drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01060 | DB09420 | 319 | 1,074 | [
"DDInter83",
"DDInter953"
] | Amoxicillin | Iodide I-123 | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
319,
24,
1074
]
],
[
[
319,
40,
339
],
[
339,
24,
1074
]
],
[
[
319,
63,
126
],
[
126,
24,
1074
]
],
[
[
319,
1,
1681
],
[
1681,
... | [
[
[
"Amoxicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Amoxicillin",
"{u} (Compound) resembles {v} (Compound)",
"Bacampicillin"
],
[
"Bacampicillin",
"{u} may cause... | Amoxicillin (Compound) resembles Bacampicillin (Compound) and Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Amoxicillin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that... |
DB00398 | DB11967 | 79 | 710 | [
"DDInter1702",
"DDInter210"
] | Sorafenib | Binimetinib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
79,
24,
710
]
],
[
[
79,
24,
1293
],
[
1293,
24,
710
]
],
[
[
79,
25,
1593
],
[
1593,
24,
710
]
],
[
[
79,
24,
733
],
[
733,
63,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine and Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Sorafenib may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause... |
DB00531 | DB09118 | 450 | 1,580 | [
"DDInter456",
"DDInter1711"
] | Cyclophosphamide | Stiripentol | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
450,
24,
1580
]
],
[
[
450,
35,
1532
],
[
1532,
24,
1580
]
],
[
[
450,
24,
473
],
[
473,
24,
1580
]
],
[
[
450,
63,
1324
],
[
1324,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases... | Cyclophosphamide (Compound) resembles Ifosfamide (Compound) and Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Cyclophosphamide may cause a moderate int... |
DB00041 | DB01249 | 1,648 | 258 | [
"DDInter38",
"DDInter958"
] | Aldesleukin | Iodixanol | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Moderate | 1 | [
[
[
1648,
24,
258
]
],
[
[
1648,
25,
497
],
[
497,
1,
258
]
],
[
[
1648,
24,
443
],
[
443,
24,
258
]
],
[
[
1648,
24,
178
],
[
178,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
]
],
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
... | Aldesleukin may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a moderate interaction that could exacerbate ... |
DB01238 | DB01612 | 673 | 1,637 | [
"DDInter118",
"DDInter92"
] | Aripiprazole | Amyl Nitrite | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
673,
24,
1637
]
],
[
[
673,
64,
475
],
[
475,
24,
1637
]
],
[
[
673,
63,
401
],
[
401,
24,
1637
]
],
[
[
673,
24,
820
],
[
820,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Aripiprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphi... | Aripiprazole may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may ... |
DB00490 | DB01191 | 946 | 1,039 | [
"DDInter254",
"DDInter518"
] | Buspirone | Dexfenfluramine | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
946,
25,
1039
]
],
[
[
946,
6,
6962
],
[
6962,
45,
1039
]
],
[
[
946,
24,
868
],
[
868,
63,
1039
]
],
[
[
946,
63,
13
],
[
13,
2... | [
[
[
"Buspirone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Buspirone",
"{u} (Compound) binds {v} (Gene)",
"HTR2B"
],
[
"HTR2B",
"{u} (Gene) is bound by {v} (Compound)",
"Dexfen... | Buspirone (Compound) binds HTR2B (Gene) and HTR2B (Gene) is bound by Dexfenfluramine (Compound)
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Buspirone ... |
DB00209 | DB00333 | 352 | 576 | [
"DDInter1886",
"DDInter1166"
] | Trospium | Methadone | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Moderate | 1 | [
[
[
352,
24,
576
]
],
[
[
352,
35,
194
],
[
194,
40,
576
]
],
[
[
352,
24,
494
],
[
494,
40,
576
]
],
[
[
352,
24,
1164
],
[
1164,
1... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methadone"
]
],
[
[
"Trospium",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Trospium (Compound) resembles Darifenacin (Compound) and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin and Darifenacin (Compound) resembles Methadone (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide an... |
DB00295 | DB01392 | 475 | 425 | [
"DDInter1244",
"DDInter1954"
] | Morphine | Yohimbine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. | Minor | 0 | [
[
[
475,
23,
425
]
],
[
[
475,
6,
12523
],
[
12523,
45,
425
]
],
[
[
475,
25,
1053
],
[
1053,
24,
425
]
],
[
[
475,
24,
1264
],
[
1264,
... | [
[
[
"Morphine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Yohimbine"
]
],
[
[
"Morphine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Morphine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Yohimbine (Compound)
Morphine may lead to a major life threatening interaction when taken with Procarbazine and Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Yohimbine
Morphine may cause a moderate inter... |
DB00712 | DB11095 | 1,274 | 235 | [
"DDInter763",
"DDInter505"
] | Flurbiprofen | Desirudin | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
1274,
25,
235
]
],
[
[
1274,
23,
297
],
[
297,
23,
235
]
],
[
[
1274,
63,
1100
],
[
1100,
24,
235
]
],
[
[
1274,
24,
643
],
[
643,
... | [
[
[
"Flurbiprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Flurbiprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
... | Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may ... |
DB00726 | DB01191 | 1,164 | 1,039 | [
"DDInter1876",
"DDInter518"
] | Trimipramine | Dexfenfluramine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
1164,
25,
1039
]
],
[
[
1164,
6,
6112
],
[
6112,
45,
1039
]
],
[
[
1164,
24,
1045
],
[
1045,
63,
1039
]
],
[
[
1164,
25,
868
],
[
868,... | [
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Trimipramine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A4"
],
[
"SLC6A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Trimipramine (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Dexfenfluramine (Compound)
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib and Dacomitinib may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Tr... |
DB00903 | DB01017 | 1,680 | 1,669 | [
"DDInter686",
"DDInter1224"
] | Etacrynic acid | Minocycline | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Minor | 0 | [
[
[
1680,
23,
1669
]
],
[
[
1680,
62,
1572
],
[
1572,
1,
1669
]
],
[
[
1680,
62,
1545
],
[
1545,
40,
1669
]
],
[
[
1680,
18,
6797
],
[
679... | [
[
[
"Etacrynic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Minocycline"
]
],
[
[
"Etacrynic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Demeclocycline"
],... | Etacrynic acid may cause a minor interaction that can limit clinical effects when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Etacrynic acid may cause a minor interaction that can limit clinical effects when taken with Oxytetracycline and Oxytetracycline (Compound) resembles... |
