drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00491 | DB08870 | 127 | 850 | [
"DDInter1217",
"DDInter228"
] | Miglitol | Brentuximab vedotin | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
127,
24,
850
]
],
[
[
127,
24,
1142
],
[
1142,
24,
850
]
],
[
[
127,
24,
1033
],
[
1033,
63,
850
]
],
[
[
127,
63,
245
],
[
245,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
],
[... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpeli... |
DB01059 | DB01309 | 956 | 1,254 | [
"DDInter1313",
"DDInter933"
] | Norfloxacin | Insulin glulisine | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Major | 2 | [
[
[
956,
25,
1254
]
],
[
[
956,
63,
1424
],
[
1424,
24,
1254
]
],
[
[
956,
64,
167
],
[
167,
24,
1254
]
],
[
[
956,
25,
1220
],
[
1220,
... | [
[
[
"Norfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
"Quin... | Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Norfloxacin may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone... |
DB05812 | DB09128 | 1,374 | 1,241 | [
"DDInter8",
"DDInter231"
] | Abiraterone | Brexpiprazole | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Major | 2 | [
[
[
1374,
25,
1241
]
],
[
[
1374,
25,
129
],
[
129,
24,
1241
]
],
[
[
1374,
64,
543
],
[
543,
24,
1241
]
],
[
[
1374,
63,
506
],
[
506,
... | [
[
[
"Abiraterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Abiraterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Abiraterone may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Abiraterone may lead to a major life threatening interaction when taken with Loperamide and Loperamide may cause a mode... |
DB00261 | DB11113 | 702 | 657 | [
"DDInter93",
"DDInter307"
] | Anagrelide | Castor oil | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
702,
24,
657
]
],
[
[
702,
25,
1079
],
[
1079,
24,
657
]
],
[
[
702,
25,
927
],
[
927,
63,
657
]
],
[
[
702,
64,
534
],
[
534,
2... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telavancin"
],
[
"Telavancin... | Anagrelide may lead to a major life threatening interaction when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Anagrelide may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate in... |
DB11767 | DB14444 | 1,583 | 151 | [
"DDInter1643",
"DDInter924"
] | Sarilumab | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1583,
24,
151
]
],
[
[
1583,
63,
66
],
[
66,
24,
151
]
],
[
[
1583,
64,
1394
],
[
1394,
24,
151
]
],
[
[
1583,
24,
738
],
[
738,
... | [
[
[
"Sarilumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Sarilumab",
"{u} may cause a moderate interaction that could exa... | Sarilumab may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Sarilumab may lead to a major life thr... |
DB00747 | DB00761 | 1,442 | 1,621 | [
"DDInter1647",
"DDInter1497"
] | Scopolamine | Potassium chloride | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
1442,
25,
1621
]
],
[
[
1442,
21,
28929
],
[
28929,
60,
1621
]
],
[
[
1442,
63,
1105
],
[
1105,
25,
1621
]
],
[
[
1442,
24,
667
],
[
6... | [
[
[
"Scopolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Scopolamine",
"{u} (Compound) causes {v} (Side Effect)",
"Confusional state"
],
[
"Confusional state",
"{u} (Side Effe... | Scopolamine (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Potassium chloride (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl may lead to a major life threatening interaction wh... |
DB01601 | DB11110 | 833 | 603 | [
"DDInter1089",
"DDInter1115"
] | Lopinavir | Magnesium citrate | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
833,
24,
603
]
],
[
[
833,
64,
57
],
[
57,
24,
603
]
],
[
[
833,
24,
1616
],
[
1616,
24,
603
]
],
[
[
833,
63,
688
],
[
688,
24,... | [
[
[
"Lopinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Lopinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Lopinavir may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Lopinavir may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and Histr... |
DB00762 | DB11978 | 613 | 124 | [
"DDInter973",
"DDInter822"
] | Irinotecan | Glasdegib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
613,
24,
124
]
],
[
[
613,
24,
466
],
[
466,
62,
124
]
],
[
[
613,
24,
327
],
[
327,
24,
124
]
],
[
[
613,
63,
79
],
[
79,
24,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Abametapir and Abame... |
DB01083 | DB08903 | 1,142 | 996 | [
"DDInter1348",
"DDInter170"
] | Orlistat | Bedaquiline | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
1142,
24,
996
]
],
[
[
1142,
6,
8374
],
[
8374,
45,
996
]
],
[
[
1142,
21,
29402
],
[
29402,
60,
996
]
],
[
[
1142,
24,
1613
],
[
1613... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Orlistat",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Orlistat (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Orlistat (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Bedaquiline (Compound)
Orlistat may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00005 | DB00087 | 1,057 | 599 | [
"DDInter687",
"DDInter41"
] | Etanercept | Alemtuzumab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Moderate | 1 | [
[
[
1057,
24,
599
]
],
[
[
1057,
24,
597
],
[
597,
63,
599
]
],
[
[
1057,
25,
281
],
[
281,
63,
599
]
],
[
[
1057,
24,
367
],
[
367,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab
Etanercept may lead to a major life threatening interaction when taken with Levamisole and Levamisole... |
DB00563 | DB01099 | 663 | 1,272 | [
"DDInter1174",
"DDInter744"
] | Methotrexate | Flucytosine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
663,
24,
1272
]
],
[
[
663,
7,
18134
],
[
18134,
46,
1272
]
],
[
[
663,
18,
19732
],
[
19732,
57,
1272
]
],
[
[
663,
7,
7335
],
[
7335... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Methotrexate",
"{u} (Compound) upregulates {v} (Gene)",
"POLD4"
],
[
"POLD4",
"{u} (Gene) is upregulated by {... | Methotrexate (Compound) upregulates POLD4 (Gene) and POLD4 (Gene) is upregulated by Flucytosine (Compound)
Methotrexate (Compound) downregulates GRWD1 (Gene) and GRWD1 (Gene) is downregulated by Flucytosine (Compound)
Methotrexate (Compound) upregulates LIG1 (Gene) and LIG1 (Gene) is downregulated by Flucytosine (Compo... |
DB00857 | DB12015 | 1,387 | 1,033 | [
"DDInter1768",
"DDInter53"
] | Terbinafine | Alpelisib | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1387,
24,
1033
]
],
[
[
1387,
25,
1510
],
[
1510,
24,
1033
]
],
[
[
1387,
24,
772
],
[
772,
24,
1033
]
],
[
[
1387,
63,
322
],
[
322,
... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Terbinafine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
