drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00188 | DB08886 | 168 | 637 | [
"DDInter222",
"DDInter126"
] | Bortezomib | Asparaginase Erwinia chrysanthemi | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
168,
24,
637
]
],
[
[
168,
63,
491
],
[
491,
24,
637
]
],
[
[
168,
24,
5
],
[
5,
24,
637
]
],
[
[
168,
24,
1385
],
[
1385,
63,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegi... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Bortezomib may cause a moderate interaction that could exacerbate d... |
DB00675 | DB04855 | 888 | 540 | [
"DDInter1744",
"DDInter602"
] | Tamoxifen | Dronedarone | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
888,
25,
540
]
],
[
[
888,
64,
347
],
[
347,
40,
540
]
],
[
[
888,
25,
33
],
[
33,
40,
540
]
],
[
[
888,
6,
8374
],
[
8374,
45,
... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} (Com... | Tamoxifen may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Dronedarone (Compound)
Tamoxifen may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Tamoxifen (Compound) binds CYP3A... |
DB00783 | DB01285 | 1,438 | 708 | [
"DDInter680",
"DDInter445"
] | Estradiol (topical) | Corticotropin | 17beta-estradiol is the 17beta-isomer of estradiol. It has a role as an estrogen, a human metabolite, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a Daphnia magna metabolite, a mouse metabolite and a geroprotector. It is a 17beta-hydroxy steroid and an estradiol. | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1438,
24,
708
]
],
[
[
1438,
23,
771
],
[
771,
62,
708
]
],
[
[
1438,
63,
245
],
[
245,
24,
708
]
],
[
[
1438,
24,
170
],
[
170,
... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Estradiol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
],
[
... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Estr... |
DB00035 | DB00991 | 1,314 | 97 | [
"DDInter507",
"DDInter1358"
] | Desmopressin | Oxaprozin | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
1314,
24,
97
]
],
[
[
1314,
24,
1274
],
[
1274,
24,
97
]
],
[
[
1314,
24,
576
],
[
576,
1,
97
]
],
[
[
1314,
24,
1236
],
[
1236,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Methadone and ... |
DB00459 | DB08827 | 640 | 990 | [
"DDInter21",
"DDInter1085"
] | Acitretin | Lomitapide | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
640,
25,
990
]
],
[
[
640,
21,
29441
],
[
29441,
60,
990
]
],
[
[
640,
63,
322
],
[
322,
24,
990
]
],
[
[
640,
63,
305
],
[
305,
... | [
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Acitretin",
"{u} (Compound) causes {v} (Side Effect)",
"White blood cell count increased"
],
[
"White blood cell count increased",
... | Acitretin (Compound) causes White blood cell count increased (Side Effect) and White blood cell count increased (Side Effect) is caused by Lomitapide (Compound)
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could... |
DB00637 | DB11110 | 1,557 | 603 | [
"DDInter128",
"DDInter1115"
] | Astemizole | Magnesium citrate | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1557,
24,
603
]
],
[
[
1557,
25,
57
],
[
57,
24,
603
]
],
[
[
1557,
63,
789
],
[
789,
24,
603
]
],
[
[
1557,
24,
1616
],
[
1616,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Astemizole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Astemizole may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Fos... |
DB01249 | DB15066 | 258 | 445 | [
"DDInter958",
"DDInter821"
] | Iodixanol | Givosiran | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Major | 2 | [
[
[
258,
25,
445
]
],
[
[
258,
64,
589
],
[
589,
24,
445
]
],
[
[
258,
25,
712
],
[
712,
24,
445
]
],
[
[
258,
64,
629
],
[
629,
25,... | [
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Givosiran"
]
],
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
],
[
"Cisplatin",
"{u} may ca... | Iodixanol may lead to a major life threatening interaction when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Iodixanol may lead to a major life threatening interaction when taken with Olsalazine and Olsalazine may cause a moderate interacti... |
DB00213 | DB11071 | 837 | 1,004 | [
"DDInter1388",
"DDInter1449"
] | Pantoprazole | Phenyl salicylate | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Minor | 0 | [
[
[
837,
23,
1004
]
],
[
[
837,
1,
1215
],
[
1215,
23,
1004
]
],
[
[
837,
24,
416
],
[
416,
24,
1004
]
],
[
[
837,
23,
256
],
[
256,
... | [
[
[
"Pantoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Pantoprazole",
"{u} (Compound) resembles {v} (Compound)",
"Lansoprazole"
],
[
"Lansoprazole",
"{u} may ca... | Pantoprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin may cause a moderate interaction... |
DB08865 | DB12887 | 1,593 | 1,598 | [
"DDInter448",
"DDInter1750"
] | Crizotinib | Tazemetostat | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Major | 2 | [
[
[
1593,
25,
1598
]
],
[
[
1593,
64,
594
],
[
594,
24,
1598
]
],
[
[
1593,
25,
985
],
[
985,
24,
1598
]
],
[
[
1593,
63,
310
],
[
310,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tazemetostat"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
],
[
"Bosutinib",
"{u} m... | Crizotinib may lead to a major life threatening interaction when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Crizotinib may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a moderate in... |
DB01045 | DB09073 | 463 | 951 | [
"DDInter1590",
"DDInter1379"
] | Rifampicin | Palbociclib | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
463,
25,
951
]
],
[
[
463,
25,
1476
],
[
1476,
63,
951
]
],
[
[
463,
24,
710
],
[
710,
63,
951
]
],
[
[
463,
64,
467
],
[
467,
2... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib",
"{u} ... | Rifampicin may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Binimetinib may cau... |
DB01136 | DB01229 | 772 | 973 | [
"DDInter305",
"DDInter1377"
] | Carvedilol | Paclitaxel | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
772,
24,
973
]
],
[
[
772,
6,
8374
],
[
8374,
45,
973
]
],
[
[
772,
18,
2183
],
[
2183,
46,
973
]
],
[
[
772,
21,
29267
],
[
29267,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Carvedilol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Carvedilol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Carvedilol (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is upregulated by Paclitaxel (Compound)
Carvedilol (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Si... |
DB01612 | DB04844 | 1,637 | 843 | [
"DDInter92",
"DDInter1778"
] | Amyl Nitrite | Tetrabenazine | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
1637,
24,
843
]
],
[
[
1637,
63,
1376
],
[
1376,
24,
843
]
],
[
[
1637,
24,
849
],
[
849,
