drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00363 | DB01157 | 695 | 304 | [
"DDInter419",
"DDInter1875"
] | Clozapine | Trimetrexate | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Major | 2 | [
[
[
695,
25,
304
]
],
[
[
695,
24,
717
],
[
717,
40,
304
]
],
[
[
695,
64,
600
],
[
600,
23,
304
]
],
[
[
695,
24,
752
],
[
752,
23,... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimetrexate"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
],
[
"Tri... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide and Trimethobenzamide (Compound) resembles Trimetrexate (Compound)
Clozapine may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a minor interaction that can lim... |
DB00222 | DB00279 | 245 | 1,152 | [
"DDInter825",
"DDInter1074"
] | Glimepiride | Liothyronine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Moderate | 1 | [
[
[
245,
24,
1152
]
],
[
[
245,
24,
624
],
[
624,
40,
1152
]
],
[
[
245,
21,
29118
],
[
29118,
60,
1152
]
],
[
[
245,
24,
1523
],
[
1523,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Liothyronine (Compound)
Glimepiride (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Liothyronine (Compound)
Glimepiride may cause a moderate interac... |
DB00317 | DB11952 | 883 | 800 | [
"DDInter810",
"DDInter612"
] | Gefitinib | Duvelisib | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
883,
24,
800
]
],
[
[
883,
24,
1476
],
[
1476,
63,
800
]
],
[
[
883,
24,
663
],
[
663,
24,
800
]
],
[
[
883,
63,
1324
],
[
1324,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotr... |
DB06372 | DB10429 | 259 | 200 | [
"DDInter1594",
"DDInter282"
] | Rilonacept | Candida albicans | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
259,
24,
200
]
],
[
[
259,
63,
1096
],
[
1096,
24,
200
]
],
[
[
259,
25,
976
],
[
976,
24,
200
]
],
[
[
259,
24,
1019
],
[
1019,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Rilonacept may lead to a major life threatening interaction when taken with Tofacitinib and ... |
DB00619 | DB06448 | 1,419 | 171 | [
"DDInter909",
"DDInter1087"
] | Imatinib | Lonafarnib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Major | 2 | [
[
[
1419,
25,
171
]
],
[
[
1419,
23,
222
],
[
222,
23,
171
]
],
[
[
1419,
63,
1601
],
[
1601,
24,
171
]
],
[
[
1419,
24,
888
],
[
888,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lonafarnib"
]
],
[
[
"Imatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
"Sibutramine",
... | Imatinib may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Lonafarnib
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and Loratadine m... |
DB00065 | DB00175 | 581 | 681 | [
"DDInter923",
"DDInter1509"
] | Infliximab | Pravastatin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Moderate | 1 | [
[
[
581,
24,
681
]
],
[
[
581,
24,
1463
],
[
1463,
40,
681
]
],
[
[
581,
24,
126
],
[
126,
62,
681
]
],
[
[
581,
25,
322
],
[
322,
6... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pravastatin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
],
[
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin (Compound) resembles Pravastatin (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit c... |
DB00502 | DB01254 | 1,300 | 1,213 | [
"DDInter853",
"DDInter484"
] | Haloperidol | Dasatinib | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
1300,
25,
1213
]
],
[
[
1300,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
1300,
18,
2183
],
[
2183,
57,
1213
]
],
[
[
1300,
21,
28882
],
[
28... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Haloperidol",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatini... | Haloperidol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Haloperidol (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dasatinib (Compound)
Haloperidol (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is c... |
DB00694 | DB06603 | 51 | 39 | [
"DDInter485",
"DDInter1387"
] | Daunorubicin | Panobinostat | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
51,
25,
39
]
],
[
[
51,
23,
1247
],
[
1247,
23,
39
]
],
[
[
51,
24,
479
],
[
479,
23,
39
]
],
[
[
51,
63,
1257
],
[
1257,
24,
... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Donepez... |
DB00927 | DB01208 | 1,559 | 945 | [
"DDInter712",
"DDInter1705"
] | Famotidine | Sparfloxacin | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Moderate | 1 | [
[
[
1559,
24,
945
]
],
[
[
1559,
24,
739
],
[
739,
1,
945
]
],
[
[
1559,
63,
1176
],
[
1176,
1,
945
]
],
[
[
1559,
21,
28787
],
[
28787,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin... |
DB11642 | DB15091 | 938 | 676 | [
"DDInter1480",
"DDInter1901"
] | Pitolisant | Upadacitinib | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Moderate | 1 | [
[
[
938,
24,
676
]
],
[
[
938,
24,
283
],
[
283,
24,
676
]
],
[
[
938,
64,
1593
],
[
1593,
24,
676
]
],
[
[
938,
63,
600
],
[
600,
2... | [
[
[
"Pitolisant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Upadacitinib"
]
],
[
[
"Pitolisant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Pitolisant may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Pitolisant may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may caus... |
DB00204 | DB09082 | 228 | 659 | [
"DDInter580",
"DDInter1934"
] | Dofetilide | Vilanterol | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
228,
24,
659
]
],
[
[
228,
23,
1220
],
[
1220,
23,
659
]
],
[
[
228,
25,
870
],
[
870,
23,
659
]
],
[
[
228,
25,
927
],
[
927,
6... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Dofetilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
[
... | Dofetilide may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Dofetilide may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortison... |
DB00004 | DB08880 | 669 | 1,510 | [
"DDInter499",
"DDInter1771"
] | Denileukin diftitox | Teriflunomide | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
669,
25,
1510
]
],
[
[
669,
24,
221
],
[
221,
63,
1510
]
],
[
[
669,
24,
1136
],
[
1136,
24,
1510
]
],
[
[
669,
24,
713
],
[
713,
... | [
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 ant... | Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Denileukin difti... |
DB00938 | DB08871 | 455 | 36 | [
"DDInter1635",
"DDInter666"
] | Salmeterol | Eribulin | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
455,
24,
36
]
],
[
[
455,
24,
519
],
[
519,
24,
36
]
],
[
[
455,
63,
1424
],
[
1424,
24,
36
]
],
[
[
455,
25,
1056
],
[
1056,
24... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine... |
DB01129 | DB06717 | 379 | 875 | [
"DDInter1559",
"DDInter778"
