drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00927 | DB01267 | 1,559 | 519 | [
"DDInter712",
"DDInter1381"
] | Famotidine | Paliperidone | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1559,
24,
519
]
],
[
[
1559,
63,
1664
],
[
1664,
1,
519
]
],
[
[
1559,
24,
924
],
[
924,
1,
519
]
],
[
[
1559,
21,
28898
],
[
28898,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (Co... |
DB00011 | DB08908 | 1,451 | 713 | [
"DDInter944",
"DDInter564"
] | Interferon alfa-n1 | Dimethyl fumarate | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1451,
24,
713
]
],
[
[
1451,
24,
996
],
[
996,
24,
713
]
],
[
[
1451,
24,
270
],
[
270,
63,
713
]
],
[
[
1451,
63,
491
],
[
491,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Beda... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01240 | DB09237 | 885 | 1,586 | [
"DDInter657",
"DDInter1045"
] | Epoprostenol | Levamlodipine | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
885,
24,
1586
]
],
[
[
885,
24,
578
],
[
578,
23,
1586
]
],
[
[
885,
63,
1648
],
[
1648,
24,
1586
]
],
[
[
885,
24,
549
],
[
549,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
... | Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and ... |
DB01177 | DB15091 | 77 | 676 | [
"DDInter904",
"DDInter1901"
] | Idarubicin | Upadacitinib | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
77,
25,
676
]
],
[
[
77,
63,
1461
],
[
1461,
23,
676
]
],
[
[
77,
24,
1430
],
[
1430,
24,
676
]
],
[
[
77,
25,
1593
],
[
1593,
2... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipule... |
DB00865 | DB01191 | 939 | 1,039 | [
"DDInter187",
"DDInter518"
] | Benzphetamine | Dexfenfluramine | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
939,
25,
1039
]
],
[
[
939,
40,
1529
],
[
1529,
64,
1039
]
],
[
[
939,
40,
11447
],
[
11447,
1,
1039
]
],
[
[
939,
24,
1130
],
[
1130,... | [
[
[
"Benzphetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Benzphetamine",
"{u} (Compound) resembles {v} (Compound)",
"Metamfetamine"
],
[
"Metamfetamine",
"{u} may lead to a maj... | Benzphetamine (Compound) resembles Metamfetamine (Compound) and Metamfetamine may lead to a major life threatening interaction when taken with Dexfenfluramine
Benzphetamine (Compound) resembles Fenproporex (Compound) and Fenproporex (Compound) resembles Dexfenfluramine (Compound)
Benzphetamine may cause a moderate inte... |
DB00280 | DB00468 | 494 | 1,424 | [
"DDInter575",
"DDInter1557"
] | Disopyramide | Quinine | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Major | 2 | [
[
[
494,
25,
1424
]
],
[
[
494,
6,
8803
],
[
8803,
45,
1424
]
],
[
[
494,
21,
28709
],
[
28709,
60,
1424
]
],
[
[
494,
23,
112
],
[
112,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
]
],
[
[
"Disopyramide",
"{u} (Compound) binds {v} (Gene)",
"SLC22A2"
],
[
"SLC22A2",
"{u} (Gene) is bound by {v} (Compound)",
"Quin... | Disopyramide (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Quinine (Compound)
Disopyramide (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Quinine (Compound)
Disopyramide may cause a minor interaction that can limit clinical effects when taken with M... |
DB00907 | DB01438 | 290 | 585 | [
"DDInter427",
"DDInter1438"
] | Cocaine (topical) | Phenazopyridine | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. It is still us... | Moderate | 1 | [
[
[
290,
24,
585
]
],
[
[
290,
6,
14890
],
[
14890,
45,
585
]
],
[
[
290,
21,
28658
],
[
28658,
60,
585
]
],
[
[
290,
21,
28658
],
[
28658... | [
[
[
"Cocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenazopyridine"
]
],
[
[
"Cocaine",
"{u} (Compound) binds {v} (Gene)",
"SCN11A"
],
[
"SCN11A",
"{u} (Gene) is bound by {v} (Compound)",
... | Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Phenazopyridine
Cocaine (Compound) binds SCN11A (Gene) and SCN11A (Gene) is bound by Phenazopyridine (Compound)
Cocaine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Phenazopyridine (Compound)
Coca... |
DB01284 | DB04865 | 1,042 | 4 | [
"DDInter1782",
"DDInter1335"
] | Tetracosactide | Omacetaxine mepesuccinate | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1042,
24,
4
]
],
[
[
1042,
24,
496
],
[
496,
63,
4
]
],
[
[
1042,
63,
66
],
[
66,
24,
4
]
],
[
[
1042,
24,
1254
],
[
1254,
24,
... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepa... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Tetracosactide may cause a moderate interaction that could exacerbate disea... |
DB00434 | DB01176 | 13 | 537 | [
"DDInter459",
"DDInter453"
] | Cyproheptadine | Cyclizine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
13,
24,
537
]
],
[
[
13,
24,
1511
],
[
1511,
63,
537
]
],
[
[
13,
40,
11286
],
[
11286,
1,
537
]
],
[
[
13,
63,
1242
],
[
1242,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Cyproheptadine (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) resembles C... |
DB06643 | DB08870 | 1,136 | 850 | [
"DDInter500",
"DDInter228"
] | Denosumab | Brentuximab vedotin | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1136,
24,
850
]
],
[
[
1136,
63,
611
],
[
611,
24,
850
]
],
[
[
1136,
24,
1583
],
[
1583,
63,
850
]
],
[
[
1136,
24,
310
],
[
310,
... | [
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
],
... | Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine and Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab an... |
DB00488 | DB08908 | 196 | 713 | [
"DDInter57",
"DDInter564"
] | Altretamine | Dimethyl fumarate | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
196,
24,
713
]
],
[
[
196,
24,
4
],
[
4,
24,
713
]
],
[
[
196,
24,
270
],
[
270,
63,
713
]
],
[
[
196,
63,
1184
],
[
1184,
24,
... | [
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesu... | Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Altretamine may cause a moderate interaction that could exacerbate disease... |
DB00889 | DB11915 | 1,133 | 1,293 | [
"DDInter840",
"DDInter1909"
] | Granisetron | Valbenazine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1133,
24,
1293
]
],
[
[
1133,
23,
112
],
[
112,
23,
1293
]
],
[
[
1133,
63,
521
],
[
521,
24,
1293
]
],
[
[
1133,
24,
401
],
[
401,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Granisetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Granisetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Go... |
DB01173 | DB09272 | 358 | 412 | [
"DDInter1349",
"DDInter632"
] | Orphenadrine | Eluxadoline | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
