drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00342 | DB00344 | 1,181 | 1,302 | [
"DDInter1770",
"DDInter1543"
] | Terfenadine | Protriptyline | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Moderate | 1 | [
[
[
1181,
24,
1302
]
],
[
[
1181,
24,
413
],
[
413,
1,
1302
]
],
[
[
1181,
63,
847
],
[
847,
1,
1302
]
],
[
[
1181,
23,
112
],
[
112,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
],
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Protriptyline (Compound)
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Protriptyline... |
DB00242 | DB06372 | 1,064 | 259 | [
"DDInter392",
"DDInter1594"
] | Cladribine | Rilonacept | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Major | 2 | [
[
[
1064,
25,
259
]
],
[
[
1064,
63,
1461
],
[
1461,
23,
259
]
],
[
[
1064,
25,
0
],
[
0,
24,
259
]
],
[
[
1064,
25,
1619
],
[
1619,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Cladribine may lead to a major life threatening interaction when taken with Dactinomycin and Dactinomycin may cause ... |
DB01030 | DB08871 | 869 | 36 | [
"DDInter1835",
"DDInter666"
] | Topotecan | Eribulin | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
869,
24,
36
]
],
[
[
869,
24,
221
],
[
221,
63,
36
]
],
[
[
869,
63,
563
],
[
563,
24,
36
]
],
[
[
869,
24,
1488
],
[
1488,
24,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (form... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Topotecan may cause a moderate ... |
DB00804 | DB00844 | 1,507 | 314 | [
"DDInter543",
"DDInter1257"
] | Dicyclomine | Nalbuphine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Moderate | 1 | [
[
[
1507,
24,
314
]
],
[
[
1507,
63,
828
],
[
828,
40,
314
]
],
[
[
1507,
63,
421
],
[
421,
1,
314
]
],
[
[
1507,
63,
475
],
[
475,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Nalbuphine (Comp... |
DB00877 | DB09291 | 629 | 741 | [
"DDInter1678",
"DDInter1615"
] | Sirolimus | Rolapitant | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
629,
24,
741
]
],
[
[
629,
24,
211
],
[
211,
23,
741
]
],
[
[
629,
24,
159
],
[
159,
63,
741
]
],
[
[
629,
24,
1671
],
[
1671,
2... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Rolapitant
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB06414 | DB09074 | 655 | 1,362 | [
"DDInter703",
"DDInter1327"
] | Etravirine | Olaparib | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
655,
25,
1362
]
],
[
[
655,
63,
896
],
[
896,
24,
1362
]
],
[
[
655,
24,
1478
],
[
1478,
24,
1362
]
],
[
[
655,
62,
168
],
[
168,
... | [
[
[
"Etravirine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"Etoposide",
... | Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor m... |
DB00771 | DB00999 | 262 | 504 | [
"DDInter397",
"DDInter883"
] | Clidinium | Hydrochlorothiazide | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Minor | 0 | [
[
[
262,
23,
504
]
],
[
[
262,
23,
178
],
[
178,
1,
504
]
],
[
[
262,
62,
323
],
[
323,
40,
504
]
],
[
[
262,
23,
359
],
[
359,
40,
... | [
[
[
"Clidinium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Clidinium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Polythiazide"
],
... | Clidinium may cause a minor interaction that can limit clinical effects when taken with Polythiazide and Polythiazide (Compound) resembles Hydrochlorothiazide (Compound)
Clidinium may cause a minor interaction that can limit clinical effects when taken with Bendroflumethiazide and Bendroflumethiazide (Compound) resembl... |
DB04845 | DB10583 | 309 | 949 | [
"DDInter1001",
"DDInter415"
] | Ixabepilone | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
309,
24,
949
]
],
[
[
309,
63,
589
],
[
589,
24,
949
]
],
[
[
309,
64,
1377
],
[
1377,
24,
949
]
],
[
[
309,
24,
980
],
[
980,
2... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Ixabepilone may lead to a major life threatening interaction wh... |
DB00945 | DB11921 | 1,479 | 1,019 | [
"DDInter20",
"DDInter492"
] | Acetylsalicylic acid | Deflazacort | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1479,
24,
1019
]
],
[
[
1479,
63,
1461
],
[
1461,
23,
1019
]
],
[
[
1479,
62,
443
],
[
443,
24,
1019
]
],
[
[
1479,
24,
959
],
[
959,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitami... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Spiron... |
DB01285 | DB09020 | 708 | 28 | [
"DDInter445",
"DDInter212"
] | Corticotropin | Bisacodyl | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
708,
24,
28
]
],
[
[
708,
63,
954
],
[
954,
24,
28
]
],
[
[
708,
64,
932
],
[
932,
24,
28
]
],
[
[
708,
24,
286
],
[
286,
63,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
],
... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Corticotropin may lead to a major life threatening interaction when taken with Mifepristone and Mifepristone may... |
DB00063 | DB00554 | 366 | 1,027 | [
"DDInter659",
"DDInter1478"
] | Eptifibatide | Piroxicam | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Moderate | 1 | [
[
[
366,
24,
1027
]
],
[
[
366,
24,
1171
],
[
1171,
1,
1027
]
],
[
[
366,
24,
222
],
[
222,
63,
1027
]
],
[
[
366,
64,
1578
],
[
1578,
... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
]
],
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
],
[
... | Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam (Compound) resembles Piroxicam (Compound)
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that co... |
DB01229 | DB15093 | 973 | 1,654 | [
"DDInter1377",
"DDInter1698"
] | Paclitaxel | Somapacitan | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
973,
24,
1654
]
],
[
[
973,
63,
168
],
[
168,
23,
1654
]
],
[
[
973,
63,
10
],
[
10,
24,
1654
]
],
[
[
973,
24,
351
],
[
351,
24... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone ma... |
DB00286 | DB14568 | 380 | 982 | [
"DDInter439",
"DDInter1000"
] | Conjugated estrogens | Ivosidenib | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
380,
24,
982
]
],
[
[
380,
24,
1101
],
[
1101,
23,
982
]
],
[
[
380,
25,
770
],
[
770,
24,
982
]
],
[
[
380,
24,
1478
],
[
1478,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarot... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Conjugated estrogens may lead to a major life threatening interaction when taken with Thalidomide and Th... |
DB00531 | DB00701 | 450 | 1,091 | [
"DDInter456",