] | Rabeprazole | Fosaprepitant | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
379,
24,
875
]
],
[
[
379,
63,
723
],
[
723,
1,
875
]
],
[
[
379,
21,
29340
],
[
29340,
60,
875
]
],
[
[
379,
24,
214
],
[
214,
... | [
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Rabeprazole (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Fosaprepitant (Compound)
Rabepr... |
DB00741 | DB01021 | 167 | 674 | [
"DDInter885",
"DDInter1861"
] | Hydrocortisone | Trichlormethiazide | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
167,
24,
674
]
],
[
[
167,
63,
1014
],
[
1014,
40,
674
]
],
[
[
167,
24,
178
],
[
178,
1,
674
]
],
[
[
167,
24,
359
],
[
359,
40... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazid... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resemble... |
DB00631 | DB01149 | 372 | 851 | [
"DDInter405",
"DDInter1274"
] | Clofarabine | Nefazodone | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
372,
24,
851
]
],
[
[
372,
21,
28762
],
[
28762,
60,
851
]
],
[
[
372,
63,
1101
],
[
1101,
23,
851
]
],
[
[
372,
24,
1374
],
[
1374,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Clofarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caus... | Clofarabine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nefazodone (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Nefazodon... |
DB01076 | DB01259 | 700 | 392 | [
"DDInter133",
"DDInter1024"
] | Atorvastatin | Lapatinib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
700,
24,
392
]
],
[
[
700,
6,
4973
],
[
4973,
45,
392
]
],
[
[
700,
18,
15501
],
[
15501,
57,
392
]
],
[
[
700,
63,
112
],
[
112,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Atorvastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Atorvastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Atorvastatin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Lapatinib (Compound)
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metro... |
DB09291 | DB15982 | 741 | 1,339 | [
"DDInter1615",
"DDInter193"
] | Rolapitant | Berotralstat | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
741,
25,
1339
]
],
[
[
741,
63,
1101
],
[
1101,
23,
1339
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],
[
[
741,
63,
761
],
[
761,
24,
1339
]
],
[
[
741,
24,
119
],
[
119,
... | [
[
[
"Rolapitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Rolapitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxag... |
DB00554 | DB00795 | 1,027 | 50 | [
"DDInter1478",
"DDInter1725"
] | Piroxicam | Sulfasalazine | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
1027,
24,
50
]
],
[
[
1027,
24,
712
],
[
712,
1,
50
]
],
[
[
1027,
40,
11272
],
[
11272,
1,
50
]
],
[
[
1027,
10,
11591
],
[
11591,
... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[
... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine (Compound) resembles Sulfasalazine (Compound)
Piroxicam (Compound) resembles Sulfapyridine (Compound) and Sulfapyridine (Compound) resembles Sulfasalazine (Compound)
Piroxicam (Compound) palliates ankylos... |
DB00005 | DB13915 | 1,057 | 689 | [
"DDInter687",
"DDInter146"
] | Etanercept | Axicabtagene ciloleucel | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Axicabtagene ciloleucel is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. The drug has a unique mechanism of action, as it utilizes the patient's own T cells, which play a central role in immune response to cancer. Once T-cells are collected from the patient, they are genetically engineered to express ant... | Major | 2 | [
[
[
1057,
25,
689
]
],
[
[
1057,
24,
599
],
[
599,
24,
689
]
],
[
[
1057,
25,
270
],
[
270,
24,
689
]
],
[
[
1057,
25,
976
],
[
976,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axicabtagene ciloleucel"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
],
[
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Axicabtagene ciloleucel
Etanercept may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrel... |
DB00014 | DB01238 | 521 | 673 | [
"DDInter839",
"DDInter118"
] | Goserelin | Aripiprazole | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
521,
24,
673
]
],
[
[
521,
24,
827
],
[
827,
40,
673
]
],
[
[
521,
24,
1630
],
[
1630,
1,
673
]
],
[
[
521,
21,
29461
],
[
29461,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Compou... |
DB04868 | DB11817 | 478 | 1,259 | [
"DDInter1293",
"DDInter165"
] | Nilotinib | Baricitinib | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
478,
25,
1259
]
],
[
[
478,
24,
949
],
[
949,
24,
1259
]
],
[
[
478,
63,
563
],
[
563,
24,
1259
]
],
[
[
478,
25,
927
],
[
927,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formalde... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Nilotinib ma... |
DB01229 | DB14711 | 973 | 779 | [
"DDInter1378",
"DDInter1680"
] | Paclitaxel (protein-bound) | Smallpox (Vaccinia) Vaccine, Live | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
973,
25,
779
]
],
[
[
973,
64,
1064
],
[
1064,
25,
779
]
],
[
[
973,
24,
478
],
[
478,
25,
779
]
],
[
[
973,
63,
147
],
[
147,
2... | [
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cl... | Paclitaxel may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Paclitaxel may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Paclitaxe... |
DB06372 | DB08879 | 259 | 632 | [
"DDInter1594",
"DDInter173"
] | Rilonacept | Belimumab | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Moderate | 1 | [
[
[
259,
24,
632
]
],
[
[
259,
62,
1461
],
[
1461,
23,
632
]
],
[
[
259,
23,
1114
],
[
1114,
62,
632
]
],
[
[
259,
24,
713
],
[
713,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belimumab"
]
],
[
[
"Rilonacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Rilonacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Belimumab
Rilonacept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate ... |
DB00370 | DB09291 | 1,251 | 741 | [
"DDInter1230",
"DDInter1615"
] | Mirtazapine | Rolapitant | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1251,
24,
741
]
],
[
[
1251,
25,
506
],
[
506,
24,
741
]
],
[
[
1251,
24,
159
],
[
159,
63,
741
]
],
[
[
1251,
24,
401
],
[
401,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextromethorphan"
],
[
"De... | Mirtazapine may lead to a major life threatening interaction when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Laro... |
DB08895 | DB10315 | 976 | 1,137 | [
"DDInter1825",
"DDInter1127"
] | Tofacitinib | Measles virus vaccine live attenuated | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
976,
25,
1137
]
],
[
[
976,
64,
1042
],
[
1042,
24,
1137
]
],
[
[
976,
25,
119
],
[
119,
64,
1137
]
],
[
[
976,
64,
273
],
[