],
[
"Terifl... | Terbinafine may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Carvedilol may... |
DB01255 | DB11837 | 633 | 1,297 | [
"DDInter1078",
"DDInter1351"
] | Lisdexamfetamine | Osilodrostat | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
633,
24,
1297
]
],
[
[
633,
62,
112
],
[
112,
23,
1297
]
],
[
[
633,
64,
222
],
[
222,
23,
1297
]
],
[
[
633,
63,
401
],
[
401,
... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Lisdexamfetamine may lead to a major life threatening interaction when taken with Sibutramine and Sibu... |
DB00800 | DB00959 | 572 | 1,486 | [
"DDInter720",
"DDInter1191"
] | Fenoldopam | Methylprednisolone | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
572,
24,
1486
]
],
[
[
572,
63,
175
],
[
175,
40,
1486
]
],
[
[
572,
63,
167
],
[
167,
1,
1486
]
],
[
[
572,
24,
1220
],
[
1220,
... | [
[
[
"Fenoldopam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Fenoldopam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Fenoldopam may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Fenoldopam may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB00294 | DB12332 | 1,336 | 1,619 | [
"DDInter701",
"DDInter1626"
] | Etonogestrel | Rucaparib | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1336,
24,
1619
]
],
[
[
1336,
24,
259
],
[
259,
24,
1619
]
],
[
[
1336,
63,
58
],
[
58,
24,
1619
]
],
[
[
1336,
24,
1501
],
[
1501,
... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[... | Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alef... |
DB00603 | DB12130 | 303 | 1,017 | [
"DDInter1137",
"DDInter1094"
] | Medroxyprogesterone acetate | Lorlatinib | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
303,
24,
1017
]
],
[
[
303,
64,
1101
],
[
1101,
23,
1017
]
],
[
[
303,
63,
590
],
[
590,
24,
1017
]
],
[
[
303,
23,
14
],
[
14,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarote... | Medroxyprogesterone acetate may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Acet... |
DB00624 | DB00860 | 1,561 | 891 | [
"DDInter1775",
"DDInter1513"
] | Testosterone | Prednisolone | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1561,
24,
891
]
],
[
[
1561,
1,
11347
],
[
11347,
40,
891
]
],
[
[
1561,
40,
989
],
[
989,
1,
891
]
],
[
[
1561,
40,
11388
],
[
11388,... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Testosterone",
"{u} (Compound) resembles {v} (Compound)",
"Hydrocortamate"
],
[
"Hydrocortamate",
"{u} (Comp... | Testosterone (Compound) resembles Hydrocortamate (Compound) and Hydrocortamate (Compound) resembles Prednisolone (Compound)
Testosterone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Prednisolone (Compound)
Testosterone (Compound) resembles Cortisone acetate (Compound) and Cortisone... |
DB00812 | DB06626 | 998 | 263 | [
"DDInter1451",
"DDInter147"
] | Phenylbutazone | Axitinib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Moderate | 1 | [
[
[
998,
24,
263
]
],
[
[
998,
63,
702
],
[
702,
24,
263
]
],
[
[
998,
24,
392
],
[
392,
24,
263
]
],
[
[
998,
24,
1593
],
[
1593,
6... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axitinib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anagrelide"
],
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide and Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Axitinib
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and L... |
DB00661 | DB09054 | 122 | 384 | [
"DDInter1928",
"DDInter905"
] | Verapamil | Idelalisib | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
122,
24,
384
]
],
[
[
122,
23,
222
],
[
222,
23,
384
]
],
[
[
122,
24,
1618
],
[
1618,
24,
384
]
],
[
[
122,
62,
1512
],
[
1512,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Verapamil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
... | Verapamil may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozant... |
DB06335 | DB13179 | 761 | 68 | [
"DDInter1646",
"DDInter1882"
] | Saxagliptin | Troleandomycin | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
761,
24,
68
]
],
[
[
761,
64,
1101
],
[
1101,
23,
68
]
],
[
[
761,
63,
222
],
[
222,
23,
68
]
],
[
[
761,
63,
251
],
[
251,
24,
... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Saxagliptin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexa... | Saxagliptin may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may ... |
DB00398 | DB08880 | 79 | 1,510 | [
"DDInter1702",
"DDInter1771"
] | Sorafenib | Teriflunomide | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
79,
25,
1510
]
],
[
[
79,
24,
129
],
[
129,
63,
1510
]
],
[
[
79,
24,
1088
],
[
1088,
24,
1510
]
],
[
[
79,
63,
1061
],
[
1061,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
"Enzalut... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Rifaximin and Ri... |
DB00420 | DB00445 | 508 | 322 | [
"DDInter1532",
"DDInter655"
] | Promazine | Epirubicin | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
508,
24,
322
]
],
[
[
508,
7,
8606
],
[
8606,
46,
322
]
],
[
[
508,
7,
7669
],
[
7669,
57,
322
]
],
[
[
508,
18,
1918
],
[
1918,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Promazine",
"{u} (Compound) upregulates {v} (Gene)",
"ALDOC"
],
[
"ALDOC",
"{u} (Gene) is upregulated by {v} (Com... | Promazine (Compound) upregulates ALDOC (Gene) and ALDOC (Gene) is upregulated by Epirubicin (Compound)
Promazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is downregulated by Epirubicin (Compound)
Promazine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Epirubicin (Compound)
Promazi... |
DB00647 | DB01181 | 675 | 1,532 | [
"DDInter528",
"DDInter906"
] | Dextropropoxyphene | Ifosfamide | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
675,
24,
1532
]
],
[
[
675,
6,
3486
],
[
3486,
45,
1532
]
],
[
[
675,
7,
5415
],
[
5415,
46,
1532
]
],
[
[
675,
21,
28900
],
[
28900,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by ... | Dextropropoxyphene (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ifosfamide (Compound)
Dextropropoxyphene (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Ifosfamide (Compound)
Dextropropoxyphene (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is ca... |
DB00607 | DB08901 | 1,249 | 1,468 | [
"DDInter1256",
"DDInter1492"
] | Nafcillin | Ponatinib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1249,
24,
1468
]
],
[
[
1249,
24,
478
],
[
478,
24,
1468
]
],
[
[
1249,
6,
8374
],
[
8374,
45,
1468
]
],
[
[
1249,
7,
3422
],
[
3422,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Nafcillin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound)
