drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00468 | DB15328 | 1,424 | 829 | [
"DDInter1557",
"DDInter1896"
] | Quinine | Ubrogepant | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
1424,
24,
829
]
],
[
[
1424,
24,
1476
],
[
1476,
24,
829
]
],
[
[
1424,
25,
868
],
[
868,
24,
829
]
],
[
[
1424,
63,
1051
],
[
1051,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
"B... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Quinine may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a mo... |
DB01118 | DB01211 | 33 | 609 | [
"DDInter76",
"DDInter393"
] | Amiodarone | Clarithromycin | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
33,
25,
609
]
],
[
[
33,
6,
4973
],
[
4973,
45,
609
]
],
[
[
33,
7,
5727
],
[
5727,
46,
609
]
],
[
[
33,
54,
19146
],
[
19146,
1... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Amiodarone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Clari... | Amiodarone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Amiodarone (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Clarithromycin (Compound)
Amiodarone (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhi... |
DB00741 | DB06292 | 167 | 549 | [
"DDInter885",
"DDInter474"
] | Hydrocortisone | Dapagliflozin | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
167,
24,
549
]
],
[
[
167,
24,
1344
],
[
1344,
40,
549
]
],
[
[
167,
6,
8374
],
[
8374,
45,
549
]
],
[
[
167,
21,
28882
],
[
28882,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Hydrocortisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Hydrocortisone (Compound) causes Body temperat... |
DB00048 | DB06209 | 1,595 | 256 | [
"DDInter435",
"DDInter1508"
] | Collagenase clostridium histolyticum | Prasugrel | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Moderate | 1 | [
[
[
1595,
24,
256
]
],
[
[
1595,
24,
1479
],
[
1479,
24,
256
]
],
[
[
1595,
24,
578
],
[
578,
63,
256
]
],
[
[
1595,
24,
1317
],
[
1317,
... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when ... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel
Collagenase clostridium histolyticum may cause a moderate interacti... |
DB00631 | DB06710 | 372 | 1,546 | [
"DDInter405",
"DDInter1193"
] | Clofarabine | Methyltestosterone | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
372,
24,
1546
]
],
[
[
372,
24,
155
],
[
155,
1,
1546
]
],
[
[
372,
24,
984
],
[
984,
40,
1546
]
],
[
[
372,
63,
1026
],
[
1026,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Methyltestosterone (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Methylte... |
DB00673 | DB08930 | 723 | 1,459 | [
"DDInter112",
"DDInter582"
] | Aprepitant | Dolutegravir | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and ... | Minor | 0 | [
[
[
723,
23,
1459
]
],
[
[
723,
21,
28698
],
[
28698,
60,
1459
]
],
[
[
723,
63,
353
],
[
353,
23,
1459
]
],
[
[
723,
24,
478
],
[
478,
... | [
[
[
"Aprepitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dolutegravir"
]
],
[
[
"Aprepitant",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caused... | Aprepitant (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Dolutegravir (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Dolut... |
DB06228 | DB14568 | 792 | 982 | [
"DDInter1609",
"DDInter1000"
] | Rivaroxaban | Ivosidenib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
792,
24,
982
]
],
[
[
792,
63,
1101
],
[
1101,
23,
982
]
],
[
[
792,
24,
241
],
[
241,
24,
982
]
],
[
[
792,
25,
503
],
[
503,
6... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib and Erdaf... |
DB00004 | DB06674 | 669 | 908 | [
"DDInter499",
"DDInter837"
] | Denileukin diftitox | Golimumab | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
669,
25,
908
]
],
[
[
669,
24,
200
],
[
200,
63,
908
]
],
[
[
669,
24,
1136
],
[
1136,
24,
908
]
],
[
[
669,
25,
334
],
[
334,
6... | [
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
... | Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when tak... |
DB00741 | DB01208 | 167 | 945 | [
"DDInter885",
"DDInter1705"
] | Hydrocortisone | Sparfloxacin | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
167,
25,
945
]
],
[
[
167,
25,
739
],
[
739,
1,
945
]
],
[
[
167,
64,
1176
],
[
1176,
1,
945
]
],
[
[
167,
6,
4973
],
[
4973,
45... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin"... | Hydrocortisone may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Hydrocortisone may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (Compound)
Hydrocorti... |
DB00836 | DB08868 | 543 | 1,011 | [
"DDInter1088",
"DDInter737"
] | Loperamide | Fingolimod | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
543,
24,
1011
]
],
[
[
543,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
543,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
543,
24,
112
],
[
112,... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Loperamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Loperamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Loperamide (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases whe... |
DB01006 | DB12010 | 300 | 214 | [
"DDInter1040",
"DDInter785"
] | Letrozole | Fostamatinib | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
300,
24,
214
]
],
[
[
300,
63,
723
],
[
723,
24,
214
]
],
[
[
300,
62,
307
],
[
307,
24,
214
]
],
[
[
300,
24,
179
],
[
179,
63,... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Letrozole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil... |
DB00701 | DB08896 | 1,091 | 292 | [
"DDInter90",
"DDInter1576"
] | Amprenavir | Regorafenib | Amprenavir is a protease inhibitor used to treat HIV infection. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
1091,
24,
292
]
],
[
[
1091,
6,
6017
],
[
6017,
45,
292
]
],
[
[
1091,
21,
28890
],
[
28890,
60,
292
]
],
[
[
1091,
24,
549
],
[
549,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Amprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)"... | Amprenavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Amprenavir (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Regorafenib (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases when take... |
DB08899 | DB11110 | 129 | 603 | [
"DDInter649",
"DDInter1115"
] | Enzalutamide | Magnesium citrate | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
129,
24,
603
]
],
[
[
129,
64,
57
],
[
57,
24,
603
]
],
[
[
129,
63,
789
],
[
789,
24,
603
]
],
[
[
129,
25,
