drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00554 | DB09075 | 1,027 | 498 | [
"DDInter1478",
"DDInter621"
] | Piroxicam | Edoxaban | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
1027,
25,
498
]
],
[
[
1027,
24,
222
],
[
222,
24,
498
]
],
[
[
1027,
24,
1017
],
[
1017,
63,
498
]
],
[
[
1027,
63,
305
],
[
305,
... | [
[
[
"Piroxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramine",... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatin... |
DB00218 | DB06655 | 1,176 | 5 | [
"DDInter1247",
"DDInter1077"
] | Moxifloxacin | Liraglutide | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1176,
24,
5
]
],
[
[
1176,
25,
870
],
[
870,
24,
5
]
],
[
[
1176,
24,
480
],
[
480,
24,
5
]
],
[
[
1176,
64,
176
],
[
176,
24,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludrocortisone"
],
[
"... | Moxifloxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formot... |
DB00514 | DB01121 | 506 | 94 | [
"DDInter527",
"DDInter1437"
] | Dextromethorphan | Phenacemide | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. | Moderate | 1 | [
[
[
506,
24,
94
]
],
[
[
506,
24,
1529
],
[
1529,
40,
94
]
],
[
[
506,
63,
73
],
[
73,
1,
94
]
],
[
[
506,
63,
80
],
[
80,
40,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Phenacemide (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine (Compound) resembles P... |
DB01619 | DB13913 | 830 | 1,536 | [
"DDInter1441",
"DDInter175"
] | Phenindamine | Belladonna | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
830,
24,
1536
]
],
[
[
830,
24,
849
],
[
849,
24,
1536
]
],
[
[
830,
63,
128
],
[
128,
24,
1536
]
],
[
[
830,
40,
104
],
[
104,
... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramin... |
DB00836 | DB06589 | 543 | 1,250 | [
"DDInter1088",
"DDInter1400"
] | Loperamide | Pazopanib | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
543,
24,
1250
]
],
[
[
543,
6,
3486
],
[
3486,
45,
1250
]
],
[
[
543,
18,
4729
],
[
4729,
46,
1250
]
],
[
[
543,
7,
17513
],
[
17513,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Loperamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Loperamide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Pazopanib (Compound)
Loperamide (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is upregulated by Pazopanib (Compound)
Loperamide (Compound) upregulates SLC35A1 (Gene) and SLC35A1 (Gene) is downregulated by Pazopanib (Compound)
Loperam... |
DB00270 | DB01246 | 1,428 | 820 | [
"DDInter993",
"DDInter45"
] | Isradipine | Alimemazine | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1428,
24,
820
]
],
[
[
1428,
24,
104
],
[
104,
40,
820
]
],
[
[
1428,
24,
401
],
[
401,
24,
820
]
],
[
[
1428,
6,
8374
],
[
8374,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB00472 | DB01181 | 758 | 1,532 | [
"DDInter758",
"DDInter906"
] | Fluoxetine | Ifosfamide | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
758,
24,
1532
]
],
[
[
758,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
758,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
758,
63,
1648
],
[
1648,... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Fluoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",... | Fluoxetine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Fluoxetine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin a... |
DB01193 | DB08884 | 819 | 796 | [
"DDInter12",
"DDInter800"
] | Acebutolol | Gadoxetic acid | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up ... | Moderate | 1 | [
[
[
819,
24,
796
]
],
[
[
819,
63,
457
],
[
457,
1,
796
]
],
[
[
819,
24,
1106
],
[
1106,
1,
796
]
],
[
[
819,
21,
28841
],
[
28841,
... | [
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoxetic acid"
]
],
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadodiamide"
],
... | Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Gadodiamide and Gadodiamide (Compound) resembles Gadoxetic acid (Compound)
Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Gadofosveset trisodium and Gadofosveset trisodium (Compound) re... |
DB01367 | DB09082 | 1,163 | 659 | [
"DDInter1572",
"DDInter1934"
] | Rasagiline | Vilanterol | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1163,
24,
659
]
],
[
[
1163,
24,
1296
],
[
1296,
63,
659
]
],
[
[
1163,
64,
222
],
[
222,
24,
659
]
],
[
[
1163,
63,
959
],
[
959,
... | [
[
[
"Rasagiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Rasagiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
],
... | Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Rasagiline may lead to a major life threatening interaction when taken with Sibutramine and Sibutram... |
DB00073 | DB10316 | 1,394 | 334 | [
"DDInter1608",
"DDInter1248"
] | Rituximab | Mumps virus strain B level jeryl lynn live antigen | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1394,
25,
334
]
],
[
[
1394,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1394,
25,
908
],
[
908,
25,
334
]
],
[
[
1394,
24,
599
],
[
599,
... | [
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
],
... | Rituximab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Rituximab may lead to a major life threatening interaction when taken with Golimumab and Golimumab may ... |
DB03754 | DB14006 | 1,400 | 972 | [
"DDInter1883",
"DDInter370"
] | Tromethamine | Choline salicylate | An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th e... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1400,
24,
972
]
],
[
[
1400,
62,
1411
],
[
1411,
24,
972
]
],
[
[
1400,
62,
663
],
[
663,
25,
972
]
],
[
[
1400,
62,
1411
],
[
1411,
... | [
[
[
"Tromethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Tromethamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolbutamide"
... | Tromethamine may cause a minor interaction that can limit clinical effects when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Tromethamine may cause a minor interaction that can limit clinical effects when taken with Methotrexat... |
DB00397 | DB01156 | 1,466 | 593 | [
"DDInter1458",
"DDInter252"
] | Phenylpropanolamine | Bupropion | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
1466,
25,
593
]
],
[
[
1466,
5,
11585
],
[
11585,
44,
593
]
],
[
[
1466,
6,
7950
],
[
7950,
45,
593
]
],
[
[
1466,
18,
2811
],
[
2811,... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) treats {v} (Disease)",
"obesity"
],
[
"obesity",
"{u} (Disease) is treated by {v}... | Phenylpropanolamine (Compound) treats obesity (Disease) and obesity (Disease) is treated by Bupropion (Compound)
Phenylpropanolamine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Bupropion (Compound)
Phenylpropanolamine (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Bupropion ... |
DB01169 | DB09268 | 57 | 1,662 | [
"DDInter120",
"DDInter1464"
] | Arsenic trioxide | Picosulfuric acid | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Major | 2 | [
[
[
57,
25,
1662
]
],
[
[
57,
64,
1164
],
[
1164,
24,
1662
]
],
[
[
57,
25,
484
],
[
484,
63,
1662
]
],
[
[
57,
25,
1618
],
