drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00209 | DB00734 | 352 | 1,664 | [
"DDInter1886",
"DDInter1605"
] | Trospium | Risperidone | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
352,
24,
1664
]
],
[
[
352,
24,
924
],
[
924,
40,
1664
]
],
[
[
352,
6,
12523
],
[
12523,
45,
1664
]
],
[
[
352,
21,
28787
],
[
28787,... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Risperidone (Compound)
Trospium (Compound) causes Dermatitis (Side Effect) and Dermatitis... |
DB00220 | DB01229 | 798 | 973 | [
"DDInter1276",
"DDInter1377"
] | Nelfinavir | Paclitaxel | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Major | 2 | [
[
[
798,
25,
973
]
],
[
[
798,
24,
310
],
[
310,
63,
973
]
],
[
[
798,
6,
7524
],
[
7524,
45,
973
]
],
[
[
798,
7,
5360
],
[
5360,
4... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitax... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Nelfinavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Nelfinavir (Comp... |
DB00279 | DB01185 | 1,152 | 155 | [
"DDInter1074",
"DDInter759"
] | Liothyronine | Fluoxymesterone | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Moderate | 1 | [
[
[
1152,
24,
155
]
],
[
[
1152,
24,
1546
],
[
1546,
40,
155
]
],
[
[
1152,
24,
1581
],
[
1581,
1,
155
]
],
[
[
1152,
24,
590
],
[
590,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Fluoxymesterone (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Testolactone and Testolactone (Compound) res... |
DB08875 | DB09098 | 1,618 | 98 | [
"DDInter262",
"DDInter1700"
] | Cabozantinib | Somatrem | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1618,
24,
98
]
],
[
[
1618,
25,
1612
],
[
1612,
62,
98
]
],
[
[
1618,
24,
159
],
[
159,
63,
98
]
],
[
[
1618,
64,
11
],
[
11,
24... | [
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Cabozantinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
],
[
"Fostems... | Cabozantinib may lead to a major life threatening interaction when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Somatrem
Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib ma... |
DB01001 | DB04844 | 688 | 843 | [
"DDInter1632",
"DDInter1778"
] | Salbutamol | Tetrabenazine | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
688,
24,
843
]
],
[
[
688,
63,
479
],
[
479,
40,
843
]
],
[
[
688,
21,
28698
],
[
28698,
60,
843
]
],
[
[
688,
62,
112
],
[
112,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Salbutamol (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Tetrabenazine (Compound)
Salbutamol may cause a minor interaction t... |
DB00023 | DB00621 | 305 | 1,026 | [
"DDInter127",
"DDInter1357"
] | Asparaginase Escherichia coli | Oxandrolone | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A synthetic hormone with anabolic and androgenic properties. | Moderate | 1 | [
[
[
305,
24,
1026
]
],
[
[
305,
24,
1546
],
[
1546,
1,
1026
]
],
[
[
305,
24,
473
],
[
473,
63,
1026
]
],
[
[
305,
24,
482
],
[
482,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Oxandrolone (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide an... |
DB00446 | DB00909 | 597 | 306 | [
"DDInter351",
"DDInter1971"
] | Chloramphenicol | Zonisamide | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Moderate | 1 | [
[
[
597,
24,
306
]
],
[
[
597,
6,
8374
],
[
8374,
45,
306
]
],
[
[
597,
21,
28734
],
[
28734,
60,
306
]
],
[
[
597,
24,
159
],
[
159,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zonisamide"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zonisamide (Compound)
Chloramphenicol (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Zonisamide (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate dis... |
DB05316 | DB08912 | 749 | 1,040 | [
"DDInter1467",
"DDInter462"
] | Pimavanserin | Dabrafenib | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
749,
24,
1040
]
],
[
[
749,
63,
1101
],
[
1101,
23,
1040
]
],
[
[
749,
64,
478
],
[
478,
24,
1040
]
],
[
[
749,
24,
1478
],
[
1478,
... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dabrafenib
Pimavanserin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause ... |
DB00577 | DB00877 | 1,295 | 629 | [
"DDInter1908",
"DDInter1678"
] | Valaciclovir | Sirolimus | Valaciclovir (valacyclovir), also known as _Valtrex_, is an antiviral drug that has been used to manage and treat various herpes infections for more than 2 decades. It was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline. Valacyclovir is the L-valine ester of aciclovir. It is a member o... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
1295,
25,
629
]
],
[
[
1295,
18,
15501
],
[
15501,
57,
629
]
],
[
[
1295,
21,
29203
],
[
29203,
60,
629
]
],
[
[
1295,
62,
752
],
[
75... | [
[
[
"Valaciclovir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Valaciclovir",
"{u} (Compound) downregulates {v} (Gene)",
"CCDC86"
],
[
"CCDC86",
"{u} (Gene) is downregulated by {v} (Compoun... | Valaciclovir (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sirolimus (Compound)
Valaciclovir (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Sirolimus (Compound)
Valaciclovir may cause a minor interac... |
DB00023 | DB00530 | 305 | 1,195 | [
"DDInter127",
"DDInter667"
] | Asparaginase Escherichia coli | Erlotinib | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Moderate | 1 | [
[
[
305,
24,
1195
]
],
[
[
305,
24,
883
],
[
883,
40,
1195
]
],
[
[
305,
24,
126
],
[
126,
63,
1195
]
],
[
[
305,
24,
322
],
[
322,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Erlotinib (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a ... |
DB00624 | DB12130 | 1,561 | 1,017 | [
"DDInter1776",
"DDInter1094"
] | Testosterone (topical) | Lorlatinib | Testosterone is an androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, an androstanoid, a C19-steroid and a 3-oxo-Delta(4) steroid. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1561,
24,
1017
]
],
[
[
1561,
63,
590
],
[
590,
24,
1017
]
],
[
[
1561,
25,
126
],
[
126,
24,
1017
]
],
[
[
1561,
24,
629
],
[
629,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
],
... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
... |
DB00307 | DB06212 | 1,101 | 165 | [
"DDInter202",
"DDInter1833"
] | Bexarotene | Tolvaptan | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
1101,
24,
165
]
],
[
[
1101,
23,
1080
],
[
1080,
1,
165
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
165
]
],
[
[
1101,
21,
28981
],
[
28981,... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Conivaptan"
],
[
... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Conivaptan and Conivaptan (Compound) resembles Tolvaptan (Compound)
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tolvaptan (Compound)