63,
843
]
],
[
[
1637,
63,
1053
],
[
1053,
... | [
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine
Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Mepy... |
DB00661 | DB11093 | 122 | 636 | [
"DDInter1928",
"DDInter273"
] | Verapamil | Calcium citrate | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
122,
24,
636
]
],
[
[
122,
5,
11590
],
[
11590,
44,
819
],
[
819,
24,
636
]
],
[
[
122,
6,
12523
],
[
12523,
45,
819
],
[
819,
24,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Verapamil",
"{u} (Compound) treats {v} (Disease)",
"hypertension"
],
[
"hypertension",
"{u} (Disease) is tre... | Verapamil (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Verapamil (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Acebutolol (Compound) an... |
DB00382 | DB04843 | 62 | 1,511 | [
"DDInter1734",
"DDInter1149"
] | Tacrine | Mepenzolate | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
62,
24,
1511
]
],
[
[
62,
24,
1192
],
[
1192,
24,
1511
]
],
[
[
62,
63,
352
],
[
352,
24,
1511
]
],
[
[
62,
24,
849
],
[
849,
63... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trosp... |
DB04865 | DB14444 | 4 | 151 | [
"DDInter1335",
"DDInter924"
] | Omacetaxine mepesuccinate | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
4,
24,
151
]
],
[
[
4,
63,
66
],
[
66,
24,
151
]
],
[
[
4,
24,
1619
],
[
1619,
24,
151
]
],
[
[
4,
25,
397
],
[
397,
24,
1... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a mod... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Omacetaxine mepesuccin... |
DB11691 | DB11730 | 1,499 | 351 | [
"DDInter1258",
"DDInter1588"
] | Naldemedine | Ribociclib | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1499,
24,
351
]
],
[
[
1499,
24,
283
],
[
283,
62,
351
]
],
[
[
1499,
63,
1249
],
[
1249,
24,
351
]
],
[
[
1499,
24,
1654
],
[
1654,
... | [
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcill... |
DB01064 | DB01105 | 1,148 | 222 | [
"DDInter987",
"DDInter1665"
] | Isoprenaline | Sibutramine | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1148,
24,
222
]
],
[
[
1148,
21,
28698
],
[
28698,
60,
222
]
],
[
[
1148,
64,
839
],
[
839,
23,
222
]
],
[
[
1148,
63,
600
],
[
600,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Isoprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is c... | Isoprenaline (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Isoprenaline may lead to a major life threatening interaction when taken with Grepafloxacin and Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Iso... |
DB00014 | DB01268 | 521 | 1,151 | [
"DDInter839",
"DDInter1731"
] | Goserelin | Sunitinib | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
521,
24,
1151
]
],
[
[
521,
21,
29269
],
[
29269,
60,
1151
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],
[
[
521,
23,
1247
],
[
1247,
23,
1151
]
],
[
[
521,
24,
1148
],
[
1148... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Menopausal symptoms"
],
[
"Menopausal symptoms",
"{u} (Sid... | Goserelin (Compound) causes Menopausal symptoms (Side Effect) and Menopausal symptoms (Side Effect) is caused by Sunitinib (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effect... |
DB00104 | DB00622 | 966 | 1,081 | [
"DDInter1323",
"DDInter1287"
] | Octreotide | Nicardipine | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Moderate | 1 | [
[
[
966,
24,
1081
]
],
[
[
966,
24,
409
],
[
409,
1,
1081
]
],
[
[
966,
21,
28676
],
[
28676,
60,
1081
]
],
[
[
966,
24,
159
],
[
159,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicardipine"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
],
[
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine (Compound) resembles Nicardipine (Compound)
Octreotide (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Nicardipine (Compound)
Octreotide may cause a moderate intera... |
DB00333 | DB00431 | 576 | 1,503 | [
"DDInter1166",
"DDInter1072"
] | Methadone | Lindane | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Moderate | 1 | [
[
[
576,
24,
1503
]
],
[
[
576,
21,
28703
],
[
28703,
60,
1503
]
],
[
[
576,
1,
939
],
[
939,
63,
1503
]
],
[
[
576,
24,
104
],
[
104,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lindane"
]
],
[
[
"Methadone",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused by {... | Methadone (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Lindane (Compound)
Methadone (Compound) resembles Benzphetamine (Compound) and Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with Lindane
Methadone may cause a moderate interaction that ... |
DB06717 | DB11837 | 875 | 1,297 | [
"DDInter778",
"DDInter1351"
] | Fosaprepitant | Osilodrostat | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
875,
24,
1297
]
],
[
[
875,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
875,
23,
466
],
[
466,
62,
1297
]
],
[
[
875,
62,
222
],
[
222,
... | [
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Fosaprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Nal... | Fosaprepitant may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Fosaprepitant may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may ... |
DB00816 | DB12825 | 1,674 | 1,375 | [
"DDInter1346",
"DDInter1032"
] | Orciprenaline | Lefamulin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
1674,
25,
1375
]
],
[
[
1674,
24,
659
],
[
659,
24,
1375
]
],
[
[
1674,
62,
870
],
[
870,
24,
1375
]
],
[
[
1674,
63,
1324
],
[
1324,
... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[
"Vilan... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone an... |
DB00835 | DB00843 | 100 | 479 | [
"DDInter245",
"DDInter583"
] | Brompheniramine | Donepezil | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
100,
24,
479
]
],
[
[
100,
24,
843
],
[
843,
1,
479
]
],
[
[
100,
6,
12523
],
[
12523,
45,
479
]
],
[
[
100,
18,
20113
],
[
20113,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Brompheniramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Brompheniramine (Compound) downregulates IER3 (Gene)... |
DB00095 | DB14762 | 66 | 994 | [
"DDInter623",
"DDInter1602"
] | Efalizumab | Risankizumab | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Moderate | 1 | [
[
[
66,
24,
994
]
],
[
[
66,
23,
1114
],
[
1114,
23,
994
]
],
[
[
66,
24,
4
],
[
4,
24,
994
]
],
[
[
66,
63,
58
],
[
58,
24,
9... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risankizumab"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Risankizumab
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuc... |
DB00652 | DB01069 | 234 | 401 | [
"DDInter1421",
"DDInter1533"
] | Pentazocine | Promethazine | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
