drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00367 | DB08912 | 566 | 1,040 | [
"DDInter1061",
"DDInter462"
] | Levonorgestrel | Dabrafenib | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Major | 2 | [
[
[
566,
25,
1040
]
],
[
[
566,
6,
8374
],
[
8374,
45,
1040
]
],
[
[
566,
7,
13128
],
[
13128,
46,
1040
]
],
[
[
566,
18,
2097
],
[
2097,
... | [
[
[
"Levonorgestrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dabrafenib"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Levonorgestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound)
Levonorgestrel (Compound) upregulates NARFL (Gene) and NARFL (Gene) is upregulated by Dabrafenib (Compound)
Levonorgestrel (Compound) downregulates ERBB2 (Gene) and ERBB2 (Gene) is upregulated by Dabrafenib (Compound)
Levo... |
DB00686 | DB08896 | 383 | 292 | [
"DDInter1424",
"DDInter1576"
] | Pentosan polysulfate | Regorafenib | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
383,
24,
292
]
],
[
[
383,
21,
28658
],
[
28658,
60,
292
]
],
[
[
383,
24,
765
],
[
765,
24,
292
]
],
[
[
383,
63,
553
],
[
553,
... | [
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Pentosan polysulfate",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (S... | Pentosan polysulfate (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Regorafenib (Compound)
Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00420 | DB06704 | 508 | 247 | [
"DDInter1532",
"DDInter951"
] | Promazine | Iobenguane (I-123) | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
508,
24,
247
]
],
[
[
508,
1,
820
],
[
820,
24,
247
]
],
[
[
508,
40,
1178
],
[
1178,
24,
247
]
],
[
[
508,
25,
497
],
[
497,
25... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Promazine",
"{u} (Compound) resembles {v} (Compound)",
"Alimemazine"
],
[
"Alimemazine",
"{u} may cause a moderat... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Promazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Promazine (Compound) resembles Trifluoperazine (Compound) ... |
DB00001 | DB00472 | 1,578 | 758 | [
"DDInter1037",
"DDInter758"
] | Lepirudin | Fluoxetine | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
1578,
24,
758
]
],
[
[
1578,
24,
109
],
[
109,
40,
758
]
],
[
[
1578,
25,
20
],
[
20,
24,
758
]
],
[
[
1578,
25,
802
],
[
802,
6... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
[
... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compound)
Lepirudin may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a moderate interaction that could exacerbate d... |
DB00471 | DB12887 | 201 | 1,598 | [
"DDInter1242",
"DDInter1750"
] | Montelukast | Tazemetostat | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
201,
24,
1598
]
],
[
[
201,
24,
888
],
[
888,
24,
1598
]
],
[
[
201,
63,
1324
],
[
1324,
24,
1598
]
],
[
[
201,
24,
982
],
[
982,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[... | Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Tr... |
DB00444 | DB15982 | 63 | 1,339 | [
"DDInter1765",
"DDInter193"
] | Teniposide | Berotralstat | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
63,
24,
1339
]
],
[
[
63,
24,
283
],
[
283,
23,
1339
]
],
[
[
63,
24,
1213
],
[
1213,
24,
1339
]
],
[
[
63,
63,
134
],
[
134,
24... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatin... |
DB00662 | DB04844 | 717 | 843 | [
"DDInter1873",
"DDInter1778"
] | Trimethobenzamide | Tetrabenazine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
717,
24,
843
]
],
[
[
717,
21,
28793
],
[
28793,
60,
843
]
],
[
[
717,
24,
649
],
[
649,
24,
843
]
],
[
[
717,
63,
1594
],
[
1594,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Trimethobenzamide",
"{u} (Compound) causes {v} (Side Effect)",
"Blood disorder"
],
[
"Blood disorder",
... | Trimethobenzamide (Compound) causes Blood disorder (Side Effect) and Blood disorder (Side Effect) is caused by Tetrabenazine (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate disea... |
DB08932 | DB14568 | 1,398 | 982 | [
"DDInter1111",
"DDInter1000"
] | Macitentan | Ivosidenib | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
1398,
24,
982
]
],
[
[
1398,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1398,
63,
1478
],
[
1478,
24,
982
]
],
[
[
1398,
24,
159
],
[
159,
... | [
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor... |
DB00468 | DB06788 | 1,424 | 1,616 | [
"DDInter1557",
"DDInter864"
] | Quinine | Histrelin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
1424,
24,
1616
]
],
[
[
1424,
23,
112
],
[
112,
23,
1616
]
],
[
[
1424,
24,
1664
],
[
1664,
24,
1616
]
],
[
[
1424,
63,
1179
],
[
1179... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Quinine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"M... | Quinine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidon... |
DB06616 | DB08938 | 594 | 1,384 | [
"DDInter224",
"DDInter1112"
] | Bosutinib | Magaldrate | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
594,
24,
1384
]
],
[
[
594,
64,
684
],
[
684,
23,
1384
]
],
[
[
594,
63,
752
],
[
752,
23,
1384
]
],
[
[
594,
24,
1468
],
[
1468,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thioridazi... | Bosutinib may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause ... |
DB00564 | DB08899 | 1,236 | 129 | [
"DDInter293",
"DDInter649"
] | Carbamazepine | Enzalutamide | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1236,
24,
129
]
],
[
[
1236,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1236,
54,
19196
],
[
19196,
15,
129
]
],
[
[
1236,
21,
28703
],
[
287... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Carbamazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Carbamazepine (Compound) is included by Cytochrome P450 3A4 Inducers (Pharmacologic Class) and Cytochrome P450 3A4 Inducers (Pharmacologic Class) includes Enzalutamide (Compound)
Carbamazepine (Compound) causes Pruritus (... |
DB11581 | DB11978 | 1,456 | 124 | [
"DDInter1926",
"DDInter822"
] | Venetoclax | Glasdegib | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1456,
25,
124
]
],
[
[
1456,
62,
1135
],
[
1135,
23,
124
]
],
[
[
1456,
24,
466
],
[
466,
62,
124
]
],
[
[
1456,
24,
327
],
[
327,
... | [
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Venetoclax",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Venetoclax may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamid... |
DB01263 | DB08880 | 859 | 1,510 | [
"DDInter1494",
"DDInter1771"
] | Posaconazole | Teriflunomide | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
859,
25,
1510
]
],
[
[
859,
63,
608
],
[
608,
23,
1510
]
],
[
[
859,
24,
129
],
[
129,
