drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00372 | DB00985 | 999 | 1,443 | [
"DDInter1793",
"DDInter562"
] | Thiethylperazine | Dimenhydrinate | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | Moderate | 1 | [
[
[
999,
24,
1443
]
],
[
[
999,
24,
1376
],
[
1376,
63,
1443
]
],
[
[
999,
63,
357
],
[
357,
1,
1443
]
],
[
[
999,
24,
358
],
[
358,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimenhydrinate"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydra... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dimenhydrinate
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01285 | DB11640 | 708 | 1,267 | [
"DDInter445",
"DDInter64"
] | Corticotropin | Amifampridine | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
708,
24,
1267
]
],
[
[
708,
63,
61
],
[
61,
24,
1267
]
],
[
[
708,
24,
1662
],
[
1662,
24,
1267
]
],
[
[
708,
64,
593
],
[
593,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edrophonium"
]... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium and Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfur... |
DB00023 | DB08860 | 305 | 788 | [
"DDInter127",
"DDInter1479"
] | Asparaginase Escherichia coli | Pitavastatin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
305,
24,
788
]
],
[
[
305,
24,
671
],
[
671,
1,
788
]
],
[
[
305,
24,
700
],
[
700,
40,
788
]
],
[
[
305,
24,
126
],
[
126,
23,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastat... |
DB06212 | DB11978 | 165 | 124 | [
"DDInter1833",
"DDInter822"
] | Tolvaptan | Glasdegib | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
165,
24,
124
]
],
[
[
165,
23,
1135
],
[
1135,
23,
124
]
],
[
[
165,
23,
466
],
[
466,
62,
124
]
],
[
[
165,
63,
79
],
[
79,
24,... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Tolvaptan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"N... | Tolvaptan may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Tolvaptan may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide ma... |
DB00612 | DB06663 | 1,121 | 1,154 | [
"DDInter216",
"DDInter1398"
] | Bisoprolol | Pasireotide | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
1121,
24,
1154
]
],
[
[
1121,
63,
966
],
[
966,
40,
1154
]
],
[
[
1121,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1121,
1,
88
],
[
88,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Bisoprolol (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Bisoprolol (Compound) resembles ... |
DB00333 | DB12245 | 576 | 823 | [
"DDInter1166",
"DDInter1863"
] | Methadone | Triclabendazole | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Major | 2 | [
[
[
576,
25,
823
]
],
[
[
576,
23,
112
],
[
112,
23,
823
]
],
[
[
576,
25,
1010
],
[
1010,
24,
823
]
],
[
[
576,
24,
28
],
[
28,
24,... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triclabendazole"
]
],
[
[
"Methadone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Methadone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Methadone may lead to a major life threatening interaction when taken with Mefloquine and Mefloquine may c... |
DB00465 | DB13074 | 886 | 877 | [
"DDInter1010",
"DDInter1110"
] | Ketorolac | Macimorelin | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
886,
24,
877
]
],
[
[
886,
25,
1479
],
[
1479,
24,
877
]
],
[
[
886,
24,
1662
],
[
1662,
24,
877
]
],
[
[
886,
1,
24
],
[
24,
24... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetylsalicylic acid"
],
[
"A... | Ketorolac may lead to a major life threatening interaction when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid... |
DB06273 | DB08904 | 980 | 375 | [
"DDInter1824",
"DDInter342"
] | Tocilizumab | Certolizumab pegol | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
980,
25,
375
]
],
[
[
980,
62,
1461
],
[
1461,
23,
375
]
],
[
[
980,
23,
1193
],
[
1193,
62,
375
]
],
[
[
980,
63,
231
],
[
231,
... | [
[
[
"Tocilizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Tocilizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vit... | Tocilizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Tocilizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and ... |
DB00795 | DB09156 | 50 | 777 | [
"DDInter1725",
"DDInter964"
] | Sulfasalazine | Iopromide | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Major | 2 | [
[
[
50,
25,
777
]
],
[
[
50,
24,
1074
],
[
1074,
63,
777
]
],
[
[
50,
63,
372
],
[
372,
25,
777
]
],
[
[
50,
24,
1171
],
[
1171,
25,... | [
[
[
"Sulfasalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iopromide"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
],
[
"Iod... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine ... |
DB00877 | DB09045 | 629 | 52 | [
"DDInter1678",
"DDInter607"
] | Sirolimus | Dulaglutide | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
629,
24,
52
]
],
[
[
629,
24,
170
],
[
170,
23,
52
]
],
[
[
629,
25,
609
],
[
609,
24,
52
]
],
[
[
629,
63,
989
],
[
989,
24,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Sirolimus may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may... |
DB00586 | DB11793 | 1,512 | 738 | [
"DDInter537",
"DDInter1297"
] | Diclofenac | Niraparib | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1512,
24,
738
]
],
[
[
1512,
25,
1213
],
[
1213,
24,
738
]
],
[
[
1512,
24,
1033
],
[
1033,
63,
738
]
],
[
[
1512,
64,
663
],
[
663,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Diclofenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
... | Diclofenac may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a mod... |
DB01056 | DB11988 | 571 | 270 | [
"DDInter1823",
"DDInter1321"
] | Tocainide | Ocrelizumab | An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
571,
24,
270
]
],
[
[
571,
24,
4
],
[
4,
24,
270
]
],
[
[
571,
63,
599
],
[
599,
24,
270
]
],
[
[
571,
24,
976
],
[
976,
25,
... | [
[
[
"Tocainide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Tocainide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
... | Tocainide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Tocainide may cause a moderate interaction that could exacerbate diseases when tak... |
DB00712 | DB01136 | 1,274 | 772 | [
"DDInter763",
"DDInter305"
] | Flurbiprofen | Carvedilol | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
1274,
24,
772
]
],
[
[
1274,
6,
6017
],
[
6017,
45,
772
]
],
[
[
1274,
21,
28997
],
[
28997,
60,
772
]
],
[
[
1274,
24,
578