358,
24,
412
]
],
[
[
358,
63,
1594
],
[
1594,
24,
412
]
],
[
[
358,
24,
830
],
[
830,
24,
412
]
],
[
[
358,
64,
475
],
[
475,
2... | [
[
[
"Orphenadrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Orphenadrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and... |
DB01284 | DB09020 | 1,042 | 28 | [
"DDInter1782",
"DDInter212"
] | Tetracosactide | Bisacodyl | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1042,
24,
28
]
],
[
[
1042,
63,
954
],
[
954,
24,
28
]
],
[
[
1042,
64,
932
],
[
932,
24,
28
]
],
[
[
1042,
24,
607
],
[
607,
24... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
],
... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Tetracosactide may lead to a major life threatening interaction when taken with Mifepristone and Mifepristone m... |
DB00334 | DB06699 | 867 | 774 | [
"DDInter1326",
"DDInter493"
] | Olanzapine | Degarelix | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
867,
24,
774
]
],
[
[
867,
63,
521
],
[
521,
1,
774
]
],
[
[
867,
23,
112
],
[
112,
23,
774
]
],
[
[
867,
24,
888
],
[
888,
24,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Olanzapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can lim... |
DB00420 | DB00515 | 508 | 589 | [
"DDInter1532",
"DDInter387"
] | Promazine | Cisplatin | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
508,
24,
589
]
],
[
[
508,
6,
6017
],
[
6017,
45,
589
]
],
[
[
508,
1,
684
],
[
684,
63,
589
]
],
[
[
508,
24,
77
],
[
77,
63,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Promazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Promazine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cisplatin (Compound)
Promazine (Compound) resembles Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin
Promazine may cause a moderate interaction that could exacerbate d... |
DB00975 | DB10344 | 1,317 | 992 | [
"DDInter573",
"DDInter818"
] | Dipyridamole | Ginger | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Ginger allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
1317,
24,
992
]
],
[
[
1317,
64,
1578
],
[
1578,
24,
992
]
],
[
[
1317,
25,
1421
],
[
1421,
63,
992
]
],
[
[
1317,
63,
1167
],
[
1167,... | [
[
[
"Dipyridamole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginger"
]
],
[
[
"Dipyridamole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lepirudin"
],
[
"Lepirudin",... | Dipyridamole may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ginger
Dipyridamole may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moderate intera... |
DB09498 | DB12001 | 810 | 564 | [
"DDInter1715",
"DDInter7"
] | Strontium chloride Sr-89 | Abemaciclib | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
810,
24,
564
]
],
[
[
810,
63,
1213
],
[
1213,
24,
564
]
],
[
[
810,
24,
351
],
[
351,
24,
564
]
],
[
[
810,
24,
1259
],
[
1259,
... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken... |
DB00295 | DB00962 | 475 | 1,639 | [
"DDInter1244",
"DDInter1957"
] | Morphine | Zaleplon | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. | Major | 2 | [
[
[
475,
25,
1639
]
],
[
[
475,
6,
8374
],
[
8374,
45,
1639
]
],
[
[
475,
21,
28891
],
[
28891,
60,
1639
]
],
[
[
475,
24,
13
],
[
13,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zaleplon"
]
],
[
[
"Morphine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Zaleplon"
... | Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zaleplon (Compound)
Morphine (Compound) causes Hypertonia (Side Effect) and Hypertonia (Side Effect) is caused by Zaleplon (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyprohep... |
DB00501 | DB01416 | 752 | 1,024 | [
"DDInter380",
"DDInter326"
] | Cimetidine | Cefpodoxime | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. | Moderate | 1 | [
[
[
752,
24,
1024
]
],
[
[
752,
24,
665
],
[
665,
40,
1024
]
],
[
[
752,
24,
1462
],
[
1462,
1,
1024
]
],
[
[
752,
21,
29044
],
[
29044,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefpodoxime"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Cefpodoxime (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Cefpodoxime (Compound... |
DB00295 | DB09118 | 475 | 1,580 | [
"DDInter1244",
"DDInter1711"
] | Morphine | Stiripentol | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
475,
24,
1580
]
],
[
[
475,
24,
1532
],
[
1532,
24,
1580
]
],
[
[
475,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
475,
63,
701
],
[
701,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pentox... |
DB00731 | DB01234 | 1,144 | 1,220 | [
"DDInter1269",
"DDInter513"
] | Nateglinide | Dexamethasone | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1144,
24,
1220
]
],
[
[
1144,
63,
870
],
[
870,
1,
1220
]
],
[
[
1144,
63,
175
],
[
175,
40,
1220
]
],
[
[
1144,
24,
167
],
[
167,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles D... |
DB01259 | DB04908 | 392 | 1,671 | [
"DDInter1024",
"DDInter741"
] | Lapatinib | Flibanserin | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
392,
24,
1671
]
],
[
[
392,
23,
1135
],
[
1135,
62,
1671
]
],
[
[
392,
24,
741
],
[
741,
63,
1671
]
],
[
[
392,
63,
303
],
[
303,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Lapatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Lapatinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Flibanserin
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant ma... |
DB00549 | DB08899 | 522 | 129 | [
"DDInter1955",
"DDInter649"
] | Zafirlukast | Enzalutamide | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
522,
24,
129
]
],
[
[
522,
6,
8374
],
[
8374,
45,
129
]
],
[
[
522,
21,
28703
],
[
28703,
60,
129
]
],
[
[
522,
23,
271
],
[
271,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Zafirlukast (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Mirabegron and M... |
DB00002 | DB00213 | 1,284 | 837 | [
"DDInter344",
"DDInter1388"
] | Cetuximab | Pantoprazole | Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it... | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Moderate | 1 | [
[
[
1284,
24,
837
]
],
[
[
1284,
24,
1215
],
[
1215,
40,
837
]
],
[
[
1284,
24,
589
],
[
589,
63,
837
]
],
[
[
1284,
24,
1215
],
[
1215,
... | [
[
[
"Cetuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pantoprazole"
]
],
[
[
"Cetuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
... | Cetuximab may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Pantoprazole (Compound)