[
1618,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimipramine"
],
[
"Trim... | Arsenic trioxide may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Arsenic trioxide may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib ... |
DB00069 | DB08901 | 367 | 1,468 | [
"DDInter946",
"DDInter1492"
] | Interferon alfacon-1 | Ponatinib | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
367,
24,
1468
]
],
[
[
367,
24,
589
],
[
589,
24,
1468
]
],
[
[
367,
63,
268
],
[
268,
24,
1468
]
],
[
[
367,
24,
384
],
[
384,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplati... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Pegi... |
DB00108 | DB00791 | 1,066 | 132 | [
"DDInter1268",
"DDInter1902"
] | Natalizumab | Uracil mustard | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Major | 2 | [
[
[
1066,
25,
132
]
],
[
[
1066,
25,
970
],
[
970,
40,
132
]
],
[
[
1066,
24,
1430
],
[
1430,
63,
132
]
],
[
[
1066,
25,
259
],
[
259,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Uracil mustard"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluorouracil"
],
[
"Fluorouracil",
... | Natalizumab may lead to a major life threatening interaction when taken with Fluorouracil and Fluorouracil (Compound) resembles Uracil mustard (Compound)
Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could ... |
DB00912 | DB08815 | 473 | 154 | [
"DDInter1581",
"DDInter1104"
] | Repaglinide | Lurasidone | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
473,
24,
154
]
],
[
[
473,
6,
8374
],
[
8374,
45,
154
]
],
[
[
473,
21,
29402
],
[
29402,
60,
154
]
],
[
[
473,
24,
1033
],
[
1033,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Repaglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Repaglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lurasidone (Compound)
Repaglinide (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Lurasidone (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when tak... |
DB00443 | DB04865 | 251 | 4 | [
"DDInter195",
"DDInter1335"
] | Betamethasone | Omacetaxine mepesuccinate | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
251,
24,
4
]
],
[
[
251,
18,
11089
],
[
11089,
46,
4
]
],
[
[
251,
7,
2384
],
[
2384,
46,
4
]
],
[
[
251,
6,
1899
],
[
1899,
46,... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Betamethasone",
"{u} (Compound) downregulates {v} (Gene)",
"DUSP8"
],
[
"DUSP8",
"{u} (Gene) i... | Betamethasone (Compound) downregulates DUSP8 (Gene) and DUSP8 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Betamethasone (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Betamethasone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is upregulated ... |
DB00843 | DB01110 | 479 | 86 | [
"DDInter583",
"DDInter1209"
] | Donepezil | Miconazole | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Minor | 0 | [
[
[
479,
23,
86
]
],
[
[
479,
6,
6017
],
[
6017,
45,
86
]
],
[
[
479,
18,
2183
],
[
2183,
57,
86
]
],
[
[
479,
21,
28666
],
[
28666,
... | [
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Miconazole"
]
],
[
[
"Donepezil",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Donepezil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Miconazole (Compound)
Donepezil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Miconazole (Compound)
Donepezil (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by... |
DB00705 | DB01410 | 441 | 423 | [
"DDInter496",
"DDInter376"
] | Delavirdine | Ciclesonide (nasal) | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Ciclesonide is an organic molecular entity. | Moderate | 1 | [
[
[
441,
24,
423
]
],
[
[
441,
63,
1573
],
[
1573,
1,
423
]
],
[
[
441,
63,
1351
],
[
1351,
40,
423
]
],
[
[
441,
25,
1486
],
[
1486,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ciclesonide"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Ciclesonide
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Delavirdine may cause a moderate interaction that coul... |
DB00011 | DB00911 | 1,451 | 458 | [
"DDInter944",
"DDInter1811"
] | Interferon alfa-n1 | Tinidazole | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
1451,
24,
458
]
],
[
[
1451,
24,
112
],
[
112,
1,
458
]
],
[
[
1451,
24,
238
],
[
238,
24,
458
]
],
[
[
1451,
24,
310
],
[
310,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazo... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol and Ethambutol may cause a moderate ... |
DB00601 | DB01611 | 453 | 1,487 | [
"DDInter1073",
"DDInter893"
] | Linezolid | Hydroxychloroquine | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
453,
24,
1487
]
],
[
[
453,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
453,
63,
168
],
[
168,
24,
1487
]
],
[
[
453,
24,
458
],
[
458,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Linezolid",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is ... | Linezolid (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Hyd... |
DB00831 | DB01309 | 1,178 | 1,254 | [
"DDInter1866",
"DDInter933"
] | Trifluoperazine | Insulin glulisine | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1178,
24,
1254
]
],
[
[
1178,
64,
1621
],
[
1621,
23,
1254
]
],
[
[
1178,
63,
274
],
[
274,
23,
1254
]
],
[
[
1178,
63,
1424
],
[
1424... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Trifluoperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]... | Trifluoperazine may lead to a major life threatening interaction when taken with Potassium chloride and Potassium chloride may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Phent... |
DB00708 | DB01362 | 1,454 | 497 | [
"DDInter1718",
"DDInter960"
] | Sufentanil | Iohexol | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1454,
25,
497
]
],
[
[
1454,
21,
29750
],
[
29750,
60,
497
]
],
[
[
1454,
63,
999
],
[
999,
25,
497
]
],
[
[
1454,
1,
704
],
[
704,
... | [
[
[
"Sufentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Sufentanil",
"{u} (Compound) causes {v} (Side Effect)",
"Injection site pain"
],
[
"Injection site pain",
"{u} (Side Effect) is ca... | Sufentanil (Compound) causes Injection site pain (Side Effect) and Injection site pain (Side Effect) is caused by Iohexol (Compound)
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction when take... |
DB00682 | DB06206 | 126 | 1,268 | [
"DDInter1951",
"DDInter1719"
] | Warfarin | Sugammadex | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Moderate | 1 | [
[
[
126,
24,
1268
]
],
[
[
126,
63,
11
],
[
11,
24,
1268
]
],
[
[
126,
64,
291
],
[
291,
24,
1268
]
],
[
[
126,
25,
1409
],
[
1409,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sugammadex"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Sugammadex
Warfarin may lead to a major life threatening interaction when taken with Argatroban and Argatroban may cause a mo... |
DB01149 | DB04845 | 851 | 309 | [
"DDInter1274",
"DDInter1001"
] | Nefazodone | Ixabepilone | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
851,
24,
309
]
],
[
[
851,
6,
8374
],
[
8374,
45,
309
]
],
[
[