"DDInter90"
] | Cyclophosphamide | Amprenavir | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Amprenavir is a protease inhibitor used to treat HIV infection. | Moderate | 1 | [
[
[
450,
24,
1091
]
],
[
[
450,
24,
34
],
[
34,
1,
1091
]
],
[
[
450,
6,
4973
],
[
4973,
45,
1091
]
],
[
[
450,
21,
28996
],
[
28996,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir (Compound) resembles Amprenavir (Compound)
Cyclophosphamide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amprenavir (Compound)
Cyclophosphamide (Compound) causes Musculoskeletal... |
DB00495 | DB01181 | 139 | 1,532 | [
"DDInter1961",
"DDInter906"
] | Zidovudine | Ifosfamide | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
139,
24,
1532
]
],
[
[
139,
6,
8717
],
[
8717,
45,
1532
]
],
[
[
139,
21,
29209
],
[
29209,
60,
1532
]
],
[
[
139,
63,
1648
],
[
1648,... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Zidovudine",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
"CYP2A6",
"{u} (Gene) is bound by {v} (Compound)",... | Zidovudine (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Ifosfamide (Compound)
Zidovudine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldes... |
DB09036 | DB11581 | 812 | 1,456 | [
"DDInter1668",
"DDInter1926"
] | Siltuximab | Venetoclax | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
812,
24,
1456
]
],
[
[
812,
63,
259
],
[
259,
24,
1456
]
],
[
[
812,
24,
1129
],
[
1129,
63,
1456
]
],
[
[
812,
24,
221
],
[
221,
... | [
[
[
"Siltuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Siltuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Siltuximab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Siltuximab may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e se... |
DB00549 | DB12825 | 522 | 1,375 | [
"DDInter1955",
"DDInter1032"
] | Zafirlukast | Lefamulin | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
522,
24,
1375
]
],
[
[
522,
24,
112
],
[
112,
23,
1375
]
],
[
[
522,
24,
159
],
[
159,
63,
1375
]
],
[
[
522,
24,
309
],
[
309,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib an... |
DB00005 | DB08880 | 1,057 | 1,510 | [
"DDInter687",
"DDInter1771"
] | Etanercept | Teriflunomide | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1057,
25,
1510
]
],
[
[
1057,
23,
1461
],
[
1461,
23,
1510
]
],
[
[
1057,
23,
1193
],
[
1193,
62,
1510
]
],
[
[
1057,
24,
608
],
[
608... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gl... |
DB00501 | DB00841 | 752 | 532 | [
"DDInter380",
"DDInter577"
] | Cimetidine | Dobutamine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Moderate | 1 | [
[
[
752,
24,
532
]
],
[
[
752,
24,
1523
],
[
1523,
40,
532
]
],
[
[
752,
21,
28784
],
[
28784,
60,
532
]
],
[
[
752,
24,
473
],
[
473,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Dobutamine (Compound)
Cimetidine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Dobutamine (Compound)
Cimetidine may cause a moderate ... |
DB00176 | DB01088 | 529 | 714 | [
"DDInter770",
"DDInter908"
] | Fluvoxamine | Iloprost | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
529,
24,
714
]
],
[
[
529,
24,
1479
],
[
1479,
24,
714
]
],
[
[
529,
63,
1648
],
[
1648,
24,
714
]
],
[
[
529,
24,
1564
],
[
1564,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with A... |
DB01170 | DB06691 | 1,150 | 849 | [
"DDInter846",
"DDInter1155"
] | Guanethidine | Mepyramine | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1150,
24,
849
]
],
[
[
1150,
63,
1648
],
[
1648,
24,
849
]
],
[
[
1150,
24,
407
],
[
407,
63,
849
]
],
[
[
1150,
64,
1214
],
[
1214,
... | [
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium... |
DB08918 | DB09241 | 41 | 1,629 | [
"DDInter1059",
"DDInter1186"
] | Levomilnacipran | Methylene blue | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
41,
25,
1629
]
],
[
[
41,
63,
1148
],
[
1148,
24,
1629
]
],
[
[
41,
24,
659
],
[
659,
24,
1629
]
],
[
[
41,
64,
73
],
[
73,
25,
... | [
[
[
"Levomilnacipran",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Vil... |
DB04951 | DB14730 | 187 | 1,412 | [
"DDInter1477",
"DDInter264"
] | Pirfenidone | Calaspargase pegol | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
187,
24,
1412
]
],
[
[
187,
25,
868
],
[
868,
24,
1412
]
],
[
[
187,
24,
850
],
[
850,
24,
1412
]
],
[
[
187,
63,
482
],
[
482,
... | [
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Pirfenidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
... | Pirfenidone may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and ... |
DB00472 | DB01168 | 758 | 1,053 | [
"DDInter758",
"DDInter1526"
] | Fluoxetine | Procarbazine | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
758,
25,
1053
]
],
[
[
758,
24,
848
],
[
848,
40,
1053
]
],
[
[
758,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
758,
24,
126
],
[
126,
... | [
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ibuprofen... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Fluoxetine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Fluoxetine may cause a moderate interaction ... |
DB01023 | DB06691 | 409 | 849 | [
"DDInter716",
"DDInter1155"
] | Felodipine | Mepyramine | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
409,
24,
849
]
],
[
[
409,
6,
12523
],
[
12523,
45,
849
]
],
[
[
409,
24,
770
],
[
770,
24,
849
]
],
[
[
409,
63,
1648
],
[
1648,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Felodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Felodipine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Felodipine may c... |
DB00434 | DB00777 | 13 | 146 | [
"DDInter459",
"DDInter1537"
] | Cyproheptadine | Propiomazine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Moderate | 1 | [
[
[
13,
24,
146
]
],
[
[
13,
63,
508
],
[
508,
1,
146
]
],
[
[
13,
24,
401
],
[
401,
63,
146
]
],
[
[
13,
24,
1178
],
[
1178,
1,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Propiomazine (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interactio... |
DB00197 | DB08870 | 1,324 | 850 | [
"DDInter1881",
"DDInter228"
] | Troglitazone | Brentuximab vedotin | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1324,
24,
850
]
],
[
[
1324,
24,
267
],
[
267,
24,
850
]
],
[
[
1324,
24,
1033
],
[
1033,
63,
850
]
],
[
[
1324,
63,
305
],
[
305,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisi... |
