drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00374 | DB01115 | 1,061 | 336 | [
"DDInter1852",
"DDInter1291"
] | Treprostinil | Nifedipine | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
1061,
24,
336
]
],
[
[
1061,
63,
1428
],
[
1428,
1,
336
]
],
[
[
1061,
24,
1081
],
[
1081,
40,
336
]
],
[
[
1061,
24,
376
],
[
376,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nifedipine (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine (Comp... |
DB06335 | DB11952 | 761 | 800 | [
"DDInter1646",
"DDInter612"
] | Saxagliptin | Duvelisib | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
761,
24,
800
]
],
[
[
761,
63,
222
],
[
222,
23,
800
]
],
[
[
761,
24,
1476
],
[
1476,
63,
800
]
],
[
[
761,
63,
522
],
[
522,
2... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Briga... |
DB00434 | DB01200 | 13 | 469 | [
"DDInter459",
"DDInter243"
] | Cyproheptadine | Bromocriptine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
13,
24,
469
]
],
[
[
13,
6,
4228
],
[
4228,
45,
469
]
],
[
[
13,
18,
7669
],
[
7669,
46,
469
]
],
[
[
13,
7,
5998
],
[
5998,
46,... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) binds {v} (Gene)",
"HTR2A"
],
[
"HTR2A",
"{u} (Gene) is bound by {v} (Co... | Cyproheptadine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Bromocriptine (Compound)
Cyproheptadine (Compound) downregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Bromocriptine (Compound)
Cyproheptadine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Bromocriptine (Compoun... |
DB00495 | DB15091 | 139 | 676 | [
"DDInter1961",
"DDInter1901"
] | Zidovudine | Upadacitinib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
139,
25,
676
]
],
[
[
139,
24,
1430
],
[
1430,
24,
676
]
],
[
[
139,
63,
600
],
[
600,
24,
676
]
],
[
[
139,
23,
752
],
[
752,
2... | [
[
[
"Zidovudine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and... |
DB01087 | DB01169 | 1,520 | 57 | [
"DDInter1520",
"DDInter120"
] | Primaquine | Arsenic trioxide | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1520,
25,
57
]
],
[
[
1520,
6,
8374
],
[
8374,
45,
57
]
],
[
[
1520,
62,
1247
],
[
1247,
23,
57
]
],
[
[
1520,
24,
603
],
[
603,
... | [
[
[
"Primaquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Primaquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"A... | Primaquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxid... |
DB00270 | DB00374 | 1,428 | 1,061 | [
"DDInter993",
"DDInter1852"
] | Isradipine | Treprostinil | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Moderate | 1 | [
[
[
1428,
24,
1061
]
],
[
[
1428,
24,
885
],
[
885,
40,
1061
]
],
[
[
1428,
18,
1954
],
[
1954,
57,
1061
]
],
[
[
1428,
21,
28956
],
[
289... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]
],
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
... | Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Isradipine (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Treprostinil (Compound)
Isradipine (Compound) causes Palpitations (Sid... |
DB00668 | DB01242 | 874 | 1,237 | [
"DDInter652",
"DDInter410"
] | Epinephrine | Clomipramine | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Major | 2 | [
[
[
874,
25,
1237
]
],
[
[
874,
24,
684
],
[
684,
1,
1237
]
],
[
[
874,
25,
1164
],
[
1164,
1,
1237
]
],
[
[
874,
24,
146
],
[
146,
... | [
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomipramine"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
],
[
"Thio... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Epinephrine may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)
E... |
DB00333 | DB04837 | 576 | 649 | [
"DDInter1166",
"DDInter407"
] | Methadone | Clofedanol | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
576,
35,
649
]
],
[
[
576,
35,
1376
],
[
1376,
24,
649
]
],
[
[
576,
1,
675
],
[
675,
40,
649
]
],
[
[
576,
35,
832
],
[
832,
40... | [
[
[
"Methadone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Methadone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction t... | Methadone (Compound) resembles Clofedanol (Compound) and
Methadone (Compound) resembles Diphenhydramine (Compound) and Methadone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00030 | DB01320 | 1,685 | 651 | [
"DDInter934",
"DDInter783"
] | Insulin human | Fosphenytoin | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
1685,
24,
651
]
],
[
[
1685,
24,
362
],
[
362,
1,
651
]
],
[
[
1685,
24,
1479
],
[
1479,
23,
651
]
],
[
[
1685,
24,
5
],
[
5,
63... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor... |
DB00575 | DB00835 | 1,020 | 100 | [
"DDInter412",
"DDInter245"
] | Clonidine | Brompheniramine | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
1020,
24,
100
]
],
[
[
1020,
24,
832
],
[
832,
24,
100
]
],
[
[
1020,
63,
128
],
[
128,
24,
100
]
],
[
[
1020,
24,
649
],
[
649,
... | [
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
... | Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphe... |
DB06207 | DB09039 | 910 | 1,670 | [
"DDInter1667",
"DDInter629"
] | Silodosin | Eliglustat | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
910,
24,
1670
]
],
[
[
910,
63,
478
],
[
478,
24,
1670
]
],
[
[
910,
24,
124
],
[
124,
63,
1670
]
],
[
[
910,
24,
578
],
[
578,
... | [
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib m... |
DB00081 | DB10989 | 273 | 496 | [
"DDInter1838",
"DDInter858"
] | Tositumomab | Hepatitis A Vaccine | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
273,
24,
496
]
],
[
[
273,
25,
4
],
[
4,
24,
496
]
],
[
[
273,
24,
738
],
[
738,
63,
496
]
],
[
[
273,
24,
869
],
[
869,
24,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
... | Tositumomab may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken ... |
DB06228 | DB09054 | 792 | 384 | [
"DDInter1609",
"DDInter905"
] | Rivaroxaban | Idelalisib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
792,
24,
384
]
],
[
[
792,
63,
222
],
[
222,
23,
384
]
],
[
[
792,
24,
555
],
[
555,
23,
384
]
],
[
[
792,
62,
307
],
[
307,
23,... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Netupitant and Netu... |
DB00227 | DB01229 | 1,463 | 973 | [
"DDInter1098",
"DDInter1378"
] | Lovastatin | Paclitaxel (protein-bound) | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
1463,
24,
973
]
],
[
[
1463,
24,
310
],
[
310,
63,
