drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00704 | DB04896 | 267 | 901 | [
"DDInter1263",
"DDInter1220"
] | Naltrexone | Milnacipran | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
267,
24,
901
]
],
[
[
267,
64,
1349
],
[
1349,
40,
901
]
],
[
[
267,
21,
29271
],
[
29271,
60,
901
]
],
[
[
267,
24,
292
],
[
292,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meperidine"
],
[
"Meperidin... | Naltrexone may lead to a major life threatening interaction when taken with Meperidine and Meperidine (Compound) resembles Milnacipran (Compound)
Naltrexone (Compound) causes Migraine (Side Effect) and Migraine (Side Effect) is caused by Milnacipran (Compound)
Naltrexone may cause a moderate interaction that could exac... |
DB00074 | DB11601 | 1,309 | 1,270 | [
"DDInter166",
"DDInter1889"
] | Basiliximab | Tuberculin purified protein derivative | A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermenta... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1309,
24,
1270
]
],
[
[
1309,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
1309,
25,
1064
],
[
1064,
24,
1270
]
],
[
[
1309,
25,
1259
],
[
12... | [
[
[
"Basiliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Basiliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Basiliximab may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Basiliximab may lead to a major life threatening interaction when taken with Clad... |
DB00180 | DB00220 | 1,351 | 798 | [
"DDInter749",
"DDInter1276"
] | Flunisolide | Nelfinavir | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Moderate | 1 | [
[
[
1351,
24,
798
]
],
[
[
1351,
24,
215
],
[
215,
40,
798
]
],
[
[
1351,
24,
1327
],
[
1327,
1,
798
]
],
[
[
1351,
6,
8374
],
[
8374,
... | [
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
]
],
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indinavir"
],
[
... | Flunisolide may cause a moderate interaction that could exacerbate diseases when taken with Indinavir and Indinavir (Compound) resembles Nelfinavir (Compound)
Flunisolide may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Nelfinavir (Compound)
... |
DB00607 | DB09420 | 1,249 | 1,074 | [
"DDInter1256",
"DDInter953"
] | Nafcillin | Iodide I-123 | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1249,
24,
1074
]
],
[
[
1249,
40,
339
],
[
339,
24,
1074
]
],
[
[
1249,
25,
126
],
[
126,
24,
1074
]
],
[
[
1249,
1,
1681
],
[
1681,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Nafcillin",
"{u} (Compound) resembles {v} (Compound)",
"Bacampicillin"
],
[
"Bacampicillin",
"{u} may cause a m... | Nafcillin (Compound) resembles Bacampicillin (Compound) and Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Nafcillin may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate d... |
DB09322 | DB11943 | 1,114 | 255 | [
"DDInter1966",
"DDInter495"
] | Zinc sulfate | Delafloxacin | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1114,
24,
255
]
],
[
[
1114,
62,
1307
],
[
1307,
23,
255
]
],
[
[
1114,
62,
1596
],
[
1596,
24,
255
]
],
[
[
1114,
23,
428
],
[
428,
... | [
[
[
"Zinc sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Melphalan"
],
[... | Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Melphalan and Melphalan may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Iron and Iron may cause... |
DB08826 | DB08901 | 1,292 | 1,468 | [
"DDInter489",
"DDInter1492"
] | Deferiprone | Ponatinib | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
1292,
25,
1468
]
],
[
[
1292,
64,
478
],
[
478,
24,
1468
]
],
[
[
1292,
18,
7242
],
[
7242,
46,
1468
]
],
[
[
1292,
18,
2215
],
[
2215... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
"{u} ma... | Deferiprone may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Deferiprone (Compound) downregulates PHKA1 (Gene) and PHKA1 (Gene) is upregulated by Ponatinib (Compound)
Deferiprone (Compound) ... |
DB00206 | DB00852 | 1,245 | 1,445 | [
"DDInter1582",
"DDInter1545"
] | Reserpine | Pseudoephedrine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
1245,
24,
1445
]
],
[
[
1245,
63,
73
],
[
73,
24,
1445
]
],
[
[
1245,
24,
22
],
[
22,
40,
1445
]
],
[
[
1245,
21,
29434
],
[
29434,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
],
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ep... |
DB00668 | DB11827 | 874 | 433 | [
"DDInter652",
"DDInter669"
] | Epinephrine | Ertugliflozin | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
874,
24,
433
]
],
[
[
874,
63,
1121
],
[
1121,
24,
433
]
],
[
[
874,
24,
959
],
[
959,
24,
433
]
],
[
[
874,
40,
817
],
[
817,
2... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Gl... |
DB04896 | DB05773 | 901 | 1,047 | [
"DDInter1220",
"DDInter1848"
] | Milnacipran | Trastuzumab emtansine | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
901,
24,
1047
]
],
[
[
901,
63,
848
],
[
848,
24,
1047
]
],
[
[
901,
24,
1613
],
[
1613,
63,
1047
]
],
[
[
901,
64,
222
],
[
222,
... | [
[
[
"Milnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Milnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
... | Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Peginterfe... |
DB00554 | DB08820 | 1,027 | 1,478 | [
"DDInter1478",
"DDInter997"
] | Piroxicam | Ivacaftor | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1027,
24,
1478
]
],
[
[
1027,
6,
1829
],
[
1829,
45,
1478
]
],
[
[
1027,
24,
1411
],
[
1411,
24,
1478
]
],
[
[
1027,
63,
245
],
[
245,... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Piroxicam",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
"I... | Piroxicam (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ivacaftor (Compound)
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor
Piroxicam may cause a mode... |
DB00344 | DB13074 | 1,302 | 877 | [
"DDInter1543",
"DDInter1110"
] | Protriptyline | Macimorelin | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1302,
25,
877
]
],
[
[
1302,
23,
112
],
[
112,
23,
877
]
],
[
[
1302,
24,
85
],
[
85,
24,
877
]
],
[
[
1302,
40,
1236
],
[
1236,
... | [
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Protriptyline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Me... | Protriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Atropine and... |
DB00743 | DB01210 | 808 | 668 | [
"DDInter792",
"DDInter1050"
] | Gadobenic acid | Levobunolol (ophthalmic) | Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity. As gadob... | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Moderate | 1 | [
[
[
808,
24,
668
]
],
[
[
808,
63,
461
],
[
461,
1,
668
]
],
[
[
808,
24,
887
],
[
887,
1,
668
]
],
[
[
808,
24,
699
],
[
699,
40,
... | [
[
[
"Gadobenic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levobunolol"
]
],
[
[
"Gadobenic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