DB00986 | DB01619 | 1,192 | 830 | [
"DDInter834",
"DDInter1441"
] | Glycopyrronium | Phenindamine | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1192,
24,
830
]
],
[
[
1192,
24,
537
],
[
537,
40,
830
]
],
[
[
1192,
63,
1219
],
[
1219,
40,
830
]
],
[
[
1192,
63,
357
],
[
357,
... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Co... |
DB00218 | DB01064 | 1,176 | 1,148 | [
"DDInter1247",
"DDInter987"
] | Moxifloxacin | Isoprenaline | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Major | 2 | [
[
[
1176,
25,
1148
]
],
[
[
1176,
24,
480
],
[
480,
24,
1148
]
],
[
[
1176,
21,
29316
],
[
29316,
60,
1148
]
],
[
[
1176,
25,
251
],
[
251... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
]
],
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Form... | Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Moxifloxacin (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Isoprenaline (... |
DB00290 | DB12674 | 329 | 975 | [
"DDInter219",
"DDInter1105"
] | Bleomycin | Lurbinectedin | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
329,
24,
975
]
],
[
[
329,
24,
1488
],
[
1488,
24,
975
]
],
[
[
329,
63,
1257
],
[
1257,
24,
975
]
],
[
[
329,
25,
850
],
[
850,
... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim and ... |
DB00675 | DB01064 | 888 | 1,148 | [
"DDInter1744",
"DDInter987"
] | Tamoxifen | Isoprenaline | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
888,
24,
1148
]
],
[
[
888,
24,
480
],
[
480,
24,
1148
]
],
[
[
888,
6,
9842
],
[
9842,
45,
1148
]
],
[
[
888,
18,
6929
],
[
6929,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Tamoxifen (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Isoprenaline (Compound)
Tamoxifen (Compo... |
DB00798 | DB01332 | 1,132 | 731 | [
"DDInter815",
"DDInter332"
] | Gentamicin | Ceftizoxime | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to b... | Moderate | 1 | [
[
[
1132,
24,
731
]
],
[
[
1132,
24,
1453
],
[
1453,
1,
731
]
],
[
[
1132,
24,
1403
],
[
1403,
40,
731
]
],
[
[
1132,
63,
1087
],
[
1087,
... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftizoxime"
]
],
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftriaxone"
],
[
... | Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Ceftriaxone and Ceftriaxone (Compound) resembles Ceftizoxime (Compound)
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Cefepime and Cefepime (Compound) resembles Ceftizoxime (Compound)
... |
DB00762 | DB01254 | 613 | 1,213 | [
"DDInter973",
"DDInter484"
] | Irinotecan | Dasatinib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
613,
24,
1213
]
],
[
[
613,
5,
11555
],
[
11555,
44,
1213
]
],
[
[
613,
6,
17404
],
[
17404,
45,
1213
]
],
[
[
613,
7,
2653
],
[
2653,... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Irinotecan",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Irinotecan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dasatinib (Compound)
Irinotecan (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Irinotecan (Compound) upregulates LIMK2 (Gene) and LIMK2 (Gene) is bound by Dasatinib (Compound)
Irinot... |
DB01166 | DB09082 | 477 | 659 | [
"DDInter379",
"DDInter1934"
] | Cilostazol | Vilanterol | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
477,
24,
659
]
],
[
[
477,
63,
1570
],
[
1570,
24,
659
]
],
[
[
477,
24,
927
],
[
927,
63,
659
]
],
[
[
477,
25,
1155
],
[
1155,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and E... |
DB00554 | DB01191 | 1,027 | 1,039 | [
"DDInter1478",
"DDInter518"
] | Piroxicam | Dexfenfluramine | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
1027,
24,
1039
]
],
[
[
1027,
6,
6017
],
[
6017,
45,
1039
]
],
[
[
1027,
24,
1046
],
[
1046,
63,
1039
]
],
[
[
1027,
25,
500
],
[
500,... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Piroxicam",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound... | Piroxicam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dexfenfluramine (Compound)
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Piroxi... |
DB01234 | DB10276 | 1,220 | 1,624 | [
"DDInter513",
"DDInter1623"
] | Dexamethasone | Rotavirus vaccine | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1220,
25,
1624
]
],
[
[
1220,
1,
617
],
[
617,
24,
1624
]
],
[
[
1220,
63,
1648
],
[
1648,
25,
1624
]
],
[
[
1220,
64,
770
],
[
770,
... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Dexamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Budesonide"
],
[
"Budesonide",
"{u} may cause a moderate ... | Dexamethasone (Compound) resembles Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may lead to a major life thr... |
DB00691 | DB01276 | 1,058 | 123 | [
"DDInter1237",
"DDInter706"
] | Moexipril | Exenatide | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1058,
24,
123
]
],
[
[
1058,
24,
708
],
[
708,
63,
123
]
],
[
[
1058,
63,
1573
],
[
1573,
24,
123
]
],
[
[
1058,
24,
820
],
[
820,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Pre... |
DB00759 | DB01028 | 1,620 | 1,332 | [
"DDInter1783",
"DDInter1179"
] | Tetracycline | Methoxyflurane | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Major | 2 | [
[
[
1620,
25,
1332
]
],
[
[
1620,
6,
8374
],
[
8374,
45,
1332
]
],
[
[
1620,
63,
663
],
[
663,
24,
1332
]
],
[
[
1620,
1,
964
],
[
964,
... | [
[
[
"Tetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methoxyflurane"
]
],
[
[
"Tetracycline",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tetracycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Methoxyflurane (Compound)
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Te... |
DB00413 | DB01233 | 1,346 | 1,311 | [
"DDInter1505",
"DDInter1197"
] | Pramipexole | Metoclopramide | Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson's Disease is one of the mos... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1346,
24,
1311
]
],
[
[
1346,
6,
5289
],
[
5289,
45,
1311
]
],
[
[
1346,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
1346,
24,
649
],
[
64... | [
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Pramipexole",
"{u} (Compound) binds {v} (Gene)",
"DRD3"
],
[
"DRD3",
"{u} (Gene) is bound by {v} (Compound)... | Pramipexole (Compound) binds DRD3 (Gene) and DRD3 (Gene) is bound by Metoclopramide (Compound)