63,
1510
]
],
[
[
859,
25,
1406
],
[
1406,
... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lido... | Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and E... |
DB01110 | DB08827 | 86 | 990 | [
"DDInter1209",
"DDInter1085"
] | Miconazole | Lomitapide | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Moderate | 1 | [
[
[
86,
24,
990
]
],
[
[
86,
63,
1080
],
[
1080,
1,
990
]
],
[
[
86,
6,
8374
],
[
8374,
45,
990
]
],
[
[
86,
21,
28701
],
[
28701,
6... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomitapide"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Miconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Miconazole (Compound) causes Discomfort (Side Effect) and Discomfo... |
DB00559 | DB00877 | 152 | 629 | [
"DDInter223",
"DDInter1678"
] | Bosentan | Sirolimus | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
152,
24,
629
]
],
[
[
152,
6,
8374
],
[
8374,
45,
629
]
],
[
[
152,
21,
28898
],
[
28898,
60,
629
]
],
[
[
152,
25,
1476
],
[
1476,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Bosentan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Bosentan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sirolimus (Compound)
Bosentan (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Sirolimus (Compound)
Bosentan may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause ... |
DB00475 | DB01176 | 1,119 | 537 | [
"DDInter355",
"DDInter453"
] | Chlordiazepoxide | Cyclizine | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1119,
24,
537
]
],
[
[
1119,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1119,
24,
104
],
[
104,
1,
537
]
],
[
[
1119,
1,
695
],
[
695,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazi... |
DB00443 | DB00951 | 251 | 1,072 | [
"DDInter195",
"DDInter986"
] | Betamethasone | Isoniazid | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Minor | 0 | [
[
[
251,
23,
1072
]
],
[
[
251,
6,
8374
],
[
8374,
45,
1072
]
],
[
[
251,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
251,
1,
1486
],
[
1486,
... | [
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Isoniazid"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Isoniazid (Compound)
Betamethasone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Betamethasone (Compound) resembles Methylprednisolone (Compound) and Methylprednisolone may cause a minor intera... |
DB00816 | DB01087 | 1,674 | 1,520 | [
"DDInter1346",
"DDInter1520"
] | Orciprenaline | Primaquine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
1674,
24,
1520
]
],
[
[
1674,
24,
1487
],
[
1487,
64,
1520
]
],
[
[
1674,
21,
28722
],
[
28722,
60,
1520
]
],
[
[
1674,
63,
508
],
[
5... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Orciprenaline (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Primaquine (Compo... |
DB00023 | DB01263 | 305 | 859 | [
"DDInter127",
"DDInter1494"
] | Asparaginase Escherichia coli | Posaconazole | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
305,
24,
859
]
],
[
[
305,
25,
1101
],
[
1101,
23,
859
]
],
[
[
305,
24,
482
],
[
482,
24,
859
]
],
[
[
305,
24,
850
],
[
850,
6... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Be... | Asparaginase Escherichia coli may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Posaconazole
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00060 | DB00382 | 912 | 62 | [
"DDInter947",
"DDInter1734"
] | Interferon beta-1a | Tacrine | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Moderate | 1 | [
[
[
912,
24,
62
]
],
[
[
912,
24,
848
],
[
848,
62,
62
]
],
[
[
912,
24,
79
],
[
79,
63,
62
]
],
[
[
912,
24,
482
],
[
482,
24,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tacrine"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Tacrine
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib an... |
DB00357 | DB08899 | 1,051 | 129 | [
"DDInter71",
"DDInter649"
] | Aminoglutethimide | Enzalutamide | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1051,
24,
129
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1051,
21,
28703
],
[
28703,
60,
129
]
],
[
[
1051,
23,
271
],
[
271,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by ... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Aminoglutethimide (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken wit... |
DB01087 | DB01177 | 1,520 | 77 | [
"DDInter1520",
"DDInter904"
] | Primaquine | Idarubicin | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1520,
24,
77
]
],
[
[
1520,
6,
12523
],
[
12523,
45,
77
]
],
[
[
1520,
21,
28852
],
[
28852,
60,
77
]
],
[
[
1520,
63,
739
],
[
739,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Primaquine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Primaquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Primaquine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Idarubicin (Compound)
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and ... |
DB00252 | DB00361 | 362 | 134 | [
"DDInter1460",
"DDInter1939"
] | Phenytoin | Vinorelbine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Moderate | 1 | [
[
[
362,
24,
134
]
],
[
[
362,
24,
147
],
[
147,
63,
134
]
],
[
[
362,
6,
4973
],
[
4973,
45,
134
]
],
[
[
362,
7,
6858
],
[
6858,
4... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
[
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Phenytoin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Vinorelbine (Compound)
Phenytoin (Compoun... |
DB09046 | DB12141 | 1,094 | 971 | [
"DDInter1201",
"DDInter817"
] | Metreleptin | Gilteritinib | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1094,
24,
971
]
],
[
[
1094,
24,
1135
],
[
1135,
23,
971
]
],
[
[
1094,
24,
466
],
[
466,
62,
971
]
],
[
[
1094,
63,
629
],
[
629,
... | [
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[... | Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Daro... |
DB00990 | DB14575 | 1,547 | 733 | [
"DDInter705",
"DDInter674"
] | Exemestane | Eslicarbazepine | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
1547,
24,
733
]
],
[
[
1547,
63,
1101
],
[
1101,
23,
733
]
],
[
[
1547,
24,
129
],
[
129,
24,
733
]
],
[
[
1547,
24,
1476
],
[
1476,
... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and E... |
DB01224 | DB01611 | 623 | 1,487 | [
"DDInter1553",
"DDInter893"
] | Quetiapine | Hydroxychloroquine | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
623,
25,
1487
]
],
[
[
623,
63,
1520
],
[
1520,
25,
1487
]
],
[
[
623,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
623,
21,
28658
],
[
2865... | [
[
[
"Quetiapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"Pr... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Quetiapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Quetiapine (Compo... |
DB00215 | DB12364 | 1,230 | 1,421 | [
"DDInter388",
"DDInter200"
] | Citalopram | Betrixaban | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
1230,
24,
1421
]
],
[
[
1230,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
1230,
25,
1151
],
[
1151,
24,
1421
]
],
[
[
1230,
23,
760
],
[
760... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Citalopram may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a ... |
DB12267 | DB12674 | 1,476 | 975 | [
"DDInter233",
"DDInter1105"
] | Brigatinib | Lurbinectedin | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1476,
24,
975
]
],
[
[
1476,
24,
159
],
[
159,
63,
975
]
],
[
[
1476,
63,
372
],
[
372,
24,
975
]
],
[
[
1476,
64,
1101
],
[
1101,
... | [
[
[
"Brigatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Brigatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine ... |
DB00802 | DB11817 | 1,322 | 1,259 | [
"DDInter43",
"DDInter165"
] | Alfentanil | Baricitinib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
1322,
24,
1259
]
],
[
[
1322,
24,
927
],
[
927,
24,
1259
]
],
[
[
1322,
40,
411
],
[
411,
24,
1259
]
],
[
[
1322,
63,
475
],
[
475,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Alfentanil (Compound) resembles Remifentanil (Compound) and Remifentanil may cause a moderate interaction tha... |
DB00701 | DB00969 | 1,091 | 2 | [
"DDInter90",
"DDInter52"
] | Amprenavir | Alosetron | Amprenavir is a protease inhibitor used to treat HIV infection. | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | Moderate | 1 | [
[
[
1091,
24,
2
]
],
[
[
1091,
6,
6017
],
[
6017,
45,
2
]
],
[
[
1091,
21,
28883
],
[
28883,
60,
2
]
],
[
[
1091,
25,
1362
],
[
1362,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alosetron"
]
],
[
[
"Amprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Amprenavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Alosetron (Compound)
Amprenavir (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Alosetron (Compound)
Amprenavir may lead to a major life threatening interaction when taken with Olaparib and Olaparib may ca... |
DB00197 | DB00396 | 1,324 | 989 | [
"DDInter1881",
"DDInter1529"
] | Troglitazone | Progesterone | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss . Progesterone is used in va... | Moderate | 1 | [
[
[
1324,
24,
989
]
],
[
[
1324,
24,
891
],
[
891,
40,
989
]
],
[
[
1324,
24,
167
],
[
167,
1,
989
]
],
[
[
1324,
24,
868
],
[
868,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone (Compound) resembles Progesterone (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Prog... |
DB00843 | DB01142 | 479 | 1,264 | [
"DDInter583",
"DDInter593"
] | Donepezil | Doxepin | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
479,
24,
1264
]
],
[
[
479,
24,
401
],
[
401,
24,
1264
]
],
[
[
479,
63,
832
],
[
832,
24,
1264
]
],
[
[
479,
6,
4228
],
[
4228,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tri... |
DB00069 | DB09268 | 367 | 1,662 | [
"DDInter946",
"DDInter1464"
] | Interferon alfacon-1 | Picosulfuric acid | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
367,
24,
1662
]
],
[
[
367,
24,
595
],
[
595,
24,
1662
]
],
[
[
367,
63,
912
],
[
912,
24,
1662
]
],
[
[
367,
25,
534
],
[
534,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide and Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when tak... |
DB00372 | DB00700 | 999 | 312 | [
"DDInter1793",
"DDInter656"
] | Thiethylperazine | Eplerenone | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Moderate | 1 | [
[
[
999,
24,
312
]
],
[
[
999,
24,
443
],
[
443,
1,
312
]
],
[
[
999,
24,
849
],
[
849,
63,
312
]
],
[
[
999,
24,
1614
],
[
1614,
24... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone (Compound) resembles Eplerenone (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate in... |
DB00238 | DB11837 | 188 | 1,297 | [
"DDInter1285",
"DDInter1351"
] | Nevirapine | Osilodrostat | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
188,
24,
1297
]
],
[
[
188,
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1135
],
[
1135,
23,
1297
]
],
[
[
188,
24,
466
],
[
466,
62,
1297
]
],
[
[
188,
24,
1320
],
[
1320,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolu... |
DB01227 | DB11817 | 1,301 | 1,259 | [
"DDInter1043",
"DDInter165"
] | Levacetylmethadol | Baricitinib | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
1301,
24,
1259
]
],
[
[
1301,
25,
927
],
[
927,
24,
1259
]
],
[
[
1301,
24,
407
],
[
407,
24,
1259
]
],
[
[
1301,
40,
576
],
[
576,
... | [
[
[
"Levacetylmethadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
... | Levacetylmethadol may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may... |
DB00319 | DB00512 | 790 | 91 | [
"DDInter1474",
"DDInter1916"
] | Piperacillin | Vancomycin | Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Major | 2 | [
[
[
790,
25,
91
]
],
[
[
790,
6,
10612
],
[
10612,
45,
91
]
],
[
[
790,
21,
28810
],
[
28810,
60,
91
]
],
[
[
790,
25,
663
],
[
663,
... | [
[
[
"Piperacillin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vancomycin"
]
],
[
[
"Piperacillin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compound)",
"V... | Piperacillin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Vancomycin (Compound)
Piperacillin (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Vancomycin (Compound)
Piperacillin may lead to a major life threatening interaction when taken with Me... |
DB00047 | DB08882 | 176 | 1,281 | [
"DDInter932",
"DDInter1070"
] | Insulin glargine | Linagliptin | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
176,
24,
1281
]
],
[
[
176,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
176,
23,
1103
],
[
1103,
23,
1281
]
],
[
[
176,
24,
1060
],
[
1060,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction th... |
DB00687 | DB00814 | 870 | 1,171 | [
"DDInter747",
"DDInter1143"
] | Fludrocortisone | Meloxicam | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Moderate | 1 | [
[
[
870,
24,
1171
]
],
[
[
870,
63,
1027
],
[
1027,
40,
1171
]
],
[
[
870,
21,
28748
],
[
28748,
60,
1171
]
],
[
[
870,
24,
473
],
[
473,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
],
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Fludrocortisone (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Meloxicam (Compound)
Fludrocortisone may cause a moderate inter... |
DB00285 | DB00581 | 1,100 | 355 | [
"DDInter1927",
"DDInter1018"
] | Venlafaxine | Lactulose | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