973
]
],
[
[
1463,
6,
7524
],
[
7524,
45,
973
]
],
[
[
1463,
7,
2903
],
[
2903,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Lovastat... |
DB01069 | DB11640 | 401 | 1,267 | [
"DDInter1533",
"DDInter64"
] | Promethazine | Amifampridine | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
401,
24,
1267
]
],
[
[
401,
24,
407
],
[
407,
24,
1267
]
],
[
[
401,
63,
999
],
[
999,
24,
1267
]
],
[
[
401,
24,
913
],
[
913,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thi... |
DB12141 | DB12332 | 971 | 1,619 | [
"DDInter817",
"DDInter1626"
] | Gilteritinib | Rucaparib | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
971,
24,
1619
]
],
[
[
971,
63,
307
],
[
307,
23,
1619
]
],
[
[
971,
62,
112
],
[
112,
23,
1619
]
],
[
[
971,
63,
154
],
[
154,
... | [
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Gilteritinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB00095 | DB11703 | 66 | 405 | [
"DDInter623",
"DDInter9"
] | Efalizumab | Acalabrutinib | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
66,
24,
405
]
],
[
[
66,
24,
139
],
[
139,
24,
405
]
],
[
[
66,
63,
58
],
[
58,
24,
405
]
],
[
[
66,
24,
151
],
[
151,
63,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
],
[... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alef... |
DB00850 | DB06603 | 1,630 | 39 | [
"DDInter1432",
"DDInter1387"
] | Perphenazine | Panobinostat | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1630,
25,
39
]
],
[
[
1630,
23,
112
],
[
112,
23,
39
]
],
[
[
1630,
24,
272
],
[
272,
24,
39
]
],
[
[
1630,
63,
506
],
[
506,
24... | [
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Perphenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Perphenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniram... |
DB00241 | DB12941 | 288 | 466 | [
"DDInter257",
"DDInter481"
] | Butalbital | Darolutamide | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
288,
24,
466
]
],
[
[
288,
24,
351
],
[
351,
23,
466
]
],
[
[
288,
23,
752
],
[
752,
23,
466
]
],
[
[
288,
24,
159
],
[
159,
62,... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Butalbital may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidi... |
DB00377 | DB01128 | 1,494 | 918 | [
"DDInter1382",
"DDInter204"
] | Palonosetron | Bicalutamide | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
1494,
24,
918
]
],
[
[
1494,
24,
129
],
[
129,
40,
918
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
918
]
],
[
[
1494,
21,
28642
],
[
28642,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Palonosetron (Compound) causes Shock (Side Effect) and... |
DB01278 | DB02546 | 1,021 | 137 | [
"DDInter1506",
"DDInter1947"
] | Pramlintide | Vorinostat | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Moderate | 1 | [
[
[
1021,
24,
137
]
],
[
[
1021,
63,
1685
],
[
1685,
24,
137
]
],
[
[
1021,
24,
1296
],
[
1296,
63,
137
]
],
[
[
1021,
24,
1254
],
[
1254,... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorinostat"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin human"
],
... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Insulin deglu... |
DB00346 | DB11130 | 472 | 407 | [
"DDInter44",
"DDInter1344"
] | Alfuzosin | Opium | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
472,
24,
407
]
],
[
[
472,
1,
1433
],
[
1433,
24,
407
]
],
[
[
472,
24,
104
],
[
104,
24,
407
]
],
[
[
472,
63,
475
],
[
475,
24... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Alfuzosin",
"{u} (Compound) resembles {v} (Compound)",
"Doxazosin"
],
[
"Doxazosin",
"{u} may cause a moderate interac... | Alfuzosin (Compound) resembles Doxazosin (Compound) and Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Opium
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exac... |
DB04845 | DB14723 | 309 | 159 | [
"DDInter1001",
"DDInter1026"
] | Ixabepilone | Larotrectinib | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
309,
24,
159
]
],
[
[
309,
24,
1375
],
[
1375,
24,
159
]
],
[
[
309,
63,
63
],
[
63,
24,
159
]
],
[
[
309,
62,
307
],
[
307,
24,... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Ten... |
DB00397 | DB01362 | 1,466 | 497 | [
"DDInter1458",
"DDInter960"
] | Phenylpropanolamine | Iohexol | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1466,
25,
497
]
],
[
[
1466,
18,
7744
],
[
7744,
57,
497
]
],
[
[
1466,
21,
28681
],
[
28681,
60,
497
]
],
[
[
1466,
63,
999
],
[
999,... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) downregulates {v} (Gene)",
"PRR7"
],
[
"PRR7",
"{u} (Gene) is downregulated by {v} ... | Phenylpropanolamine (Compound) downregulates PRR7 (Gene) and PRR7 (Gene) is downregulated by Iohexol (Compound)
Phenylpropanolamine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Phenylpropanolamine may cause a moderate interaction that could exacerba... |
DB00448 | DB01166 | 1,215 | 477 | [
"DDInter1022",
"DDInter379"
] | Lansoprazole | Cilostazol | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
1215,
25,
477
]
],
[
[
1215,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1215,
21,
28919
],
[
28919,
60,
477
]
],
[
[
1215,
23,
801
],
[
801,
... | [
[
[
"Lansoprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Lansoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cil... | Lansoprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Lansoprazole (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Brivaracetam an... |
DB00087 | DB11730 | 599 | 351 | [
"DDInter41",
"DDInter1588"
] | Alemtuzumab | Ribociclib | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
599,
24,
351
]
],
[
[
599,
24,
310
],
[
310,
24,
351
]
],
[
[
599,
24,
987
],
[
987,
63,
351
]
],
[
[
599,
63,
1253
],
[
1253,
2... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae C... |
DB01142 | DB08865 | 1,264 | 1,593 | [
"DDInter593",
"DDInter448"
] | Doxepin | Crizotinib | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
1264,
25,
1593
]
],
[
[
1264,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1264,
7,
6952
],
[
6952,
46,
1593
]
],
[
[
1264,
21,
29093
],
[
290... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Doxepin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizotinib"
... | Doxepin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Doxepin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Crizotinib (Compound)
