 | [
"DDInter1951",
"DDInter1799"
] | Warfarin | Thyroid, porcine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
126,
24,
320
]
],
[
[
126,
63,
417
],
[
417,
23,
320
]
],
[
[
126,
62,
467
],
[
467,
23,
320
]
],
[
[
126,
23,
135
],
[
135,
24,... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Warfarin may cause a minor interaction that can limit clinical effects when taken with Simvastatin and Simvast... |
DB00773 | DB01095 | 896 | 671 | [
"DDInter702",
"DDInter769"
] | Etoposide | Fluvastatin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Moderate | 1 | [
[
[
896,
24,
671
]
],
[
[
896,
24,
788
],
[
788,
40,
671
]
],
[
[
896,
24,
14
],
[
14,
63,
671
]
],
[
[
896,
6,
7950
],
[
7950,
45,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction tha... |
DB01365 | DB08882 | 280 | 1,281 | [
"DDInter1151",
"DDInter1070"
] | Mephentermine | Linagliptin | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
280,
24,
1281
]
],
[
[
280,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
280,
40,
1529
],
[
1529,
24,
1281
]
],
[
[
280,
74,
73
],
[
73,
... | [
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Mephentermine (Compound) resembles Metamfetamine (Compound) and Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00445 | DB11952 | 322 | 800 | [
"DDInter655",
"DDInter612"
] | Epirubicin | Duvelisib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
322,
24,
800
]
],
[
[
322,
24,
467
],
[
467,
24,
800
]
],
[
[
322,
24,
1476
],
[
1476,
63,
800
]
],
[
[
322,
63,
440
],
[
440,
2... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Briga... |
DB01128 | DB01166 | 918 | 477 | [
"DDInter204",
"DDInter379"
] | Bicalutamide | Cilostazol | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
918,
24,
477
]
],
[
[
918,
6,
8374
],
[
8374,
45,
477
]
],
[
[
918,
21,
28919
],
[
28919,
60,
477
]
],
[
[
918,
62,
112
],
[
112,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Bicalutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Bicalutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Bicalutamide (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole a... |
DB01017 | DB01144 | 1,669 | 1,326 | [
"DDInter1224",
"DDInter540"
] | Minocycline | Diclofenamide | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Minor | 0 | [
[
[
1669,
23,
1326
]
],
[
[
1669,
62,
504
],
[
504,
1,
1326
]
],
[
[
1669,
62,
359
],
[
359,
40,
1326
]
],
[
[
1669,
23,
674
],
[
674,
... | [
[
[
"Minocycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Diclofenamide"
]
],
[
[
"Minocycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrochlorothiazide"
]... | Minocycline may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Diclofenamide (Compound)
Minocycline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resem... |
DB00193 | DB06589 | 534 | 1,250 | [
"DDInter1841",
"DDInter1400"
] | Tramadol | Pazopanib | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
534,
24,
1250
]
],
[
[
534,
6,
12523
],
[
12523,
45,
1250
]
],
[
[
534,
18,
20113
],
[
20113,
46,
1250
]
],
[
[
534,
7,
2652
],
[
2652... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Tramadol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Tramadol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pazopanib (Compound)
Tramadol (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Pazopanib (Compound)
Tramadol (Compound) upregulates CASP10 (Gene) and CASP10 (Gene) is downregulated by Pazopanib (Compound)
Tramadol (Compound) cau... |
DB00673 | DB11560 | 723 | 1,678 | [
"DDInter112",
"DDInter1038"
] | Aprepitant | Lesinurad | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Moderate | 1 | [
[
[
723,
24,
1678
]
],
[
[
723,
63,
168
],
[
168,
23,
1678
]
],
[
[
723,
23,
466
],
[
466,
63,
1678
]
],
[
[
723,
63,
522
],
[
522,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lesinurad"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Lesinurad
Aprepitant may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutam... |
DB01041 | DB09128 | 770 | 1,241 | [
"DDInter1789",
"DDInter231"
] | Thalidomide | Brexpiprazole | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
770,
24,
1241
]
],
[
[
770,
24,
129
],
[
129,
24,
1241
]
],
[
[
770,
24,
407
],
[
407,
63,
1241
]
],
[
[
770,
63,
506
],
[
506,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Opium and Op... |
DB00434 | DB08918 | 13 | 41 | [
"DDInter459",
"DDInter1059"
] | Cyproheptadine | Levomilnacipran | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
13,
24,
41
]
],
[
[
13,
24,
901
],
[
901,
40,
41
]
],
[
[
13,
6,
7390
],
[
7390,
45,
41
]
],
[
[
13,
21,
28975
],
[
28975,
60,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Cyproheptadine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Levomilnacipran (Compound)
Cyproheptadine (Compound) causes Tension (Side... |
DB01181 | DB05679 | 1,532 | 1,683 | [
"DDInter906",
"DDInter1907"
] | Ifosfamide | Ustekinumab | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1532,
24,
1683
]
],
[
[
1532,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
1532,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
1532,
63,
1001
],
[
10... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib ma... |
DB00357 | DB00834 | 1,051 | 932 | [
"DDInter71",
"DDInter1215"
] | Aminoglutethimide | Mifepristone | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Moderate | 1 | [
[
[
1051,
24,
932
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
932
]
],
[
[
1051,
21,
28762
],
[
28762,
60,
932
]
],
[
[
1051,
62,
1101
],
[
1101... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mifepristone"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by ... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mifepristone (Compound)
Aminoglutethimide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken wit... |
DB00991 | DB09418 | 97 | 554 | [
"DDInter1358",
"DDInter1501"
] | Oxaprozin | Potassium perchlorate | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers has b... | Moderate | 1 | [
[
[
97,
24,
554
]
],
[
[
97,
63,
1274
],
[
1274,
24,
554
]
],
[
[
97,
24,
848
],
[
848,
24,
554
]
],
[
[
97,
63,
1274
],
[
1274,
24,... | [
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium perchlorate"
]
],
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofe... |
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