Cetuximab may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that cou... |
DB01259 | DB04845 | 392 | 309 | [
"DDInter1024",
"DDInter1001"
] | Lapatinib | Ixabepilone | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
392,
24,
309
]
],
[
[
392,
5,
11579
],
[
11579,
44,
309
]
],
[
[
392,
6,
8374
],
[
8374,
45,
309
]
],
[
[
392,
21,
28736
],
[
28736,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Lapatinib",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treat... | Lapatinib (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Ixabepilone (Compound)
Lapatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Lapatinib (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone ... |
DB01082 | DB01330 | 1,448 | 1,402 | [
"DDInter1713",
"DDInter324"
] | Streptomycin | Cefotetan | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. | Moderate | 1 | [
[
[
1448,
24,
1402
]
],
[
[
1448,
24,
1124
],
[
1124,
1,
1402
]
],
[
[
1448,
24,
1558
],
[
1558,
40,
1402
]
],
[
[
1448,
63,
277
],
[
277,... | [
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefotetan"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefamandole"
],
... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefamandole and Cefamandole (Compound) resembles Cefotetan (Compound)
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefoxitin and Cefoxitin (Compound) resembles Cefotetan (Compound... |
DB01181 | DB01215 | 1,532 | 1,418 | [
"DDInter906",
"DDInter677"
] | Ifosfamide | Estazolam | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
1532,
24,
1418
]
],
[
[
1532,
63,
523
],
[
523,
1,
1418
]
],
[
[
1532,
63,
1216
],
[
1216,
40,
1418
]
],
[
[
1532,
24,
481
],
[
481,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
If... |
DB00831 | DB06292 | 1,178 | 549 | [
"DDInter1866",
"DDInter474"
] | Trifluoperazine | Dapagliflozin | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1178,
24,
549
]
],
[
[
1178,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1178,
6,
4973
],
[
4973,
45,
549
]
],
[
[
1178,
21,
29222
],
[
29222... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Trifluoperazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dapagliflozin (Compound)
Trifluoperazine (Compound) causes Hypoglycaemi... |
DB14723 | DB14881 | 159 | 180 | [
"DDInter1026",
"DDInter1329"
] | Larotrectinib | Oliceridine | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
159,
24,
180
]
],
[
[
159,
63,
1094
],
[
1094,
24,
180
]
],
[
[
159,
62,
222
],
[
222,
24,
180
]
],
[
[
159,
63,
1040
],
[
1040,
... | [
[
[
"Larotrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Larotrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
... | Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Larotrectinib may cause a minor interaction that can limit clinical effects when taken with Sibutramine an... |
DB00852 | DB14754 | 1,445 | 1,663 | [
"DDInter1545",
"DDInter1697"
] | Pseudoephedrine | Solriamfetol | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label]. | Moderate | 1 | [
[
[
1445,
24,
1663
]
],
[
[
1445,
63,
1674
],
[
1674,
24,
1663
]
],
[
[
1445,
24,
1148
],
[
1148,
24,
1663
]
],
[
[
1445,
1,
22
],
[
22,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solriamfetol"
]
],
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
... | Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Solriamfetol
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Iso... |
DB01030 | DB05679 | 869 | 1,683 | [
"DDInter1835",
"DDInter1907"
] | Topotecan | Ustekinumab | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
869,
24,
1683
]
],
[
[
869,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
869,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
869,
63,
281
],
[
281,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may ... |
DB00745 | DB08865 | 307 | 1,593 | [
"DDInter1236",
"DDInter448"
] | Modafinil | Crizotinib | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Minor | 0 | [
[
[
307,
23,
1593
]
],
[
[
307,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
307,
18,
10375
],
[
10375,
57,
1593
]
],
[
[
307,
21,
29093
],
[
2909... | [
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Crizotinib"
]
],
[
[
"Modafinil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Modafinil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Modafinil (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Crizotinib (Compound)
Modafinil (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Modafin... |
DB01238 | DB09043 | 673 | 135 | [
"DDInter118",
"DDInter36"
] | Aripiprazole | Albiglutide | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
673,
24,
135
]
],
[
[
673,
63,
1647
],
[
1647,
23,
135
]
],
[
[
673,
63,
176
],
[
176,
24,
135
]
],
[
[
673,
24,
820
],
[
820,
2... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and I... |
DB00912 | DB12130 | 473 | 1,017 | [
"DDInter1581",
"DDInter1094"
] | Repaglinide | Lorlatinib | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
473,
24,
1017
]
],
[
[
473,
24,
1612
],
[
1612,
23,
1017
]
],
[
[
473,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
473,
63,
175
],
[
175,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexa... |
DB00245 | DB00804 | 357 | 1,507 | [
"DDInter181",
"DDInter543"
] | Benzatropine | Dicyclomine | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
357,
24,
1507
]
],
[
[
357,
6,
7992
],
[
7992,
45,
1507
]
],
[
[
357,
21,
28817
],
[
28817,
60,
1507
]
],
[
[
357,
24,
1021
],
[
1021,... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Benzatropine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound... | Benzatropine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Dicyclomine (Compound)
Benzatropine (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Dicyclomine (Compound)
Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Pra... |
DB06589 | DB13879 | 1,250 | 1,043 | [
"DDInter1400",
"DDInter824"
] | Pazopanib | Glecaprevir | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with , glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic ba... | Major | 2 | [
[
[
1250,
25,
1043
]
],
[
[
1250,
23,
1135
],
[
1135,
23,
1043
]
],
[
[
1250,
63,
353
],
[
353,
24,
1043
]
],
[
[
1250,
24,
466
],
[
466,
... | [
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glecaprevir"
]
],
[
[
"Pazopanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Pazopanib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glecaprevir