Pramipexole (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol... |
DB00331 | DB01021 | 1,645 | 674 | [
"DDInter1164",
"DDInter1861"
] | Metformin | Trichlormethiazide | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
1645,
24,
674
]
],
[
[
1645,
24,
1014
],
[
1014,
40,
674
]
],
[
[
1645,
24,
178
],
[
178,
1,
674
]
],
[
[
1645,
25,
1326
],
[
1326,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Trichlor... |
DB00270 | DB00653 | 1,428 | 544 | [
"DDInter993",
"DDInter1120"
] | Isradipine | Magnesium sulfate | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Moderate | 1 | [
[
[
1428,
24,
544
]
],
[
[
1428,
6,
2044
],
[
2044,
45,
544
]
],
[
[
1428,
21,
28717
],
[
28717,
60,
544
]
],
[
[
1428,
40,
854
],
[
854,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfate"
]
],
[
[
"Isradipine",
"{u} (Compound) binds {v} (Gene)",
"CACNB2"
],
[
"CACNB2",
"{u} (Gene) is bound by {v} (Comp... | Isradipine (Compound) binds CACNB2 (Gene) and CACNB2 (Gene) is bound by Magnesium sulfate (Compound)
Isradipine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Magnesium sulfate (Compound)
Isradipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interact... |
DB00990 | DB12010 | 1,547 | 214 | [
"DDInter705",
"DDInter785"
] | Exemestane | Fostamatinib | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1547,
24,
214
]
],
[
[
1547,
63,
690
],
[
690,
24,
214
]
],
[
[
1547,
1,
1573
],
[
1573,
24,
214
]
],
[
[
1547,
24,
179
],
[
179,
... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Exemestane (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that could... |
DB00006 | DB00261 | 942 | 702 | [
"DDInter217",
"DDInter93"
] | Bivalirudin | Anagrelide | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Major | 2 | [
[
[
942,
25,
702
]
],
[
[
942,
23,
539
],
[
539,
62,
702
]
],
[
[
942,
24,
935
],
[
935,
63,
702
]
],
[
[
942,
24,
529
],
[
529,
24,... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anagrelide"
]
],
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Anagrelide
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen m... |
DB00284 | DB05528 | 1,647 | 1,070 | [
"DDInter11",
"DDInter1228"
] | Acarbose | Mipomersen | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
1647,
25,
1070
]
],
[
[
1647,
24,
384
],
[
384,
64,
1070
]
],
[
[
1647,
63,
168
],
[
168,
25,
1070
]
],
[
[
1647,
24,
1142
],
[
1142,
... | [
[
[
"Acarbose",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
"Idelalisib",
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may lead to a major life threatening interaction when taken with Mipomersen
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may lead to a ... |
DB00373 | DB09112 | 461 | 1,455 | [
"DDInter1809",
"DDInter1306"
] | Timolol | Nitrous acid | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
461,
24,
1455
]
],
[
[
461,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
461,
1,
729
],
[
729,
24,
1455
]
],
[
[
461,
24,
433
],
[
433,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Timolol (Compound) resembles Penbutolol (Compound) and Penbutolol may cause a moderate interaction that cou... |
DB00445 | DB00549 | 322 | 522 | [
"DDInter655",
"DDInter1955"
] | Epirubicin | Zafirlukast | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Moderate | 1 | [
[
[
322,
24,
522
]
],
[
[
322,
24,
165
],
[
165,
40,
522
]
],
[
[
322,
21,
28935
],
[
28935,
60,
522
]
],
[
[
322,
24,
479
],
[
479,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvaptan (Compound) resembles Zafirlukast (Compound)
Epirubicin (Compound) causes Hyperbilirubinaemia (Side Effect) and Hyperbilirubinaemia (Side Effect) is caused by Zafirlukast (Compound)
Epirubicin may cause a m... |
DB00023 | DB00968 | 305 | 1,551 | [
"DDInter127",
"DDInter1185"
] | Asparaginase Escherichia coli | Methyldopa | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Moderate | 1 | [
[
[
305,
24,
1551
]
],
[
[
305,
24,
959
],
[
959,
62,
1551
]
],
[
[
305,
24,
590
],
[
590,
23,
1551
]
],
[
[
305,
24,
1648
],
[
1648,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyldopa"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a minor interaction that can limit clinical effects when taken with Methyldopa
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases whe... |
DB00851 | DB05273 | 611 | 507 | [
"DDInter463",
"DDInter1638"
] | Dacarbazine | Samarium (153Sm) lexidronam | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
611,
25,
507
]
],
[
[
611,
24,
248
],
[
248,
24,
507
]
],
[
[
611,
24,
270
],
[
270,
63,
507
]
],
[
[
611,
63,
970
],
[
970,
25,... | [
[
[
"Dacarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken... |
DB06077 | DB08899 | 879 | 129 | [
"DDInter1102",
"DDInter649"
] | Lumateperone | Enzalutamide | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
879,
25,
129
]
],
[
[
879,
63,
918
],
[
918,
1,
129
]
],
[
[
879,
63,
79
],
[
79,
24,
129
]
],
[
[
879,
25,
1320
],
[
1320,
63,
... | [
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
"Bi... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction th... |
DB00723 | DB11827 | 1,240 | 433 | [
"DDInter1176",
"DDInter669"
] | Methoxamine | Ertugliflozin | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1240,
24,
433
]
],
[
[
1240,
24,
959
],
[
959,
24,
433
]
],
[
[
1240,
63,
1466
],
[
1466,
24,
433
]
],
[
[
1240,
24,
959
],
[
959,
... | [
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Phenylpropanolamin... |
DB00078 | DB08918 | 1,172 | 41 | [
"DDInter898",
"DDInter1059"
] | Ibritumomab tiuxetan | Levomilnacipran | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
1172,
24,
41
]
],
[
[
1172,
24,
901
],
[
901,
40,
41
]
],
[
[
1172,
25,
498
],
[
498,
63,
41
]
],
[
[
1172,
25,
330
],
[
330,
24... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mi... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a moderate interaction th... |
DB01263 | DB11691 | 859 | 1,499 | [
"DDInter1494",
"DDInter1258"
] | Posaconazole | Naldemedine | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
859,
24,
1499
]
],
[
[
859,
63,
723
],
[
723,
24,
1499
]
],
[
[
859,
25,
1670
],
[
1670,
24,
1499
]
],
[
[
859,
25,
1406
],
[
1406,
... | [
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Posaconazole may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may c... |