... | Gadobenic acid may cause a moderate interaction that could exacerbate diseases when taken with Levobunolol
Gadobenic acid may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Levobunolol (Compound)
Gadobenic acid may cause a moderate interaction that c... |
DB00604 | DB00703 | 1,425 | 997 | [
"DDInter385",
"DDInter1167"
] | Cisapride | Methazolamide | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Major | 2 | [
[
[
1425,
25,
997
]
],
[
[
1425,
25,
471
],
[
471,
1,
997
]
],
[
[
1425,
6,
6017
],
[
6017,
45,
997
]
],
[
[
1425,
25,
1662
],
[
1662,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methazolamide"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetazolamide"
],
[
"Acetazolamide",
... | Cisapride may lead to a major life threatening interaction when taken with Acetazolamide and Acetazolamide (Compound) resembles Methazolamide (Compound)
Cisapride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Methazolamide (Compound)
Cisapride may lead to a major life threatening interaction when taken w... |
DB01068 | DB06273 | 1,565 | 980 | [
"DDInter411",
"DDInter1824"
] | Clonazepam | Tocilizumab | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1565,
24,
980
]
],
[
[
1565,
62,
1031
],
[
1031,
24,
980
]
],
[
[
1565,
63,
629
],
[
629,
24,
980
]
],
[
[
1565,
24,
384
],
[
384,
... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Clonazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Theophylline"
],
[
... | Clonazepam may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Siro... |
DB00999 | DB09135 | 504 | 1,211 | [
"DDInter883",
"DDInter967"
] | Hydrochlorothiazide | Ioxilan | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
504,
24,
1211
]
],
[
[
504,
1,
323
],
[
323,
24,
1211
]
],
[
[
504,
63,
1648
],
[
1648,
24,
1211
]
],
[
[
504,
40,
178
],
[
178,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Hydrochlorothiazide",
"{u} (Compound) resembles {v} (Compound)",
"Bendroflumethiazide"
],
[
"Bendroflumethiazide... | Hydrochlorothiazide (Compound) resembles Bendroflumethiazide (Compound) and Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may caus... |
DB00773 | DB12095 | 896 | 179 | [
"DDInter702",
"DDInter1760"
] | Etoposide | Telotristat ethyl | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
896,
24,
179
]
],
[
[
896,
63,
79
],
[
79,
24,
179
]
],
[
[
896,
24,
310
],
[
310,
24,
179
]
],
[
[
896,
24,
283
],
[
283,
63,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Ca... |
DB00968 | DB01067 | 1,551 | 959 | [
"DDInter1185",
"DDInter826"
] | Methyldopa | Glipizide | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Minor | 0 | [
[
[
1551,
23,
959
]
],
[
[
1551,
62,
245
],
[
245,
40,
959
]
],
[
[
1551,
23,
1411
],
[
1411,
1,
959
]
],
[
[
1551,
18,
4789
],
[
4789,
... | [
[
[
"Methyldopa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Glipizide"
]
],
[
[
"Methyldopa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Glimepiride"
],
[
... | Methyldopa may cause a minor interaction that can limit clinical effects when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Methyldopa may cause a minor interaction that can limit clinical effects when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
Me... |
DB00316 | DB00863 | 474 | 1,194 | [
"DDInter14",
"DDInter1568"
] | Acetaminophen | Ranitidine | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Minor | 0 | [
[
[
474,
23,
1194
]
],
[
[
474,
6,
8374
],
[
8374,
45,
1194
]
],
[
[
474,
21,
28701
],
[
28701,
60,
1194
]
],
[
[
474,
24,
126
],
[
126,
... | [
[
[
"Acetaminophen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
]
],
[
[
"Acetaminophen",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Acetaminophen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ranitidine (Compound)
Acetaminophen (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Ranitidine (Compound)
Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Warfarin... |
DB08865 | DB12500 | 1,593 | 283 | [
"DDInter448",
"DDInter714"
] | Crizotinib | Fedratinib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Minor | 0 | [
[
[
1593,
23,
283
]
],
[
[
1593,
23,
271
],
[
271,
23,
283
]
],
[
[
1593,
23,
466
],
[
466,
62,
283
]
],
[
[
1593,
25,
351
],
[
351,
... | [
[
[
"Crizotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fedratinib"
]
],
[
[
"Crizotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Crizotinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Crizotinib may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutami... |
DB00424 | DB00986 | 19 | 1,192 | [
"DDInter896",
"DDInter834"
] | Hyoscyamine | Glycopyrronium | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
19,
24,
1192
]
],
[
[
19,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
19,
24,
262
],
[
262,
24,
1192
]
],
[
[
19,
40,
11389
],
[
11389,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and... |
DB00872 | DB12010 | 1,080 | 214 | [
"DDInter438",
"DDInter785"
] | Conivaptan | Fostamatinib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
1080,
25,
214
]
],
[
[
1080,
25,
976
],
[
976,
24,
214
]
],
[
[
1080,
63,
723
],
[
723,
24,
214
]
],
[
[
1080,
24,
973
],
[
973,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
"{... | Conivaptan may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may ca... |
DB06764 | DB09241 | 1,090 | 1,629 | [
"DDInter1787",
"DDInter1186"
] | Tetryzoline (nasal) | Methylene blue | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1090,
37,
1629
]
],
[
[
1090,
63,
1052
],
[
1052,
24,
1629
]
],
[
[
1090,
24,
1032
],
[
1032,
63,
1629
]
],
[
[
1090,
24,
659
],
[
659... | [
[
[
"Tetryzoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Tetryzoline",
"{u} may cause a moderate interaction that... | Tetryzoline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue and Tetryzoline may lead to a major life threatening interaction when taken with Methylene blue
Tetryzoline may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine m... |
DB00683 | DB01377 | 1,382 | 1,283 | [
"DDInter1212",
"DDInter1119"
] | Midazolam | Magnesium oxide | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
1382,
23,
1283
]
],
[
[
1382,
62,
1573
],
[
1573,
23,
1283
]
],
[
[
1382,
1,
905
],
[
905,
23,
1283
]
],
[
[
1382,
24,
104
],
[
104,
... | [
[
[
"Midazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Midazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisone"
],
[
... | Midazolam may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Midazolam (Compound) resembles Lorazepam (Compound) and Lorazepam may cause a minor interaction that can limit c... |
DB00903 | DB09268 | 1,680 | 1,662 | [
"DDInter686",
"DDInter1464"
] | Etacrynic acid | Picosulfuric acid | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1680,