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvi... |
DB00673 | DB00918 | 723 | 1,373 | [
"DDInter112",
"DDInter49"
] | Aprepitant | Almotriptan | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that ... | Moderate | 1 | [
[
[
723,
24,
1373
]
],
[
[
723,
6,
10215
],
[
10215,
45,
1373
]
],
[
[
723,
21,
29152
],
[
29152,
60,
1373
]
],
[
[
723,
24,
1213
],
[
121... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Almotriptan"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound... | Aprepitant (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Almotriptan (Compound)
Aprepitant (Compound) causes Thirst (Side Effect) and Thirst (Side Effect) is caused by Almotriptan (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatin... |
DB09472 | DB11642 | 1,383 | 938 | [
"DDInter1693",
"DDInter1480"
] | Sodium sulfate | Pitolisant | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1383,
24,
938
]
],
[
[
1383,
63,
28
],
[
28,
24,
938
]
],
[
[
1383,
64,
1181
],
[
1181,
24,
938
]
],
[
[
1383,
24,
927
],
[
927,
... | [
[
[
"Sodium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Sodium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
],
... | Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Sodium sulfate may lead to a major life threatening interaction when taken with Terfenadine and Terfenadine ma... |
DB06335 | DB06791 | 761 | 1,446 | [
"DDInter1646",
"DDInter1021"
] | Saxagliptin | Lanreotide | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
761,
24,
1446
]
],
[
[
761,
24,
154
],
[
154,
63,
1446
]
],
[
[
761,
24,
655
],
[
655,
24,
1446
]
],
[
[
761,
63,
1324
],
[
1324,
... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
],
[
... | Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etra... |
DB00204 | DB00687 | 228 | 870 | [
"DDInter580",
"DDInter747"
] | Dofetilide | Fludrocortisone | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Major | 2 | [
[
[
228,
25,
870
]
],
[
[
228,
23,
1220
],
[
1220,
40,
870
]
],
[
[
228,
25,
167
],
[
167,
40,
870
]
],
[
[
228,
21,
28936
],
[
28936,
... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Dofetilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
[
"Dexa... | Dofetilide may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Dofetilide may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Fludrocortisone (Com... |
DB01035 | DB11057 | 1,401 | 720 | [
"DDInter1524",
"DDInter1223"
] | Procainamide | Mineral oil | A derivative of procaine with less CNS action. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1401,
24,
720
]
],
[
[
1401,
25,
927
],
[
927,
63,
720
]
],
[
[
1401,
36,
1151
],
[
1151,
24,
720
]
],
[
[
1401,
25,
1069
],
[
1069,
... | [
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Enco... | Procainamide may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Procainamide (Compound) resembles Sunitinib (Compound) and Procainamide may lead to a major life threatening interaction w... |
DB00106 | DB11915 | 618 | 1,293 | [
"DDInter4",
"DDInter1909"
] | Abarelix | Valbenazine | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
618,
24,
1293
]
],
[
[
618,
23,
112
],
[
112,
23,
1293
]
],
[
[
618,
24,
401
],
[
401,
24,
1293
]
],
[
[
618,
24,
1619
],
[
1619,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prome... |
DB01185 | DB01309 | 155 | 1,254 | [
"DDInter759",
"DDInter933"
] | Fluoxymesterone | Insulin glulisine | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
155,
24,
1254
]
],
[
[
155,
40,
1103
],
[
1103,
23,
1254
]
],
[
[
155,
74,
167
],
[
167,
24,
1254
]
],
[
[
155,
35,
1220
],
[
1220,
... | [
[
[
"Fluoxymesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Fluoxymesterone",
"{u} (Compound) resembles {v} (Compound)",
"Amcinonide"
],
[
"Amcinonide",
"{u} ma... | Fluoxymesterone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Fluoxymesterone (Compound) resembles Hydrocortisone (Compound) and Fluoxymesterone may cause a moderate interaction that could exacerbate diseases whe... |
DB09074 | DB15044 | 1,362 | 631 | [
"DDInter1327",
"DDInter1738"
] | Olaparib | Tafasitamab | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies. It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which has been modified with 2 amino acid substitutions to enhance its cytoto... | Moderate | 1 | [
[
[
1362,
24,
631
]
],
[
[
1362,
63,
4
],
[
4,
24,
631
]
],
[
[
1362,
24,
810
],
[
810,
24,
631
]
],
[
[
1362,
64,
976
],
[
976,
25,... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tafasitamab"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Tafasitamab
Olaparib may cause a moderate interaction that could exacerbate diseases when taken... |
DB00047 | DB00819 | 176 | 471 | [
"DDInter932",
"DDInter15"
] | Insulin glargine | Acetazolamide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Moderate | 1 | [
[
[
176,
24,
471
]
],
[
[
176,
24,
997
],
[
997,
40,
471
]
],
[
[
176,
24,
1545
],
[
1545,
23,
471
]
],
[
[
176,
24,
1669
],
[
1669,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetazolamide"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methazolamid... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Methazolamide and Methazolamide (Compound) resembles Acetazolamide (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Oxytetracycline and Oxytetracycline may cause a ... |
DB01105 | DB01278 | 222 | 1,021 | [
"DDInter1665",
"DDInter1506"
] | Sibutramine | Pramlintide | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
222,
24,
1021
]
],
[
[
222,
63,
1680
],
[
1680,
24,
1021
]
],
[
[
222,
62,
839
],
[
839,
24,
1021
]
],
[
[
222,
64,
1466
],
[
1466,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etacrynic acid"
],
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Etacrynic acid and Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Sibutramine may cause a minor interaction that can limit clinical effects when taken with Grepafloxaci... |
DB00918 | DB12130 | 1,373 | 1,017 | [
"DDInter49",
"DDInter1094"
] | Almotriptan | Lorlatinib | Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1373,
24,
1017
]
],
[
[
1373,
63,
629
],
[
629,
24,
1017
]
],
[
[
1373,
24,
214
],
[
214,
24,
1017
]
],
[
[
1373,
25,
222
],
[
222,
... | [
[
[
"Almotriptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Almotriptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
