drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01115 | DB01259 | 336 | 392 | [
"DDInter1291",
"DDInter1024"
] | Nifedipine | Lapatinib | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
336,
24,
392
]
],
[
[
336,
6,
4973
],
[
4973,
45,
392
]
],
[
[
336,
18,
3833
],
[
3833,
57,
392
]
],
[
[
336,
21,
28688
],
[
28688,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Nifedipine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nifedipine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Nifedipine (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Lapatinib (Compound)
Nifedipine (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Nifedip... |
DB00999 | DB01169 | 504 | 57 | [
"DDInter883",
"DDInter120"
] | Hydrochlorothiazide | Arsenic trioxide | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
504,
25,
57
]
],
[
[
504,
24,
603
],
[
603,
63,
57
]
],
[
[
504,
63,
480
],
[
480,
24,
57
]
],
[
[
504,
24,
688
],
[
688,
24,
... | [
[
[
"Hydrochlorothiazide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate and Magnesium citrate may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases... |
DB00254 | DB00696 | 964 | 826 | [
"DDInter598",
"DDInter665"
] | Doxycycline | Ergotamine | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Moderate | 1 | [
[
[
964,
24,
826
]
],
[
[
964,
24,
588
],
[
588,
1,
826
]
],
[
[
964,
63,
1131
],
[
1131,
40,
826
]
],
[
[
964,
6,
8374
],
[
8374,
4... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergotamine"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylergometrine"
],... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Methylergometrine and Methylergometrine (Compound) resembles Ergotamine (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Methysergide and Methysergide (Compound) resembles Er... |
DB01110 | DB01410 | 86 | 423 | [
"DDInter1209",
"DDInter375"
] | Miconazole | Ciclesonide | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Moderate | 1 | [
[
[
86,
24,
423
]
],
[
[
86,
63,
1351
],
[
1351,
40,
423
]
],
[
[
86,
24,
617
],
[
617,
40,
423
]
],
[
[
86,
6,
8374
],
[
8374,
45,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ciclesonide"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flunisolide"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Ciclesonide (Compound)
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Ciclesonide (Compou... |
DB06810 | DB11703 | 397 | 405 | [
"DDInter1484",
"DDInter9"
] | Plicamycin | Acalabrutinib | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
397,
25,
405
]
],
[
[
397,
63,
383
],
[
383,
24,
405
]
],
[
[
397,
24,
151
],
[
151,
63,
405
]
],
[
[
397,
24,
810
],
[
810,
24,... | [
[
[
"Plicamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Plicamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
... | Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Plicamycin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01042 | DB08826 | 1,307 | 1,292 | [
"DDInter1144",
"DDInter489"
] | Melphalan | Deferiprone | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1307,
25,
1292
]
],
[
[
1307,
21,
28759
],
[
28759,
60,
1292
]
],
[
[
1307,
23,
1193
],
[
1193,
63,
1292
]
],
[
[
1307,
63,
482
],
[
4... | [
[
[
"Melphalan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Melphalan",
"{u} (Compound) causes {v} (Side Effect)",
"Connective tissue disorder"
],
[
"Connective tissue disorder",
"{u} (Si... | Melphalan (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Deferiprone (Compound)
Melphalan may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a moderate interaction that could exac... |
DB01041 | DB05812 | 770 | 1,374 | [
"DDInter1789",
"DDInter8"
] | Thalidomide | Abiraterone | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
770,
24,
1374
]
],
[
[
770,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
770,
63,
112
],
[
112,
23,
1374
]
],
[
[
770,
24,
915
],
[
915,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Thalidomide",
"{u} (Compound) causes {v} (Side Effect)",
"Hypokalaemia"
],
[
"Hypokalaemia",
"{u} (Side Effect... | Thalidomide (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken... |
DB00381 | DB12500 | 376 | 283 | [
"DDInter79",
"DDInter714"
] | Amlodipine | Fedratinib | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
376,
24,
283
]
],
[
[
376,
23,
466
],
[
466,
62,
283
]
],
[
[
376,
24,
351
],
[
351,
23,
283
]
],
[
[
376,
24,
1419
],
[
1419,
2... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Amlodipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Amlodipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboci... |
DB09280 | DB15091 | 1,604 | 676 | [
"DDInter1101",
"DDInter1901"
] | Lumacaftor | Upadacitinib | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1604,
25,
676
]
],
[
[
1604,
25,
214
],
[
214,
24,
676
]
],
[
[
1604,
64,
655
],
[
655,
24,
676
]
],
[
[
1604,
63,
307
],
[
307,
... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
],
[
"Fostamatinib",
... | Lumacaftor may lead to a major life threatening interaction when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Lumacaftor may lead to a major life threatening interaction when taken with Etravirine and Etravirine may cause a moderat... |
DB06414 | DB11901 | 655 | 913 | [
"DDInter703",
"DDInter107"
] | Etravirine | Apalutamide | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
655,
25,
913
]
],
[
[
655,
63,
112
],
[
112,
23,
913
]
],
[
[
655,
63,
600
],
[
600,
24,
913
]
],
[
[
655,
24,
1320
],
[
1320,
6... | [
[
[
"Etravirine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metron... | Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and ... |
DB09098 | DB12240 | 98 | 110 | [
"DDInter1700",
"DDInter1485"
] | Somatrem | Polatuzumab vedotin | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
98,
24,
110
]
],
[
[
98,
63,
129
],
[
129,
23,
110
]
],
[
[
98,
63,
467
],
[
467,
24,
110
]
],
[
[
98,
24,
1480
],
[
1480,
24,
... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin an... |
DB01142 | DB01166 | 1,264 | 477 | [
"DDInter593",
"DDInter379"
] | Doxepin | Cilostazol | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1264,
24,
477
]
],
[
[
1264,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1264,
18,
9384
],
[
9384,
57,
477
]
],
[
[
1264,
21,
28658
],
[
28658... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Doxepin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Doxepin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Doxepin (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Cilostazol (Compound)
