drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00370 | DB09065 | 1,251 | 760 | [
"DDInter1230",
"DDInter424"
] | Mirtazapine | Cobicistat | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1251,
24,
760
]
],
[
[
1251,
63,
1101
],
[
1101,
23,
760
]
],
[
[
1251,
24,
1374
],
[
1374,
23,
760
]
],
[
[
1251,
24,
723
],
[
723,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abira... |
DB00047 | DB00759 | 176 | 1,620 | [
"DDInter932",
"DDInter1783"
] | Insulin glargine | Tetracycline | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Moderate | 1 | [
[
[
176,
24,
1620
]
],
[
[
176,
24,
1572
],
[
1572,
40,
1620
]
],
[
[
176,
24,
1326
],
[
1326,
62,
1620
]
],
[
[
176,
24,
811
],
[
811,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocyclin... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide may cause a min... |
DB00694 | DB00757 | 51 | 1,166 | [
"DDInter485",
"DDInter581"
] | Daunorubicin | Dolasetron | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
51,
25,
1166
]
],
[
[
51,
6,
8374
],
[
8374,
45,
1166
]
],
[
[
51,
7,
6952
],
[
6952,
46,
1166
]
],
[
[
51,
21,
28803
],
[
28803,
... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Daunorubicin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Dol... | Daunorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dolasetron (Compound)
Daunorubicin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Dolasetron (Compound)
Daunorubicin (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Dolasetron (Compound)
Da... |
DB00668 | DB00983 | 874 | 480 | [
"DDInter652",
"DDInter776"
] | Epinephrine | Formoterol | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
874,
24,
480
]
],
[
[
874,
24,
1148
],
[
1148,
63,
480
]
],
[
[
874,
64,
1523
],
[
1523,
25,
480
]
],
[
[
874,
40,
1188
],
[
1188,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Epinephrine may lead to a major life threatening interaction when taken with Labetalol and Labetalol may le... |
DB00316 | DB04843 | 474 | 1,511 | [
"DDInter14",
"DDInter1149"
] | Acetaminophen | Mepenzolate | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Minor | 0 | [
[
[
474,
23,
1511
]
],
[
[
474,
23,
1192
],
[
1192,
24,
1511
]
],
[
[
474,
62,
352
],
[
352,
24,
1511
]
],
[
[
474,
7,
12149
],
[
12149,
... | [
[
[
"Acetaminophen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mepenzolate"
]
],
[
[
"Acetaminophen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Glycopyrronium"
],
... | Acetaminophen may cause a minor interaction that can limit clinical effects when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Acetaminophen may cause a minor interaction that can limit clinical effects when taken with Trospium a... |
DB00280 | DB00877 | 494 | 629 | [
"DDInter575",
"DDInter1678"
] | Disopyramide | Sirolimus | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
494,
24,
629
]
],
[
[
494,
6,
8374
],
[
8374,
45,
629
]
],
[
[
494,
7,
16192
],
[
16192,
46,
629
]
],
[
[
494,
21,
28898
],
[
28898,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Disopyramide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Disopyramide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sirolimus (Compound)
Disopyramide (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Sirolimus (Compound)
Disopyramide (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Sirolimus (C... |
DB00679 | DB01168 | 684 | 1,053 | [
"DDInter1796",
"DDInter1526"
] | Thioridazine | Procarbazine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
684,
24,
1053
]
],
[
[
684,
18,
4930
],
[
4930,
57,
1053
]
],
[
[
684,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
684,
24,
480
],
[
480,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Thioridazine",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by ... | Thioridazine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Thioridazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with F... |
DB06663 | DB14568 | 1,154 | 982 | [
"DDInter1398",
"DDInter1000"
] | Pasireotide | Ivosidenib | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1154,
25,
982
]
],
[
[
1154,
62,
112
],
[
112,
23,
982
]
],
[
[
1154,
63,
608
],
[
608,
23,
982
]
],
[
[
1154,
63,
1081
],
[
1081,
... | [
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Pasireotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Pasireotide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lid... |
DB00902 | DB01023 | 104 | 409 | [
"DDInter1168",
"DDInter716"
] | Methdilazine | Felodipine | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
104,
24,
409
]
],
[
[
104,
63,
376
],
[
376,
40,
409
]
],
[
[
104,
63,
1428
],
[
1428,
1,
409
]
],
[
[
104,
24,
336
],
[
336,
40... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Felodipine (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Felodipine (Compou... |
DB00451 | DB08890 | 542 | 16 | [
"DDInter1064",
"DDInter1069"
] | Levothyroxine | Linaclotide | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin deri... | Moderate | 1 | [
[
[
542,
24,
16
]
],
[
[
542,
63,
1215
],
[
1215,
23,
16
]
],
[
[
542,
24,
379
],
[
379,
23,
16
]
],
[
[
542,
24,
286
],
[
286,
62,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linaclotide"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole ... |
DB06717 | DB11718 | 875 | 927 | [
"DDInter778",
"DDInter640"
] | Fosaprepitant | Encorafenib | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
875,
25,
927
]
],
[
[
875,
63,
1324
],
[
1324,
24,
927
]
],
[
[
875,
25,
484
],
[
484,
63,
927
]
],
[
[
875,
24,
578
],
[
578,
2... | [
[
[
"Fosaprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
"T... | Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Fosaprepitant may lead to a major life threatening interaction when taken with Entrectinib and Entrectin... |
DB00468 | DB01211 | 1,424 | 609 | [
"DDInter1557",
"DDInter393"
] | Quinine | Clarithromycin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
1424,
25,
609
]
],
[
[
1424,
63,
1570
],
[
1570,
24,
609
]
],
[
[
1424,
6,
4973
],
[
4973,
45,
609
]
],
[
[
1424,
18,
3106
],
[
3106,
... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
"Azithromyc... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Quinine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Quinine (Compo... |
DB00095 | DB09322 | 66 | 1,114 | [
"DDInter623",
"DDInter1966"