DB00074 | DB06643 | 1,309 | 1,136 | [
"DDInter166",
"DDInter500"
] | Basiliximab | Denosumab | A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermenta... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
1309,
24,
1136
]
],
[
[
1309,
25,
1377
],
[
1377,
24,
1136
]
],
[
[
1309,
25,
1510
],
[
1510,
63,
1136
]
],
[
[
1309,
24,
270
],
[
270... | [
[
[
"Basiliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Basiliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
[
"Leflunom... | Basiliximab may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Basiliximab may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a mode... |
DB06772 | DB12834 | 310 | 148 | [
"DDInter259",
"DDInter1649"
] | Cabazitaxel | Secnidazole | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
310,
24,
148
]
],
[
[
310,
24,
1593
],
[
1593,
24,
148
]
],
[
[
310,
63,
1191
],
[
1191,
24,
148
]
],
[
[
310,
25,
1510
],
[
1510,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levod... |
DB00662 | DB00899 | 717 | 411 | [
"DDInter1873",
"DDInter1579"
] | Trimethobenzamide | Remifentanil | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Moderate | 1 | [
[
[
717,
24,
411
]
],
[
[
717,
24,
1322
],
[
1322,
40,
411
]
],
[
[
717,
24,
704
],
[
704,
1,
411
]
],
[
[
717,
63,
1349
],
[
1349,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfentanil"... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Alfentanil and Alfentanil (Compound) resembles Remifentanil (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Remifentan... |
DB00753 | DB01142 | 1,280 | 1,264 | [
"DDInter983",
"DDInter593"
] | Isoflurane | Doxepin | A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1280,
24,
1264
]
],
[
[
1280,
21,
29282
],
[
29282,
60,
1264
]
],
[
[
1280,
1,
419
],
[
419,
63,
1264
]
],
[
[
1280,
24,
407
],
[
407,... | [
[
[
"Isoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Isoflurane",
"{u} (Compound) causes {v} (Side Effect)",
"Arrhythmia"
],
[
"Arrhythmia",
"{u} (Side Effect) is cause... | Isoflurane (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Doxepin (Compound)
Isoflurane (Compound) resembles Halothane (Compound) and Halothane may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Isoflurane may cause a moderate interaction that c... |
DB00445 | DB00640 | 322 | 1,585 | [
"DDInter655",
"DDInter31"
] | Epirubicin | Adenosine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Moderate | 1 | [
[
[
322,
24,
1585
]
],
[
[
322,
24,
1224
],
[
1224,
40,
1585
]
],
[
[
322,
64,
1064
],
[
1064,
1,
1585
]
],
[
[
322,
24,
372
],
[
372,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Adenosine"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Adenosine (Compound)
Epirubicin may lead to a major life threatening interaction when taken with Cladribine and Cladribine (Compound) resembles Adenosine (Compound)
Epirubicin may ca... |
DB01197 | DB08894 | 1,603 | 1,126 | [
"DDInter292",
"DDInter1406"
] | Captopril | Peginesatide | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of th... | Minor | 0 | [
[
[
1603,
23,
1126
]
],
[
[
1603,
40,
610
],
[
610,
23,
1126
]
],
[
[
1603,
63,
1144
],
[
1144,
63,
610
],
[
610,
23,
1126
]
],
[
[
1603,
... | [
[
[
"Captopril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Peginesatide"
]
],
[
[
"Captopril",
"{u} (Compound) resembles {v} (Compound)",
"Enalapril"
],
[
"Enalapril",
"{u} may cause a minor inter... | Captopril (Compound) resembles Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could e... |
DB00635 | DB01359 | 1,573 | 729 | [
"DDInter1515",
"DDInter1417"
] | Prednisone | Penbutolol | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
1573,
24,
729
]
],
[
[
1573,
63,
461
],
[
461,
1,
729
]
],
[
[
1573,
24,
699
],
[
699,
40,
729
]
],
[
[
1573,
21,
28698
],
[
28698,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Prednisone (... |
DB01177 | DB01211 | 77 | 609 | [
"DDInter904",
"DDInter393"
] | Idarubicin | Clarithromycin | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
77,
24,
609
]
],
[
[
77,
63,
1570
],
[
1570,
24,
609
]
],
[
[
77,
7,
3466
],
[
3466,
46,
609
]
],
[
[
77,
18,
7248
],
[
7248,
46... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Idarubicin (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Clarithromycin (Compou... |
DB00526 | DB08908 | 1,555 | 713 | [
"DDInter1355",
"DDInter564"
] | Oxaliplatin | Dimethyl fumarate | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1555,
24,
713
]
],
[
[
1555,
25,
996
],
[
996,
24,
713
]
],
[
[
1555,
24,
4
],
[
4,
24,
713
]
],
[
[
1555,
63,
552
],
[
552,
24,... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
],
[
"... | Oxaliplatin may lead to a major life threatening interaction when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate... |
DB00367 | DB11834 | 566 | 1,303 | [
"DDInter1061",
"DDInter849"
] | Levonorgestrel | Guselkumab | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
566,
24,
1303
]
],
[
[
566,
63,
58
],
[
58,
24,
1303
]
],
[
[
566,
1,
1336
],
[
1336,
24,
1303
]
],
[
[
566,
24,
259
],
[
259,
2... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
... | Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Levonorgestrel (Compound) resembles Etonogestrel (Compound) and Etonogestrel may cause a moderate interaction ... |
DB00401 | DB11767 | 84 | 1,583 | [
"DDInter1298",
"DDInter1643"
] | Nisoldipine | Sarilumab | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
84,
24,
1583
]
],
[
[
84,
1,
1081
],
[
1081,
24,
1583
]
],
[
[
84,
40,
854
],
[
854,
24,
1583
]
],
[
[
84,
24,
384
],
[
384,
24,... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Nisoldipine",
"{u} (Compound) resembles {v} (Compound)",
"Nicardipine"
],
[
"Nicardipine",
"{u} may cause a mode... | Nisoldipine (Compound) resembles Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Nisoldipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Sariluma... |
DB08871 | DB09330 | 36 | 985 | [
"DDInter666",
"DDInter1352"
] | Eribulin | Osimertinib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
36,
25,
985
]
],
[
[
36,
63,
168
],
[
168,
23,
985
]
],
[
[
36,
62,
1247
],
[
1247,
23,
985
]
],
[
[
36,
63,
134
],
[
134,
24,
... | [
[
[
"Eribulin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Eribulin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfame... |
DB00227 | DB00631 | 1,463 | 372 | [
"DDInter1098",
"DDInter405"
] | Lovastatin | Clofarabine | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
1463,
24,
372
]
],
[
[
1463,
24,
1488
],
[
1488,
40,
372
]
],
[
[
1463,
7,
1990
],
[
1990,
46,
372
]
],
[
[
1463,
18,
2900
],
[
2900,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine (Compound) resembles Clofarabine (Compound)