],
[
578,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compoun... | Flurbiprofen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Carvedilol (Compound)
Flurbiprofen (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Carvedilol (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when ta... |
DB00500 | DB00682 | 24 | 126 | [
"DDInter1831",
"DDInter1951"
] | Tolmetin | Warfarin | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Major | 2 | [
[
[
24,
25,
126
]
],
[
[
24,
25,
663
],
[
663,
23,
126
]
],
[
[
24,
24,
477
],
[
477,
62,
126
]
],
[
[
24,
1,
1062
],
[
1062,
23,
... | [
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
]
],
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrexate"
],
[
"Methotrexate",
"{u} may... | Tolmetin may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Warfarin
Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a mi... |
DB03904 | DB09038 | 1,574 | 1,450 | [
"DDInter1903",
"DDInter636"
] | Urea | Empagliflozin | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1574,
24,
1450
]
],
[
[
1574,
24,
1455
],
[
1455,
63,
1450
]
],
[
[
1574,
23,
1399
],
[
1399,
63,
1450
]
],
[
[
1574,
63,
222
],
[
222... | [
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
],
[
"Ni... | Urea may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid and Nitrous acid may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Urea may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate and Lithiu... |
DB00637 | DB14568 | 1,557 | 982 | [
"DDInter128",
"DDInter1000"
] | Astemizole | Ivosidenib | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1557,
25,
982
]
],
[
[
1557,
23,
112
],
[
112,
23,
982
]
],
[
[
1557,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1557,
24,
543
],
[
543,
... | [
[
[
"Astemizole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexa... |
DB01041 | DB11363 | 770 | 1,276 | [
"DDInter1789",
"DDInter39"
] | Thalidomide | Alectinib | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
770,
24,
1276
]
],
[
[
770,
24,
819
],
[
819,
24,
1276
]
],
[
[
770,
63,
775
],
[
775,
24,
1276
]
],
[
[
770,
64,
305
],
[
305,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Isoflurophate and Is... |
DB00502 | DB09078 | 1,300 | 1,228 | [
"DDInter853",
"DDInter1036"
] | Haloperidol | Lenvatinib | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1300,
25,
1228
]
],
[
[
1300,
23,
112
],
[
112,
23,
1228
]
],
[
[
1300,
25,
609
],
[
609,
24,
1228
]
],
[
[
1300,
24,
770
],
[
770,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Haloperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Haloperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Haloperidol may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromyci... |
DB08889 | DB08913 | 350 | 1,186 | [
"DDInter299",
"DDInter1561"
] | Carfilzomib | Radium Ra 223 dichloride | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
350,
24,
1186
]
],
[
[
350,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
350,
63,
134
],
[
134,
24,
1186
]
],
[
[
350,
24,
1362
],
[
1362,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Carfilzomib",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effec... | Carfilzomib (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01030 | DB01206 | 869 | 37 | [
"DDInter1835",
"DDInter1086"
] | Topotecan | Lomustine | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
869,
24,
37
]
],
[
[
869,
6,
8374
],
[
8374,
45,
37
]
],
[
[
869,
21,
28722
],
[
28722,
60,
37
]
],
[
[
869,
62,
1176
],
[
1176,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Topotecan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Topotecan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomustine (Compound)
Topotecan (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine (Compound)
Topotecan may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin ma... |
DB05239 | DB06168 | 866 | 1,531 | [
"DDInter425",
"DDInter281"
] | Cobimetinib | Canakinumab | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
866,
24,
1531
]
],
[
[
866,
24,
1270
],
[
1270,
63,
1531
]
],
[
[
866,
63,
1213
],
[
1213,
24,
1531
]
],
[
[
866,
64,
697
],
[
697,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified prot... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Cobimetinib may cause a moderate interaction that coul... |
DB00283 | DB09118 | 701 | 1,580 | [
"DDInter395",
"DDInter1711"
] | Clemastine | Stiripentol | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
701,
24,
1580
]
],
[
[
701,
24,
1532
],
[
1532,
24,
1580
]
],
[
[
701,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
701,
35,
1594
],
[
1594,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pe... |
DB00220 | DB00836 | 798 | 543 | [
"DDInter1276",
"DDInter1088"
] | Nelfinavir | Loperamide | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Major | 2 | [
[
[
798,
25,
543
]
],
[
[
798,
24,
888
],
[
888,
24,
543
]
],
[
[
798,
6,
8374
],
[
8374,
45,
543
]
],
[
[
798,
18,
5833
],
[
5833,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Loperamide"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[
"Tamoxifen",... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Loperamide (Compound)
Nelfinavir (Compound... |
DB00649 | DB04845 | 231 | 309 | [
"DDInter1710",
"DDInter1001"
] | Stavudine | Ixabepilone | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
231,
24,
309
]
],
[
[
231,
21,
28987
],
[
28987,
60,
309
]
],
[
[
231,
40,
139
],
[
139,
24,
309
]
],
[
[
231,
24,
1434
],
[
1434,
... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Stavudine",
"{u} (Compound) causes {v} (Side Effect)",
"Chills"
],
[
"Chills",
"{u} (Side Effect) is caused by {... | Stavudine (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Stavudine (Compound) resembles Zidovudine (Compound) and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone
Stavudine may cause a moderate interaction that co... |
DB00282 | DB00626 | 641 | 1,441 | [
"DDInter1383",
"DDInter161"
] | Pamidronic acid | Bacitracin | Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic ... | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Moderate | 1 | [
[
[
641,
24,
1441
]
],
[
[
641,
24,
1481
],
[
1481,
1,
1441
]
],
[
[
641,
21,
28719
],
[
28719,
60,
1441
]
],
[
[
641,
24,
1555
],
[
1555,... | [
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacitracin"