484
],
[
484,
63,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Enzalutamide may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and... |
DB00641 | DB09570 | 467 | 1,480 | [
"DDInter1675",
"DDInter1002"
] | Simvastatin | Ixazomib | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
467,
24,
1480
]
],
[
[
467,
63,
268
],
[
268,
24,
1480
]
],
[
[
467,
24,
148
],
[
148,
63,
1480
]
],
[
[
467,
24,
98
],
[
98,
24... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00208 | DB00390 | 1,018 | 1,252 | [
"DDInter1804",
"DDInter554"
] | Ticlopidine | Digoxin | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Minor | 0 | [
[
[
1018,
23,
1252
]
],
[
[
1018,
6,
8374
],
[
8374,
45,
1252
]
],
[
[
1018,
18,
10375
],
[
10375,
57,
1252
]
],
[
[
1018,
21,
28784
],
[
... | [
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Digoxin"
]
],
[
[
"Ticlopidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Ticlopidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Digoxin (Compound)
Ticlopidine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Digoxin (Compound)
Ticlopidine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Digoxin (Co... |
DB00791 | DB08880 | 132 | 1,510 | [
"DDInter1902",
"DDInter1771"
] | Uracil mustard | Teriflunomide | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
132,
25,
1510
]
],
[
[
132,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
132,
24,
221
],
[
221,
63,
1510
]
],
[
[
132,
24,
1136
],
[
1136,
... | [
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus typ... |
DB00222 | DB01250 | 245 | 712 | [
"DDInter825",
"DDInter1334"
] | Glimepiride | Olsalazine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
245,
24,
712
]
],
[
[
245,
24,
50
],
[
50,
40,
712
]
],
[
[
245,
24,
914
],
[
914,
24,
712
]
],
[
[
245,
24,
126
],
[
126,
23,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause a moderate interaction th... |
DB04951 | DB09330 | 187 | 985 | [
"DDInter1477",
"DDInter1352"
] | Pirfenidone | Osimertinib | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
187,
24,
985
]
],
[
[
187,
62,
168
],
[
168,
23,
985
]
],
[
[
187,
24,
1478
],
[
1478,
24,
985
]
],
[
[
187,
63,
663
],
[
663,
2... | [
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Pirfenidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Pirfenidone may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacafto... |
DB00086 | DB00472 | 1,167 | 758 | [
"DDInter1712",
"DDInter758"
] | Streptokinase | Fluoxetine | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
1167,
24,
758
]
],
[
[
1167,
24,
109
],
[
109,
40,
758
]
],
[
[
1167,
25,
936
],
[
936,
63,
758
]
],
[
[
1167,
24,
714
],
[
714,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compound)
Streptokinase may lead to a major life threatening interaction when taken with Cangrelor and Cangrelor may cause a moderate interaction that could exacerbate... |
DB01319 | DB09330 | 34 | 985 | [
"DDInter777",
"DDInter1352"
] | Fosamprenavir | Osimertinib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
34,
25,
985
]
],
[
[
34,
63,
168
],
[
168,
23,
985
]
],
[
[
34,
64,
608
],
[
608,
23,
985
]
],
[
[
34,
25,
1478
],
[
1478,
24,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bor... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Fosamprenavir may lead to a major life threatening interaction when taken with Lidocaine and Lidocaine may cau... |
DB00224 | DB09065 | 215 | 760 | [
"DDInter917",
"DDInter424"
] | Indinavir | Cobicistat | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
215,
24,
760
]
],
[
[
215,
24,
1101
],
[
1101,
23,
760
]
],
[
[
215,
23,
1374
],
[
1374,
23,
760
]
],
[
[
215,
24,
1041
],
[
1041,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Indinavir may cause a minor interaction that can limit clinical effects when taken with Abiraterone and Abiraterone... |
DB00635 | DB00903 | 1,573 | 1,680 | [
"DDInter1515",
"DDInter686"
] | Prednisone | Etacrynic acid | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Moderate | 1 | [
[
[
1573,
24,
1680
]
],
[
[
1573,
6,
1829
],
[
1829,
45,
1680
]
],
[
[
1573,
21,
28882
],
[
28882,
60,
1680
]
],
[
[
1573,
24,
1479
],
[
1... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etacrynic acid"
]
],
[
[
"Prednisone",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Prednisone (Compound) binds ALB (Gene) and ALB (Gene) is bound by Etacrynic acid (Compound)
Prednisone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Etacrynic acid (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases... |
DB04868 | DB08816 | 478 | 578 | [
"DDInter1293",
"DDInter1802"
] | Nilotinib | Ticagrelor | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
478,
24,
578
]
],
[
[
478,
6,
4973
],
[
4973,
45,
578
]
],
[
[
478,
21,
28646
],
[
28646,
60,
578
]
],
[
[
478,
63,
336
],
[
336,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Nilotinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nilotinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Nilotinib (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Nilotinib may cause a modera... |
DB00641 | DB13179 | 467 | 68 | [
"DDInter1675",
"DDInter1882"
] | Simvastatin | Troleandomycin | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
467,
25,
68
]
],
[
[
467,
63,
1101
],
[
1101,
23,
68
]
],
[
[
467,
24,
466
],
[
466,
23,
68
]
],
[
[
467,
24,
309
],
[
309,
24,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexa... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and ... |
DB01236 | DB14568 | 679 | 982 | [
"DDInter1664",
"DDInter1000"
] | Sevoflurane | Ivosidenib | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
679,
25,
982
]
],
[
[
679,
62,
112
],
[
112,
23,
982
]
],
[
[
679,
63,
543
],
[
543,
24,
982
]
],
[
[
679,
24,
28
],
[
28,
24,
... | [
[
[
"Sevoflurane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Sevoflurane",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Sevoflurane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Lo... |
DB00039 | DB04845 | 1,253 | 309 | [
"DDInter1380",
"DDInter1001"
] | Palifermin | Ixabepilone | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1253,
24,
309
]
],
[
[
1253,
24,
60
],
[
60,
23,
309
]
],
[
[
1253,
24,
1419
],
[
1419,
24,
309
]
],
[
[
1253,
24,
1619
],
[
1619,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
],
[... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Ixabepilone