234,
24,
401
]
],
[
[
234,
24,
1264
],
[
1264,
63,
401
]
],
[
[
234,
24,
104
],
[
104,
24,
401
]
],
[
[
234,
21,
28709
],
[
28709,
... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdi... |
DB00726 | DB11901 | 1,164 | 913 | [
"DDInter1876",
"DDInter107"
] | Trimipramine | Apalutamide | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1164,
24,
913
]
],
[
[
1164,
23,
112
],
[
112,
23,
913
]
],
[
[
1164,
63,
600
],
[
600,
24,
913
]
],
[
[
1164,
1,
1237
],
[
1237,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Trimipramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Trimipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB00398 | DB00916 | 79 | 112 | [
"DDInter1702",
"DDInter1202"
] | Sorafenib | Metronidazole | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
79,
23,
112
]
],
[
[
79,
6,
3486
],
[
3486,
45,
112
]
],
[
[
79,
7,
16981
],
[
16981,
46,
112
]
],
[
[
79,
21,
28692
],
[
28692,
... | [
[
[
"Sorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Sorafenib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Sorafenib (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Sorafenib (Compound) upregulates ZNF586 (Gene) and ZNF586 (Gene) is upregulated by Metronidazole (Compound)
Sorafenib (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Metronidazo... |
DB00215 | DB01110 | 1,230 | 86 | [
"DDInter388",
"DDInter1209"
] | Citalopram | Miconazole | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Minor | 0 | [
[
[
1230,
23,
86
]
],
[
[
1230,
6,
6365
],
[
6365,
45,
86
]
],
[
[
1230,
21,
29122
],
[
29122,
60,
86
]
],
[
[
1230,
1,
318
],
[
318,
... | [
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Miconazole"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)",
... | Citalopram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Miconazole (Compound)
Citalopram (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Miconazole (Compound)
Citalopram (Compound) resembles Escitalopram (Compound) and Es
Citalopram may lead to a ... |
DB00321 | DB00377 | 21 | 1,494 | [
"DDInter78",
"DDInter1382"
] | Amitriptyline | Palonosetron | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Major | 2 | [
[
[
21,
25,
1494
]
],
[
[
21,
6,
12523
],
[
12523,
45,
1494
]
],
[
[
21,
21,
28709
],
[
28709,
60,
1494
]
],
[
[
21,
23,
112
],
[
112,
... | [
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palonosetron"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Amitriptyline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Palonosetron (Compound)
Amitriptyline (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Palonosetron (Compound)
Amitriptyline may cause a minor interaction that can limit clinical effects when t... |
DB00330 | DB00445 | 238 | 322 | [
"DDInter689",
"DDInter655"
] | Ethambutol | Epirubicin | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
238,
24,
322
]
],
[
[
238,
21,
28701
],
[
28701,
60,
322
]
],
[
[
238,
24,
112
],
[
112,
62,
322
]
],
[
[
238,
24,
134
],
[
134,
... | [
[
[
"Ethambutol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Ethambutol",
"{u} (Compound) causes {v} (Side Effect)",
"Discomfort"
],
[
"Discomfort",
"{u} (Side Effect) is ca... | Ethambutol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Epirubicin (Compound)
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with E... |
DB00188 | DB01265 | 168 | 1,477 | [
"DDInter222",
"DDInter1757"
] | Bortezomib | Telbivudine | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
168,
24,
1477
]
],
[
[
168,
24,
139
],
[
139,
1,
1477
]
],
[
[
168,
21,
28745
],
[
28745,
60,
1477
]
],
[
[
168,
24,
112
],
[
112,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) resembles Telbivudine (Compound)
Bortezomib (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Telbivudine (Compound)
Bortezomib may cau... |
DB00408 | DB00782 | 1,408 | 1,123 | [
"DDInter1099",
"DDInter1535"
] | Loxapine | Propantheline | An antipsychotic agent used in schizophrenia. [PubChem] | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
1408,
24,
1123
]
],
[
[
1408,
6,
7992
],
[
7992,
45,
1123
]
],
[
[
1408,
21,
28898
],
[
28898,
60,
1123
]
],
[
[
1408,
35,
537
],
[
53... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Loxapine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)",
... | Loxapine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Loxapine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propantheline (Compound)
Loxapine (Compound) resembles Cyclizine (Compound) and Loxapine may cause a moderate interaction that co... |
DB00682 | DB09098 | 126 | 98 | [
"DDInter1951",
"DDInter1700"
] | Warfarin | Somatrem | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
126,
24,
98
]
],
[
[
126,
62,
168
],
[
168,
23,
98
]
],
[
[
126,
23,
271
],
[
271,
23,
98
]
],
[
[
126,
23,
671
],
[
671,
24,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
"Bor... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Warfarin may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cau... |
DB00222 | DB14006 | 245 | 972 | [
"DDInter825",
"DDInter370"
] | Glimepiride | Choline salicylate | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
245,
24,
972
]
],
[
[
245,
23,
660
],
[
660,
23,
972
]
],
[
[
245,
24,
1573
],
[
1573,
24,
972
]
],
[
[
245,
63,
176
],
[
176,
2... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Glimepiride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
]... | Glimepiride may cause a minor interaction that can limit clinical effects when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Prednisone ... |
DB00544 | DB00685 | 970 | 1,299 | [
"DDInter757",
"DDInter1887"
] | Fluorouracil | Trovafloxacin | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Minor | 0 | [
[
[
970,
23,
1299
]
],
[
[
970,
23,
872
],
[
872,
40,
1299
]
],
[
[
970,
62,
1467
],
[
1467,
40,
1299
]
],
[
[
970,
21,
29028
],
[
29028,
... | [
[
[
"Fluorouracil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Fluorouracil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
],
... | Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Trovafloxacin (Comp... |
DB00197 | DB01001 | 1,324 | 688 | [
"DDInter1881",
"DDInter1632"
] | Troglitazone | Salbutamol | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1324,
24,
688
]
],
[
[
1324,
24,
874
],
[
874,
24,
688
]
],
[
[
1324,
24,
1148
],
[
1148,
63,
688
]
],
[
[
1324,
24,
1220
],
[
1220,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline an... |
DB01211 | DB12301 | 609 | 907 | [
"DDInter393",
"DDInter585"
] | Clarithromycin | Doravirine | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Minor | 0 | [
[
[
609,
23,