1100,
24,
355
]
],
[
[
1100,
21,
29180
],
[
29180,
60,
355
]
],
[
[
1100,
24,
286
],
[
286,
62,
355
]
],
[
[
1100,
24,
79
],
[
79,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Venlafaxine",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal distension"
],
[
"Abdominal distension",
"{u... | Venlafaxine (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Lactulose (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit c... |
DB00780 | DB00902 | 551 | 104 | [
"DDInter1440",
"DDInter1168"
] | Phenelzine | Methdilazine | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
551,
24,
104
]
],
[
[
551,
63,
13
],
[
13,
24,
104
]
],
[
[
551,
24,
820
],
[
820,
1,
104
]
],
[
[
551,
24,
537
],
[
537,
40,
... | [
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB00365 | DB14723 | 839 | 159 | [
"DDInter842",
"DDInter1026"
] | Grepafloxacin | Larotrectinib | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
839,
24,
159
]
],
[
[
839,
23,
222
],
[
222,
23,
159
]
],
[
[
839,
23,
63
],
[
63,
24,
159
]
],
[
[
839,
24,
951
],
[
951,
24,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Teniposide and T... |
DB01165 | DB09080 | 1,539 | 144 | [
"DDInter1325",
"DDInter1331"
] | Ofloxacin | Olodaterol | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1539,
24,
144
]
],
[
[
1539,
1,
956
],
[
956,
24,
144
]
],
[
[
1539,
25,
1011
],
[
1011,
24,
144
]
],
[
[
1539,
64,
11
],
[
11,
... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Ofloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Norfloxacin"
],
[
"Norfloxacin",
"{u} may cause a moderat... | Ofloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Ofloxacin may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate dis... |
DB01175 | DB06691 | 318 | 849 | [
"DDInter672",
"DDInter1155"
] | Escitalopram | Mepyramine | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
318,
24,
849
]
],
[
[
318,
63,
1594
],
[
1594,
24,
849
]
],
[
[
318,
6,
12523
],
[
12523,
45,
849
]
],
[
[
318,
24,
407
],
[
407,
... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Escitalopram (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Escitalopram m... |
DB01227 | DB09074 | 1,301 | 1,362 | [
"DDInter1043",
"DDInter1327"
] | Levacetylmethadol | Olaparib | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1301,
24,
1362
]
],
[
[
1301,
40,
576
],
[
576,
24,
1362
]
],
[
[
1301,
64,
353
],
[
353,
24,
1362
]
],
[
[
1301,
25,
1619
],
[
1619,
... | [
[
[
"Levacetylmethadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Levacetylmethadol",
"{u} (Compound) resembles {v} (Compound)",
"Methadone"
],
[
"Methadone",
"{u} may cause... | Levacetylmethadol (Compound) resembles Methadone (Compound) and Methadone may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Levacetylmethadol may lead to a major life threatening interaction when taken with Griseofulvin and Griseofulvin may cause a moderate interaction that could ... |
DB01234 | DB06290 | 1,220 | 1,449 | [
"DDInter513",
"DDInter1673"
] | Dexamethasone | Simeprevir | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Major | 2 | [
[
[
1220,
25,
1449
]
],
[
[
1220,
6,
4973
],
[
4973,
45,
1449
]
],
[
[
1220,
21,
29093
],
[
29093,
60,
1449
]
],
[
[
1220,
25,
466
],
[
46... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Simeprevir"
]
],
[
[
"Dexamethasone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Sim... | Dexamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Simeprevir (Compound)
Dexamethasone (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Simeprevir (Compound)
Dexamethasone may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide m... |
DB00889 | DB01591 | 1,133 | 667 | [
"DDInter840",
"DDInter1696"
] | Granisetron | Solifenacin | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
1133,
24,
667
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
667
]
],
[
[
1133,
21,
28743
],
[
28743,
60,
667
]
],
[
[
1133,
23,
112
],
[
112,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Solifenacin (Compound)
Granisetron (Compound) causes Atrial fibrillation (Side Effect) and Atrial fibrillation (Side Effect) is caused by Solifenacin (Compound)
Granisetron may cause a minor interaction that can limit clinical effects when taken w... |
DB09570 | DB11979 | 1,480 | 1,320 | [
"DDInter1002",
"DDInter625"
] | Ixazomib | Elagolix | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1480,
24,
1320
]
],
[
[
1480,
63,
168
],
[
168,
23,
1320
]
],
[
[
1480,
63,
1249
],
[
1249,
24,
1320
]
],
[
[
1480,
64,
129
],
[
129,
... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"B... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin may c... |
DB00030 | DB01037 | 1,685 | 1,161 | [
"DDInter934",
"DDInter1653"
] | Insulin human | Selegiline | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Moderate | 1 | [
[
[
1685,
24,
1161
]
],
[
[
1685,
24,
551
],
[
551,
1,
1161
]
],
[
[
1685,
24,
1411
],
[
1411,
63,
1161
]
],
[
[
1685,
24,
245
],
[
245,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Selegiline (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction th... |
DB08816 | DB08899 | 578 | 129 | [
"DDInter1802",
"DDInter649"
] | Ticagrelor | Enzalutamide | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
578,
25,
129
]
],
[
[
578,
6,
8374
],
[
8374,
45,
129
]
],
[
[
578,
21,
28703
],
[
28703,
60,
129
]
],
[
[
578,
23,
271
],
[
271,
... | [
[
[
"Ticagrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Ticagrelor",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Enzal... | Ticagrelor (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Ticagrelor (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mira... |
DB00703 | DB01088 | 997 | 714 | [
"DDInter1167",
"DDInter908"
] | Methazolamide | Iloprost | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
997,
24,
714
]
],
[
[
997,
25,
1479
],
[
1479,
24,
714
]
],
[
[
997,
63,
1648
],
[
1648,
24,
714
]
],
[
[
997,
24,
1450
],
[
1450,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Methazolamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetylsalicylic acid"
],
[
... | Methazolamide may lead to a major life threatening interaction when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin ... |
DB00317 | DB01110 | 883 | 86 | [
"DDInter810",
"DDInter1209"
] | Gefitinib | Miconazole | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
883,
24,
86
]
],
[
[
883,
6,
10215
],
[
10215,
45,
86
]
],
[
[
883,
7,
2067
],
[
2067,
46,
86
]
],
[
[
883,
18,
2183
],
[