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imati... |
DB00060 | DB01009 | 912 | 935 | [
"DDInter947",
"DDInter1009"
] | Interferon beta-1a | Ketoprofen | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
912,
24,
935
]
],
[
[
912,
24,
1523
],
[
1523,
40,
935
]
],
[
[
912,
24,
847
],
[
847,
1,
935
]
],
[
[
912,
24,
1274
],
[
1274,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ketoprofen (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Ketopr... |
DB00281 | DB01226 | 608 | 1,319 | [
"DDInter1066",
"DDInter1235"
] | Lidocaine | Mivacurium | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. | Moderate | 1 | [
[
[
608,
24,
1319
]
],
[
[
608,
24,
648
],
[
648,
1,
1319
]
],
[
[
608,
21,
28921
],
[
28921,
60,
1319
]
],
[
[
608,
23,
1220
],
[
1220,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mivacurium"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxacurium"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Doxacurium and Doxacurium (Compound) resembles Mivacurium (Compound)
Lidocaine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Mivacurium (Compound)
Lidocaine may cause a minor interaction that c... |
DB04835 | DB06595 | 1,655 | 1,491 | [
"DDInter1125",
"DDInter1214"
] | Maraviroc | Midostaurin | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1655,
24,
1491
]
],
[
[
1655,
63,
888
],
[
888,
24,
1491
]
],
[
[
1655,
24,
1017
],
[
1017,
63,
1491
]
],
[
[
1655,
64,
1377
],
[
1377... | [
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[
... | Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatini... |
DB04868 | DB08916 | 478 | 26 | [
"DDInter1293",
"DDInter32"
] | Nilotinib | Afatinib | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
478,
24,
26
]
],
[
[
478,
63,
883
],
[
883,
40,
26
]
],
[
[
478,
6,
4973
],
[
4973,
45,
26
]
],
[
[
478,
34,
2030
],
[
2030,
45,... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Nilotinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Nilotinib (Compound) binds ABL1 (Gene) and Nilotinib (Compound) upregulates ... |
DB00906 | DB08912 | 1,567 | 1,040 | [
"DDInter1801",
"DDInter462"
] | Tiagabine | Dabrafenib | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1567,
24,
1040
]
],
[
[
1567,
6,
8374
],
[
8374,
45,
1040
]
],
[
[
1567,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
1567,
63,
1101
],
[
1... | [
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Tiagabine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tiagabine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound)
Tiagabine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene a... |
DB00432 | DB14444 | 1,083 | 151 | [
"DDInter1868",
"DDInter924"
] | Trifluridine | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1083,
24,
151
]
],
[
[
1083,
63,
66
],
[
66,
24,
151
]
],
[
[
1083,
24,
869
],
[
869,
24,
151
]
],
[
[
1083,
25,
375
],
[
375,
2... | [
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Trifluridine",
"{u} may cause a moderate interaction that cou... | Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Trifluridine may cause a moderate i... |
DB00344 | DB09065 | 1,302 | 760 | [
"DDInter1543",
"DDInter424"
] | Protriptyline | Cobicistat | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1302,
24,
760
]
],
[
[
1302,
24,
1374
],
[
1374,
23,
760
]
],
[
[
1302,
25,
868
],
[
868,
24,
760
]
],
[
[
1302,
24,
609
],
[
609,
... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Protriptyline may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib ma... |
DB00976 | DB06176 | 1,056 | 1,342 | [
"DDInter1758",
"DDInter1616"
] | Telithromycin | Romidepsin | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1056,
24,
1342
]
],
[
[
1056,
62,
112
],
[
112,
23,
1342
]
],
[
[
1056,
63,
485
],
[
485,
24,
1342
]
],
[
[
1056,
24,
1520
],
[
1520,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Telithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Telithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine a... |
DB00526 | DB01206 | 1,555 | 37 | [
"DDInter1355",
"DDInter1086"
] | Oxaliplatin | Lomustine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
1555,
24,
37
]
],
[
[
1555,
64,
1176
],
[
1176,
23,
37
]
],
[
[
1555,
24,
956
],
[
956,
23,
37
]
],
[
[
1555,
25,
945
],
[
945,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxiflo... | Oxaliplatin may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Lomustine
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin may c... |
DB00603 | DB00745 | 303 | 307 | [
"DDInter1137",
"DDInter1236"
] | Medroxyprogesterone acetate | Modafinil | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Moderate | 1 | [
[
[
303,
24,
307
]
],
[
[
303,
63,
362
],
[
362,
40,
307
]
],
[
[
303,
24,
651
],
[
651,
40,
307
]
],
[
[
303,
6,
8374
],
[
8374,
45... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Modafinil (Compound)
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin (Compoun... |
DB00694 | DB00773 | 51 | 896 | [
"DDInter485",
"DDInter702"
] | Daunorubicin | Etoposide | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
51,
24,
896
]
],
[
[
51,
5,
11555
],
[
11555,
44,
896
]
],
[
[
51,
6,
10417
],
[
10417,
45,
896
]
],
[
[
51,
7,
7972
],
[
7972,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Daunorubicin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Dis... | Daunorubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Etoposide (Compound)
Daunorubicin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Etoposide (Compound)
Daunorubicin (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Etoposide (... |
DB00023 | DB11817 | 305 | 1,259 | [
"DDInter127",
"DDInter165"
] | Asparaginase Escherichia coli | Baricitinib | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
305,
25,
1259
]
],
[
[
305,
24,
1274
],
[
1274,
24,
1259
]
],
[
[
305,
24,
1129
],
[
1129,
63,
1259
]
],
[
[
305,
24,
384
],
[
384,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flu... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate dis... |
DB00418 | DB08895 | 536 | 976 | [
"DDInter1650",
"DDInter1825"
] | Secobarbital | Tofacitinib | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
536,
24,
976
]
],
[
[
536,
24,
214
],
[
214,
63,
976
]
],
[
[
536,
24,
723
],
[
723,
24,
976
]
],
[
[
536,
64,
475
],
[
475,
24,... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant a... |