]
],
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polymyxin B"
... | Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Bacitracin (Compound)
Pamidronic acid (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Bacitracin (Compound)
Pamidronic acid may cause a moderate inter... |
DB00282 | DB00526 | 641 | 1,555 | [
"DDInter1383",
"DDInter1355"
] | Pamidronic acid | Oxaliplatin | Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic ... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
641,
24,
1555
]
],
[
[
641,
1,
1199
],
[
1199,
63,
1555
]
],
[
[
641,
24,
485
],
[
485,
63,
1555
]
],
[
[
641,
1,
963
],
[
963,
... | [
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Pamidronic acid",
"{u} (Compound) resembles {v} (Compound)",
"Ibandronate"
],
[
"Ibandronate",
"{u} may ca... | Pamidronic acid (Compound) resembles Ibandronate (Compound) and Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interac... |
DB00962 | DB09098 | 1,639 | 98 | [
"DDInter1957",
"DDInter1700"
] | Zaleplon | Somatrem | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1639,
24,
98
]
],
[
[
1639,
24,
159
],
[
159,
63,
98
]
],
[
[
1639,
24,
222
],
[
222,
24,
98
]
],
[
[
1639,
63,
629
],
[
629,
24... | [
[
[
"Zaleplon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Zaleplon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibut... |
DB01177 | DB11915 | 77 | 1,293 | [
"DDInter904",
"DDInter1909"
] | Idarubicin | Valbenazine | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
77,
24,
1293
]
],
[
[
77,
62,
112
],
[
112,
23,
1293
]
],
[
[
77,
63,
521
],
[
521,
24,
1293
]
],
[
[
77,
24,
392
],
[
392,
24,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Idarubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Idarubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Gose... |
DB01064 | DB09330 | 1,148 | 985 | [
"DDInter987",
"DDInter1352"
] | Isoprenaline | Osimertinib | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1148,
25,
985
]
],
[
[
1148,
63,
480
],
[
480,
24,
985
]
],
[
[
1148,
24,
1032
],
[
1032,
63,
985
]
],
[
[
1148,
23,
1220
],
[
1220,
... | [
[
[
"Isoprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formo... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol a... |
DB01592 | DB08917 | 1,596 | 1,608 | [
"DDInter975",
"DDInter723"
] | Iron | Ferric carboxymaltose | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013. | Moderate | 1 | [
[
[
1596,
24,
1608
]
],
[
[
1596,
63,
597
],
[
597,
24,
1608
]
],
[
[
1596,
25,
1575
],
[
1575,
25,
1608
]
],
[
[
1596,
63,
597
],
[
597,
... | [
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferric carboxymaltose"
]
],
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
... | Iron may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Ferric carboxymaltose
Iron may lead to a major life threatening interaction when taken with Dimercaprol and Dimercaprol... |
DB00059 | DB00987 | 1,560 | 1,224 | [
"DDInter1404",
"DDInter460"
] | Pegaspargase | Cytarabine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Moderate | 1 | [
[
[
1560,
24,
1224
]
],
[
[
1560,
24,
1176
],
[
1176,
23,
1224
]
],
[
[
1560,
24,
322
],
[
322,
24,
1224
]
],
[
[
1560,
24,
987
],
[
987,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moxifloxacin"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Cytarabine
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and ... |
DB01193 | DB01309 | 819 | 1,254 | [
"DDInter12",
"DDInter933"
] | Acebutolol | Insulin glulisine | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
819,
24,
1254
]
],
[
[
819,
63,
167
],
[
167,
24,
1254
]
],
[
[
819,
24,
1220
],
[
1220,
24,
1254
]
],
[
[
819,
40,
887
],
[
887,
... | [
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
... | Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Dexame... |
DB00850 | DB09104 | 1,630 | 286 | [
"DDInter1432",
"DDInter1118"
] | Perphenazine | Magnesium hydroxide | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1630,
24,
286
]
],
[
[
1630,
35,
820
],
[
820,
23,
286
]
],
[
[
1630,
1,
146
],
[
146,
23,
286
]
],
[
[
1630,
63,
999
],
[
999,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Perphenazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases... | Perphenazine (Compound) resembles Alimemazine (Compound) and Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Perphenazine (Compound) resembles Propio... |
DB11703 | DB11718 | 405 | 927 | [
"DDInter9",
"DDInter640"
] | Acalabrutinib | Encorafenib | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
405,
25,
927
]
],
[
[
405,
63,
536
],
[
536,
24,
927
]
],
[
[
405,
64,
998
],
[
998,
24,
927
]
],
[
[
405,
24,
484
],
[
484,
63,... | [
[
[
"Acalabrutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Acalabrutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
[
"S... | Acalabrutinib may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Acalabrutinib may lead to a major life threatening interaction when taken with Phenylbutazone and Phenyl... |
DB01168 | DB06237 | 1,053 | 438 | [
"DDInter1526",
"DDInter141"
] | Procarbazine | Avanafil | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual ... | Moderate | 1 | [
[
[
1053,
24,
438
]
],
[
[
1053,
21,
29118
],
[
29118,
60,
438
]
],
[
[
1053,
63,
1214
],
[
1214,
24,
438
]
],
[
[
1053,
24,
885
],
[
885,... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avanafil"
]
],
[
[
"Procarbazine",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect) i... | Procarbazine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Avanafil (Compound)
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Ava... |
DB01075 | DB11823 | 1,376 | 858 | [
"DDInter569",
"DDInter673"
] | Diphenhydramine | Esketamine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Moderate | 1 | [
[
[
1376,
24,
858
]
],
[
[
1376,
35,
272
],
[
272,
24,
858
]
],
[
[
1376,
63,
506
],
[
506,
24,
858
]
],
[
[
1376,
24,
849
],
[
849,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esketamine"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases wh... | Diphenhydramine (Compound) resembles Chlorpheniramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Diphenhydramine may cause ... |
DB00331 | DB00364 | 1,645 | 417 | [
"DDInter1164",
"DDInter1717"
] | Metformin | Sucralfate | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a _cytoprotective agent_, protec... | Moderate | 1 | [