Nafcillin (Compound) upr... |
DB00347 | DB00434 | 917 | 13 | [
"DDInter1871",
"DDInter459"
] | Trimethadione | Cyproheptadine | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Moderate | 1 | [
[
[
917,
24,
13
]
],
[
[
917,
21,
29455
],
[
29455,
60,
13
]
],
[
[
917,
24,
717
],
[
717,
63,
13
]
],
[
[
917,
24,
128
],
[
128,
24... | [
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]
],
[
[
"Trimethadione",
"{u} (Compound) causes {v} (Side Effect)",
"Agranulocytosis"
],
[
"Agranulocytosis",
"{u}... | Trimethadione (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Cyproheptadine (Compound)
Trimethadione may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide and Trimethobenzamide may cause a moderate interaction that could exacerb... |
DB00675 | DB09078 | 888 | 1,228 | [
"DDInter1744",
"DDInter1036"
] | Tamoxifen | Lenvatinib | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
888,
24,
1228
]
],
[
[
888,
23,
112
],
[
112,
23,
1228
]
],
[
[
888,
24,
463
],
[
463,
23,
1228
]
],
[
[
888,
63,
1100
],
[
1100,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Tamoxifen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifamp... |
DB00812 | DB12364 | 998 | 1,421 | [
"DDInter1451",
"DDInter200"
] | Phenylbutazone | Betrixaban | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
998,
25,
1421
]
],
[
[
998,
24,
1513
],
[
1513,
24,
1421
]
],
[
[
998,
40,
362
],
[
362,
24,
1421
]
],
[
[
998,
63,
305
],
[
305,
... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apremilast"
],
[
"Ap... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Apremilast and Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Phenylbutazone (Compound) resembles Phenytoin (Compound) and Phenytoin may cause a moderate interaction that... |
DB00024 | DB00414 | 818 | 590 | [
"DDInter1800",
"DDInter16"
] | Thyrotropin alfa | Acetohexamide | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
818,
24,
590
]
],
[
[
818,
24,
549
],
[
549,
63,
590
]
],
[
[
818,
24,
176
],
[
176,
24,
590
]
],
[
[
818,
24,
549
],
[
549,
62,... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozi... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00261 | DB06603 | 702 | 39 | [
"DDInter93",
"DDInter1387"
] | Anagrelide | Panobinostat | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
702,
25,
39
]
],
[
[
702,
23,
1247
],
[
1247,
23,
39
]
],
[
[
702,
24,
479
],
[
479,
23,
39
]
],
[
[
702,
24,
282
],
[
282,
63,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Anagrelide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Anagrelide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Donepezil a... |
DB06176 | DB11601 | 1,342 | 1,270 | [
"DDInter1616",
"DDInter1889"
] | Romidepsin | Tuberculin purified protein derivative | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1342,
24,
1270
]
],
[
[
1342,
63,
1531
],
[
1531,
24,
1270
]
],
[
[
1342,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
1342,
24,
1250
],
[
12... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Romidepsin may lead to a major life threatening interaction when taken with Cladri... |
DB01050 | DB14730 | 848 | 1,412 | [
"DDInter900",
"DDInter264"
] | Ibuprofen | Calaspargase pegol | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
848,
24,
1412
]
],
[
[
848,
25,
792
],
[
792,
24,
1412
]
],
[
[
848,
63,
1347
],
[
1347,
24,
1412
]
],
[
[
848,
64,
553
],
[
553,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
],
[
"Riv... | Ibuprofen may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel ... |
DB00092 | DB01023 | 58 | 409 | [
"DDInter40",
"DDInter716"
] | Alefacept | Felodipine | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
58,
24,
409
]
],
[
[
58,
24,
376
],
[
376,
40,
409
]
],
[
[
58,
24,
1428
],
[
1428,
1,
409
]
],
[
[
58,
24,
1031
],
[
1031,
23,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Felodipine (Compound)
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Felodipine (Compound)
Al... |
DB00176 | DB01216 | 529 | 284 | [
"DDInter770",
"DDInter736"
] | Fluvoxamine | Finasteride | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting a... | Moderate | 1 | [
[
[
529,
24,
284
]
],
[
[
529,
6,
6799
],
[
6799,
45,
284
]
],
[
[
529,
21,
29247
],
[
29247,
60,
284
]
],
[
[
529,
24,
629
],
[
629,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Finasteride"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7"
],
[
"CYP3A7",
"{u} (Gene) is bound by {v} (Compound... | Fluvoxamine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Finasteride (Compound)
Fluvoxamine (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Finasteride (Compound)
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus ... |
DB00877 | DB12035 | 629 | 943 | [
"DDInter1678",
"DDInter1641"
] | Sirolimus | Sarecycline | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
629,
24,
943
]
],
[
[
629,
63,
1181
],
[
1181,
24,
943
]
],
[
[
629,
24,
1456
],
[
1456,
24,
943
]
],
[
[
629,
24,
1619
],
[
1619,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terfenadine"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine and Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venet... |
DB00862 | DB11110 | 1,005 | 603 | [
"DDInter1918",
"DDInter1115"
] | Vardenafil | Magnesium citrate | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1005,
24,
603
]
],
[
[
1005,
25,
57
],
[
57,
24,
603
]
],
[
[
1005,
24,
1616
],
[
1616,
24,
603
]
],
[
[
1005,
24,
484
],
[
484,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Vardenafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Vardenafil may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and His... |
DB01069 | DB01364 | 401 | 22 | [
"DDInter1533",
"DDInter650"
] | Promethazine | Ephedrine | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
401,
24,
22
]
],
[
[
401,
63,
80
],
[
80,
24,
22
]
],
[
[
401,
24,
1529
],
[
1529,
63,
22
]
],
[
[
401,
6,
5214
],
[
5214,
45,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine an... |
DB06414 | DB09065 | 655 | 760 | [
"DDInter703",
"DDInter424"
] | Etravirine | Cobicistat | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
655,
24,
760
]
],
[
[
655,
62,
1101
],
[
1101,
23,
760
]
],
[
[
655,
63,
1195
],
[
1195,
24,
760
]
],
[
[
655,
24,
868
],
[
868,
... | [
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Etravirine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Etravirine may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib m... |
DB00619 | DB06595 | 1,419 | 1,491 | [
"DDInter909",
"DDInter1214"