Doxepin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Cilostazol (Compound)
Doxepin may c... |
DB01227 | DB01362 | 1,301 | 497 | [
"DDInter1043",
"DDInter960"
] | Levacetylmethadol | Iohexol | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1301,
25,
497
]
],
[
[
1301,
40,
494
],
[
494,
24,
497
]
],
[
[
1301,
64,
530
],
[
530,
25,
497
]
],
[
[
1301,
25,
129
],
[
129,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Levacetylmethadol",
"{u} (Compound) resembles {v} (Compound)",
"Disopyramide"
],
[
"Disopyramide",
"{u} may cause a moderat... | Levacetylmethadol (Compound) resembles Disopyramide (Compound) and Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
Levacetylmethadol may lead to a major life threatening interaction when taken with Dronabinol and Dronabinol may lead to a major life threatening intera... |
DB00679 | DB00983 | 684 | 480 | [
"DDInter1796",
"DDInter776"
] | Thioridazine | Formoterol | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
684,
24,
480
]
],
[
[
684,
25,
1148
],
[
1148,
63,
480
]
],
[
[
684,
6,
6017
],
[
6017,
45,
480
]
],
[
[
684,
7,
3576
],
[
3576,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
],
[
"Isop... | Thioridazine may lead to a major life threatening interaction when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Thioridazine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Formoterol (Compound)
Thioridazine (Compound) u... |
DB01579 | DB06203 | 341 | 1,002 | [
"DDInter1439",
"DDInter51"
] | Phendimetrazine | Alogliptin | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
341,
24,
1002
]
],
[
[
341,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
341,
21,
28762
],
[
28762,
60,
1002
]
],
[
[
341,
63,
401
],
[
401,
... | [
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
... | Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Phendimetrazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Alogliptin (Compound)
Phendimetrazine may cause a modera... |
DB00279 | DB09263 | 1,152 | 1,436 | [
"DDInter1074",
"DDInter1399"
] | Liothyronine | Patiromer | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Moderate | 1 | [
[
[
1152,
24,
1436
]
],
[
[
1152,
24,
841
],
[
841,
63,
1436
]
],
[
[
1152,
24,
660
],
[
660,
24,
1436
]
],
[
[
1152,
63,
837
],
[
837,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patiromer"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhyd... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous and Calcium glubionate anhydrous may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Liothyronine may cause a moderate interaction that could exacerbate disease... |
DB00252 | DB08904 | 362 | 375 | [
"DDInter1460",
"DDInter342"
] | Phenytoin | Certolizumab pegol | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
362,
24,
375
]
],
[
[
362,
25,
1593
],
[
1593,
24,
375
]
],
[
[
362,
24,
303
],
[
303,
24,
375
]
],
[
[
362,
23,
608
],
[
608,
2... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Criz... | Phenytoin may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate an... |
DB00513 | DB11330 | 191 | 979 | [
"DDInter70",
"DDInter709"
] | Aminocaproic acid | Factor IX Complex (Human) | An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. | Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (St... | Major | 2 | [
[
[
191,
25,
979
]
],
[
[
191,
25,
350
],
[
350,
25,
979
]
],
[
[
191,
6,
6798
],
[
6798,
45,
335
],
[
335,
25,
979
]
],
[
[
191,
25... | [
[
[
"Aminocaproic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Factor IX Complex (Human)"
]
],
[
[
"Aminocaproic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
],
[
... | Aminocaproic acid may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib may lead to a major life threatening interaction when taken with Factor IX Complex (Human)
Aminocaproic acid (Compound) binds PLG (Gene) and PLG (Gene) is bound by Tranexamic acid (Compound) and Tranexamic aci... |
DB00461 | DB09122 | 598 | 1,613 | [
"DDInter1254",
"DDInter1409"
] | Nabumetone | Peginterferon beta-1a | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
598,
24,
1613
]
],
[
[
598,
24,
1274
],
[
1274,
24,
1613
]
],
[
[
598,
24,
1383
],
[
1383,
63,
1613
]
],
[
[
598,
25,
292
],
[
292,
... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Sodium... |
DB01255 | DB11901 | 633 | 913 | [
"DDInter1078",
"DDInter107"
] | Lisdexamfetamine | Apalutamide | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
633,
24,
913
]
],
[
[
633,
62,
112
],
[
112,
23,
913
]
],
[
[
633,
63,
600
],
[
600,
24,
913
]
],
[
[
633,
24,
28
],
[
28,
24,
... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Flucon... |
DB00595 | DB03754 | 1,545 | 1,400 | [
"DDInter1374",
"DDInter1883"
] | Oxytetracycline | Tromethamine | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th e... | Moderate | 1 | [
[
[
1545,
24,
1400
]
],
[
[
1545,
63,
663
],
[
663,
23,
1400
]
],
[
[
1545,
40,
964
],
[
964,
24,
1400
]
],
[
[
1545,
23,
1399
],
[
1399,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tromethamine"
]
],
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
... | Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Tromethamine
Oxytetracycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a moderate intera... |
DB00041 | DB01246 | 1,648 | 820 | [
"DDInter38",
"DDInter45"
] | Aldesleukin | Alimemazine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1648,
24,
820
]
],
[
[
1648,
24,
358
],
[
358,
24,
820
]
],
[
[
1648,
24,
104
],
[
104,
40,
820
]
],
[
[
1648,
24,
675
],
[
675,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine a... |
DB00619 | DB00717 | 1,419 | 1,197 | [
"DDInter909",
"DDInter1312"
] | Imatinib | Norethisterone | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Moderate | 1 | [
[
[
1419,
24,
1197
]
],
[
[
1419,
24,
890
],
[
890,
1,
1197
]
],
[
[
1419,
24,
984
],
[
984,
40,
1197
]
],
[
[
1419,
63,
989
],
[
989,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol (Compound) resembles Norethisterone (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Norethisterone (Compound)
Imat... |
DB00372 | DB08882 | 999 | 1,281 | [
"DDInter1793",
"DDInter1070"
] | Thiethylperazine | Linagliptin | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
999,
24,
1281
]
],
[
[
999,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
999,
24,
1529
],
[
1529,
24,
1281
]
],
[
[
999,
63,
73
],
[
73,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine may cause a moderate int... |
DB08889 | DB10315 | 350 | 1,137 | [