Lovastatin (Compound) upregulates JUN (Gene) and JUN (Gene) is upregulated by Clofarabine (Compound)
Lovastatin (Compound) downregulates NFKBIA (Gene) and NF... |
DB00163 | DB12364 | 1,461 | 1,421 | [
"DDInter1943",
"DDInter200"
] | Vitamin E | Betrixaban | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
1461,
24,
1421
]
],
[
[
1461,
24,
298
],
[
298,
24,
1421
]
],
[
[
1461,
24,
714
],
[
714,
25,
1421
]
],
[
[
1461,
63,
1432
],
[
1432,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Protein C and Protein C may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may... |
DB00004 | DB14783 | 669 | 287 | [
"DDInter499",
"DDInter574"
] | Denileukin diftitox | Diroximel fumarate | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
669,
24,
287
]
],
[
[
669,
24,
384
],
[
384,
24,
287
]
],
[
[
669,
25,
770
],
[
770,
24,
287
]
],
[
[
669,
25,
1510
],
[
1510,
2... | [
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"I... | Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Denileukin diftitox may lead to a major life threatening interaction when taken with Thalidomid... |
DB01042 | DB01101 | 1,307 | 60 | [
"DDInter1144",
"DDInter285"
] | Melphalan | Capecitabine | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Moderate | 1 | [
[
[
1307,
24,
60
]
],
[
[
1307,
5,
11579
],
[
11579,
44,
60
]
],
[
[
1307,
21,
28757
],
[
28757,
60,
60
]
],
[
[
1307,
23,
872
],
[
872,
... | [
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
]
],
[
[
"Melphalan",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is trea... | Melphalan (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Capecitabine (Compound)
Melphalan (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Capecitabine (Compound)
Melphalan may cause a minor interaction that can limit clinical effects when taken wi... |
DB00515 | DB14443 | 589 | 987 | [
"DDInter387",
"DDInter1931"
] | Cisplatin | Vibrio cholerae CVD 103-HgR strain live antigen | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
589,
24,
987
]
],
[
[
589,
24,
1480
],
[
1480,
24,
987
]
],
[
[
589,
63,
141
],
[
141,
24,
987
]
],
[
[
589,
64,
581
],
[
581,
2... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Cisplatin may cause a moderate interaction that could exacerbate diseases when t... |
DB00095 | DB14409 | 66 | 1,129 | [
"DDInter623",
"DDInter867"
] | Efalizumab | Human adenovirus e serotype 4 strain cl-68578 antigen | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
66,
24,
1129
]
],
[
[
66,
63,
1057
],
[
1057,
24,
1129
]
],
[
[
66,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
66,
25,
1259
],
[
1259,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wi... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Efalizumab may cause a moderate interaction that could exacerbate dis... |
DB00519 | DB09122 | 1,638 | 1,613 | [
"DDInter1843",
"DDInter1409"
] | Trandolapril | Peginterferon beta-1a | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1638,
24,
1613
]
],
[
[
1638,
24,
1274
],
[
1274,
24,
1613
]
],
[
[
1638,
24,
1383
],
[
1383,
63,
1613
]
],
[
[
1638,
63,
1560
],
[
15... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen... | Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with So... |
DB11130 | DB11732 | 407 | 1,097 | [
"DDInter1344",
"DDInter1027"
] | Opium | Lasmiditan | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
407,
24,
1097
]
],
[
[
407,
63,
701
],
[
701,
24,
1097
]
],
[
[
407,
24,
1609
],
[
1609,
24,
1097
]
],
[
[
407,
64,
593
],
[
593,
... | [
[
[
"Opium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Opium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
"Clema... | Opium may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Opium may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pentoxyverine... |
DB00880 | DB01362 | 359 | 497 | [
"DDInter360",
"DDInter960"
] | Chlorothiazide | Iohexol | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Moderate | 1 | [
[
[
359,
24,
497
]
],
[
[
359,
24,
258
],
[
258,
40,
497
]
],
[
[
359,
21,
28681
],
[
28681,
60,
497
]
],
[
[
359,
40,
674
],
[
674,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
],
... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Chlorothiazide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Chlorothiazide (Compound) rese... |
DB00371 | DB00662 | 1,050 | 717 | [
"DDInter1154",
"DDInter1873"
] | Meprobamate | Trimethobenzamide | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
1050,
24,
717
]
],
[
[
1050,
21,
28762
],
[
28762,
60,
717
]
],
[
[
1050,
63,
1594
],
[
1594,
24,
717
]
],
[
[
1050,
24,
13
],
[
13,
... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Meprobamate",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) ... | Meprobamate (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Trimethobenzamide (Compound)
Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00488 | DB10583 | 196 | 949 | [
"DDInter57",
"DDInter415"
] | Altretamine | Clostridium tetani toxoid antigen (formaldehyde inactivated) | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
196,
24,
949
]
],
[
[
196,
25,
1377
],
[
1377,
24,
949
]
],
[
[
196,
63,
58
],
[
58,
24,
949
]
],
[
[
196,
25,
1259
],
[
1259,
6... | [
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Altretamine",
"{u} may lead to a major life threatening interaction when taken with {v}... | Altretamine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Altretamine may cause a moderate interaction that could exacerbate disease... |
DB08880 | DB12500 | 1,510 | 283 | [
"DDInter1771",
"DDInter714"
] | Teriflunomide | Fedratinib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1510,
25,
283
]
],
[
[
1510,
24,
466
],
[
466,
62,
283
]
],
[
[
1510,
25,
351
],
[
351,
23,
283
]
],
[
[
1510,
64,
1593
],
[
1593,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Da... | Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Teriflunomide may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib ma... |
DB00063 | DB00939 | 366 | 1,338 | [
"DDInter659",
"DDInter1135"
] | Eptifibatide | Meclofenamic acid | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
366,
24,
1338
]
],
[
[
366,
24,
1479
],
[
1479,
63,
1338
]
],
[
[
366,
25,
1347
],
[
1347,
24,
1338
]
],
[
[
366,
64,
1271
],
[
1271,
... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic ... | Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Eptifibatide may lead to a major life threatening interaction when taken with Clopi... |
DB00218 | DB09154 | 1,176 | 1,475 | [
"DDInter1247",
"DDInter1686"
] | Moxifloxacin | Sodium citrate | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Moderate | 1 | [
[
[
1176,
24,
1475
]
],
[
[
1176,
24,
355
],
[
355,
23,
1475
]
],
[
[
1176,
25,
1411
],
[
1411,
23,
1475
]
],
[
[
1176,
1,
1467
],