Bexarotene (Compound) causes Renal impairment (Side Effect) and Renal ... |
DB00530 | DB00776 | 1,195 | 1,335 | [
"DDInter667",
"DDInter1360"
] | Erlotinib | Oxcarbazepine | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
1195,
24,
1335
]
],
[
[
1195,
24,
126
],
[
126,
1,
1335
]
],
[
[
1195,
23,
307
],
[
307,
1,
1335
]
],
[
[
1195,
6,
7524
],
[
7524,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin (Compound) resembles Oxcarbazepine (Compound)
Erlotinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Oxcarbazepine (Compound)
Erlo... |
DB08916 | DB09291 | 26 | 741 | [
"DDInter32",
"DDInter1615"
] | Afatinib | Rolapitant | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
26,
24,
741
]
],
[
[
26,
63,
1671
],
[
1671,
24,
741
]
],
[
[
26,
24,
1180
],
[
1180,
63,
741
]
],
[
[
26,
64,
1510
],
[
1510,
2... | [
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
],
[
... | Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant and Rimegepa... |
DB00831 | DB08882 | 1,178 | 1,281 | [
"DDInter1866",
"DDInter1070"
] | Trifluoperazine | Linagliptin | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1178,
24,
1281
]
],
[
[
1178,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
1178,
6,
4973
],
[
4973,
45,
1281
]
],
[
[
1178,
21,
29081
],
[
290... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Trifluoperazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Linagliptin (Compound)
Trifluoperazine (Compound) causes Angioedema (Side Effec... |
DB01082 | DB01333 | 1,448 | 207 | [
"DDInter1713",
"DDInter328"
] | Streptomycin | Cefradine | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | A semi-synthetic cephalosporin antibiotic. | Moderate | 1 | [
[
[
1448,
24,
207
]
],
[
[
1448,
24,
315
],
[
315,
40,
207
]
],
[
[
1448,
63,
778
],
[
778,
1,
207
]
],
[
[
1448,
24,
1227
],
[
1227,
... | [
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefradine"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefprozil"
],
[
... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefprozil and Cefprozil (Compound) resembles Cefradine (Compound)
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefixime and Cefixime (Compound) resembles Cefradine (Compound)
Stre... |
DB00405 | DB00564 | 128 | 1,236 | [
"DDInter517",
"DDInter293"
] | Dexbrompheniramine | Carbamazepine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
128,
24,
1236
]
],
[
[
128,
24,
1405
],
[
1405,
40,
1236
]
],
[
[
128,
24,
508
],
[
508,
1,
1236
]
],
[
[
128,
63,
362
],
[
362,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cycloben... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine (Compound) resembles Carbamazepine (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resem... |
DB01110 | DB06589 | 86 | 1,250 | [
"DDInter1209",
"DDInter1400"
] | Miconazole | Pazopanib | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
86,
24,
1250
]
],
[
[
86,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
86,
7,
2692
],
[
2692,
45,
1250
]
],
[
[
86,
18,
2049
],
[
2049,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Miconazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Miconazole (Compound) upregulates KIT (Gene) and KIT (Gene) is bound by Pazopanib (Compound)
Miconazole (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is upregulated by Pazopanib (Compound)
Miconazole (Compound) cause... |
DB05154 | DB11901 | 740 | 913 | [
"DDInter1517",
"DDInter107"
] | Pretomanid | Apalutamide | Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy re... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
740,
25,
913
]
],
[
[
740,
24,
1450
],
[
1450,
24,
913
]
],
[
[
740,
25,
1040
],
[
1040,
24,
913
]
],
[
[
740,
63,
170
],
[
170,
... | [
[
[
"Pretomanid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Pretomanid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[
"Empagl... | Pretomanid may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Pretomanid may lead to a major life threatening interaction when taken with Dabrafenib and Dabrafenib may... |
DB00843 | DB00863 | 479 | 1,194 | [
"DDInter583",
"DDInter1568"
] | Donepezil | Ranitidine | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Moderate | 1 | [
[
[
479,
24,
1194
]
],
[
[
479,
6,
8374
],
[
8374,
45,
1194
]
],
[
[
479,
21,
29090
],
[
29090,
60,
1194
]
],
[
[
479,
23,
848
],
[
848,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
]
],
[
[
"Donepezil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Donepezil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ranitidine (Compound)
Donepezil (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Ranitidine (Compound)
Donepezil may cause a minor interaction that can limit clinical effects when taken with Ibuprofen ... |
DB06715 | DB08822 | 239 | 911 | [
"DDInter1500",
"DDInter156"
] | Potassium Iodide | Azilsartan medoxomil | Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyr... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Major | 2 | [
[
[
239,
25,
911
]
],
[
[
239,
64,
217
],
[
217,
1,
911
]
],
[
[
239,
21,
29081
],
[
29081,
60,
911
]
],
[
[
239,
63,
1512
],
[
1512,
... | [
[
[
"Potassium Iodide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Potassium Iodide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olmesartan"
],
[
"Olm... | Potassium Iodide may lead to a major life threatening interaction when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Potassium Iodide (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Azilsartan medoxomil (Compound)
Potassium Iodide may caus... |
DB00938 | DB04948 | 455 | 1,084 | [
"DDInter1635",
"DDInter1083"
] | Salmeterol | Lofexidine | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
455,
24,
1084
]
],
[
[
455,
63,
618
],
[
618,
24,
1084
]
],
[
[
455,
24,
774
],
[
774,
63,
1084
]
],
[
[
455,
24,
688
],
[
688,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abarelix"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Abarelix and Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degarelix m... |
DB00701 | DB00836 | 1,091 | 543 | [
"DDInter90",
"DDInter1088"
] | Amprenavir | Loperamide | Amprenavir is a protease inhibitor used to treat HIV infection. | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Major | 2 | [
[
[
1091,
25,
543
]
],
[
[
1091,
6,
8374
],
[
8374,
45,
543
]
],
[
[
1091,
21,
28722
],
[
28722,
60,
543
]
],
[
[
1091,
25,
1478
],
[
1478... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Loperamide"
]
],
[
[
"Amprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Loperam... | Amprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Loperamide (Compound)
Amprenavir (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Loperamide (Compound)