DB11827 | DB11921 | 433 | 1,019 | [
"DDInter669",
"DDInter492"
] | Ertugliflozin | Deflazacort | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
433,
24,
1019
]
],
[
[
433,
63,
1072
],
[
1072,
23,
1019
]
],
[
[
433,
63,
192
],
[
192,
24,
1019
]
],
[
[
433,
24,
1654
],
[
1654,
... | [
[
[
"Ertugliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Ertugliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
... | Ertugliflozin may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Ertugliflozin may cause a moderate interaction that could exacerbate diseases when taken with Esterified estroge... |
DB00486 | DB01200 | 1,614 | 469 | [
"DDInter1253",
"DDInter243"
] | Nabilone | Bromocriptine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
1614,
24,
469
]
],
[
[
1614,
21,
28787
],
[
28787,
60,
469
]
],
[
[
1614,
24,
401
],
[
401,
24,
469
]
],
[
[
1614,
63,
701
],
[
701,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Nabilone",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is cau... | Nabilone (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Bromocriptine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Br... |
DB00647 | DB09472 | 675 | 1,383 | [
"DDInter528",
"DDInter1693"
] | Dextropropoxyphene | Sodium sulfate | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
675,
24,
1383
]
],
[
[
675,
24,
609
],
[
609,
24,
1383
]
],
[
[
675,
25,
1311
],
[
1311,
24,
1383
]
],
[
[
675,
63,
521
],
[
521,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarith... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Dextropropoxyphene may lead to a major life threatening interaction when taken with Metoclop... |
DB00595 | DB00999 | 1,545 | 504 | [
"DDInter1374",
"DDInter883"
] | Oxytetracycline | Hydrochlorothiazide | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Minor | 0 | [
[
[
1545,
23,
504
]
],
[
[
1545,
23,
1326
],
[
1326,
40,
504
]
],
[
[
1545,
23,
178
],
[
178,
1,
504
]
],
[
[
1545,
6,
10612
],
[
10612,
... | [
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Diclofenamid... | Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Polythiazide and Polythiazide (Compound) resembl... |
DB00333 | DB09036 | 576 | 812 | [
"DDInter1166",
"DDInter1668"
] | Methadone | Siltuximab | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
576,
24,
812
]
],
[
[
576,
24,
259
],
[
259,
24,
812
]
],
[
[
576,
1,
494
],
[
494,
24,
812
]
],
[
[
576,
63,
1184
],
[
1184,
24... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab
Methadone (Compound) resembles Disopyramide (Compound) and Disopyramide may cause a moderate interaction that cou... |
DB01168 | DB06701 | 1,053 | 1,177 | [
"DDInter1526",
"DDInter521"
] | Procarbazine | Dexmethylphenidate | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer s... | Major | 2 | [
[
[
1053,
25,
1177
]
],
[
[
1053,
64,
895
],
[
895,
1,
1177
]
],
[
[
1053,
21,
28703
],
[
28703,
60,
1177
]
],
[
[
1053,
62,
126
],
[
126,... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexmethylphenidate"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylphenidate"
],
[
"Methylph... | Procarbazine may lead to a major life threatening interaction when taken with Methylphenidate and Methylphenidate (Compound) resembles Dexmethylphenidate (Compound)
Procarbazine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Dexmethylphenidate (Compound)
Procarbazine may cause a minor ... |
DB00687 | DB01067 | 870 | 959 | [
"DDInter747",
"DDInter826"
] | Fludrocortisone | Glipizide | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
870,
24,
959
]
],
[
[
870,
63,
245
],
[
245,
40,
959
]
],
[
[
870,
24,
1411
],
[
1411,
1,
959
]
],
[
[
870,
21,
28698
],
[
28698,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
]... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide... |
DB00612 | DB06792 | 1,121 | 1,606 | [
"DDInter216",
"DDInter1023"
] | Bisoprolol | Lanthanum carbonate | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
1121,
24,
1606
]
],
[
[
1121,
1,
88
],
[
88,
24,
1606
]
],
[
[
1121,
62,
1152
],
[
1152,
24,
1606
]
],
[
[
1121,
1,
88
],
[
88,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Bisoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Metoprolol"
],
[
"Metoprolol",
"{u} may cause ... | Bisoprolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Bisoprolol may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine may cause a moderate interaction... |
DB08896 | DB11799 | 292 | 627 | [
"DDInter1576",
"DDInter205"
] | Regorafenib | Bictegravir | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Moderate | 1 | [
[
[
292,
24,
627
]
],
[
[
292,
64,
578
],
[
578,
24,
627
]
],
[
[
292,
40,
79
],
[
79,
24,
627
]
],
[
[
292,
63,
609
],
[
609,
24,
... | [
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
]
],
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticagrelor"
],
[
"Ticagre... | Regorafenib may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Regorafenib (Compound) resembles Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate di... |
DB00226 | DB06292 | 1,000 | 549 | [
"DDInter845",
"DDInter474"
] | Guanadrel | Dapagliflozin | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1000,
24,
549
]
],
[
[
1000,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1000,
24,
1636
],
[
1636,
24,
549
]
],
[
[
1000,
63,
1179
],
[
1179,... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interacti... |
DB00059 | DB10315 | 1,560 | 1,137 | [
"DDInter1404",
"DDInter1127"
] | Pegaspargase | Measles virus vaccine live attenuated | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1560,
25,
1137
]
],
[
[
1560,
24,
617
],
[
617,
24,
1137
]
],
[
[
1560,
25,
581
],
[
581,
25,
1137
]
],
[
[
1560,
24,
384
],
[
384,
... | [
[
[
"Pegaspargase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Pegaspargase may lead to a major life threatening interaction when taken with Infli... |
DB00398 | DB00794 | 79 | 759 | [
"DDInter1702",
"DDInter1521"
] | Sorafenib | Primidone | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
79,
24,
759
]
],
[
[
79,
24,
697
],
[
697,
40,
759
]
],
[
[
79,
63,
362
],
[
362,
1,
759
]
],
[
[
79,
6,
6017
],
[
6017,
45,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Compound)
... |
DB00446 | DB01235 | 597 | 1,191 | [
"DDInter351",
"DDInter1054"
] | Chloramphenicol | Levodopa | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
597,
24,