... | Almotriptan may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Almotriptan may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fost... |
DB00673 | DB14840 | 723 | 861 | [
"DDInter112",
"DDInter1601"
] | Aprepitant | Ripretinib | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
723,
24,
861
]
],
[
[
723,
24,
351
],
[
351,
24,
861
]
],
[
[
723,
63,
353
],
[
353,
24,
861
]
],
[
[
723,
25,
1456
],
[
1456,
2... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Gris... |
DB00059 | DB00900 | 1,560 | 45 | [
"DDInter1404",
"DDInter544"
] | Pegaspargase | Didanosine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Moderate | 1 | [
[
[
1560,
24,
45
]
],
[
[
1560,
24,
1620
],
[
1620,
23,
45
]
],
[
[
1560,
24,
1669
],
[
1669,
62,
45
]
],
[
[
1560,
24,
1142
],
[
1142,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline may cause a minor interaction that can limit clinical effects when taken with Didanosine
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Minocycline and... |
DB00322 | DB00631 | 141 | 372 | [
"DDInter742",
"DDInter405"
] | Floxuridine | Clofarabine | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
141,
24,
372
]
],
[
[
141,
64,
1064
],
[
1064,
25,
372
]
],
[
[
141,
24,
1488
],
[
1488,
40,
372
]
],
[
[
141,
1,
903
],
[
903,
... | [
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cladrib... | Floxuridine may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Clofarabine
Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine (Compound) resembles... |
DB00514 | DB00794 | 506 | 759 | [
"DDInter527",
"DDInter1521"
] | Dextromethorphan | Primidone | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
506,
24,
759
]
],
[
[
506,
24,
697
],
[
697,
40,
759
]
],
[
[
506,
63,
362
],
[
362,
1,
759
]
],
[
[
506,
24,
157
],
[
157,
1,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primido... |
DB00569 | DB10897 | 553 | 539 | [
"DDInter775",
"DDInter291"
] | Fondaparinux | Capsicum | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Capsicum (Chili pepper) allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
553,
23,
539
]
],
[
[
553,
25,
885
],
[
885,
23,
539
]
],
[
[
553,
64,
702
],
[
702,
23,
539
]
],
[
[
553,
25,
1421
],
[
1421,
6... | [
[
[
"Fondaparinux",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
],
[
"Epoprost... | Fondaparinux may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum
Fondaparinux may lead to a major life threatening interaction when taken with Anagrelide and Anagrelide may cause a minor int... |
DB09039 | DB15982 | 1,670 | 1,339 | [
"DDInter629",
"DDInter193"
] | Eliglustat | Berotralstat | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
1670,
25,
1339
]
],
[
[
1670,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
1670,
25,
283
],
[
283,
23,
1339
]
],
[
[
1670,
63,
1213
],
[
1213... | [
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Eliglustat may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause ... |
DB00281 | DB01182 | 608 | 371 | [
"DDInter1066",
"DDInter1534"
] | Lidocaine | Propafenone | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Minor | 0 | [
[
[
608,
23,
371
]
],
[
[
608,
24,
772
],
[
772,
40,
371
]
],
[
[
608,
6,
6017
],
[
6017,
45,
371
]
],
[
[
608,
21,
28659
],
[
28659,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Propafenone"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Carvedilol (Compound) resembles Propafenone (Compound)
Lidocaine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Propafenone (Compound)
Lidocaine (Compound) causes Urinary incontinence (Side Effect) and... |
DB04932 | DB10672 | 1,564 | 297 | [
"DDInter491",
"DDInter417"
] | Defibrotide | Clove | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
1564,
23,
297
]
],
[
[
1564,
25,
235
],
[
235,
62,
297
]
],
[
[
1564,
25,
578
],
[
578,
23,
297
]
],
[
[
1564,
64,
366
],
[
366,
... | [
[
[
"Defibrotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Defibrotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
... | Defibrotide may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Defibrotide may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a minor interaction th... |
DB00777 | DB06282 | 146 | 516 | [
"DDInter1537",
"DDInter1053"
] | Propiomazine | Levocetirizine | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
146,
24,
516
]
],
[
[
146,
63,
701
],
[
701,
24,
516
]
],
[
[
146,
40,
1178
],
[
1178,
24,
516
]
],
[
[
146,
1,
1301
],
[
1301,
... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Propiomazine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine may cause a moderate inte... |
DB00831 | DB13074 | 1,178 | 877 | [
"DDInter1866",
"DDInter1110"
] | Trifluoperazine | Macimorelin | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1178,
25,
877
]
],
[
[
1178,
23,
112
],
[
112,
23,
877
]
],
[
[
1178,
63,
85
],
[
85,
24,
877
]
],
[
[
1178,
24,
913
],
[
913,
2... | [
[
[
"Trifluoperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Atropine... |
DB00001 | DB00328 | 1,578 | 831 | [
"DDInter1037",
"DDInter921"
] | Lepirudin | Indomethacin | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Moderate | 1 | [
[
[
1578,
24,
831
]
],
[
[
1578,
24,
1263
],
[
1263,
1,
831
]
],
[
[
1578,
24,
848
],
[
848,
63,
831
]
],
[
[
1578,
25,
20
],
[
20,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indomethacin"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
],
[
... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac (Compound) resembles Indomethacin (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exa... |
DB05351 | DB11952 | 101 | 800 | [
"DDInter519",
"DDInter612"
] | Dexlansoprazole | Duvelisib | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
101,
24,
800
]
],
[
[
101,
64,
663
],
[
663,
24,
800
]
],
[
[
101,
63,
126
],
[
126,
24,
800
]
],
[
[
101,
23,
263
],
[
263,
24,... | [
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Dexlansoprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrexate"
],
[
... | Dexlansoprazole may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin m... |
DB00976 | DB06699 | 1,056 | 774 | [
"DDInter1758",
"DDInter493"
] | Telithromycin | Degarelix | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
1056,
24,
774
]
],
[
[
1056,
63,
521
],
[
521,
1,
774
]
],
[
[
1056,
21,
29232
],
[
29232,
60,
774
]
],
[
[
1056,
62,
112
],
[
112,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Telithromycin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Telithromycin may cause a minor interactio... |