"DDInter299",
"DDInter1127"
] | Carfilzomib | Measles virus vaccine live attenuated | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
350,
25,
1137
]
],
[
[
350,
64,
581
],
[
581,
25,
1137
]
],
[
[
350,
24,
384
],
[
384,
25,
1137
]
],
[
[
350,
63,
1184
],
[
1184,
... | [
[
[
"Carfilzomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Carfilzomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Carfilzomib may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelali... |
DB01218 | DB08865 | 1,493 | 1,593 | [
"DDInter852",
"DDInter448"
] | Halofantrine | Crizotinib | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
1493,
25,
1593
]
],
[
[
1493,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1493,
7,
5998
],
[
5998,
46,
1593
]
],
[
[
1493,
18,
3023
],
[
3023... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Halofantrine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cri... | Halofantrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Halofantrine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Crizotinib (Compound)
Halofantrine (Compound) downregulates RUVBL1 (Gene) and RUVBL1 (Gene) is downregulated by Crizotinib (Compound)
Halofa... |
DB00845 | DB09268 | 1,490 | 1,662 | [
"DDInter406",
"DDInter1464"
] | Clofazimine | Picosulfuric acid | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1490,
24,
1662
]
],
[
[
1490,
24,
484
],
[
484,
63,
1662
]
],
[
[
1490,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
1490,
24,
1491
],
[
1491... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]... | Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Clofazimine may lead to a major life threatening interaction when taken with Cabozantinib and Cabozant... |
DB06717 | DB08816 | 875 | 578 | [
"DDInter778",
"DDInter1802"
] | Fosaprepitant | Ticagrelor | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
875,
24,
578
]
],
[
[
875,
21,
28646
],
[
28646,
60,
578
]
],
[
[
875,
25,
1135
],
[
1135,
62,
578
]
],
[
[
875,
40,
723
],
[
723,
... | [
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Fosaprepitant",
"{u} (Compound) causes {v} (Side Effect)",
"Unspecified disorder of skin and subcutaneous tissue"
],
[
... | Fosaprepitant (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Fosaprepitant may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a ... |
DB00650 | DB00754 | 1,147 | 157 | [
"DDInter1041",
"DDInter696"
] | Leucovorin | Ethotoin | Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharma... | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
1147,
24,
157
]
],
[
[
1147,
24,
759
],
[
759,
40,
157
]
],
[
[
1147,
24,
499
],
[
499,
1,
157
]
],
[
[
1147,
21,
28921
],
[
28921,
... | [
[
[
"Leucovorin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Leucovorin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Ethotoin (Compound)
Le... |
DB00675 | DB09122 | 888 | 1,613 | [
"DDInter1744",
"DDInter1409"
] | Tamoxifen | Peginterferon beta-1a | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
888,
24,
1613
]
],
[
[
888,
24,
671
],
[
671,
24,
1613
]
],
[
[
888,
63,
152
],
[
152,
24,
1613
]
],
[
[
888,
24,
1155
],
[
1155,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Bosentan a... |
DB00281 | DB01215 | 608 | 1,418 | [
"DDInter1066",
"DDInter677"
] | Lidocaine | Estazolam | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
608,
24,
1418
]
],
[
[
608,
24,
523
],
[
523,
1,
1418
]
],
[
[
608,
24,
1216
],
[
1216,
40,
1418
]
],
[
[
608,
63,
905
],
[
905,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
Lido... |
DB00342 | DB00539 | 1,181 | 11 | [
"DDInter1770",
"DDInter1837"
] | Terfenadine | Toremifene | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
1181,
25,
11
]
],
[
[
1181,
23,
1247
],
[
1247,
62,
11
]
],
[
[
1181,
25,
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],
[
723,
63,
11
]
],
[
[
1181,
24,
144
],
[
144,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Toremifene
Terfenadine may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant ... |
DB00358 | DB00834 | 1,010 | 932 | [
"DDInter1140",
"DDInter1215"
] | Mefloquine | Mifepristone | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
1010,
25,
932
]
],
[
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1010,
6,
4973
],
[
4973,
45,
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[
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1010,
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],
[
7669,
46,
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]
],
[
[
1010,
21,
28762
],
[
28762,... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Mifepri... | Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mifepristone (Compound)
Mefloquine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Mifepristone (Compound)
Mefloquine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Mefl... |
DB01619 | DB09118 | 830 | 1,580 | [
"DDInter1441",
"DDInter1711"
] | Phenindamine | Stiripentol | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
830,
24,
1580
]
],
[
[
830,
63,
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],
[
1532,
24,
1580
]
],
[
[
830,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
830,
1,
1219
],
[
1219,
... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine an... |
DB00975 | DB15035 | 1,317 | 503 | [
"DDInter573",
"DDInter1959"
] | Dipyridamole | Zanubrutinib | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1317,
25,
503
]
],
[
[
1317,
24,
222
],
[
222,
24,
503
]
],
[
[
1317,
63,
121
],
[
121,
24,
503
]
],
[
[
1317,
25,
39
],
[
39,
2... | [
[
[
"Dipyridamole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Dipyridamole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sib... | Dipyridamole may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Dipyridamole may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine ... |
DB01015 | DB06788 | 1,247 | 1,616 | [
"DDInter1724",
"DDInter864"
] | Sulfamethoxazole | Histrelin | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Minor | 0 | [
[
[
1247,
23,
1616
]
],
[
[
1247,
62,
112
],
[
112,
23,
1616
]
],
[
[
1247,
23,
1342
],
[
1342,
24,
1616
]
],
[
[
1247,
63,
1179
],
[
1179... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Histrelin"
]
],
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]... | Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin... |
DB00526 | DB10429 | 1,555 | 200 | [
"DDInter1355",
"DDInter282"
] | Oxaliplatin | Candida albicans | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1555,
24,
200
]