2183,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Gefitinib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",... | Gefitinib (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Miconazole (Compound)
Gefitinib (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Miconazole (Compound)
Gefitinib (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Miconazole (Compound)
Gefitinib (Comp... |
DB00108 | DB14730 | 1,066 | 1,412 | [
"DDInter1268",
"DDInter264"
] | Natalizumab | Calaspargase pegol | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1066,
24,
1412
]
],
[
[
1066,
25,
250
],
[
250,
24,
1412
]
],
[
[
1066,
64,
268
],
[
268,
24,
1412
]
],
[
[
1066,
24,
267
],
[
267,
... | [
[
[
"Natalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Blinatumomab"
],
[
... | Natalizumab may lead to a major life threatening interaction when taken with Blinatumomab and Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Natalizumab may lead to a major life threatening interaction when taken with Peginterferon alfa-2b and Peginterfer... |
DB01059 | DB08907 | 956 | 1,344 | [
"DDInter1313",
"DDInter280"
] | Norfloxacin | Canagliflozin | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
956,
24,
1344
]
],
[
[
956,
24,
549
],
[
549,
1,
1344
]
],
[
[
956,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
956,
21,
28873
],
[
28873,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Norfloxacin (Compound) causes Pancreatitis (Side Eff... |
DB00662 | DB00980 | 717 | 969 | [
"DDInter1873",
"DDInter1564"
] | Trimethobenzamide | Ramelteon | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Moderate | 1 | [
[
[
717,
24,
969
]
],
[
[
717,
21,
28921
],
[
28921,
60,
969
]
],
[
[
717,
24,
100
],
[
100,
24,
969
]
],
[
[
717,
63,
1242
],
[
1242,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
]
],
[
[
"Trimethobenzamide",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Ef... | Trimethobenzamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Ramelteon (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases ... |
DB00774 | DB00902 | 1,577 | 104 | [
"DDInter889",
"DDInter1168"
] | Hydroflumethiazide | Methdilazine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1577,
24,
104
]
],
[
[
1577,
24,
820
],
[
820,
1,
104
]
],
[
[
1577,
24,
401
],
[
401,
63,
104
]
],
[
[
1577,
24,
286
],
[
286,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazi... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderat... |
DB00377 | DB06700 | 1,494 | 643 | [
"DDInter1382",
"DDInter511"
] | Palonosetron | Desvenlafaxine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Major | 2 | [
[
[
1494,
25,
643
]
],
[
[
1494,
64,
1100
],
[
1100,
1,
643
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
643
]
],
[
[
1494,
21,
28641
],
[
28641,... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venlafaxine"
],
[
"Venlafaxine",
... | Palonosetron may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Desvenlafaxine (Compound)
Palonosetron (Compound) causes Hot flush (Side Effect) and Hot flus... |
DB00641 | DB00661 | 467 | 122 | [
"DDInter1675",
"DDInter1928"
] | Simvastatin | Verapamil | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Major | 2 | [
[
[
467,
25,
122
]
],
[
[
467,
6,
12523
],
[
12523,
45,
122
]
],
[
[
467,
7,
10770
],
[
10770,
45,
122
]
],
[
[
467,
7,
5727
],
[
5727,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Verapamil"
]
],
[
[
"Simvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Verapa... | Simvastatin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Verapamil (Compound)
Simvastatin (Compound) upregulates CACNB3 (Gene) and CACNB3 (Gene) is bound by Verapamil (Compound)
Simvastatin (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Verapamil (Compound)
Simvastatin (Compound) c... |
DB00092 | DB01076 | 58 | 700 | [
"DDInter40",
"DDInter133"
] | Alefacept | Atorvastatin | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
58,
24,
700
]
],
[
[
58,
24,
303
],
[
303,
23,
700
]
],
[
[
58,
24,
896
],
[
896,
24,
700
]
],
[
[
58,
24,
1491
],
[
1491,
63,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Medroxyprogesterone acetate... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects when taken with Atorvastatin
Alefacept may cause a moderate interaction that could exacerbate diseases when ... |
DB00304 | DB01261 | 1,657 | 170 | [
"DDInter508",
"DDInter1679"
] | Desogestrel | Sitagliptin | Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological activ... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1657,
24,
170
]
],
[
[
1657,
21,
28792
],
[
28792,
60,
170
]
],
[
[
1657,
24,
1254
],
[
1254,
63,
170
]
],
[
[
1657,
1,
1197
],
[
1197... | [
[
[
"Desogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Desogestrel",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorder... | Desogestrel (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Sitagliptin (Compound)
Desogestrel may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that ... |
DB06754 | DB09075 | 707 | 498 | [
"DDInter471",
"DDInter621"
] | Danaparoid | Edoxaban | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans. The active constituents are heparan, dermatan and, and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity tha... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
707,
25,
498
]
],
[
[
707,
23,
944
],
[
944,
62,
498
]
],
[
[
707,
24,
1004
],
[
1004,
63,
498
]
],
[
[
707,
24,
41
],
[
41,
24,... | [
[
[
"Danaparoid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Danaparoid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Danaparoid may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl ... |
DB01124 | DB01197 | 1,411 | 1,603 | [
"DDInter1828",
"DDInter292"
] | Tolbutamide | Captopril | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1411,
24,
1603
]
],
[
[
1411,
63,
610
],
[
610,
1,
1603
]
],
[
[
1411,
6,
10612
],
[
10612,
45,
1603
]
],
[
[
1411,
21,
28725
],
[
287... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Tolbutamide (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Captopril (Compound)
Tolbutamide (Compound) causes Pancytopenia (Side Effect) and Pancy... |
DB00307 | DB00520 | 1,101 | 1,358 | [
"DDInter202",
"DDInter306"
] | Bexarotene | Caspofungin | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of th... | Moderate | 1 | [
[
[
1101,
24,
1358
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
1358
]
],
[
[
1101,
21,
29173
],
[
29173,
60,
1358
]
],
[
[
1101,
24,
267
],
[
26... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caspofungin"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Caspofungin (Compound)