Doxepin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Doxepin may cause... |
DB01216 | DB01232 | 284 | 1,327 | [
"DDInter736",
"DDInter1640"
] | Finasteride | Saquinavir | Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting a... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
284,
24,
1327
]
],
[
[
284,
63,
798
],
[
798,
40,
1327
]
],
[
[
284,
6,
21998
],
[
21998,
45,
1327
]
],
[
[
284,
21,
28691
],
[
28691,... | [
[
[
"Finasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Finasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Finasteride may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Finasteride (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Saquinavir (Compound)
Finasteride (Compound) causes Somnolence (Side... |
DB09312 | DB14409 | 967 | 1,129 | [
"DDInter106",
"DDInter867"
] | Antithymocyte immunoglobulin (rabbit) | Human adenovirus e serotype 4 strain cl-68578 antigen | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin i... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
967,
24,
1129
]
],
[
[
967,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
967,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
967,
25,
1259
],
[
1259,
... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major lif... | Antilymphocyte immunoglobulin (horse) may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Antilymphocyte immunoglobulin (horse) may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderat... |
DB00262 | DB10315 | 552 | 1,137 | [
"DDInter302",
"DDInter1127"
] | Carmustine | Measles virus vaccine live attenuated | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
552,
25,
1137
]
],
[
[
552,
64,
581
],
[
581,
25,
1137
]
],
[
[
552,
24,
384
],
[
384,
25,
1137
]
],
[
[
552,
63,
1184
],
[
1184,
... | [
[
[
"Carmustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Carmustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Carmustine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB00026 | DB00495 | 1,184 | 139 | [
"DDInter94",
"DDInter1961"
] | Anakinra | Zidovudine | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Moderate | 1 | [
[
[
1184,
24,
139
]
],
[
[
1184,
24,
1083
],
[
1083,
24,
139
]
],
[
[
1184,
24,
309
],
[
309,
63,
139
]
],
[
[
1184,
63,
669
],
[
669,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabe... |
DB00860 | DB01041 | 891 | 770 | [
"DDInter1513",
"DDInter1789"
] | Prednisolone | Thalidomide | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
891,
25,
770
]
],
[
[
891,
5,
11555
],
[
11555,
44,
770
]
],
[
[
891,
7,
2900
],
[
2900,
46,
770
]
],
[
[
891,
18,
20113
],
[
20113,
... | [
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Prednisolone",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is trea... | Prednisolone (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compound)
Prednisolone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Thalidomide (Compound)
Prednisolone (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulate... |
DB00470 | DB01041 | 530 | 770 | [
"DDInter601",
"DDInter1789"
] | Dronabinol | Thalidomide | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
530,
24,
770
]
],
[
[
530,
6,
9842
],
[
9842,
45,
770
]
],
[
[
530,
21,
28714
],
[
28714,
60,
770
]
],
[
[
530,
24,
849
],
[
849,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Dronabinol",
"{u} (Compound) binds {v} (Gene)",
"CYP1A1"
],
[
"CYP1A1",
"{u} (Gene) is bound by {v} (Compound)"... | Dronabinol (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Thalidomide (Compound)
Dronabinol (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Thalidomide (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepy... |
DB00270 | DB00945 | 1,428 | 1,479 | [
"DDInter993",
"DDInter20"
] | Isradipine | Acetylsalicylic acid | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1428,
24,
1479
]
],
[
[
1428,
21,
29250
],
[
29250,
60,
1479
]
],
[
[
1428,
1,
409
],
[
409,
63,
1479
]
],
[
[
1428,
1,
1081
],
[
1081... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Isradipine",
"{u} (Compound) causes {v} (Side Effect)",
"Polyuria"
],
[
"Polyuria",
"{u} (Side Effect)... | Isradipine (Compound) causes Polyuria (Side Effect) and Polyuria (Side Effect) is caused by Acetylsalicylic acid (Compound)
Isradipine (Compound) resembles Felodipine (Compound) and Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Isradipine (Compound) rese... |
DB00494 | DB01114 | 1,533 | 272 | [
"DDInter646",
"DDInter362"
] | Entacapone | Chlorpheniramine | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1533,
24,
272
]
],
[
[
1533,
24,
849
],
[
849,
63,
272
]
],
[
[
1533,
63,
128
],
[
128,
24,
272
]
],
[
[
1533,
21,
28898
],
[
28898,
... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB01072 | DB11995 | 915 | 1,634 | [
"DDInter129",
"DDInter143"
] | Atazanavir | Avatrombopag | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Moderate | 1 | [
[
[
915,
24,
1634
]
],
[
[
915,
24,
913
],
[
913,
24,
1634
]
],
[
[
915,
63,
254
],
[
254,
24,
1634
]
],
[
[
915,
40,
1327
],
[
1327,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avatrombopag"
]
],
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
],
[... | Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Nitisinone and Ni... |
DB00867 | DB01142 | 1,052 | 1,264 | [
"DDInter1606",
"DDInter593"
] | Ritodrine | Doxepin | Adrenergic beta-agonist used to control premature labor. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1052,
24,
1264
]
],
[
[
1052,
24,
401
],
[
401,
24,
1264
]
],
[
[
1052,
63,
73
],
[
73,
24,
1264
]
],
[
[
1052,
24,
659
],
[
659,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phente... |
DB00365 | DB14491 | 839 | 428 | [
"DDInter842",
"DDInter725"
] | Grepafloxacin | Ferrous fumarate | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
839,
24,
428
]
],
[
[
839,
24,
1096
],
[
1096,
23,
428
]
],
[
[
839,
24,
115
],
[
115,
24,
428
]
],
[
[
839,
25,
1383
],
[
1383,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic ac... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB04868 | DB12095 | 478 | 179 | [
"DDInter1293",
"DDInter1760"
] | Nilotinib | Telotristat ethyl | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
478,
24,
179
]
],
[
[
478,
64,
79
],
[
79,
24,
179
]
],
[
[