] | Imatinib | Midostaurin | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1419,
24,
1491
]
],
[
[
1419,
25,
1135
],
[
1135,
62,
1491
]
],
[
[
1419,
24,
761
],
[
761,
24,
1491
]
],
[
[
1419,
63,
289
],
[
289,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Imatinib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a mod... |
DB00683 | DB08820 | 1,382 | 1,478 | [
"DDInter1212",
"DDInter997"
] | Midazolam | Ivacaftor | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1382,
24,
1478
]
],
[
[
1382,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1382,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
1382,
24,
985
],
[
98... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Midazolam",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Midazolam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Midazolam (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and Osimertini... |
DB00196 | DB01403 | 600 | 9 | [
"DDInter743",
"DDInter1175"
] | Fluconazole | Methotrimeprazine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
600,
24,
9
]
],
[
[
600,
24,
1178
],
[
1178,
40,
9
]
],
[
[
600,
24,
1164
],
[
1164,
1,
9
]
],
[
[
600,
25,
684
],
[
684,
40,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles... |
DB00445 | DB11627 | 322 | 1,367 | [
"DDInter655",
"DDInter860"
] | Epirubicin | Hepatitis B Vaccine (Recombinant) | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
322,
24,
1367
]
],
[
[
322,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
322,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
322,
24,
1480
],
[
1480,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alde... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Epirubicin may lead to a major life threatening interaction when taken with Cladribine ... |
DB08904 | DB09054 | 375 | 384 | [
"DDInter342",
"DDInter905"
] | Certolizumab pegol | Idelalisib | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
375,
25,
384
]
],
[
[
375,
25,
725
],
[
725,
63,
384
]
],
[
[
375,
64,
328
],
[
328,
24,
384
]
],
[
[
375,
63,
289
],
[
289,
24,... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
],
[
"Satrali... | Certolizumab pegol may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Certolizumab pegol may lead to a major life threatening interaction when taken with Mercaptopurine and Mercaptopuri... |
DB09009 | DB14740 | 285 | 771 | [
"DDInter123",
"DDInter881"
] | Articaine | Hyaluronidase | Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
285,
23,
771
]
],
[
[
285,
40,
490
],
[
490,
23,
771
]
],
[
[
285,
6,
8927
],
[
8927,
45,
490
],
[
490,
23,
771
]
],
[
[
285,
40... | [
[
[
"Articaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Articaine",
"{u} (Compound) resembles {v} (Compound)",
"Prilocaine"
],
[
"Prilocaine",
"{u} may cause a minor in... | Articaine (Compound) resembles Prilocaine (Compound) and Prilocaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Articaine (Compound) binds SCN3A (Gene) and SCN3A (Gene) is bound by Prilocaine (Compound) and Prilocaine may cause a minor interaction that can limit clinical ... |
DB00328 | DB09135 | 831 | 1,211 | [
"DDInter921",
"DDInter967"
] | Indomethacin | Ioxilan | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
831,
25,
1211
]
],
[
[
831,
24,
712
],
[
712,
25,
1211
]
],
[
[
831,
25,
629
],
[
629,
25,
1211
]
],
[
[
831,
40,
1263
],
[
1263,
... | [
[
[
"Indomethacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[
"Olsalazin... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may lead to a major life threatening interaction when taken with Ioxilan
Indomethacin may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may lead to a major life t... |
DB09065 | DB09118 | 760 | 1,580 | [
"DDInter424",
"DDInter1711"
] | Cobicistat | Stiripentol | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
760,
24,
1580
]
],
[
[
760,
24,
466
],
[
466,
62,
1580
]
],
[
[
760,
64,
1409
],
[
1409,
24,
1580
]
],
[
[
760,
25,
283
],
[
283,
... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Stiripentol
Cobicistat may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a... |
DB01083 | DB08864 | 1,142 | 786 | [
"DDInter1348",
"DDInter1595"
] | Orlistat | Rilpivirine | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
1142,
24,
786
]
],
[
[
1142,
24,
655
],
[
655,
1,
786
]
],
[
[
1142,
6,
8374
],
[
8374,
45,
786
]
],
[
[
1142,
21,
28734
],
[
28734,
... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
],
[
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etravirine (Compound) resembles Rilpivirine (Compound)
Orlistat (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Orlistat (Compound) causes Immune system disorder (Side Effect) and ... |
DB08873 | DB11760 | 74 | 119 | [
"DDInter221",
"DDInter1742"
] | Boceprevir | Talazoparib | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
74,
24,
119
]
],
[
[
74,
25,
985
],
[
985,
24,
119
]
],
[
[
74,
64,
1478
],
[
1478,
24,
119
]
],
[
[
74,
25,
1406
],
[
1406,
63,... | [
[
[
"Boceprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
],
[
"Osimerti... | Boceprevir may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Boceprevir may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a moderate int... |
DB01254 | DB06441 | 1,213 | 936 | [
"DDInter484",
"DDInter283"
] | Dasatinib | Cangrelor | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Major | 2 | [
[
[
1213,
25,
936
]
],
[
[
1213,
23,
944
],
[
944,
62,
936
]
],
[
[
1213,
64,
97
],
[
97,
24,
936
]
],
[
[
1213,
63,
383
],
[
383,
2... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cangrelor"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Cangrelor
Dasatinib may lead to a major life threatening interaction when taken with Oxaprozin and Oxaprozin may cause a moderate ... |
DB00631 | DB00857 | 372 | 1,387 | [
"DDInter405",
"DDInter1768"
] | Clofarabine | Terbinafine | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
372,
24,
1387
]
],
[
[
372,
7,
8318
],
[
8318,
46,
1387
]
],
[
[
372,
18,
7212
],
[
7212,
57,
1387
]
],
[
[
372,
7,
17905
],
[
17905,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Clofarabine",
"{u} (Compound) upregulates {v} (Gene)",
"DMTF1"
],
[
"DMTF1",
"{u} (Gene) is upregulated by {v}... | Clofarabine (Compound) upregulates DMTF1 (Gene) and DMTF1 (Gene) is upregulated by Terbinafine (Compound)
Clofarabine (Compound) downregulates HMG20B (Gene) and HMG20B (Gene) is downregulated by Terbinafine (Compound)
Clofarabine (Compound) upregulates TIGAR (Gene) and TIGAR (Gene) is downregulated by Terbinafine (Comp... |