[
1467,... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium citrate"
]
],
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
],
... | Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Moxifloxacin may lead to a major life threatening interaction when taken with Tolbutamide and Tolbutamide may ... |
DB00399 | DB00631 | 963 | 372 | [
"DDInter1968",
"DDInter405"
] | Zoledronic acid | Clofarabine | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
963,
24,
372
]
],
[
[
963,
21,
29122
],
[
29122,
60,
372
]
],
[
[
963,
24,
1441
],
[
1441,
24,
372
]
],
[
[
963,
24,
361
],
[
361,
... | [
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Zoledronic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Mediastinal disorder"
],
[
"Mediastinal disorder",... | Zoledronic acid (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Clofarabine (Compound)
Zoledronic acid may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin may cause a moderate interaction that could exacerbate... |
DB00630 | DB14520 | 1,485 | 1,229 | [
"DDInter42",
"DDInter1785"
] | Alendronic acid | Tetraferric tricitrate decahydrate | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease. Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2014. | Moderate | 1 | [
[
[
1485,
24,
1229
]
],
[
[
1485,
1,
1008
],
[
1008,
24,
1229
]
],
[
[
1485,
1,
1008
],
[
1008,
40,
1199
],
[
1199,
24,
1229
]
],
[
[
1485... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetraferric tricitrate decahydrate"
]
],
[
[
"Alendronic acid",
"{u} (Compound) resembles {v} (Compound)",
"Risedronic acid"
],
[
"Rise... | Alendronic acid (Compound) resembles Risedronic acid (Compound) and Risedronic acid may cause a moderate interaction that could exacerbate diseases when taken with Tetraferric tricitrate decahydrate
Alendronic acid (Compound) resembles Risedronic acid (Compound) and Risedronic acid (Compound) resembles Ibandronate (Com... |
DB00290 | DB00987 | 329 | 1,224 | [
"DDInter219",
"DDInter461"
] | Bleomycin | Cytarabine (liposomal) | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
329,
24,
1224
]
],
[
[
329,
5,
11555
],
[
11555,
44,
1224
]
],
[
[
329,
6,
7335
],
[
7335,
46,
1224
]
],
[
[
329,
23,
872
],
[
872,
... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Bleomycin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease)... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Bleomycin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Cytarabine (Compound)
Bleomycin (Compound) binds LIG1 (Gene) and LIG1 (Gene) is upregulated by Cytarabine (Compound... |
DB01220 | DB06595 | 1,088 | 1,491 | [
"DDInter1593",
"DDInter1214"
] | Rifaximin | Midostaurin | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1088,
24,
1491
]
],
[
[
1088,
24,
1662
],
[
1662,
63,
1491
]
],
[
[
1088,
40,
690
],
[
690,
24,
1491
]
],
[
[
1088,
63,
79
],
[
79,
... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
],
... | Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Rifaximin (Compound) resembles Rifabutin (Compound) and Rifabutin may cause a moderate interaction... |
DB00445 | DB06212 | 322 | 165 | [
"DDInter655",
"DDInter1833"
] | Epirubicin | Tolvaptan | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
322,
24,
165
]
],
[
[
322,
24,
522
],
[
522,
1,
165
]
],
[
[
322,
21,
28981
],
[
28981,
60,
165
]
],
[
[
322,
24,
267
],
[
267,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast (Compound) resembles Tolvaptan (Compound)
Epirubicin (Compound) causes Renal impairment (Side Effect) and Renal impairment (Side Effect) is caused by Tolvaptan (Compound)
Epirubicin may cause a moderat... |
DB00934 | DB08871 | 413 | 36 | [
"DDInter1124",
"DDInter666"
] | Maprotiline | Eribulin | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
413,
24,
36
]
],
[
[
413,
18,
16974
],
[
16974,
45,
36
]
],
[
[
413,
63,
1424
],
[
1424,
24,
36
]
],
[
[
413,
24,
820
],
[
820,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Maprotiline",
"{u} (Compound) downregulates {v} (Gene)",
"TUBB6"
],
[
"TUBB6",
"{u} (Gene) is bound by {v} (Compo... | Maprotiline (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Eribulin (Compound)
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Maprotiline may caus... |
DB06206 | DB06228 | 1,268 | 792 | [
"DDInter1719",
"DDInter1609"
] | Sugammadex | Rivaroxaban | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1268,
24,
792
]
],
[
[
1268,
24,
802
],
[
802,
64,
792
]
],
[
[
1268,
63,
291
],
[
291,
25,
792
]
],
[
[
1268,
24,
802
],
[
802,
... | [
[
[
"Sugammadex",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Sugammadex",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
],
[
... | Sugammadex may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin and Tinzaparin may lead to a major life threatening interaction when taken with Rivaroxaban
Sugammadex may cause a moderate interaction that could exacerbate diseases when taken with Argatroban and Argatroban may lead ... |
DB00853 | DB01041 | 1,686 | 770 | [
"DDInter1762",
"DDInter1789"
] | Temozolomide | Thalidomide | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
1686,
25,
770
]
],
[
[
1686,
21,
28784
],
[
28784,
60,
770
]
],
[
[
1686,
24,
4
],
[
4,
63,
770
]
],
[
[
1686,
23,
739
],
[
739,
... | [
[
[
"Temozolomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Temozolomide",
"{u} (Compound) causes {v} (Side Effect)",
"Thrombocytopenia"
],
[
"Thrombocytopenia",
"{u} (Side Effect) is ... | Temozolomide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Thalidomide (Compound)
Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that ... |
DB00934 | DB12245 | 413 | 823 | [
"DDInter1124",
"DDInter1863"
] | Maprotiline | Triclabendazole | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
413,
24,
823
]
],
[
[
413,
62,
112
],
[
112,
23,
823
]
],
[
[
413,
63,
1010
],
[
1010,
24,
823
]
],
[
[
413,
64,
1494
],
[
1494,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Maprotiline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Maprotiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine a... |
DB08899 | DB09073 | 129 | 951 | [
"DDInter649",
"DDInter1379"
] | Enzalutamide | Palbociclib | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
129,
25,
951
]
],
[
[
129,
25,
907
],
[
907,
62,
951
]
],
[
[
129,
64,
318
],
[
318,
23,
951
]
],
[
[
129,
62,
271
],
[
271,
23,... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doravirine"
],
[
"Doravirine",
"... | Enzalutamide may lead to a major life threatening interaction when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Enzalutamide may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor ... |
DB00398 | DB00563 | 79 | 663 | [
"DDInter1702",
"DDInter1174"