478,
24,
310
],
[
310,
24,
179
]
],
[
[
478,
25,
1593
],
[
1593,
24,... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sorafenib"
],
[
"Sorafe... | Nilotinib may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may c... |
DB00533 | DB01234 | 1,416 | 1,220 | [
"DDInter1613",
"DDInter513"
] | Rofecoxib | Dexamethasone | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1416,
24,
1220
]
],
[
[
1416,
24,
870
],
[
870,
1,
1220
]
],
[
[
1416,
24,
175
],
[
175,
40,
1220
]
],
[
[
1416,
63,
251
],
[
251,
... | [
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexam... |
DB00604 | DB04953 | 1,425 | 495 | [
"DDInter385",
"DDInter708"
] | Cisapride | Ezogabine | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Major | 2 | [
[
[
1425,
25,
495
]
],
[
[
1425,
6,
8717
],
[
8717,
45,
495
]
],
[
[
1425,
23,
112
],
[
112,
23,
495
]
],
[
[
1425,
64,
1494
],
[
1494,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ezogabine"
]
],
[
[
"Cisapride",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
"CYP2A6",
"{u} (Gene) is bound by {v} (Compound)",
"Ezogabine"... | Cisapride (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Ezogabine (Compound)
Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ezogabine
Cisapride may lead t... |
DB00816 | DB01364 | 1,674 | 22 | [
"DDInter1346",
"DDInter650"
] | Orciprenaline | Ephedrine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1674,
24,
22
]
],
[
[
1674,
63,
80
],
[
80,
24,
22
]
],
[
[
1674,
24,
1529
],
[
1529,
63,
22
]
],
[
[
1674,
24,
280
],
[
280,
1,... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine ... |
DB01110 | DB08930 | 86 | 1,459 | [
"DDInter1209",
"DDInter582"
] | Miconazole | Dolutegravir | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and ... | Minor | 0 | [
[
[
86,
23,
1459
]
],
[
[
86,
21,
28722
],
[
28722,
60,
1459
]
],
[
[
86,
63,
1419
],
[
1419,
23,
1459
]
],
[
[
86,
24,
478
],
[
478,
... | [
[
[
"Miconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dolutegravir"
]
],
[
[
"Miconazole",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by ... | Miconazole (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Dolutegravir (Compound)
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a minor interaction that can limit clinical effects when taken with Dolutegravir
Mico... |
DB00366 | DB00792 | 1,594 | 832 | [
"DDInter600",
"DDInter1878"
] | Doxylamine | Tripelennamine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
1594,
24,
832
]
],
[
[
1594,
40,
11233
],
[
11233,
1,
832
]
],
[
[
1594,
1,
11775
],
[
11775,
40,
832
]
],
[
[
1594,
24,
100
],
[
100,... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Doxylamine",
"{u} (Compound) resembles {v} (Compound)",
"Dimetacrine"
],
[
"Dimetacrine",
"{u} (Compound) re... | Doxylamine (Compound) resembles Dimetacrine (Compound) and Dimetacrine (Compound) resembles Tripelennamine (Compound)
Doxylamine (Compound) resembles Chloropyramine (Compound) and Chloropyramine (Compound) resembles Tripelennamine (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases whe... |
DB00222 | DB14509 | 245 | 1,399 | [
"DDInter825",
"DDInter1081"
] | Glimepiride | Lithium carbonate | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
245,
24,
1399
]
],
[
[
245,
24,
874
],
[
874,
23,
1399
]
],
[
[
245,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
245,
63,
1685
],
[
1685,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide ... |
DB08912 | DB15822 | 1,040 | 69 | [
"DDInter462",
"DDInter1504"
] | Dabrafenib | Pralsetinib | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
1040,
24,
69
]
],
[
[
1040,
25,
283
],
[
283,
24,
69
]
],
[
[
1040,
63,
1213
],
[
1213,
24,
69
]
],
[
[
1040,
24,
985
],
[
985,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratini... | Dabrafenib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a... |
DB05273 | DB15719 | 507 | 487 | [
"DDInter1638",
"DDInter171"
] | Samarium (153Sm) lexidronam | Belantamab mafodotin | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Major | 2 | [
[
[
507,
25,
487
]
],
[
[
507,
64,
4
],
[
4,
24,
487
]
],
[
[
507,
25,
1362
],
[
1362,
24,
487
]
],
[
[
507,
24,
270
],
[
270,
24,
... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine m... | Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Samarium (153Sm) lexidronam may lead to a major life threatening inter... |
DB00759 | DB00999 | 1,620 | 504 | [
"DDInter1783",
"DDInter883"
] | Tetracycline | Hydrochlorothiazide | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Minor | 0 | [
[
[
1620,
23,
504
]
],
[
[
1620,
23,
1326
],
[
1326,
40,
504
]
],
[
[
1620,
23,
178
],
[
178,
1,
504
]
],
[
[
1620,
62,
323
],
[
323,
... | [
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Diclofenamide"
... | Tetracycline may cause a minor interaction that can limit clinical effects when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Tetracycline may cause a minor interaction that can limit clinical effects when taken with Polythiazide and Polythiazide (Compound) resembles Hyd... |
DB00439 | DB12332 | 289 | 1,619 | [
"DDInter341",
"DDInter1626"
] | Cerivastatin | Rucaparib | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
289,
24,
1619
]
],
[
[
289,
24,
112
],
[
112,
23,
1619
]
],
[
[
289,
24,
309
],
[
309,
24,
1619
]
],
[
[
289,
24,
1501
],
[
1501,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone an... |
DB00757 | DB12161 | 1,166 | 730 | [
"DDInter581",
"DDInter512"
] | Dolasetron | Deutetrabenazine | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Major | 2 | [
[
[
1166,
25,
730
]
],
[
[
1166,
23,
112
],
[
112,
23,
730
]
],
[
[
1166,
64,
322
],
[
322,
24,
730
]
],
[
[
1166,
24,
1559
],
[
1559,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Dolasetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Dolasetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Dolasetron may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin ma... |
DB01367 | DB06694 | 1,163 | 31 | [
"DDInter1572",
"DDInter1952"
] | Rasagiline | Xylometazoline (nasal) | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Xylometazoline is an alkylbenzene. | Moderate | 1 | [
[
[
1163,
24,
31
]
],
[
[
1163,
24,
144
],
[
144,
63,
31
]
],
[
[
1163,
63,
1148
],
[
1148,
24,
31
]
],
[
[
1163,
25,