] | Efalizumab | Zinc sulfate | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Minor | 0 | [
[
[
66,
23,
1114
]
],
[
[
66,
24,
1093
],
[
1093,
62,
1114
]
],
[
[
66,
63,
1057
],
[
1057,
23,
1114
]
],
[
[
66,
24,
259
],
[
259,
... | [
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Etanercept and Etaner... |
DB00328 | DB01377 | 831 | 1,283 | [
"DDInter921",
"DDInter1119"
] | Indomethacin | Magnesium oxide | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
831,
23,
1283
]
],
[
[
831,
24,
167
],
[
167,
23,
1283
]
],
[
[
831,
25,
1468
],
[
1468,
62,
1283
]
],
[
[
831,
63,
1018
],
[
1018,
... | [
[
[
"Indomethacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Indomethacin may lead to a major life threatening interaction when taken with Ponatinib and Ponatin... |
DB01021 | DB11827 | 674 | 433 | [
"DDInter1861",
"DDInter669"
] | Trichlormethiazide | Ertugliflozin | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
674,
24,
433
]
],
[
[
674,
24,
959
],
[
959,
24,
433
]
],
[
[
674,
63,
251
],
[
251,
24,
433
]
],
[
[
674,
1,
1577
],
[
1577,
24... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizid... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Beta... |
DB00313 | DB00650 | 556 | 1,147 | [
"DDInter1913",
"DDInter1041"
] | Valproic acid | Leucovorin | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharma... | Moderate | 1 | [
[
[
556,
24,
1147
]
],
[
[
556,
63,
356
],
[
356,
1,
1147
]
],
[
[
556,
21,
28929
],
[
28929,
60,
1147
]
],
[
[
556,
24,
663
],
[
663,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Leucovorin"
]
],
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Folic acid"
],
... | Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Folic acid and Folic acid (Compound) resembles Leucovorin (Compound)
Valproic acid (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Leucovorin (Compound)
Valproic acid may caus... |
DB00872 | DB08816 | 1,080 | 578 | [
"DDInter438",
"DDInter1802"
] | Conivaptan | Ticagrelor | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Major | 2 | [
[
[
1080,
25,
578
]
],
[
[
1080,
6,
8374
],
[
8374,
45,
578
]
],
[
[
1080,
21,
28646
],
[
28646,
60,
578
]
],
[
[
1080,
1,
700
],
[
700,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticagrelor"
]
],
[
[
"Conivaptan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ticagre... | Conivaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Conivaptan (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Conivaptan (Compound) re... |
DB01100 | DB09073 | 1,568 | 951 | [
"DDInter1470",
"DDInter1379"
] | Pimozide | Palbociclib | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1568,
24,
951
]
],
[
[
1568,
24,
1476
],
[
1476,
63,
951
]
],
[
[
1568,
25,
159
],
[
159,
63,
951
]
],
[
[
1568,
64,
600
],
[
600,
... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Pimozide may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cau... |
DB00486 | DB01324 | 1,614 | 178 | [
"DDInter1253",
"DDInter1490"
] | Nabilone | Polythiazide | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
1614,
24,
178
]
],
[
[
1614,
24,
674
],
[
674,
40,
178
]
],
[
[
1614,
63,
323
],
[
323,
40,
178
]
],
[
[
1614,
21,
28852
],
[
28852,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
],
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide (Compound) ... |
DB00247 | DB11986 | 1,131 | 484 | [
"DDInter1194",
"DDInter648"
] | Methysergide | Entrectinib | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1131,
24,
484
]
],
[
[
1131,
24,
222
],
[
222,
23,
484
]
],
[
[
1131,
24,
1320
],
[
1320,
24,
484
]
],
[
[
1131,
40,
826
],
[
826,
... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Ela... |
DB00196 | DB00238 | 600 | 188 | [
"DDInter743",
"DDInter1285"
] | Fluconazole | Nevirapine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Moderate | 1 | [
[
[
600,
24,
188
]
],
[
[
600,
6,
7524
],
[
7524,
45,
188
]
],
[
[
600,
21,
28708
],
[
28708,
60,
188
]
],
[
[
600,
23,
1101
],
[
1101,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nevirapine"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)... | Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Nevirapine (Compound)
Fluconazole (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Nevirapine (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarot... |
DB00524 | DB01001 | 811 | 688 | [
"DDInter1199",
"DDInter1632"
] | Metolazone | Salbutamol | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
811,
24,
688
]
],
[
[
811,
24,
455
],
[
455,
24,
688
]
],
[
[
811,
21,
28714
],
[
28714,
60,
688
]
],
[
[
811,
24,
1220
],
[
1220,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Metolazone (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Salbutamol (Compound... |
DB05528 | DB09078 | 1,070 | 1,228 | [
"DDInter1228",
"DDInter1036"
] | Mipomersen | Lenvatinib | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1070,
25,
1228
]
],
[
[
1070,
64,
609
],
[
609,
24,
1228
]
],
[
[
1070,
25,
384
],
[
384,
24,
1228
]
],
[
[
1070,
25,
710
],
[
710,
... | [
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clarithromycin",
... | Mipomersen may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib
Mipomersen may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moder... |
DB01116 | DB01284 | 601 | 1,042 | [
"DDInter1872",
"DDInter1782"
] | Trimethaphan | Tetracosactide | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
601,
24,
1042
]
],
[
[
601,
24,
1450
],
[
1450,
63,
1042
]
],
[
[
601,
63,
1648
],
[
1648,
24,
1042
]
],
[
[
601,
24,
593
],
[
593,
... | [
[
[
"Trimethaphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Trimethaphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
... | Trimethaphan may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Trimethaphan may cause a moderate interaction that could exacerbate diseases when taken with Aldesle... |
DB06212 | DB06605 | 165 | 1,409 | [
"DDInter1833",
"DDInter108"
] | Tolvaptan | Apixaban | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
165,
24,
1409
]
],
[
[
165,
6,
4973
],
[
4973,
45,
1409
]
],
[
[
165,
21,
29034
],
[
29034,
60,
1409
]
],
[
[
165,
24,
1670
],
[
1670,... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Tolvaptan",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Tolvaptan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Apixaban (Compound)