] | Sorafenib | Methotrexate | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
79,
24,
663
]
],
[
[
79,
6,
4973
],
[
4973,
45,
663
]
],
[
[
79,
18,
8569
],
[
8569,
45,
663
]
],
[
[
79,
7,
1720
],
[
1720,
46,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Sorafenib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Sorafenib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound)
Sorafenib (Compound) downregulates TYMS (Gene) and TYMS (Gene) is bound by Methotrexate (Compound)
Sorafenib (Compound) upregulates RELB (Gene) and RELB (Gene) is upregulated by Methotrexate (Compound)
Sorafenib (Compound) down... |
DB00818 | DB08871 | 898 | 36 | [
"DDInter1538",
"DDInter666"
] | Propofol | Eribulin | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
898,
24,
36
]
],
[
[
898,
63,
1424
],
[
1424,
24,
36
]
],
[
[
898,
24,
820
],
[
820,
24,
36
]
],
[
[
898,
24,
28
],
[
28,
63,
... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
"Quin... | Propofol may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Propofol may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may c... |
DB00719 | DB08883 | 1,219 | 1,597 | [
"DDInter149",
"DDInter1428"
] | Azatadine | Perampanel | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
1219,
24,
1597
]
],
[
[
1219,
24,
100
],
[
100,
24,
1597
]
],
[
[
1219,
40,
830
],
[
830,
24,
1597
]
],
[
[
1219,
63,
128
],
[
128,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],
[... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Perampanel
Azatadine (Compound) resembles Phenindamine (Compound) and Phenindamine may cause a moderate interactio... |
DB00092 | DB08904 | 58 | 375 | [
"DDInter40",
"DDInter342"
] | Alefacept | Certolizumab pegol | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
58,
24,
375
]
],
[
[
58,
23,
1461
],
[
1461,
23,
375
]
],
[
[
58,
23,
1193
],
[
1193,
62,
375
]
],
[
[
58,
24,
704
],
[
704,
24,... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Alefacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc... |
DB01259 | DB04855 | 392 | 540 | [
"DDInter1024",
"DDInter602"
] | Lapatinib | Dronedarone | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
392,
25,
540
]
],
[
[
392,
64,
347
],
[
347,
40,
540
]
],
[
[
392,
6,
8374
],
[
8374,
45,
540
]
],
[
[
392,
21,
28883
],
[
28883,
... | [
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} (Com... | Lapatinib may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Dronedarone (Compound)
Lapatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound)
Lapatinib (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Eff... |
DB00903 | DB09156 | 1,680 | 777 | [
"DDInter686",
"DDInter964"
] | Etacrynic acid | Iopromide | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
1680,
24,
777
]
],
[
[
1680,
63,
1648
],
[
1648,
24,
777
]
],
[
[
1680,
63,
1512
],
[
1512,
25,
777
]
],
[
[
1680,
64,
1132
],
[
1132,... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac a... |
DB01101 | DB01208 | 60 | 945 | [
"DDInter285",
"DDInter1705"
] | Capecitabine | Sparfloxacin | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
60,
23,
945
]
],
[
[
60,
62,
739
],
[
739,
1,
945
]
],
[
[
60,
23,
1539
],
[
1539,
1,
945
]
],
[
[
60,
21,
28787
],
[
28787,
60,... | [
[
[
"Capecitabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Capecitabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
... | Capecitabine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Capecitabine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) resembles Sparfloxacin (Comp... |
DB09054 | DB09128 | 384 | 1,241 | [
"DDInter905",
"DDInter231"
] | Idelalisib | Brexpiprazole | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Major | 2 | [
[
[
384,
25,
1241
]
],
[
[
384,
63,
761
],
[
761,
24,
1241
]
],
[
[
384,
64,
129
],
[
129,
24,
1241
]
],
[
[
384,
62,
222
],
[
222,
... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
],
[
"Saxagl... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Idelalisib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide m... |
DB00333 | DB00816 | 576 | 1,674 | [
"DDInter1166",
"DDInter1346"
] | Methadone | Orciprenaline | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Major | 2 | [
[
[
576,
25,
1674
]
],
[
[
576,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
576,
25,
1220
],
[
1220,
62,
1674
]
],
[
[
576,
40,
1164
],
[
1164... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Orciprenaline"
]
],
[
[
"Methadone",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is caused by {v} (Com... | Methadone (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Methadone may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Orciprenaline
Met... |
DB00030 | DB00367 | 1,685 | 566 | [
"DDInter934",
"DDInter1061"
] | Insulin human | Levonorgestrel | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Moderate | 1 | [
[
[
1685,
24,
566
]
],
[
[
1685,
24,
1336
],
[
1336,
40,
566
]
],
[
[
1685,
24,
1197
],
[
1197,
1,
566
]
],
[
[
1685,
24,
1130
],
[
1130,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etonogestrel"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Etonogestrel and Etonogestrel (Compound) resembles Levonorgestrel (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) resembles ... |
DB00372 | DB01276 | 999 | 123 | [
"DDInter1793",
"DDInter706"
] | Thiethylperazine | Exenatide | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
999,
24,
123
]
],
[
[
999,
63,
867
],
[
867,
24,
123
]
],
[
[
999,
24,
443
],
[
443,
24,
123
]
],
[
[
999,
24,
154
],
[
154,
63,... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olanzapine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Spironolac... |
DB00950 | DB14740 | 1,413 | 771 | [
"DDInter732",
"DDInter881"
] | Fexofenadine | Hyaluronidase | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
1413,
23,
771
]
],
[
[
1413,
1,
1242
],
[
1242,
23,
771
]
],
[
[
1413,
6,
12523
],
[
12523,
45,
849
],
[
849,
23,
771
]
],
[
[
1413,
... | [
[
[
"Fexofenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Fexofenadine",
"{u} (Compound) resembles {v} (Compound)",
"Cetirizine"
],
[
"Cetirizine",
"{u} may cause a mi... | Fexofenadine (Compound) resembles Cetirizine (Compound) and Cetirizine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Fexofenadine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound) and Mepyramine may cause a minor interaction that can limit c... |
DB00450 | DB12245 | 78 | 823 | [
"DDInter603",
"DDInter1863"
] | Droperidol | Triclabendazole | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Major | 2 | [
[
[
78,
25,
823
]
],
[
[
78,
23,
112
],
[
112,
23,
823
]
],
[
[
78,
64,
1010
],
[
1010,
24,
823
]
],
[
[
78,
24,
28
],
[
28,