DB00341 | DB00599 | 1,242 | 682 | [
"DDInter343",
"DDInter1795"
] | Cetirizine | Thiopental | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does no... | Moderate | 1 | [
[
[
1242,
24,
682
]
],
[
[
1242,
63,
1023
],
[
1023,
1,
682
]
],
[
[
1242,
24,
536
],
[
536,
1,
682
]
],
[
[
1242,
24,
401
],
[
401,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiopental"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],
[... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Thiopental (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Thiopental (... |
DB00242 | DB11581 | 1,064 | 1,456 | [
"DDInter392",
"DDInter1926"
] | Cladribine | Venetoclax | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
1064,
25,
1456
]
],
[
[
1064,
25,
259
],
[
259,
24,
1456
]
],
[
[
1064,
24,
1129
],
[
1129,
63,
1456
]
],
[
[
1064,
25,
1476
],
[
1476... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
"Rilonacept",
"{u} m... | Cladribine may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain... |
DB00444 | DB12332 | 63 | 1,619 | [
"DDInter1765",
"DDInter1626"
] | Teniposide | Rucaparib | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
63,
24,
1619
]
],
[
[
63,
23,
307
],
[
307,
23,
1619
]
],
[
[
63,
24,
112
],
[
112,
23,
1619
]
],
[
[
63,
24,
259
],
[
259,
24,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Teniposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Teniposide may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidaz... |
DB08870 | DB09054 | 850 | 384 | [
"DDInter228",
"DDInter905"
] | Brentuximab vedotin | Idelalisib | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
850,
24,
384
]
],
[
[
850,
24,
1627
],
[
1627,
62,
384
]
],
[
[
850,
63,
72
],
[
72,
24,
384
]
],
[
[
850,
24,
1618
],
[
1618,
2... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidi... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Elt... |
DB00115 | DB00448 | 227 | 1,215 | [
"DDInter451",
"DDInter1022"
] | Cyanocobalamin | Lansoprazole | Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria, and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-, met... | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Minor | 0 | [
[
[
227,
23,
1215
]
],
[
[
227,
23,
379
],
[
379,
1,
1215
]
],
[
[
227,
23,
379
],
[
379,
40,
660
],
[
660,
1,
1215
]
],
[
[
227,
23... | [
[
[
"Cyanocobalamin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lansoprazole"
]
],
[
[
"Cyanocobalamin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rabeprazole"
],
... | Cyanocobalamin may cause a minor interaction that can limit clinical effects when taken with Rabeprazole and Rabeprazole (Compound) resembles Lansoprazole (Compound)
Cyanocobalamin may cause a minor interaction that can limit clinical effects when taken with Rabeprazole and Rabeprazole (Compound) resembles Esomeprazole... |
DB00163 | DB04932 | 1,461 | 1,564 | [
"DDInter1943",
"DDInter491"
] | Vitamin E | Defibrotide | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
1461,
24,
1564
]
],
[
[
1461,
24,
714
],
[
714,
24,
1564
]
],
[
[
1461,
24,
1347
],
[
1347,
25,
1564
]
],
[
[
1461,
24,
802
],
[
802,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogre... |
DB00015 | DB01254 | 582 | 1,213 | [
"DDInter1585",
"DDInter484"
] | Reteplase | Dasatinib | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
582,
25,
1213
]
],
[
[
582,
23,
539
],
[
539,
62,
1213
]
],
[
[
582,
24,
738
],
[
738,
63,
1213
]
],
[
[
582,
24,
383
],
[
383,
... | [
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dasatinib
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may caus... |
DB09054 | DB12457 | 384 | 1,180 | [
"DDInter905",
"DDInter1598"
] | Idelalisib | Rimegepant | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Moderate | 1 | [
[
[
384,
24,
1180
]
],
[
[
384,
24,
1619
],
[
1619,
24,
1180
]
],
[
[
384,
63,
1419
],
[
1419,
24,
1180
]
],
[
[
384,
24,
1501
],
[
1501,
... | [
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimegepant"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib m... |
DB06603 | DB09118 | 39 | 1,580 | [
"DDInter1387",
"DDInter1711"
] | Panobinostat | Stiripentol | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
39,
24,
1580
]
],
[
[
39,
25,
1409
],
[
1409,
24,
1580
]
],
[
[
39,
25,
283
],
[
283,
63,
1580
]
],
[
[
39,
64,
1018
],
[
1018,
... | [
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
],
[
"Apixaba... | Panobinostat may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Panobinostat may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate int... |
DB01069 | DB09045 | 401 | 52 | [
"DDInter1533",
"DDInter607"
] | Promethazine | Dulaglutide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
401,
24,
52
]
],
[
[
401,
24,
170
],
[
170,
23,
52
]
],
[
[
401,
24,
609
],
[
609,
24,
52
]
],
[
[
401,
63,
73
],
[
73,
24,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin a... |
DB01619 | DB09293 | 830 | 116 | [
"DDInter1441",
"DDInter954"
] | Phenindamine | Iodide I-131 | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
830,
24,
116
]
],
[
[
830,
63,
701
],
[
701,
24,
116
]
],
[
[
830,
24,
516
],
[
516,
24,
116
]
],
[
[
830,
40,
104
],
[
104,
24,... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine ... |
DB01083 | DB01124 | 1,142 | 1,411 | [
"DDInter1348",
"DDInter1828"
] | Orlistat | Tolbutamide | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1142,
24,
1411
]
],
[
[
1142,
63,
959
],
[
959,
40,
1411
]
],
[
[
1142,
5,
11640
],
[
11640,
44,
1411
]
],
[
[
1142,
21,
29222
],
[
29... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Orlistat (Compound) treats type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Tolbutamide (Compound)
Orlistat (Compound) cause... |
DB00238 | DB00982 | 188 | 1,517 | [
"DDInter1285",
"DDInter991"
] | Nevirapine | Isotretinoin | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Moderate | 1 | [
[
[
188,
24,
1517
]
],
[
[
188,
21,
28784
],
[
28784,
60,
1517
]
],
[
[
188,
24,
868
],
[
868,
63,
1517
]
],
[
[
188,
24,
663
],
[
663,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
]
],
[
[
"Nevirapine",
"{u} (Compound) causes {v} (Side Effect)",
"Thrombocytopenia"
],
[
"Thrombocytopenia",