Amprenavir may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a mode... |
DB00009 | DB09030 | 1,271 | 840 | [
"DDInter56",
"DDInter1945"
] | Alteplase | Vorapaxar | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
1271,
25,
840
]
],
[
[
1271,
23,
944
],
[
944,
62,
840
]
],
[
[
1271,
24,
765
],
[
765,
24,
840
]
],
[
[
1271,
24,
1496
],
[
1496,
... | [
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Alteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Alteplase may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a mo... |
DB09074 | DB09389 | 1,362 | 517 | [
"DDInter1327",
"DDInter1315"
] | Olaparib | Norgestrel | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
1362,
24,
517
]
],
[
[
1362,
63,
14
],
[
14,
23,
517
]
],
[
[
1362,
24,
159
],
[
159,
63,
517
]
],
[
[
1362,
63,
86
],
[
86,
24,... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
],
[
... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB00477 | DB01067 | 216 | 959 | [
"DDInter363",
"DDInter826"
] | Chlorpromazine | Glipizide | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
216,
24,
959
]
],
[
[
216,
63,
245
],
[
245,
40,
959
]
],
[
[
216,
24,
1411
],
[
1411,
1,
959
]
],
[
[
216,
6,
8374
],
[
8374,
4... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (... |
DB01142 | DB15066 | 1,264 | 445 | [
"DDInter593",
"DDInter821"
] | Doxepin | Givosiran | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Moderate | 1 | [
[
[
1264,
24,
445
]
],
[
[
1264,
25,
1039
],
[
1039,
24,
445
]
],
[
[
1264,
63,
1555
],
[
1555,
24,
445
]
],
[
[
1264,
24,
1532
],
[
1532,... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Givosiran"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
"Dexfenfluram... | Doxepin may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may c... |
DB00373 | DB00816 | 461 | 1,674 | [
"DDInter1809",
"DDInter1346"
] | Timolol | Orciprenaline | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Major | 2 | [
[
[
461,
25,
1674
]
],
[
[
461,
25,
874
],
[
874,
24,
1674
]
],
[
[
461,
24,
1636
],
[
1636,
24,
1674
]
],
[
[
461,
6,
3576
],
[
3576,
... | [
[
[
"Timolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Orciprenaline"
]
],
[
[
"Timolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
],
[
"Epinephrine",
"{u} ma... | Timolol may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may c... |
DB00056 | DB00978 | 816 | 739 | [
"DDInter814",
"DDInter1084"
] | Gemtuzumab ozogamicin | Lomefloxacin | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Minor | 0 | [
[
[
816,
23,
739
]
],
[
[
816,
23,
945
],
[
945,
40,
739
]
],
[
[
816,
23,
1176
],
[
1176,
1,
739
]
],
[
[
816,
24,
482
],
[
482,
23... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparflo... | Gemtuzumab ozogamicin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Gemtuzumab ozogamicin may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) rese... |
DB00250 | DB09268 | 10 | 1,662 | [
"DDInter475",
"DDInter1464"
] | Dapsone | Picosulfuric acid | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
10,
24,
1662
]
],
[
[
10,
24,
595
],
[
595,
24,
1662
]
],
[
[
10,
24,
1619
],
[
1619,
63,
1662
]
],
[
[
10,
1,
1247
],
[
1247,
2... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethionamide"
],
[
... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide and Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruca... |
DB00488 | DB11601 | 196 | 1,270 | [
"DDInter57",
"DDInter1889"
] | Altretamine | Tuberculin purified protein derivative | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
196,
24,
1270
]
],
[
[
196,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
196,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
196,
63,
599
],
[
599,
... | [
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Altretamine may lead to a major life threatening interaction when taken with Clad... |
DB00918 | DB01168 | 1,373 | 1,053 | [
"DDInter49",
"DDInter1526"
] | Almotriptan | Procarbazine | Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that ... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
1373,
25,
1053
]
],
[
[
1373,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1373,
25,
1039
],
[
1039,
64,
1053
]
],
[
[
1373,
64,
1494
],
[
... | [
[
[
"Almotriptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Almotriptan",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Co... | Almotriptan (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Almotriptan may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may lead to a major life threatening interaction when taken with Procarbazine
Almotriptan ... |
DB01155 | DB04272 | 872 | 442 | [
"DDInter813",
"DDInter390"
] | Gemifloxacin | Citric acid | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020. ... | Moderate | 1 | [
[
[
872,
24,
442
]
],
[
[
872,
40,
1176
],
[
1176,
24,
442
]
],
[
[
872,
1,
945
],
[
945,
24,
442
]
],
[
[
872,
24,
115
],
[
115,
64... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citric acid"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} may cause ... | Gemifloxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Citric acid
Gemifloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00398 | DB01229 | 79 | 973 | [
"DDInter1702",
"DDInter1377"
] | Sorafenib | Paclitaxel | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
79,
24,
973
]
],
[
[
79,
24,
310
],
[
310,
63,
973
]
],
[
[
79,
5,
11570
],
[
11570,
44,
973
]
],
[
[
79,
6,
7524
],
[
7524,
45,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Sorafenib (Compound) treats kidney cancer (Disease) and kidney cancer (Disease) is treated by Paclitaxel (Compo... |
DB01059 | DB06589 | 956 | 1,250 | [
"DDInter1313",
"DDInter1400"
] | Norfloxacin | Pazopanib | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
956,
24,
1250
]
],
[
[
956,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
956,
21,
29203
],
[
29203,
60,
1250
]
],
[
[
956,
62,
112
],
[
112,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Norfloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)"... | Norfloxacin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Norfloxacin (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Pazopanib (Compound)
Norfloxacin may cause a minor interaction that can limit... |
DB00390 | DB00501 | 1,252 | 752 | [
"DDInter554",
"DDInter380"
] | Digoxin | Cimetidine | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
1252,
23,
752
]
],
[
[
1252,
6,
4973
],
[
4973,
45,
752
]
],
[
[
1252,
18,
3682
],
[
3682,
57,
752
]
],
[
[
1252,
21,
29551
],
[
29551... | [
[
[
"Digoxin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Digoxin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Ci... | Digoxin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound)