24,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triclabendazole"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Droperidol may lead to a major life threatening interaction when taken with Mefloquine and Mefloquine may... |
DB00443 | DB00774 | 251 | 1,577 | [
"DDInter195",
"DDInter889"
] | Betamethasone | Hydroflumethiazide | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Moderate | 1 | [
[
[
251,
24,
1577
]
],
[
[
251,
24,
359
],
[
359,
40,
1577
]
],
[
[
251,
63,
323
],
[
323,
40,
1577
]
],
[
[
251,
24,
504
],
[
504,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazid... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide (Co... |
DB06186 | DB06754 | 1,439 | 707 | [
"DDInter969",
"DDInter471"
] | Ipilimumab | Danaparoid | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
1439,
25,
707
]
],
[
[
1439,
24,
637
],
[
637,
63,
707
]
],
[
[
1439,
63,
1560
],
[
1560,
24,
707
]
],
[
[
1439,
25,
235
],
[
235,
... | [
[
[
"Ipilimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
],
... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi and Asparaginase Erwinia chrysanthemi may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Ipilimumab may cause a moderate interaction that could exacerbate ... |
DB00774 | DB09104 | 1,577 | 286 | [
"DDInter889",
"DDInter1118"
] | Hydroflumethiazide | Magnesium hydroxide | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1577,
24,
286
]
],
[
[
1577,
24,
820
],
[
820,
23,
286
]
],
[
[
1577,
63,
999
],
[
999,
23,
286
]
],
[
[
1577,
24,
688
],
[
688,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Al... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00552 | DB05273 | 1,238 | 507 | [
"DDInter1425",
"DDInter1638"
] | Pentostatin | Samarium (153Sm) lexidronam | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
1238,
25,
507
]
],
[
[
1238,
24,
248
],
[
248,
24,
507
]
],
[
[
1238,
24,
270
],
[
270,
63,
507
]
],
[
[
1238,
1,
1083
],
[
1083,
... | [
[
[
"Pentostatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken... |
DB01344 | DB11921 | 1,231 | 1,019 | [
"DDInter1830",
"DDInter492"
] | Tolevamer | Deflazacort | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1231,
24,
1019
]
],
[
[
1231,
24,
1193
],
[
1193,
23,
1019
]
],
[
[
1231,
25,
286
],
[
286,
24,
1019
]
],
[
[
1231,
63,
544
],
[
544,
... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
],
[... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Tolevamer may lead to a major life threatening interaction when taken with Magnesium hydroxide and Magnesi... |
DB00515 | DB00900 | 589 | 45 | [
"DDInter387",
"DDInter544"
] | Cisplatin | Didanosine | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Moderate | 1 | [
[
[
589,
24,
45
]
],
[
[
589,
21,
28709
],
[
28709,
60,
45
]
],
[
[
589,
24,
36
],
[
36,
63,
45
]
],
[
[
589,
25,
1292
],
[
1292,
63... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
]
],
[
[
"Cisplatin",
"{u} (Compound) causes {v} (Side Effect)",
"Decreased appetite"
],
[
"Decreased appetite",
"{u} (Side... | Cisplatin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Didanosine (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00497 | DB01234 | 828 | 1,220 | [
"DDInter1366",
"DDInter513"
] | Oxycodone | Dexamethasone | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Major | 2 | [
[
[
828,
25,
1220
]
],
[
[
828,
6,
21998
],
[
21998,
45,
1220
]
],
[
[
828,
21,
28835
],
[
28835,
60,
1220
]
],
[
[
828,
24,
578
],
[
578,... | [
[
[
"Oxycodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
]
],
[
[
"Oxycodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by {v} (Compoun... | Oxycodone (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Dexamethasone (Compound)
Oxycodone (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Dexamethasone (Compound)
Oxycodone may cause a moderate interaction that could exacerbate diseases when... |
DB01069 | DB09043 | 401 | 135 | [
"DDInter1533",
"DDInter36"
] | Promethazine | Albiglutide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
401,
24,
135
]
],
[
[
401,
63,
1647
],
[
1647,
23,
135
]
],
[
[
401,
24,
519
],
[
519,
24,
135
]
],
[
[
401,
63,
323
],
[
323,
2... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Palip... |
DB00582 | DB09272 | 1,622 | 412 | [
"DDInter1946",
"DDInter632"
] | Voriconazole | Eluxadoline | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
1622,
24,
412
]
],
[
[
1622,
25,
543
],
[
543,
24,
412
]
],
[
[
1622,
23,
1413
],
[
1413,
24,
412
]
],
[
[
1622,
24,
1374
],
[
1374,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Loperamide"
],
[
"Loper... | Voriconazole may lead to a major life threatening interaction when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Fexofenadine and Fexofenadine may... |
DB00017 | DB00501 | 1,505 | 752 | [
"DDInter1636",
"DDInter380"
] | Salmon calcitonin | Cimetidine | Synthetic peptide, 32 residues long formulated as a nasal spray. | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
1505,
23,
752
]
],
[
[
1505,
23,
475
],
[
475,
24,
752
]
],
[
[
1505,
24,
789
],
[
789,
6,
10612
],
[
10612,
45,
752
]
],
[
[
1505,
... | [
[
[
"Salmon calcitonin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Salmon calcitonin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Morphine"
],
... | Salmon calcitonin may cause a minor interaction that can limit clinical effects when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Salmon calcitonin may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and... |
DB00197 | DB01324 | 1,324 | 178 | [
"DDInter1881",
"DDInter1490"
] | Troglitazone | Polythiazide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
1324,
24,
178
]
],
[
[
1324,
24,
504
],
[
504,
40,
178
]
],
[
[
1324,
24,
126
],
[
126,
23,
178
]
],
[
[
1324,
24,
761
],
[
761,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor inter... |
DB00334 | DB00372 | 867 | 999 | [
"DDInter1326",
"DDInter1793"
] | Olanzapine | Thiethylperazine | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
867,
24,
999
]
],
[
[
867,
24,
1614
],
[
1614,
63,
999
]
],
[
[
867,
63,
352
],
[
352,
24,
999
]
],
[
[
867,
1,
695
],
[
695,
24... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospi... |
DB00350 | DB00726 | 1,214 | 1,164 | [
"DDInter1226",
"DDInter1876"
] | Minoxidil | Trimipramine | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
1214,
24,
1164
]
],
[
[
1214,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
1214,
63,
576
],
[
576,
40,
1164
]
],
[
[
1214,
24,
999
],
[
999,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Trimipramine (Compou... |
DB00912 | DB01021 | 473 | 674 | [
"DDInter1581",
"DDInter1861"
] | Repaglinide | Trichlormethiazide | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
473,
24,
674
]
],
[
[
473,
63,
1014
],