1191
]
],
[
[
597,
24,
1307
],
[
1307,
40,
1191
]
],
[
[
597,
21,
28769
],
[
28769,
60,
1191
]
],
[
[
597,
63,
63
],
[
63,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan (Compound) resembles Levodopa (Compound)
Chloramphenicol (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Levodopa (Compound)
Chloramphenicol may cause ... |
DB00252 | DB11967 | 362 | 710 | [
"DDInter1460",
"DDInter210"
] | Phenytoin | Binimetinib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
362,
24,
710
]
],
[
[
362,
25,
1593
],
[
1593,
24,
710
]
],
[
[
362,
24,
883
],
[
883,
24,
710
]
],
[
[
362,
24,
1619
],
[
1619,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizotinib"... | Phenytoin may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib may cause a m... |
DB00288 | DB06335 | 1,103 | 761 | [
"DDInter63",
"DDInter1646"
] | Amcinonide | Saxagliptin | Amcinonide is a corticosteroid. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Minor | 0 | [
[
[
1103,
23,
761
]
],
[
[
1103,
21,
28703
],
[
28703,
60,
761
]
],
[
[
1103,
1,
1573
],
[
1573,
24,
761
]
],
[
[
1103,
23,
1296
],
[
1296... | [
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Saxagliptin"
]
],
[
[
"Amcinonide",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused ... | Amcinonide (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Saxagliptin (Compound)
Amcinonide (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Amcinonide may cause a minor interaction tha... |
DB00258 | DB00264 | 666 | 88 | [
"DDInter270",
"DDInter1200"
] | Calcium acetate | Metoprolol | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Moderate | 1 | [
[
[
666,
24,
88
]
],
[
[
666,
24,
1121
],
[
1121,
1,
88
]
],
[
[
666,
24,
819
],
[
819,
40,
88
]
],
[
[
666,
21,
28897
],
[
28897,
6... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
]... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Metoprolol (Compound)
Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Metoprolol (... |
DB00046 | DB00852 | 1,179 | 1,445 | [
"DDInter940",
"DDInter1545"
] | Insulin lispro | Pseudoephedrine | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
1179,
24,
1445
]
],
[
[
1179,
24,
73
],
[
73,
24,
1445
]
],
[
[
1179,
24,
280
],
[
280,
40,
1445
]
],
[
[
1179,
23,
1203
],
[
1203,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Mephen... |
DB00682 | DB01065 | 126 | 43 | [
"DDInter1951",
"DDInter1142"
] | Warfarin | Melatonin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice g... | Moderate | 1 | [
[
[
126,
24,
43
]
],
[
[
126,
64,
598
],
[
598,
1,
43
]
],
[
[
126,
6,
6017
],
[
6017,
45,
43
]
],
[
[
126,
7,
2384
],
[
2384,
46,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melatonin"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nabumetone"
],
[
"Nabumetone",
... | Warfarin may lead to a major life threatening interaction when taken with Nabumetone and Nabumetone (Compound) resembles Melatonin (Compound)
Warfarin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Melatonin (Compound)
Warfarin (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Melatonin... |
DB01261 | DB04575 | 170 | 35 | [
"DDInter1679",
"DDInter1555"
] | Sitagliptin | Quinestrol | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
170,
24,
35
]
],
[
[
170,
24,
890
],
[
890,
1,
35
]
],
[
[
170,
63,
566
],
[
566,
1,
35
]
],
[
[
170,
24,
984
],
[
984,
40,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
],
[
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Quinestrol (Co... |
DB01023 | DB09036 | 409 | 812 | [
"DDInter716",
"DDInter1668"
] | Felodipine | Siltuximab | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
409,
24,
812
]
],
[
[
409,
24,
792
],
[
792,
24,
812
]
],
[
[
409,
62,
1031
],
[
1031,
24,
812
]
],
[
[
409,
1,
1081
],
[
1081,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
],
[
... | Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab
Felodipine may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theo... |
DB00745 | DB01218 | 307 | 1,493 | [
"DDInter1236",
"DDInter852"
] | Modafinil | Halofantrine | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Minor | 0 | [
[
[
307,
23,
1493
]
],
[
[
307,
6,
8374
],
[
8374,
45,
1493
]
],
[
[
307,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
307,
25,
1017
],
[
1017,... | [
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Halofantrine"
]
],
[
[
"Modafinil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Modafinil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halofantrine (Compound)
Modafinil (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Modafinil may lead to a major life threatening interaction when taken with Lorlatini... |
DB00983 | DB01210 | 480 | 668 | [
"DDInter776",
"DDInter1050"
] | Formoterol | Levobunolol (ophthalmic) | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Major | 2 | [
[
[
480,
25,
668
]
],
[
[
480,
64,
461
],
[
461,
1,
668
]
],
[
[
480,
24,
688
],
[
688,
25,
668
]
],
[
[
480,
25,
729
],
[
729,
1,
... | [
[
[
"Formoterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levobunolol"
]
],
[
[
"Formoterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Timolol"
],
[
"Timolol",
"{u} (Compo... | Formoterol may lead to a major life threatening interaction when taken with Levobunolol
Formoterol may lead to a major life threatening interaction when taken with Timolol and Timolol (Compound) resembles Levobunolol (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB05239 | DB14975 | 866 | 988 | [
"DDInter425",
"DDInter1949"
] | Cobimetinib | Voxelotor | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Major | 2 | [
[
[
866,
25,
988
]
],
[
[
866,
24,
1362
],
[
1362,
24,
988
]
],
[
[
866,
25,
676
],
[
676,
63,
988
]
],
[
[
866,
63,
1424
],
[
1424,
... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voxelotor"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
"Olaparib",
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Voxelotor
Cobimetinib may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause... |
DB00252 | DB00317 | 362 | 883 | [
"DDInter1460",
"DDInter810"
] | Phenytoin | Gefitinib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Moderate | 1 | [
[
[
362,
24,
883
]
],
[
[
362,
25,
594
],
[
594,
40,
883
]
],
[
[
362,
24,
1195
],
[
1195,
1,
883
]
],
[
[
362,
6,
1829
],
[
1829,
4... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
],
[
"Bosutinib",