[
[
1645,
24,
417
]
],
[
[
1645,
21,
28845
],
[
28845,
60,
417
]
],
[
[
1645,
24,
1512
],
[
1512,
62,
417
]
],
[
[
1645,
63,
1152
],
[
115... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
]
],
[
[
"Metformin",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema"
],
[
"Oedema",
"{u} (Side Effect) is caused by {v... | Metformin (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Sucralfate (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Metfor... |
DB00872 | DB11718 | 1,080 | 927 | [
"DDInter438",
"DDInter640"
] | Conivaptan | Encorafenib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
1080,
25,
927
]
],
[
[
1080,
24,
659
],
[
659,
24,
927
]
],
[
[
1080,
63,
1324
],
[
1324,
24,
927
]
],
[
[
1080,
1,
165
],
[
165,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[
"Vilantero... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Tro... |
DB00013 | DB04932 | 1,255 | 1,564 | [
"DDInter1905",
"DDInter491"
] | Urokinase | Defibrotide | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Major | 2 | [
[
[
1255,
25,
1564
]
],
[
[
1255,
23,
297
],
[
297,
62,
1564
]
],
[
[
1255,
24,
914
],
[
914,
24,
1564
]
],
[
[
1255,
24,
41
],
[
41,
... | [
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Defibrotide"
]
],
[
[
"Urokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u}... | Urokinase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Defibrotide
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause ... |
DB00747 | DB01075 | 1,442 | 1,376 | [
"DDInter1647",
"DDInter569"
] | Scopolamine | Diphenhydramine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1442,
24,
1376
]
],
[
[
1442,
63,
128
],
[
128,
24,
1376
]
],
[
[
1442,
24,
832
],
[
832,
24,
1376
]
],
[
[
1442,
64,
675
],
[
675,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB11095 | DB11703 | 235 | 405 | [
"DDInter505",
"DDInter9"
] | Desirudin | Acalabrutinib | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
235,
25,
405
]
],
[
[
235,
63,
643
],
[
643,
24,
405
]
],
[
[
235,
24,
738
],
[
738,
63,
405
]
],
[
[
235,
64,
1220
],
[
1220,
2... | [
[
[
"Desirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Desirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
],
[
"Desve... | Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib an... |
DB00443 | DB00465 | 251 | 886 | [
"DDInter195",
"DDInter1010"
] | Betamethasone | Ketorolac | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Moderate | 1 | [
[
[
251,
24,
886
]
],
[
[
251,
24,
24
],
[
24,
40,
886
]
],
[
[
251,
6,
7720
],
[
7720,
45,
886
]
],
[
[
251,
7,
20038
],
[
20038,
4... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketorolac"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolmetin"
],
[... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin and Tolmetin (Compound) resembles Ketorolac (Compound)
Betamethasone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Ketorolac (Compound)
Betamethasone (Compound) upregulates FAIM (Gene) and FAIM (Gene) is ... |
DB00197 | DB00820 | 1,324 | 402 | [
"DDInter1881",
"DDInter1736"
] | Troglitazone | Tadalafil | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Moderate | 1 | [
[
[
1324,
24,
402
]
],
[
[
1324,
24,
159
],
[
159,
63,
402
]
],
[
[
1324,
24,
1419
],
[
1419,
24,
402
]
],
[
[
1324,
23,
1101
],
[
1101,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tadalafil"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Tadalafil
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and... |
DB00059 | DB00584 | 1,560 | 610 | [
"DDInter1404",
"DDInter638"
] | Pegaspargase | Enalapril | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Moderate | 1 | [
[
[
1560,
24,
610
]
],
[
[
1560,
24,
743
],
[
743,
1,
610
]
],
[
[
1560,
24,
954
],
[
954,
40,
610
]
],
[
[
1560,
24,
1144
],
[
1144,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril (Compound) resembles Enalapril (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Enalapril (Compound)
... |
DB00095 | DB05679 | 66 | 1,683 | [
"DDInter623",
"DDInter1907"
] | Efalizumab | Ustekinumab | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
66,
24,
1683
]
],
[
[
66,
23,
1461
],
[
1461,
23,
1683
]
],
[
[
66,
23,
1193
],
[
1193,
62,
1683
]
],
[
[
66,
24,
1042
],
[
1042,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluc... |
DB04575 | DB13928 | 35 | 1,385 | [
"DDInter1555",
"DDInter1660"
] | Quinestrol | Semaglutide | The 3-cyclopentyl ether of ethinyl estradiol. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
35,
24,
1385
]
],
[
[
35,
63,
891
],
[
891,
24,
1385
]
],
[
[
35,
24,
1476
],
[
1476,
24,
1385
]
],
[
[
35,
40,
559
],
[
559,
24... | [
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
[... | Quinestrol may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Quinestrol may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and B... |
DB00333 | DB00938 | 576 | 455 | [
"DDInter1166",
"DDInter1635"
] | Methadone | Salmeterol | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
576,
24,
455
]
],
[
[
576,
24,
688
],
[
688,
63,
455
]
],
[
[
576,
6,
6799
],
[
6799,
45,
455
]
],
[
[
576,
21,
28722
],
[
28722,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Methadone (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Salmeterol (Compound)
Methadone (Compound)... |
DB09065 | DB12332 | 760 | 1,619 | [
"DDInter424",
"DDInter1626"
] | Cobicistat | Rucaparib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
760,
24,
1619
]
],
[
[
760,
63,
307
],
[
307,
23,
1619
]
],
[
[
760,
62,
271
],
[
271,
23,
1619
]
],
[
[
760,
64,
1135
],
[
1135,
... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Cobicistat may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron ma... |
DB01097 | DB08886 | 1,377 | 637 | [
"DDInter1033",
"DDInter126"
] | Leflunomide | Asparaginase Erwinia chrysanthemi | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Major | 2 | [
[
[
1377,
25,
637
]
],
[
[
1377,
64,
640
],
[
640,
24,
637
]
],
[
[
1377,
25,
392
],
[
392,
24,
637
]
],
[
[
1377,
25,
250
],
[
250,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acitretin"
],
[
"A... | Leflunomide may lead to a major life threatening interaction when taken with Acitretin and Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Leflunomide may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may ... |