DB00288 | DB06655 | 1,103 | 5 | [
"DDInter63",
"DDInter1077"
] | Amcinonide | Liraglutide | Amcinonide is a corticosteroid. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Minor | 0 | [
[
[
1103,
23,
5
]
],
[
[
1103,
40,
870
],
[
870,
24,
5
]
],
[
[
1103,
62,
245
],
[
245,
24,
5
]
],
[
[
1103,
23,
1411
],
[
1411,
24,... | [
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Liraglutide"
]
],
[
[
"Amcinonide",
"{u} (Compound) resembles {v} (Compound)",
"Fludrocortisone"
],
[
"Fludrocortisone",
"{u} may cause ... | Amcinonide (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Amcinonide may cause a minor interaction that can limit clinical effects when taken with Glimepiride and Glimepiride may cause a moderate interaction... |
DB00285 | DB01362 | 1,100 | 497 | [
"DDInter1927",
"DDInter960"
] | Venlafaxine | Iohexol | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1100,
25,
497
]
],
[
[
1100,
21,
28681
],
[
28681,
60,
497
]
],
[
[
1100,
24,
1574
],
[
1574,
63,
497
]
],
[
[
1100,
24,
530
],
[
530,... | [
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Venlafaxine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effect) is caused... | Venlafaxine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Urea and Urea may cause a moderate interaction that could exacerbate diseases when taken with Iohexo... |
DB00078 | DB00749 | 1,172 | 59 | [
"DDInter898",
"DDInter699"
] | Ibritumomab tiuxetan | Etodolac | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Major | 2 | [
[
[
1172,
25,
59
]
],
[
[
1172,
64,
25
],
[
25,
24,
59
]
],
[
[
1172,
25,
1018
],
[
1018,
24,
59
]
],
[
[
1172,
24,
1039
],
[
1039,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etodolac"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anistreplase"
],
[
"Anist... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Ticlopidine and Ticlopidine m... |
DB01142 | DB06707 | 1,264 | 584 | [
"DDInter593",
"DDInter1060"
] | Doxepin | Levonordefrin | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. | Major | 2 | [
[
[
1264,
25,
584
]
],
[
[
1264,
23,
1191
],
[
1191,
40,
584
]
],
[
[
1264,
64,
817
],
[
817,
40,
584
]
],
[
[
1264,
63,
1148
],
[
1148,
... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levonordefrin"
]
],
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levodopa"
],
[
"Levodopa",
... | Doxepin may cause a minor interaction that can limit clinical effects when taken with Levodopa and Levodopa (Compound) resembles Levonordefrin (Compound)
Doxepin may lead to a major life threatening interaction when taken with Dopamine and Dopamine (Compound) resembles Levonordefrin (Compound)
Doxepin may cause a moder... |
DB04837 | DB12161 | 649 | 730 | [
"DDInter407",
"DDInter512"
] | Clofedanol | Deutetrabenazine | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
649,
24,
730
]
],
[
[
649,
63,
100
],
[
100,
24,
730
]
],
[
[
649,
74,
662
],
[
662,
24,
730
]
],
[
[
649,
1,
888
],
[
888,
24,
... | [
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Clofedanol (Compound) resembles Carbinoxamine (Compound) and Clofedanol may cause a moderate int... |
DB04868 | DB08820 | 478 | 1,478 | [
"DDInter1293",
"DDInter997"
] | Nilotinib | Ivacaftor | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
478,
24,
1478
]
],
[
[
478,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
478,
21,
30495
],
[
30495,
60,
1478
]
],
[
[
478,
23,
907
],
[
907,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Nilotinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Nilotinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Nilotinib (Compound) causes Pleuritic pain (Side Effect) and Pleuritic pain (Side Effect) is caused by Ivacaftor (Compound)
Nilotinib may cause a minor interaction that can limit clinical effects when taken with Doravirine and D... |
DB00615 | DB00916 | 690 | 112 | [
"DDInter1589",
"DDInter1202"
] | Rifabutin | Metronidazole | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
690,
24,
112
]
],
[
[
690,
24,
458
],
[
458,
40,
112
]
],
[
[
690,
6,
8374
],
[
8374,
45,
112
]
],
[
[
690,
21,
28757
],
[
28757,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
],
[
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) resembles Metronidazole (Compound)
Rifabutin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound)
Rifabutin (Compound) causes Dyspepsia (Side Effect) and Dyspep... |
DB00176 | DB01129 | 529 | 379 | [
"DDInter770",
"DDInter1559"
] | Fluvoxamine | Rabeprazole | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Moderate | 1 | [
[
[
529,
24,
379
]
],
[
[
529,
24,
1215
],
[
1215,
40,
379
]
],
[
[
529,
24,
660
],
[
660,
1,
379
]
],
[
[
529,
6,
8374
],
[
8374,
4... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole... |
DB00457 | DB01050 | 1,205 | 848 | [
"DDInter1511",
"DDInter900"
] | Prazosin | Ibuprofen | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1205,
24,
848
]
],
[
[
1205,
24,
1053
],
[
1053,
1,
848
]
],
[
[
1205,
6,
4973
],
[
4973,
45,
848
]
],
[
[
1205,
21,
29404
],
[
29404,... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
],
[
... | Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Prazosin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ibuprofen (Compound)
Prazosin (Compound) causes Cataract (Side Effect) and Cataract (Side E... |
DB05239 | DB08827 | 866 | 990 | [
"DDInter425",
"DDInter1085"
] | Cobimetinib | Lomitapide | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
866,
25,
990
]
],
[
[
866,
64,
1080
],
[
1080,
1,
990
]
],
[
[
866,
24,
1362
],
[
1362,
63,
990
]
],
[
[
866,
63,
322
],
[
322,
... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",
"{u}... | Cobimetinib may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate disea... |
DB00783 | DB08881 | 1,438 | 868 | [
"DDInter679",
"DDInter1925"
] | Estradiol | Vemurafenib | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
1438,
24,
868
]
],
[
[
1438,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1438,
7,
7933
],
[
7933,
46,
868
]
],
[
[
1438,
18,
2884
],
[
2884,
... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Estradiol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Estradiol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Estradiol (Compound) upregulates DDX42 (Gene) and DDX42 (Gene) is upregulated by Vemurafenib (Compound)
Estradiol (Compound) downregulates ECH1 (Gene) and ECH1 (Gene) is upregulated by Vemurafenib (Compound)
Estradiol (Compoun... |
DB00675 | DB09082 | 888 | 659 | [