"{u} (Side... | Nevirapine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Isotretinoin (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when ... |
DB00586 | DB11817 | 1,512 | 1,259 | [
"DDInter537",
"DDInter165"
] | Diclofenac | Baricitinib | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
1512,
24,
1259
]
],
[
[
1512,
24,
1274
],
[
1274,
24,
1259
]
],
[
[
1512,
63,
598
],
[
598,
24,
1259
]
],
[
[
1512,
64,
886
],
[
886,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and N... |
DB00757 | DB05812 | 1,166 | 1,374 | [
"DDInter581",
"DDInter8"
] | Dolasetron | Abiraterone | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Major | 2 | [
[
[
1166,
25,
1374
]
],
[
[
1166,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
1166,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
1166,
23,
112
],
[
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
]
],
[
[
"Dolasetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Abirat... | Dolasetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Dolasetron (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Dolasetron may cause a minor interaction that can limit clinical effects when ta... |
DB00307 | DB06616 | 1,101 | 594 | [
"DDInter202",
"DDInter224"
] | Bexarotene | Bosutinib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1101,
24,
594
]
],
[
[
1101,
24,
883
],
[
883,
1,
594
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1101,
21,
29231
],
[
29231,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Bexarotene (Compound) causes Cardiac disorder (Side Effect) and Cardia... |
DB00675 | DB11799 | 888 | 627 | [
"DDInter1744",
"DDInter205"
] | Tamoxifen | Bictegravir | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Moderate | 1 | [
[
[
888,
24,
627
]
],
[
[
888,
24,
1362
],
[
1362,
24,
627
]
],
[
[
888,
25,
478
],
[
478,
24,
627
]
],
[
[
888,
63,
600
],
[
600,
2... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Tamoxifen may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moder... |
DB09122 | DB11767 | 1,613 | 1,583 | [
"DDInter1409",
"DDInter1643"
] | Peginterferon beta-1a | Sarilumab | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
1613,
24,
1583
]
],
[
[
1613,
63,
267
],
[
267,
24,
1583
]
],
[
[
1613,
24,
287
],
[
287,
63,
1583
]
],
[
[
1613,
64,
139
],
[
139,
... | [
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltre... | Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB08860 | DB08901 | 788 | 1,468 | [
"DDInter1479",
"DDInter1492"
] | Pitavastatin | Ponatinib | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
788,
24,
1468
]
],
[
[
788,
6,
3486
],
[
3486,
45,
1468
]
],
[
[
788,
7,
7478
],
[
7478,
46,
1468
]
],
[
[
788,
18,
5235
],
[
5235,
... | [
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Pitavastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Pitavastatin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ponatinib (Compound)
Pitavastatin (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Ponatinib (Compound)
Pitavastatin (Compound) downregulates AARS (Gene) and AARS (Gene) is upregulated by Ponatinib (Compound)
Pitavasta... |
DB00564 | DB08904 | 1,236 | 375 | [
"DDInter293",
"DDInter342"
] | Carbamazepine | Certolizumab pegol | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
1236,
24,
375
]
],
[
[
1236,
25,
1593
],
[
1593,
24,
375
]
],
[
[
1236,
24,
303
],
[
303,
24,
375
]
],
[
[
1236,
62,
608
],
[
608,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
... | Carbamazepine may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone ac... |
DB00331 | DB01155 | 1,645 | 872 | [
"DDInter1164",
"DDInter813"
] | Metformin | Gemifloxacin | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
1645,
24,
872
]
],
[
[
1645,
24,
739
],
[
739,
1,
872
]
],
[
[
1645,
24,
945
],
[
945,
40,
872
]
],
[
[
1645,
63,
1176
],
[
1176,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Gemifloxacin (... |
DB08865 | DB11978 | 1,593 | 124 | [
"DDInter448",
"DDInter822"
] | Crizotinib | Glasdegib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1593,
25,
124
]
],
[
[
1593,
25,
1135
],
[
1135,
23,
124
]
],
[
[
1593,
62,
1247
],
[
1247,
23,
124
]
],
[
[
1593,
63,
112
],
[
112,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Crizotinib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Crizotinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may c... |
DB00986 | DB01224 | 1,192 | 623 | [
"DDInter834",
"DDInter1553"
] | Glycopyrronium | Quetiapine | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1192,
24,
623
]
],
[
[
1192,
63,
695
],
[
695,
1,
623
]
],
[
[
1192,
6,
7992
],
[
7992,
45,
623
]
],
[
[
1192,
21,
29039
],
[
29039,
... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Glycopyrronium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Quetiapine (Compound)
Glycopyrronium (Compound) causes Cystitis noninfective (Side E... |
DB01592 | DB09146 | 1,596 | 489 | [
"DDInter975",
"DDInter978"
] | Iron | Iron sucrose | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
1596,
24,
489
]
],
[
[
1596,
24,
943
],
[
943,
63,
489
]
],
[
[
1596,
24,
320
],
[
320,
24,
489
]
],
[
[
1596,
63,
1152
],
[
1152,
... | [
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
],
[
"Sare... | Iron may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline and Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Iron may cause a moderate interaction that could exacerbate diseases when taken with Thyroid, porcine and Thyroid,... |
DB08882 | DB11901 | 1,281 | 913 | [
"DDInter1070",
"DDInter107"
] | Linagliptin | Apalutamide | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1281,
24,
913
]
],
[
[
1281,
24,
1060
],
[
1060,
62,
913
]
],
[
[
1281,
63,
303
],
[
303,
24,
913
]
],
[
[
1281,
24,
255
],
[
255,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enfortumab vedotin may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Medr... |
DB00697 | DB00748 | 876 | 662 | [
"DDInter1821",
"DDInter297"
] | Tizanidine | Carbinoxamine | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
876,
24,
662
]
],
[
[
876,
63,
1594
],
[
1594,
24,
662
]
],
[
[
876,
7,
2384
],
[
2384,
46,
662
]
],
[
[
876,
21,
28921
],
[
28921,
... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Tizanidine (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Carbinoxamine (Compound)