[
1014,
40,
674
]
],
[
[
473,
24,
178
],
[
178,
1,
674
]
],
[
[
473,
24,
455
],
[
455,
24... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Tric... |
DB00773 | DB12887 | 896 | 1,598 | [
"DDInter702",
"DDInter1750"
] | Etoposide | Tazemetostat | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
896,
24,
1598
]
],
[
[
896,
63,
168
],
[
168,
23,
1598
]
],
[
[
896,
24,
310
],
[
310,
24,
1598
]
],
[
[
896,
63,
134
],
[
134,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Tazemetostat
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazit... |
DB01041 | DB01044 | 770 | 246 | [
"DDInter1789",
"DDInter809"
] | Thalidomide | Gatifloxacin | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Moderate | 1 | [
[
[
770,
24,
246
]
],
[
[
770,
63,
739
],
[
739,
1,
246
]
],
[
[
770,
24,
945
],
[
945,
40,
246
]
],
[
[
770,
21,
28868
],
[
28868,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Gatifloxac... |
DB00978 | DB01142 | 739 | 1,264 | [
"DDInter1084",
"DDInter593"
] | Lomefloxacin | Doxepin | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
739,
24,
1264
]
],
[
[
739,
24,
401
],
[
401,
24,
1264
]
],
[
[
739,
6,
7950
],
[
7950,
45,
1264
]
],
[
[
739,
21,
28898
],
[
28898,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Lomefloxacin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Doxepin (Compound)
Lomefloxacin (Co... |
DB01235 | DB06273 | 1,191 | 980 | [
"DDInter1054",
"DDInter1824"
] | Levodopa | Tocilizumab | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1191,
24,
980
]
],
[
[
1191,
24,
309
],
[
309,
24,
980
]
],
[
[
1191,
63,
973
],
[
973,
24,
980
]
],
[
[
1191,
24,
850
],
[
850,
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclita... |
DB00401 | DB11834 | 84 | 1,303 | [
"DDInter1298",
"DDInter849"
] | Nisoldipine | Guselkumab | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
84,
24,
1303
]
],
[
[
84,
63,
58
],
[
58,
24,
1303
]
],
[
[
84,
24,
259
],
[
259,
24,
1303
]
],
[
[
84,
1,
1081
],
[
1081,
24,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilona... |
DB00328 | DB00586 | 831 | 1,512 | [
"DDInter921",
"DDInter537"
] | Indomethacin | Diclofenac | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
831,
24,
1512
]
],
[
[
831,
40,
1263
],
[
1263,
63,
1512
]
],
[
[
831,
6,
9320
],
[
9320,
45,
1512
]
],
[
[
831,
10,
11610
],
[
11610,... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Indomethacin",
"{u} (Compound) resembles {v} (Compound)",
"Bromfenac"
],
[
"Bromfenac",
"{u} may cause a moder... | Indomethacin (Compound) resembles Bromfenac (Compound) and Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Indomethacin (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Diclofenac (Compound)
Indomethacin (Compound) palliates migraine (Disease) and migraine ... |
DB00467 | DB01067 | 1,467 | 959 | [
"DDInter644",
"DDInter826"
] | Enoxacin | Glipizide | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Major | 2 | [
[
[
1467,
25,
959
]
],
[
[
1467,
64,
245
],
[
245,
40,
959
]
],
[
[
1467,
25,
1411
],
[
1411,
1,
959
]
],
[
[
1467,
24,
1475
],
[
1475,
... | [
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glipizide"
]
],
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glimepiride"
],
[
"Glimepiride",
"{u} (Com... | Enoxacin may lead to a major life threatening interaction when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Enoxacin may lead to a major life threatening interaction when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
Enoxacin may cause a moderate in... |
DB00398 | DB01254 | 79 | 1,213 | [
"DDInter1702",
"DDInter484"
] | Sorafenib | Dasatinib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
79,
24,
1213
]
],
[
[
79,
6,
17404
],
[
17404,
45,
1213
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],
[
[
79,
7,
3361
],
[
3361,
46,
1213
]
],
[
[
79,
18,
1986
],
[
1986,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Sorafenib",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Sorafenib (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Sorafenib (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Dasatinib (Compound)
Sorafenib (Compound) downregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Dasatinib (Compound)
Sorafenib (Compound) d... |
DB00759 | DB01060 | 1,620 | 319 | [
"DDInter1783",
"DDInter83"
] | Tetracycline | Amoxicillin | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | Moderate | 1 | [
[
[
1620,
24,
319
]
],
[
[
1620,
63,
1249
],
[
1249,
40,
319
]
],
[
[
1620,
24,
950
],
[
950,
1,
319
]
],
[
[
1620,
63,
703
],
[
703,
... | [
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxicillin"
]
],
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
... | Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin (Compound) resembles Amoxicillin (Compound)
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Cloxacillin and Cloxacillin (Compound) resembles Amoxicillin (Comp... |
DB00687 | DB11652 | 870 | 1,155 | [
"DDInter747",
"DDInter1891"
] | Fludrocortisone | Tucatinib | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
870,
24,
1155
]
],
[
[
870,
63,
1101
],
[
1101,
23,
1155
]
],
[
[
870,
23,
659
],
[
659,
24,
1155
]
],
[
[
870,
24,
609
],
[
609,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Vilanterol and V... |
DB00214 | DB00470 | 1,028 | 530 | [
"DDInter1836",
"DDInter601"
] | Torasemide | Dronabinol | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
1028,
24,
530
]
],
[
[
1028,
24,
1614
],
[
1614,
40,
530
]
],
[
[
1028,
6,
6017
],
[
6017,
45,
530
]
],
[
[
1028,
21,
28921
],
[
28921... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Torasemide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dronabinol (Compound)
Torasemide (Compound) causes Dizziness (Side Effect) and Dizziness (Si... |
DB00812 | DB06228 | 998 | 792 | [
"DDInter1451",
"DDInter1609"
] | Phenylbutazone | Rivaroxaban | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
998,
25,
792
]
],
[
[
998,
6,
8374
],
[
8374,
45,
792
]
],
[
[
998,
40,
307
],
[
307,
23,
792
]
],
[
[
998,
63,
79
],
[
79,
24,
... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Phenylbutazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rivaroxaban (Compound)
Phenylbutazone (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Phenylbutazone may cause a moderate interaction that could e... |
DB01165 | DB01177 | 1,539 | 77 | [
"DDInter1325",
"DDInter904"
] | Ofloxacin | Idarubicin | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1539,
24,
77
]
],
[
[
1539,
6,
10417
],
[
10417,
45,
77
]
],
[
[
1539,
18,
10838
],
[
10838,
46,
77
]
],
[
[
1539,
21,
28931
],
[
2893... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Ofloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compound)",