],
[
[
1555,
24,
1683
],
[
1683,
24,
200
]
],
[
[
1555,
25,
976
],
[
976,
24,
200
]
],
[
[
1555,
63,
168
],
[
168,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Oxaliplatin may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitini... |
DB06674 | DB06772 | 908 | 310 | [
"DDInter837",
"DDInter259"
] | Golimumab | Cabazitaxel | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Major | 2 | [
[
[
908,
25,
310
]
],
[
[
908,
64,
973
],
[
973,
24,
310
]
],
[
[
908,
25,
800
],
[
800,
63,
310
]
],
[
[
908,
63,
458
],
[
458,
24,... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
],
[
"Paclitaxel",
"{u} ma... | Golimumab may lead to a major life threatening interaction when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Golimumab may lead to a major life threatening interaction when taken with Duvelisib and Duvelisib may cause a moderate interac... |
DB09330 | DB10276 | 985 | 1,624 | [
"DDInter1352",
"DDInter1623"
] | Osimertinib | Rotavirus vaccine | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
985,
25,
1624
]
],
[
[
985,
63,
770
],
[
770,
25,
1624
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],
[
[
985,
64,
51
],
[
51,
25,
1624
]
],
[
[
985,
62,
168
],
[
168,
25... | [
[
[
"Osimertinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
],
[
"... | Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may lead to a major life threatening interaction when taken with Rotavirus vaccine
Osimertinib may lead to a major life threatening interaction when taken with Daunorubicin and Daunorubicin may lead t... |
DB00308 | DB01142 | 347 | 1,264 | [
"DDInter901",
"DDInter593"
] | Ibutilide | Doxepin | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
347,
25,
1264
]
],
[
[
347,
25,
401
],
[
401,
24,
1264
]
],
[
[
347,
6,
3958
],
[
3958,
45,
1264
]
],
[
[
347,
21,
29296
],
[
29296,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
],
[
"Promethazine",
"{u} ma... | Ibutilide may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Ibutilide (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Doxepin (Compound)
Ibutilide (Compound) causes Ventricular... |
DB09048 | DB11921 | 555 | 1,019 | [
"DDInter1284",
"DDInter492"
] | Netupitant | Deflazacort | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
555,
25,
1019
]
],
[
[
555,
63,
761
],
[
761,
24,
1019
]
],
[
[
555,
24,
214
],
[
214,
63,
1019
]
],
[
[
555,
24,
98
],
[
98,
24... | [
[
[
"Netupitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Netupitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
],
[
"Saxaglip... | Netupitant may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Netupitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and F... |
DB01259 | DB09237 | 392 | 1,586 | [
"DDInter1024",
"DDInter1045"
] | Lapatinib | Levamlodipine | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
392,
24,
1586
]
],
[
[
392,
24,
466
],
[
466,
62,
1586
]
],
[
[
392,
63,
870
],
[
870,
24,
1586
]
],
[
[
392,
25,
478
],
[
478,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone an... |
DB00436 | DB11126 | 323 | 900 | [
"DDInter179",
"DDInter276"
] | Bendroflumethiazide | Calcium gluconate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
323,
24,
900
]
],
[
[
323,
40,
674
],
[
674,
24,
900
]
],
[
[
323,
23,
1669
],
[
1669,
24,
900
]
],
[
[
323,
62,
964
],
[
964,
2... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlorme... | Bendroflumethiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Bendroflumethiazide may cause a minor interaction that can limit clinical effects when taken with Minocycline and Minocycline ma... |
DB00994 | DB01099 | 361 | 1,272 | [
"DDInter1277",
"DDInter744"
] | Neomycin | Flucytosine | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
361,
24,
1272
]
],
[
[
361,
21,
28658
],
[
28658,
60,
1272
]
],
[
[
361,
24,
1448
],
[
1448,
24,
1272
]
],
[
[
361,
24,
445
],
[
445,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Neomycin",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by... | Neomycin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Flucytosine (Compound)
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Flucytos... |
DB00218 | DB00431 | 1,176 | 1,503 | [
"DDInter1247",
"DDInter1072"
] | Moxifloxacin | Lindane | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Moderate | 1 | [
[
[
1176,
24,
1503
]
],
[
[
1176,
21,
28703
],
[
28703,
60,
1503
]
],
[
[
1176,
24,
1613
],
[
1613,
63,
1503
]
],
[
[
1176,
25,
820
],
[
8... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lindane"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is cause... | Moxifloxacin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Lindane (Compound)
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases wh... |
DB12147 | DB12332 | 241 | 1,619 | [
"DDInter661",
"DDInter1626"
] | Erdafitinib | Rucaparib | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
241,
24,
1619
]
],
[
[
241,
63,
1135
],
[
1135,
23,
1619
]
],
[
[
241,
63,
309
],
[
309,
24,
1619
]
],
[
[
241,
64,
913
],
[
913,
... | [
[
[
"Erdafitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Erdafitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Erdafitinib may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Erdafitinib may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepil... |
DB01267 | DB04837 | 519 | 649 | [
"DDInter1381",
"DDInter407"
] | Paliperidone | Clofedanol | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
519,
24,
649
]
],
[
[
519,
63,
1376
],
[
1376,
24,
649
]
],
[
[
519,
63,
832
],
[
832,
40,
649
]
],
[
[
519,
24,
1511
],
[
1511,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Tripele... |
DB00991 | DB08896 | 97 | 292 | [
"DDInter1358",
"DDInter1576"
] | Oxaprozin | Regorafenib | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
97,
25,
292
]
],
[
[
97,
6,
6017
],
[
6017,
45,
292
]
],
[
[
97,
21,
28890
],
[
28890,
60,
292
]
],
[
[
97,
63,
1560
],
[
1560,
... | [
[
[
"Oxaprozin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Oxaprozin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Regorafe... | Oxaprozin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Oxaprozin (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Regorafenib (Compound)
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB04843 | DB06016 | 1,511 | 1,508 | [
"DDInter1149",
"DDInter300"
] | Mepenzolate | Cariprazine | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1511,
24,
1508
]
],
[
[
1511,
63,
1507
],
[
1507,
24,
1508
]
],
[
[
1511,
40,
649
],
[
649,
24,