907
]
],
[
[
609,
25,
1478
],
[
1478,
23,
907
]
],
[
[
609,
25,
159
],
[
159,
62,
907
]
],
[
[
609,
62,
600
],
[
600,
2... | [
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Ivaca... | Clarithromycin may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Clarithromycin may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a min... |
DB04868 | DB15982 | 478 | 1,339 | [
"DDInter1293",
"DDInter193"
] | Nilotinib | Berotralstat | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
478,
24,
1339
]
],
[
[
478,
64,
1101
],
[
1101,
23,
1339
]
],
[
[
478,
63,
222
],
[
222,
23,
1339
]
],
[
[
478,
24,
283
],
[
283,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Nilotinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause ... |
DB00222 | DB06723 | 245 | 115 | [
"DDInter825",
"DDInter58"
] | Glimepiride | Aluminum hydroxide | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
245,
24,
115
]
],
[
[
245,
21,
28829
],
[
28829,
60,
115
]
],
[
[
245,
24,
1058
],
[
1058,
23,
115
]
],
[
[
245,
64,
1176
],
[
1176,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Hyponatraemia"
],
[
"Hyponatraemia",
"{u} (Si... | Glimepiride (Compound) causes Hyponatraemia (Side Effect) and Hyponatraemia (Side Effect) is caused by Aluminum hydroxide (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Moexipril and Moexipril may cause a minor interaction that can limit clinical effects when take... |
DB00443 | DB00622 | 251 | 1,081 | [
"DDInter195",
"DDInter1287"
] | Betamethasone | Nicardipine | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Moderate | 1 | [
[
[
251,
24,
1081
]
],
[
[
251,
24,
409
],
[
409,
1,
1081
]
],
[
[
251,
63,
1428
],
[
1428,
1,
1081
]
],
[
[
251,
6,
8374
],
[
8374,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicardipine"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine (Compound) resembles Nicardipine (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nicardipine (Co... |
DB00065 | DB01234 | 581 | 1,220 | [
"DDInter923",
"DDInter513"
] | Infliximab | Dexamethasone | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Major | 2 | [
[
[
581,
25,
1220
]
],
[
[
581,
25,
870
],
[
870,
1,
1220
]
],
[
[
581,
25,
175
],
[
175,
40,
1220
]
],
[
[
581,
24,
1382
],
[
1382,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludrocortisone"
],
[
"Fludrocortisone",... | Infliximab may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Infliximab may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamethasone (Compound)
Inflixim... |
DB00418 | DB11186 | 536 | 1,609 | [
"DDInter1650",
"DDInter1427"
] | Secobarbital | Pentoxyverine | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
536,
24,
1609
]
],
[
[
536,
24,
104
],
[
104,
24,
1609
]
],
[
[
536,
63,
999
],
[
999,
24,
1609
]
],
[
[
536,
1,
682
],
[
682,
2... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Thiethylpe... |
DB00615 | DB11581 | 690 | 1,456 | [
"DDInter1589",
"DDInter1926"
] | Rifabutin | Venetoclax | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
690,
25,
1456
]
],
[
[
690,
24,
1135
],
[
1135,
23,
1456
]
],
[
[
690,
25,
1476
],
[
1476,
63,
1456
]
],
[
[
690,
23,
86
],
[
86,
... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Rifabutin may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a mode... |
DB11110 | DB11642 | 603 | 938 | [
"DDInter1115",
"DDInter1480"
] | Magnesium citrate | Pitolisant | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
603,
24,
938
]
],
[
[
603,
63,
600
],
[
600,
24,
938
]
],
[
[
603,
24,
927
],
[
927,
63,
938
]
],
[
[
603,
63,
1154
],
[
1154,
2... | [
[
[
"Magnesium citrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Magnesium citrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
... | Magnesium citrate may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Magnesium citrate may cause a moderate interaction that could exacerbate diseases when taken with Encor... |
DB00031 | DB00991 | 20 | 97 | [
"DDInter1764",
"DDInter1358"
] | Tenecteplase | Oxaprozin | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
20,
24,
97
]
],
[
[
20,
24,
1274
],
[
1274,
24,
97
]
],
[
[
20,
24,
998
],
[
998,
1,
97
]
],
[
[
20,
25,
936
],
[
936,
63,
... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
... | Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone... |
DB00201 | DB00363 | 1,684 | 695 | [
"DDInter263",
"DDInter419"
] | Caffeine | Clozapine | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Minor | 0 | [
[
[
1684,
23,
695
]
],
[
[
1684,
6,
12523
],
[
12523,
45,
695
]
],
[
[
1684,
23,
1387
],
[
1387,
63,
695
]
],
[
[
1684,
24,
868
],
[
868,
... | [
[
[
"Caffeine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clozapine"
]
],
[
[
"Caffeine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Caffeine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Clozapine (Compound)
Caffeine may cause a minor interaction that can limit clinical effects when taken with Terbinafine and Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine
Caffeine may cause a mod... |
DB00377 | DB08881 | 1,494 | 868 | [
"DDInter1382",
"DDInter1925"
] | Palonosetron | Vemurafenib | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1494,
25,
868
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1494,
21,
28847
],
[
28847,
60,
868
]
],
[
[
1494,
24,
479
],
[
479,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ve... | Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Palonosetron (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Vemurafenib (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Donep... |
DB00046 | DB00206 | 1,179 | 1,245 | [
"DDInter940",
"DDInter1582"
] | Insulin lispro | Reserpine | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Moderate | 1 | [
[
[
1179,
24,
1245
]
],
[
[
1179,
24,
1340
],
[
1340,
1,
1245
]
],
[
[
1179,
24,
22
],
[
22,
63,
1245
]
],
[
[
1179,
24,
73
],
[
73,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Reserpine"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deserpidine"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Deserpidine and Deserpidine (Compound) resembles Reserpine (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine may cause a moderate interaction tha... |
DB00308 | DB00738 | 347 | 485 | [
"DDInter901",
"DDInter1420"
] | Ibutilide | Pentamidine | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Major | 2 | [
[
[
347,
25,
485
]
],
[
[
347,
21,
28722
],
[
28722,
60,
485
]
],
[
[
347,
23,
112
],
[
112,
62,
485
]
],
[
[
347,
25,
971
],
[