1629
],
[
1629,
... | [
[
[
"Rasagiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Xylometazoline"
]
],
[
[
"Rasagiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
],
... | Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Ra... |
DB00627 | DB00641 | 265 | 467 | [
"DDInter1286",
"DDInter1675"
] | Niacin | Simvastatin | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Major | 2 | [
[
[
265,
25,
467
]
],
[
[
265,
5,
11596
],
[
11596,
44,
467
]
],
[
[
265,
6,
12523
],
[
12523,
45,
467
]
],
[
[
265,
7,
11074
],
[
11074,
... | [
[
[
"Niacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Simvastatin"
]
],
[
[
"Niacin",
"{u} (Compound) treats {v} (Disease)",
"atherosclerosis"
],
[
"atherosclerosis",
"{u} (Disease) is treated by {v} (Compou... | Niacin (Compound) treats atherosclerosis (Disease) and atherosclerosis (Disease) is treated by Simvastatin (Compound)
Niacin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Simvastatin (Compound)
Niacin (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Simvastatin (Compound)
Niacin (Co... |
DB00726 | DB01067 | 1,164 | 959 | [
"DDInter1876",
"DDInter826"
] | Trimipramine | Glipizide | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1164,
24,
959
]
],
[
[
1164,
63,
245
],
[
245,
40,
959
]
],
[
[
1164,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1164,
6,
8374
],
[
8374,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Comp... |
DB00445 | DB00621 | 322 | 1,026 | [
"DDInter655",
"DDInter1357"
] | Epirubicin | Oxandrolone | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | A synthetic hormone with anabolic and androgenic properties. | Moderate | 1 | [
[
[
322,
24,
1026
]
],
[
[
322,
24,
1546
],
[
1546,
1,
1026
]
],
[
[
322,
7,
5002
],
[
5002,
46,
1026
]
],
[
[
322,
21,
28799
],
[
28799,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
],... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Oxandrolone (Compound)
Epirubicin (Compound) upregulates SNAP25 (Gene) and SNAP25 (Gene) is upregulated by Oxandrolone (Compound)
Epirubicin (Compound) causes Neoplas... |
DB00039 | DB11952 | 1,253 | 800 | [
"DDInter1380",
"DDInter612"
] | Palifermin | Duvelisib | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1253,
24,
800
]
],
[
[
1253,
24,
310
],
[
310,
24,
800
]
],
[
[
1253,
24,
564
],
[
564,
63,
800
]
],
[
[
1253,
24,
866
],
[
866,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib and Abem... |
DB00285 | DB06691 | 1,100 | 849 | [
"DDInter1927",
"DDInter1155"
] | Venlafaxine | Mepyramine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1100,
24,
849
]
],
[
[
1100,
24,
1594
],
[
1594,
24,
849
]
],
[
[
1100,
6,
12523
],
[
12523,
45,
849
]
],
[
[
1100,
63,
1648
],
[
1648... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Venlafaxine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Venlafaxine may ... |
DB00189 | DB06282 | 459 | 516 | [
"DDInter691",
"DDInter1053"
] | Ethchlorvynol | Levocetirizine | Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
459,
24,
516
]
],
[
[
459,
24,
701
],
[
701,
24,
516
]
],
[
[
459,
24,
407
],
[
407,
63,
516
]
],
[
[
459,
63,
1648
],
[
1648,
2... | [
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
]... | Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Opium and O... |
DB00738 | DB01132 | 485 | 1,130 | [
"DDInter1420",
"DDInter1472"
] | Pentamidine | Pioglitazone | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
485,
24,
1130
]
],
[
[
485,
6,
12523
],
[
12523,
45,
1130
]
],
[
[
485,
7,
1843
],
[
1843,
46,
1130
]
],
[
[
485,
21,
28778
],
[
28778... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Pentamidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pioglitazone (Compound)
Pentamidine (Compound) upregulates PPARD (Gene) and PPARD (Gene) is upregulated by Pioglitazone (Compound)
Pentamidine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pio... |
DB06211 | DB09268 | 1,526 | 1,662 | [
"DDInter586",
"DDInter1464"
] | Doripenem | Picosulfuric acid | Doripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and ci... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1526,
24,
1662
]
],
[
[
1526,
63,
1096
],
[
1096,
63,
597
],
[
597,
24,
1662
]
],
[
[
1526,
63,
1096
],
[
1096,
24,
1558
],
[
1558,
... | [
[
[
"Doripenem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Doripenem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Doripenem may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken... |
DB00853 | DB01165 | 1,686 | 1,539 | [
"DDInter1762",
"DDInter1325"
] | Temozolomide | Ofloxacin | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Minor | 0 | [
[
[
1686,
23,
1539
]
],
[
[
1686,
62,
1467
],
[
1467,
1,
1539
]
],
[
[
1686,
23,
945
],
[
945,
40,
1539
]
],
[
[
1686,
23,
739
],
[
739,
... | [
[
[
"Temozolomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
]
],
[
[
"Temozolomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
... | Temozolomide may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Temozolomide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Te... |
DB00687 | DB01377 | 870 | 1,283 | [
"DDInter747",
"DDInter1119"
] | Fludrocortisone | Magnesium oxide | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
870,
23,
1283
]
],
[
[
870,
24,
743
],
[
743,
23,
1283
]
],
[
[
870,
63,
684
],
[
684,
23,
1283
]
],
[
[
870,
24,
1482
],
[
1482,
... | [
[
[
"Fludrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Thiorida... |
DB09330 | DB11642 | 985 | 938 | [
"DDInter1352",
"DDInter1480"
] | Osimertinib | Pitolisant | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Major | 2 | [
[
[
985,
25,
938
]
],
[
[
985,
62,
112
],
[
112,
23,
938
]
],
[
[
985,
64,
760
],
[
760,
24,
938
]
],
[
[
985,
63,
28
],
[
28,
24,
... | [
[
[
"Osimertinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pitolisant"
]
],
[
[
"Osimertinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Osimertinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Osimertinib may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may ca... |
DB06772 | DB12141 | 310 | 971 | [
"DDInter259",
"DDInter817"
] | Cabazitaxel | Gilteritinib | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
310,
24,
971
]
],
[
[
310,
63,
112
],
[
112,
23,
971
]
],
[
[
310,
24,
1097
],
[
1097,
24,
971
]