24,
1662
]
],
[
[
1680,
63,
91
],
[
91,
24,
1662
]
],
[
[
1680,
24,
708
],
[
708,
24,
1662
]
],
[
[
1680,
25,
361
],
[
361,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Cortic... |
DB00215 | DB00574 | 1,230 | 121 | [
"DDInter388",
"DDInter717"
] | Citalopram | Fenfluramine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Major | 2 | [
[
[
1230,
25,
121
]
],
[
[
1230,
24,
1144
],
[
1144,
63,
121
]
],
[
[
1230,
63,
366
],
[
366,
24,
121
]
],
[
[
1230,
24,
291
],
[
291,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
"Nategli... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Eptifibatide and ... |
DB00305 | DB08913 | 377 | 1,186 | [
"DDInter1232",
"DDInter1561"
] | Mitomycin | Radium Ra 223 dichloride | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
377,
24,
1186
]
],
[
[
377,
21,
28872
],
[
28872,
60,
1186
]
],
[
[
377,
24,
37
],
[
37,
24,
1186
]
],
[
[
377,
24,
1362
],
[
1362,
... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Mitomycin",
"{u} (Compound) causes {v} (Side Effect)",
"Extravasation"
],
[
"Extravasation",
"{u} (... | Mitomycin (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when ... |
DB00374 | DB09112 | 1,061 | 1,455 | [
"DDInter1852",
"DDInter1306"
] | Treprostinil | Nitrous acid | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
1061,
24,
1455
]
],
[
[
1061,
24,
312
],
[
312,
24,
1455
]
],
[
[
1061,
63,
1000
],
[
1000,
24,
1455
]
],
[
[
1061,
1,
885
],
[
885,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Guanadrel and G... |
DB12141 | DB12941 | 971 | 466 | [
"DDInter817",
"DDInter481"
] | Gilteritinib | Darolutamide | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
971,
23,
466
]
],
[
[
971,
64,
1622
],
[
1622,
23,
466
]
],
[
[
971,
63,
34
],
[
34,
23,
466
]
],
[
[
971,
24,
283
],
[
283,
23,... | [
[
[
"Gilteritinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Gilteritinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Vori... | Gilteritinib may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprena... |
DB00700 | DB11730 | 312 | 351 | [
"DDInter656",
"DDInter1588"
] | Eplerenone | Ribociclib | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
312,
25,
351
]
],
[
[
312,
25,
283
],
[
283,
62,
351
]
],
[
[
312,
1,
1561
],
[
1561,
24,
351
]
],
[
[
312,
24,
1486
],
[
1486,
... | [
[
[
"Eplerenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Eplerenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"{u} m... | Eplerenone may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Eplerenone (Compound) resembles Testosterone (Compound) and Testosterone may cause a moderate interaction that could exacerbate d... |
DB00286 | DB01284 | 380 | 1,042 | [
"DDInter439",
"DDInter1782"
] | Conjugated estrogens | Tetracosactide | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
380,
24,
1042
]
],
[
[
380,
23,
771
],
[
771,
62,
1042
]
],
[
[
380,
24,
761
],
[
761,
63,
1042
]
],
[
[
380,
40,
559
],
[
559,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyalu... | Conjugated estrogens may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00047 | DB00595 | 176 | 1,545 | [
"DDInter932",
"DDInter1374"
] | Insulin glargine | Oxytetracycline | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Moderate | 1 | [
[
[
176,
24,
1545
]
],
[
[
176,
24,
964
],
[
964,
1,
1545
]
],
[
[
176,
24,
471
],
[
471,
62,
1545
]
],
[
[
176,
24,
1028
],
[
1028,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxytetracycline"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycyclin... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Oxytetracycline (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Acetazolamide and Acetazolamide may cause a minor ... |
DB13074 | DB14509 | 877 | 1,399 | [
"DDInter1110",
"DDInter1081"
] | Macimorelin | Lithium carbonate | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
877,
25,
1399
]
],
[
[
877,
63,
1479
],
[
1479,
23,
1399
]
],
[
[
877,
64,
1374
],
[
1374,
24,
1399
]
],
[
[
877,
63,
129
],
[
129,
... | [
[
[
"Macimorelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Macimorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
... | Macimorelin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Macimorelin may lead to a major life threatening interaction when taken with Abiratero... |
DB01041 | DB08908 | 770 | 713 | [
"DDInter1789",
"DDInter564"
] | Thalidomide | Dimethyl fumarate | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
770,
24,
713
]
],
[
[
770,
24,
996
],
[
996,
24,
713
]
],
[
[
770,
25,
60
],
[
60,
24,
713
]
],
[
[
770,
64,
552
],
[
552,
24,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Thalidomide may lead to a major life threatening interaction when taken with Capecitabine and Capecita... |
DB00005 | DB01097 | 1,057 | 1,377 | [
"DDInter687",
"DDInter1033"
] | Etanercept | Leflunomide | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1057,
25,
1377
]
],
[
[
1057,
23,
1461
],
[
1461,
23,
1377
]
],
[
[
1057,
23,
1193
],
[
1193,
62,
1377
]
],
[
[
1057,
24,
949
],
[
949... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Leflunomide
Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluc... |
DB00180 | DB04865 | 1,351 | 4 | [
"DDInter749",
"DDInter1335"
] | Flunisolide | Omacetaxine mepesuccinate | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1351,
24,
4
]
],
[
[
1351,
18,
3169
],
[
3169,
46,
4
]
],
[
[
1351,
7,
3163
],
[
3163,
46,
4
]
],
[
[
1351,
6,
1899
],
[
1899,
4... | [
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Flunisolide",
"{u} (Compound) downregulates {v} (Gene)",
"SQSTM1"
],
[
"SQSTM1",
"{u} (Gene) is ... | Flunisolide (Compound) downregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Flunisolide (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Flunisolide (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is upregulate... |
DB00344 | DB01169 | 1,302 | 57 | [
"DDInter1543",
"DDInter120"
] | Protriptyline | Arsenic trioxide | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1302,
25,
57
]
],
[
[
1302,
6,
4973
],
[
4973,
45,
57
]
],
[
[
1302,
23,
112
],
[
112,
23,
57
]
],
[
[
1302,
24,
480
],
[
480,
2... | [
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Protriptyline",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Protriptyline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Arsenic trioxide (Compound)
Protriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
... |
DB01133 | DB14491 | 1,104 | 428 | [
"DDInter1808",
"DDInter725"
] | Tiludronic acid | Ferrous fumarate | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
1104,
24,
428
]
],
[
[
1104,
24,
1193
],
[
1193,
23,
428
]
],
[
[
1104,
24,
115
],
[
115,
24,
428
]
],
[
[
1104,
24,
1193
],
[
1193,
... | [