971,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentamidine"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (Compound)",... | Ibutilide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Pentamidine (Compound)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pentamidine
... |
DB01261 | DB08912 | 170 | 1,040 | [
"DDInter1679",
"DDInter462"
] | Sitagliptin | Dabrafenib | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
170,
24,
1040
]
],
[
[
170,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
170,
18,
6824
],
[
6824,
46,
1040
]
],
[
[
170,
18,
4112
],
[
4112,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Sitagliptin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Sitagliptin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Sitagliptin (Compound) downregulates CHAC1 (Gene) and CHAC1 (Gene) is upregulated by Dabrafenib (Compound)
Sitagliptin (Compound) downregulates AURKB (Gene) and AURKB (Gene) is downregulated by Dabrafenib (Compound)
Sitagliptin... |
DB00762 | DB11791 | 613 | 785 | [
"DDInter973",
"DDInter287"
] | Irinotecan | Capmatinib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
613,
24,
785
]
],
[
[
613,
63,
1324
],
[
1324,
24,
785
]
],
[
[
613,
24,
868
],
[
868,
24,
785
]
],
[
[
613,
24,
1320
],
[
1320,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and V... |
DB00241 | DB09330 | 288 | 985 | [
"DDInter257",
"DDInter1352"
] | Butalbital | Osimertinib | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
288,
24,
985
]
],
[
[
288,
62,
168
],
[
168,
23,
985
]
],
[
[
288,
24,
112
],
[
112,
23,
985
]
],
[
[
288,
23,
608
],
[
608,
23,... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Butalbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Butalbital may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metron... |
DB01166 | DB08881 | 477 | 868 | [
"DDInter379",
"DDInter1925"
] | Cilostazol | Vemurafenib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
477,
25,
868
]
],
[
[
477,
6,
8374
],
[
8374,
45,
868
]
],
[
[
477,
7,
3422
],
[
3422,
46,
868
]
],
[
[
477,
18,
9384
],
[
9384,
... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Cilostazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemura... | Cilostazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Cilostazol (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Vemurafenib (Compound)
Cilostazol (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Vemurafenib (Compound)
Cilostazol (C... |
DB01177 | DB13139 | 77 | 1,032 | [
"DDInter904",
"DDInter1063"
] | Idarubicin | Levosalbutamol | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
77,
24,
1032
]
],
[
[
77,
25,
1618
],
[
1618,
24,
1032
]
],
[
[
77,
24,
124
],
[
124,
24,
1032
]
],
[
[
77,
25,
982
],
[
982,
63... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabo... | Idarubicin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may ... |
DB06663 | DB08870 | 1,154 | 850 | [
"DDInter1398",
"DDInter228"
] | Pasireotide | Brentuximab vedotin | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1154,
24,
850
]
],
[
[
1154,
64,
1570
],
[
1570,
24,
850
]
],
[
[
1154,
63,
267
],
[
267,
24,
850
]
],
[
[
1154,
24,
1412
],
[
1412,
... | [
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azithromycin"
],
[
... | Pasireotide may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltre... |
DB00046 | DB00254 | 1,179 | 964 | [
"DDInter940",
"DDInter598"
] | Insulin lispro | Doxycycline | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Moderate | 1 | [
[
[
1179,
24,
964
]
],
[
[
1179,
24,
1572
],
[
1572,
40,
964
]
],
[
[
1179,
24,
1620
],
[
1620,
1,
964
]
],
[
[
1179,
24,
1399
],
[
1399,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Doxycycline (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles D... |
DB01233 | DB04908 | 1,311 | 1,671 | [
"DDInter1197",
"DDInter741"
] | Metoclopramide | Flibanserin | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
1311,
24,
1671
]
],
[
[
1311,
24,
741
],
[
741,
63,
1671
]
],
[
[
1311,
24,
830
],
[
830,
24,
1671
]
],
[
[
1311,
63,
1594
],
[
1594,
... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine... |
DB00595 | DB11248 | 1,545 | 1,193 | [
"DDInter1374",
"DDInter1965"
] | Oxytetracycline | Zinc gluconate | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
1545,
24,
1193
]
],
[
[
1545,
24,
1096
],
[
1096,
23,
1193
]
],
[
[
1545,
24,
260
],
[
260,
62,
1193
]
],
[
[
1545,
40,
1572
],
[
1572... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic ... | Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01064 | DB01285 | 1,148 | 708 | [
"DDInter987",
"DDInter445"
] | Isoprenaline | Corticotropin | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Minor | 0 | [
[
[
1148,
23,
708
]
],
[
[
1148,
63,
455
],
[
455,
23,
708
]
],
[
[
1148,
24,
659
],
[
659,
62,
708
]
],
[
[
1148,
74,
1674
],
[
1674,
... | [
[
[
"Isoprenaline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Corticotropin"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and V... |
DB01175 | DB04868 | 318 | 478 | [
"DDInter672",
"DDInter1293"
] | Escitalopram | Nilotinib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
318,
25,
478
]
],
[
[
318,
24,
1468
],
[
1468,
63,
478
]
],
[
[
318,
6,
8374
],
[
8374,
45,
478
]
],
[
[
318,
7,
8587
],
[
8587,
... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
"Ponatini... | Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Escitalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Escitalopram (Comp... |
DB00348 | DB01764 | 254 | 805 | [
"DDInter1300",
"DDInter469"
] | Nitisinone | Dalfopristin | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Moderate | 1 | [
[
[
254,
24,
805
]
],
[
[
254,
63,
1101
],
[
1101,
23,
805
]
],
[
[
254,
24,
283
],
[
283,
62,
805
]
],
[
[
254,
24,
384
],
[
384,
6... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfopristin"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB00188 | DB11989 | 168 | 1,434 | [
"DDInter222",
"DDInter183"
] | Bortezomib | Benznidazole | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
168,
24,
1434
]
],
[
[
168,
24,
788
],
[
788,
24,
1434
]
],
[
[
168,
25,
375
],
[
375,
24,
1434
]
],
[
[
168,
24,
148
],
[
148,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Bortezomib may lead to a major life threatening interaction when taken with Certolizumab pegol and Certoli... |
DB09035 | DB09054 | 410 | 384 | [
"DDInter1308",
"DDInter905"
] | Nivolumab | Idelalisib | Nivolumab is a fully human IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region with the mutation _S228P_ for additional stability and reduced variability. It was developed by Bristol Myers Squibb. N... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
410,
24,
384
]
],
[
[
410,
63,
891
],