851,
21,
28736
],
[
28736,
60,
309
]
],
[
[
851,
63,
60
],
[
60,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Nefazodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Nefazodone (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone (Compound)
Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine ... |
DB00446 | DB09083 | 597 | 880 | [
"DDInter351",
"DDInter996"
] | Chloramphenicol | Ivabradine | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Moderate | 1 | [
[
[
597,
24,
880
]
],
[
[
597,
25,
1478
],
[
1478,
24,
880
]
],
[
[
597,
24,
159
],
[
159,
63,
880
]
],
[
[
597,
24,
522
],
[
522,
2... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivabradine"
]
],
[
[
"Chloramphenicol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"I... | Chloramphenicol may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrecti... |
DB00414 | DB00726 | 590 | 1,164 | [
"DDInter16",
"DDInter1876"
] | Acetohexamide | Trimipramine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
590,
24,
1164
]
],
[
[
590,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
590,
63,
21
],
[
21,
40,
1164
]
],
[
[
590,
24,
1674
],
[
1674,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Trim... |
DB01591 | DB09020 | 667 | 28 | [
"DDInter1696",
"DDInter212"
] | Solifenacin | Bisacodyl | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
667,
24,
28
]
],
[
[
667,
63,
662
],
[
662,
1,
28
]
],
[
[
667,
63,
128
],
[
128,
40,
28
]
],
[
[
667,
21,
28666
],
[
28666,
60,... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles... |
DB01041 | DB12267 | 770 | 1,476 | [
"DDInter1789",
"DDInter233"
] | Thalidomide | Brigatinib | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
770,
24,
1476
]
],
[
[
770,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
770,
63,
168
],
[
168,
23,
1476
]
],
[
[
770,
63,
1184
],
[
1184,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bort... |
DB00603 | DB06203 | 303 | 1,002 | [
"DDInter1137",
"DDInter51"
] | Medroxyprogesterone acetate | Alogliptin | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
303,
24,
1002
]
],
[
[
303,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
303,
6,
8374
],
[
8374,
45,
1002
]
],
[
[
303,
21,
29321
],
[
29321,... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Medroxyprogesterone acetate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alogliptin (Compound)
Medroxyprogesterone acetate (C... |
DB00252 | DB08907 | 362 | 1,344 | [
"DDInter1460",
"DDInter280"
] | Phenytoin | Canagliflozin | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
362,
24,
1344
]
],
[
[
362,
6,
5912
],
[
5912,
45,
1344
]
],
[
[
362,
21,
28962
],
[
28962,
60,
1344
]
],
[
[
362,
25,
1033
],
[
1033,... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)",
... | Phenytoin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Canagliflozin (Compound)
Phenytoin (Compound) causes Hyperkalaemia (Side Effect) and Hyperkalaemia (Side Effect) is caused by Canagliflozin (Compound)
Phenytoin may lead to a major life threatening interaction when taken with Alpelisib and Alpelisib m... |
DB00046 | DB00876 | 1,179 | 1,414 | [
"DDInter940",
"DDInter658"
] | Insulin lispro | Eprosartan | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | Moderate | 1 | [
[
[
1179,
24,
1414
]
],
[
[
1179,
24,
240
],
[
240,
40,
1414
]
],
[
[
1179,
24,
629
],
[
629,
63,
1414
]
],
[
[
1179,
24,
175
],
[
175,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Eprosartan (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that cou... |
DB08870 | DB08916 | 850 | 26 | [
"DDInter228",
"DDInter32"
] | Brentuximab vedotin | Afatinib | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
850,
24,
26
]
],
[
[
850,
63,
883
],
[
883,
40,
26
]
],
[
[
850,
63,
651
],
[
651,
24,
26
]
],
[
[
850,
24,
996
],
[
996,
24,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin may cause a moderate inte... |
DB00679 | DB01233 | 684 | 1,311 | [
"DDInter1796",
"DDInter1197"
] | Thioridazine | Metoclopramide | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Major | 2 | [
[
[
684,
25,
1311
]
],
[
[
684,
25,
1151
],
[
1151,
40,
1311
]
],
[
[
684,
64,
1425
],
[
1425,
40,
1311
]
],
[
[
684,
6,
12523
],
[
12523,... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
]
],
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
],
[
"Sunitinib",
... | Thioridazine may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Thioridazine may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Metoclopramide (Compound)
Thioridazine (Compound... |
DB00358 | DB00694 | 1,010 | 51 | [
"DDInter1140",
"DDInter485"
] | Mefloquine | Daunorubicin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Moderate | 1 | [
[
[
1010,
24,
51
]
],
[
[
1010,
6,
4973
],
[
4973,
45,
51
]
],
[
[
1010,
7,
5998
],
[
5998,
57,
51
]
],
[
[
1010,
18,
2183
],
[
2183,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Daunorubicin (Compound)
Mefloquine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is downregulated by Daunorubicin (Compound)
Mefloquine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Daunorubicin (Compound)
Mefloqui... |
DB00900 | DB01073 | 45 | 1,488 | [
"DDInter544",
"DDInter745"
] | Didanosine | Fludarabine | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
45,
24,
1488
]
],
[
[
45,
63,
372
],
[
372,
1,
1488
]
],
[
[
45,
6,
6882
],
[
6882,
45,
1488
]
],
[
[
45,
21,
28701
],
[
28701,
... | [
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Didanosine (Compound) binds SLC29A1 (Gene) and SLC29A1 (Gene) is bound by Fludarabine (Compound)
Didanosine (Compound) causes Discomfort (Side Effect) and Di... |
DB00620 | DB01339 | 175 | 728 | [
"DDInter1855",
"DDInter1922"
] | Triamcinolone | Vecuronium | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide ad... | Moderate | 1 | [
[
[
175,
24,
728
]
],
[
[
175,
24,
1610
],
[
1610,
1,
728
]
],
[
[
175,
24,
1579
],
[
1579,
40,
728
]
],
[
[
175,
21,
28642
],
[
28642,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vecuronium"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rocuronium"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium and Rocuronium (Compound) resembles Vecuronium (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium and Pancuronium (Compound) resembles Vecuronium (Co... |
DB00373 | DB00852 | 461 | 1,445 | [
"DDInter1809",
"DDInter1545"
] | Timolol | Pseudoephedrine | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
461,
24,
1445
]
],
[
[
461,
24,
22
],
[
22,
40,
1445
]
],
[
[
461,
6,
12523
],
[
12523,
45,
1445
]
],
[
[
461,
21,
28763
],
[
28763,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine (Compound) resembles Pseudoephedrine (Compound)
Timolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pseudoephedrine (Compound)
Timolol (Compound) causes Chest pain (Side Effect) and Chest pai... |
DB00104 | DB00204 | 966 | 228 | [
"DDInter1323",
"DDInter580"
] | Octreotide | Dofetilide | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Moderate | 1 | [