DB00358 | DB01158 | 1,010 | 1,286 | [
"DDInter1140",
"DDInter229"
] | Mefloquine | Bretylium | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of vol... | Moderate | 1 | [
[
[
1010,
24,
1286
]
],
[
[
1010,
21,
29541
],
[
29541,
60,
1286
]
],
[
[
1010,
63,
608
],
[
608,
24,
1286
]
],
[
[
1010,
21,
28653
],
[
2... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bretylium"
]
],
[
[
"Mefloquine",
"{u} (Compound) causes {v} (Side Effect)",
"Paranoia"
],
[
"Paranoia",
"{u} (Side Effect) is caused ... | Mefloquine (Compound) causes Paranoia (Side Effect) and Paranoia (Side Effect) is caused by Bretylium (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Bretylium
Me... |
DB00279 | DB01365 | 1,152 | 280 | [
"DDInter1074",
"DDInter1151"
] | Liothyronine | Mephentermine | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Moderate | 1 | [
[
[
1152,
24,
280
]
],
[
[
1152,
63,
80
],
[
80,
40,
280
]
],
[
[
1152,
24,
1445
],
[
1445,
1,
280
]
],
[
[
1152,
1,
11215
],
[
11215,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephentermine"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Mephentermine (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Mep... |
DB00927 | DB01087 | 1,559 | 1,520 | [
"DDInter712",
"DDInter1520"
] | Famotidine | Primaquine | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
1559,
24,
1520
]
],
[
[
1559,
24,
1487
],
[
1487,
64,
1520
]
],
[
[
1559,
21,
28722
],
[
28722,
60,
1520
]
],
[
[
1559,
62,
112
],
[
1... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Famotidine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Primaquine (Compound)
F... |
DB00475 | DB09104 | 1,119 | 286 | [
"DDInter355",
"DDInter1118"
] | Chlordiazepoxide | Magnesium hydroxide | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
1119,
23,
286
]
],
[
[
1119,
24,
820
],
[
820,
23,
286
]
],
[
[
1119,
40,
1382
],
[
1382,
23,
286
]
],
[
[
1119,
63,
999
],
[
999,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemaz... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Chlordiazepoxide (Compound) resembles Midazolam (Compound) and Midazolam may cause a minor intera... |
DB00382 | DB09122 | 62 | 1,613 | [
"DDInter1734",
"DDInter1409"
] | Tacrine | Peginterferon beta-1a | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
62,
24,
1613
]
],
[
[
62,
63,
600
],
[
600,
24,
1613
]
],
[
[
62,
24,
1503
],
[
1503,
24,
1613
]
],
[
[
62,
24,
1383
],
[
1383,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Lindane and Li... |
DB06589 | DB09083 | 1,250 | 880 | [
"DDInter1400",
"DDInter996"
] | Pazopanib | Ivabradine | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
1250,
25,
880
]
],
[
[
1250,
63,
480
],
[
480,
24,
880
]
],
[
[
1250,
24,
1478
],
[
1478,
24,
880
]
],
[
[
1250,
24,
159
],
[
159,
... | [
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoterol",... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor... |
DB01142 | DB09118 | 1,264 | 1,580 | [
"DDInter593",
"DDInter1711"
] | Doxepin | Stiripentol | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
1264,
24,
1580
]
],
[
[
1264,
24,
283
],
[
283,
63,
1580
]
],
[
[
1264,
24,
1532
],
[
1532,
24,
1580
]
],
[
[
1264,
63,
1219
],
[
1219... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
"... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide ... |
DB00599 | DB01168 | 682 | 1,053 | [
"DDInter1795",
"DDInter1526"
] | Thiopental | Procarbazine | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does no... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
682,
24,
1053
]
],
[
[
682,
25,
126
],
[
126,
23,
1053
]
],
[
[
682,
63,
1648
],
[
1648,
24,
1053
]
],
[
[
682,
24,
1376
],
[
1376,
... | [
[
[
"Thiopental",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Thiopental",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"Warfarin",... | Thiopental may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a ... |
DB00163 | DB00488 | 1,461 | 196 | [
"DDInter1943",
"DDInter57"
] | Vitamin E | Altretamine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Moderate | 1 | [
[
[
1461,
24,
196
]
],
[
[
1461,
23,
259
],
[
259,
63,
196
]
],
[
[
1461,
62,
1184
],
[
1184,
24,
196
]
],
[
[
1461,
24,
869
],
[
869,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Altretamine"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rilonacept"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Altretamine
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Anakinra and Anakinra may ... |
DB00662 | DB04837 | 717 | 649 | [
"DDInter1873",
"DDInter407"
] | Trimethobenzamide | Clofedanol | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
717,
24,
649
]
],
[
[
717,
24,
1376
],
[
1376,
24,
649
]
],
[
[
717,
63,
21
],
[
21,
24,
649
]
],
[
[
717,
64,
675
],
[
675,
40,... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydrami... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00580 | DB01276 | 311 | 123 | [
"DDInter1910",
"DDInter706"
] | Valdecoxib | Exenatide | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
311,
24,
123
]
],
[
[
311,
24,
1476
],
[
1476,
63,
123
]
],
[
[
311,
24,
1573
],
[
1573,
24,
123
]
],
[
[
311,
63,
1560
],
[
1560,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednis... |
DB01244 | DB11730 | 762 | 351 | [
"DDInter192",
"DDInter1588"
] | Bepridil | Ribociclib | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
762,
25,
351
]
],
[
[
762,
62,
112
],
[
112,
23,
351
]
],
[
[
762,
24,
283
],
[
283,
62,
351
]
],
[
[
762,
63,
355
],
[
355,
24,... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Bepridil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazole... | Bepridil may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratin... |
DB00402 | DB00719 | 1,407 | 1,219 | [
"DDInter685",
"DDInter149"
] | Eszopiclone | Azatadine | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1407,
24,
1219
]
],
[
[
1407,
24,
13
],
[
13,
24,
1219
]
],
[
[
1407,
24,
830
],
[
830,
1,
1219
]
],
[
[
1407,
6,
8374
],
[
8374,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine... |
DB00175 | DB06210 | 681 | 72 | [
"DDInter1509",
"DDInter631"
] | Pravastatin | Eltrombopag | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
681,
24,
72
]
],
[
[
681,
6,
3486
],
[
3486,
45,
72
]
],
[
[
681,
24,
384
],
[
384,
63,
72
]
],
[
[
681,
35,
467
],
[
467,