[
891,
24,
384
]
],
[
[
410,
64,
1668
],
[
1668,
24,
384
]
],
[
[
410,
63,
1486
],
[
1486,
... | [
[
[
"Nivolumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Nivolumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
[
... | Nivolumab may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Nivolumab may lead to a major life threatening interaction when taken with Lenalidomide and Lenalidomide may ... |
DB01082 | DB09135 | 1,448 | 1,211 | [
"DDInter1713",
"DDInter967"
] | Streptomycin | Ioxilan | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
1448,
25,
1211
]
],
[
[
1448,
64,
1028
],
[
1028,
24,
1211
]
],
[
[
1448,
24,
242
],
[
242,
63,
1211
]
],
[
[
1448,
64,
894
],
[
894,
... | [
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Torasemide"
],
[
"Torasemide",
"{u} ... | Streptomycin may lead to a major life threatening interaction when taken with Torasemide and Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause... |
DB00446 | DB06589 | 597 | 1,250 | [
"DDInter351",
"DDInter1400"
] | Chloramphenicol | Pazopanib | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
597,
24,
1250
]
],
[
[
597,
6,
3486
],
[
3486,
45,
1250
]
],
[
[
597,
7,
2692
],
[
2692,
45,
1250
]
],
[
[
597,
18,
8397
],
[
8397,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Co... | Chloramphenicol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Pazopanib (Compound)
Chloramphenicol (Compound) upregulates KIT (Gene) and KIT (Gene) is bound by Pazopanib (Compound)
Chloramphenicol (Compound) downregulates PPP2R3C (Gene) and PPP2R3C (Gene) is upregulated by Pazopanib (Compound)
Chloramphe... |
DB00981 | DB06077 | 1,528 | 879 | [
"DDInter1463",
"DDInter1102"
] | Physostigmine (ophthalmic) | Lumateperone | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
1528,
24,
879
]
],
[
[
1528,
24,
1511
],
[
1511,
24,
879
]
],
[
[
1528,
63,
999
],
[
999,
24,
879
]
],
[
[
1528,
24,
849
],
[
849,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Lumateperon... |
DB00377 | DB08875 | 1,494 | 1,618 | [
"DDInter1382",
"DDInter262"
] | Palonosetron | Cabozantinib | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1494,
25,
1618
]
],
[
[
1494,
23,
112
],
[
112,
23,
1618
]
],
[
[
1494,
24,
1032
],
[
1032,
63,
1618
]
],
[
[
1494,
24,
480
],
[
480,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Palonosetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamo... |
DB00207 | DB08875 | 1,570 | 1,618 | [
"DDInter157",
"DDInter262"
] | Azithromycin | Cabozantinib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1570,
25,
1618
]
],
[
[
1570,
23,
1135
],
[
1135,
62,
1618
]
],
[
[
1570,
23,
112
],
[
112,
23,
1618
]
],
[
[
1570,
24,
384
],
[
384,
... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Azithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxeg... | Azithromycin may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metro... |
DB08880 | DB11714 | 1,510 | 1,316 | [
"DDInter1771",
"DDInter610"
] | Teriflunomide | Durvalumab | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Major | 2 | [
[
[
1510,
25,
1316
]
],
[
[
1510,
62,
1461
],
[
1461,
23,
1316
]
],
[
[
1510,
23,
1114
],
[
1114,
23,
1316
]
],
[
[
1510,
64,
167
],
[
167... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Durvalumab"
]
],
[
[
"Teriflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin... | Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Durvalumab
Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc s... |
DB00005 | DB00688 | 1,057 | 955 | [
"DDInter687",
"DDInter1251"
] | Etanercept | Mycophenolate mofetil | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Major | 2 | [
[
[
1057,
25,
955
]
],
[
[
1057,
25,
1096
],
[
1096,
40,
955
]
],
[
[
1057,
23,
1114
],
[
1114,
62,
955
]
],
[
[
1057,
24,
1031
],
[
1031,... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolate mofetil"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic acid"
],
[
"Mycophe... | Etanercept may lead to a major life threatening interaction when taken with Mycophenolic acid and Mycophenolic acid (Compound) resembles Mycophenolate mofetil (Compound)
Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction t... |
DB00023 | DB00660 | 305 | 1,470 | [
"DDInter127",
"DDInter1163"
] | Asparaginase Escherichia coli | Metaxalone | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous... | Moderate | 1 | [
[
[
305,
24,
1470
]
],
[
[
305,
24,
663
],
[
663,
24,
1470
]
],
[
[
305,
25,
770
],
[
770,
63,
1470
]
],
[
[
305,
24,
850
],
[
850,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metaxalone"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Metaxalone
Asparaginase Escherichia coli may lead to a major life threatening interaction when taken... |
DB00582 | DB00641 | 1,622 | 467 | [
"DDInter1946",
"DDInter1675"
] | Voriconazole | Simvastatin | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Major | 2 | [
[
[
1622,
25,
467
]
],
[
[
1622,
6,
8374
],
[
8374,
45,
467
]
],
[
[
1622,
21,
28810
],
[
28810,
60,
467
]
],
[
[
1622,
25,
126
],
[
126,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Simvastatin"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Si... | Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Simvastatin (Compound)
Voriconazole (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Simvastatin (Compound)
Voriconazole may lead to a major life threatening interaction when taken with Wa... |
DB00404 | DB11767 | 523 | 1,583 | [
"DDInter54",
"DDInter1643"
] | Alprazolam | Sarilumab | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
523,
24,
1583
]
],
[
[
523,
40,
1382
],
[
1382,
24,
1583
]
],
[
[
523,
24,
384
],
[
384,
24,
1583
]
],
[
[
523,
63,
58
],
[
58,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Alprazolam",
"{u} (Compound) resembles {v} (Compound)",
"Midazolam"
],
[
"Midazolam",
"{u} may cause a moderate i... | Alprazolam (Compound) resembles Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could ex... |
DB00652 | DB01233 | 234 | 1,311 | [
"DDInter1421",
"DDInter1197"
] | Pentazocine | Metoclopramide | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
234,
24,
1311
]
],
[
[
234,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
234,
24,
1383
],
[
1383,
63,
1311
]
],
[
[
234,
24,
662
],
[
662,
... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Pentazocine",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect)... | Pentazocine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate and Sodium sulfate may cause a moderate interaction that could exacerbate diseases when ta... |
DB00444 | DB00549 | 63 | 522 | [
"DDInter1765",
"DDInter1955"