Tiza... |
DB09098 | DB09381 | 98 | 192 | [
"DDInter1700",
"DDInter678"
] | Somatrem | Esterified estrogens | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
98,
24,
192
]
],
[
[
98,
24,
1019
],
[
1019,
63,
192
]
],
[
[
98,
63,
5
],
[
5,
24,
192
]
],
[
[
98,
64,
1101
],
[
1101,
24,
... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
],
... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide a... |
DB10343 | DB11817 | 962 | 1,259 | [
"DDInter160",
"DDInter165"
] | Bacillus calmette-guerin substrain tice live antigen | Baricitinib | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
962,
25,
1259
]
],
[
[
962,
64,
384
],
[
384,
25,
1259
]
],
[
[
962,
25,
1619
],
[
1619,
64,
1259
]
],
[
[
962,
25,
351
],
[
351,
... | [
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction w... | Bacillus calmette-guerin substrain tice live antigen may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may lead to a major life threatening interaction when taken with Baricitinib
Bacillus calmette-guerin substrain tice live antigen may lead to a major life threatening interacti... |
DB00283 | DB00387 | 701 | 1,386 | [
"DDInter395",
"DDInter1528"
] | Clemastine | Procyclidine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Moderate | 1 | [
[
[
701,
24,
1386
]
],
[
[
701,
1,
11268
],
[
11268,
1,
1386
]
],
[
[
701,
24,
1105
],
[
1105,
1,
1386
]
],
[
[
701,
24,
1376
],
[
1376,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procyclidine"
]
],
[
[
"Clemastine",
"{u} (Compound) resembles {v} (Compound)",
"Cloperastine"
],
[
"Cloperastine",
"{u} (Compound) re... | Clemastine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Procyclidine (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl (Compound) resembles Procyclidine (Compound)
Clemastine may cause a moderat... |
DB08938 | DB09101 | 1,384 | 70 | [
"DDInter1112",
"DDInter633"
] | Magaldrate | Elvitegravir | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome ... | Moderate | 1 | [
[
[
1384,
24,
70
]
],
[
[
1384,
63,
1040
],
[
1040,
24,
70
]
],
[
[
1384,
62,
1220
],
[
1220,
24,
70
]
],
[
[
1384,
63,
1040
],
[
1040,
... | [
[
[
"Magaldrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elvitegravir"
]
],
[
[
"Magaldrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
],
[
... | Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Elvitegravir
Magaldrate may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dex... |
DB01181 | DB01319 | 1,532 | 34 | [
"DDInter906",
"DDInter777"
] | Ifosfamide | Fosamprenavir | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
1532,
24,
34
]
],
[
[
1532,
63,
1091
],
[
1091,
40,
34
]
],
[
[
1532,
6,
8374
],
[
8374,
45,
34
]
],
[
[
1532,
21,
28723
],
[
28723,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
[... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Ifosfamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Ifosfamide (Compound) causes Malnutrition (Side Effect) and ... |
DB00314 | DB09156 | 894 | 777 | [
"DDInter288",
"DDInter964"
] | Capreomycin | Iopromide | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Major | 2 | [
[
[
894,
25,
777
]
],
[
[
894,
24,
372
],
[
372,
25,
777
]
],
[
[
894,
25,
1132
],
[
1132,
25,
777
]
],
[
[
894,
24,
372
],
[
372,
6... | [
[
[
"Capreomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iopromide"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
"Clofarab... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may lead to a major life threatening interaction when taken with Iopromide
Capreomycin may lead to a major life threatening interaction when taken with Gentamicin and Gentamicin may lead to a major li... |
DB00279 | DB06723 | 1,152 | 115 | [
"DDInter1074",
"DDInter58"
] | Liothyronine | Aluminum hydroxide | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
1152,
24,
115
]
],
[
[
1152,
21,
28775
],
[
28775,
60,
115
]
],
[
[
1152,
24,
1482
],
[
1482,
23,
115
]
],
[
[
1152,
23,
461
],
[
461,... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Liothyronine",
"{u} (Compound) causes {v} (Side Effect)",
"Phlebitis"
],
[
"Phlebitis",
"{u} (Side Eff... | Liothyronine (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Aluminum hydroxide (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with... |
DB01238 | DB08820 | 673 | 1,478 | [
"DDInter118",
"DDInter997"
] | Aripiprazole | Ivacaftor | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
673,
24,
1478
]
],
[
[
673,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
673,
21,
29998
],
[
29998,
60,
1478
]
],
[
[
673,
63,
543
],
[
543,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Aripiprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Aripiprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Aripiprazole (Compound) causes Hyperaesthesia (Side Effect) and Hyperaesthesia (Side Effect) is caused by Ivacaftor (Compound)
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Loper... |
DB00860 | DB06372 | 891 | 259 | [
"DDInter1513",
"DDInter1594"
] | Prednisolone | Rilonacept | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
891,
24,
259
]
],
[
[
891,
23,
1114
],
[
1114,
62,
259
]
],
[
[
891,
62,
1461
],
[
1461,
23,
259
]
],
[
[
891,
24,
1619
],
[
1619,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
... | Prednisolone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitam... |
DB00765 | DB11186 | 1,266 | 1,609 | [
"DDInter1205",
"DDInter1427"
] | Metyrosine | Pentoxyverine | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1266,
24,
1609
]
],
[
[
1266,
24,
104
],
[
104,
24,
1609
]
],
[
[
1266,
63,
999
],
[
999,
24,
1609
]
],
[
[
1266,
24,
104
],
[
104,
... | [
[
[
"Metyrosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Metyrosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazi... |
DB01118 | DB01142 | 33 | 1,264 | [
"DDInter76",
"DDInter593"
] | Amiodarone | Doxepin | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
33,
25,
1264
]
],
[
[
33,
64,
401
],
[
401,
24,
1264
]
],
[
[
33,
6,
4973
],
[
4973,
45,
1264
]
],
[
[
33,
7,
6952
],
[
6952,
46... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
],
[
"Promethazine",
"{u} ... | Amiodarone may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Amiodarone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxepin (Compound)