Bexarotene (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Caspofungin (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with N... |
DB00520 | DB09280 | 1,358 | 1,604 | [
"DDInter306",
"DDInter1101"
] | Caspofungin | Lumacaftor | Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of th... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
1358,
24,
1604
]
],
[
[
1358,
24,
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],
[
1017,
64,
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],
[
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],
[
868,
25,
1604
]
],
[
[
1358,
24,
1017
],
[
1017... | [
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Caspofungin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may lead to a major life threatening interaction when taken with Lumacaftor
Caspofungin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may le... |
DB01255 | DB01390 | 633 | 1,117 | [
"DDInter1078",
"DDInter1683"
] | Lisdexamfetamine | Sodium bicarbonate | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Moderate | 1 | [
[
[
633,
24,
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]
],
[
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633,
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[
29093,
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[
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633,
63,
1559
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[
1559,
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],
[
[
633,
40,
743
],
[
743,
... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Lisdexamfetamine",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side... | Lisdexamfetamine (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famotidine may cause a minor interaction that can limit clinical effects when take... |
DB01619 | DB14509 | 830 | 1,399 | [
"DDInter1441",
"DDInter1081"
] | Phenindamine | Lithium carbonate | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
830,
24,
1399
]
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[
[
830,
63,
506
],
[
506,
24,
1399
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[
[
830,
24,
407
],
[
407,
24,
1399
]
],
[
[
830,
1,
537
],
[
537,
2... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00060 | DB11730 | 912 | 351 | [
"DDInter947",
"DDInter1588"
] | Interferon beta-1a | Ribociclib | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
912,
24,
351
]
],
[
[
912,
24,
1247
],
[
1247,
23,
351
]
],
[
[
912,
24,
283
],
[
283,
62,
351
]
],
[
[
912,
24,
1561
],
[
1561,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethox... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01030 | DB14783 | 869 | 287 | [
"DDInter1835",
"DDInter574"
] | Topotecan | Diroximel fumarate | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
869,
24,
287
]
],
[
[
869,
63,
1101
],
[
1101,
24,
287
]
],
[
[
869,
24,
384
],
[
384,
24,
287
]
],
[
[
869,
64,
1555
],
[
1555,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and ... |
DB01309 | DB09068 | 1,254 | 1,427 | [
"DDInter933",
"DDInter1948"
] | Insulin glulisine | Vortioxetine | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1254,
24,
1427
]
],
[
[
1254,
63,
1220
],
[
1220,
24,
1427
]
],
[
[
1254,
24,
98
],
[
98,
63,
1427
]
],
[
[
1254,
63,
73
],
[
73,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethaso... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00496 | DB00981 | 194 | 1,528 | [
"DDInter480",
"DDInter1462"
] | Darifenacin | Physostigmine | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
194,
24,
1528
]
],
[
[
194,
21,
28658
],
[
28658,
60,
1528
]
],
[
[
194,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
194,
24,
543
],
[
543,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Darifenacin",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is c... | Darifenacin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Physostigmine (Compound)
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Ph... |
DB00443 | DB00999 | 251 | 504 | [
"DDInter195",
"DDInter883"
] | Betamethasone | Hydrochlorothiazide | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
251,
24,
504
]
],
[
[
251,
24,
1326
],
[
1326,
40,
504
]
],
[
[
251,
24,
178
],
[
178,
1,
504
]
],
[
[
251,
63,
323
],
[
323,
40... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamid... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembl... |
DB00661 | DB06292 | 122 | 549 | [
"DDInter1928",
"DDInter474"
] | Verapamil | Dapagliflozin | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
122,
24,
549
]
],
[
[
122,
24,
1344
],
[
1344,
40,
549
]
],
[
[
122,
6,
8374
],
[
8374,
45,
549
]
],
[
[
122,
21,
28898
],
[
28898,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Verapamil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Verapamil (Compound) causes Constipation (Side Effect) a... |
DB00945 | DB14730 | 1,479 | 1,412 | [
"DDInter20",
"DDInter264"
] | Acetylsalicylic acid | Calaspargase pegol | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1479,
24,
1412
]
],
[
[
1479,
25,
792
],
[
792,
24,
1412
]
],
[
[
1479,
63,
1347
],
[
1347,
24,
1412
]
],
[
[
1479,
64,
553
],
[
553,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Acetylsalicylic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
... | Acetylsalicylic acid may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Clopid... |
DB00099 | DB01169 | 440 | 57 | [
"DDInter735",
"DDInter120"
] | Filgrastim | Arsenic trioxide | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Moderate | 1 | [
[
[
440,
24,
57
]
],
[
[
440,
24,
384
],
[
384,
63,
57
]
],
[
[
440,
24,
770
],
[
770,
24,
57
]
],
[
[
440,
24,
1213
],
[
1213,
64,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and... |
DB00384 | DB01050 | 1,275 | 848 | [
"DDInter1859",
"DDInter900"
] | Triamterene | Ibuprofen | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1275,
24,
848
]
],
[
[
1275,
24,
1053
],
[
1053,
1,
848
]
],
[
[
1275,
7,
7720
],
[
7720,
45,
848
]
],
[
[
1275,
21,
28809
],
[
28809,... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
],
[... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Triamterene (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Ibuprofen (Compound)
Triamterene (Compound) causes Diarrhoea (Side Effect) and ... |
DB00745 | DB12001 | 307 | 564 | [
"DDInter1236",
"DDInter7"
] | Modafinil | Abemaciclib | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
307,
24,
564
]
],
[
[
307,
63,
1051
],
[
1051,
24,
564
]
],
[
[
307,
24,
868
],
[
868,