... | Phenytoin may lead to a major life threatening interaction when taken with Bosutinib and Bosutinib (Compound) resembles Gefitinib (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Gefitinib (Compound)
Phenytoin (Compound) bi... |
DB00570 | DB00776 | 147 | 1,335 | [
"DDInter1936",
"DDInter1360"
] | Vinblastine | Oxcarbazepine | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
147,
24,
1335
]
],
[
[
147,
63,
1236
],
[
1236,
1,
1335
]
],
[
[
147,
23,
307
],
[
307,
1,
1335
]
],
[
[
147,
6,
8374
],
[
8374,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Oxcarbazepine (Compound)
Vinblastine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Oxcarbazepine (... |
DB04868 | DB08826 | 478 | 1,292 | [
"DDInter1293",
"DDInter489"
] | Nilotinib | Deferiprone | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
478,
25,
1292
]
],
[
[
478,
21,
28759
],
[
28759,
60,
1292
]
],
[
[
478,
24,
1017
],
[
1017,
63,
1292
]
],
[
[
478,
63,
1512
],
[
1512... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Nilotinib",
"{u} (Compound) causes {v} (Side Effect)",
"Connective tissue disorder"
],
[
"Connective tissue disorder",
"{u} (Si... | Nilotinib (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Deferiprone (Compound)
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate... |
DB00791 | DB10315 | 132 | 1,137 | [
"DDInter1902",
"DDInter1127"
] | Uracil mustard | Measles virus vaccine live attenuated | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
132,
25,
1137
]
],
[
[
132,
64,
581
],
[
581,
25,
1137
]
],
[
[
132,
24,
384
],
[
384,
25,
1137
]
],
[
[
132,
63,
1184
],
[
1184,
... | [
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
... | Uracil mustard may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and I... |
DB00238 | DB06335 | 188 | 761 | [
"DDInter1285",
"DDInter1646"
] | Nevirapine | Saxagliptin | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
188,
24,
761
]
],
[
[
188,
6,
7524
],
[
7524,
45,
761
]
],
[
[
188,
21,
28722
],
[
28722,
60,
761
]
],
[
[
188,
24,
1491
],
[
1491,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)"... | Nevirapine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Saxagliptin (Compound)
Nevirapine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midosta... |
DB00526 | DB04845 | 1,555 | 309 | [
"DDInter1355",
"DDInter1001"
] | Oxaliplatin | Ixabepilone | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1555,
24,
309
]
],
[
[
1555,
24,
60
],
[
60,
23,
309
]
],
[
[
1555,
24,
1419
],
[
1419,
24,
309
]
],
[
[
1555,
63,
139
],
[
139,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Ixabepilone
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Ima... |
DB06779 | DB09075 | 365 | 498 | [
"DDInter470",
"DDInter621"
] | Dalteparin | Edoxaban | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
365,
25,
498
]
],
[
[
365,
23,
944
],
[
944,
62,
498
]
],
[
[
365,
24,
1004
],
[
1004,
63,
498
]
],
[
[
365,
24,
41
],
[
41,
24,... | [
[
[
"Dalteparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Dalteparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Dalteparin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl ... |
DB01050 | DB01099 | 848 | 1,272 | [
"DDInter900",
"DDInter744"
] | Ibuprofen | Flucytosine | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
848,
24,
1272
]
],
[
[
848,
21,
29501
],
[
29501,
60,
1272
]
],
[
[
848,
63,
311
],
[
311,
24,
1272
]
],
[
[
848,
24,
1448
],
[
1448,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Ibuprofen",
"{u} (Compound) causes {v} (Side Effect)",
"Hepatic necrosis"
],
[
"Hepatic necrosis",
"{u} (Side Ef... | Ibuprofen (Compound) causes Hepatic necrosis (Side Effect) and Hepatic necrosis (Side Effect) is caused by Flucytosine (Compound)
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib and Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken... |
DB00280 | DB06788 | 494 | 1,616 | [
"DDInter575",
"DDInter864"
] | Disopyramide | Histrelin | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
494,
25,
1616
]
],
[
[
494,
23,
112
],
[
112,
23,
1616
]
],
[
[
494,
25,
1342
],
[
1342,
24,
1616
]
],
[
[
494,
63,
1179
],
[
1179,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Disopyramide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Disopyramide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Disopyramide may lead to a major life threatening interaction when taken with Romidepsin and Romidepsin may c... |
DB00294 | DB00400 | 1,336 | 353 | [
"DDInter701",
"DDInter843"
] | Etonogestrel | Griseofulvin | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Major | 2 | [
[
[
1336,
25,
353
]
],
[
[
1336,
6,
8374
],
[
8374,
45,
353
]
],
[
[
1336,
21,
28745
],
[
28745,
60,
353
]
],
[
[
1336,
25,
1101
],
[
1101... | [
[
[
"Etonogestrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Griseofulvin"
]
],
[
[
"Etonogestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"G... | Etonogestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Griseofulvin (Compound)
Etonogestrel (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Griseofulvin (Compound)
Etonogestrel may lead to a major life threatening interaction when taken with ... |
DB00501 | DB00557 | 752 | 252 | [
"DDInter380",
"DDInter895"
] | Cimetidine | Hydroxyzine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Minor | 0 | [
[
[
752,
23,
252
]
],
[
[
752,
23,
623
],
[
623,
40,
252
]
],
[
[
752,
6,
12523
],
[
12523,
45,
252
]
],
[
[
752,
21,
28705
],
[
28705,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroxyzine"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Quetiapine"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Quetiapine and Quetiapine (Compound) resembles Hydroxyzine (Compound)
Cimetidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxyzine (Compound)
Cimetidine (Compound) causes Drowsiness (Side Effect) and Drowsine... |
DB00472 | DB08899 | 758 | 129 | [
"DDInter758",
"DDInter649"
] | Fluoxetine | Enzalutamide | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
758,
24,
129
]
],
[
[
758,
24,
918
],
[
918,
1,
129
]
],
[
[
758,
6,
8374
],
[
8374,
45,
129
]
],
[
[
758,
21,
28703
],
[
28703,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Fluoxetine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Fluoxetine (Compound) causes Pruritus (Side Effect) and Pr... |
DB00804 | DB00902 | 1,507 | 104 | [