24,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Pravastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Pravastatin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Eltrombopag (Compound)
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Pravastatin (C... |
DB00254 | DB01324 | 964 | 178 | [
"DDInter598",
"DDInter1490"
] | Doxycycline | Polythiazide | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Minor | 0 | [
[
[
964,
23,
178
]
],
[
[
964,
23,
674
],
[
674,
40,
178
]
],
[
[
964,
1,
1669
],
[
1669,
23,
178
]
],
[
[
964,
40,
1620
],
[
1620,
... | [
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Polythiazide"
]
],
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trichlormethiazide"
],
... | Doxycycline may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Doxycycline (Compound) resembles Minocycline (Compound) and Minocycline may cause a minor interaction that can limit clinical effects when take... |
DB01284 | DB06203 | 1,042 | 1,002 | [
"DDInter1782",
"DDInter51"
] | Tetracosactide | Alogliptin | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
1042,
24,
1002
]
],
[
[
1042,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
1042,
63,
504
],
[
504,
24,
1002
]
],
[
[
1042,
62,
1674
],
[
1674... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide may cause a mod... |
DB00619 | DB01215 | 1,419 | 1,418 | [
"DDInter909",
"DDInter677"
] | Imatinib | Estazolam | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
1419,
24,
1418
]
],
[
[
1419,
63,
523
],
[
523,
1,
1418
]
],
[
[
1419,
24,
1216
],
[
1216,
40,
1418
]
],
[
[
1419,
63,
87
],
[
87,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
Imatin... |
DB00694 | DB01211 | 51 | 609 | [
"DDInter485",
"DDInter393"
] | Daunorubicin | Clarithromycin | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
51,
24,
609
]
],
[
[
51,
63,
1570
],
[
1570,
24,
609
]
],
[
[
51,
6,
4973
],
[
4973,
45,
609
]
],
[
[
51,
18,
4904
],
[
4904,
46... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
]... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Daunorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Daun... |
DB00857 | DB01577 | 1,387 | 1,529 | [
"DDInter1768",
"DDInter1161"
] | Terbinafine | Metamfetamine | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
1387,
24,
1529
]
],
[
[
1387,
63,
80
],
[
80,
40,
1529
]
],
[
[
1387,
24,
1039
],
[
1039,
25,
1529
]
],
[
[
1387,
6,
12523
],
[
12523,... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
... | Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Metamfetamine (Compound)
Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may lead to a major life t... |
DB00283 | DB04946 | 701 | 924 | [
"DDInter395",
"DDInter907"
] | Clemastine | Iloperidone | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
701,
24,
924
]
],
[
[
701,
24,
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],
[
1664,
1,
924
]
],
[
[
701,
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519
],
[
519,
40,
924
]
],
[
[
701,
6,
10104
],
[
10104,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperidone (Co... |
DB00207 | DB06616 | 1,570 | 594 | [
"DDInter157",
"DDInter224"
] | Azithromycin | Bosutinib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1570,
24,
594
]
],
[
[
1570,
6,
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],
[
8374,
45,
594
]
],
[
[
1570,
21,
28709
],
[
28709,
60,
594
]
],
[
[
1570,
23,
112
],
[
112,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Azithromycin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Bosutinib (Compound)
Azithromycin may cause a minor interaction that can limit clinical effects when taken with... |
DB01229 | DB11828 | 973 | 1,406 | [
"DDInter1378",
"DDInter1281"
] | Paclitaxel (protein-bound) | Neratinib | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
973,
24,
1406
]
],
[
[
973,
24,
392
],
[
392,
24,
1406
]
],
[
[
973,
25,
1510
],
[
1510,
24,
1406
]
],
[
[
973,
63,
134
],
[
134,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Paclitaxel may... |
DB00060 | DB00624 | 912 | 1,561 | [
"DDInter947",
"DDInter1775"
] | Interferon beta-1a | Testosterone | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Moderate | 1 | [
[
[
912,
24,
1561
]
],
[
[
912,
24,
155
],
[
155,
1,
1561
]
],
[
[
912,
24,
1026
],
[
1026,
40,
1561
]
],
[
[
912,
24,
322
],
[
322,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymes... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Testosterone (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxandrolone (Compound) re... |
DB00444 | DB14443 | 63 | 987 | [
"DDInter1765",
"DDInter1931"
] | Teniposide | Vibrio cholerae CVD 103-HgR strain live antigen | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
63,
24,
987
]
],
[
[
63,
24,
1480
],
[
1480,
24,
987
]
],
[
[
63,
64,
581
],
[
581,
24,
987
]
],
[
[
63,
25,
1510
],
[
1510,
24,... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Teniposide may lead to a major life threatening interaction when taken with Inf... |
DB06691 | DB09128 | 849 | 1,241 | [
"DDInter1155",
"DDInter231"
] | Mepyramine | Brexpiprazole | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
849,
24,
1241
]
],
[
[
849,
24,
407
],
[
407,
63,
1241
]
],
[
[
849,
63,
543
],
[
543,
24,
1241
]
],
[
[
849,
74,
100
],
[
100,
... | [
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
... | Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide ma... |
DB00581 | DB04948 | 355 | 1,084 | [
"DDInter1018",
"DDInter1083"
] | Lactulose | Lofexidine | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
355,
24,
1084
]
],
[
[
355,
63,
618
],
[
618,
24,
1084
]
],
[
[
355,
24,
774
],
[
774,
63,
1084
]
],
[
[
355,
24,
688
],
[
688,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abarelix"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Abarelix and Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degarelix may... |
DB00700 | DB00945 | 312 | 1,479 | [
"DDInter656",
"DDInter20"
] | Eplerenone | Acetylsalicylic acid | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
312,
24,
1479
]
],
[
[
312,
5,
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],
[
11576,
44,
1479
]
],
[
[
312,
21,
29102
],
[
29102,
60,
1479
]
],
[
[
312,
40,
443
],
[
443,... | [
[
[
"Eplerenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Eplerenone",
"{u} (Compound) treats {v} (Disease)",
"coronary artery disease"
],
[