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc glucon... | Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00759 | DB01021 | 1,620 | 674 | [
"DDInter1783",
"DDInter1861"
] | Tetracycline | Trichlormethiazide | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Minor | 0 | [
[
[
1620,
23,
674
]
],
[
[
1620,
62,
1014
],
[
1014,
40,
674
]
],
[
[
1620,
23,
178
],
[
178,
1,
674
]
],
[
[
1620,
23,
359
],
[
359,
... | [
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Benzthiazide"
]... | Tetracycline may cause a minor interaction that can limit clinical effects when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Tetracycline may cause a minor interaction that can limit clinical effects when taken with Polythiazide and Polythiazide (Compound) resembles Trichl... |
DB00502 | DB01364 | 1,300 | 22 | [
"DDInter853",
"DDInter650"
] | Haloperidol | Ephedrine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1300,
24,
22
]
],
[
[
1300,
21,
28730
],
[
28730,
60,
22
]
],
[
[
1300,
64,
475
],
[
475,
23,
22
]
],
[
[
1300,
24,
688
],
[
688,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Haloperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Psychotic disorder"
],
[
"Psychotic disorder",
"{u} (S... | Haloperidol (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Ephedrine (Compound)
Haloperidol may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a minor interaction that can limit clinical effects when taken with Ephedrine... |
DB01211 | DB12161 | 609 | 730 | [
"DDInter393",
"DDInter512"
] | Clarithromycin | Deutetrabenazine | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
609,
24,
730
]
],
[
[
609,
62,
112
],
[
112,
23,
730
]
],
[
[
609,
63,
322
],
[
322,
24,
730
]
],
[
[
609,
25,
971
],
[
971,
24,... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Epiru... |
DB01611 | DB13179 | 1,487 | 68 | [
"DDInter893",
"DDInter1882"
] | Hydroxychloroquine | Troleandomycin | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
1487,
24,
68
]
],
[
[
1487,
24,
1374
],
[
1374,
23,
68
]
],
[
[
1487,
24,
309
],
[
309,
24,
68
]
],
[
[
1487,
63,
973
],
[
973,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abirate... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with I... |
DB04845 | DB05773 | 309 | 1,047 | [
"DDInter1001",
"DDInter1848"
] | Ixabepilone | Trastuzumab emtansine | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
309,
24,
1047
]
],
[
[
309,
63,
1091
],
[
1091,
24,
1047
]
],
[
[
309,
25,
375
],
[
375,
63,
1047
]
],
[
[
309,
24,
381
],
[
381,
... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Ixabepilone may lead to a major life threatening interaction when taken with Certolizumab pegol and ... |
DB00635 | DB01072 | 1,573 | 915 | [
"DDInter1515",
"DDInter129"
] | Prednisone | Atazanavir | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Moderate | 1 | [
[
[
1573,
24,
915
]
],
[
[
1573,
24,
1327
],
[
1327,
1,
915
]
],
[
[
1573,
6,
4973
],
[
4973,
45,
915
]
],
[
[
1573,
21,
29051
],
[
29051,... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atazanavir"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Prednisone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atazanavir (Compound)
Prednisone (Compound) causes Fluid retention (Side Effect) and Fluid... |
DB00911 | DB14723 | 458 | 159 | [
"DDInter1811",
"DDInter1026"
] | Tinidazole | Larotrectinib | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
458,
24,
159
]
],
[
[
458,
24,
1375
],
[
1375,
24,
159
]
],
[
[
458,
63,
63
],
[
63,
24,
159
]
],
[
[
458,
24,
1654
],
[
1654,
6... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Tenip... |
DB00350 | DB01234 | 1,214 | 1,220 | [
"DDInter1226",
"DDInter513"
] | Minoxidil | Dexamethasone | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1214,
24,
1220
]
],
[
[
1214,
24,
870
],
[
870,
1,
1220
]
],
[
[
1214,
24,
175
],
[
175,
40,
1220
]
],
[
[
1214,
7,
2384
],
[
2384,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexam... |
DB00708 | DB00986 | 1,454 | 1,192 | [
"DDInter1718",
"DDInter834"
] | Sufentanil | Glycopyrronium | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
1454,
24,
1192
]
],
[
[
1454,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
1454,
24,
262
],
[
262,
24,
1192
]
],
[
[
1454,
21,
28746
],
[
287... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and C... |
DB06663 | DB09472 | 1,154 | 1,383 | [
"DDInter1398",
"DDInter1693"
] | Pasireotide | Sodium sulfate | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1154,
24,
1383
]
],
[
[
1154,
63,
1482
],
[
1482,
23,
1383
]
],
[
[
1154,
64,
609
],
[
609,
24,
1383
]
],
[
[
1154,
24,
1613
],
[
1613... | [
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
],
... | Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Sodium sulfate
Pasireotide may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin ... |
DB00281 | DB01172 | 608 | 416 | [
"DDInter1066",
"DDInter1004"
] | Lidocaine | Kanamycin | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Minor | 0 | [
[
[
608,
23,
416
]
],
[
[
608,
21,
29323
],
[
29323,
60,
416
]
],
[
[
608,
24,
699
],
[
699,
62,
416
]
],
[
[
608,
23,
998
],
[
998,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Kanamycin"
]
],
[
[
"Lidocaine",
"{u} (Compound) causes {v} (Side Effect)",
"Paralysis"
],
[
"Paralysis",
"{u} (Side Effect) is caused by... | Lidocaine (Compound) causes Paralysis (Side Effect) and Paralysis (Side Effect) is caused by Kanamycin (Compound)
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol may cause a minor interaction that can limit clinical effects when taken with Kanamycin
Lidocain... |
DB00086 | DB00881 | 1,167 | 954 | [
"DDInter1712",
"DDInter1554"
] | Streptokinase | Quinapril | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
1167,
24,
954
]
],
[
[
1167,
24,
1638
],
[
1638,
1,
954
]
],
[
[
1167,
25,
365
],
[
365,
63,
954
]
],
[
[
1167,
24,
885
],
[
885,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Streptokinase may lead to a major life threatening interaction when taken with Dalteparin and Dalteparin may cause a moderate interaction that could exace... |
DB01068 | DB08820 | 1,565 | 1,478 | [
"DDInter411",
"DDInter997"
] | Clonazepam | Ivacaftor | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1565,
24,
1478
]
],
[
[
1565,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1565,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
1565,
24,
1040
],
[
1... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Clonazepam",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Clonazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Clonazepam (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafen... |
DB01059 | DB11978 | 956 | 124 | [
"DDInter1313",
"DDInter822"