Digoxin (Compound) downregulates PIN1 (Gene) and PIN1 (Gene) is downregulated by Cimetidine (Compound)
Digoxin (Compound) causes Block heart (Side Effect) and Block heart (Side Effect) is caused by Cimetidine (Compound)
Digoxin may... |
DB00197 | DB01284 | 1,324 | 1,042 | [
"DDInter1881",
"DDInter1782"
] | Troglitazone | Tetracosactide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1324,
24,
1042
]
],
[
[
1324,
24,
455
],
[
455,
23,
1042
]
],
[
[
1324,
24,
659
],
[
659,
62,
1042
]
],
[
[
1324,
24,
811
],
[
811,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and ... |
DB00209 | DB09128 | 352 | 1,241 | [
"DDInter1886",
"DDInter231"
] | Trospium | Brexpiprazole | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
352,
24,
1241
]
],
[
[
352,
24,
407
],
[
407,
63,
1241
]
],
[
[
352,
24,
543
],
[
543,
24,
1241
]
],
[
[
352,
35,
262
],
[
262,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"O... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may ca... |
DB00577 | DB00795 | 1,295 | 50 | [
"DDInter1908",
"DDInter1725"
] | Valaciclovir | Sulfasalazine | Valaciclovir (valacyclovir), also known as _Valtrex_, is an antiviral drug that has been used to manage and treat various herpes infections for more than 2 decades. It was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline. Valacyclovir is the L-valine ester of aciclovir. It is a member o... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
1295,
24,
50
]
],
[
[
1295,
24,
712
],
[
712,
1,
50
]
],
[
[
1295,
23,
1096
],
[
1096,
63,
50
]
],
[
[
1295,
24,
1132
],
[
1132,
... | [
[
[
"Valaciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Valaciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
... | Valaciclovir may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine (Compound) resembles Sulfasalazine (Compound)
Valaciclovir may cause a minor interaction that can limit clinical effects when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate int... |
DB00446 | DB01591 | 597 | 667 | [
"DDInter351",
"DDInter1696"
] | Chloramphenicol | Solifenacin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
597,
24,
667
]
],
[
[
597,
6,
8374
],
[
8374,
45,
667
]
],
[
[
597,
21,
28703
],
[
28703,
60,
667
]
],
[
[
597,
24,
112
],
[
112,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (... | Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Solifenacin (Compound)
Chloramphenicol (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Solifenacin (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Metr... |
DB00983 | DB01182 | 480 | 371 | [
"DDInter776",
"DDInter1534"
] | Formoterol | Propafenone | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
480,
24,
371
]
],
[
[
480,
63,
847
],
[
847,
1,
371
]
],
[
[
480,
25,
772
],
[
772,
40,
371
]
],
[
[
480,
64,
1523
],
[
1523,
40... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Formoterol may lead to a major life threatening interaction when taken with Carvedilol and Carvedilol (Compound) resembles Propafenone (Compound)
Formoterol ... |
DB00448 | DB01072 | 1,215 | 915 | [
"DDInter1022",
"DDInter129"
] | Lansoprazole | Atazanavir | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Major | 2 | [
[
[
1215,
25,
915
]
],
[
[
1215,
24,
1327
],
[
1327,
1,
915
]
],
[
[
1215,
6,
4973
],
[
4973,
45,
915
]
],
[
[
1215,
21,
28660
],
[
28660,... | [
[
[
"Lansoprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Atazanavir"
]
],
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
[
"Saquin... | Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Lansoprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atazanavir (Compound)
Lansoprazole (Compound) causes Pelvic pain (Side Effect) and Pel... |
DB06372 | DB09123 | 259 | 1,525 | [
"DDInter1594",
"DDInter546"
] | Rilonacept | Dienogest | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in... | Moderate | 1 | [
[
[
259,
24,
1525
]
],
[
[
259,
64,
1064
],
[
1064,
24,
1525
]
],
[
[
259,
24,
1303
],
[
1303,
63,
1525
]
],
[
[
259,
63,
1531
],
[
1531,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dienogest"
]
],
[
[
"Rilonacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cladribine"... | Rilonacept may lead to a major life threatening interaction when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Dienogest
Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab and Guselkumab may cause a... |
DB00622 | DB01088 | 1,081 | 714 | [
"DDInter1287",
"DDInter908"
] | Nicardipine | Iloprost | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1081,
24,
714
]
],
[
[
1081,
24,
1479
],
[
1479,
24,
714
]
],
[
[
1081,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1081,
24,
1450
],
[
1450,... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with A... |
DB00501 | DB06207 | 752 | 910 | [
"DDInter380",
"DDInter1667"
] | Cimetidine | Silodosin | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Moderate | 1 | [
[
[
752,
24,
910
]
],
[
[
752,
6,
8374
],
[
8374,
45,
910
]
],
[
[
752,
21,
28921
],
[
28921,
60,
910
]
],
[
[
752,
24,
1264
],
[
1264,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Silodosin"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Silodosin (Compound)
Cimetidine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Silodosin (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin m... |
DB01254 | DB11915 | 1,213 | 1,293 | [
"DDInter484",
"DDInter1909"
] | Dasatinib | Valbenazine | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1213,
24,
1293
]
],
[
[
1213,
62,
112
],
[
112,
23,
1293
]
],
[
[
1213,
25,
710
],
[
710,
63,
1293
]
],
[
[
1213,
63,
521
],
[
521,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Dasatinib may lead to a major life threatening interaction when taken with Binimetinib and Binimetinib may cau... |
DB11581 | DB15982 | 1,456 | 1,339 | [
"DDInter1926",
"DDInter193"
] | Venetoclax | Berotralstat | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
1456,
25,
1339
]
],
[
[
1456,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
1456,
25,
283
],
[
283,
23,
1339
]
],
[
[
1456,
63,
1213
],
[
1213... | [
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Venetoclax may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause ... |
DB00660 | DB08870 | 1,470 | 850 | [
"DDInter1163",
"DDInter228"
] | Metaxalone | Brentuximab vedotin | Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1470,
24,
850
]
],
[
[
1470,
24,
267
],
[
267,
24,
850
]
],
[
[
1470,
63,
305
],
[
305,
24,
850
]
],
[
[
1470,
24,
384
],
[
384,
... | [
[
[