"DDInter1744",
"DDInter1934"
] | Tamoxifen | Vilanterol | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
888,
24,
659
]
],
[
[
888,
24,
1220
],
[
1220,
23,
659
]
],
[
[
888,
63,
1570
],
[
1570,
24,
659
]
],
[
[
888,
24,
927
],
[
927,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Az... |
DB00867 | DB11718 | 1,052 | 927 | [
"DDInter1606",
"DDInter640"
] | Ritodrine | Encorafenib | Adrenergic beta-agonist used to control premature labor. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1052,
24,
927
]
],
[
[
1052,
24,
659
],
[
659,
24,
927
]
],
[
[
1052,
63,
1010
],
[
1010,
24,
927
]
],
[
[
1052,
24,
484
],
[
484,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloqu... |
DB00552 | DB01004 | 1,238 | 563 | [
"DDInter1425",
"DDInter806"
] | Pentostatin | Ganciclovir | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Moderate | 1 | [
[
[
1238,
24,
563
]
],
[
[
1238,
24,
248
],
[
248,
40,
563
]
],
[
[
1238,
21,
29233
],
[
29233,
60,
563
]
],
[
[
1238,
25,
770
],
[
770,
... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
]
],
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Pentostatin (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Ganciclovir (Compound)
Pentostati... |
DB01254 | DB06603 | 1,213 | 39 | [
"DDInter484",
"DDInter1387"
] | Dasatinib | Panobinostat | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1213,
25,
39
]
],
[
[
1213,
62,
1247
],
[
1247,
23,
39
]
],
[
[
1213,
24,
282
],
[
282,
63,
39
]
],
[
[
1213,
63,
1257
],
[
1257,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfam... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Nepafenac and... |
DB06616 | DB09082 | 594 | 659 | [
"DDInter224",
"DDInter1934"
] | Bosutinib | Vilanterol | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
594,
24,
659
]
],
[
[
594,
64,
1220
],
[
1220,
23,
659
]
],
[
[
594,
63,
1570
],
[
1570,
24,
659
]
],
[
[
594,
24,
927
],
[
927,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexametha... | Bosutinib may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may ... |
DB01110 | DB01229 | 86 | 973 | [
"DDInter1209",
"DDInter1377"
] | Miconazole | Paclitaxel | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
86,
24,
973
]
],
[
[
86,
24,
310
],
[
310,
63,
973
]
],
[
[
86,
6,
8374
],
[
8374,
45,
973
]
],
[
[
86,
18,
2183
],
[
2183,
46,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Miconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Miconazole (Comp... |
DB08826 | DB09036 | 1,292 | 812 | [
"DDInter489",
"DDInter1668"
] | Deferiprone | Siltuximab | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Major | 2 | [
[
[
1292,
25,
812
]
],
[
[
1292,
24,
1193
],
[
1193,
62,
812
]
],
[
[
1292,
64,
147
],
[
147,
24,
812
]
],
[
[
1292,
25,
975
],
[
975,
... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Siltuximab"
]
],
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
],
[
"Zinc... | Deferiprone may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Siltuximab
Deferiprone may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine ... |
DB00563 | DB12015 | 663 | 1,033 | [
"DDInter1174",
"DDInter53"
] | Methotrexate | Alpelisib | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
663,
24,
1033
]
],
[
[
663,
24,
738
],
[
738,
24,
1033
]
],
[
[
663,
25,
1510
],
[
1510,
24,
1033
]
],
[
[
663,
63,
322
],
[
322,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Methotrexate may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may... |
DB09038 | DB11796 | 1,450 | 1,612 | [
"DDInter636",
"DDInter786"
] | Empagliflozin | Fostemsavir | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
1450,
24,
1612
]
],
[
[
1450,
24,
98
],
[
98,
23,
1612
]
],
[
[
1450,
24,
1476
],
[
1476,
62,
1612
]
],
[
[
1450,
63,
1220
],
[
1220,
... | [
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
... | Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Briga... |
DB00352 | DB01098 | 482 | 14 | [
"DDInter1814",
"DDInter1622"
] | Tioguanine | Rosuvastatin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
482,
24,
14
]
],
[
[
482,
24,
671
],
[
671,
24,
14
]
],
[
[
482,
6,
9320
],
[
9320,
45,
14
]
],
[
[
482,
21,
28826
],
[
28826,
6... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Tioguanine (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Rosuvastatin (Compound)
Tioguanine (Co... |
DB00227 | DB11569 | 1,463 | 1,093 | [
"DDInter1098",
"DDInter1003"
] | Lovastatin | Ixekizumab | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
1463,
24,
1093
]
],
[
[
1463,
24,
134
],
[
134,
24,
1093
]
],
[
[
1463,
63,
58
],
[
58,
24,
1093
]
],
[
[
1463,
35,
467
],
[
467,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefa... |
DB00747 | DB00981 | 1,442 | 1,528 | [
"DDInter1647",
"DDInter1462"
] | Scopolamine | Physostigmine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
1442,
24,
1528
]
],
[
[
1442,
21,
28658
],
[
28658,
60,
1528
]
],
[
[
1442,
24,
1592
],
[
1592,
63,
1528
]
],
[
[
1442,
63,
508
],
[
5... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Scopolamine",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is c... | Scopolamine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Physostigmine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Nebivolol and Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Physos... |
DB00323 | DB09241 | 1,062 | 1,629 | [
"DDInter1829",
"DDInter1186"
] | Tolcapone | Methylene blue | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1062,
25,
1629
]
],
[
[
1062,
24,
1148
],
[
1148,
24,
1629
]
],
[
[
1062,
1,
1533
],
[
1533,
25,
1629
]
],
[
[
1062,
24,
407
],
[
407,... | [
[
[
"Tolcapone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
"Isopre... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Tolcapone (Compound) resembles Entacapone (Compound) and Entacapone may lead to a major life threatening ... |
DB01001 | DB01227 | 688 | 1,301 | [
"DDInter1632",
"DDInter1043"
] | Salbutamol | Levacetylmethadol | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Moderate | 1 | [
[
[
688,
24,
1301
]
],
[
[
688,
63,
494
],
[
494,
1,
1301
]
],
[
[
688,
6,
8374
],
[
8374,
45,
1301
]
],
[
[
688,
62,
112
],
[
112,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levacetylmethadol (Compound)
Salbutamol may cause a minor interaction that ca... |
DB01224 | DB04868 | 623 | 478 | [
"DDInter1553",
"DDInter1293"
] | Quetiapine | Nilotinib | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
623,
25,
478
]
],
[
[
623,
6,
4973
],
[
4973,
45,
478
]
],
[
[
623,
7,
1720
],