] | Norfloxacin | Glasdegib | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
956,
24,
124
]
],
[
[
956,
62,
112
],
[
112,
23,
124
]
],
[
[
956,
63,
79
],
[
79,
24,
124
]
],
[
[
956,
40,
739
],
[
739,
24,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Norfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sora... |
DB01197 | DB13620 | 1,603 | 948 | [
"DDInter292",
"DDInter1499"
] | Captopril | Potassium gluconate | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Major | 2 | [
[
[
1603,
25,
948
]
],
[
[
1603,
63,
176
],
[
176,
23,
948
]
],
[
[
1603,
24,
1254
],
[
1254,
23,
948
]
],
[
[
1603,
63,
848
],
[
848,
... | [
[
[
"Captopril",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
],
[
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Potassium gluconate
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Insu... |
DB01320 | DB11703 | 651 | 405 | [
"DDInter783",
"DDInter9"
] | Fosphenytoin | Acalabrutinib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
651,
25,
405
]
],
[
[
651,
63,
1324
],
[
1324,
24,
405
]
],
[
[
651,
62,
1101
],
[
1101,
24,
405
]
],
[
[
651,
25,
951
],
[
951,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
"T... | Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Fosphenytoin may cause a minor interaction that can limit clinical effects when taken with Bexarotene a... |
DB00855 | DB01015 | 213 | 1,247 | [
"DDInter72",
"DDInter1724"
] | Aminolevulinic acid | Sulfamethoxazole | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Major | 2 | [
[
[
213,
25,
1247
]
],
[
[
213,
64,
1029
],
[
1029,
1,
1247
]
],
[
[
213,
21,
28658
],
[
28658,
60,
1247
]
],
[
[
213,
25,
918
],
[
918,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfisoxazole"
],
[
... | Aminolevulinic acid may lead to a major life threatening interaction when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound)
Aminolevulinic acid (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Sulfamethoxazole (Compound)
Aminolevulinic acid may l... |
DB08865 | DB09073 | 1,593 | 951 | [
"DDInter448",
"DDInter1379"
] | Crizotinib | Palbociclib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1593,
24,
951
]
],
[
[
1593,
23,
907
],
[
907,
62,
951
]
],
[
[
1593,
64,
318
],
[
318,
23,
951
]
],
[
[
1593,
23,
271
],
[
271,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Crizotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[
... | Crizotinib may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Crizotinib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause... |
DB01015 | DB01259 | 1,247 | 392 | [
"DDInter1724",
"DDInter1024"
] | Sulfamethoxazole | Lapatinib | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Minor | 0 | [
[
[
1247,
23,
392
]
],
[
[
1247,
6,
8374
],
[
8374,
45,
392
]
],
[
[
1247,
18,
10375
],
[
10375,
57,
392
]
],
[
[
1247,
21,
29429
],
[
294... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lapatinib"
]
],
[
[
"Sulfamethoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Sulfamethoxazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Sulfamethoxazole (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Lapatinib (Compound)
Sulfamethoxazole (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caus... |
DB00907 | DB01242 | 290 | 1,237 | [
"DDInter427",
"DDInter410"
] | Cocaine (topical) | Clomipramine | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Major | 2 | [
[
[
290,
25,
1237
]
],
[
[
290,
64,
1164
],
[
1164,
1,
1237
]
],
[
[
290,
6,
12523
],
[
12523,
45,
1237
]
],
[
[
290,
21,
29083
],
[
29083... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomipramine"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimipramine"
],
[
"Trimipramine",
"{u} (... | Cocaine may lead to a major life threatening interaction when taken with Clomipramine
Cocaine may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)
Cocaine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Clomipramine (Com... |
DB00582 | DB01268 | 1,622 | 1,151 | [
"DDInter1946",
"DDInter1731"
] | Voriconazole | Sunitinib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1622,
24,
1151
]
],
[
[
1622,
6,
6799
],
[
6799,
45,
1151
]
],
[
[
1622,
21,
29487
],
[
29487,
60,
1151
]
],
[
[
1622,
23,
112
],
[
11... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7"
],
[
"CYP3A7",
"{u} (Gene) is bound by {v} (Compound... | Voriconazole (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Sunitinib (Compound)
Voriconazole (Compound) causes Cholecystitis (Side Effect) and Cholecystitis (Side Effect) is caused by Sunitinib (Compound)
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Metronida... |
DB00364 | DB01165 | 417 | 1,539 | [
"DDInter1717",
"DDInter1325"
] | Sucralfate | Ofloxacin | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
417,
24,
1539
]
],
[
[
417,
24,
1467
],
[
1467,
1,
1539
]
],
[
[
417,
63,
1176
],
[
1176,
1,
1539
]
],
[
[
417,
24,
945
],
[
945,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxacin"
],
[
... | Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Su... |
DB01203 | DB11126 | 699 | 900 | [
"DDInter1255",
"DDInter276"
] | Nadolol | Calcium gluconate | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
699,
24,
900
]
],
[
[
699,
40,
729
],
[
729,
24,
900
]
],
[
[
699,
62,
542
],
[
542,
24,
900
]
],
[
[
699,
40,
729
],
[
729,
40,... | [
[
[
"Nadolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Nadolol",
"{u} (Compound) resembles {v} (Compound)",
"Penbutolol"
],
[
"Penbutolol",
"{u} may cause a modera... | Nadolol (Compound) resembles Penbutolol (Compound) and Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Nadolol may cause a minor interaction that can limit clinical effects when taken with Levothyroxine and Levothyroxine may cause a moderate interaction that ... |
DB00451 | DB00550 | 542 | 99 | [
"DDInter1064",
"DDInter1541"
] | Levothyroxine | Propylthiouracil | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Moderate | 1 | [
[
[
542,
24,
99
]
],
[
[
542,
7,
7273
],
[
7273,
46,
99
]
],
[
[
542,
18,
2183
],
[
2183,
57,
99
]
],
[
[
542,
21,
28957
],
[
28957,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propylthiouracil"
]
],
[
[
"Levothyroxine",
"{u} (Compound) upregulates {v} (Gene)",
"GPATCH8"
],
[
"GPATCH8",
"{u} (Gene) is upreg... | Levothyroxine (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Propylthiouracil (Compound)
Levothyroxine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Propylthiouracil (Compound)
Levothyroxine (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) ... |
DB01276 | DB11943 | 123 | 255 | [
"DDInter706",
"DDInter495"
] | Exenatide | Delafloxacin | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
123,
24,
255
]
],
[
[
123,
63,
589
],
[
589,
23,
255
]