"DDInter543",
"DDInter1168"
] | Dicyclomine | Methdilazine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1507,
24,
104
]
],
[
[
1507,
63,
13
],
[
13,
24,
104
]
],
[
[
1507,
24,
820
],
[
820,
1,
104
]
],
[
[
1507,
24,
537
],
[
537,
40... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazi... |
DB00983 | DB08882 | 480 | 1,281 | [
"DDInter776",
"DDInter1070"
] | Formoterol | Linagliptin | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
480,
24,
1281
]
],
[
[
480,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
480,
21,
28966
],
[
28966,
60,
1281
]
],
[
[
480,
24,
1529
],
[
1529,... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Formoterol (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Linagliptin (Comp... |
DB00277 | DB01211 | 1,031 | 609 | [
"DDInter1791",
"DDInter393"
] | Theophylline | Clarithromycin | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1031,
24,
609
]
],
[
[
1031,
63,
1570
],
[
1570,
24,
609
]
],
[
[
1031,
6,
16436
],
[
16436,
45,
609
]
],
[
[
1031,
7,
5415
],
[
5415,... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
]... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Theophylline (Compound) binds SLC22A7 (Gene) and SLC22A7 (Gene) is bound by Clarithromycin (Compound)
... |
DB01105 | DB08907 | 222 | 1,344 | [
"DDInter1665",
"DDInter280"
] | Sibutramine | Canagliflozin | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
222,
24,
1344
]
],
[
[
222,
24,
549
],
[
549,
1,
1344
]
],
[
[
222,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
222,
21,
28962
],
[
28962,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Sibutramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Sibutramine (Compound) causes Hyperkalaemia (Side Ef... |
DB00285 | DB06595 | 1,100 | 1,491 | [
"DDInter1927",
"DDInter1214"
] | Venlafaxine | Midostaurin | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1100,
24,
1491
]
],
[
[
1100,
23,
112
],
[
112,
23,
1491
]
],
[
[
1100,
24,
888
],
[
888,
24,
1491
]
],
[
[
1100,
24,
1017
],
[
1017,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Venlafaxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Venlafaxine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Ta... |
DB00081 | DB05679 | 273 | 1,683 | [
"DDInter1838",
"DDInter1907"
] | Tositumomab | Ustekinumab | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
273,
24,
1683
]
],
[
[
273,
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],
[
1362,
63,
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]
],
[
[
273,
25,
792
],
[
792,
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]
],
[
[
273,
64,
1172
],
[
1172,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Tositumomab may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause... |
DB00431 | DB00726 | 1,503 | 1,164 | [
"DDInter1072",
"DDInter1876"
] | Lindane | Trimipramine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
1503,
24,
1164
]
],
[
[
1503,
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],
[
1237,
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[
[
1503,
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],
[
508,
40,
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],
[
[
1503,
21,
28787
],
[
287... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Trimipramine (Compound)
... |
DB00934 | DB01168 | 413 | 1,053 | [
"DDInter1124",
"DDInter1526"
] | Maprotiline | Procarbazine | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
413,
25,
1053
]
],
[
[
413,
18,
4930
],
[
4930,
57,
1053
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],
[
[
413,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
413,
24,
480
],
[
480,
... | [
[
[
"Maprotiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Maprotiline",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Maprotiline (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Maprotiline (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Form... |
DB00988 | DB13928 | 817 | 1,385 | [
"DDInter584",
"DDInter1660"
] | Dopamine | Semaglutide | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
817,
24,
1385
]
],
[
[
817,
63,
73
],
[
73,
24,
1385
]
],
[
[
817,
24,
1148
],
[
1148,
24,
1385
]
],
[
[
817,
40,
532
],
[
532,
... | [
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
],
[
... | Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isopr... |
DB00581 | DB08899 | 355 | 129 | [
"DDInter1018",
"DDInter649"
] | Lactulose | Enzalutamide | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
355,
24,
129
]
],
[
[
355,
24,
918
],
[
918,
1,
129
]
],
[
[
355,
21,
28809
],
[
28809,
60,
129
]
],
[
[
355,
24,
230
],
[
230,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Lactulose (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Enzalutamide (Compound)
Lactulose may cause a moderate interac... |
DB00916 | DB06288 | 112 | 607 | [
"DDInter1202",
"DDInter77"
] | Metronidazole | Amisulpride | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Minor | 0 | [
[
[
112,
23,
607
]
],
[
[
112,
21,
29232
],
[
29232,
60,
607
]
],
[
[
112,
23,
1559
],
[
1559,
24,
607
]
],
[
[
112,
63,
589
],
[
589,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amisulpride"
]
],
[
[
"Metronidazole",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect) is... | Metronidazole (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Amisulpride (Compound)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Famotidine and Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Am... |
DB00759 | DB09146 | 1,620 | 489 | [
"DDInter1783",
"DDInter978"
] | Tetracycline | Iron sucrose | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
1620,
24,
489
]
],
[
[
1620,
24,
260
],
[
260,
63,
489
]
],
[
[
1620,
1,
1669
],
[
1669,
24,
489
]
],
[
[
1620,
24,
954
],
[
954,
... | [
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhyd... | Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Ferrous sulfate anhydrous and Ferrous sulfate anhydrous may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Tetracycline (Compound) resembles Minocycline (Compound) and Minocycline may c... |
DB00647 | DB12141 | 675 | 971 | [
"DDInter528",
"DDInter817"
] | Dextropropoxyphene | Gilteritinib | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
675,
24,
971
]
],
[
[
675,
23,
112
],
[
112,
23,
971
]
],
[
[
675,
24,
485
],
[
485,
24,
971
]
],
[
[
675,
24,
823
],
[
823,