"coronary artery disease"... | Eplerenone (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Acetylsalicylic acid (Compound)
Eplerenone (Compound) causes Kidney function abnormal (Side Effect) and Kidney function abnormal (Side Effect) is caused by Acetylsalicylic acid (Compound)
Eplerenone (Compo... |
DB11986 | DB14575 | 484 | 733 | [
"DDInter648",
"DDInter674"
] | Entrectinib | Eslicarbazepine | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
484,
24,
733
]
],
[
[
484,
63,
1101
],
[
1101,
23,
733
]
],
[
[
484,
63,
1264
],
[
1264,
24,
733
]
],
[
[
484,
62,
222
],
[
222,
... | [
[
[
"Entrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Entrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxe... |
DB01175 | DB09075 | 318 | 498 | [
"DDInter672",
"DDInter621"
] | Escitalopram | Edoxaban | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
318,
24,
498
]
],
[
[
318,
64,
222
],
[
222,
24,
498
]
],
[
[
318,
24,
1017
],
[
1017,
63,
498
]
],
[
[
318,
25,
1039
],
[
1039,
... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutra... | Escitalopram may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may ca... |
DB00204 | DB12141 | 228 | 971 | [
"DDInter580",
"DDInter817"
] | Dofetilide | Gilteritinib | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
228,
25,
971
]
],
[
[
228,
23,
112
],
[
112,
23,
971
]
],
[
[
228,
25,
485
],
[
485,
24,
971
]
],
[
[
228,
25,
823
],
[
823,
63,... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Dofetilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Dofetilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Dofetilide may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may ... |
DB00331 | DB00827 | 1,645 | 646 | [
"DDInter1164",
"DDInter383"
] | Metformin | Cinoxacin | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Moderate | 1 | [
[
[
1645,
24,
646
]
],
[
[
1645,
21,
28691
],
[
28691,
60,
646
]
],
[
[
1645,
24,
417
],
[
417,
24,
646
]
],
[
[
1645,
62,
1647
],
[
1647,... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cinoxacin"
]
],
[
[
"Metformin",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is cause... | Metformin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Cinoxacin (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Cinoxaci... |
DB05812 | DB09472 | 1,374 | 1,383 | [
"DDInter8",
"DDInter1693"
] | Abiraterone | Sodium sulfate | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1374,
24,
1383
]
],
[
[
1374,
63,
678
],
[
678,
24,
1383
]
],
[
[
1374,
24,
1342
],
[
1342,
24,
1383
]
],
[
[
1374,
24,
1612
],
[
1612... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxamniquine"
],
... | Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Oxamniquine and Oxamniquine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin an... |
DB00773 | DB08820 | 896 | 1,478 | [
"DDInter702",
"DDInter997"
] | Etoposide | Ivacaftor | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
896,
24,
1478
]
],
[
[
896,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
896,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
896,
62,
307
],
[
307,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Etoposide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Etoposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Etoposide (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Etoposide may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafini... |
DB11986 | DB13074 | 484 | 877 | [
"DDInter648",
"DDInter1110"
] | Entrectinib | Macimorelin | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
484,
25,
877
]
],
[
[
484,
62,
112
],
[
112,
23,
877
]
],
[
[
484,
63,
1320
],
[
1320,
24,
877
]
],
[
[
484,
64,
651
],
[
651,
2... | [
[
[
"Entrectinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Entrectinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Entrectinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Ela... |
DB01041 | DB04845 | 770 | 309 | [
"DDInter1789",
"DDInter1001"
] | Thalidomide | Ixabepilone | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
770,
24,
309
]
],
[
[
770,
21,
28736
],
[
28736,
60,
309
]
],
[
[
770,
25,
60
],
[
60,
23,
309
]
],
[
[
770,
63,
1419
],
[
1419,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Thalidomide",
"{u} (Compound) causes {v} (Side Effect)",
"Dehydration"
],
[
"Dehydration",
"{u} (Side Effect) ... | Thalidomide (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone (Compound)
Thalidomide may lead to a major life threatening interaction when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Ixabepilone
T... |
DB00434 | DB00454 | 13 | 1,349 | [
"DDInter459",
"DDInter1150"
] | Cyproheptadine | Meperidine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Moderate | 1 | [
[
[
13,
24,
1349
]
],
[
[
13,
24,
901
],
[
901,
1,
1349
]
],
[
[
13,
6,
7390
],
[
7390,
45,
1349
]
],
[
[
13,
21,
28929
],
[
28929,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meperidine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Meperidine (Compound)
Cyproheptadine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Meperidine (Compound)
Cyproheptadine (Compound) causes Confusional state (Side... |
DB06595 | DB12245 | 1,491 | 823 | [
"DDInter1214",
"DDInter1863"
] | Midostaurin | Triclabendazole | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1491,
24,
823
]
],
[
[
1491,
62,
1247
],
[
1247,
23,
823
]
],
[
[
1491,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1491,
63,
1010
],
[
1010,... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Midostaurin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
... | Midostaurin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Fostem... |
DB00531 | DB06372 | 450 | 259 | [
"DDInter456",
"DDInter1594"
] | Cyclophosphamide | Rilonacept | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
450,
24,
259
]
],
[
[
450,
63,
1461
],
[
1461,
23,
259
]
],
[
[
450,
24,
1619
],
[
1619,
63,
259
]
],
[
[
450,
24,
37
],
[
37,
2... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and... |
DB00960 | DB09481 | 887 | 460 | [
"DDInter1471",
"DDInter1113"
] | Pindolol | Magnesium carbonate | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
887,
23,
460
]
],
[
[
887,
24,
401
],
[
401,
23,
460
]
],
[
[
887,
63,
999
],
[
999,
23,
460
]
],
[
[
887,
1,
699
],
[
699,
23,
... | [
[
[
"Pindolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazi... |
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