] | Teniposide | Zafirlukast | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Moderate | 1 | [
[
[
63,
24,
522
]
],
[
[
63,
6,
8374
],
[
8374,
45,
522
]
],
[
[
63,
21,
28784
],
[
28784,
60,
522
]
],
[
[
63,
23,
307
],
[
307,
62... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
]
],
[
[
"Teniposide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Teniposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zafirlukast (Compound)
Teniposide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Zafirlukast (Compound)
Teniposide may cause a minor interaction that can limit clinical effects when taken with Modaf... |
DB00635 | DB01764 | 1,573 | 805 | [
"DDInter1515",
"DDInter469"
] | Prednisone | Dalfopristin | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Moderate | 1 | [
[
[
1573,
24,
805
]
],
[
[
1573,
6,
8374
],
[
8374,
45,
805
]
],
[
[
1573,
63,
1101
],
[
1101,
23,
805
]
],
[
[
1573,
24,
283
],
[
283,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfopristin"
]
],
[
[
"Prednisone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Prednisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dalfopristin (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Prednisone may c... |
DB00747 | DB01619 | 1,442 | 830 | [
"DDInter1647",
"DDInter1441"
] | Scopolamine | Phenindamine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1442,
24,
830
]
],
[
[
1442,
24,
537
],
[
537,
40,
830
]
],
[
[
1442,
63,
1219
],
[
1219,
40,
830
]
],
[
[
1442,
63,
357
],
[
357,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compound... |
DB00761 | DB00782 | 1,621 | 1,123 | [
"DDInter1497",
"DDInter1535"
] | Potassium chloride | Propantheline | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Major | 2 | [
[
[
1621,
25,
1123
]
],
[
[
1621,
21,
28714
],
[
28714,
60,
1123
]
],
[
[
1621,
25,
776
],
[
776,
63,
1123
]
],
[
[
1621,
64,
999
],
[
999... | [
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Propantheline"
]
],
[
[
"Potassium chloride",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is ca... | Potassium chloride (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Propantheline (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Molindone and Molindone may cause a moderate interaction that could exacerbate diseases when taken with Propant... |
DB01166 | DB09030 | 477 | 840 | [
"DDInter379",
"DDInter1945"
] | Cilostazol | Vorapaxar | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Moderate | 1 | [
[
[
477,
24,
840
]
],
[
[
477,
23,
944
],
[
944,
62,
840
]
],
[
[
477,
24,
765
],
[
765,
24,
840
]
],
[
[
477,
63,
1416
],
[
1416,
2... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorapaxar"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a ... |
DB00581 | DB00741 | 355 | 167 | [
"DDInter1018",
"DDInter885"
] | Lactulose | Hydrocortisone | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
355,
24,
167
]
],
[
[
355,
24,
1220
],
[
1220,
40,
167
]
],
[
[
355,
63,
443
],
[
443,
24,
167
]
],
[
[
355,
24,
870
],
[
870,
1... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a moderate intera... |
DB01241 | DB04951 | 1,206 | 187 | [
"DDInter812",
"DDInter1477"
] | Gemfibrozil | Pirfenidone | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
1206,
24,
187
]
],
[
[
1206,
24,
1017
],
[
1017,
63,
187
]
],
[
[
1206,
63,
663
],
[
663,
24,
187
]
],
[
[
1206,
24,
1017
],
[
1017,
... | [
[
[
"Gemfibrozil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Gemfibrozil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[... | Gemfibrozil may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone
Gemfibrozil may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and M... |
DB01267 | DB13074 | 519 | 877 | [
"DDInter1381",
"DDInter1110"
] | Paliperidone | Macimorelin | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
519,
25,
877
]
],
[
[
519,
62,
112
],
[
112,
23,
877
]
],
[
[
519,
63,
85
],
[
85,
24,
877
]
],
[
[
519,
24,
913
],
[
913,
24,
... | [
[
[
"Paliperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Paliperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Paliperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Atropine and A... |
DB00559 | DB11921 | 152 | 1,019 | [
"DDInter223",
"DDInter492"
] | Bosentan | Deflazacort | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
152,
25,
1019
]
],
[
[
152,
24,
959
],
[
959,
24,
1019
]
],
[
[
152,
24,
1619
],
[
1619,
63,
1019
]
],
[
[
152,
63,
1324
],
[
1324,
... | [
[
[
"Bosentan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
"Glipizide",
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib ma... |
DB00059 | DB06822 | 1,560 | 802 | [
"DDInter1404",
"DDInter1812"
] | Pegaspargase | Tinzaparin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Moderate | 1 | [
[
[
1560,
24,
802
]
],
[
[
1560,
24,
1603
],
[
1603,
24,
802
]
],
[
[
1560,
24,
1496
],
[
1496,
63,
802
]
],
[
[
1560,
24,
1347
],
[
1347,... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Captopril and Captopril may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nint... |
DB01309 | DB09128 | 1,254 | 1,241 | [
"DDInter933",
"DDInter231"
] | Insulin glulisine | Brexpiprazole | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
1254,
24,
1241
]
],
[
[
1254,
24,
549
],
[
549,
24,
1241
]
],
[
[
1254,
63,
170
],
[
170,
24,
1241
]
],
[
[
1254,
62,
274
],
[
274,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflo... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00245 | DB04837 | 357 | 649 | [
"DDInter181",
"DDInter407"
] | Benzatropine | Clofedanol | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
357,
24,
649
]
],
[
[
357,
24,
1376
],
[
1376,
24,
649
]
],
[
[
357,
24,
832
],
[
832,
40,
649
]
],
[
[
357,
1,
358
],
[
358,
24... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],... | Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Tripele... |
DB00357 | DB12010 | 1,051 | 214 | [
"DDInter71",
"DDInter785"
] | Aminoglutethimide | Fostamatinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1051,
24,
214
]
],
[
[
1051,
24,
976
],
[
976,
24,
214
]
],
[
[
1051,
24,
861
],
[
861,
63,
214
]
],
[
[
1051,
25,
879
],
[
879,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Rip... |
DB00106 | DB09020 | 618 | 28 | [
"DDInter4",
"DDInter212"
] | Abarelix | Bisacodyl | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
618,
24,
28
]
],
[
[
618,
25,
540
],
[
540,
24,
28
]
],
[
[
618,
24,
938
],
[
938,
63,
28
]
],
[
[
618,
24,
534
],
[
534,
24,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
],
[
"Dronedarone",
... | Abarelix may lead to a major life threatening interaction when taken with Dronedarone and Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant and Pitolisant may cause a m... |