1508
]
],
[
[
1511,
24,
849
],
[
849,
... | [
[
[
"Mepenzolate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Mepenzolate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
... | Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Mepenzolate (Compound) resembles Clofedanol (Compound) and Clofedanol may cause a moderate interaction that ... |
DB01089 | DB06764 | 1,340 | 1,090 | [
"DDInter502",
"DDInter1788"
] | Deserpidine | Tetryzoline (ophthalmic) | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Moderate | 1 | [
[
[
1340,
24,
1090
]
],
[
[
1340,
63,
1148
],
[
1148,
24,
1090
]
],
[
[
1340,
1,
1245
],
[
1245,
24,
1090
]
],
[
[
1340,
37,
247
],
[
247,... | [
[
[
"Deserpidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetryzoline"
]
],
[
[
"Deserpidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
De... |
DB01018 | DB08816 | 1,364 | 578 | [
"DDInter847",
"DDInter1802"
] | Guanfacine | Ticagrelor | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1364,
24,
578
]
],
[
[
1364,
6,
8374
],
[
8374,
45,
578
]
],
[
[
1364,
21,
28762
],
[
28762,
60,
578
]
],
[
[
1364,
64,
723
],
[
723,
... | [
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Guanfacine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Guanfacine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Guanfacine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ticagrelor (Compound)
Guanfacine may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause ... |
DB01181 | DB01209 | 1,532 | 1,359 | [
"DDInter906",
"DDInter531"
] | Ifosfamide | Dezocine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
1532,
24,
1359
]
],
[
[
1532,
63,
234
],
[
234,
1,
1359
]
],
[
[
1532,
63,
717
],
[
717,
24,
1359
]
],
[
[
1532,
24,
516
],
[
516,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide and Trimethobenzamide may cause a moderate interact... |
DB00912 | DB08870 | 473 | 850 | [
"DDInter1581",
"DDInter228"
] | Repaglinide | Brentuximab vedotin | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
473,
24,
850
]
],
[
[
473,
24,
1338
],
[
1338,
24,
850
]
],
[
[
473,
24,
1033
],
[
1033,
63,
850
]
],
[
[
473,
63,
453
],
[
453,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic aci... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00106 | DB01601 | 618 | 833 | [
"DDInter4",
"DDInter1089"
] | Abarelix | Lopinavir | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Moderate | 1 | [
[
[
618,
24,
833
]
],
[
[
618,
25,
1327
],
[
1327,
40,
833
]
],
[
[
618,
24,
144
],
[
144,
63,
833
]
],
[
[
618,
24,
1555
],
[
1555,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
],
[
"Saquinavir",
... | Abarelix may lead to a major life threatening interaction when taken with Saquinavir and Saquinavir (Compound) resembles Lopinavir (Compound)
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases... |
DB01177 | DB01255 | 77 | 633 | [
"DDInter904",
"DDInter1078"
] | Idarubicin | Lisdexamfetamine | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
77,
24,
633
]
],
[
[
77,
21,
28751
],
[
28751,
60,
633
]
],
[
[
77,
62,
112
],
[
112,
23,
633
]
],
[
[
77,
63,
1494
],
[
1494,
2... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Idarubicin",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effect)... | Idarubicin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Lisdexamfetamine (Compound)
Idarubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken wi... |
DB01319 | DB08820 | 34 | 1,478 | [
"DDInter777",
"DDInter997"
] | Fosamprenavir | Ivacaftor | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Major | 2 | [
[
[
34,
25,
1478
]
],
[
[
34,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
34,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
34,
25,
1135
],
[
1135,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
]
],
[
[
"Fosamprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Iv... | Fosamprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Fosamprenavir (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Fosamprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may c... |
DB00078 | DB09054 | 1,172 | 384 | [
"DDInter898",
"DDInter905"
] | Ibritumomab tiuxetan | Idelalisib | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1172,
24,
384
]
],
[
[
1172,
24,
222
],
[
222,
23,
384
]
],
[
[
1172,
25,
1618
],
[
1618,
24,
384
]
],
[
[
1172,
24,
58
],
[
58,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutra... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Cabozantinib and... |
DB06700 | DB11186 | 643 | 1,609 | [
"DDInter511",
"DDInter1427"
] | Desvenlafaxine | Pentoxyverine | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
643,
24,
1609
]
],
[
[
643,
63,
104
],
[
104,
24,
1609
]
],
[
[
643,
64,
506
],
[
506,
24,
1609
]
],
[
[
643,
40,
1100
],
[
1100,
... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
... | Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Desvenlafaxine may lead to a major life threatening interaction when taken with Dextromethorphan and ... |
DB00348 | DB00701 | 254 | 1,091 | [
"DDInter1300",
"DDInter90"
] | Nitisinone | Amprenavir | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Amprenavir is a protease inhibitor used to treat HIV infection. | Moderate | 1 | [
[
[
254,
24,
1091
]
],
[
[
254,
24,
34
],
[
34,
1,
1091
]
],
[
[
254,
21,
28810
],
[
28810,
60,
1091
]
],
[
[
254,
24,
522
],
[
522,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
],
[... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir (Compound) resembles Amprenavir (Compound)
Nitisinone (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Amprenavir (Compound)
Nitisinone may... |
DB00321 | DB01619 | 21 | 830 | [
"DDInter78",
"DDInter1441"
] | Amitriptyline | Phenindamine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
21,
35,
830
]
],
[
[
21,
24,
537
],
[
537,
40,
830
]
],
[
[
21,
1,
114
],
[
114,
1,
830
]
],
[
[
21,
35,
1219
],
[
1219,
40,
... | [
[
[
"Amitriptyline",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Amitriptyline (Compound) resembles Phenindamine (Compound) and
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Amitriptyline (Compound) resembles Nortriptyline (Compound) and Nortriptyline (Compound) resem... |
DB00446 | DB01331 | 597 | 1,558 | [
"DDInter351",
"DDInter325"
] | Chloramphenicol | Cefoxitin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by <i>Streptomyces lactamdurans</i>. | Moderate | 1 | [
[
[
597,
24,
1558
]
],
[
[
597,
24,
665
],
[
665,
40,
1558
]
],
[
[
597,
24,
1402
],
[
1402,
1,
1558
]
],
[
[