... | Ofloxacin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Idarubicin (Compound)
Ofloxacin (Compound) downregulates HTATSF1 (Gene) and HTATSF1 (Gene) is upregulated by Idarubicin (Compound)
Ofloxacin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)
O... |
DB00078 | DB08868 | 1,172 | 1,011 | [
"DDInter898",
"DDInter737"
] | Ibritumomab tiuxetan | Fingolimod | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1172,
25,
1011
]
],
[
[
1172,
24,
578
],
[
578,
23,
1011
]
],
[
[
1172,
24,
748
],
[
748,
63,
1011
]
],
[
[
1172,
24,
1136
],
[
1136,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Ant... |
DB01246 | DB09564 | 820 | 1,296 | [
"DDInter45",
"DDInter930"
] | Alimemazine | Insulin degludec | A phenothiazine derivative that is used as an antipruritic. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
820,
24,
1296
]
],
[
[
820,
63,
274
],
[
274,
23,
1296
]
],
[
[
820,
64,
1621
],
[
1621,
23,
1296
]
],
[
[
820,
64,
17
],
[
17,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Alimemazine may lead to a major life threatening interaction when taken with Potassium chloride and Pot... |
DB01005 | DB05679 | 995 | 1,683 | [
"DDInter894",
"DDInter1907"
] | Hydroxyurea | Ustekinumab | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
995,
24,
1683
]
],
[
[
995,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
995,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
995,
63,
1001
],
[
1001,
... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib ... |
DB09052 | DB10429 | 250 | 200 | [
"DDInter220",
"DDInter282"
] | Blinatumomab | Candida albicans | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
250,
24,
200
]
],
[
[
250,
63,
1683
],
[
1683,
24,
200
]
],
[
[
250,
64,
976
],
[
976,
24,
200
]
],
[
[
250,
24,
738
],
[
738,
6... | [
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
... | Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Blinatumomab may lead to a major life threatening interaction when taken with Tofacitinib and Tofaciti... |
DB00468 | DB06616 | 1,424 | 594 | [
"DDInter1557",
"DDInter224"
] | Quinine | Bosutinib | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1424,
24,
594
]
],
[
[
1424,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1424,
21,
29231
],
[
29231,
60,
594
]
],
[
[
1424,
23,
112
],
[
112,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Quinine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Quinine (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Bosutinib (Compound)
Quinine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and ... |
DB00218 | DB05294 | 1,176 | 1,069 | [
"DDInter1247",
"DDInter1917"
] | Moxifloxacin | Vandetanib | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1176,
25,
1069
]
],
[
[
1176,
21,
29343
],
[
29343,
60,
1069
]
],
[
[
1176,
23,
112
],
[
112,
23,
1069
]
],
[
[
1176,
24,
659
],
[
659... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Blood creatinine increased"
],
[
"Blood creatinine increased",
"{u... | Moxifloxacin (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by Vandetanib (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit ... |
DB00902 | DB01320 | 104 | 651 | [
"DDInter1168",
"DDInter783"
] | Methdilazine | Fosphenytoin | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
104,
24,
651
]
],
[
[
104,
63,
362
],
[
362,
1,
651
]
],
[
[
104,
24,
5
],
[
5,
63,
651
]
],
[
[
104,
24,
1264
],
[
1264,
24,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide and Liraglutide may cause a moderate interaction that... |
DB01359 | DB11348 | 729 | 1,065 | [
"DDInter1417",
"DDInter279"
] | Penbutolol | Calcium Phosphate | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
729,
24,
1065
]
],
[
[
729,
40,
461
],
[
461,
24,
1065
]
],
[
[
729,
62,
1152
],
[
1152,
24,
1065
]
],
[
[
729,
1,
699
],
[
699,
... | [
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Penbutolol",
"{u} (Compound) resembles {v} (Compound)",
"Timolol"
],
[
"Timolol",
"{u} may cause a modera... | Penbutolol (Compound) resembles Timolol (Compound) and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Penbutolol may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine may cause a moderate interaction that co... |
DB00196 | DB00344 | 600 | 1,302 | [
"DDInter743",
"DDInter1543"
] | Fluconazole | Protriptyline | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Moderate | 1 | [
[
[
600,
24,
1302
]
],
[
[
600,
24,
413
],
[
413,
1,
1302
]
],
[
[
600,
6,
4973
],
[
4973,
45,
1302
]
],
[
[
600,
18,
6718
],
[
6718,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
],
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Protriptyline (Compound)
Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Protriptyline (Compound)
Fluconazole (Compound) downregulates USP22 (Gene) and USP2... |
DB05015 | DB12147 | 1,077 | 241 | [
"DDInter174",
"DDInter661"
] | Belinostat | Erdafitinib | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
1077,
24,
241
]
],
[
[
1077,
24,
384
],
[
384,
24,
241
]
],
[
[
1077,
63,
478
],
[
478,
24,
241
]
],
[
[
1077,
24,
1619
],
[
1619,
... | [
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Niloti... |
DB00083 | DB00427 | 677 | 1,233 | [
"DDInter225",
"DDInter1879"
] | Botulinum toxin type A | Triprolidine | In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperf... | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
677,
24,
1233
]
],
[
[
677,
24,
262
],
[
262,
63,
1233
]
],
[
[
677,
24,
999
],
[
999,
24,
1233
]
],
[
[
677,
24,
262
],
[
262,
... | [
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"C... | Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB01039 | DB01124 | 535 | 1,411 | [
"DDInter718",
"DDInter1828"
] | Fenofibrate | Tolbutamide | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
535,
24,
1411
]
],
[
[
535,
24,
959
],
[
959,
40,
1411
]
],
[
[
535,
63,
245
],
[
245,
40,
1411
]
],
[
[
535,
6,
3486
],
[
3486,
... | [
[
[
"Fenofibrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Fenofibrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Fenofibrate may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Fenofibrate may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compou... |
DB06335 | DB09048 | 761 | 555 | [
"DDInter1646",
"DDInter1284"
] | Saxagliptin | Netupitant | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
761,
24,
555
]
],
[
[
761,
64,
1101
],
[
1101,
23,
555
]
],
[
[
761,
24,
283
],
[
283,
62,
555
]
],
[
[
761,
63,
473
],
[
473,
2... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Saxagliptin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Saxagliptin may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause ... |
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