],
[
[
310,
63,
1335
],
[
1335,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan an... |
DB00851 | DB14443 | 611 | 987 | [
"DDInter463",
"DDInter1931"
] | Dacarbazine | Vibrio cholerae CVD 103-HgR strain live antigen | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
611,
24,
987
]
],
[
[
611,
63,
141
],
[
141,
24,
987
]
],
[
[
611,
24,
1488
],
[
1488,
24,
987
]
],
[
[
611,
64,
581
],
[
581,
2... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Dacarbazine may cause a moderate interaction that could exacerbate disea... |
DB00619 | DB00675 | 1,419 | 888 | [
"DDInter909",
"DDInter1744"
] | Imatinib | Tamoxifen | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
1419,
24,
888
]
],
[
[
1419,
24,
1405
],
[
1405,
40,
888
]
],
[
[
1419,
6,
4973
],
[
4973,
45,
888
]
],
[
[
1419,
7,
8924
],
[
8924,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine (Compound) resembles Tamoxifen (Compound)
Imatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Tamoxifen (Compound)
Imatinib (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is... |
DB00562 | DB01240 | 1,014 | 885 | [
"DDInter188",
"DDInter657"
] | Benzthiazide | Epoprostenol | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1014,
24,
885
]
],
[
[
1014,
63,
1061
],
[
1061,
1,
885
]
],
[
[
1014,
24,
1512
],
[
1512,
24,
885
]
],
[
[
1014,
24,
1450
],
[
1450,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction ... |
DB00475 | DB01075 | 1,119 | 1,376 | [
"DDInter355",
"DDInter569"
] | Chlordiazepoxide | Diphenhydramine | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1119,
24,
1376
]
],
[
[
1119,
24,
649
],
[
649,
63,
1376
]
],
[
[
1119,
63,
128
],
[
128,
24,
1376
]
],
[
[
1119,
24,
832
],
[
832,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Dexb... |
DB00361 | DB01076 | 134 | 700 | [
"DDInter1939",
"DDInter133"
] | Vinorelbine | Atorvastatin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
134,
24,
700
]
],
[
[
134,
25,
1080
],
[
1080,
1,
700
]
],
[
[
134,
24,
788
],
[
788,
1,
700
]
],
[
[
134,
6,
12523
],
[
12523,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Coniva... | Vinorelbine may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Atorvastatin (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Atorvastatin (Compound)
Vinor... |
DB00365 | DB08820 | 839 | 1,478 | [
"DDInter842",
"DDInter997"
] | Grepafloxacin | Ivacaftor | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
839,
24,
1478
]
],
[
[
839,
24,
543
],
[
543,
24,
1478
]
],
[
[
839,
25,
1411
],
[
1411,
24,
1478
]
],
[
[
839,
25,
985
],
[
985,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
],
... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor
Grepafloxacin may lead to a major life threatening interaction when taken with Tolbutamide and Tolbutamide may... |
DB01041 | DB11901 | 770 | 913 | [
"DDInter1789",
"DDInter107"
] | Thalidomide | Apalutamide | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
770,
24,
913
]
],
[
[
770,
63,
112
],
[
112,
23,
913
]
],
[
[
770,
24,
110
],
[
110,
62,
913
]
],
[
[
770,
63,
1322
],
[
1322,
2... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab ve... |
DB00526 | DB01403 | 1,555 | 9 | [
"DDInter1355",
"DDInter1175"
] | Oxaliplatin | Methotrimeprazine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1555,
24,
9
]
],
[
[
1555,
24,
1178
],
[
1178,
40,
9
]
],
[
[
1555,
24,
1164
],
[
1164,
1,
9
]
],
[
[
1555,
25,
684
],
[
684,
40... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles... |
DB01157 | DB06168 | 304 | 1,531 | [
"DDInter1875",
"DDInter281"
] | Trimetrexate | Canakinumab | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
304,
24,
1531
]
],
[
[
304,
24,
1270
],
[
1270,
63,
1531
]
],
[
[
304,
63,
599
],
[
599,
24,
1531
]
],
[
[
304,
24,
1683
],
[
1683,
... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified pr... | Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Trimetrexate may cause a moderate interaction that co... |
DB01259 | DB08931 | 392 | 947 | [
"DDInter1024",
"DDInter1600"
] | Lapatinib | Riociguat | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Moderate | 1 | [
[
[
392,
24,
947
]
],
[
[
392,
63,
379
],
[
379,
24,
947
]
],
[
[
392,
24,
1478
],
[
1478,
24,
947
]
],
[
[
392,
64,
609
],
[
609,
2... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riociguat"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
[
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Riociguat
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacafto... |
DB10315 | DB11714 | 1,137 | 1,316 | [
"DDInter1127",
"DDInter610"
] | Measles virus vaccine live attenuated | Durvalumab | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Major | 2 | [
[
[
1137,
25,
1316
]
],
[
[
1137,
64,
167
],
[
167,
24,
1316
]
],
[
[
1137,
25,
270
],
[
270,
63,
1316
]
],
[
[
1137,
63,
617
],
[
617,
... | [
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Durvalumab"
]
],
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hyd... | Measles virus vaccine live attenuated may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Durvalumab
Measles virus vaccine live attenuated may lead to a major life threatening interaction when ... |
DB05273 | DB13007 | 507 | 1,060 | [
"DDInter1638",
"DDInter642"
] | Samarium (153Sm) lexidronam | Enfortumab vedotin | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Major | 2 | [
[
[
507,
25,
1060
]
],
[
[
507,
24,
270
],
[
270,
24,
1060
]
],
[
[
507,
25,
350
],
[
350,
24,
1060
]
],
[
[
507,
64,
268
],
[
268,
... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Samarium (153Sm) lexidronam may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Samarium (153Sm) lexidronam may lead to a major life threatening interaction when tak... |
DB00475 | DB01205 | 1,119 | 1,404 | [
"DDInter355",
"DDInter748"
] | Chlordiazepoxide | Flumazenil | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. | Moderate | 1 | [
[
[
1119,
24,
1404
]
],
[
[
1119,
6,
13500
],
[
13500,
45,
1404
]
],
[
[
1119,
1,
902
],
[
902,
24,
1404
]
],
[
[
1119,
40,
1382
],
[
1382... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flumazenil"
]
],
[
[
"Chlordiazepoxide",
"{u} (Compound) binds {v} (Gene)",
"GABRA5"
],
[
"GABRA5",
"{u} (Gene) is bound by {v} ... | Chlordiazepoxide (Compound) binds GABRA5 (Gene) and GABRA5 (Gene) is bound by Flumazenil (Compound)