597,
63,
277
],
[
277,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefoxitin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
],... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Cefoxitin (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cefotetan and Cefotetan (Compound) resembles Cefoxitin (Comp... |
DB01172 | DB01203 | 416 | 699 | [
"DDInter1004",
"DDInter1255"
] | Kanamycin | Nadolol | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Minor | 0 | [
[
[
416,
23,
699
]
],
[
[
416,
21,
28882
],
[
28882,
60,
699
]
],
[
[
416,
74,
361
],
[
361,
23,
699
]
],
[
[
416,
63,
1479
],
[
1479,
... | [
[
[
"Kanamycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nadolol"
]
],
[
[
"Kanamycin",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature increased",
... | Kanamycin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Nadolol (Compound)
Kanamycin (Compound) resembles Neomycin (Compound) and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cau... |
DB00475 | DB00902 | 1,119 | 104 | [
"DDInter355",
"DDInter1168"
] | Chlordiazepoxide | Methdilazine | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1119,
24,
104
]
],
[
[
1119,
63,
13
],
[
13,
24,
104
]
],
[
[
1119,
24,
820
],
[
820,
1,
104
]
],
[
[
1119,
24,
537
],
[
537,
40... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadin... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00281 | DB01158 | 608 | 1,286 | [
"DDInter1066",
"DDInter229"
] | Lidocaine | Bretylium | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of vol... | Moderate | 1 | [
[
[
608,
24,
1286
]
],
[
[
608,
21,
28653
],
[
28653,
60,
1286
]
],
[
[
608,
24,
976
],
[
976,
63,
1286
]
],
[
[
608,
24,
1010
],
[
1010,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bretylium"
]
],
[
[
"Lidocaine",
"{u} (Compound) causes {v} (Side Effect)",
"Bradycardia"
],
[
"Bradycardia",
"{u} (Side Effect) is cau... | Lidocaine (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Bretylium (Compound)
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Bret... |
DB00295 | DB00831 | 475 | 1,178 | [
"DDInter1244",
"DDInter1866"
] | Morphine | Trifluoperazine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Major | 2 | [
[
[
475,
25,
1178
]
],
[
[
475,
25,
695
],
[
695,
40,
1178
]
],
[
[
475,
24,
851
],
[
851,
40,
1178
]
],
[
[
475,
24,
9
],
[
9,
1,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"Clozapine",
"{u} (C... | Morphine may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Trifluoperazine (Compound)
Morphine ma... |
DB00620 | DB01116 | 175 | 601 | [
"DDInter1855",
"DDInter1872"
] | Triamcinolone | Trimethaphan | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Moderate | 1 | [
[
[
175,
24,
601
]
],
[
[
175,
24,
998
],
[
998,
1,
601
]
],
[
[
175,
6,
10558
],
[
10558,
45,
601
]
],
[
[
175,
25,
593
],
[
593,
6... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethaphan"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Trimethaphan (Compound)
Triamcinolone (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Trimethaphan (Compound)
Triamcinolone may lead to a major life threatening i... |
DB00564 | DB05812 | 1,236 | 1,374 | [
"DDInter293",
"DDInter8"
] | Carbamazepine | Abiraterone | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Major | 2 | [
[
[
1236,
25,
1374
]
],
[
[
1236,
6,
8374
],
[
8374,
45,
1374
]
],
[
[
1236,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
1236,
25,
466
],
[
46... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"... | Carbamazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Abiraterone (Compound)
Carbamazepine (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Carbamazepine may lead to a major life threatening interaction when taken with Darolutamide and ... |
DB00241 | DB06603 | 288 | 39 | [
"DDInter257",
"DDInter1387"
] | Butalbital | Panobinostat | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
288,
24,
39
]
],
[
[
288,
24,
112
],
[
112,
23,
39
]
],
[
[
288,
24,
272
],
[
272,
24,
39
]
],
[
[
288,
24,
578
],
[
578,
63,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramin... |
DB00444 | DB11901 | 63 | 913 | [
"DDInter1765",
"DDInter107"
] | Teniposide | Apalutamide | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
63,
24,
913
]
],
[
[
63,
24,
112
],
[
112,
23,
913
]
],
[
[
63,
24,
110
],
[
110,
62,
913
]
],
[
[
63,
24,
671
],
[
671,
24,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedo... |
DB01138 | DB03619 | 804 | 557 | [
"DDInter1726",
"DDInter501"
] | Sulfinpyrazone | Deoxycholic acid | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Moderate | 1 | [
[
[
804,
24,
557
]
],
[
[
804,
63,
1479
],
[
1479,
24,
557
]
],
[
[
804,
64,
126
],
[
126,
24,
557
]
],
[
[
804,
25,
405
],
[
405,
6... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicyl... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid
Sulfinpyrazone may lead to a major life threatening interaction when taken with Wa... |
DB00188 | DB11988 | 168 | 270 | [
"DDInter222",
"DDInter1321"
] | Bortezomib | Ocrelizumab | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
168,
24,
270
]
],
[
[
168,
63,
1461
],
[
1461,
23,
270
]
],
[
[
168,
24,
1060
],
[
1060,
63,
270
]
],
[
[
168,
24,
134
],
[
134,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and E... |
DB09312 | DB06688 | 967 | 1,430 | [
"DDInter106",
"DDInter1677"
] | Antithymocyte immunoglobulin (rabbit) | Sipuleucel-T | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin i... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
967,
24,
1430
]
],
[
[
967,
25,
676
],
[
676,
63,
1430
]
],
[
[
967,
24,
1531
],
[
1531,
24,
1430
]
],
[
[
967,
63,
713
],
[
713,
... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life threatening interaction when taken with... | Antilymphocyte immunoglobulin (horse) may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Antilymphocyte immunoglobulin (horse) may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate d... |
DB00209 | DB00836 | 352 | 543 | [
"DDInter1886",
"DDInter1088"
] | Trospium | Loperamide | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
352,
24,
543
]
],
[
[
352,
24,
704
],
[
704,
40,
543
]
],
[
[
352,
24,
675
],
[
675,
24,
543
]
],
[
[
352,
35,
262
],
[
262,
24,... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
"F... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Loperamide (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction th... |
DB00445 | DB01219 | 322 | 716 | [
"DDInter655",
"DDInter473"