[
[
966,
24,
228
]
],
[
[
966,
24,
540
],
[
540,
1,
228
]
],
[
[
966,
21,
28695
],
[
28695,
60,
228
]
],
[
[
966,
25,
1101
],
[
1101,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dofetilide"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Dofetilide (Compound)
Octreotide (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Dofetilide (Compound)
Octreotide may lead to a major life threaten... |
DB04845 | DB09498 | 309 | 810 | [
"DDInter1001",
"DDInter1715"
] | Ixabepilone | Strontium chloride Sr-89 | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
309,
24,
810
]
],
[
[
309,
63,
1555
],
[
1555,
24,
810
]
],
[
[
309,
62,
60
],
[
60,
24,
810
]
],
[
[
309,
24,
1060
],
[
1060,
6... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Ixabepilone may cause a minor interaction that can limit clinical effects when taken with Capec... |
DB00348 | DB14568 | 254 | 982 | [
"DDInter1300",
"DDInter1000"
] | Nitisinone | Ivosidenib | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
254,
24,
982
]
],
[
[
254,
63,
1101
],
[
1101,
23,
982
]
],
[
[
254,
24,
1247
],
[
1247,
23,
982
]
],
[
[
254,
24,
1478
],
[
1478,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Su... |
DB00358 | DB00532 | 1,010 | 208 | [
"DDInter1140",
"DDInter1152"
] | Mefloquine | Mephenytoin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
1010,
24,
208
]
],
[
[
1010,
63,
608
],
[
608,
23,
208
]
],
[
[
1010,
24,
770
],
[
770,
63,
208
]
],
[
[
1010,
25,
1487
],
[
1487,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Mephenytoin
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidom... |
DB00342 | DB00889 | 1,181 | 1,133 | [
"DDInter1770",
"DDInter840"
] | Terfenadine | Granisetron | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
1181,
24,
1133
]
],
[
[
1181,
23,
112
],
[
112,
62,
1133
]
],
[
[
1181,
24,
307
],
[
307,
23,
1133
]
],
[
[
1181,
24,
1213
],
[
1213,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Granisetron
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Mo... |
DB00060 | DB00313 | 912 | 556 | [
"DDInter947",
"DDInter1913"
] | Interferon beta-1a | Valproic acid | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Moderate | 1 | [
[
[
912,
24,
556
]
],
[
[
912,
24,
1686
],
[
1686,
62,
556
]
],
[
[
912,
24,
168
],
[
168,
23,
556
]
],
[
[
912,
24,
267
],
[
267,
6... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valproic acid"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temozolo... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Temozolomide and Temozolomide may cause a minor interaction that can limit clinical effects when taken with Valproic acid
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB08880 | DB11834 | 1,510 | 1,303 | [
"DDInter1771",
"DDInter849"
] | Teriflunomide | Guselkumab | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Major | 2 | [
[
[
1510,
25,
1303
]
],
[
[
1510,
23,
1193
],
[
1193,
23,
1303
]
],
[
[
1510,
62,
1461
],
[
1461,
23,
1303
]
],
[
[
1510,
24,
949
],
[
949... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Guselkumab"
]
],
[
[
"Teriflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zi... | Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Guselkumab
Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and... |
DB08820 | DB09073 | 1,478 | 951 | [
"DDInter997",
"DDInter1379"
] | Ivacaftor | Palbociclib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1478,
24,
951
]
],
[
[
1478,
23,
907
],
[
907,
62,
951
]
],
[
[
1478,
62,
318
],
[
318,
23,
951
]
],
[
[
1478,
23,
271
],
[
271,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Ivacaftor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[
... | Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Escitalopram and Escitalopra... |
DB01246 | DB01579 | 820 | 341 | [
"DDInter45",
"DDInter1439"
] | Alimemazine | Phendimetrazine | A phenothiazine derivative that is used as an antipruritic. | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Moderate | 1 | [
[
[
820,
24,
341
]
],
[
[
820,
21,
28662
],
[
28662,
60,
341
]
],
[
[
820,
63,
959
],
[
959,
24,
341
]
],
[
[
820,
24,
1281
],
[
1281,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Alimemazine",
"{u} (Compound) causes {v} (Side Effect)",
"Tremor"
],
[
"Tremor",
"{u} (Side Effect) is cau... | Alimemazine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Phendimetrazine (Compound)
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Phendime... |
DB06637 | DB09472 | 1,109 | 1,383 | [
"DDInter468",
"DDInter1693"
] | Dalfampridine | Sodium sulfate | Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1109,
24,
1383
]
],
[
[
1109,
64,
593
],
[
593,
24,
1383
]
],
[
[
1109,
63,
1503
],
[
1503,
24,
1383
]
],
[
[
1109,
24,
351
],
[
351,
... | [
[
[
"Dalfampridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Dalfampridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
],
[
"B... | Dalfampridine may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Dalfampridine may cause a moderate interaction that could exacerbate diseases when taken with Lindane and Lindane may caus... |
DB01410 | DB13139 | 423 | 1,032 | [
"DDInter375",
"DDInter1063"
] | Ciclesonide | Levosalbutamol | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Minor | 0 | [
[
[
423,
23,
1032
]
],
[
[
423,
40,
218
],
[
218,
23,
1032
]
],
[
[
423,
1,
1486
],
[
1486,
23,
1032
]
],
[
[
423,
23,
659
],
[
659,
... | [
[
[
"Ciclesonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Ciclesonide",
"{u} (Compound) resembles {v} (Compound)",
"Beclomethasone dipropionate"
],
[
"Beclomethasone dipropi... | Ciclesonide (Compound) resembles Beclomethasone dipropionate (Compound) and Beclomethasone dipropionate may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Ciclesonide (Compound) resembles Methylprednisolone (Compound) and Methylprednisolone may cause a minor interaction that ca... |
DB00501 | DB00843 | 752 | 479 | [
"DDInter380",
"DDInter583"
] | Cimetidine | Donepezil | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
752,
24,
479
]
],
[
[
752,
6,
12523
],
[
12523,
45,
479
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],
[
[
752,
21,
28741
],
[
28741,
60,
479
]
],
[
[
752,
24,
723
],
[
723,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Cimetidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Cimetidine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Donepezil (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepi... |
DB01233 | DB08824 | 1,311 | 591 | [
"DDInter1197",
"DDInter959"
] | Metoclopramide | Ioflupane I-123 | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
1311,
24,
591
]
],
[
[
1311,
21,
28722
],
[
28722,
60,
591
]
],
[
[
1311,
63,
109
],
[
109,
24,
591
]
],
[
[
1311,
25,
924
],
[
924,
... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Metoclopramide",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) ... | Metoclopramide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ioflupane I-123 (Compound)