"Metaxalone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Metaxalone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],... | Metaxalone may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Metaxalone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase... |
DB00758 | DB11071 | 1,347 | 1,004 | [
"DDInter413",
"DDInter1449"
] | Clopidogrel | Phenyl salicylate | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1347,
24,
1004
]
],
[
[
1347,
63,
837
],
[
837,
23,
1004
]
],
[
[
1347,
23,
101
],
[
101,
23,
1004
]
],
[
[
1347,
64,
660
],
[
660,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pantoprazole"
... | Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Dexlansopraz... |
DB00486 | DB00831 | 1,614 | 1,178 | [
"DDInter1253",
"DDInter1866"
] | Nabilone | Trifluoperazine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1614,
24,
1178
]
],
[
[
1614,
63,
695
],
[
695,
40,
1178
]
],
[
[
1614,
24,
146
],
[
146,
40,
1178
]
],
[
[
1614,
24,
9
],
[
9,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine (Compound) resembles Trifluoperazine (Co... |
DB00363 | DB06655 | 695 | 5 | [
"DDInter419",
"DDInter1077"
] | Clozapine | Liraglutide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
695,
24,
5
]
],
[
[
695,
63,
245
],
[
245,
24,
5
]
],
[
[
695,
24,
480
],
[
480,
24,
5
]
],
[
[
695,
25,
1518
],
[
1518,
63,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formo... |
DB01203 | DB09082 | 699 | 659 | [
"DDInter1255",
"DDInter1934"
] | Nadolol | Vilanterol | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Major | 2 | [
[
[
699,
25,
659
]
],
[
[
699,
24,
1220
],
[
1220,
23,
659
]
],
[
[
699,
63,
891
],
[
891,
23,
659
]
],
[
[
699,
24,
1296
],
[
1296,
... | [
[
[
"Nadolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vilanterol"
]
],
[
[
"Nadolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
"Dexamethasone... | Nadolol may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Nadolol may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Predni... |
DB00242 | DB00347 | 1,064 | 917 | [
"DDInter392",
"DDInter1871"
] | Cladribine | Trimethadione | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Major | 2 | [
[
[
1064,
25,
917
]
],
[
[
1064,
7,
4456
],
[
4456,
46,
917
]
],
[
[
1064,
18,
7212
],
[
7212,
57,
917
]
],
[
[
1064,
21,
28769
],
[
28769... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimethadione"
]
],
[
[
"Cladribine",
"{u} (Compound) upregulates {v} (Gene)",
"NOTCH1"
],
[
"NOTCH1",
"{u} (Gene) is upregulated by {v} (Compound)",... | Cladribine (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Trimethadione (Compound)
Cladribine (Compound) downregulates HMG20B (Gene) and HMG20B (Gene) is downregulated by Trimethadione (Compound)
Cladribine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is ... |
DB00204 | DB00445 | 228 | 322 | [
"DDInter580",
"DDInter655"
] | Dofetilide | Epirubicin | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Major | 2 | [
[
[
228,
25,
322
]
],
[
[
228,
18,
6448
],
[
6448,
46,
322
]
],
[
[
228,
18,
10182
],
[
10182,
57,
322
]
],
[
[
228,
21,
28963
],
[
28963,... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epirubicin"
]
],
[
[
"Dofetilide",
"{u} (Compound) downregulates {v} (Gene)",
"CTSD"
],
[
"CTSD",
"{u} (Gene) is upregulated by {v} (Compound)",
... | Dofetilide (Compound) downregulates CTSD (Gene) and CTSD (Gene) is upregulated by Epirubicin (Compound)
Dofetilide (Compound) downregulates CDCA4 (Gene) and CDCA4 (Gene) is downregulated by Epirubicin (Compound)
Dofetilide (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Epirubicin (Compou... |
DB00514 | DB01174 | 506 | 697 | [
"DDInter527",
"DDInter1442"
] | Dextromethorphan | Phenobarbital | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
506,
24,
697
]
],
[
[
506,
24,
759
],
[
759,
1,
697
]
],
[
[
506,
63,
362
],
[
362,
1,
697
]
],
[
[
506,
63,
536
],
[
536,
40,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbit... |
DB00831 | DB00889 | 1,178 | 1,133 | [
"DDInter1866",
"DDInter840"
] | Trifluoperazine | Granisetron | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
1178,
24,
1133
]
],
[
[
1178,
63,
19
],
[
19,
40,
1133
]
],
[
[
1178,
63,
85
],
[
85,
1,
1133
]
],
[
[
1178,
18,
7359
],
[
7359,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (... |
DB00381 | DB08899 | 376 | 129 | [
"DDInter79",
"DDInter649"
] | Amlodipine | Enzalutamide | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
376,
25,
129
]
],
[
[
376,
6,
8374
],
[
8374,
45,
129
]
],
[
[
376,
21,
28703
],
[
28703,
60,
129
]
],
[
[
376,
24,
1512
],
[
1512,
... | [
[
[
"Amlodipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Enzal... | Amlodipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Amlodipine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Di... |
DB00333 | DB06595 | 576 | 1,491 | [
"DDInter1166",
"DDInter1214"
] | Methadone | Midostaurin | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
576,
25,
1491
]
],
[
[
576,
23,
112
],
[
112,
23,
1491
]
],
[
[
576,
36,
888
],
[
888,
24,
1491
]
],
[
[
576,
63,
58
],
[
58,
24... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Methadone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Methadone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Methadone (Compound) resembles Tamoxifen (Compound) and Methadone may lead to a major life threatening interac... |
DB00039 | DB01157 | 1,253 | 304 | [
"DDInter1380",
"DDInter1875"
] | Palifermin | Trimetrexate | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Moderate | 1 | [
[
[
1253,
24,
304
]
],
[
[
1253,
24,
599
],
[
599,
24,
304
]
],
[
[
1253,
24,
4
],
[
4,
63,
304
]
],
[
[
1253,
24,
1064
],
[
1064,
2... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimetrexate"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
],
[... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepes... |
DB09322 | DB15091 | 1,114 | 676 | [
"DDInter1966",
"DDInter1901"
] | Zinc sulfate | Upadacitinib | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Minor | 0 | [
[
[
1114,
23,
676
]
],
[
[
1114,
62,
1184
],
[
1184,
25,
676
]
],
[
[
1114,
23,
76
],
[
76,
25,
676
]
],
[
[
1114,
23,
725
],
[
725,
... | [
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Upadacitinib"
]
],
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Anakinra"
],
[
... | Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Anakinra and Anakinra may lead to a major life threatening interaction when taken with Upadacitinib
Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab and Mogamulizumab may le... |
DB00278 | DB01166 | 291 | 477 | [
"DDInter117",
"DDInter379"
] | Argatroban | Cilostazol | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
291,
25,
477
]
],
[
[
291,
6,
8374
],
[
8374,
45,
477
]
],
[