Tolvaptan (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Apixaban (Compound)
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with El... |
DB01208 | DB01254 | 945 | 1,213 | [
"DDInter1705",
"DDInter484"
] | Sparfloxacin | Dasatinib | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
945,
25,
1213
]
],
[
[
945,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
945,
18,
4700
],
[
4700,
46,
1213
]
],
[
[
945,
18,
2183
],
[
2183,
... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Sparfloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasati... | Sparfloxacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Sparfloxacin (Compound) downregulates TCEA2 (Gene) and TCEA2 (Gene) is upregulated by Dasatinib (Compound)
Sparfloxacin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dasatinib (Compound)
Sparfloxaci... |
DB00427 | DB04953 | 1,233 | 495 | [
"DDInter1879",
"DDInter708"
] | Triprolidine | Ezogabine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
1233,
24,
495
]
],
[
[
1233,
24,
662
],
[
662,
24,
495
]
],
[
[
1233,
24,
1609
],
[
1609,
63,
495
]
],
[
[
1233,
63,
1594
],
[
1594,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Ezogabine
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverin... |
DB06016 | DB06292 | 1,508 | 549 | [
"DDInter300",
"DDInter474"
] | Cariprazine | Dapagliflozin | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1508,
24,
549
]
],
[
[
1508,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1508,
63,
1179
],
[
1179,
24,
549
]
],
[
[
1508,
24,
1017
],
[
1017,... | [
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and Insulin lispro may cause a moderate int... |
DB00486 | DB05541 | 1,614 | 801 | [
"DDInter1253",
"DDInter239"
] | Nabilone | Brivaracetam | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Moderate | 1 | [
[
[
1614,
24,
801
]
],
[
[
1614,
63,
475
],
[
475,
24,
801
]
],
[
[
1614,
24,
100
],
[
100,
24,
801
]
],
[
[
1614,
24,
407
],
[
407,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brivaracetam"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Brivaracetam
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Bromphe... |
DB08880 | DB12240 | 1,510 | 110 | [
"DDInter1771",
"DDInter1485"
] | Teriflunomide | Polatuzumab vedotin | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Major | 2 | [
[
[
1510,
25,
110
]
],
[
[
1510,
24,
129
],
[
129,
23,
110
]
],
[
[
1510,
64,
467
],
[
467,
24,
110
]
],
[
[
1510,
63,
597
],
[
597,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Teriflunomide may lead to a major life threatening interaction when taken with Simvastatin and Sim... |
DB01165 | DB01259 | 1,539 | 392 | [
"DDInter1325",
"DDInter1024"
] | Ofloxacin | Lapatinib | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1539,
24,
392
]
],
[
[
1539,
18,
4602
],
[
4602,
57,
392
]
],
[
[
1539,
21,
29429
],
[
29429,
60,
392
]
],
[
[
1539,
62,
112
],
[
112,... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Ofloxacin",
"{u} (Compound) downregulates {v} (Gene)",
"SUPV3L1"
],
[
"SUPV3L1",
"{u} (Gene) is downregulated by {... | Ofloxacin (Compound) downregulates SUPV3L1 (Gene) and SUPV3L1 (Gene) is downregulated by Lapatinib (Compound)
Ofloxacin (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (Compound)
Ofloxacin may cause a minor interaction that can limit clinical effects when taken w... |
DB00347 | DB11186 | 917 | 1,609 | [
"DDInter1871",
"DDInter1427"
] | Trimethadione | Pentoxyverine | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
917,
24,
1609
]
],
[
[
917,
24,
506
],
[
506,
24,
1609
]
],
[
[
917,
63,
701
],
[
701,
24,
1609
]
],
[
[
917,
24,
506
],
[
506,
... | [
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
... | Trimethadione may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Trimethadione may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00348 | DB01045 | 254 | 463 | [
"DDInter1300",
"DDInter1590"
] | Nitisinone | Rifampicin | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
254,
24,
463
]
],
[
[
254,
24,
690
],
[
690,
40,
463
]
],
[
[
254,
24,
1264
],
[
1264,
62,
463
]
],
[
[
254,
63,
1101
],
[
1101,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a minor interaction that can limit clinic... |
DB06176 | DB11791 | 1,342 | 785 | [
"DDInter1616",
"DDInter287"
] | Romidepsin | Capmatinib | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
1342,
24,
785
]
],
[
[
1342,
25,
868
],
[
868,
24,
785
]
],
[
[
1342,
63,
322
],
[
322,
24,
785
]
],
[
[
1342,
24,
98
],
[
98,
2... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafen... | Romidepsin may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may caus... |
DB00633 | DB00748 | 614 | 662 | [
"DDInter520",
"DDInter297"
] | Dexmedetomidine | Carbinoxamine | An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
614,
24,
662
]
],
[
[
614,
63,
1594
],
[
1594,
24,
662
]
],
[
[
614,
6,
12523
],
[
12523,
45,
662
]
],
[
[
614,
21,
28921
],
[
28921,
... | [
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
... | Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Dexmedetomidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Carbinoxamine (Compound)
De... |
DB00687 | DB01021 | 870 | 674 | [
"DDInter747",
"DDInter1861"
] | Fludrocortisone | Trichlormethiazide | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
870,
24,
674
]
],
[
[
870,
63,
1014
],
[
1014,
40,
674
]
],
[
[
870,
24,
178
],
[
178,
1,
674
]
],
[
[
870,
24,
359
],
[
359,
40... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiaz... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resemb... |
DB00631 | DB12010 | 372 | 214 | [
"DDInter405",
"DDInter785"
] | Clofarabine | Fostamatinib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
372,
24,
214
]
],
[
[
372,
25,
976
],
[
976,
24,
214
]
],
[
[
372,
24,
866
],
[
866,
24,
214
]
],
[
[
372,
63,
322
],
[
322,
24,... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Clofarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofac... | Clofarabine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib and Cobimetinib ma... |
DB06414 | DB08816 | 655 | 578 | [
"DDInter703",
"DDInter1802"
] | Etravirine | Ticagrelor | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
655,
24,
578
]
],
[
[
655,
6,
4973
],
[
4973,
45,
578
]
],
[
[
655,
21,
28646
],
[
28646,
60,
578
]
],
[
[
655,
24,
1135
],
[
1135,
... | [