DB00398 | DB00564 | 79 | 1,236 | [
"DDInter1702",
"DDInter293"
] | Sorafenib | Carbamazepine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
79,
24,
1236
]
],
[
[
79,
24,
307
],
[
307,
1,
1236
]
],
[
[
79,
63,
362
],
[
362,
1,
1236
]
],
[
[
79,
24,
820
],
[
820,
63,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Carbamazepine (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Compound)
... |
DB01118 | DB14568 | 33 | 982 | [
"DDInter76",
"DDInter1000"
] | Amiodarone | Ivosidenib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
33,
25,
982
]
],
[
[
33,
63,
112
],
[
112,
23,
982
]
],
[
[
33,
24,
976
],
[
976,
24,
982
]
],
[
[
33,
64,
543
],
[
543,
24,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and T... |
DB00777 | DB01261 | 146 | 170 | [
"DDInter1537",
"DDInter1679"
] | Propiomazine | Sitagliptin | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
146,
24,
170
]
],
[
[
146,
24,
52
],
[
52,
62,
170
]
],
[
[
146,
63,
1179
],
[
1179,
24,
170
]
],
[
[
146,
40,
216
],
[
216,
24,... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
],
... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro a... |
DB00361 | DB01208 | 134 | 945 | [
"DDInter1939",
"DDInter1705"
] | Vinorelbine | Sparfloxacin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
134,
23,
945
]
],
[
[
134,
23,
739
],
[
739,
1,
945
]
],
[
[
134,
62,
1176
],
[
1176,
1,
945
]
],
[
[
134,
6,
4973
],
[
4973,
45... | [
[
[
"Vinorelbine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Vinorelbine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (... |
DB00065 | DB14444 | 581 | 151 | [
"DDInter923",
"DDInter924"
] | Infliximab | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
581,
24,
151
]
],
[
[
581,
24,
66
],
[
66,
24,
151
]
],
[
[
581,
25,
134
],
[
134,
24,
151
]
],
[
[
581,
64,
305
],
[
305,
24,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could e... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Infliximab may lead to a major life t... |
DB00366 | DB00810 | 1,594 | 456 | [
"DDInter600",
"DDInter211"
] | Doxylamine | Biperiden | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Moderate | 1 | [
[
[
1594,
24,
456
]
],
[
[
1594,
24,
1105
],
[
1105,
40,
456
]
],
[
[
1594,
6,
7992
],
[
7992,
45,
456
]
],
[
[
1594,
18,
10375
],
[
10375... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Biperiden"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
],
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl (Compound) resembles Biperiden (Compound)
Doxylamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Biperiden (Compound)
Doxylamine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1... |
DB00804 | DB00934 | 1,507 | 413 | [
"DDInter543",
"DDInter1124"
] | Dicyclomine | Maprotiline | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
1507,
24,
413
]
],
[
[
1507,
63,
1302
],
[
1302,
40,
413
]
],
[
[
1507,
6,
7992
],
[
7992,
45,
413
]
],
[
[
1507,
21,
28741
],
[
28741... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Dicyclomine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Maprotiline (Compound)
Dicyclomine (Compound) causes Agitation (Side Effect) and ... |
DB00352 | DB00627 | 482 | 265 | [
"DDInter1814",
"DDInter1286"
] | Tioguanine | Niacin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Moderate | 1 | [
[
[
482,
24,
265
]
],
[
[
482,
21,
28722
],
[
28722,
60,
265
]
],
[
[
482,
63,
1647
],
[
1647,
24,
265
]
],
[
[
482,
24,
322
],
[
322,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niacin"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} ... | Tioguanine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Niacin (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Niacin
Tioguanine may... |
DB01177 | DB01206 | 77 | 37 | [
"DDInter904",
"DDInter1086"
] | Idarubicin | Lomustine | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
77,
24,
37
]
],
[
[
77,
5,
11555
],
[
11555,
44,
37
]
],
[
[
77,
6,
12523
],
[
12523,
45,
37
]
],
[
[
77,
21,
28722
],
[
28722,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Idarubicin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Idarubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Idarubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Lomustine (Compound)
Idarubicin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine (Co... |
DB01010 | DB11640 | 61 | 1,267 | [
"DDInter622",
"DDInter64"
] | Edrophonium | Amifampridine | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
61,
24,
1267
]
],
[
[
61,
24,
1220
],
[
1220,
24,
1267
]
],
[
[
61,
63,
1486
],
[
1486,
24,
1267
]
],
[
[
61,
24,
1019
],
[
1019,
... | [
[
[
"Edrophonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Edrophonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Methylpred... |
DB00570 | DB01764 | 147 | 805 | [
"DDInter1936",
"DDInter469"
] | Vinblastine | Dalfopristin | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Moderate | 1 | [
[
[
147,
24,
805
]
],
[
[
147,
6,
8374
],
[
8374,
45,
805
]
],
[
[
147,
63,
1101
],
[
1101,
23,
805
]
],
[
[
147,
24,
283
],
[
283,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfopristin"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Vinblastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dalfopristin (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Vinblastine ma... |
DB01173 | DB11130 | 358 | 407 | [
"DDInter1349",
"DDInter1344"
] | Orphenadrine | Opium | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
358,
24,
407
]
],
[
[
358,
74,
662
],
[
662,
24,
407
]
],
[
[
358,
63,
104
],
[
104,
24,
407
]
],
[
[
358,
24,
849
],
[
849,
24,... | [
[
[
"Orphenadrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Orphenadrine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken wi... | Orphenadrine (Compound) resembles Carbinoxamine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Orphenadrine may cause a moderate interaction ... |
DB00476 | DB00938 | 109 | 455 | [
"DDInter608",
"DDInter1635"
] | Duloxetine | Salmeterol | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
109,
24,
455
]
],
[
[
109,
24,
688
],
[
688,
63,
455
]
],
[
[
109,
7,
1986
],
[
1986,
46,
455
]
],
[
[
109,
21,
29095
],
[
29095,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Duloxetine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Salmeterol (Compound)