],
[
[
123,
63,
1512
],
[
1512,
24,
255
]
],
[
[
123,
24,
1476
],
[
1476,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac... |
DB00734 | DB01128 | 1,664 | 918 | [
"DDInter1605",
"DDInter204"
] | Risperidone | Bicalutamide | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
1664,
24,
918
]
],
[
[
1664,
24,
129
],
[
129,
40,
918
]
],
[
[
1664,
6,
8374
],
[
8374,
45,
918
]
],
[
[
1664,
21,
29666
],
[
29666,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Risperidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Risperidone (Compound) causes Melaena (Side Effect) and ... |
DB00850 | DB13074 | 1,630 | 877 | [
"DDInter1432",
"DDInter1110"
] | Perphenazine | Macimorelin | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1630,
25,
877
]
],
[
[
1630,
23,
112
],
[
112,
23,
877
]
],
[
[
1630,
63,
85
],
[
85,
24,
877
]
],
[
[
1630,
1,
673
],
[
673,
24... | [
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Perphenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Perphenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and A... |
DB08864 | DB09073 | 786 | 951 | [
"DDInter1595",
"DDInter1379"
] | Rilpivirine | Palbociclib | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
786,
24,
951
]
],
[
[
786,
24,
1476
],
[
1476,
63,
951
]
],
[
[
786,
25,
351
],
[
351,
63,
951
]
],
[
[
786,
63,
600
],
[
600,
2... | [
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[... | Rilpivirine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Rilpivirine may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cau... |
DB00342 | DB01059 | 1,181 | 956 | [
"DDInter1770",
"DDInter1313"
] | Terfenadine | Norfloxacin | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
1181,
24,
956
]
],
[
[
1181,
24,
872
],
[
872,
40,
956
]
],
[
[
1181,
64,
1176
],
[
1176,
1,
956
]
],
[
[
1181,
24,
1539
],
[
1539,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Terfenadine may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Ter... |
DB00163 | DB15091 | 1,461 | 676 | [
"DDInter1943",
"DDInter1901"
] | Vitamin E | Upadacitinib | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Minor | 0 | [
[
[
1461,
23,
676
]
],
[
[
1461,
62,
1184
],
[
1184,
25,
676
]
],
[
[
1461,
23,
891
],
[
891,
25,
676
]
],
[
[
1461,
24,
869
],
[
869,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Upadacitinib"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Anakinra"
],
[
"A... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Anakinra and Anakinra may lead to a major life threatening interaction when taken with Upadacitinib
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Prednisolone and Prednisolone may lead to a ... |
DB01132 | DB09054 | 1,130 | 384 | [
"DDInter1472",
"DDInter905"
] | Pioglitazone | Idelalisib | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1130,
24,
384
]
],
[
[
1130,
63,
222
],
[
222,
23,
384
]
],
[
[
1130,
24,
1627
],
[
1627,
62,
384
]
],
[
[
1130,
62,
307
],
[
307,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and C... |
DB01030 | DB10795 | 869 | 221 | [
"DDInter1835",
"DDInter1486"
] | Topotecan | Poliovirus type 1 antigen (formaldehyde inactivated) | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
869,
24,
221
]
],
[
[
869,
24,
36
],
[
36,
24,
221
]
],
[
[
869,
64,
581
],
[
581,
24,
221
]
],
[
[
869,
63,
599
],
[
599,
24,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Topotecan may lead to a major life threatening interaction when taken with ... |
DB00069 | DB00307 | 367 | 1,101 | [
"DDInter946",
"DDInter202"
] | Interferon alfacon-1 | Bexarotene | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Major | 2 | [
[
[
367,
25,
1101
]
],
[
[
367,
24,
597
],
[
597,
62,
1101
]
],
[
[
367,
24,
168
],
[
168,
23,
1101
]
],
[
[
367,
63,
1253
],
[
1253,
... | [
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when take... |
DB01319 | DB09564 | 34 | 1,296 | [
"DDInter777",
"DDInter930"
] | Fosamprenavir | Insulin degludec | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
34,
24,
1296
]
],
[
[
34,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
34,
24,
659
],
[
659,
24,
1296
]
],
[
[
34,
64,
175
],
[
175,
24... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Vilante... |
DB00500 | DB06228 | 24 | 792 | [
"DDInter1831",
"DDInter1609"
] | Tolmetin | Rivaroxaban | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
24,
25,
792
]
],
[
[
24,
21,
28647
],
[
28647,
60,
792
]
],
[
[
24,
23,
752
],
[
752,
24,
792
]
],
[
[
24,
24,
738
],
[
738,
63,... | [
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Tolmetin",
"{u} (Compound) causes {v} (Side Effect)",
"Urinary tract infection"
],
[
"Urinary tract infection",
"{u} (Side Effec... | Tolmetin (Compound) causes Urinary tract infection (Side Effect) and Urinary tract infection (Side Effect) is caused by Rivaroxaban (Compound)
Tolmetin may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a moderate interaction that could exacerbate diseases ... |
DB00283 | DB01114 | 701 | 272 | [
"DDInter395",
"DDInter362"
] | Clemastine | Chlorpheniramine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
701,
24,
272
]
],
[
[
701,
24,
358
],
[
358,
63,
272
]
],
[
[
701,
1,
11268
],
[
11268,
1,
272
]
],
[
[
701,
24,
128
],
[
128,
2... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Clemastine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Chlorphe... |
DB00197 | DB00530 | 1,324 | 1,195 | [
"DDInter1881",
"DDInter667"
] | Troglitazone | Erlotinib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Moderate | 1 | [
[
[
1324,
24,
1195
]
],
[
[
1324,
24,
883
],
[
883,
40,
1195
]
],
[
[
1324,
24,
307
],
[
307,
62,
1195
]
],
[
[
1324,
24,
122
],
[
122,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Erlotinib (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit... |
DB00572 | DB00909 | 85 | 306 | [
"DDInter136",
"DDInter1971"
] | Atropine | Zonisamide | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Major | 2 | [
[
[
85,
25,
306
]
],
[
[
85,
21,
28691
],
[
28691,
60,
306
]
],
[
[
85,
24,
407
],
[
407,
63,
306
]
],
[
[
85,
63,
475
],
[
475,
24,... | [
[
[
"Atropine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zonisamide"
]
],
[
[
"Atropine",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is caused by {v} (Compou... | Atropine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Zonisamide (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Zonisamide
Atropine... |
DB00277 | DB00550 | 1,031 | 99 | [
"DDInter1791",
"DDInter1541"
] | Theophylline | Propylthiouracil | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Moderate | 1 | [
[
[
1031,
24,
99
]
],
[
[
1031,
21,
28787
],
[
28787,
60,
99
]
],
[
[
1031,
24,
320
],
[
320,
63,
99
]
],
[
[
1031,
25,
772
],
[