[
291,
21,
28892
],
[
28892,
60,
477
]
],
[
[
291,
23,
297
],
[
297,
... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Argatroban",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cilosta... | Argatroban (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Argatroban (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Cilostazol (Compound)
Argatroban may cause a minor interaction that can limit clinical effects when taken with Clove and C... |
DB00197 | DB00834 | 1,324 | 932 | [
"DDInter1881",
"DDInter1215"
] | Troglitazone | Mifepristone | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Moderate | 1 | [
[
[
1324,
24,
932
]
],
[
[
1324,
23,
1101
],
[
1101,
23,
932
]
],
[
[
1324,
24,
1499
],
[
1499,
63,
932
]
],
[
[
1324,
24,
723
],
[
723,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mifepristone"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Mifepristone
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine and Nal... |
DB00708 | DB01254 | 1,454 | 1,213 | [
"DDInter1718",
"DDInter484"
] | Sufentanil | Dasatinib | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1454,
24,
1213
]
],
[
[
1454,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
1454,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
1454,
25,
1133
],
[
1... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Sufentanil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Sufentanil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Sufentanil (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Sufentanil may lead to a major life threatening interaction when taken with Gr... |
DB09123 | DB11986 | 1,525 | 484 | [
"DDInter546",
"DDInter648"
] | Dienogest | Entrectinib | Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1525,
24,
484
]
],
[
[
1525,
25,
927
],
[
927,
24,
484
]
],
[
[
1525,
63,
1362
],
[
1362,
24,
484
]
],
[
[
1525,
25,
1476
],
[
1476,
... | [
[
[
"Dienogest",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Dienogest",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafeni... | Dienogest may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Dienogest may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a m... |
DB00342 | DB11901 | 1,181 | 913 | [
"DDInter1770",
"DDInter107"
] | Terfenadine | Apalutamide | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1181,
24,
913
]
],
[
[
1181,
23,
112
],
[
112,
23,
913
]
],
[
[
1181,
64,
600
],
[
600,
24,
913
]
],
[
[
1181,
24,
28
],
[
28,
2... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Terfenadine may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may... |
DB00749 | DB04932 | 59 | 1,564 | [
"DDInter699",
"DDInter491"
] | Etodolac | Defibrotide | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
59,
24,
1564
]
],
[
[
59,
24,
1039
],
[
1039,
24,
1564
]
],
[
[
59,
24,
738
],
[
738,
63,
1564
]
],
[
[
59,
63,
121
],
[
121,
24... | [
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
],
[
... | Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and ... |
DB00367 | DB01276 | 566 | 123 | [
"DDInter1061",
"DDInter706"
] | Levonorgestrel | Exenatide | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
566,
24,
123
]
],
[
[
566,
1,
1336
],
[
1336,
24,
123
]
],
[
[
566,
1,
984
],
[
984,
63,
123
]
],
[
[
566,
25,
1476
],
[
1476,
6... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) resembles {v} (Compound)",
"Etonogestrel"
],
[
"Etonogestrel",
"{u} may caus... | Levonorgestrel (Compound) resembles Etonogestrel (Compound) and Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Levonorgestrel (Compound) resembles Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Exenat... |
DB00574 | DB06655 | 121 | 5 | [
"DDInter717",
"DDInter1077"
] | Fenfluramine | Liraglutide | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
121,
24,
5
]
],
[
[
121,
63,
245
],
[
245,
24,
5
]
],
[
[
121,
24,
480
],
[
480,
24,
5
]
],
[
[
121,
64,
73
],
[
73,
24,
5... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and... |
DB00106 | DB00445 | 618 | 322 | [
"DDInter4",
"DDInter655"
] | Abarelix | Epirubicin | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
618,
24,
322
]
],
[
[
618,
23,
112
],
[
112,
62,
322
]
],
[
[
618,
24,
730
],
[
730,
63,
322
]
],
[
[
618,
24,
1570
],
[
1570,
2... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine and De... |
DB01166 | DB06788 | 477 | 1,616 | [
"DDInter379",
"DDInter864"
] | Cilostazol | Histrelin | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
477,
24,
1616
]
],
[
[
477,
62,
112
],
[
112,
23,
1616
]
],
[
[
477,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
477,
24,
623
],
[
623,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risp... |
DB00001 | DB01191 | 1,578 | 1,039 | [
"DDInter1037",
"DDInter518"
] | Lepirudin | Dexfenfluramine | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
1578,
24,
1039
]
],
[
[
1578,
25,
1046
],
[
1046,
63,
1039
]
],
[
[
1578,
24,
578
],
[
578,
63,
1039
]
],
[
[
1578,
24,
935
],
[
935,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
],
[
"Capla... | Lepirudin may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may... |
DB09052 | DB11627 | 250 | 1,367 | [
"DDInter220",
"DDInter860"
] | Blinatumomab | Hepatitis B Vaccine (Recombinant) | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
250,
24,
1367
]
],
[
[
250,
63,
1560
],
[
1560,
24,
1367
]
],
[
[
250,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
250,
24,
738
],
[
738,
... | [
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Blinatumomab may lead to a major life threatening interaction when taken with Cladr... |
DB00163 | DB06441 | 1,461 | 936 | [
"DDInter1943",
"DDInter283"
] | Vitamin E | Cangrelor | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Moderate | 1 | [
[
[
1461,
24,
936
]
],
[
[
1461,
24,
477
],
[
477,
24,
936
]
],
[
[
1461,
24,
1046
],
[
1046,
25,
936
]
],
[
[
1461,
24,
802
],
[
802,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cangrelor"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Cangrelor
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab and Caplaci... |
DB00363 | DB11130 | 695 | 407 | [
"DDInter419",
"DDInter1344"
] | Clozapine | Opium | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
695,
24,
407
]
],
[
[
695,
24,
662
],
[
662,
24,
407
]
],
[
[
695,
25,
976
],
[
976,
24,
407
]
],
[
[
695,
63,
1214
],
[
1214,
2... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Clozapine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause... |
DB00776 | DB11979 | 1,335 | 1,320 | [
"DDInter1360",
"DDInter625"
] | Oxcarbazepine | Elagolix | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1335,
24,
1320
]
],
[
[
1335,
62,
168
],
[
168,