273,
... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetracosactide"
],
[... | Tofacitinib may lead to a major life threatening interaction when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Tofacitinib may lead to a major life threatening interaction when taken with Talazoparib an... |
DB01618 | DB08824 | 776 | 591 | [
"DDInter1239",
"DDInter959"
] | Molindone | Ioflupane I-123 | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
776,
24,
591
]
],
[
[
776,
21,
28722
],
[
28722,
60,
591
]
],
[
[
776,
63,
401
],
[
401,
24,
591
]
],
[
[
776,
64,
1311
],
[
1311,
... | [
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Molindone",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused ... | Molindone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ioflupane I-123 (Compound)
Molindone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Ioflup... |
DB01233 | DB09065 | 1,311 | 760 | [
"DDInter1197",
"DDInter424"
] | Metoclopramide | Cobicistat | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1311,
24,
760
]
],
[
[
1311,
24,
1627
],
[
1627,
23,
760
]
],
[
[
1311,
63,
1230
],
[
1230,
23,
760
]
],
[
[
1311,
63,
523
],
[
523,
... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Citalopram an... |
DB00477 | DB08882 | 216 | 1,281 | [
"DDInter363",
"DDInter1070"
] | Chlorpromazine | Linagliptin | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
216,
24,
1281
]
],
[
[
216,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
216,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
216,
21,
29081
],
[
29081,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Chlorpromazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Chlorpromazine (Compound) causes Angioedema (Side Effect... |
DB00213 | DB01324 | 837 | 178 | [
"DDInter1388",
"DDInter1490"
] | Pantoprazole | Polythiazide | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
837,
24,
178
]
],
[
[
837,
24,
674
],
[
674,
40,
178
]
],
[
[
837,
21,
28835
],
[
28835,
60,
178
]
],
[
[
837,
24,
126
],
[
126,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
... | Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Pantoprazole (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Polythiazide (Compound)
Pantoprazo... |
DB08865 | DB09054 | 1,593 | 384 | [
"DDInter448",
"DDInter905"
] | Crizotinib | Idelalisib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
1593,
25,
384
]
],
[
[
1593,
64,
318
],
[
318,
23,
384
]
],
[
[
1593,
23,
1627
],
[
1627,
62,
384
]
],
[
[
1593,
62,
307
],
[
307,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escitalopram",
"{... | Crizotinib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Crizotinib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol and Cannabidiol may caus... |
DB01097 | DB09036 | 1,377 | 812 | [
"DDInter1033",
"DDInter1668"
] | Leflunomide | Siltuximab | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Major | 2 | [
[
[
1377,
25,
812
]
],
[
[
1377,
23,
1193
],
[
1193,
62,
812
]
],
[
[
1377,
62,
1461
],
[
1461,
23,
812
]
],
[
[
1377,
25,
287
],
[
287,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Siltuximab"
]
],
[
[
"Leflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc g... | Leflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Siltuximab
Leflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vit... |
DB01105 | DB09043 | 222 | 135 | [
"DDInter1665",
"DDInter36"
] | Sibutramine | Albiglutide | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
222,
24,
135
]
],
[
[
222,
63,
126
],
[
126,
23,
135
]
],
[
[
222,
24,
519
],
[
519,
24,
135
]
],
[
[
222,
63,
323
],
[
323,
24,... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliper... |
DB00460 | DB05239 | 612 | 866 | [
"DDInter1929",
"DDInter425"
] | Verteporfin | Cobimetinib | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
612,
24,
866
]
],
[
[
612,
24,
1069
],
[
1069,
63,
866
]
],
[
[
612,
24,
918
],
[
918,
24,
866
]
],
[
[
612,
63,
1101
],
[
1101,
... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vandetanib"
],
[... | Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Vandetanib and Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and B... |
DB00831 | DB09076 | 1,178 | 1,116 | [
"DDInter1866",
"DDInter1899"
] | Trifluoperazine | Umeclidinium | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1178,
24,
1116
]
],
[
[
1178,
24,
849
],
[
849,
24,
1116
]
],
[
[
1178,
1,
695
],
[
695,
24,
1116
]
],
[
[
1178,
35,
401
],
[
401,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Trifluoperazine (Compound) resembles Clozapine (Compound) and Clozapine may cause a moderate interaction ... |
DB06273 | DB11793 | 980 | 738 | [
"DDInter1824",
"DDInter1297"
] | Tocilizumab | Niraparib | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
980,
24,
738
]
],
[
[
980,
63,
663
],
[
663,
24,
738
]
],
[
[
980,
24,
496
],
[
496,
24,
738
]
],
[
[
980,
24,
1129
],
[
1129,
6... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
[... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vacc... |
DB00361 | DB00685 | 134 | 1,299 | [
"DDInter1939",
"DDInter1887"
] | Vinorelbine | Trovafloxacin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Minor | 0 | [
[
[
134,
23,
1299
]
],
[
[
134,
23,
872
],
[
872,
40,
1299
]
],
[
[
134,
18,
3199
],
[
3199,
45,
1299
]
],
[
[
134,
21,
29093
],
[
29093,
... | [
[
[
"Vinorelbine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Vinorelbine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
],
[... | Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Vinorelbine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Trovafloxacin (Compound)
Vinorelbine (Compound) causes Fatigue (Side Effect... |
DB00434 | DB00647 | 13 | 675 | [
"DDInter459",
"DDInter528"
] | Cyproheptadine | Dextropropoxyphene | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Major | 2 | [
[
[
13,
25,
675
]
],
[
[
13,
63,
494
],
[
494,
1,
675
]
],
[
[
13,
24,
1511
],
[
1511,
63,
675
]
],
[
[
13,
24,
649
],
[
649,
1,
... | [
[
[
"Cyproheptadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],
[... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Dextropropoxyphene (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate ... |
DB00196 | DB14975 | 600 | 988 | [
"DDInter743",
"DDInter1949"
] | Fluconazole | Voxelotor | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Major | 2 | [
[
[
600,
25,
988
]
],
[
[
600,
23,
222
],
[
222,
23,
988
]
],
[
[
600,
24,
251
],
[
251,
24,
988
]
],
[
[
600,
25,
629
],
[
629,
24,... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voxelotor"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