[
1720,
46,
478
]
],
[
[
623,
18,
5587
],
[
5587,
... | [
[
[
"Quetiapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Quetiapine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Nilotinib"... | Quetiapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Quetiapine (Compound) upregulates RELB (Gene) and RELB (Gene) is upregulated by Nilotinib (Compound)
Quetiapine (Compound) downregulates SCAND1 (Gene) and SCAND1 (Gene) is downregulated by Nilotinib (Compound)
Quetiapine (Compoun... |
DB00023 | DB08932 | 305 | 1,398 | [
"DDInter127",
"DDInter1111"
] | Asparaginase Escherichia coli | Macitentan | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Moderate | 1 | [
[
[
305,
24,
1398
]
],
[
[
305,
24,
1478
],
[
1478,
24,
1398
]
],
[
[
305,
25,
1101
],
[
1101,
24,
1398
]
],
[
[
305,
24,
1613
],
[
1613,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macitentan"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Macitentan
Asparaginase Escherichia coli may lead to a major life threatening interaction when taken with ... |
DB00397 | DB00451 | 1,466 | 542 | [
"DDInter1458",
"DDInter1064"
] | Phenylpropanolamine | Levothyroxine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
1466,
24,
542
]
],
[
[
1466,
63,
1152
],
[
1152,
1,
542
]
],
[
[
1466,
7,
4634
],
[
4634,
46,
542
]
],
[
[
1466,
18,
2183
],
[
2183,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothy... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Levothyroxine (Compound)
Phenylpropanolamine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Levothyroxine (Compound)
Phenylpropanolamine (Compoun... |
DB00750 | DB01612 | 490 | 1,637 | [
"DDInter1518",
"DDInter92"
] | Prilocaine | Amyl Nitrite | A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165) | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Major | 2 | [
[
[
490,
25,
1637
]
],
[
[
490,
64,
10
],
[
10,
24,
1637
]
],
[
[
490,
25,
1455
],
[
1455,
64,
1637
]
],
[
[
490,
64,
10
],
[
10,
24... | [
[
[
"Prilocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Prilocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dapsone"
],
[
"Dapsone",
"{u} may c... | Prilocaine may lead to a major life threatening interaction when taken with Dapsone and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Prilocaine may lead to a major life threatening interaction when taken with Nitrous acid and Nitrous acid may lead to a major life ... |
DB01285 | DB09473 | 708 | 884 | [
"DDInter445",
"DDInter918"
] | Corticotropin | Indium In-111 oxyquinoline | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
708,
24,
884
]
],
[
[
708,
63,
1648
],
[
1648,
24,
884
]
],
[
[
708,
63,
1680
],
[
1680,
62,
1572
],
[
1572,
24,
884
]
],
[
[
708,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldes... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Corticotropin may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB06605 | DB09293 | 1,409 | 116 | [
"DDInter108",
"DDInter954"
] | Apixaban | Iodide I-131 | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1409,
24,
116
]
],
[
[
1409,
63,
1249
],
[
1249,
24,
116
]
],
[
[
1409,
24,
1004
],
[
1004,
63,
116
]
],
[
[
1409,
25,
365
],
[
365,
... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phe... |
DB00059 | DB01259 | 1,560 | 392 | [
"DDInter1404",
"DDInter1024"
] | Pegaspargase | Lapatinib | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1560,
24,
392
]
],
[
[
1560,
24,
1247
],
[
1247,
23,
392
]
],
[
[
1560,
24,
918
],
[
918,
24,
392
]
],
[
[
1560,
24,
263
],
[
263,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Lapatinib
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Bicaluta... |
DB00710 | DB09322 | 1,199 | 1,114 | [
"DDInter897",
"DDInter1966"
] | Ibandronate | Zinc sulfate | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Moderate | 1 | [
[
[
1199,
24,
1114
]
],
[
[
1199,
25,
629
],
[
629,
23,
1114
]
],
[
[
1199,
24,
1596
],
[
1596,
23,
1114
]
],
[
[
1199,
24,
428
],
[
428,
... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Ibandronate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
],
[
"Sirolim... | Ibandronate may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a minor inte... |
DB00675 | DB13074 | 888 | 877 | [
"DDInter1744",
"DDInter1110"
] | Tamoxifen | Macimorelin | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
888,
25,
877
]
],
[
[
888,
23,
112
],
[
112,
23,
877
]
],
[
[
888,
24,
1320
],
[
1320,
24,
877
]
],
[
[
888,
63,
288
],
[
288,
2... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Tamoxifen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagoli... |
DB00277 | DB00443 | 1,031 | 251 | [
"DDInter1791",
"DDInter195"
] | Theophylline | Betamethasone | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
1031,
24,
251
]
],
[
[
1031,
24,
617
],
[
617,
40,
251
]
],
[
[
1031,
24,
870
],
[
870,
1,
251
]
],
[
[
1031,
5,
11649
],
[
11649,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Betamethasone (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betam... |
DB00086 | DB09068 | 1,167 | 1,427 | [
"DDInter1712",
"DDInter1948"
] | Streptokinase | Vortioxetine | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1167,
24,
1427
]
],
[
[
1167,
25,
256
],
[
256,
24,
1427
]
],
[
[
1167,
24,
477
],
[
477,
24,
1427
]
],
[
[
1167,
64,
366
],
[
366,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Streptokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Pra... | Streptokinase may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may ... |
DB00046 | DB01175 | 1,179 | 318 | [
"DDInter940",
"DDInter672"
] | Insulin lispro | Escitalopram | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
1179,
24,
318
]
],
[
[
1179,
24,
1230
],
[
1230,
1,
318
]
],
[
[
1179,
24,
168
],
[
168,
23,
318
]
],
[
[
1179,
24,
999
],
[
999,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
]... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction tha... |
DB01232 | DB01278 | 1,327 | 1,021 | [
"DDInter1640",
"DDInter1506"
] | Saquinavir | Pramlintide | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1327,
24,
1021
]
],
[
[
1327,
63,
1142
],
[
1142,
24,
1021
]
],
[
[
1327,
25,
1019
],
[
1019,
63,
1021
]
],
[
[
1327,
64,
485
],
[
485... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
],
[
... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Saquinavir may lead to a major life threatening interaction when taken with Deflazacort and Deflazacort may cause a... |
DB00465 | DB06605 | 886 | 1,409 | [
"DDInter1010",
"DDInter108"