] | Epirubicin | Dantrolene | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. | Moderate | 1 | [
[
[
322,
24,
716
]
],
[
[
322,
21,
28698
],
[
28698,
60,
716
]
],
[
[
322,
24,
267
],
[
267,
24,
716
]
],
[
[
322,
24,
1613
],
[
1613,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dantrolene"
]
],
[
[
"Epirubicin",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caused... | Epirubicin (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Dantrolene (Compound)
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Dantrolen... |
DB00912 | DB08882 | 473 | 1,281 | [
"DDInter1581",
"DDInter1070"
] | Repaglinide | Linagliptin | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
473,
24,
1281
]
],
[
[
473,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
473,
5,
11640
],
[
11640,
44,
1281
]
],
[
[
473,
6,
8374
],
[
8374,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Repaglinide (Compound) treats type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Linagliptin (Compound)
Repaglinide (Comp... |
DB00041 | DB00934 | 1,648 | 413 | [
"DDInter38",
"DDInter1124"
] | Aldesleukin | Maprotiline | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
1648,
24,
413
]
],
[
[
1648,
24,
1302
],
[
1302,
40,
413
]
],
[
[
1648,
24,
1264
],
[
1264,
63,
413
]
],
[
[
1648,
24,
999
],
[
999,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that co... |
DB00331 | DB00388 | 1,645 | 1,636 | [
"DDInter1164",
"DDInter1453"
] | Metformin | Phenylephrine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Moderate | 1 | [
[
[
1645,
24,
1636
]
],
[
[
1645,
24,
874
],
[
874,
40,
1636
]
],
[
[
1645,
24,
1148
],
[
1148,
63,
1636
]
],
[
[
1645,
21,
28956
],
[
289... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine (Compound) resembles Phenylephrine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction tha... |
DB00860 | DB11248 | 891 | 1,193 | [
"DDInter1513",
"DDInter1965"
] | Prednisolone | Zinc gluconate | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
891,
23,
1193
]
],
[
[
891,
24,
1531
],
[
1531,
23,
1193
]
],
[
[
891,
40,
167
],
[
167,
23,
1193
]
],
[
[
891,
24,
270
],
[
270,
... | [
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Prednisolone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a minor interacti... |
DB00860 | DB08895 | 891 | 976 | [
"DDInter1513",
"DDInter1825"
] | Prednisolone | Tofacitinib | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
891,
25,
976
]
],
[
[
891,
62,
307
],
[
307,
23,
976
]
],
[
[
891,
23,
1193
],
[
1193,
62,
976
]
],
[
[
891,
24,
214
],
[
214,
6... | [
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Modafini... | Prednisolone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc ... |
DB06616 | DB15091 | 594 | 676 | [
"DDInter224",
"DDInter1901"
] | Bosutinib | Upadacitinib | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
594,
25,
676
]
],
[
[
594,
24,
1430
],
[
1430,
24,
676
]
],
[
[
594,
64,
1249
],
[
1249,
24,
676
]
],
[
[
594,
25,
283
],
[
283,
... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipuleuc... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Bosutinib may lead to a major life threatening interaction when taken with Nafcillin and Nafcillin may caus... |
DB01128 | DB01254 | 918 | 1,213 | [
"DDInter204",
"DDInter484"
] | Bicalutamide | Dasatinib | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
918,
24,
1213
]
],
[
[
918,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
918,
18,
16974
],
[
16974,
57,
1213
]
],
[
[
918,
21,
28882
],
[
2888... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Bicalutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Bicalutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Bicalutamide (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Dasatinib (Compound)
Bicalutamide (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect)... |
DB00888 | DB15091 | 1,001 | 676 | [
"DDInter1133",
"DDInter1901"
] | Mechlorethamine | Upadacitinib | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1001,
25,
676
]
],
[
[
1001,
63,
1461
],
[
1461,
23,
676
]
],
[
[
1001,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1001,
63,
597
],
[
597,
... | [
[
[
"Mechlorethamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T ... |
DB00029 | DB11071 | 25 | 1,004 | [
"DDInter99",
"DDInter1449"
] | Anistreplase | Phenyl salicylate | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
25,
24,
1004
]
],
[
[
25,
25,
500
],
[
500,
24,
1004
]
],
[
[
25,
25,
235
],
[
235,
63,
1004
]
],
[
[
25,
24,
885
],
[
885,
24,
... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
... | Anistreplase may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Anistreplase may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a mode... |
DB00361 | DB00911 | 134 | 458 | [
"DDInter1939",
"DDInter1811"
] | Vinorelbine | Tinidazole | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
134,
24,
458
]
],
[
[
134,
24,
112
],
[
112,
1,
458
]
],
[
[
134,
6,
8374
],
[
8374,
45,
458
]
],
[
[
134,
18,
6348
],
[
6348,
5... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Vinorelbine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tinidazole (Compound)
Vinorelbine (Compound) downregulates IGFBP2 (Gene) and IGF... |
DB00065 | DB01076 | 581 | 700 | [
"DDInter923",
"DDInter133"
] | Infliximab | Atorvastatin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
581,
24,
700
]
],
[
[
581,
24,
788
],
[
788,
1,
700
]
],
[
[
581,
24,
303
],
[
303,
23,
700
]
],
[
[
581,
25,
896
],
[
896,
24,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Atorvastatin (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate may... |
DB00748 | DB00964 | 662 | 1,617 | [
"DDInter297",
"DDInter110"
] | Carbinoxamine | Apraclonidine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Moderate | 1 | [
[
[
662,
24,
1617
]
],
[
[
662,
63,
1020
],
[
1020,
1,
1617
]
],
[
[
662,
24,
1084
],
[
1084,
40,
1617
]
],
[
[
662,
63,
876
],
[
876,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Apraclonidine (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine and Lofexidine (Compound) resembles Apraclonidine (... |
DB01246 | DB11113 | 820 | 657 | [
"DDInter45",
"DDInter307"
] | Alimemazine | Castor oil | A phenothiazine derivative that is used as an antipruritic. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
820,
24,
657
]
],
[
[
820,
24,
1079
],
[
1079,
24,
657
]
],
[
[
820,
24,
927
],
[
927,
63,
657
]
],
[
[
820,
25,
540
],
[
540,
2... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
[