Chlordiazepoxide (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Chlordiazepoxide (Compound) resembles Midazolam (Compound)... |
DB00762 | DB01234 | 613 | 1,220 | [
"DDInter973",
"DDInter513"
] | Irinotecan | Dexamethasone | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
613,
24,
1220
]
],
[
[
613,
5,
11555
],
[
11555,
44,
1220
]
],
[
[
613,
6,
21998
],
[
21998,
45,
1220
]
],
[
[
613,
7,
7720
],
[
7720,... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Irinotecan",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Dis... | Irinotecan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dexamethasone (Compound)
Irinotecan (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Dexamethasone (Compound)
Irinotecan (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by... |
DB00471 | DB01320 | 201 | 651 | [
"DDInter1242",
"DDInter783"
] | Montelukast | Fosphenytoin | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
201,
24,
651
]
],
[
[
201,
63,
362
],
[
362,
1,
651
]
],
[
[
201,
24,
998
],
[
998,
1,
651
]
],
[
[
201,
6,
6017
],
[
6017,
45,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[... | Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Fosphenytoin... |
DB00598 | DB00635 | 1,523 | 1,573 | [
"DDInter1013",
"DDInter1515"
] | Labetalol | Prednisone | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
1523,
24,
1573
]
],
[
[
1523,
24,
175
],
[
175,
40,
1573
]
],
[
[
1523,
63,
251
],
[
251,
1,
1573
]
],
[
[
1523,
24,
167
],
[
167,
... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Prednisone (... |
DB05239 | DB11613 | 866 | 1,519 | [
"DDInter425",
"DDInter1924"
] | Cobimetinib | Velpatasvir | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Moderate | 1 | [
[
[
866,
24,
1519
]
],
[
[
866,
24,
1374
],
[
1374,
24,
1519
]
],
[
[
866,
25,
384
],
[
384,
24,
1519
]
],
[
[
866,
63,
869
],
[
869,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Velpatasvir"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Velpatasvir
Cobimetinib may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may c... |
DB00740 | DB09074 | 424 | 1,362 | [
"DDInter1596",
"DDInter1327"
] | Riluzole | Olaparib | A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
424,
24,
1362
]
],
[
[
424,
62,
1684
],
[
1684,
24,
1362
]
],
[
[
424,
24,
1619
],
[
1619,
63,
1362
]
],
[
[
424,
63,
702
],
[
702,
... | [
[
[
"Riluzole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Riluzole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Caffeine"
],
[
"Caffe... | Riluzole may cause a minor interaction that can limit clinical effects when taken with Caffeine and Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Riluzole may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause... |
DB01075 | DB05381 | 1,376 | 172 | [
"DDInter569",
"DDInter863"
] | Diphenhydramine | Histamine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Moderate | 1 | [
[
[
1376,
24,
172
]
],
[
[
1376,
35,
1264
],
[
1264,
24,
172
]
],
[
[
1376,
24,
1237
],
[
1237,
24,
172
]
],
[
[
1376,
63,
1242
],
[
1242,... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histamine"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases whe... | Diphenhydramine (Compound) resembles Doxepin (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Histamine
Diphenhydramine may cause a moderate interaction that ... |
DB00924 | DB01114 | 1,405 | 272 | [
"DDInter454",
"DDInter362"
] | Cyclobenzaprine | Chlorpheniramine | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1405,
24,
272
]
],
[
[
1405,
40,
358
],
[
358,
63,
272
]
],
[
[
1405,
40,
11244
],
[
11244,
1,
272
]
],
[
[
1405,
24,
849
],
[
849,
... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Cyclobenzaprine",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine",
"{u}... | Cyclobenzaprine (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Cyclobenzaprine (Compound) resembles Pheniramine (Compound) and Pheniramine (Compound) resembles Chlorpheniramine (Compound)
Cyclobenzaprine may ... |
DB00008 | DB11793 | 491 | 738 | [
"DDInter1407",
"DDInter1297"
] | Peginterferon alfa-2a | Niraparib | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
491,
24,
738
]
],
[
[
491,
24,
663
],
[
663,
24,
738
]
],
[
[
491,
24,
287
],
[
287,
63,
738
]
],
[
[
491,
25,
1101
],
[
1101,
2... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methot... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken w... |
DB06203 | DB06595 | 1,002 | 1,491 | [
"DDInter51",
"DDInter1214"
] | Alogliptin | Midostaurin | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1002,
24,
1491
]
],
[
[
1002,
63,
1148
],
[
1148,
24,
1491
]
],
[
[
1002,
24,
659
],
[
659,
63,
1491
]
],
[
[
1002,
1,
1281
],
[
1281,... | [
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[... | Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and V... |
DB00853 | DB10583 | 1,686 | 949 | [
"DDInter1762",
"DDInter415"
] | Temozolomide | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1686,
24,
949
]
],
[
[
1686,
63,
589
],
[
589,
24,
949
]
],
[
[
1686,
25,
1377
],
[
1377,
24,
949
]
],
[
[
1686,
25,
1259
],
[
1259,
... | [
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases wh... | Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Temozolomide may lead to a major life threatening interaction ... |
DB00046 | DB09381 | 1,179 | 192 | [
"DDInter940",
"DDInter678"
] | Insulin lispro | Esterified estrogens | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1179,
24,
192
]
],
[
[
1179,
24,
1019
],
[
1019,
63,
192
]
],
[
[
1179,
24,
5
],
[
5,
24,
192
]
],
[
[
1179,
24,
1019
],
[
1019,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazaco... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with L... |
DB00448 | DB00688 | 1,215 | 955 | [
"DDInter1022",
"DDInter1251"
] | Lansoprazole | Mycophenolate mofetil | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Moderate | 1 | [
[
[
1215,
24,
955
]
],
[
[
1215,
6,
17404
],
[
17404,
45,
955
]
],
[
[
1215,
21,
29233
],
[
29233,
60,
955
]
],
[
[
1215,
24,
428
],
[
428... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolate mofetil"
]
],
[
[
"Lansoprazole",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v}... | Lansoprazole (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Mycophenolate mofetil (Compound)