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Etravirine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Etravirine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Etravirine (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Etravirine may cause a mod... |
DB00358 | DB12010 | 1,010 | 214 | [
"DDInter1140",
"DDInter785"
] | Mefloquine | Fostamatinib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1010,
24,
214
]
],
[
[
1010,
63,
1428
],
[
1428,
24,
214
]
],
[
[
1010,
24,
690
],
[
690,
24,
214
]
],
[
[
1010,
25,
924
],
[
924,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifab... |
DB00660 | DB11130 | 1,470 | 407 | [
"DDInter1163",
"DDInter1344"
] | Metaxalone | Opium | Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1470,
24,
407
]
],
[
[
1470,
24,
662
],
[
662,
24,
407
]
],
[
[
1470,
63,
1233
],
[
1233,
24,
407
]
],
[
[
1470,
64,
475
],
[
475,
... | [
[
[
"Metaxalone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Metaxalone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Metaxalone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Metaxalone may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine and Tri... |
DB00290 | DB00827 | 329 | 646 | [
"DDInter219",
"DDInter383"
] | Bleomycin | Cinoxacin | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Minor | 0 | [
[
[
329,
23,
646
]
],
[
[
329,
21,
28722
],
[
28722,
60,
646
]
],
[
[
329,
24,
77
],
[
77,
62,
646
]
],
[
[
329,
24,
322
],
[
322,
2... | [
[
[
"Bleomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cinoxacin"
]
],
[
[
"Bleomycin",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (... | Bleomycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Cinoxacin (Compound)
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Bleomyci... |
DB00220 | DB00773 | 798 | 896 | [
"DDInter1276",
"DDInter702"
] | Nelfinavir | Etoposide | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
798,
24,
896
]
],
[
[
798,
6,
7524
],
[
7524,
45,
896
]
],
[
[
798,
7,
7669
],
[
7669,
46,
896
]
],
[
[
798,
18,
2183
],
[
2183,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Nelfinavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Etoposide (Compound)
Nelfinavir (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Etoposide (Compound)
Nelfinavir (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Etoposide (Compound)
Nelfinavir (Compo... |
DB04953 | DB05294 | 495 | 1,069 | [
"DDInter708",
"DDInter1917"
] | Ezogabine | Vandetanib | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
495,
25,
1069
]
],
[
[
495,
21,
28921
],
[
28921,
60,
1069
]
],
[
[
495,
23,
1135
],
[
1135,
62,
1069
]
],
[
[
495,
62,
112
],
[
112,
... | [
[
[
"Ezogabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Ezogabine",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is caused by {v} (Compou... | Ezogabine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Vandetanib (Compound)
Ezogabine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Vandetanib
Ezog... |
DB00381 | DB00757 | 376 | 1,166 | [
"DDInter79",
"DDInter581"
] | Amlodipine | Dolasetron | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
376,
25,
1166
]
],
[
[
376,
6,
12523
],
[
12523,
45,
1166
]
],
[
[
376,
21,
29081
],
[
29081,
60,
1166
]
],
[
[
376,
24,
214
],
[
214,... | [
[
[
"Amlodipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Dolaset... | Amlodipine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dolasetron (Compound)
Amlodipine (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Dolasetron (Compound)
Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and ... |
DB00970 | DB10276 | 0 | 1,624 | [
"DDInter466",
"DDInter1623"
] | Dactinomycin | Rotavirus vaccine | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
0,
25,
1624
]
],
[
[
0,
24,
1307
],
[
1307,
25,
1624
]
],
[
[
0,
63,
1648
],
[
1648,
25,
1624
]
],
[
[
0,
25,
770
],
[
770,
25,
... | [
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
"... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may lead to a major life threatening interaction when taken with Rotavirus vaccine
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin... |
DB00328 | DB09030 | 831 | 840 | [
"DDInter921",
"DDInter1945"
] | Indomethacin | Vorapaxar | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
831,
25,
840
]
],
[
[
831,
24,
885
],
[
885,
24,
840
]
],
[
[
831,
24,
1017
],
[
1017,
63,
840
]
],
[
[
831,
63,
702
],
[
702,
2... | [
[
[
"Indomethacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
"Epopr... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and... |
DB00631 | DB01208 | 372 | 945 | [
"DDInter405",
"DDInter1705"
] | Clofarabine | Sparfloxacin | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
372,
23,
945
]
],
[
[
372,
23,
739
],
[
739,
1,
945
]
],
[
[
372,
63,
1176
],
[
1176,
1,
945
]
],
[
[
372,
18,
3199
],
[
3199,
4... | [
[
[
"Clofarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Clofarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Clofarabine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin... |
DB00704 | DB00963 | 267 | 1,263 | [
"DDInter1263",
"DDInter241"
] | Naltrexone | Bromfenac | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
267,
24,
1263
]
],
[
[
267,
24,
935
],
[
935,
40,
1263
]
],
[
[
267,
63,
831
],
[
831,
40,
1263
]
],
[
[
267,
63,
1512
],
[
1512,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Bromfenac (Compound... |
DB00039 | DB00619 | 1,253 | 1,419 | [
"DDInter1380",
"DDInter909"
] | Palifermin | Imatinib | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
1253,
24,
1419
]
],
[
[
1253,
24,
1101
],
[
1101,
23,
1419
]
],
[
[
1253,
24,
309
],
[
309,
63,
1419
]
],
[
[
1253,
24,
599
],
[
599,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Imatinib
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilo... |
DB01118 | DB08916 | 33 | 26 | [
"DDInter76",
"DDInter32"
] | Amiodarone | Afatinib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
33,
24,
26
]
],
[
[
33,
63,
883
],
[
883,
40,
26
]
],
[
[
33,
6,
4973
],
[
4973,
45,
26
]
],
[
[
33,
7,
8733
],
[
8733,
46,
... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Amiodarone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Amiodarone (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is upregul... |
DB00041 | DB00262 | 1,648 | 552 | [
"DDInter38",
"DDInter302"