772,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propylthiouracil"
]
],
[
[
"Theophylline",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Eff... | Theophylline (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Propylthiouracil (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Thyroid, porcine and Thyroid, porcine may cause a moderate interaction that could exacerbate diseases... |
DB00023 | DB00339 | 305 | 1,182 | [
"DDInter127",
"DDInter1547"
] | Asparaginase Escherichia coli | Pyrazinamide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A pyrazine that is used therapeutically as an antitubercular agent. | Moderate | 1 | [
[
[
305,
24,
1182
]
],
[
[
305,
24,
384
],
[
384,
63,
1182
]
],
[
[
305,
24,
912
],
[
912,
24,
1182
]
],
[
[
305,
25,
1510
],
[
1510,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pyrazinamide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Pyrazinamide
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseas... |
DB08865 | DB15822 | 1,593 | 69 | [
"DDInter448",
"DDInter1504"
] | Crizotinib | Pralsetinib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
1593,
24,
69
]
],
[
[
1593,
23,
283
],
[
283,
24,
69
]
],
[
[
1593,
64,
1213
],
[
1213,
24,
69
]
],
[
[
1593,
25,
985
],
[
985,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Crizotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fedratinib"
],
[
... | Crizotinib may cause a minor interaction that can limit clinical effects when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Crizotinib may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a m... |
DB00450 | DB00938 | 78 | 455 | [
"DDInter603",
"DDInter1635"
] | Droperidol | Salmeterol | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
78,
24,
455
]
],
[
[
78,
24,
688
],
[
688,
63,
455
]
],
[
[
78,
21,
29024
],
[
29024,
60,
455
]
],
[
[
78,
25,
167
],
[
167,
23,... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Droperidol (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Salmeterol (... |
DB09293 | DB14509 | 116 | 1,399 | [
"DDInter954",
"DDInter1081"
] | Iodide I-131 | Lithium carbonate | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
116,
24,
1399
]
],
[
[
116,
63,
1479
],
[
1479,
23,
1399
]
],
[
[
116,
63,
820
],
[
820,
24,
1399
]
],
[
[
116,
63,
1527
],
[
1527,
... | [
[
[
"Iodide I-131",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Iodide I-131",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic ... | Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Iodide I-131 may cause a moderate interaction that could exacerbate diseases when tak... |
DB00968 | DB01143 | 1,551 | 923 | [
"DDInter1185",
"DDInter65"
] | Methyldopa | Amifostine | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1551,
24,
923
]
],
[
[
1551,
7,
12097
],
[
12097,
46,
923
]
],
[
[
1551,
21,
28680
],
[
28680,
60,
923
]
],
[
[
1551,
1,
1266
],
[
126... | [
[
[
"Methyldopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Methyldopa",
"{u} (Compound) upregulates {v} (Gene)",
"ERAP2"
],
[
"ERAP2",
"{u} (Gene) is upregulated by {v} (C... | Methyldopa (Compound) upregulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Amifostine (Compound)
Methyldopa (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Amifostine (Compound)
Methyldopa (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that cou... |
DB06589 | DB09073 | 1,250 | 951 | [
"DDInter1400",
"DDInter1379"
] | Pazopanib | Palbociclib | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1250,
24,
951
]
],
[
[
1250,
23,
907
],
[
907,
62,
951
]
],
[
[
1250,
64,
318
],
[
318,
23,
951
]
],
[
[
1250,
62,
479
],
[
479,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Pazopanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[
... | Pazopanib may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Pazopanib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a... |
DB00795 | DB05528 | 50 | 1,070 | [
"DDInter1725",
"DDInter1228"
] | Sulfasalazine | Mipomersen | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
50,
25,
1070
]
],
[
[
50,
63,
1512
],
[
1512,
25,
1070
]
],
[
[
50,
24,
971
],
[
971,
64,
1070
]
],
[
[
50,
24,
328
],
[
328,
25... | [
[
[
"Sulfasalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[
"Dicl... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may lead to a major life threatening interaction when taken with Mipomersen
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib ... |
DB00934 | DB01177 | 413 | 77 | [
"DDInter1124",
"DDInter904"
] | Maprotiline | Idarubicin | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
413,
24,
77
]
],
[
[
413,
6,
12523
],
[
12523,
45,
77
]
],
[
[
413,
7,
2507
],
[
2507,
46,
77
]
],
[
[
413,
18,
9205
],
[
9205,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Maprotiline",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Maprotiline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Maprotiline (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is upregulated by Idarubicin (Compound)
Maprotiline (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Idarubicin (Compound)
Maprotiline... |
DB01224 | DB08897 | 623 | 1,429 | [
"DDInter1553",
"DDInter22"
] | Quetiapine | Aclidinium | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
623,
24,
1429
]
],
[
[
623,
63,
352
],
[
352,
24,
1429
]
],
[
[
623,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
623,
6,
4304
],
[
4304,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzola... |
DB00843 | DB08899 | 479 | 129 | [
"DDInter583",
"DDInter649"
] | Donepezil | Enzalutamide | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
479,
24,
129
]
],
[
[
479,
23,
918
],
[
918,
1,
129
]
],
[
[
479,
6,
8374
],
[
8374,
45,
129
]
],
[
[
479,
21,
28703
],
[
28703,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bicalutamide"
],
[
... | Donepezil may cause a minor interaction that can limit clinical effects when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Donepezil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Donepezil (Compound) causes Pruritus (Side Effect) and Pruritu... |
DB00862 | DB01612 | 1,005 | 1,637 | [
"DDInter1918",
"DDInter92"
] | Vardenafil | Amyl Nitrite | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Major | 2 | [
[
[
1005,
25,
1637
]
],
[
[
1005,
24,
714
],
[
714,
24,
1637
]
],
[
[
1005,
63,
1061
],
[
1061,
24,
1637
]
],
[
[
1005,
24,
433
],
[
433,
... | [
[
[
"Vardenafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
[
"Iloprost",... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Trepro... |
DB00694 | DB05812 | 51 | 1,374 | [
"DDInter485",
"DDInter8"
] | Daunorubicin | Abiraterone | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
51,
24,
1374
]
],
[
[
51,
6,
10417
],
[
10417,
45,
1374
]
],
[