DB00835 | DB01043 | 100 | 108 | [
"DDInter245",
"DDInter1146"
] | Brompheniramine | Memantine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in ... | Moderate | 1 | [
[
[
100,
24,
108
]
],
[
[
100,
6,
10215
],
[
10215,
45,
108
]
],
[
[
100,
63,
506
],
[
506,
23,
108
]
],
[
[
100,
24,
1264
],
[
1264,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Memantine"
]
],
[
[
"Brompheniramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (... | Brompheniramine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Memantine (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a minor interaction that can limit clinical effects when taken with Memantin... |
DB08899 | DB11921 | 129 | 1,019 | [
"DDInter649",
"DDInter492"
] | Enzalutamide | Deflazacort | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
129,
25,
1019
]
],
[
[
129,
24,
192
],
[
192,
24,
1019
]
],
[
[
129,
63,
959
],
[
959,
24,
1019
]
],
[
[
129,
24,
1619
],
[
1619,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
],
[
... | Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens and Esterified estrogens may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00777 | DB01278 | 146 | 1,021 | [
"DDInter1537",
"DDInter1506"
] | Propiomazine | Pramlintide | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
146,
24,
1021
]
],
[
[
146,
24,
1507
],
[
1507,
24,
1021
]
],
[
[
146,
40,
9
],
[
9,
63,
1021
]
],
[
[
146,
24,
22
],
[
22,
63,
... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Propiomazine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine may cause a moderate i... |
DB00060 | DB00881 | 912 | 954 | [
"DDInter947",
"DDInter1554"
] | Interferon beta-1a | Quinapril | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
912,
24,
954
]
],
[
[
912,
24,
1638
],
[
1638,
1,
954
]
],
[
[
912,
24,
1523
],
[
1523,
40,
954
]
],
[
[
912,
63,
1648
],
[
1648,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Quina... |
DB00104 | DB11835 | 966 | 1,345 | [
"DDInter1323",
"DDInter920"
] | Octreotide | Indium In-111 pentetreotide | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Indium In 111 pentetreotide (Octreoscan) has been used in trials studying the diagnostic of SARCOIDOSIS, Solid Tumors, and cushing syndrome. | Moderate | 1 | [
[
[
966,
24,
1345
]
],
[
[
966,
23,
466
],
[
466,
62,
1446
],
[
1446,
24,
1345
]
],
[
[
966,
24,
469
],
[
469,
24,
1446
],
[
1446,
24,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 pentetreotide"
]
],
[
[
"Octreotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide... | Octreotide may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Lanreotide and Lanreotide may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 pen... |
DB00960 | DB01050 | 887 | 848 | [
"DDInter1471",
"DDInter900"
] | Pindolol | Ibuprofen | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
887,
24,
848
]
],
[
[
887,
1,
1248
],
[
1248,
1,
848
]
],
[
[
887,
24,
1053
],
[
1053,
1,
848
]
],
[
[
887,
7,
5066
],
[
5066,
4... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Pindolol",
"{u} (Compound) resembles {v} (Compound)",
"Atenolol"
],
[
"Atenolol",
"{u} (Compound) resembles {v} (Co... | Pindolol (Compound) resembles Atenolol (Compound) and Atenolol (Compound) resembles Ibuprofen (Compound)
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Pindolol (Compound) upregulates CXCL8 (Gene) and CXCL8... |
DB00867 | DB06176 | 1,052 | 1,342 | [
"DDInter1606",
"DDInter1616"
] | Ritodrine | Romidepsin | Adrenergic beta-agonist used to control premature labor. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1052,
24,
1342
]
],
[
[
1052,
63,
485
],
[
485,
24,
1342
]
],
[
[
1052,
24,
1520
],
[
1520,
24,
1342
]
],
[
[
1052,
24,
1616
],
[
1616... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaq... |
DB00489 | DB08871 | 17 | 36 | [
"DDInter1704",
"DDInter666"
] | Sotalol | Eribulin | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
17,
25,
36
]
],
[
[
17,
64,
1424
],
[
1424,
24,
36
]
],
[
[
17,
25,
820
],
[
820,
24,
36
]
],
[
[
17,
36,
1674
],
[
1674,
24,
... | [
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
],
[
"Quinine",
"{u} may cause a mod... | Sotalol may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Sotalol may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a moderate interaction that... |
DB00286 | DB06203 | 380 | 1,002 | [
"DDInter439",
"DDInter51"
] | Conjugated estrogens | Alogliptin | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
380,
24,
1002
]
],
[
[
380,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
380,
6,
8374
],
[
8374,
45,
1002
]
],
[
[
380,
21,
28873
],
[
28873,... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagli... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Conjugated estrogens (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alogliptin (Compound)
Conjugated estrogens (Compound) causes Pancr... |
DB00685 | DB14491 | 1,299 | 428 | [
"DDInter1887",
"DDInter725"
] | Trovafloxacin | Ferrous fumarate | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
1299,
24,
428
]
],
[
[
1299,
24,
1096
],
[
1096,
23,
428
]
],
[
[
1299,
1,
872
],
[
872,
24,
428
]
],
[
[
1299,
24,
1384
],
[
1384,
... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic ac... | Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Trovafloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a mod... |
DB00366 | DB00496 | 1,594 | 194 | [
"DDInter600",
"DDInter480"
] | Doxylamine | Darifenacin | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Moderate | 1 | [
[
[
1594,
24,
194
]
],
[
[
1594,
24,
704
],
[
704,
1,
194
]
],
[
[
1594,
24,
1511
],
[
1511,
63,
194
]
],
[
[
1594,
74,
576
],
[
576,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darifenacin"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Darifenacin (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could ... |
DB00982 | DB05812 | 1,517 | 1,374 | [
"DDInter991",
"DDInter8"
] | Isotretinoin | Abiraterone | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1517,
24,
1374
]
],
[
[
1517,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
1517,
63,
188
],
[
188,
24,
1374
]
],
[
[
1517,
24,
1619
],
[
16... | [
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Isotretinoin",
"{u} (Compound) causes {v} (Side Effect)",
"Acute coronary syndrome"
],
[
"Acute coronary syndrome",... | Isotretinoin (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Nevirapine and Nevirapine may cause a moderate interaction that could exacerbate... |
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