] | Aldesleukin | Carmustine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Moderate | 1 | [
[
[
1648,
24,
552
]
],
[
[
1648,
23,
739
],
[
739,
62,
552
]
],
[
[
1648,
23,
1176
],
[
1176,
23,
552
]
],
[
[
1648,
24,
729
],
[
729,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Carmustine
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxi... |
DB01064 | DB11632 | 1,148 | 580 | [
"DDInter987",
"DDInter1343"
] | Isoprenaline | Opicapone | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) in... | Moderate | 1 | [
[
[
1148,
24,
580
]
],
[
[
1148,
24,
401
],
[
401,
24,
580
]
],
[
[
1148,
63,
874
],
[
874,
24,
580
]
],
[
[
1148,
24,
1053
],
[
1053,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opicapone"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine an... |
DB00060 | DB00356 | 912 | 1,315 | [
"DDInter947",
"DDInter366"
] | Interferon beta-1a | Chlorzoxazone | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) | Moderate | 1 | [
[
[
912,
24,
1315
]
],
[
[
912,
24,
267
],
[
267,
63,
1315
]
],
[
[
912,
63,
1648
],
[
1648,
24,
1315
]
],
[
[
912,
24,
482
],
[
482,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorzoxazone"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexo... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Chlorzoxazone
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Al... |
DB00902 | DB01162 | 104 | 195 | [
"DDInter1168",
"DDInter1767"
] | Methdilazine | Terazosin | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Moderate | 1 | [
[
[
104,
24,
195
]
],
[
[
104,
63,
1205
],
[
1205,
40,
195
]
],
[
[
104,
63,
475
],
[
475,
24,
195
]
],
[
[
104,
24,
401
],
[
401,
2... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terazosin"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prazosin"
],
[
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Prazosin and Prazosin (Compound) resembles Terazosin (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exac... |
DB09078 | DB11730 | 1,228 | 351 | [
"DDInter1036",
"DDInter1588"
] | Lenvatinib | Ribociclib | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1228,
25,
351
]
],
[
[
1228,
62,
1247
],
[
1247,
23,
351
]
],
[
[
1228,
63,
1627
],
[
1627,
23,
351
]
],
[
[
1228,
63,
355
],
[
355,
... | [
[
[
"Lenvatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Lenvatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfam... | Lenvatinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol a... |
DB00581 | DB00994 | 355 | 361 | [
"DDInter1018",
"DDInter1277"
] | Lactulose | Neomycin | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Minor | 0 | [
[
[
355,
23,
361
]
],
[
[
355,
40,
138
],
[
138,
1,
361
]
],
[
[
355,
1,
437
],
[
437,
40,
361
]
],
[
[
355,
40,
1647
],
[
1647,
24,... | [
[
[
"Lactulose",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Neomycin"
]
],
[
[
"Lactulose",
"{u} (Compound) resembles {v} (Compound)",
"Tobramycin"
],
[
"Tobramycin",
"{u} (Compound) resembles {v} ... | Lactulose (Compound) resembles Tobramycin (Compound) and Tobramycin (Compound) resembles Neomycin (Compound)
Lactulose (Compound) resembles Amikacin (Compound) and Amikacin (Compound) resembles Neomycin (Compound)
Lactulose (Compound) resembles Acarbose (Compound) and Acarbose may cause a moderate interaction that coul... |
DB00880 | DB01105 | 359 | 222 | [
"DDInter360",
"DDInter1665"
] | Chlorothiazide | Sibutramine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
359,
24,
222
]
],
[
[
359,
21,
28852
],
[
28852,
60,
222
]
],
[
[
359,
24,
659
],
[
659,
63,
222
]
],
[
[
359,
40,
1014
],
[
1014,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Chlorothiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Leukopenia"
],
[
"Leukopenia",
"{u} (Side Effe... | Chlorothiazide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutramine (Compound)
Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken w... |
DB05239 | DB06643 | 866 | 1,136 | [
"DDInter425",
"DDInter500"
] | Cobimetinib | Denosumab | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
866,
24,
1136
]
],
[
[
866,
63,
1213
],
[
1213,
24,
1136
]
],
[
[
866,
64,
1419
],
[
1419,
24,
1136
]
],
[
[
866,
25,
1510
],
[
1510,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Cobimetinib may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a mod... |
DB00046 | DB00795 | 1,179 | 50 | [
"DDInter940",
"DDInter1725"
] | Insulin lispro | Sulfasalazine | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
1179,
24,
50
]
],
[
[
1179,
24,
161
],
[
161,
1,
50
]
],
[
[
1179,
63,
305
],
[
305,
24,
50
]
],
[
[
1179,
24,
590
],
[
590,
24,... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfasalazine (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escheri... |
DB00374 | DB05773 | 1,061 | 1,047 | [
"DDInter1852",
"DDInter1848"
] | Treprostinil | Trastuzumab emtansine | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
1061,
24,
1047
]
],
[
[
1061,
24,
848
],
[
848,
24,
1047
]
],
[
[
1061,
24,
643
],
[
643,
63,
1047
]
],
[
[
1061,
63,
1230
],
[
1230,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Desvenla... |
DB00361 | DB01110 | 134 | 86 | [
"DDInter1939",
"DDInter1209"
] | Vinorelbine | Miconazole | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
134,
24,
86
]
],
[
[
134,
7,
8784
],
[
8784,
45,
86
]
],
[
[
134,
6,
4973
],
[
4973,
45,
86
]
],
[
[
134,
18,
5415
],
[
5415,
46... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Vinorelbine",
"{u} (Compound) upregulates {v} (Gene)",
"CYP51A1"
],
[
"CYP51A1",
"{u} (Gene) is bound by {v} (C... | Vinorelbine (Compound) upregulates CYP51A1 (Gene) and CYP51A1 (Gene) is bound by Miconazole (Compound)
Vinorelbine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Miconazole (Compound)
Vinorelbine (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Miconazole (Compound)
Vinorelbine (Co... |
DB01097 | DB06810 | 1,377 | 397 | [
"DDInter1033",
"DDInter1484"
] | Leflunomide | Plicamycin | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Major | 2 | [
[
[
1377,
25,
397
]
],
[
[
1377,
64,
1299
],
[
1299,
23,
397
]
],
[
[
1377,
63,
597
],
[
597,
24,
397
]
],
[
[
1377,
24,
151
],
[
151,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Plicamycin"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trovafloxacin"
],
[
"Trovafloxacin",
... | Leflunomide may lead to a major life threatening interaction when taken with Trovafloxacin and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Plicamycin