23,
1320
]
],
[
[
1335,
24,
1297
],
[
1297,
24,
1320
]
],
[
[
1335,
63,
79
],
[
79,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Oxcarbazepine may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osil... |
DB00595 | DB01377 | 1,545 | 1,283 | [
"DDInter1374",
"DDInter1119"
] | Oxytetracycline | Magnesium oxide | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
1545,
24,
1283
]
],
[
[
1545,
63,
1252
],
[
1252,
23,
1283
]
],
[
[
1545,
24,
954
],
[
954,
23,
1283
]
],
[
[
1545,
24,
286
],
[
286,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
... | Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and ... |
DB00833 | DB09268 | 1,305 | 1,662 | [
"DDInter309",
"DDInter1464"
] | Cefaclor | Picosulfuric acid | Semisynthetic, broad-spectrum antibiotic derivative of cephalexin. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1305,
24,
1662
]
],
[
[
1305,
63,
597
],
[
597,
24,
1662
]
],
[
[
1305,
1,
319
],
[
319,
24,
1662
]
],
[
[
1305,
40,
339
],
[
339,
... | [
[
[
"Cefaclor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Cefaclor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
... | Cefaclor may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Cefaclor (Compound) resembles Amoxicillin (Compound) and Amoxicillin may cause a moderate interac... |
DB00612 | DB08907 | 1,121 | 1,344 | [
"DDInter216",
"DDInter280"
] | Bisoprolol | Canagliflozin | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1121,
24,
1344
]
],
[
[
1121,
24,
549
],
[
549,
1,
1344
]
],
[
[
1121,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
1121,
21,
28681
],
[
28681... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Bisoprolol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Bisoprolol (Compound) causes Hypersensitivity (Side Ef... |
DB00395 | DB00719 | 210 | 1,219 | [
"DDInter301",
"DDInter149"
] | Carisoprodol | Azatadine | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with b... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
210,
24,
1219
]
],
[
[
210,
24,
13
],
[
13,
24,
1219
]
],
[
[
210,
24,
830
],
[
830,
1,
1219
]
],
[
[
210,
24,
1376
],
[
1376,
6... | [
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Phenindami... |
DB00242 | DB00877 | 1,064 | 629 | [
"DDInter392",
"DDInter1678"
] | Cladribine | Sirolimus | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
1064,
25,
629
]
],
[
[
1064,
7,
3603
],
[
3603,
46,
629
]
],
[
[
1064,
18,
2697
],
[
2697,
46,
629
]
],
[
[
1064,
7,
4111
],
[
4111,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Cladribine",
"{u} (Compound) upregulates {v} (Gene)",
"ZFP36"
],
[
"ZFP36",
"{u} (Gene) is upregulated by {v} (Compound)",
... | Cladribine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Sirolimus (Compound)
Cladribine (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is upregulated by Sirolimus (Compound)
Cladribine (Compound) upregulates CCND3 (Gene) and CCND3 (Gene) is downregulated by Sirolimus (Compound)
Cladrib... |
DB00727 | DB01176 | 685 | 537 | [
"DDInter1304",
"DDInter453"
] | Nitroglycerin | Cyclizine | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Minor | 0 | [
[
[
685,
23,
537
]
],
[
[
685,
23,
1511
],
[
1511,
63,
537
]
],
[
[
685,
24,
104
],
[
104,
1,
537
]
],
[
[
685,
21,
28741
],
[
28741,
... | [
[
[
"Nitroglycerin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cyclizine"
]
],
[
[
"Nitroglycerin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mepenzolate"
],
[
... | Nitroglycerin may cause a minor interaction that can limit clinical effects when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and... |
DB00418 | DB06697 | 536 | 436 | [
"DDInter1650",
"DDInter121"
] | Secobarbital | Artemether | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Moderate | 1 | [
[
[
536,
24,
436
]
],
[
[
536,
6,
6017
],
[
6017,
45,
436
]
],
[
[
536,
63,
353
],
[
353,
24,
436
]
],
[
[
536,
24,
1220
],
[
1220,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Artemether"
]
],
[
[
"Secobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compoun... | Secobarbital (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Artemether (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Artemether
Secobarbit... |
DB00041 | DB01178 | 1,648 | 369 | [
"DDInter38",
"DDInter357"
] | Aldesleukin | Chlormezanone | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | Moderate | 1 | [
[
[
1648,
24,
369
]
],
[
[
1648,
24,
1532
],
[
1532,
63,
369
]
],
[
[
1648,
24,
1376
],
[
1376,
24,
369
]
],
[
[
1648,
25,
770
],
[
770,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlormezanone"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Chlormezanone
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine ... |
DB01169 | DB06176 | 57 | 1,342 | [
"DDInter120",
"DDInter1616"
] | Arsenic trioxide | Romidepsin | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
57,
25,
1342
]
],
[
[
57,
62,
1247
],
[
1247,
23,
1342
]
],
[
[
57,
64,
956
],
[
956,
24,
1342
]
],
[
[
57,
25,
1616
],
[
1616,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Arsenic trioxide may lead to a major life threatening interaction when taken with Norfloxacin and ... |
DB00308 | DB00445 | 347 | 322 | [
"DDInter901",
"DDInter655"
] | Ibutilide | Epirubicin | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Major | 2 | [
[
[
347,
25,
322
]
],
[
[
347,
21,
29024
],
[
29024,
60,
322
]
],
[
[
347,
23,
112
],
[
112,
62,
322
]
],
[
[
347,
25,
1670
],
[
1670,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epirubicin"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Hypertension"
],
[
"Hypertension",
"{u} (Side Effect) is caused by {v} (... | Ibutilide (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Epirubicin (Compound)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with E... |
DB08930 | DB09104 | 1,459 | 286 | [
"DDInter582",
"DDInter1118"
] | Dolutegravir | Magnesium hydroxide | Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and ... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Major | 2 | [
[
[
1459,
25,
286
]
],
[
[
1459,
62,
752
],
[
752,
23,
286
]
],
[
[
1459,
62,
1593
],
[
1593,
24,
286
]
],
[
[
1459,
64,
1283
],
[
1283,
... | [
[
[
"Dolutegravir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Dolutegravir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
],
[
... | Dolutegravir may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Dolutegravir may cause a minor interaction that can limit clinical effects when taken with Crizotinib and... |
DB00153 | DB00794 | 1,331 | 759 | [
"DDInter662",
"DDInter1521"
] | Ergocalciferol | Primidone | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
1331,
24,
759
]
],
[
[
1331,
24,
697
],