Duloxe... |
DB01229 | DB01232 | 973 | 1,327 | [
"DDInter1377",
"DDInter1640"
] | Paclitaxel | Saquinavir | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
973,
25,
1327
]
],
[
[
973,
64,
798
],
[
798,
40,
1327
]
],
[
[
973,
6,
10417
],
[
10417,
45,
1327
]
],
[
[
973,
21,
29198
],
[
29198,... | [
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nelfinavir"
],
[
"Nelfinavir",
"{u} (... | Paclitaxel may lead to a major life threatening interaction when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Paclitaxel (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Saquinavir (Compound)
Paclitaxel (Compound) causes Renal failure acute (Side Effect) and Renal failure ac... |
DB00108 | DB01229 | 1,066 | 973 | [
"DDInter1268",
"DDInter1377"
] | Natalizumab | Paclitaxel | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Major | 2 | [
[
[
1066,
25,
973
]
],
[
[
1066,
25,
310
],
[
310,
63,
973
]
],
[
[
1066,
25,
134
],
[
134,
24,
973
]
],
[
[
1066,
24,
748
],
[
748,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitaxel",
"{... | Natalizumab may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Natalizumab may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine may cause a moderat... |
DB00349 | DB14724 | 902 | 48 | [
"DDInter401",
"DDInter634"
] | Clobazam | Emapalumab | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
902,
24,
48
]
],
[
[
902,
62,
1031
],
[
1031,
24,
48
]
],
[
[
902,
40,
1382
],
[
1382,
24,
48
]
],
[
[
902,
63,
608
],
[
608,
24... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Clobazam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Theophylline"
],
[
... | Clobazam may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Clobazam (Compound) resembles Midazolam (Compound) and Midazolam may cause a moderate interaction that could exa... |
DB00502 | DB08899 | 1,300 | 129 | [
"DDInter853",
"DDInter649"
] | Haloperidol | Enzalutamide | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1300,
25,
129
]
],
[
[
1300,
25,
918
],
[
918,
1,
129
]
],
[
[
1300,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1300,
21,
28703
],
[
28703,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
... | Haloperidol may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Haloperidol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Haloperidol (Compound) causes Pruritus (Side Effect) and Pruritus (Side... |
DB00358 | DB09104 | 1,010 | 286 | [
"DDInter1140",
"DDInter1118"
] | Mefloquine | Magnesium hydroxide | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1010,
24,
286
]
],
[
[
1010,
24,
820
],
[
820,
23,
286
]
],
[
[
1010,
63,
88
],
[
88,
23,
286
]
],
[
[
1010,
24,
859
],
[
859,
2... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol a... |
DB09054 | DB12267 | 384 | 1,476 | [
"DDInter905",
"DDInter233"
] | Idelalisib | Brigatinib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
384,
25,
1476
]
],
[
[
384,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
384,
64,
1135
],
[
1135,
23,
1476
]
],
[
[
384,
63,
168
],
[
168,
... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
"Fostemsav... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Idelalisib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a ... |
DB00374 | DB06228 | 1,061 | 792 | [
"DDInter1852",
"DDInter1609"
] | Treprostinil | Rivaroxaban | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
1061,
25,
792
]
],
[
[
1061,
24,
453
],
[
453,
40,
792
]
],
[
[
1061,
7,
7483
],
[
7483,
46,
792
]
],
[
[
1061,
21,
28703
],
[
28703,
... | [
[
[
"Treprostinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
],
[
"Linezo... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Linezolid and Linezolid (Compound) resembles Rivaroxaban (Compound)
Treprostinil (Compound) upregulates HLA-DMA (Gene) and HLA-DMA (Gene) is upregulated by Rivaroxaban (Compound)
Treprostinil (Compound) causes Pruritus (Side Ef... |
DB00569 | DB00586 | 553 | 1,512 | [
"DDInter775",
"DDInter537"
] | Fondaparinux | Diclofenac | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Major | 2 | [
[
[
553,
25,
1512
]
],
[
[
553,
25,
1263
],
[
1263,
63,
1512
]
],
[
[
553,
21,
28880
],
[
28880,
60,
1512
]
],
[
[
553,
23,
297
],
[
297,
... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diclofenac"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bromfenac"
],
[
"Bromfenac",
"{u}... | Fondaparinux may lead to a major life threatening interaction when taken with Bromfenac and Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Fondaparinux (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Diclofenac (Compound)
Fondapa... |
DB00414 | DB00988 | 590 | 817 | [
"DDInter16",
"DDInter584"
] | Acetohexamide | Dopamine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Moderate | 1 | [
[
[
590,
24,
817
]
],
[
[
590,
24,
532
],
[
532,
1,
817
]
],
[
[
590,
23,
1551
],
[
1551,
1,
817
]
],
[
[
590,
24,
1148
],
[
1148,
6... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) resembles Dopamine (Compound)
Acetohexamide may cause a minor interaction that can limit clinical effects when taken with Methyldopa and Methyldopa (Compound) resembles Dopamine (Compound)
... |
DB01211 | DB08875 | 609 | 1,618 | [
"DDInter393",
"DDInter262"
] | Clarithromycin | Cabozantinib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
609,
25,
1618
]
],
[
[
609,
25,
1135
],
[
1135,
62,
1618
]
],
[
[
609,
62,
112
],
[
112,
23,
1618
]
],
[
[
609,
63,
723
],
[
723,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Clarithromycin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole ... |
DB00853 | DB09074 | 1,686 | 1,362 | [
"DDInter1762",
"DDInter1327"
] | Temozolomide | Olaparib | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1686,
24,
1362
]
],
[
[
1686,
63,
896
],
[
896,
24,
1362
]
],
[
[
1686,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
1686,
24,
385
],
[
385,
... | [
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustek... |
DB04845 | DB06643 | 309 | 1,136 | [
"DDInter1001",
"DDInter500"
] | Ixabepilone | Denosumab | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
309,
24,
1136
]
],
[
[
309,
63,
1213
],
[
1213,
24,
1136
]
],
[
[
309,
24,
1480
],
[
1480,
63,
1136
]
],
[
[
309,
24,
1626
],
[
1626,
... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib ... |
DB01501 | DB04948 | 1,118 | 1,084 | [