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphe... |
DB00321 | DB06699 | 21 | 774 | [
"DDInter78",
"DDInter493"
] | Amitriptyline | Degarelix | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
21,
24,
774
]
],
[
[
21,
63,
521
],
[
521,
1,
774
]
],
[
[
21,
21,
29232
],
[
29232,
60,
774
]
],
[
[
21,
23,
112
],
[
112,
23,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Amitriptyline (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Amitriptyline may cause a minor interactio... |
DB00387 | DB01176 | 1,386 | 537 | [
"DDInter1528",
"DDInter453"
] | Procyclidine | Cyclizine | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1386,
24,
537
]
],
[
[
1386,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1386,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1386,
40,
11268
],
[
1126... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and C... |
DB00792 | DB01168 | 832 | 1,053 | [
"DDInter1878",
"DDInter1526"
] | Tripelennamine | Procarbazine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
832,
24,
1053
]
],
[
[
832,
24,
100
],
[
100,
24,
1053
]
],
[
[
832,
24,
1311
],
[
1311,
63,
1053
]
],
[
[
832,
35,
272
],
[
272,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB00472 | DB01225 | 758 | 500 | [
"DDInter758",
"DDInter645"
] | Fluoxetine | Enoxaparin | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Moderate | 1 | [
[
[
758,
24,
500
]
],
[
[
758,
21,
29173
],
[
29173,
60,
500
]
],
[
[
758,
25,
1039
],
[
1039,
24,
500
]
],
[
[
758,
24,
1151
],
[
1151,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxaparin"
]
],
[
[
"Fluoxetine",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema peripheral"
],
[
"Oedema peripheral",
"{u} (Side... | Fluoxetine (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Enoxaparin (Compound)
Fluoxetine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00222 | DB00999 | 245 | 504 | [
"DDInter825",
"DDInter883"
] | Glimepiride | Hydrochlorothiazide | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
245,
24,
504
]
],
[
[
245,
24,
1326
],
[
1326,
40,
504
]
],
[
[
245,
24,
178
],
[
178,
1,
504
]
],
[
[
245,
21,
28779
],
[
28779,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles H... |
DB00454 | DB09472 | 1,349 | 1,383 | [
"DDInter1150",
"DDInter1693"
] | Meperidine | Sodium sulfate | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1349,
24,
1383
]
],
[
[
1349,
24,
1311
],
[
1311,
24,
1383
]
],
[
[
1349,
25,
1133
],
[
1133,
24,
1383
]
],
[
[
1349,
64,
1494
],
[
14... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
... | Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Meperidine may lead to a major life threatening interaction when taken with Granisetron and Graniset... |
DB00701 | DB08870 | 1,091 | 850 | [
"DDInter90",
"DDInter228"
] | Amprenavir | Brentuximab vedotin | Amprenavir is a protease inhibitor used to treat HIV infection. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1091,
24,
850
]
],
[
[
1091,
24,
1142
],
[
1142,
24,
850
]
],
[
[
1091,
64,
134
],
[
134,
24,
850
]
],
[
[
1091,
63,
883
],
[
883,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
],
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Amprenavir may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine may... |
DB00719 | DB00996 | 1,219 | 1,198 | [
"DDInter149",
"DDInter791"
] | Azatadine | Gabapentin | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to tr... | Moderate | 1 | [
[
[
1219,
24,
1198
]
],
[
[
1219,
24,
1311
],
[
1311,
63,
1198
]
],
[
[
1219,
63,
530
],
[
530,
24,
1198
]
],
[
[
1219,
24,
662
],
[
662,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gabapentin"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Gabapentin
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and ... |
DB00361 | DB11732 | 134 | 1,097 | [
"DDInter1939",
"DDInter1027"
] | Vinorelbine | Lasmiditan | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
134,
24,
1097
]
],
[
[
134,
24,
971
],
[
971,
63,
1097
]
],
[
[
134,
24,
77
],
[
77,
24,
1097
]
],
[
[
134,
25,
384
],
[
384,
24... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and ... |
DB00023 | DB12674 | 305 | 975 | [
"DDInter127",
"DDInter1105"
] | Asparaginase Escherichia coli | Lurbinectedin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
305,
24,
975
]
],
[
[
305,
24,
1613
],
[
1613,
24,
975
]
],
[
[
305,
24,
159
],
[
159,
63,
975
]
],
[
[
305,
63,
1257
],
[
1257,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Asparaginase Escherichia coli may cause a moderate interaction that ... |
DB11915 | DB12010 | 1,293 | 214 | [
"DDInter1909",
"DDInter785"
] | Valbenazine | Fostamatinib | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1293,
24,
214
]
],
[
[
1293,
63,
51
],
[
51,
24,
214
]
],
[
[
1293,
24,
1421
],
[
1421,
63,
214
]
],
[
[
1293,
64,
1166
],
[
1166,
... | [
[
[
"Valbenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Valbenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
... | Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban an... |
DB00620 | DB10795 | 175 | 221 | [
"DDInter1855",
"DDInter1486"
] | Triamcinolone | Poliovirus type 1 antigen (formaldehyde inactivated) | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
175,
24,
221
]
],
[
[
175,
64,
581
],
[
581,
24,
221
]
],
[
[
175,
63,
599
],
[
599,
24,
221
]
],
[
[
175,
40,
1486
],
[
1486,
2... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Triamcinolone may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when... |
DB11691 | DB14975 | 1,499 | 988 | [
"DDInter1258",
"DDInter1949"
] | Naldemedine | Voxelotor | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Moderate | 1 | [
[
[
1499,
24,
988
]
],
[
[
1499,
63,
1362
],
[
1362,
24,
988
]
],
[
[
1499,
24,
971
],
[
971,
24,
988
]
],
[
[
1499,
25,
913
],
[
913,
... | [
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxelotor"
]
],
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Voxelotor
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteri... |
DB02701 | DB08870 | 1,632 | 850 | [
"DDInter1289",
"DDInter228"
] | Nicotinamide | Brentuximab vedotin | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1632,
24,
850
]
],
[
[
1632,
63,
267
],
[
267,
24,
850
]
],
[
[
1632,
24,
1412
],
[
1412,
63,
850
]
],
[
[
1632,
24,
549
],
[
549,
... | [