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB06228 | DB11166 | 792 | 18 | [
"DDInter1609",
"DDInter104"
] | Rivaroxaban | Antithrombin Alfa | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations. | Major | 2 | [
[
[
792,
25,
18
]
],
[
[
792,
63,
1595
],
[
1595,
24,
18
]
],
[
[
792,
24,
116
],
[
116,
24,
18
]
],
[
[
792,
64,
714
],
[
714,
24,
... | [
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Antithrombin Alfa"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Collagenase clostridium histolyti... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Collagenase clostridium histolyticum and Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Antithrombin Alfa
Rivaroxaban may cause a moderate interaction that co... |
DB00398 | DB01142 | 79 | 1,264 | [
"DDInter1702",
"DDInter593"
] | Sorafenib | Doxepin | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
79,
24,
1264
]
],
[
[
79,
24,
508
],
[
508,
24,
1264
]
],
[
[
79,
6,
4973
],
[
4973,
45,
1264
]
],
[
[
79,
7,
9384
],
[
9384,
57... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
"P... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Sorafenib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxepin (Compound)
Sorafenib (Compound) upregulat... |
DB00446 | DB00688 | 597 | 955 | [
"DDInter351",
"DDInter1251"
] | Chloramphenicol | Mycophenolate mofetil | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Moderate | 1 | [
[
[
597,
24,
955
]
],
[
[
597,
24,
1096
],
[
1096,
40,
955
]
],
[
[
597,
6,
3486
],
[
3486,
45,
955
]
],
[
[
597,
7,
5182
],
[
5182,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolate mofetil"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycoph... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid (Compound) resembles Mycophenolate mofetil (Compound)
Chloramphenicol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Mycophenolate mofetil (Compound)
Chloramphenicol (Com... |
DB09268 | DB12329 | 1,662 | 464 | [
"DDInter1464",
"DDInter660"
] | Picosulfuric acid | Eravacycline | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Eravacycline, known as _Xerava_ by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic of the tetracycline class with activity against clinically significant gram-negative, gram-positive aerobic, and facultative bacteria. This includes most of those bacteria resistant to cephalosporins, fluoroquin... | Moderate | 1 | [
[
[
1662,
24,
464
]
],
[
[
1662,
63,
609
],
[
609,
23,
464
]
],
[
[
1662,
24,
913
],
[
913,
25,
464
]
],
[
[
1662,
63,
129
],
[
129,
... | [
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eravacycline"
]
],
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromy... | Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Eravacycline
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00734 | DB01268 | 1,664 | 1,151 | [
"DDInter1605",
"DDInter1731"
] | Risperidone | Sunitinib | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1664,
24,
1151
]
],
[
[
1664,
25,
1311
],
[
1311,
1,
1151
]
],
[
[
1664,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
1664,
21,
29487
],
[
294... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Risperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
],
[
"Metoc... | Risperidone may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Risperidone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Risperidone (Compound) causes Cholecystitis (Side Effect) and Cholecystitis... |
DB08871 | DB11978 | 36 | 124 | [
"DDInter666",
"DDInter822"
] | Eribulin | Glasdegib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
36,
24,
124
]
],
[
[
36,
62,
1247
],
[
1247,
23,
124
]
],
[
[
36,
63,
112
],
[
112,
23,
124
]
],
[
[
36,
63,
1079
],
[
1079,
24,... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Eribulin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Eribulin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and ... |
DB00812 | DB08901 | 998 | 1,468 | [
"DDInter1451",
"DDInter1492"
] | Phenylbutazone | Ponatinib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
998,
25,
1468
]
],
[
[
998,
24,
478
],
[
478,
24,
1468
]
],
[
[
998,
6,
8374
],
[
8374,
45,
1468
]
],
[
[
998,
40,
307
],
[
307,
... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
"Nilo... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound)
Phenylbutazone... |
DB00902 | DB01018 | 104 | 1,364 | [
"DDInter1168",
"DDInter847"
] | Methdilazine | Guanfacine | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Moderate | 1 | [
[
[
104,
24,
1364
]
],
[
[
104,
63,
390
],
[
390,
1,
1364
]
],
[
[
104,
24,
549
],
[
549,
63,
1364
]
],
[
[
104,
63,
1214
],
[
1214,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanfacine"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanabenz"
],
[... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Guanabenz and Guanabenz (Compound) resembles Guanfacine (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction th... |
DB00317 | DB08912 | 883 | 1,040 | [
"DDInter810",
"DDInter462"
] | Gefitinib | Dabrafenib | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
883,
24,
1040
]
],
[
[
883,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
883,
7,
5653
],
[
5653,
46,
1040
]
],
[
[
883,
6,
6732
],
[
6732,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Gefitinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Gefitinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Gefitinib (Compound) upregulates AGL (Gene) and AGL (Gene) is upregulated by Dabrafenib (Compound)
Gefitinib (Compound) binds MAP2K5 (Gene) and MAP2K5 (Gene) is upregulated by Dabrafenib (Compound)
Gefitinib (Compound) downregula... |
DB00209 | DB01235 | 352 | 1,191 | [
"DDInter1886",
"DDInter1054"
] | Trospium | Levodopa | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
352,
24,
1191
]
],
[
[
352,
6,
12523
],
[
12523,
45,
1191
]
],
[
[
352,
21,
28936
],
[
28936,
60,
1191
]
],
[
[
352,
24,
1264
],
[
126... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Trospium",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Levodopa (Compound)
Trospium (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Levodopa (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin m... |
DB08912 | DB11828 | 1,040 | 1,406 | [
"DDInter462",
"DDInter1281"
] | Dabrafenib | Neratinib | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
1040,
25,
1406
]
],
[
[
1040,
24,
1135
],
[
1135,
23,
1406
]
],
[
[
1040,
63,
392
],
[
392,
24,
1406
]
],
[
[
1040,
64,
1197
],
[
1197... | [
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib ma... |
DB00609 | DB09564 | 595 | 1,296 | [
"DDInter694",
"DDInter930"
] | Ethionamide | Insulin degludec | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
595,
24,
1296
]
],
[
[
595,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
595,
63,
305
],
[
305,
24,
1296
]
],
[
[
595,
24,
1411
],
[
1411,
... | [