Amiodarone (Compound) upregulates MCO... |
DB00556 | DB00694 | 1,262 | 51 | [
"DDInter1429",
"DDInter485"
] | Perflutren | Daunorubicin | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Moderate | 1 | [
[
[
1262,
24,
51
]
],
[
[
1262,
21,
29473
],
[
29473,
60,
51
]
],
[
[
1262,
23,
112
],
[
112,
62,
51
]
],
[
[
1262,
24,
1557
],
[
1557,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]
],
[
[
"Perflutren",
"{u} (Compound) causes {v} (Side Effect)",
"Induration"
],
[
"Induration",
"{u} (Side Effect) is ... | Perflutren (Compound) causes Induration (Side Effect) and Induration (Side Effect) is caused by Daunorubicin (Compound)
Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with D... |
DB00968 | DB09112 | 1,551 | 1,455 | [
"DDInter1185",
"DDInter1306"
] | Methyldopa | Nitrous acid | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
1551,
24,
1455
]
],
[
[
1551,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
1551,
24,
433
],
[
433,
63,
1455
]
],
[
[
1551,
63,
1061
],
[
1061... | [
[
[
"Methyldopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Methyldopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
... | Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin... |
DB01611 | DB09330 | 1,487 | 985 | [
"DDInter893",
"DDInter1352"
] | Hydroxychloroquine | Osimertinib | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1487,
25,
985
]
],
[
[
1487,
63,
168
],
[
168,
23,
985
]
],
[
[
1487,
62,
1247
],
[
1247,
23,
985
]
],
[
[
1487,
63,
134
],
[
134,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sulfamet... |
DB00775 | DB14006 | 1,226 | 972 | [
"DDInter1818",
"DDInter370"
] | Tirofiban | Choline salicylate | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1226,
24,
972
]
],
[
[
1226,
64,
553
],
[
553,
24,
972
]
],
[
[
1226,
24,
885
],
[
885,
24,
972
]
],
[
[
1226,
63,
1061
],
[
1061,
... | [
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
],
[
"Fo... | Tirofiban may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoproste... |
DB01218 | DB09078 | 1,493 | 1,228 | [
"DDInter852",
"DDInter1036"
] | Halofantrine | Lenvatinib | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1493,
25,
1228
]
],
[
[
1493,
62,
112
],
[
112,
23,
1228
]
],
[
[
1493,
64,
1100
],
[
1100,
24,
1228
]
],
[
[
1493,
25,
938
],
[
938,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Halofantrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Halofantrine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Halofantrine may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxine ma... |
DB00067 | DB05294 | 317 | 1,069 | [
"DDInter1921",
"DDInter1917"
] | Vasopressin | Vandetanib | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
317,
25,
1069
]
],
[
[
317,
23,
112
],
[
112,
23,
1069
]
],
[
[
317,
24,
659
],
[
659,
63,
1069
]
],
[
[
317,
24,
688
],
[
688,
... | [
[
[
"Vasopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Vasopressin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vandetanib
Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vi... |
DB02959 | DB09241 | 871 | 1,629 | [
"DDInter1362",
"DDInter1186"
] | Oxitriptan | Methylene blue | 5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressa... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
871,
25,
1629
]
],
[
[
871,
63,
475
],
[
475,
25,
1629
]
],
[
[
871,
64,
1133
],
[
1133,
25,
1629
]
],
[
[
871,
40,
1191
],
[
1191,
... | [
[
[
"Oxitriptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Oxitriptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
"Morphine... | Oxitriptan may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening interaction when taken with Methylene blue
Oxitriptan may lead to a major life threatening interaction when taken with Granisetron and Granisetron may lead to a major lif... |
DB00196 | DB01394 | 600 | 1,554 | [
"DDInter743",
"DDInter431"
] | Fluconazole | Colchicine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Major | 2 | [
[
[
600,
25,
1554
]
],
[
[
600,
6,
4973
],
[
4973,
45,
1554
]
],
[
[
600,
54,
19146
],
[
19146,
15,
1554
]
],
[
[
600,
7,
7885
],
[
7885,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Colchicine"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Colchic... | Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Colchicine (Compound)
Fluconazole (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Colchicine (Compound)
Fluconazole (Compound) upregulates MELK (Gene) a... |
DB00831 | DB00855 | 1,178 | 213 | [
"DDInter1866",
"DDInter72"
] | Trifluoperazine | Aminolevulinic acid | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Major | 2 | [
[
[
1178,
25,
213
]
],
[
[
1178,
7,
7669
],
[
7669,
46,
213
]
],
[
[
1178,
21,
28766
],
[
28766,
60,
213
]
],
[
[
1178,
63,
1419
],
[
1419... | [
[
[
"Trifluoperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aminolevulinic acid"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) upregulates {v} (Gene)",
"DDIT4"
],
[
"DDIT4",
"{u} (Gene) is upregulated by {v... | Trifluoperazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Aminolevulinic acid (Compound)
Trifluoperazine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Aminolevulinic acid (Compound)
Trifluoperazine may cause a moderate interaction that could exacerba... |
DB00331 | DB00414 | 1,645 | 590 | [
"DDInter1164",
"DDInter16"
] | Metformin | Acetohexamide | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
1645,
24,
590
]
],
[
[
1645,
62,
1103
],
[
1103,
23,
590
]
],
[
[
1645,
24,
651
],
[
651,
63,
590
]
],
[
[
1645,
63,
168
],
[
168,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Metformin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
... | Metformin may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Acetohexamide
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphen... |
DB00030 | DB01364 | 1,685 | 22 | [
"DDInter934",
"DDInter650"
] | Insulin human | Ephedrine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1685,
24,
22
]
],
[
[
1685,
24,
1529
],
[
1529,
63,
22
]
],
[
[
1685,
24,
1445
],
[
1445,
1,
22
]
],
[
[
1685,
24,
1220
],
[
1220,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephe... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.