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Calaspar... |
DB01088 | DB01254 | 714 | 1,213 | [
"DDInter908",
"DDInter484"
] | Iloprost | Dasatinib | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
714,
25,
1213
]
],
[
[
714,
23,
539
],
[
539,
62,
1213
]
],
[
[
714,
24,
738
],
[
738,
63,
1213
]
],
[
[
714,
63,
383
],
[
383,
... | [
[
[
"Iloprost",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Iloprost",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
"{... | Iloprost may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dasatinib
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause ... |
DB01110 | DB04868 | 86 | 478 | [
"DDInter1209",
"DDInter1293"
] | Miconazole | Nilotinib | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
86,
24,
478
]
],
[
[
86,
24,
1468
],
[
1468,
63,
478
]
],
[
[
86,
6,
6017
],
[
6017,
45,
478
]
],
[
[
86,
7,
2692
],
[
2692,
45,... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Miconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Miconazole (Compound) ... |
DB00530 | DB08873 | 1,195 | 74 | [
"DDInter667",
"DDInter221"
] | Erlotinib | Boceprevir | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
1195,
24,
74
]
],
[
[
1195,
6,
4973
],
[
4973,
45,
74
]
],
[
[
1195,
21,
28821
],
[
28821,
60,
74
]
],
[
[
1195,
24,
86
],
[
86,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Erlotinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Erlotinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Boceprevir (Compound)
Erlotinib (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Boceprevir (Compound)
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Miconazole may ... |
DB06616 | DB08903 | 594 | 996 | [
"DDInter224",
"DDInter170"
] | Bosutinib | Bedaquiline | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
594,
25,
996
]
],
[
[
594,
6,
8374
],
[
8374,
45,
996
]
],
[
[
594,
21,
29267
],
[
29267,
60,
996
]
],
[
[
594,
62,
112
],
[
112,
... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Bosutinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bedaquil... | Bosutinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Bosutinib (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Bedaquiline (Compound)
Bosutinib may cause a minor interaction that can limit clini... |
DB00188 | DB00227 | 168 | 1,463 | [
"DDInter222",
"DDInter1098"
] | Bortezomib | Lovastatin | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Moderate | 1 | [
[
[
168,
24,
1463
]
],
[
[
168,
63,
681
],
[
681,
1,
1463
]
],
[
[
168,
6,
6017
],
[
6017,
45,
1463
]
],
[
[
168,
7,
3603
],
[
3603,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pravastatin"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Pravastatin and Pravastatin (Compound) resembles Lovastatin (Compound)
Bortezomib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Lovastatin (Compound)
Bortezomib (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) ... |
DB00361 | DB00701 | 134 | 1,091 | [
"DDInter1939",
"DDInter90"
] | Vinorelbine | Amprenavir | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Amprenavir is a protease inhibitor used to treat HIV infection. | Major | 2 | [
[
[
134,
25,
1091
]
],
[
[
134,
25,
34
],
[
34,
1,
1091
]
],
[
[
134,
6,
4973
],
[
4973,
45,
1091
]
],
[
[
134,
21,
28996
],
[
28996,
... | [
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
]
],
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosamprenavir"
],
[
"Fosamprenavir",
... | Vinorelbine may lead to a major life threatening interaction when taken with Fosamprenavir and Fosamprenavir (Compound) resembles Amprenavir (Compound)
Vinorelbine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amprenavir (Compound)
Vinorelbine (Compound) causes Musculoskeletal discomfort (Side Effect) and ... |
DB00188 | DB09276 | 168 | 381 | [
"DDInter222",
"DDInter1682"
] | Bortezomib | Sodium aurothiomalate | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
168,
24,
381
]
],
[
[
168,
24,
1683
],
[
1683,
24,
381
]
],
[
[
168,
63,
491
],
[
491,
24,
381
]
],
[
[
168,
25,
375
],
[
375,
2... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Peginter... |
DB00738 | DB01601 | 485 | 833 | [
"DDInter1420",
"DDInter1089"
] | Pentamidine | Lopinavir | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Moderate | 1 | [
[
[
485,
24,
833
]
],
[
[
485,
25,
1327
],
[
1327,
40,
833
]
],
[
[
485,
6,
7950
],
[
7950,
45,
833
]
],
[
[
485,
18,
7374
],
[
7374,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
]
],
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
],
[
"Saquinavi... | Pentamidine may lead to a major life threatening interaction when taken with Saquinavir and Saquinavir (Compound) resembles Lopinavir (Compound)
Pentamidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Lopinavir (Compound)
Pentamidine (Compound) downregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated... |
DB00427 | DB00450 | 1,233 | 78 | [
"DDInter1879",
"DDInter603"
] | Triprolidine | Droperidol | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Moderate | 1 | [
[
[
1233,
24,
78
]
],
[
[
1233,
24,
1300
],
[
1300,
40,
78
]
],
[
[
1233,
24,
1568
],
[
1568,
1,
78
]
],
[
[
1233,
24,
506
],
[
506,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Haloperidol"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Haloperidol and Haloperidol (Compound) resembles Droperidol (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Pimozide and Pimozide (Compound) resembles Droperidol (Compound... |
DB00790 | DB01097 | 664 | 1,377 | [
"DDInter1431",
"DDInter1033"
] | Perindopril | Leflunomide | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
664,
25,
1377
]
],
[
[
664,
21,
29062
],
[
29062,
60,
1377
]
],
[
[
664,
24,
959
],
[
959,
24,
1377
]
],
[
[
664,
24,
1411
],
[
1411,
... | [
[
[
"Perindopril",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Perindopril",
"{u} (Compound) causes {v} (Side Effect)",
"Neutropenia"
],
[
"Neutropenia",
"{u} (Side Effect) is caused by {v... | Perindopril (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound)
Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Le... |
DB00372 | DB01100 | 999 | 1,568 | [
"DDInter1793",
"DDInter1470"
] | Thiethylperazine | Pimozide | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
999,
24,
1568
]
],
[
[
999,
24,
78
],
[
78,
40,
1568
]
],
[
[
999,
24,
19
],
[
19,
24,
1568