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],... | Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Asparaginas... |
DB00757 | DB00880 | 1,166 | 359 | [
"DDInter581",
"DDInter360"
] | Dolasetron | Chlorothiazide | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Major | 2 | [
[
[
1166,
25,
359
]
],
[
[
1166,
25,
1577
],
[
1577,
1,
359
]
],
[
[
1166,
64,
1014
],
[
1014,
1,
359
]
],
[
[
1166,
21,
28784
],
[
28784,... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroflumethiazide"
],
[
"Hydroflumethi... | Dolasetron may lead to a major life threatening interaction when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Benzthiazide and Benzthiazide (Compound) resembles Chlorothiazide (Compound)
Do... |
DB01234 | DB06237 | 1,220 | 438 | [
"DDInter513",
"DDInter141"
] | Dexamethasone | Avanafil | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual ... | Moderate | 1 | [
[
[
1220,
24,
438
]
],
[
[
1220,
6,
8374
],
[
8374,
45,
438
]
],
[
[
1220,
21,
29118
],
[
29118,
60,
438
]
],
[
[
1220,
63,
1051
],
[
1051... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avanafil"
]
],
[
[
"Dexamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Dexamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Avanafil (Compound)
Dexamethasone (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Avanafil (Compound)
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Aminoglute... |
DB00673 | DB01254 | 723 | 1,213 | [
"DDInter112",
"DDInter484"
] | Aprepitant | Dasatinib | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
723,
24,
1213
]
],
[
[
723,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
723,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
723,
23,
907
],
[
907,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Aprepitant (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Aprepitant may cause a minor interaction that can limit clinical effects when ... |
DB01224 | DB09098 | 623 | 98 | [
"DDInter1553",
"DDInter1700"
] | Quetiapine | Somatrem | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
623,
24,
98
]
],
[
[
623,
24,
159
],
[
159,
63,
98
]
],
[
[
623,
64,
11
],
[
11,
24,
98
]
],
[
[
623,
63,
1647
],
[
1647,
24,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Quetiapine may lead to a major life threatening interaction when taken with Toremifene and Toremifene may ca... |
DB01030 | DB08880 | 869 | 1,510 | [
"DDInter1835",
"DDInter1771"
] | Topotecan | Teriflunomide | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
869,
25,
1510
]
],
[
[
869,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
869,
24,
129
],
[
129,
63,
1510
]
],
[
[
869,
24,
1136
],
[
1136,
... | [
[
[
"Topotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalut... |
DB01299 | DB09420 | 698 | 1,074 | [
"DDInter1722",
"DDInter953"
] | Sulfadoxine | Iodide I-123 | A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
698,
24,
1074
]
],
[
[
698,
40,
161
],
[
161,
24,
1074
]
],
[
[
698,
64,
126
],
[
126,
24,
1074
]
],
[
[
698,
74,
10
],
[
10,
24... | [
[
[
"Sulfadoxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Sulfadoxine",
"{u} (Compound) resembles {v} (Compound)",
"Sulfadiazine"
],
[
"Sulfadiazine",
"{u} may cause a... | Sulfadoxine (Compound) resembles Sulfadiazine (Compound) and Sulfadiazine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Sulfadoxine may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate... |
DB00188 | DB00758 | 168 | 1,347 | [
"DDInter222",
"DDInter413"
] | Bortezomib | Clopidogrel | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Moderate | 1 | [
[
[
168,
24,
1347
]
],
[
[
168,
6,
3486
],
[
3486,
45,
1347
]
],
[
[
168,
7,
6917
],
[
6917,
46,
1347
]
],
[
[
168,
18,
2947
],
[
2947,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)"... | Bortezomib (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Clopidogrel (Compound)
Bortezomib (Compound) upregulates SNX13 (Gene) and SNX13 (Gene) is upregulated by Clopidogrel (Compound)
Bortezomib (Compound) downregulates DECR1 (Gene) and DECR1 (Gene) is downregulated by Clopidogrel (Compound)
Bortezomib ... |
DB01592 | DB09322 | 1,596 | 1,114 | [
"DDInter975",
"DDInter1966"
] | Iron | Zinc sulfate | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Minor | 0 | [
[
[
1596,
23,
1114
]
],
[
[
1596,
62,
955
],
[
955,
23,
1114
]
],
[
[
1596,
24,
29
],
[
29,
23,
1114
]
],
[
[
1596,
63,
1299
],
[
1299,
... | [
[
[
"Iron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Iron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mycophenolate mofetil"
],
[
... | Iron may cause a minor interaction that can limit clinical effects when taken with Mycophenolate mofetil and Mycophenolate mofetil may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Iron may cause a moderate interaction that could exacerbate diseases when taken with Triethylenete... |
DB08904 | DB09331 | 375 | 745 | [
"DDInter342",
"DDInter478"
] | Certolizumab pegol | Daratumumab | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for the trea... | Major | 2 | [
[
[
375,
25,
745
]
],
[
[
375,
64,
139
],
[
139,
24,
745
]
],
[
[
375,
63,
597
],
[
597,
24,
745
]
],
[
[
375,
25,
287
],
[
287,
63,... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Daratumumab"
]
],
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
[
"Zidovudi... | Certolizumab pegol may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Daratumumab
Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and... |
DB00860 | DB01276 | 891 | 123 | [
"DDInter1513",
"DDInter706"
] | Prednisolone | Exenatide | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
891,
24,
123
]
],
[
[
891,
63,
1252
],
[
1252,
23,
123
]
],
[
[
891,
40,
1103
],
[
1103,
23,
123
]
],
[
[
891,
23,
1072
],
[
1072,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Exenatide
Prednisolone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit cli... |
DB00682 | DB01250 | 126 | 712 | [
"DDInter1951",
"DDInter1334"
] | Warfarin | Olsalazine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Minor | 0 | [
[
[
126,
23,
712
]
],
[
[
126,
25,
50
],
[
50,
40,
712
]
],
[
[
126,
1,
345
],
[
345,
1,
712
]
],
[
[
126,
25,
914
],
[
914,
24,
... | [
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Olsalazine"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfasalazine"
],
[
"Sulfasalazine... | Warfarin may lead to a major life threatening interaction when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Warfarin (Compound) resembles Salsalate (Compound) and Salsalate (Compound) resembles Olsalazine (Compound)
Warfarin may lead to a major life threatening interaction when ... |
DB00029 | DB00055 | 25 | 834 | [
"DDInter99",
"DDInter605"
] | Anistreplase | Drotrecogin alfa | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Major | 2 | [
[
[
25,
25,
834
]
],
[
[
25,
23,
539
],
[
539,
62,
834
]
],
[
[
25,
24,
318
],
[
318,
63,
834
]
],
[
[
25,
25,
1226
],
[
1226,
64,
... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Drotrecogin alfa"