63,... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazo... | Dextropropoxyphene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with P... |
DB00526 | DB00816 | 1,555 | 1,674 | [
"DDInter1355",
"DDInter1346"
] | Oxaliplatin | Orciprenaline | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
1555,
24,
1674
]
],
[
[
1555,
24,
1164
],
[
1164,
24,
1674
]
],
[
[
1555,
63,
534
],
[
534,
24,
1674
]
],
[
[
1555,
24,
484
],
[
484,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Tramadol and... |
DB00348 | DB14723 | 254 | 159 | [
"DDInter1300",
"DDInter1026"
] | Nitisinone | Larotrectinib | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
254,
24,
159
]
],
[
[
254,
24,
1375
],
[
1375,
24,
159
]
],
[
[
254,
23,
307
],
[
307,
24,
159
]
],
[
[
254,
63,
529
],
[
529,
2... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Nitisinone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafini... |
DB00726 | DB12267 | 1,164 | 1,476 | [
"DDInter1876",
"DDInter233"
] | Trimipramine | Brigatinib | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1164,
24,
1476
]
],
[
[
1164,
24,
918
],
[
918,
24,
1476
]
],
[
[
1164,
63,
79
],
[
79,
24,
1476
]
],
[
[
1164,
25,
1133
],
[
1133,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and... |
DB00531 | DB15982 | 450 | 1,339 | [
"DDInter456",
"DDInter193"
] | Cyclophosphamide | Berotralstat | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
450,
24,
1339
]
],
[
[
450,
24,
351
],
[
351,
24,
1339
]
],
[
[
450,
63,
134
],
[
134,
24,
1339
]
],
[
[
450,
25,
676
],
[
676,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Berotralstat
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Vinorel... |
DB01050 | DB11095 | 848 | 235 | [
"DDInter900",
"DDInter505"
] | Ibuprofen | Desirudin | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
848,
25,
235
]
],
[
[
848,
23,
297
],
[
297,
23,
235
]
],
[
[
848,
63,
1100
],
[
1100,
24,
235
]
],
[
[
848,
24,
643
],
[
643,
2... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Ibuprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} m... | Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause ... |
DB01001 | DB14509 | 688 | 1,399 | [
"DDInter1632",
"DDInter1081"
] | Salbutamol | Lithium carbonate | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
688,
24,
1399
]
],
[
[
688,
63,
874
],
[
874,
23,
1399
]
],
[
[
688,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
688,
63,
1010
],
[
1010,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide an... |
DB00622 | DB09333 | 1,081 | 278 | [
"DDInter1287",
"DDInter963"
] | Nicardipine | Iopodic acid | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a radiopaque property. It was devel... | Moderate | 1 | [
[
[
1081,
24,
278
]
],
[
[
1081,
40,
84
],
[
84,
24,
278
]
],
[
[
1081,
63,
1648
],
[
1648,
24,
278
]
],
[
[
1081,
24,
1527
],
[
1527,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
]
],
[
[
"Nicardipine",
"{u} (Compound) resembles {v} (Compound)",
"Nisoldipine"
],
[
"Nisoldipine",
"{u} may cause a m... | Nicardipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction th... |
DB01175 | DB11703 | 318 | 405 | [
"DDInter672",
"DDInter9"
] | Escitalopram | Acalabrutinib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
318,
24,
405
]
],
[
[
318,
23,
951
],
[
951,
24,
405
]
],
[
[
318,
25,
982
],
[
982,
63,
405
]
],
[
[
318,
40,
1230
],
[
1230,
2... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Escitalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Palbociclib"
],
... | Escitalopram may cause a minor interaction that can limit clinical effects when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Escitalopram may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may... |
DB00357 | DB15233 | 1,051 | 1,650 | [
"DDInter71",
"DDInter142"
] | Aminoglutethimide | Avapritinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
1051,
24,
1650
]
],
[
[
1051,
24,
1478
],
[
1478,
24,
1650
]
],
[
[
1051,
62,
1101
],
[
1101,
24,
1650
]
],
[
[
1051,
24,
1409
],
[
14... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Bexarotene... |
DB06674 | DB12332 | 908 | 1,619 | [
"DDInter837",
"DDInter1626"
] | Golimumab | Rucaparib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
908,
25,
1619
]
],
[
[
908,
63,
112
],
[
112,
23,
1619
]
],
[
[
908,
64,
259
],
[
259,
24,
1619
]
],
[
[
908,
24,
151
],
[
151,
... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Golimumab may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause... |
DB00844 | DB01041 | 314 | 770 | [
"DDInter1257",
"DDInter1789"
] | Nalbuphine | Thalidomide | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
314,
24,
770
]
],
[
[
314,
7,
4830
],
[
4830,
46,
770
]
],
[
[
314,
18,
9384
],
[
9384,
57,
770
]
],
[
[
314,
21,
28789
],
[
28789,
... | [
[
[
"Nalbuphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Nalbuphine",
"{u} (Compound) upregulates {v} (Gene)",
"TGFBR2"
],
[
"TGFBR2",
"{u} (Gene) is upregulated by {v}... | Nalbuphine (Compound) upregulates TGFBR2 (Gene) and TGFBR2 (Gene) is upregulated by Thalidomide (Compound)
Nalbuphine (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Thalidomide (Compound)
Nalbuphine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect)... |
DB01320 | DB08904 | 651 | 375 | [
"DDInter783",
"DDInter342"
] | Fosphenytoin | Certolizumab pegol | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
651,
24,
375
]
],
[
[
651,
25,
1593
],
[
1593,
24,
375
]
],
[
[
651,
63,
303
],
[
303,
24,
375
]
],
[
[
651,
62,
608
],
[
608,
2... | [
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
... | Fosphenytoin may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acet... |
DB01110 | DB01218 | 86 | 1,493 | [
"DDInter1209",
"DDInter852"
] | Miconazole | Halofantrine | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Moderate | 1 | [
[
[
86,
24,
1493
]
],
[
[
86,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
86,
18,
2183
],
[
2183,
57,
1493
]
],
[
[
86,
21,
28810
],
[
28810,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halofantrine"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Miconazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Miconazole (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Halofantrine (Compound)
Miconazole (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused... |
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