] | Ketorolac | Apixaban | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
886,
25,
1409
]
],
[
[
886,
21,
29666
],
[
29666,
60,
1409
]
],
[
[
886,
63,
1560
],
[
1560,
24,
1409
]
],
[
[
886,
24,
1220
],
[
1220... | [
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Ketorolac",
"{u} (Compound) causes {v} (Side Effect)",
"Melaena"
],
[
"Melaena",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Ketorolac (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Apixaban
Ke... |
DB01076 | DB08880 | 700 | 1,510 | [
"DDInter133",
"DDInter1771"
] | Atorvastatin | Teriflunomide | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
700,
25,
1510
]
],
[
[
700,
24,
129
],
[
129,
63,
1510
]
],
[
[
700,
62,
303
],
[
303,
24,
1510
]
],
[
[
700,
63,
10
],
[
10,
24... | [
[
[
"Atorvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
"E... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Atorvastatin may cause a minor interaction that can limit clinical effects when taken with Medroxyproge... |
DB00731 | DB00850 | 1,144 | 1,630 | [
"DDInter1269",
"DDInter1432"
] | Nateglinide | Perphenazine | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
1144,
24,
1630
]
],
[
[
1144,
63,
508
],
[
508,
40,
1630
]
],
[
[
1144,
24,
673
],
[
673,
40,
1630
]
],
[
[
1144,
6,
12523
],
[
12523,... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Perphenazine (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole (Compound) resembles Perphenazine (Co... |
DB00014 | DB00346 | 521 | 472 | [
"DDInter839",
"DDInter44"
] | Goserelin | Alfuzosin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Moderate | 1 | [
[
[
521,
24,
472
]
],
[
[
521,
21,
28784
],
[
28784,
60,
472
]
],
[
[
521,
23,
112
],
[
112,
62,
472
]
],
[
[
521,
24,
1151
],
[
1151,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfuzosin"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Thrombocytopenia"
],
[
"Thrombocytopenia",
"{u} (Side Effe... | Goserelin (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Alfuzosin (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken... |
DB00350 | DB01088 | 1,214 | 714 | [
"DDInter1226",
"DDInter908"
] | Minoxidil | Iloprost | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1214,
24,
714
]
],
[
[
1214,
23,
402
],
[
402,
23,
714
]
],
[
[
1214,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1214,
24,
1450
],
[
1450,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Minoxidil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tadalafil"
],
[
"Ta... | Minoxidil may cause a minor interaction that can limit clinical effects when taken with Tadalafil and Tadalafil may cause a minor interaction that can limit clinical effects when taken with Iloprost
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may... |
DB00514 | DB00776 | 506 | 1,335 | [
"DDInter527",
"DDInter1360"
] | Dextromethorphan | Oxcarbazepine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
506,
24,
1335
]
],
[
[
506,
24,
820
],
[
820,
63,
1335
]
],
[
[
506,
24,
1236
],
[
1236,
1,
1335
]
],
[
[
506,
63,
902
],
[
902,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Carb... |
DB00065 | DB08826 | 581 | 1,292 | [
"DDInter923",
"DDInter489"
] | Infliximab | Deferiprone | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
581,
25,
1292
]
],
[
[
581,
24,
45
],
[
45,
24,
1292
]
],
[
[
581,
23,
1193
],
[
1193,
63,
1292
]
],
[
[
581,
25,
482
],
[
482,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
],
[
"Didanosin... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Infliximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zin... |
DB08860 | DB11901 | 788 | 913 | [
"DDInter1479",
"DDInter107"
] | Pitavastatin | Apalutamide | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
788,
24,
913
]
],
[
[
788,
63,
112
],
[
112,
23,
913
]
],
[
[
788,
40,
671
],
[
671,
24,
913
]
],
[
[
788,
63,
458
],
[
458,
24,... | [
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Pitavastatin (Compound) resembles Fluvastatin (Compound) and Fluvastatin may cause a moderate interaction... |
DB00341 | DB00418 | 1,242 | 536 | [
"DDInter343",
"DDInter1650"
] | Cetirizine | Secobarbital | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Moderate | 1 | [
[
[
1242,
24,
536
]
],
[
[
1242,
63,
1023
],
[
1023,
1,
536
]
],
[
[
1242,
24,
697
],
[
697,
1,
536
]
],
[
[
1242,
24,
682
],
[
682,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Secobarbital (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Secobarb... |
DB00414 | DB00491 | 590 | 127 | [
"DDInter16",
"DDInter1217"
] | Acetohexamide | Miglitol | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
590,
24,
127
]
],
[
[
590,
62,
1103
],
[
1103,
23,
127
]
],
[
[
590,
24,
1194
],
[
1194,
62,
127
]
],
[
[
590,
24,
984
],
[
984,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Acetohexamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
... | Acetohexamide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Miglitol
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Raniti... |
DB00580 | DB00704 | 311 | 267 | [
"DDInter1910",
"DDInter1263"
] | Valdecoxib | Naltrexone | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
311,
24,
267
]
],
[
[
311,
63,
522
],
[
522,
24,
267
]
],
[
[
311,
24,
850
],
[
850,
63,
267
]
],
[
[
311,
24,
1512
],
[
1512,
2... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin... |
DB00679 | DB01114 | 684 | 272 | [
"DDInter1796",
"DDInter362"
] | Thioridazine | Chlorpheniramine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
684,
24,
272
]
],
[
[
684,
1,
1237
],
[
1237,
63,
272
]
],
[
[
684,
24,
849
],
[
849,
63,
272
]
],
[
[
684,
63,
128
],
[
128,
24... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Thioridazine",
"{u} (Compound) resembles {v} (Compound)",
"Clomipramine"
],
[
"Clomipramine",
"{u} may c... | Thioridazine (Compound) resembles Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interact... |
DB00108 | DB11834 | 1,066 | 1,303 | [
"DDInter1268",
"DDInter849"
] | Natalizumab | Guselkumab | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Major | 2 | [
[
[
1066,
25,
1303
]
],
[
[
1066,
23,
1193
],
[
1193,
23,
1303
]
],
[
[
1066,
24,
949
],
[
949,
24,
1303
]
],
[
[
1066,
25,
713
],
[
713,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Guselkumab"
]
],
[
[
"Natalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc g... | Natalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Guselkumab
Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tet... |
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