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Enc... |
DB06772 | DB15982 | 310 | 1,339 | [
"DDInter259",
"DDInter193"
] | Cabazitaxel | Berotralstat | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
310,
24,
1339
]
],
[
[
310,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
310,
63,
1213
],
[
1213,
24,
1339
]
],
[
[
310,
24,
351
],
[
351,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasat... |
DB00146 | DB00951 | 160 | 1,072 | [
"DDInter265",
"DDInter986"
] | Calcifediol | Isoniazid | The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
160,
24,
1072
]
],
[
[
160,
24,
115
],
[
115,
62,
1072
]
],
[
[
160,
24,
417
],
[
417,
23,
1072
]
],
[
[
160,
36,
386
],
[
386,
... | [
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
],... | Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide and Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Isoniazid
Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Sucral... |
DB00615 | DB09268 | 690 | 1,662 | [
"DDInter1589",
"DDInter1464"
] | Rifabutin | Picosulfuric acid | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
690,
24,
1662
]
],
[
[
690,
25,
484
],
[
484,
63,
1662
]
],
[
[
690,
24,
1619
],
[
1619,
63,
1662
]
],
[
[
690,
25,
1618
],
[
1618,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
],
[
"Entr... | Rifabutin may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may c... |
DB00373 | DB00388 | 461 | 1,636 | [
"DDInter1809",
"DDInter1453"
] | Timolol | Phenylephrine | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Moderate | 1 | [
[
[
461,
24,
1636
]
],
[
[
461,
25,
874
],
[
874,
40,
1636
]
],
[
[
461,
24,
1148
],
[
1148,
63,
1636
]
],
[
[
461,
25,
1674
],
[
1674,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
]
],
[
[
"Timolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
],
[
"Epinephrine"... | Timolol may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine (Compound) resembles Phenylephrine (Compound)
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate ... |
DB00176 | DB09049 | 529 | 1,135 | [
"DDInter770",
"DDInter1261"
] | Fluvoxamine | Naloxegol | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Minor | 0 | [
[
[
529,
23,
1135
]
],
[
[
529,
25,
1406
],
[
1406,
62,
1135
]
],
[
[
529,
24,
971
],
[
971,
62,
1135
]
],
[
[
529,
23,
1424
],
[
1424,
... | [
[
[
"Fluvoxamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
]
],
[
[
"Fluvoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
],
[
"Neratinib",
... | Fluvoxamine may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause... |
DB01067 | DB08907 | 959 | 1,344 | [
"DDInter826",
"DDInter280"
] | Glipizide | Canagliflozin | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
959,
24,
1344
]
],
[
[
959,
24,
549
],
[
549,
1,
1344
]
],
[
[
959,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
959,
21,
28681
],
[
28681,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Glipizide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Glipizide (Compound) causes Hypersensitivity (Side Effec... |
DB00284 | DB00372 | 1,647 | 999 | [
"DDInter11",
"DDInter1793"
] | Acarbose | Thiethylperazine | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
1647,
24,
999
]
],
[
[
1647,
24,
417
],
[
417,
23,
999
]
],
[
[
1647,
24,
651
],
[
651,
63,
999
]
],
[
[
1647,
24,
695
],
[
695,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosp... |
DB01193 | DB13142 | 819 | 841 | [
"DDInter12",
"DDInter274"
] | Acebutolol | Calcium glubionate anhydrous | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
819,
24,
841
]
],
[
[
819,
40,
887
],
[
887,
24,
841
]
],
[
[
819,
62,
1152
],
[
1152,
24,
841
]
],
[
[
819,
40,
887
],
[
887,
1... | [
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Acebutolol",
"{u} (Compound) resembles {v} (Compound)",
"Pindolol"
],
[
"Pindolol",
"{u} may c... | Acebutolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Acebutolol may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine may cause a moderate intera... |
DB01058 | DB09280 | 978 | 1,604 | [
"DDInter1510",
"DDInter1101"
] | Praziquantel | Lumacaftor | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
978,
25,
1604
]
],
[
[
978,
24,
1487
],
[
1487,
24,
1604
]
],
[
[
978,
63,
307
],
[
307,
24,
1604
]
],
[
[
978,
24,
907
],
[
907,
... | [
[
[
"Praziquantel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
[
... | Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB01191 | DB09038 | 1,039 | 1,450 | [
"DDInter518",
"DDInter636"
] | Dexfenfluramine | Empagliflozin | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1039,
24,
1450
]
],
[
[
1039,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
1039,
24,
885
],
[
885,
24,
1450
]
],
[
[
1039,
64,
1466
],
[
1466... | [
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
... | Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Epop... |
DB00574 | DB00675 | 121 | 888 | [
"DDInter717",
"DDInter1744"
] | Fenfluramine | Tamoxifen | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Major | 2 | [
[
[
121,
25,
888
]
],
[
[
121,
25,
939
],
[
939,
40,
888
]
],
[
[
121,
24,
256
],
[
256,
62,
888
]
],
[
[
121,
24,
477
],
[
477,
63,... | [
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Benzphetamine"
],
[
"Benzphetamine",
... | Fenfluramine may lead to a major life threatening interaction when taken with Benzphetamine and Benzphetamine (Compound) resembles Tamoxifen (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinic... |
DB00501 | DB01157 | 752 | 304 | [
"DDInter380",
"DDInter1875"
] | Cimetidine | Trimetrexate | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Minor | 0 | [
[
[
752,
23,
304
]
],
[
[
752,
21,
29093
],
[
29093,
60,
304
]
],
[
[
752,
62,
139
],
[
139,
24,
304
]
],
[
[
752,
24,
1362
],
[
1362,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trimetrexate"
]
],
[
[
"Cimetidine",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is caused b... | Cimetidine (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Trimetrexate (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexat... |
DB00872 | DB09079 | 1,080 | 1,496 | [
"DDInter438",
"DDInter1296"
] | Conivaptan | Nintedanib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
1080,
24,
1496
]
],
[
[
1080,
25,
609
],
[
609,
24,
1496
]
],
[
[
1080,
24,
850
],
[
850,
24,
1496
]
],
[
[
1080,
25,
927
],
[
927,
... | [
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clarit... | Conivaptan may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Bren... |
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