[
51,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
51,
24,
466
],
[
466,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Daunorubicin",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compound... | Daunorubicin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Abiraterone (Compound)
Daunorubicin (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Daunorubicin may cause a moderate interaction that could exacerbate diseases w... |
DB00708 | DB00747 | 1,454 | 1,442 | [
"DDInter1718",
"DDInter1647"
] | Sufentanil | Scopolamine | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
1454,
24,
1442
]
],
[
[
1454,
63,
19
],
[
19,
24,
1442
]
],
[
[
1454,
21,
28766
],
[
28766,
60,
1442
]
],
[
[
1454,
1,
411
],
[
411,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Sufentanil (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Scopolamine... |
DB00041 | DB00370 | 1,648 | 1,251 | [
"DDInter38",
"DDInter1230"
] | Aldesleukin | Mirtazapine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Moderate | 1 | [
[
[
1648,
24,
1251
]
],
[
[
1648,
24,
104
],
[
104,
40,
1251
]
],
[
[
1648,
24,
888
],
[
888,
63,
1251
]
],
[
[
1648,
24,
1594
],
[
1594,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Mirtazapine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that ... |
DB00204 | DB06791 | 228 | 1,446 | [
"DDInter580",
"DDInter1021"
] | Dofetilide | Lanreotide | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
228,
24,
1446
]
],
[
[
228,
24,
1017
],
[
1017,
63,
1446
]
],
[
[
228,
62,
1324
],
[
1324,
24,
1446
]
],
[
[
228,
25,
971
],
[
971,
... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Dofetilide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Dofetilide may cause a minor interaction that can limit clinical effects when taken with Troglitazone and Trogli... |
DB00731 | DB09381 | 1,144 | 192 | [
"DDInter1269",
"DDInter678"
] | Nateglinide | Esterified estrogens | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1144,
24,
192
]
],
[
[
1144,
24,
1019
],
[
1019,
63,
192
]
],
[
[
1144,
24,
5
],
[
5,
24,
192
]
],
[
[
1144,
62,
1051
],
[
1051,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Liraglu... |
DB00526 | DB01142 | 1,555 | 1,264 | [
"DDInter1355",
"DDInter593"
] | Oxaliplatin | Doxepin | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1555,
24,
1264
]
],
[
[
1555,
63,
508
],
[
508,
24,
1264
]
],
[
[
1555,
24,
401
],
[
401,
24,
1264
]
],
[
[
1555,
6,
7950
],
[
7950,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prometh... |
DB00465 | DB00631 | 886 | 372 | [
"DDInter1010",
"DDInter405"
] | Ketorolac | Clofarabine | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
886,
24,
372
]
],
[
[
886,
6,
7720
],
[
7720,
46,
372
]
],
[
[
886,
18,
3222
],
[
3222,
46,
372
]
],
[
[
886,
7,
2900
],
[
2900,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Ketorolac",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregulated by {v} (Compound... | Ketorolac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Clofarabine (Compound)
Ketorolac (Compound) downregulates DUSP4 (Gene) and DUSP4 (Gene) is upregulated by Clofarabine (Compound)
Ketorolac (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Clofarabine (Compound)
Ketorolac ... |
DB00731 | DB01267 | 1,144 | 519 | [
"DDInter1269",
"DDInter1381"
] | Nateglinide | Paliperidone | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1144,
24,
519
]
],
[
[
1144,
24,
1664
],
[
1664,
1,
519
]
],
[
[
1144,
6,
7524
],
[
7524,
45,
519
]
],
[
[
1144,
21,
28826
],
[
28826,... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Nateglinide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paliperidone (Compound)
Nateglinide (Compound) causes Jaundice (Side Effect) and J... |
DB09030 | DB12887 | 840 | 1,598 | [
"DDInter1945",
"DDInter1750"
] | Vorapaxar | Tazemetostat | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Major | 2 | [
[
[
840,
25,
1598
]
],
[
[
840,
24,
738
],
[
738,
24,
1598
]
],
[
[
840,
63,
1039
],
[
1039,
24,
1598
]
],
[
[
840,
25,
405
],
[
405,
... | [
[
[
"Vorapaxar",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tazemetostat"
]
],
[
[
"Vorapaxar",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
"Niraparib",... | Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dex... |
DB00444 | DB08868 | 63 | 1,011 | [
"DDInter1765",
"DDInter737"
] | Teniposide | Fingolimod | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
63,
25,
1011
]
],
[
[
63,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
63,
21,
28714
],
[
28714,
60,
1011
]
],
[
[
63,
24,
112
],
[
112,
... | [
[
[
"Teniposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Teniposide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingoli... | Teniposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Teniposide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Fingolimod (Compound)
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Met... |
DB00582 | DB00681 | 1,622 | 1,287 | [
"DDInter1946",
"DDInter85"
] | Voriconazole | Amphotericin B | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Minor | 0 | [
[
[
1622,
23,
1287
]
],
[
[
1622,
21,
29026
],
[
29026,
60,
1287
]
],
[
[
1622,
74,
600
],
[
600,
23,
1287
]
],
[
[
1622,
24,
86
],
[
86,
... | [
[
[
"Voriconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amphotericin B"
]
],
[
[
"Voriconazole",
"{u} (Compound) causes {v} (Side Effect)",
"Bone pain"
],
[
"Bone pain",
"{u} (Side Effect) i... | Voriconazole (Compound) causes Bone pain (Side Effect) and Bone pain (Side Effect) is caused by Amphotericin B (Compound)
Voriconazole (Compound) resembles Fluconazole (Compound) and Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a mino... |
DB00682 | DB01101 | 126 | 60 | [
"DDInter1951",
"DDInter285"
] | Warfarin | Capecitabine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Major | 2 | [
[
[
126,
25,
60
]
],
[
[
126,
6,
6017
],
[
6017,
45,
60
]
],
[
[
126,
25,
872
],
[
872,
62,
60
]
],
[
[
126,
64,
1176
],
[
1176,
23,... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Capecitabine"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Capecitab... | Warfarin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Capecitabine (Compound)
Warfarin may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Capecitabine
Warfarin may lead to a major li... |
DB00039 | DB01168 | 1,253 | 1,053 | [
"DDInter1380",
"DDInter1526"
] | Palifermin | Procarbazine | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1253,
24,
1053
]
],
[
[
1253,
24,
1648
],
[
1648,
24,
1053
]
],
[
[
1253,
24,
738
],
[
738,
63,
1053
]
],
[
[
1253,
24,
1064
],
[
1064... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Nir... |
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