[
697,
40,
759
]
],
[
[
1331,
24,
362
],
[
362,
1,
759
]
],
[
[
1331,
6,
8374
],
[
8374,
... | [
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]... | Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (... |
DB00398 | DB09075 | 79 | 498 | [
"DDInter1702",
"DDInter621"
] | Sorafenib | Edoxaban | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
79,
25,
498
]
],
[
[
79,
24,
1237
],
[
1237,
24,
498
]
],
[
[
79,
24,
1017
],
[
1017,
63,
498
]
],
[
[
79,
64,
1230
],
[
1230,
2... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
"Clomipramine... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlat... |
DB00059 | DB04951 | 1,560 | 187 | [
"DDInter1404",
"DDInter1477"
] | Pegaspargase | Pirfenidone | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
1560,
24,
187
]
],
[
[
1560,
24,
168
],
[
168,
23,
187
]
],
[
[
1560,
24,
463
],
[
463,
24,
187
]
],
[
[
1560,
24,
996
],
[
996,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pirfenidone
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rif... |
DB00916 | DB01263 | 112 | 859 | [
"DDInter1202",
"DDInter1494"
] | Metronidazole | Posaconazole | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Minor | 0 | [
[
[
112,
23,
859
]
],
[
[
112,
6,
8374
],
[
8374,
45,
859
]
],
[
[
112,
21,
28762
],
[
28762,
60,
859
]
],
[
[
112,
24,
850
],
[
850,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Posaconazole"
]
],
[
[
"Metronidazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Posaconazole (Compound)
Metronidazole (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Brentuxi... |
DB00443 | DB01116 | 251 | 601 | [
"DDInter195",
"DDInter1872"
] | Betamethasone | Trimethaphan | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Moderate | 1 | [
[
[
251,
24,
601
]
],
[
[
251,
24,
998
],
[
998,
1,
601
]
],
[
[
251,
25,
593
],
[
593,
63,
601
]
],
[
[
251,
1,
891
],
[
891,
24,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethaphan"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Trimethaphan (Compound)
Betamethasone may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could ... |
DB00220 | DB00860 | 798 | 891 | [
"DDInter1276",
"DDInter1513"
] | Nelfinavir | Prednisolone | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
798,
24,
891
]
],
[
[
798,
63,
1351
],
[
1351,
40,
891
]
],
[
[
798,
25,
175
],
[
175,
40,
891
]
],
[
[
798,
24,
167
],
[
167,
1... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flunisolide"
],
[... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Prednisolone (Compound)
Nelfinavir may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Nel... |
DB00075 | DB06643 | 541 | 1,136 | [
"DDInter1250",
"DDInter500"
] | Muromonab | Denosumab | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
541,
24,
1136
]
],
[
[
541,
25,
1377
],
[
1377,
24,
1136
]
],
[
[
541,
25,
1510
],
[
1510,
63,
1136
]
],
[
[
541,
24,
270
],
[
270,
... | [
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Muromonab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
[
"Leflunomide"... | Muromonab may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Muromonab may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate... |
DB00705 | DB14568 | 441 | 982 | [
"DDInter496",
"DDInter1000"
] | Delavirdine | Ivosidenib | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
441,
25,
982
]
],
[
[
441,
63,
168
],
[
168,
23,
982
]
],
[
[
441,
25,
976
],
[
976,
24,
982
]
],
[
[
441,
24,
1559
],
[
1559,
2... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezom... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Delavirdine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may caus... |
DB00365 | DB06603 | 839 | 39 | [
"DDInter842",
"DDInter1387"
] | Grepafloxacin | Panobinostat | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
839,
25,
39
]
],
[
[
839,
23,
112
],
[
112,
23,
39
]
],
[
[
839,
24,
455
],
[
455,
24,
39
]
],
[
[
839,
23,
869
],
[
869,
24,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"M... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol ... |
DB10315 | DB12159 | 1,137 | 12 | [
"DDInter1127",
"DDInter609"
] | Measles virus vaccine live attenuated | Dupilumab | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | Major | 2 | [
[
[
1137,
25,
12
]
],
[
[
1137,
64,
599
],
[
599,
24,
12
]
],
[
[
1137,
64,
1011
],
[
1011,
25,
12
]
],
[
[
1137,
25,
676
],
[
676,
... | [
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dupilumab"
]
],
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alem... | Measles virus vaccine live attenuated may lead to a major life threatening interaction when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Dupilumab
Measles virus vaccine live attenuated may lead to a major life threatening interaction when taken w... |
DB00350 | DB00959 | 1,214 | 1,486 | [
"DDInter1226",
"DDInter1191"
] | Minoxidil | Methylprednisolone | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
1214,
24,
1486
]
],
[
[
1214,
24,
175
],
[
175,
40,
1486
]
],
[
[
1214,
24,
167
],
[
167,
1,
1486
]
],
[
[
1214,
24,
1382
],
[
1382,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Me... |
DB01067 | DB14006 | 959 | 972 | [
"DDInter826",
"DDInter370"
] | Glipizide | Choline salicylate | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
959,
24,
972
]
],
[
[
959,
62,
660
],
[
660,
23,
972
]
],
[
[
959,
63,
1573
],
[
1573,
24,
972
]
],
[
[
959,
24,
1117
],
[
1117,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Glipizide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
],
... | Glipizide may cause a minor interaction that can limit clinical effects when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and ... |
DB01320 | DB11921 | 651 | 1,019 | [
"DDInter783",
"DDInter492"
] | Fosphenytoin | Deflazacort | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
651,
25,
1019
]
],
[
[
651,
63,
959
],
[
959,
24,
1019
]
],
[
[
651,
24,
1619
],
[
1619,
63,
1019
]
],
[
[
651,
24,
761
],
[
761,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
"Glipiz... | Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruca... |
DB00744 | DB09074 | 1,288 | 1,362 | [
"DDInter1962",
"DDInter1327"
] | Zileuton | Olaparib | Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, a... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1288,
24,
1362
]
],
[
[
1288,
24,
2
],
[
2,
24,
1362
]
],
[
[
1288,
24,
1619
],
[
1619,
63,
1362
]
],
[
[
1288,
63,
1425
],
[
1425,
... | [
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alosetron"
],
[
"Al... | Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Alosetron and Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may c... |
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