"Sibutramin... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Voxelotor
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Beta... |
DB00877 | DB05260 | 629 | 1,329 | [
"DDInter1678",
"DDInter804"
] | Sirolimus | Gallium nitrate | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Gallium nitrate is a nitrate salt of , a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for... | Major | 2 | [
[
[
629,
25,
1329
]
],
[
[
629,
21,
29118
],
[
29118,
60,
1329
]
],
[
[
629,
63,
1555
],
[
1555,
24,
1329
]
],
[
[
629,
25,
712
],
[
712,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gallium nitrate"
]
],
[
[
"Sirolimus",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect) is caused by {v... | Sirolimus (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Gallium nitrate (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB09075 | DB14730 | 498 | 1,412 | [
"DDInter621",
"DDInter264"
] | Edoxaban | Calaspargase pegol | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
498,
24,
1412
]
],
[
[
498,
64,
792
],
[
792,
24,
1412
]
],
[
[
498,
24,
1496
],
[
1496,
24,
1412
]
],
[
[
498,
63,
1151
],
[
1151,
... | [
[
[
"Edoxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
],
[
"Rivar... | Edoxaban may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Edoxaban may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may ... |
DB00960 | DB06663 | 887 | 1,154 | [
"DDInter1471",
"DDInter1398"
] | Pindolol | Pasireotide | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
887,
24,
1154
]
],
[
[
887,
63,
966
],
[
966,
40,
1154
]
],
[
[
887,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
887,
1,
88
],
[
88,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
... | Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Pindolol (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Pindolol (Compound) resembles Metopr... |
DB00014 | DB01211 | 521 | 609 | [
"DDInter839",
"DDInter393"
] | Goserelin | Clarithromycin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
521,
24,
609
]
],
[
[
521,
24,
1570
],
[
1570,
24,
609
]
],
[
[
521,
21,
28803
],
[
28803,
60,
609
]
],
[
[
521,
24,
600
],
[
600,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Goserelin (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Clarithromycin (... |
DB01045 | DB01229 | 463 | 973 | [
"DDInter1590",
"DDInter1377"
] | Rifampicin | Paclitaxel | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
463,
24,
973
]
],
[
[
463,
24,
310
],
[
310,
63,
973
]
],
[
[
463,
6,
7524
],
[
7524,
45,
973
]
],
[
[
463,
25,
214
],
[
214,
63... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Rifampicin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Rifampicin may l... |
DB01064 | DB13139 | 1,148 | 1,032 | [
"DDInter987",
"DDInter1063"
] | Isoprenaline | Levosalbutamol | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1148,
24,
1032
]
],
[
[
1148,
62,
218
],
[
218,
23,
1032
]
],
[
[
1148,
23,
1220
],
[
1220,
23,
1032
]
],
[
[
1148,
25,
1618
],
[
1618... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Isoprenaline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Beclomethasone diprop... | Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Beclomethasone dipropionate and Beclomethasone dipropionate may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Isoprenaline may cause a minor interaction that can limit clinical effects w... |
DB00512 | DB00515 | 91 | 589 | [
"DDInter1916",
"DDInter387"
] | Vancomycin | Cisplatin | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
91,
24,
589
]
],
[
[
91,
21,
28778
],
[
28778,
60,
589
]
],
[
[
91,
24,
1477
],
[
1477,
63,
589
]
],
[
[
91,
63,
894
],
[
894,
2... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Vancomycin",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphylactic shock",
"{u} (Sid... | Vancomycin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Cisplatin (Compound)
Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine and Telbivudine may cause a moderate interaction that could exacerbate diseases when... |
DB00694 | DB01159 | 51 | 419 | [
"DDInter485",
"DDInter854"
] | Daunorubicin | Halothane | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Moderate | 1 | [
[
[
51,
24,
419
]
],
[
[
51,
6,
8374
],
[
8374,
45,
419
]
],
[
[
51,
7,
15554
],
[
15554,
45,
419
]
],
[
[
51,
23,
112
],
[
112,
23,... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halothane"
]
],
[
[
"Daunorubicin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Daunorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halothane (Compound)
Daunorubicin (Compound) upregulates ATP2C1 (Gene) and ATP2C1 (Gene) is bound by Halothane (Compound)
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole m... |
DB00631 | DB06372 | 372 | 259 | [
"DDInter405",
"DDInter1594"
] | Clofarabine | Rilonacept | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
372,
24,
259
]
],
[
[
372,
63,
1461
],
[
1461,
23,
259
]
],
[
[
372,
24,
1619
],
[
1619,
63,
259
]
],
[
[
372,
24,
37
],
[
37,
2... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib... |
DB01067 | DB09381 | 959 | 192 | [
"DDInter826",
"DDInter678"
] | Glipizide | Esterified estrogens | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
959,
24,
192
]
],
[
[
959,
63,
752
],
[
752,
23,
192
]
],
[
[
959,
24,
1264
],
[
1264,
23,
192
]
],
[
[
959,
24,
1019
],
[
1019,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Dox... |
DB00388 | DB09100 | 1,636 | 320 | [
"DDInter1453",
"DDInter1799"
] | Phenylephrine | Thyroid, porcine | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
1636,
24,
320
]
],
[
[
1636,
24,
127
],
[
127,
24,
320
]
],
[
[
1636,
63,
1324
],
[
1324,
24,
320
]
],
[
[
1636,
24,
1296
],
[
1296,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Thyroid, porcine
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone ... |
DB00261 | DB00916 | 702 | 112 | [
"DDInter93",
"DDInter1202"
] | Anagrelide | Metronidazole | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
702,
23,
112
]
],
[
[
702,
21,
28757
],
[
28757,
60,
112
]
],
[
[
702,
25,
847
],
[
847,
23,
112
]
],
[
[
702,
25,
843
],
[
843,
... | [
[
[
"Anagrelide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Dyspepsia"
],
[
"Dyspepsia",
"{u} (Side Effect) is cau... | Anagrelide (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Metronidazole (Compound)
Anagrelide may lead to a major life threatening interaction when taken with Atomoxetine and Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Anagr... |
DB00288 | DB09045 | 1,103 | 52 | [