]
],
[
[
999,
23,
286
],
[
286,
63,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
]... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interactio... |
DB12130 | DB12457 | 1,017 | 1,180 | [
"DDInter1094",
"DDInter1598"
] | Lorlatinib | Rimegepant | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Major | 2 | [
[
[
1017,
25,
1180
]
],
[
[
1017,
63,
741
],
[
741,
24,
1180
]
],
[
[
1017,
24,
1619
],
[
1619,
24,
1180
]
],
[
[
1017,
25,
283
],
[
283,
... | [
[
[
"Lorlatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rimegepant"
]
],
[
[
"Lorlatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
[
"Rolapitant... | Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucapar... |
DB00621 | DB00631 | 1,026 | 372 | [
"DDInter1357",
"DDInter405"
] | Oxandrolone | Clofarabine | A synthetic hormone with anabolic and androgenic properties. | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
1026,
24,
372
]
],
[
[
1026,
7,
13720
],
[
13720,
46,
372
]
],
[
[
1026,
21,
29233
],
[
29233,
60,
372
]
],
[
[
1026,
63,
1560
],
[
15... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Oxandrolone",
"{u} (Compound) upregulates {v} (Gene)",
"TMEM2"
],
[
"TMEM2",
"{u} (Gene) is upregulated by {v}... | Oxandrolone (Compound) upregulates TMEM2 (Gene) and TMEM2 (Gene) is upregulated by Clofarabine (Compound)
Oxandrolone (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Clofarabine (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate disease... |
DB01364 | DB09038 | 22 | 1,450 | [
"DDInter650",
"DDInter636"
] | Ephedrine | Empagliflozin | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
22,
24,
1450
]
],
[
[
22,
63,
461
],
[
461,
24,
1450
]
],
[
[
22,
24,
659
],
[
659,
63,
1450
]
],
[
[
22,
24,
1592
],
[
1592,
24... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
... | Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol ... |
DB00087 | DB00290 | 599 | 329 | [
"DDInter41",
"DDInter219"
] | Alemtuzumab | Bleomycin | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Moderate | 1 | [
[
[
599,
24,
329
]
],
[
[
599,
24,
58
],
[
58,
24,
329
]
],
[
[
599,
24,
372
],
[
372,
63,
329
]
],
[
[
599,
63,
1253
],
[
1253,
24,... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bleomycin"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Bleomycin
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofar... |
DB00348 | DB15093 | 254 | 1,654 | [
"DDInter1300",
"DDInter1698"
] | Nitisinone | Somapacitan | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
254,
24,
1654
]
],
[
[
254,
63,
10
],
[
10,
24,
1654
]
],
[
[
254,
24,
351
],
[
351,
24,
1654
]
],
[
[
254,
63,
1101
],
[
1101,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapsone"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib ... |
DB09498 | DB12674 | 810 | 975 | [
"DDInter1715",
"DDInter1105"
] | Strontium chloride Sr-89 | Lurbinectedin | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
810,
24,
975
]
],
[
[
810,
63,
1488
],
[
1488,
24,
975
]
],
[
[
810,
24,
738
],
[
738,
24,
975
]
],
[
[
810,
24,
351
],
[
351,
2... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when... |
DB00014 | DB01064 | 521 | 1,148 | [
"DDInter839",
"DDInter987"
] | Goserelin | Isoprenaline | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
521,
24,
1148
]
],
[
[
521,
24,
480
],
[
480,
24,
1148
]
],
[
[
521,
21,
29316
],
[
29316,
60,
1148
]
],
[
[
521,
24,
1151
],
[
1151,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Goserelin (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Isoprenaline (Compou... |
DB00556 | DB06663 | 1,262 | 1,154 | [
"DDInter1429",
"DDInter1398"
] | Perflutren | Pasireotide | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1262,
25,
1154
]
],
[
[
1262,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1262,
23,
112
],
[
112,
23,
1154
]
],
[
[
1262,
24,
1662
],
[
16... | [
[
[
"Perflutren",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Perflutren",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused b... | Perflutren (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken... |
DB00317 | DB01118 | 883 | 33 | [
"DDInter810",
"DDInter76"
] | Gefitinib | Amiodarone | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
883,
24,
33
]
],
[
[
883,
24,
540
],
[
540,
1,
33
]
],
[
[
883,
6,
9842
],
[
9842,
45,
33
]
],
[
[
883,
7,
9242
],
[
9242,
46,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Gefitinib (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Amiodarone (Compound)
Gefitinib (Compound) upregulates WDR7 (Gene) and WDR7 (Gene) is up... |
DB00388 | DB01159 | 1,636 | 419 | [
"DDInter1453",
"DDInter854"
] | Phenylephrine | Halothane | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Major | 2 | [
[
[
1636,
25,
419
]
],
[
[
1636,
24,
1148
],
[
1148,
24,
419
]
],
[
[
1636,
25,
1264
],
[
1264,
24,
419
]
],
[
[
1636,
24,
659
],
[
659,
... | [
[
[
"Phenylephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halothane"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
"Iso... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Halothane
Phenylephrine may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cau... |
DB00981 | DB09128 | 1,528 | 1,241 | [
"DDInter1462",
"DDInter231"
] | Physostigmine | Brexpiprazole | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
1528,
24,
1241
]
],
[
[
1528,
63,
543
],
[
543,
24,
1241
]
],
[
[
1528,
24,
1662
],
[
1662,
63,
1241
]
],
[
[
1528,
24,
1264
],
[
1264... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
],... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric... |
DB06335 | DB11730 | 761 | 351 | [
"DDInter1646",
"DDInter1588"
] | Saxagliptin | Ribociclib | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
761,
24,
351
]
],
[
[
761,
63,
222
],
[
222,
23,
351
]
],
[
[
761,
24,
283
],
[
283,
62,
351
]
],
[
[
761,
63,
288
],
[
288,
24,... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[... | Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedr... |
DB01259 | DB12332 | 392 | 1,619 | [
"DDInter1024",
"DDInter1626"
] | Lapatinib | Rucaparib | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
392,
24,
1619
]
],
[
[
392,
63,
222
],
[
222,
23,
1619
]
],
[
[
392,
23,
271
],
[
271,
23,
1619
]
],
[
[
392,
62,
112
],
[
112,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Lapatinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.