24,
564
]
],
[
[
307,
62,
600
],
[
600,
2... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
... | Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Vemurafe... |
DB01359 | DB06703 | 729 | 619 | [
"DDInter1417",
"DDInter793"
] | Penbutolol | Gadobutrol | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Gadobutrol is a second-generation extracellular non-ionic macrocyclic GBCA (gadolinium-based contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. Due to its physicochemical properties, gadobutrol is formulated at twice the gadolinium ion concentration compared to ot... | Moderate | 1 | [
[
[
729,
24,
619
]
],
[
[
729,
21,
28809
],
[
28809,
60,
619
]
],
[
[
729,
40,
461
],
[
461,
24,
619
]
],
[
[
729,
1,
668
],
[
668,
... | [
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadobutrol"
]
],
[
[
"Penbutolol",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caus... | Penbutolol (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Gadobutrol (Compound)
Penbutolol (Compound) resembles Timolol (Compound) and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Gadobutrol
Penbutolol (Compound) resembles Levobunolol (Compo... |
DB00834 | DB09054 | 932 | 384 | [
"DDInter1215",
"DDInter905"
] | Mifepristone | Idelalisib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
932,
25,
384
]
],
[
[
932,
25,
1618
],
[
1618,
24,
384
]
],
[
[
932,
64,
888
],
[
888,
24,
384
]
],
[
[
932,
24,
1468
],
[
1468,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabozantinib",
... | Mifepristone may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Mifepristone may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderat... |
DB00701 | DB11730 | 1,091 | 351 | [
"DDInter90",
"DDInter1588"
] | Amprenavir | Ribociclib | Amprenavir is a protease inhibitor used to treat HIV infection. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1091,
25,
351
]
],
[
[
1091,
23,
466
],
[
466,
62,
351
]
],
[
[
1091,
25,
112
],
[
112,
23,
351
]
],
[
[
1091,
23,
222
],
[
222,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Amprenavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
"Darolutami... | Amprenavir may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Amprenavir may lead to a major life threatening interaction when taken with Metronidazole and Metronidazole may ... |
DB00564 | DB00620 | 1,236 | 175 | [
"DDInter293",
"DDInter1855"
] | Carbamazepine | Triamcinolone | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
1236,
24,
175
]
],
[
[
1236,
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[
1573,
1,
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]
],
[
[
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63,
251
],
[
251,
1,
175
]
],
[
[
1236,
10,
11594
],
[
11594,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Triamci... |
DB00334 | DB09078 | 867 | 1,228 | [
"DDInter1326",
"DDInter1036"
] | Olanzapine | Lenvatinib | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
867,
24,
1228
]
],
[
[
867,
23,
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],
[
112,
23,
1228
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],
[
[
867,
24,
609
],
[
609,
24,
1228
]
],
[
[
867,
24,
927
],
[
927,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Olanzapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Olanzapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and ... |
DB00601 | DB06694 | 453 | 31 | [
"DDInter1073",
"DDInter1952"
] | Linezolid | Xylometazoline (nasal) | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Xylometazoline is an alkylbenzene. | Moderate | 1 | [
[
[
453,
24,
31
]
],
[
[
453,
24,
144
],
[
144,
63,
31
]
],
[
[
453,
24,
1148
],
[
1148,
24,
31
]
],
[
[
453,
25,
1629
],
[
1629,
63... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Xylometazoline"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
],
[
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Line... |
DB00398 | DB06414 | 79 | 655 | [
"DDInter1702",
"DDInter703"
] | Sorafenib | Etravirine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
79,
24,
655
]
],
[
[
79,
24,
786
],
[
786,
40,
655
]
],
[
[
79,
6,
4973
],
[
4973,
45,
655
]
],
[
[
79,
21,
28723
],
[
28723,
60... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Sorafenib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Etravirine (Compound)
Sorafenib (Compound) causes Malnutrition (Side Effect) and Malnutrit... |
DB00757 | DB08899 | 1,166 | 129 | [
"DDInter581",
"DDInter649"
] | Dolasetron | Enzalutamide | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1166,
25,
129
]
],
[
[
1166,
25,
918
],
[
918,
1,
129
]
],
[
[
1166,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1166,
21,
28703
],
[
28703,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
... | Dolasetron may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Dolasetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Dolasetron (Compound) causes Pruritus (Side Effect) and Pruritus (Side Ef... |
DB00307 | DB00882 | 1,101 | 596 | [
"DDInter202",
"DDInter409"
] | Bexarotene | Clomifene | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. | Major | 2 | [
[
[
1101,
25,
596
]
],
[
[
1101,
24,
888
],
[
888,
1,
596
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
596
]
],
[
[
1101,
21,
28845
],
[
28845,
... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomifene"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[
"Tamoxifen",
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen (Compound) resembles Clomifene (Compound)
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clomifene (Compound)
Bexarotene (Compound) causes Oedema (Side Effect) and Oedema (Side Eff... |
DB01166 | DB01259 | 477 | 392 | [
"DDInter379",
"DDInter1024"
] | Cilostazol | Lapatinib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
477,
24,
392
]
],
[
[
477,
6,
8374
],
[
8374,
45,
392
]
],
[
[
477,
7,
3727
],
[
3727,
46,
392
]
],
[
[
477,
21,
28688
],
[
28688,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Cilostazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Cilostazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Cilostazol (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Lapatinib (Compound)
Cilostazol (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Cilostazol ma... |
DB08908 | DB11627 | 713 | 1,367 | [
"DDInter564",
"DDInter860"
] | Dimethyl fumarate | Hepatitis B Vaccine (Recombinant) | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
713,
24,
1367
]
],
[
[
713,
63,
1083
],
[
1083,
24,
1367
]
],
[
[
713,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