"DDInter63",
"DDInter607"
] | Amcinonide | Dulaglutide | Amcinonide is a corticosteroid. | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Minor | 0 | [
[
[
1103,
23,
52
]
],
[
[
1103,
23,
170
],
[
170,
23,
52
]
],
[
[
1103,
40,
870
],
[
870,
24,
52
]
],
[
[
1103,
1,
1573
],
[
1573,
2... | [
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dulaglutide"
]
],
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sitagliptin"
],
[
... | Amcinonide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Amcinonide (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction t... |
DB00727 | DB08907 | 685 | 1,344 | [
"DDInter1304",
"DDInter280"
] | Nitroglycerin | Canagliflozin | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
685,
24,
1344
]
],
[
[
685,
24,
549
],
[
549,
1,
1344
]
],
[
[
685,
21,
28681
],
[
28681,
60,
1344
]
],
[
[
685,
63,
999
],
[
999,
... | [
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
... | Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Nitroglycerin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Canagliflozin (Compound)
Nitroglyceri... |
DB00010 | DB08907 | 1,649 | 1,344 | [
"DDInter1661",
"DDInter280"
] | Sermorelin | Canagliflozin | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1649,
24,
1344
]
],
[
[
1649,
24,
549
],
[
549,
1,
1344
]
],
[
[
1649,
24,
176
],
[
176,
24,
1344
]
],
[
[
1649,
24,
1296
],
[
1296,
... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate i... |
DB00204 | DB01110 | 228 | 86 | [
"DDInter580",
"DDInter1209"
] | Dofetilide | Miconazole | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
228,
24,
86
]
],
[
[
228,
6,
3958
],
[
3958,
45,
86
]
],
[
[
228,
21,
29081
],
[
29081,
60,
86
]
],
[
[
228,
23,
1101
],
[
1101,
... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Dofetilide",
"{u} (Compound) binds {v} (Gene)",
"KCNH2"
],
[
"KCNH2",
"{u} (Gene) is bound by {v} (Compound)",
... | Dofetilide (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Miconazole (Compound)
Dofetilide (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Miconazole (Compound)
Dofetilide may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexaro... |
DB00352 | DB00533 | 482 | 1,416 | [
"DDInter1814",
"DDInter1613"
] | Tioguanine | Rofecoxib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Moderate | 1 | [
[
[
482,
24,
1416
]
],
[
[
482,
24,
384
],
[
384,
63,
1416
]
],
[
[
482,
63,
912
],
[
912,
24,
1416
]
],
[
[
482,
24,
1555
],
[
1555,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rofecoxib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Rofecoxib
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and... |
DB00861 | DB00975 | 914 | 1,317 | [
"DDInter551",
"DDInter573"
] | Diflunisal | Dipyridamole | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
914,
24,
1317
]
],
[
[
914,
21,
28748
],
[
28748,
60,
1317
]
],
[
[
914,
24,
714
],
[
714,
63,
1317
]
],
[
[
914,
63,
1167
],
[
1167,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Diflunisal",
"{u} (Compound) causes {v} (Side Effect)",
"Vertigo"
],
[
"Vertigo",
"{u} (Side Effect) is caused... | Diflunisal (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Dipyridamole (Compound)
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
... |
DB00112 | DB09498 | 374 | 810 | [
"DDInter201",
"DDInter1715"
] | Bevacizumab | Strontium chloride Sr-89 | There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its at... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
374,
24,
810
]
],
[
[
374,
24,
869
],
[
869,
24,
810
]
],
[
[
374,
25,
770
],
[
770,
24,
810
]
],
[
[
374,
24,
869
],
[
869,
63,... | [
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
... | Bevacizumab may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Bevacizumab may lead to a major life threatening interaction when taken with Thalidomide and Thalid... |
DB00394 | DB00524 | 218 | 811 | [
"DDInter168",
"DDInter1199"
] | Beclomethasone dipropionate | Metolazone | Beclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to [dexamethasone]. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor to mediates its therapeutic action. Bec... | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Moderate | 1 | [
[
[
218,
24,
811
]
],
[
[
218,
24,
1605
],
[
1605,
40,
811
]
],
[
[
218,
24,
1014
],
[
1014,
1,
811
]
],
[
[
218,
21,
28850
],
[
28850,
... | [
[
[
"Beclomethasone dipropionate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
]
],
[
[
"Beclomethasone dipropionate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Beclomethasone dipropionate may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Metolazone (Compound)
Beclomethasone dipropionate may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Comp... |
DB00215 | DB01088 | 1,230 | 714 | [
"DDInter388",
"DDInter908"
] | Citalopram | Iloprost | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1230,
24,
714
]
],
[
[
1230,
24,
1479
],
[
1479,
24,
714
]
],
[
[
1230,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1230,
1,
318
],
[
318,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Ald... |
DB00635 | DB00945 | 1,573 | 1,479 | [
"DDInter1515",
"DDInter20"
] | Prednisone | Acetylsalicylic acid | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1573,
24,
1479
]
],
[
[
1573,
24,
1338
],
[
1338,
24,
1479
]
],
[
[
1573,
6,
10215
],
[
10215,
45,
1479
]
],
[
[
1573,
10,
11666
],
[
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Prednisone (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Acetylsalicyli... |
DB01159 | DB12015 | 419 | 1,033 | [
"DDInter854",
"DDInter53"
] | Halothane | Alpelisib | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
419,
24,
1033
]
],
[
[
419,
63,
322
],
[
322,
24,
1033
]
],
[
[
419,
24,
1342
],
[
1342,
24,
1033
]
],
[
[
419,
25,
985
],
[
985,
... | [
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
[
... | Halothane may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsi... |
DB00022 | DB06210 | 268 | 72 | [
"DDInter1408",
"DDInter631"
] | Peginterferon alfa-2b | Eltrombopag | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Major | 2 | [
[
[
268,
25,
72
]
],
[
[
268,
24,
384
],
[
384,
63,
72
]
],
[
[
268,
24,
467
],
[
467,
24,
72
]
],
[
[
268,
25,
1064
],
[
1064,
24,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eltrombopag"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00969 | DB08899 | 2 | 129 | [
"DDInter52",
"DDInter649"
] | Alosetron | Enzalutamide | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
2,
24,
129
]
],
[
[
2,
6,
8374
],
[
8374,
45,
129
]
],
[
[
2,