]
],
[
[
"Anistreplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Caps... | Anistreplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Drotrecogin alfa
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Es... |
DB01088 | DB01089 | 714 | 1,340 | [
"DDInter908",
"DDInter502"
] | Iloprost | Deserpidine | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | Moderate | 1 | [
[
[
714,
24,
1340
]
],
[
[
714,
63,
1245
],
[
1245,
40,
1340
]
],
[
[
714,
63,
1445
],
[
1445,
24,
1340
]
],
[
[
714,
24,
1455
],
[
1455,
... | [
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deserpidine"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Reserpine"
],
[
... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Reserpine and Reserpine (Compound) resembles Deserpidine (Compound)
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that ... |
DB06663 | DB09351 | 1,154 | 722 | [
"DDInter1398",
"DDInter1048"
] | Pasireotide | Levobetaxolol (ophthalmic) | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | (S)-betaxolol is the (S)-enantiomer of betaxolol. It is an enantiomer of a (R)-betaxolol. | Moderate | 1 | [
[
[
1154,
24,
722
]
],
[
[
1154,
25,
1593
],
[
1593,
24,
722
]
],
[
[
1154,
63,
770
],
[
770,
24,
722
]
],
[
[
1154,
1,
966
],
[
966,
... | [
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levobetaxolol"
]
],
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizo... | Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Levobetaxolol
Pasireotide may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Levobetaxolol
Pasireotide may c... |
DB04868 | DB11915 | 478 | 1,293 | [
"DDInter1293",
"DDInter1909"
] | Nilotinib | Valbenazine | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Major | 2 | [
[
[
478,
25,
1293
]
],
[
[
478,
62,
112
],
[
112,
23,
1293
]
],
[
[
478,
24,
710
],
[
710,
63,
1293
]
],
[
[
478,
64,
521
],
[
521,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Valbenazine"
]
],
[
[
"Nilotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Nilotinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Bini... |
DB06595 | DB10429 | 1,491 | 200 | [
"DDInter1214",
"DDInter282"
] | Midostaurin | Candida albicans | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1491,
24,
200
]
],
[
[
1491,
63,
1683
],
[
1683,
24,
200
]
],
[
[
1491,
25,
976
],
[
976,
24,
200
]
],
[
[
1491,
24,
594
],
[
594,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Midostaurin may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitini... |
DB01501 | DB04837 | 1,118 | 649 | [
"DDInter549",
"DDInter407"
] | Difenoxin | Clofedanol | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1118,
24,
649
]
],
[
[
1118,
63,
1301
],
[
1301,
40,
649
]
],
[
[
1118,
40,
543
],
[
543,
40,
649
]
],
[
[
1118,
1,
1511
],
[
1511,
... | [
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levacetylmethadol"
],
... | Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Levacetylmethadol and Levacetylmethadol (Compound) resembles Clofedanol (Compound)
Difenoxin (Compound) resembles Loperamide (Compound) and Loperamide (Compound) resembles Clofedanol (Compound)
Difenoxin (Compound) resembles Mepen... |
DB00377 | DB05316 | 1,494 | 749 | [
"DDInter1382",
"DDInter1467"
] | Palonosetron | Pimavanserin | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Moderate | 1 | [
[
[
1494,
24,
749
]
],
[
[
1494,
23,
112
],
[
112,
23,
749
]
],
[
[
1494,
25,
1264
],
[
1264,
24,
749
]
],
[
[
1494,
24,
392
],
[
392,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimavanserin"
]
],
[
[
"Palonosetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimavanserin
Palonosetron may lead to a major life threatening interaction when taken with Doxepin and Doxepin may caus... |
DB04865 | DB09330 | 4 | 985 | [
"DDInter1335",
"DDInter1352"
] | Omacetaxine mepesuccinate | Osimertinib | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
4,
24,
985
]
],
[
[
4,
63,
168
],
[
168,
23,
985
]
],
[
[
4,
63,
134
],
[
134,
24,
985
]
],
[
[
4,
25,
1598
],
[
1598,
63,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when tak... |
DB00372 | DB00395 | 999 | 210 | [
"DDInter1793",
"DDInter301"
] | Thiethylperazine | Carisoprodol | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications . This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with ... | Moderate | 1 | [
[
[
999,
24,
210
]
],
[
[
999,
63,
1050
],
[
1050,
40,
210
]
],
[
[
999,
24,
1637
],
[
1637,
63,
210
]
],
[
[
999,
63,
701
],
[
701,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carisoprodol"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meprobamate"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Meprobamate and Meprobamate (Compound) resembles Carisoprodol (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite and Amyl Nitrite may cause a moderate in... |
DB00344 | DB14568 | 1,302 | 982 | [
"DDInter1543",
"DDInter1000"
] | Protriptyline | Ivosidenib | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1302,
25,
982
]
],
[
[
1302,
23,
112
],
[
112,
23,
982
]
],
[
[
1302,
24,
543
],
[
543,
24,
982
]
],
[
[
1302,
25,
11
],
[
11,
2... | [
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Protriptyline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Protriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Loperamide an... |
DB01281 | DB11003 | 881 | 748 | [
"DDInter5",
"DDInter100"
] | Abatacept | Anthrax vaccine | Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS mo... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
881,
24,
748
]
],
[
[
881,
25,
676
],
[
676,
63,
748
]
],
[
[
881,
24,
1683
],
[
1683,
24,
748
]
],
[
[
881,
64,
1057
],
[
1057,
... | [
[
[
"Abatacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Abatacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[
"Upada... | Abatacept may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Abatacept may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab m... |
DB00401 | DB01254 | 84 | 1,213 | [
"DDInter1298",
"DDInter484"
] | Nisoldipine | Dasatinib | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
84,
24,
1213
]
],
[
[
84,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
84,
7,
7478
],
[
7478,
46,
1213
]
],
[
[
84,
18,
2183
],
[
2183,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Nisoldipine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nisoldipine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Nisoldipine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Dasatinib (Compound)
Nisoldipine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dasatinib (Compound)
Nisoldipin... |
DB00981 | DB11640 | 1,528 | 1,267 | [
"DDInter1462",
"DDInter64"
] | Physostigmine | Amifampridine | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
1528,
24,
1267
]
],
[
[
1528,
63,
999
],
[
999,
24,
1267
]
],
[
[
1528,
24,
820
],
[
820,
24,
1267
]
],
[
[
1528,
25,
497
],
[
497,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00214 | DB01001 | 1,028 | 688 | [