713,
24,
1480
],
[
1480,
... | [
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Dimethyl fumarate may lead to a major life threatening interaction when taken ... |
DB00322 | DB08868 | 141 | 1,011 | [
"DDInter742",
"DDInter737"
] | Floxuridine | Fingolimod | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
141,
25,
1011
]
],
[
[
141,
21,
28714
],
[
28714,
60,
1011
]
],
[
[
141,
24,
748
],
[
748,
63,
1011
]
],
[
[
141,
24,
1136
],
[
1136,
... | [
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Floxuridine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused by {v} (Comp... | Floxuridine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Fingolimod (Compound)
Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB01218 | DB09268 | 1,493 | 1,662 | [
"DDInter852",
"DDInter1464"
] | Halofantrine | Picosulfuric acid | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Major | 2 | [
[
[
1493,
25,
1662
]
],
[
[
1493,
64,
1164
],
[
1164,
24,
1662
]
],
[
[
1493,
25,
484
],
[
484,
63,
1662
]
],
[
[
1493,
25,
1618
],
[
1618... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimipramine"
],
[
"Trimipramine... | Halofantrine may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Halofantrine may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may caus... |
DB00531 | DB10276 | 450 | 1,624 | [
"DDInter456",
"DDInter1623"
] | Cyclophosphamide | Rotavirus vaccine | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
450,
25,
1624
]
],
[
[
450,
63,
552
],
[
552,
25,
1624
]
],
[
[
450,
24,
1307
],
[
1307,
25,
1624
]
],
[
[
450,
25,
770
],
[
770,
... | [
[
[
"Cyclophosphamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
],
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may lead to a major life threatening interaction when taken with Rotavirus vaccine
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Mel... |
DB00501 | DB00745 | 752 | 307 | [
"DDInter380",
"DDInter1236"
] | Cimetidine | Modafinil | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Minor | 0 | [
[
[
752,
23,
307
]
],
[
[
752,
24,
704
],
[
704,
40,
307
]
],
[
[
752,
25,
1301
],
[
1301,
40,
307
]
],
[
[
752,
64,
362
],
[
362,
4... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
"... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Modafinil (Compound)
Cimetidine may lead to a major life threatening interaction when taken with Levacetylmethadol and Levacetylmethadol (Compound) resembles Modafinil (Compound)
Cimetid... |
DB00446 | DB06016 | 597 | 1,508 | [
"DDInter351",
"DDInter300"
] | Chloramphenicol | Cariprazine | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
597,
24,
1508
]
],
[
[
597,
24,
1593
],
[
1593,
63,
1508
]
],
[
[
597,
24,
1213
],
[
1213,
24,
1508
]
],
[
[
597,
63,
245
],
[
245,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib ... |
DB00877 | DB01067 | 629 | 959 | [
"DDInter1678",
"DDInter826"
] | Sirolimus | Glipizide | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
629,
24,
959
]
],
[
[
629,
63,
245
],
[
245,
40,
959
]
],
[
[
629,
24,
1411
],
[
1411,
1,
959
]
],
[
[
629,
6,
8374
],
[
8374,
4... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
... |
DB00398 | DB11915 | 79 | 1,293 | [
"DDInter1702",
"DDInter1909"
] | Sorafenib | Valbenazine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
79,
24,
1293
]
],
[
[
79,
23,
112
],
[
112,
23,
1293
]
],
[
[
79,
24,
710
],
[
710,
63,
1293
]
],
[
[
79,
63,
521
],
[
521,
24,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Sorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Sorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Bini... |
DB00414 | DB01579 | 590 | 341 | [
"DDInter16",
"DDInter1439"
] | Acetohexamide | Phendimetrazine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Moderate | 1 | [
[
[
590,
24,
341
]
],
[
[
590,
24,
1281
],
[
1281,
63,
341
]
],
[
[
590,
24,
401
],
[
401,
24,
341
]
],
[
[
590,
63,
1645
],
[
1645,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Phendimetrazine
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Prometha... |
DB01110 | DB11986 | 86 | 484 | [
"DDInter1209",
"DDInter648"
] | Miconazole | Entrectinib | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
86,
24,
484
]
],
[
[
86,
23,
271
],
[
271,
23,
484
]
],
[
[
86,
23,
466
],
[
466,
62,
484
]
],
[
[
86,
62,
222
],
[
222,
23,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Miconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Miconazole may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Miconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutam... |
DB00361 | DB11627 | 134 | 1,367 | [
"DDInter1939",
"DDInter860"
] | Vinorelbine | Hepatitis B Vaccine (Recombinant) | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
134,
24,
1367
]
],
[
[
134,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
134,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
134,
24,
1480
],
[
1480,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Al... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Vinorelbine may lead to a major life threatening interaction when taken with Cladribin... |
DB01168 | DB06691 | 1,053 | 849 | [
"DDInter1526",
"DDInter1155"
] | Procarbazine | Mepyramine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1053,
24,
849
]
],
[
[
1053,
64,
1594
],
[
1594,
24,
849
]
],
[
[
1053,
63,
272
],
[
272,
24,
849
]
],
[
[
1053,
24,
1190
],
[
1190,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxylamine"
],
[
"Doxyla... | Procarbazine may lead to a major life threatening interaction when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorphenir... |
DB00582 | DB01087 | 1,622 | 1,520 | [
"DDInter1946",
"DDInter1520"
] | Voriconazole | Primaquine | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
1622,
24,
1520
]
],
[
[
1622,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
1622,
6,
8374
],
[
8374,
45,
1520
]
],
[
[
1622,
21,
28722
],
[
28... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
... | Voriconazole may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Primaquine (Compound)
Voriconazole (Compound) caus... |
DB00261 | DB12332 | 702 | 1,619 | [
"DDInter93",
"DDInter1626"
] | Anagrelide | Rucaparib | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
702,
25,
1619
]
],
[
[
702,
24,
222
],
[
222,
23,
1619
]
],
[
[
702,
23,
112
],
[
112,
23,
1619
]
],
[
[
702,
24,
969
],
[
969,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramin... | Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
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