21,
29179
],
[
29179,
60,
129
]
],
[
[
2,
24,
1510
],
[
1510,
24,
... | [
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Alosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Alosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Alosetron (Compound) causes Injury (Side Effect) and Injury (Side Effect) is caused by Enzalutamide (Compound)
Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide and Terifl... |
DB00780 | DB01612 | 551 | 1,637 | [
"DDInter1440",
"DDInter92"
] | Phenelzine | Amyl Nitrite | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
551,
24,
1637
]
],
[
[
551,
24,
714
],
[
714,
24,
1637
]
],
[
[
551,
64,
475
],
[
475,
24,
1637
]
],
[
[
551,
63,
1061
],
[
1061,
... | [
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
[
... | Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Phenelzine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a mode... |
DB00704 | DB01268 | 267 | 1,151 | [
"DDInter1263",
"DDInter1731"
] | Naltrexone | Sunitinib | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
267,
24,
1151
]
],
[
[
267,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
267,
18,
8386
],
[
8386,
46,
1151
]
],
[
[
267,
7,
3163
],
[
3163,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Naltrexone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Naltrexone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Naltrexone (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Sunitinib (Compound)
Naltrexone (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Sunitinib (Compound)
Naltrexone (Com... |
DB00862 | DB00938 | 1,005 | 455 | [
"DDInter1918",
"DDInter1635"
] | Vardenafil | Salmeterol | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1005,
24,
455
]
],
[
[
1005,
24,
688
],
[
688,
63,
455
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
455
]
],
[
[
1005,
21,
28722
],
[
28722,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Salmeterol (Compound)
Vardenafil (Compou... |
DB00649 | DB01611 | 231 | 1,487 | [
"DDInter1710",
"DDInter893"
] | Stavudine | Hydroxychloroquine | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
231,
24,
1487
]
],
[
[
231,
7,
2216
],
[
2216,
46,
1487
]
],
[
[
231,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
231,
63,
663
],
[
663,
... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Stavudine",
"{u} (Compound) upregulates {v} (Gene)",
"PAK1"
],
[
"PAK1",
"{u} (Gene) is upregulated by {v... | Stavudine (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Hydroxychloroquine (Compound)
Stavudine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Stavudine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00352 | DB08908 | 482 | 713 | [
"DDInter1814",
"DDInter564"
] | Tioguanine | Dimethyl fumarate | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
482,
24,
713
]
],
[
[
482,
24,
996
],
[
996,
24,
713
]
],
[
[
482,
24,
725
],
[
725,
63,
713
]
],
[
[
482,
63,
552
],
[
552,
24,... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
],
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab... |
DB00361 | DB12674 | 134 | 975 | [
"DDInter1939",
"DDInter1105"
] | Vinorelbine | Lurbinectedin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
134,
24,
975
]
],
[
[
134,
24,
1488
],
[
1488,
24,
975
]
],
[
[
134,
24,
159
],
[
159,
63,
975
]
],
[
[
134,
63,
482
],
[
482,
2... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib ... |
DB00069 | DB00911 | 367 | 458 | [
"DDInter946",
"DDInter1811"
] | Interferon alfacon-1 | Tinidazole | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
367,
24,
458
]
],
[
[
367,
24,
112
],
[
112,
1,
458
]
],
[
[
367,
24,
238
],
[
238,
24,
458
]
],
[
[
367,
24,
310
],
[
310,
63,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metroni... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol and Ethambutol may cause a moder... |
DB00242 | DB15719 | 1,064 | 487 | [
"DDInter392",
"DDInter171"
] | Cladribine | Belantamab mafodotin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Major | 2 | [
[
[
1064,
25,
487
]
],
[
[
1064,
64,
440
],
[
440,
24,
487
]
],
[
[
1064,
25,
810
],
[
810,
24,
487
]
],
[
[
1064,
24,
869
],
[
869,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Filgrastim"
],
[
"Filgrastim",
... | Cladribine may lead to a major life threatening interaction when taken with Filgrastim and Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Cladribine may lead to a major life threatening interaction when taken with Strontium chloride Sr-89 and Strontium ch... |
DB00046 | DB00618 | 1,179 | 1,572 | [
"DDInter940",
"DDInter498"
] | Insulin lispro | Demeclocycline | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Moderate | 1 | [
[
[
1179,
24,
1572
]
],
[
[
1179,
24,
1620
],
[
1620,
1,
1572
]
],
[
[
1179,
24,
1669
],
[
1669,
40,
1572
]
],
[
[
1179,
24,
1680
],
[
168... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles Demeclocycline (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Minocycline and Minocycline (Compound) resembles Deme... |
DB00432 | DB08895 | 1,083 | 976 | [
"DDInter1868",
"DDInter1825"
] | Trifluridine | Tofacitinib | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1083,
25,
976
]
],
[
[
1083,
63,
1461
],
[
1461,
23,
976
]
],
[
[
1083,
24,
200
],
[
200,
63,
976
]
],
[
[
1083,
24,
1430
],
[
1430,
... | [
[
[
"Trifluridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitami... | Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and... |
DB01097 | DB06043 | 1,377 | 1,644 | [
"DDInter1033",
"DDInter1328"
] | Leflunomide | Olaratumab | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Stu... | Major | 2 | [
[
[
1377,
25,
1644
]
],
[
[
1377,
25,
1531
],
[
1531,
63,
1644
]
],
[
[
1377,
64,
1184
],
[
1184,
24,
1644
]
],
[
[
1377,
24,
1367
],
[
13... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaratumab"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Canakinumab"
],
[
"Canakinumab",
"{... | Leflunomide may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaratumab
Leflunomide may lead to a major life threatening interaction when taken with Anakinra and Anakinra may cause a moderate inte... |
DB00353 | DB00673 | 588 | 723 | [
"DDInter1187",
"DDInter112"
] | Methylergometrine | Aprepitant | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
588,
24,
723
]
],
[
[
588,
6,
8374
],
[
8374,
45,
723
]
],
[
[
588,
21,
28770
],
[
28770,
60,
723
]
],
[
[
588,
63,
1101
],
[
1101,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Methylergometrine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v... | Methylergometrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aprepitant (Compound)