Lansoprazole (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Mycophenolate mofetil (Compound)
Lansoprazole may cause a moderate interaction that could exacerb... |
DB09079 | DB14761 | 1,496 | 242 | [
"DDInter1296",
"DDInter1578"
] | Nintedanib | Remdesivir | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1496,
24,
242
]
],
[
[
1496,
64,
1377
],
[
1377,
24,
242
]
],
[
[
1496,
63,
129
],
[
129,
24,
242
]
],
[
[
1496,
24,
971
],
[
971,
... | [
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Nintedanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
[
"Leflunomi... | Nintedanib may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may ... |
DB01075 | DB04843 | 1,376 | 1,511 | [
"DDInter569",
"DDInter1149"
] | Diphenhydramine | Mepenzolate | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1376,
24,
1511
]
],
[
[
1376,
64,
675
],
[
675,
24,
1511
]
],
[
[
1376,
35,
537
],
[
537,
24,
1511
]
],
[
[
1376,
63,
1192
],
[
1192,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Diphenhydramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
],
... | Diphenhydramine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Diphenhydramine (Compound) resembles Cyclizine (Compound) and Diphenhydramine may cause a moderate intera... |
DB00593 | DB11901 | 1,464 | 913 | [
"DDInter695",
"DDInter107"
] | Ethosuximide | Apalutamide | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1464,
24,
913
]
],
[
[
1464,
63,
600
],
[
600,
24,
913
]
],
[
[
1464,
24,
1619
],
[
1619,
63,
913
]
],
[
[
1464,
24,
401
],
[
401,
... | [
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
... | Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and ... |
DB00563 | DB05812 | 663 | 1,374 | [
"DDInter1174",
"DDInter8"
] | Methotrexate | Abiraterone | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
663,
24,
1374
]
],
[
[
663,
24,
1561
],
[
1561,
1,
1374
]
],
[
[
663,
6,
10417
],
[
10417,
45,
1374
]
],
[
[
663,
21,
28809
],
[
28809... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) resembles Abiraterone (Compound)
Methotrexate (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Abiraterone (Compound)
Methotrexate (Compound) causes Diarrhoea (Side Effect) and... |
DB01157 | DB10795 | 304 | 221 | [
"DDInter1875",
"DDInter1486"
] | Trimetrexate | Poliovirus type 1 antigen (formaldehyde inactivated) | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
304,
24,
221
]
],
[
[
304,
64,
581
],
[
581,
24,
221
]
],
[
[
304,
63,
599
],
[
599,
24,
221
]
],
[
[
304,
24,
384
],
[
384,
24,... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Trimetrexate may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Trimetrexate may cause a moderate interaction that could exacerbate diseases when t... |
DB01246 | DB08875 | 820 | 1,618 | [
"DDInter45",
"DDInter262"
] | Alimemazine | Cabozantinib | A phenothiazine derivative that is used as an antipruritic. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
820,
25,
1618
]
],
[
[
820,
62,
112
],
[
112,
23,
1618
]
],
[
[
820,
24,
1032
],
[
1032,
63,
1618
]
],
[
[
820,
63,
122
],
[
122,
... | [
[
[
"Alimemazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Alimemazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Alimemazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol ... |
DB04865 | DB08886 | 4 | 637 | [
"DDInter1335",
"DDInter126"
] | Omacetaxine mepesuccinate | Asparaginase Erwinia chrysanthemi | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
4,
24,
637
]
],
[
[
4,
63,
491
],
[
491,
24,
637
]
],
[
[
4,
24,
250
],
[
250,
63,
637
]
],
[
[
4,
24,
5
],
[
5,
24,
637
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases whe... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Omacetaxine mepesuccinate may cause a moderate inter... |
DB01142 | DB06699 | 1,264 | 774 | [
"DDInter593",
"DDInter493"
] | Doxepin | Degarelix | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
1264,
24,
774
]
],
[
[
1264,
63,
521
],
[
521,
1,
774
]
],
[
[
1264,
21,
29232
],
[
29232,
60,
774
]
],
[
[
1264,
62,
112
],
[
112,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
"Gos... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Doxepin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Doxepin may cause a minor interaction that can limit c... |
DB00762 | DB08873 | 613 | 74 | [
"DDInter973",
"DDInter221"
] | Irinotecan | Boceprevir | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Major | 2 | [
[
[
613,
25,
74
]
],
[
[
613,
6,
4973
],
[
4973,
45,
74
]
],
[
[
613,
21,
28821
],
[
28821,
60,
74
]
],
[
[
613,
24,
1374
],
[
1374,
... | [
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Boceprevir"
]
],
[
[
"Irinotecan",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Boceprevi... | Irinotecan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Boceprevir (Compound)
Irinotecan (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Boceprevir (Compound)
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone... |
DB00087 | DB12240 | 599 | 110 | [
"DDInter41",
"DDInter1485"
] | Alemtuzumab | Polatuzumab vedotin | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
599,
24,
110
]
],
[
[
599,
24,
1419
],
[
1419,
24,
110
]
],
[
[
599,
63,
268
],
[
268,
24,
110
]
],
[
[
599,
24,
1619
],
[
1619,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon ... |
DB00372 | DB00572 | 999 | 85 | [
"DDInter1793",
"DDInter136"
] | Thiethylperazine | Atropine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
999,
24,
85
]
],
[
[
999,
24,
19
],
[
19,
24,
85
]
],
[
[
999,
63,
357
],
[
357,
24,
85
]
],
[
[
999,
24,
1177
],
[
1177,
40,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Benzatrop... |
DB01267 | DB08907 | 519 | 1,344 | [
"DDInter1381",
"DDInter280"
] | Paliperidone | Canagliflozin | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
519,
24,
1344
]
],
[
[
519,
24,
549
],
[
549,
1,
1344
]
],
[
[
519,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
519,
21,
28873
],
[
28873,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Paliperidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Paliperidone (Compound) causes Pancreatitis (Side ... |
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