"DDInter549",
"DDInter1083"
] | Difenoxin | Lofexidine | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
1118,
24,
1084
]
],
[
[
1118,
63,
1617
],
[
1617,
1,
1084
]
],
[
[
1118,
63,
530
],
[
530,
24,
1084
]
],
[
[
1118,
24,
1609
],
[
1609,... | [
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
[
... | Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that c... |
DB06700 | DB12364 | 643 | 1,421 | [
"DDInter511",
"DDInter200"
] | Desvenlafaxine | Betrixaban | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
643,
24,
1421
]
],
[
[
643,
64,
1039
],
[
1039,
24,
1421
]
],
[
[
643,
63,
478
],
[
478,
24,
1421
]
],
[
[
643,
40,
1100
],
[
1100,
... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Desvenlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
... | Desvenlafaxine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilo... |
DB00970 | DB06688 | 0 | 1,430 | [
"DDInter466",
"DDInter1677"
] | Dactinomycin | Sipuleucel-T | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
0,
24,
1430
]
],
[
[
0,
63,
51
],
[
51,
24,
1430
]
],
[
[
0,
24,
869
],
[
869,
24,
1430
]
],
[
[
0,
25,
676
],
[
676,
63,
... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Topotecan a... |
DB01218 | DB08899 | 1,493 | 129 | [
"DDInter852",
"DDInter649"
] | Halofantrine | Enzalutamide | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1493,
25,
129
]
],
[
[
1493,
64,
918
],
[
918,
1,
129
]
],
[
[
1493,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1493,
21,
28703
],
[
28703,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
... | Halofantrine may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Halofantrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Halofantrine (Compound) causes Pruritus (Side Effect) and Pruritus (S... |
DB00445 | DB15762 | 322 | 725 | [
"DDInter655",
"DDInter1644"
] | Epirubicin | Satralizumab | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Moderate | 1 | [
[
[
322,
24,
725
]
],
[
[
322,
24,
1362
],
[
1362,
24,
725
]
],
[
[
322,
63,
134
],
[
134,
24,
725
]
],
[
[
322,
64,
1066
],
[
1066,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorel... |
DB00163 | DB00242 | 1,461 | 1,064 | [
"DDInter1943",
"DDInter392"
] | Vitamin E | Cladribine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Moderate | 1 | [
[
[
1461,
24,
1064
]
],
[
[
1461,
24,
1426
],
[
1426,
64,
1064
]
],
[
[
1461,
18,
15501
],
[
15501,
57,
1064
]
],
[
[
1461,
24,
869
],
[
8... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cladribine"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine may lead to a major life threatening interaction when taken with Cladribine
Vitamin E (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Cladribine (Compound)
Vitamin E may cau... |
DB00476 | DB01233 | 109 | 1,311 | [
"DDInter608",
"DDInter1197"
] | Duloxetine | Metoclopramide | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
109,
24,
1311
]
],
[
[
109,
6,
12523
],
[
12523,
45,
1311
]
],
[
[
109,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
109,
24,
1479
],
[
147... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Duloxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Duloxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metoclopramide (Compound)
Duloxetine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsal... |
DB00284 | DB00865 | 1,647 | 939 | [
"DDInter11",
"DDInter187"
] | Acarbose | Benzphetamine | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Moderate | 1 | [
[
[
1647,
24,
939
]
],
[
[
1647,
24,
1529
],
[
1529,
1,
939
]
],
[
[
1647,
24,
401
],
[
401,
63,
939
]
],
[
[
1647,
63,
362
],
[
362,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Benzphetamine (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB00618 | DB01337 | 1,572 | 1,579 | [
"DDInter498",
"DDInter1385"
] | Demeclocycline | Pancuronium | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release. | Moderate | 1 | [
[
[
1572,
24,
1579
]
],
[
[
1572,
24,
1610
],
[
1610,
1,
1579
]
],
[
[
1572,
24,
544
],
[
544,
24,
1579
]
],
[
[
1572,
63,
1031
],
[
1031,... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pancuronium"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rocuronium"
],... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium and Rocuronium (Compound) resembles Pancuronium (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate... |
DB00373 | DB11921 | 461 | 1,019 | [
"DDInter1809",
"DDInter492"
] | Timolol | Deflazacort | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
461,
24,
1019
]
],
[
[
461,
24,
959
],
[
959,
24,
1019
]
],
[
[
461,
23,
286
],
[
286,
24,
1019
]
],
[
[
461,
63,
176
],
[
176,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
"G... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Timolol may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide and Magnes... |
DB00468 | DB08870 | 1,424 | 850 | [
"DDInter1557",
"DDInter228"
] | Quinine | Brentuximab vedotin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1424,
24,
850
]
],
[
[
1424,
63,
1570
],
[
1570,
24,
850
]
],
[
[
1424,
24,
859
],
[
859,
24,
850
]
],
[
[
1424,
24,
1155
],
[
1155,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Posaconazole a... |
DB03904 | DB10675 | 1,574 | 961 | [
"DDInter1903",
"DDInter1065"
] | Urea | Licorice | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Licorice allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
1574,
24,
961
]
],
[
[
1574,
24,
28
],
[
28,
63,
870
],
[
870,
24,
961
]
],
[
[
1574,
63,
317
],
[
317,
24,
870
],
[
870,
24,
... | [
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Licorice"
]
],
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
],
[
"Bisacodyl"... | Urea may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Urea m... |
DB00539 | DB08868 | 11 | 1,011 | [
"DDInter1837",
"DDInter737"
] | Toremifene | Fingolimod | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
11,
25,
1011
]
],
[
[
11,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
11,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
11,
23,
1247
],
[
1247,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingoli... | Toremifene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Toremifene (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Toremifene may cause a minor interaction that can limit clinical effects when ... |