Methylergometrine (Compound) causes Haematuria (Side Effect) and Haematuria (Side Effect) is caused by Aprepitant (Compound)
Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB12130 | DB15035 | 1,017 | 503 | [
"DDInter1094",
"DDInter1959"
] | Lorlatinib | Zanubrutinib | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1017,
25,
503
]
],
[
[
1017,
63,
868
],
[
868,
24,
503
]
],
[
[
1017,
64,
1362
],
[
1362,
24,
503
]
],
[
[
1017,
24,
1619
],
[
1619,
... | [
[
[
"Lorlatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Lorlatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
"Vemuraf... | Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Lorlatinib may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause ... |
DB00902 | DB01612 | 104 | 1,637 | [
"DDInter1168",
"DDInter92"
] | Methdilazine | Amyl Nitrite | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
104,
24,
1637
]
],
[
[
104,
63,
946
],
[
946,
24,
1637
]
],
[
[
104,
24,
180
],
[
180,
63,
1637
]
],
[
[
104,
24,
413
],
[
413,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Buspirone"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Buspirone and Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine and O... |
DB01142 | DB12245 | 1,264 | 823 | [
"DDInter593",
"DDInter1863"
] | Doxepin | Triclabendazole | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1264,
24,
823
]
],
[
[
1264,
62,
1247
],
[
1247,
23,
823
]
],
[
[
1264,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1264,
63,
1010
],
[
1010,... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[... | Doxepin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir an... |
DB00501 | DB00820 | 752 | 402 | [
"DDInter380",
"DDInter1736"
] | Cimetidine | Tadalafil | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Moderate | 1 | [
[
[
752,
24,
402
]
],
[
[
752,
6,
8374
],
[
8374,
45,
402
]
],
[
[
752,
21,
29106
],
[
29106,
60,
402
]
],
[
[
752,
24,
159
],
[
159,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tadalafil"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tadalafil (Compound)
Cimetidine (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Tadalafil (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotre... |
DB04946 | DB06655 | 924 | 5 | [
"DDInter907",
"DDInter1077"
] | Iloperidone | Liraglutide | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
924,
24,
5
]
],
[
[
924,
63,
245
],
[
245,
24,
5
]
],
[
[
924,
25,
1491
],
[
1491,
24,
5
]
],
[
[
924,
40,
1664
],
[
1664,
24,
... | [
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Iloperidone may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may... |
DB00549 | DB08870 | 522 | 850 | [
"DDInter1955",
"DDInter228"
] | Zafirlukast | Brentuximab vedotin | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
522,
24,
850
]
],
[
[
522,
24,
788
],
[
788,
24,
850
]
],
[
[
522,
24,
1033
],
[
1033,
63,
850
]
],
[
[
522,
23,
807
],
[
807,
2... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Alpeli... |
DB00242 | DB00531 | 1,064 | 450 | [
"DDInter392",
"DDInter456"
] | Cladribine | Cyclophosphamide | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Major | 2 | [
[
[
1064,
25,
450
]
],
[
[
1064,
25,
1001
],
[
1001,
40,
450
]
],
[
[
1064,
21,
28725
],
[
28725,
60,
450
]
],
[
[
1064,
64,
491
],
[
491,... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclophosphamide"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mechlorethamine"
],
[
"Mechlorethamin... | Cladribine may lead to a major life threatening interaction when taken with Mechlorethamine and Mechlorethamine (Compound) resembles Cyclophosphamide (Compound)
Cladribine (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Cyclophosphamide (Compound)
Cladribine may lead to a major ... |
DB00261 | DB00321 | 702 | 21 | [
"DDInter93",
"DDInter78"
] | Anagrelide | Amitriptyline | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Major | 2 | [
[
[
702,
25,
21
]
],
[
[
702,
25,
1237
],
[
1237,
40,
21
]
],
[
[
702,
25,
1164
],
[
1164,
1,
21
]
],
[
[
702,
24,
1405
],
[
1405,
4... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amitriptyline"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomipramine"
],
[
"Clomipramine",
... | Anagrelide may lead to a major life threatening interaction when taken with Clomipramine and Clomipramine (Compound) resembles Amitriptyline (Compound)
Anagrelide may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Amitriptyline (Compound)
Anagrelide may c... |
DB00030 | DB00679 | 1,685 | 684 | [
"DDInter934",
"DDInter1796"
] | Insulin human | Thioridazine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Moderate | 1 | [
[
[
1685,
24,
684
]
],
[
[
1685,
24,
216
],
[
216,
1,
684
]
],
[
[
1685,
24,
417
],
[
417,
23,
684
]
],
[
[
1685,
24,
761
],
[
761,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpromazine"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thioridazine (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interacti... |
DB00041 | DB00987 | 1,648 | 1,224 | [
"DDInter38",
"DDInter460"
] | Aldesleukin | Cytarabine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Moderate | 1 | [
[
[
1648,
24,
1224
]
],
[
[
1648,
23,
872
],
[
872,
62,
1224
]
],
[
[
1648,
23,
739
],
[
739,
23,
1224
]
],
[
[
1648,
24,
322
],
[
322,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
],
[
... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Cytarabine
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lome... |
DB01359 | DB01362 | 729 | 497 | [
"DDInter1417",
"DDInter960"
] | Penbutolol | Iohexol | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Moderate | 1 | [
[
[
729,
24,
497
]
],
[
[
729,
21,
28719
],
[
28719,
60,
497
]
],
[
[
729,
1,
668
],
[
668,
24,
497
]
],
[
[
729,
40,
461
],
[
461,
... | [
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
]
],
[
[
"Penbutolol",
"{u} (Compound) causes {v} (Side Effect)",
"Pain"
],
[
"Pain",
"{u} (Side Effect) is caused by {v} (Co... | Penbutolol (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Iohexol (Compound)
Penbutolol (Compound) resembles Levobunolol (Compound) and Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
Penbutolol (Compound) resembles Timolol (Compound) and Tim... |
DB00384 | DB09020 | 1,275 | 28 | [
"DDInter1859",
"DDInter212"
] | Triamterene | Bisacodyl | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1275,
24,
28
]
],
[
[
1275,
18,
2183
],
[
2183,
57,
28
]
],
[
[
1275,
21,
28809
],
[
28809,
60,
28
]
],
[
[
1275,
24,
870
],
[
870,
... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Triamterene",
"{u} (Compound) downregulates {v} (Gene)",
"CDC20"
],
[
"CDC20",
"{u} (Gene) is downregulated by {... | Triamterene (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Bisacodyl (Compound)
Triamterene (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Bisacodyl (Compound)
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Flud... |
DB00995 | DB08889 | 1,112 | 350 | [
"DDInter139",
"DDInter299"
] | Auranofin | Carfilzomib | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
1112,
24,
350
]
],
[
[
1112,
21,
28745
],
[
28745,
60,
350
]
],
[
[
1112,
24,
310
],
[
310,
24,
350
]
],
[
[
1112,
63,
1451
],
[
1451,... | [
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Auranofin",
"{u} (Compound) causes {v} (Side Effect)",
"Neuropathy peripheral"
],
[
"Neuropathy peripheral",
"{u... | Auranofin (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Carfilzomib (Compound)
Auranofin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate disease... |
DB00983 | DB01403 | 480 | 9 | [
"DDInter776",
"DDInter1175"
] | Formoterol | Methotrimeprazine | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
480,
24,
9
]
],
[
[
480,
63,
1178
],
[
1178,
40,
9
]
],
[
[
480,
63,
1164
],
[
1164,
1,
9
]
],
[
[
480,
24,
401
],
[
401,
24,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles M... |
DB00405 | DB08815 | 128 | 154 | [
"DDInter517",
"DDInter1104"
] | Dexbrompheniramine | Lurasidone | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
128,
24,
154
]
],
[
[
128,
24,
1532
],
[
1532,
24,
154
]
],
[
[
128,
63,
1242
],
[
1242,
24,
154
]
],
[
[
128,
24,
1609
],
[
1609,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Cetir... |
DB01006 | DB01041 | 300 | 770 | [
"DDInter1040",
"DDInter1789"
] | Letrozole | Thalidomide | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
300,
25,
770
]
],
[
[
300,
21,
29425
],
[
29425,
60,
770
]
],
[
[
300,
24,
4
],
[
4,
63,
770
]
],
[
[
300,
63,
1335
],
[
1335,
2... | [
[
[
"Letrozole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Letrozole",
"{u} (Compound) causes {v} (Side Effect)",
"Myocardial ischaemia"
],
[
"Myocardial ischaemia",
"{u} (Side Effect) i... | Letrozole (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Thalidomide (Compound)
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction tha... |
DB00736 | DB12010 | 660 | 214 | [
"DDInter676",
"DDInter785"
] | Esomeprazole | Fostamatinib | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
660,
24,
214
]
],
[
[
660,
24,
976
],
[
976,
24,
214
]
],
[
[
660,
25,
1250
],
[
1250,
24,
214
]
],
[
[
660,
63,
600
],
[
600,
2... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Esomeprazole may lead to a major life threatening interaction when taken with Pazopanib and Pazopanib may ... |
DB00115 | DB00446 | 227 | 597 | [
"DDInter451",
"DDInter351"
] | Cyanocobalamin | Chloramphenicol | Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria, and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-, met... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
227,
24,
597
]
],
[
[
227,
1,
204
],
[
204,
24,
597
]
],
[
[
227,
6,
5805
],
[
5805,
45,
204
],
[
204,
24,
597
]
],
[
[
227,
1,
... | [
[
[
"Cyanocobalamin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Cyanocobalamin",
"{u} (Compound) resembles {v} (Compound)",
"Hydroxocobalamin"
],
[
"Hydroxocobalamin",
... | Cyanocobalamin (Compound) resembles Hydroxocobalamin (Compound) and Hydroxocobalamin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol
Cyanocobalamin (Compound) binds MTRR (Gene) and MTRR (Gene) is bound by Hydroxocobalamin (Compound) and Hydroxocobalamin may cause a modera... |
DB00353 | DB09073 | 588 | 951 | [
"DDInter1187",
"DDInter1379"
] | Methylergometrine | Palbociclib | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
588,
24,
951
]
],
[
[
588,
24,
1476
],
[
1476,
63,
951
]
],
[
[
588,
63,
600
],
[
600,
24,
951
]
],
[
[
588,
24,
578
],
[
578,
2... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Flucon... |
DB00214 | DB00374 | 1,028 | 1,061 | [
"DDInter1836",
"DDInter1852"
] | Torasemide | Treprostinil | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Moderate | 1 | [
[
[
1028,
24,
1061
]
],
[
[
1028,
24,
885
],
[
885,
40,
1061
]
],
[
[
1028,
6,
6017
],
[
6017,
45,
1061
]
],
[
[
1028,
7,
2592
],
[
2592,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Torasemide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Treprostinil (Compound)
Torasemide (Compound) upregulates CEBPD (Gene) and CEBPD (... |
DB00039 | DB00087 | 1,253 | 599 | [
"DDInter1380",
"DDInter41"
] | Palifermin | Alemtuzumab | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Moderate | 1 | [
[
[
1253,
24,
599
]
],
[
[
1253,
24,
281
],
[
281,
63,
599
]
],
[
[
1253,
24,
367
],
[
367,
24,
599
]
],
[
[
1253,
63,
268
],
[
268,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamisole"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Levamisole and Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1... |
DB06723 | DB11093 | 115 | 636 | [
"DDInter58",
"DDInter273"
] | Aluminum hydroxide | Calcium citrate | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Major | 2 | [
[
[
115,
25,
636
]
],
[
[
115,
62,
819
],
[
819,
24,
636
]
],
[
[
115,
63,
1572
],
[
1572,
24,
636
]
],
[
[
115,
25,
1436
],
[
1436,
... | [
[
[
"Aluminum hydroxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Calcium citrate"
]
],
[
[
"Aluminum hydroxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acebutolol"
],
... | Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Aluminum hydroxide may cause a moderate interaction that could exacerbate diseases when taken with De... |
DB01001 | DB11901 | 688 | 913 | [
"DDInter1632",
"DDInter107"
] | Salbutamol | Apalutamide | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
688,
24,
913
]
],
[
[
688,
62,
112
],
[
112,
23,
913
]
],
[
[
688,
23,
1247
],
[
1247,
23,
913
]
],
[
[
688,
63,
600
],
[
600,
2... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Salbutamol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and... |
DB01268 | DB14730 | 1,151 | 1,412 | [
"DDInter1731",
"DDInter264"
] | Sunitinib | Calaspargase pegol | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1151,
24,
1412
]
],
[
[
1151,
24,
792
],
[
792,
24,
1412
]
],
[
[
1151,
63,
1144
],
[
1144,
24,
1412
]
],
[
[
1151,
25,
868
],
[
868,
... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
],
... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide a... |
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