"DDInter1836",
"DDInter1632"
] | Torasemide | Salbutamol | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1028,
24,
688
]
],
[
[
1028,
24,
455
],
[
455,
24,
688
]
],
[
[
1028,
21,
28714
],
[
28714,
60,
688
]
],
[
[
1028,
24,
1220
],
[
1220,... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Torasemide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Salbutamol (Compound... |
DB01024 | DB14520 | 1,096 | 1,229 | [
"DDInter1252",
"DDInter1785"
] | Mycophenolic acid | Tetraferric tricitrate decahydrate | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease. Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2014. | Minor | 0 | [
[
[
1096,
23,
1229
]
],
[
[
1096,
40,
955
],
[
955,
23,
1229
]
],
[
[
1096,
63,
954
],
[
954,
24,
1229
]
],
[
[
1096,
24,
246
],
[
246,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetraferric tricitrate decahydrate"
]
],
[
[
"Mycophenolic acid",
"{u} (Compound) resembles {v} (Compound)",
"Mycophenolate mofetil"
],
[
... | Mycophenolic acid (Compound) resembles Mycophenolate mofetil (Compound) and Mycophenolate mofetil may cause a minor interaction that can limit clinical effects when taken with Tetraferric tricitrate decahydrate
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Quinapril a... |
DB00065 | DB12240 | 581 | 110 | [
"DDInter923",
"DDInter1485"
] | Infliximab | Polatuzumab vedotin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Major | 2 | [
[
[
581,
25,
110
]
],
[
[
581,
24,
467
],
[
467,
24,
110
]
],
[
[
581,
25,
1419
],
[
1419,
24,
110
]
],
[
[
581,
63,
268
],
[
268,
2... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
"... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin
Infliximab may lead to a major life threatening interaction when taken with Imatinib and Imatinib may... |
DB00365 | DB00959 | 839 | 1,486 | [
"DDInter842",
"DDInter1191"
] | Grepafloxacin | Methylprednisolone | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Major | 2 | [
[
[
839,
25,
1486
]
],
[
[
839,
25,
175
],
[
175,
40,
1486
]
],
[
[
839,
25,
167
],
[
167,
1,
1486
]
],
[
[
839,
24,
617
],
[
617,
4... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcin... | Grepafloxacin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Grepafloxacin may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Methylprednisolone (Comp... |
DB01599 | DB08899 | 1,232 | 129 | [
"DDInter1523",
"DDInter649"
] | Probucol | Enzalutamide | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1232,
24,
129
]
],
[
[
1232,
63,
918
],
[
918,
1,
129
]
],
[
[
1232,
62,
112
],
[
112,
23,
129
]
],
[
[
1232,
63,
79
],
[
79,
24... | [
[
[
"Probucol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Probucol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
... | Probucol may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Probucol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that ca... |
DB00835 | DB11130 | 100 | 407 | [
"DDInter245",
"DDInter1344"
] | Brompheniramine | Opium | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
100,
24,
407
]
],
[
[
100,
63,
558
],
[
558,
24,
407
]
],
[
[
100,
24,
1190
],
[
1190,
24,
407
]
],
[
[
100,
74,
662
],
[
662,
2... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolpidem"
],
[... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Zolpidem and Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Opium
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ketamine and Ketamin... |
DB06403 | DB11581 | 1,204 | 1,456 | [
"DDInter62",
"DDInter1926"
] | Ambrisentan | Venetoclax | Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the Un... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
1204,
24,
1456
]
],
[
[
1204,
24,
1476
],
[
1476,
63,
1456
]
],
[
[
1204,
62,
86
],
[
86,
24,
1456
]
],
[
[
1204,
24,
1017
],
[
1017,
... | [
[
[
"Ambrisentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Ambrisentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Ambrisentan may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Ambrisentan may cause a minor interaction that can limit clinical effects when taken with Miconazole and Micona... |
DB00470 | DB00697 | 530 | 876 | [
"DDInter601",
"DDInter1821"
] | Dronabinol | Tizanidine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
530,
24,
876
]
],
[
[
530,
24,
1617
],
[
1617,
1,
876
]
],
[
[
530,
21,
29054
],
[
29054,
60,
876
]
],
[
[
530,
24,
401
],
[
401,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
[... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Tizanidine (Compound)
Dronabinol (Compound) causes Speech disorder (Side Effect) and Speech disorder (Side Effect) is caused by Tizanidine (Compound)
Dronabinol may cause a mod... |
DB00852 | DB06704 | 1,445 | 247 | [
"DDInter1545",
"DDInter952"
] | Pseudoephedrine | Iobenguane (I-131) | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
1445,
37,
247
]
],
[
[
1445,
6,
7390
],
[
7390,
45,
247
]
],
[
[
1445,
21,
28787
],
[
28787,
60,
247
]
],
[
[
1445,
63,
461
],
[
461,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Pseudoephedrine",
"{u} (Compound) binds {v} (Gene)",
... | Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Pseudoephedrine may lead to a major life threatening interaction when taken with Iobenguane
Pseudoephedrine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Pseudoephedrine (C... |
DB00361 | DB06317 | 134 | 1,626 | [
"DDInter1939",
"DDInter630"
] | Vinorelbine | Elotuzumab | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
134,
24,
1626
]
],
[
[
134,
24,
973
],
[
973,
24,
1626
]
],
[
[
134,
63,
1463
],
[
1463,
24,
1626
]
],
[
[
134,
24,
200
],
[
200,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lova... |
DB08827 | DB12010 | 990 | 214 | [
"DDInter1085",
"DDInter785"
] | Lomitapide | Fostamatinib | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
990,
25,
214
]
],
[
[
990,
64,
723
],
[
723,
24,
214
]
],
[
[
990,
63,
51
],
[
51,
24,
214
]
],
[
[
990,
24,
1362
],
[
1362,
24,... | [
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aprepitant"
],
[
"Aprepitant",
"{u}... | Lomitapide may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Lomitapide may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may ... |
DB00373 | DB09104 | 461 | 286 | [
"DDInter1809",
"DDInter1118"
] | Timolol | Magnesium hydroxide | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
461,
23,
286
]
],
[
[
461,
24,
820
],
[
820,
23,
286
]
],
[
[
461,
63,
999
],
[
999,
23,
286
]
],
[
[
461,
1,
729
],
[
729,
23,
... | [
[
[
"Timolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine a... |
DB00024 | DB01067 | 818 | 959 | [
"DDInter1800",
"DDInter826"
] | Thyrotropin alfa | Glipizide | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
818,
24,
959
]
],
[
[
818,
24,
245
],
[
245,
40,
959
]
],
[
[
818,
24,
1411
],
[
1411,
1,
959
]
],
[
[
818,
24,
433
],
[
433,
63... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizi... |
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