DB00352 | DB15091 | 482 | 676 | [
"DDInter1814",
"DDInter1901"
] | Tioguanine | Upadacitinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
482,
25,
676
]
],
[
[
482,
63,
1461
],
[
1461,
23,
676
]
],
[
[
482,
24,
1430
],
[
1430,
24,
676
]
],
[
[
482,
63,
600
],
[
600,
... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipule... |
DB00712 | DB00939 | 1,274 | 1,338 | [
"DDInter763",
"DDInter1135"
] | Flurbiprofen | Meclofenamic acid | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
1274,
24,
1338
]
],
[
[
1274,
40,
345
],
[
345,
1,
1338
]
],
[
[
1274,
24,
1479
],
[
1479,
63,
1338
]
],
[
[
1274,
6,
10522
],
[
10522... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) resembles {v} (Compound)",
"Salsalate"
],
[
"Salsalate",
"{u} (Compound)... | Flurbiprofen (Compound) resembles Salsalate (Compound) and Salsalate (Compound) resembles Meclofenamic acid (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate disease... |
DB06636 | DB08816 | 1,623 | 578 | [
"DDInter980",
"DDInter1802"
] | Isavuconazonium | Ticagrelor | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1623,
24,
578
]
],
[
[
1623,
25,
1135
],
[
1135,
62,
578
]
],
[
[
1623,
63,
723
],
[
723,
24,
578
]
],
[
[
1623,
24,
868
],
[
868,
... | [
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Isavuconazonium",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"N... | Isavuconazonium may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Isavuconazonium may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may ... |
DB00380 | DB14783 | 145 | 287 | [
"DDInter522",
"DDInter574"
] | Dexrazoxane | Diroximel fumarate | An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug ... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
145,
24,
287
]
],
[
[
145,
24,
713
],
[
713,
25,
287
]
],
[
[
145,
6,
3930
],
[
3930,
45,
51
],
[
51,
24,
287
]
],
[
[
145,
24,
... | [
[
[
"Dexrazoxane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Dexrazoxane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate... | Dexrazoxane may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may lead to a major life threatening interaction when taken with Diroximel fumarate
Dexrazoxane (Compound) binds TOP2B (Gene) and TOP2B (Gene) is bound by Daunorubicin (Compound) and Dauno... |
DB00087 | DB00851 | 599 | 611 | [
"DDInter41",
"DDInter463"
] | Alemtuzumab | Dacarbazine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
599,
24,
611
]
],
[
[
599,
24,
141
],
[
141,
24,
611
]
],
[
[
599,
24,
850
],
[
850,
63,
611
]
],
[
[
599,
63,
305
],
[
305,
24,... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedo... |
DB00363 | DB01409 | 695 | 1,415 | [
"DDInter419",
"DDInter1815"
] | Clozapine | Tiotropium | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
695,
24,
1415
]
],
[
[
695,
6,
4304
],
[
4304,
45,
1415
]
],
[
[
695,
24,
752
],
[
752,
23,
1415
]
],
[
[
695,
24,
1594
],
[
1594,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CHRM2"
],
[
"CHRM2",
"{u} (Gene) is bound by {v} (Compound)",
... | Clozapine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Tiotropium (Compound)
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Tiotropium
Clozapine may cause a mo... |
DB08870 | DB10315 | 850 | 1,137 | [
"DDInter228",
"DDInter1127"
] | Brentuximab vedotin | Measles virus vaccine live attenuated | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
850,
25,
1137
]
],
[
[
850,
64,
581
],
[
581,
25,
1137
]
],
[
[
850,
24,
384
],
[
384,
25,
1137
]
],
[
[
850,
63,
1101
],
[
1101,
... | [
[
[
"Brentuximab vedotin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Brentuximab vedotin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
... | Brentuximab vedotin may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Idelal... |
DB00831 | DB00986 | 1,178 | 1,192 | [
"DDInter1866",
"DDInter834"
] | Trifluoperazine | Glycopyrronium | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
1178,
24,
1192
]
],
[
[
1178,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
1178,
63,
262
],
[
262,
24,
1192
]
],
[
[
1178,
6,
4304
],
[
4304,... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Clidi... |
DB00308 | DB09134 | 347 | 1,552 | [
"DDInter901",
"DDInter966"
] | Ibutilide | Ioversol | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
347,
24,
1552
]
],
[
[
347,
40,
17
],
[
17,
24,
1552
]
],
[
[
347,
25,
485
],
[
485,
25,
1552
]
],
[
[
347,
40,
17
],
[
17,
1,
... | [
[
[
"Ibutilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Ibutilide",
"{u} (Compound) resembles {v} (Compound)",
"Sotalol"
],
[
"Sotalol",
"{u} may cause a moderate interact... | Ibutilide (Compound) resembles Sotalol (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Ibutilide may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may lead to a major life threatening interaction when taken with I... |
DB00342 | DB01591 | 1,181 | 667 | [
"DDInter1770",
"DDInter1696"
] | Terfenadine | Solifenacin | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
1181,
24,
667
]
],
[
[
1181,
23,
112
],
[
112,
23,
667
]
],
[
[
1181,
24,
774
],
[
774,
63,
667
]
],
[
[
1181,
24,
392
],
[
392,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Solifenacin
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and De... |
DB00444 | DB08860 | 63 | 788 | [
"DDInter1765",
"DDInter1479"
] | Teniposide | Pitavastatin | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
63,
24,
788
]
],
[
[
63,
24,
671
],
[
671,
1,
788
]
],
[
[
63,
24,
700
],
[
700,
40,
788
]
],
[
[
63,
6,
17404
],
[
17404,
45,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin (... |
DB00334 | DB09045 | 867 | 52 | [
"DDInter1326",
"DDInter607"
] | Olanzapine | Dulaglutide | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
867,
24,
52
]
],
[
[
867,
24,
170
],
[
170,
23,
52
]
],
[
[
867,
24,
609
],
[
609,
24,
52
]
],
[
[
867,
24,
1296
],
[
1296,
63,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and C... |
DB00224 | DB14568 | 215 | 982 | [
"DDInter917",
"DDInter1000"
] | Indinavir | Ivosidenib | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
215,
25,
982
]
],
[
[
215,
63,
168
],
[
168,
23,
982
]
],
[
[
215,
24,
1101
],
[
1101,
23,
982
]
],
[
[
215,
25,
976
],
[
976,
2... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene... |
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