drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00204 | DB14723 | 228 | 159 | [
"DDInter580",
"DDInter1026"
] | Dofetilide | Larotrectinib | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
228,
24,
159
]
],
[
[
228,
24,
98
],
[
98,
24,
159
]
],
[
[
228,
25,
1181
],
[
1181,
24,
159
]
],
[
[
228,
23,
1220
],
[
1220,
2... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
[
... | Dofetilide may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Dofetilide may lead to a major life threatening interaction when taken with Terfenadine and Terfenadine may cause... |
DB00030 | DB11921 | 1,685 | 1,019 | [
"DDInter934",
"DDInter492"
] | Insulin human | Deflazacort | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1685,
24,
1019
]
],
[
[
1685,
24,
1072
],
[
1072,
23,
1019
]
],
[
[
1685,
24,
192
],
[
192,
24,
1019
]
],
[
[
1685,
24,
1654
],
[
1654... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Esterified estroge... |
DB01045 | DB06228 | 463 | 792 | [
"DDInter1590",
"DDInter1609"
] | Rifampicin | Rivaroxaban | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
463,
25,
792
]
],
[
[
463,
6,
4973
],
[
4973,
45,
792
]
],
[
[
463,
63,
79
],
[
79,
24,
792
]
],
[
[
463,
25,
466
],
[
466,
63,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Rifampicin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Rivaroxa... | Rifampicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Rifampicin may lead ... |
DB01138 | DB05578 | 804 | 330 | [
"DDInter1726",
"DDInter1566"
] | Sulfinpyrazone | Ramucirumab | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
804,
25,
330
]
],
[
[
804,
24,
384
],
[
384,
63,
330
]
],
[
[
804,
24,
557
],
[
557,
24,
330
]
],
[
[
804,
63,
222
],
[
222,
24,... | [
[
[
"Sulfinpyrazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
"I... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic ... |
DB06228 | DB14357 | 792 | 944 | [
"DDInter1609",
"DDInter347"
] | Rivaroxaban | Chamomile | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
792,
23,
944
]
],
[
[
792,
64,
256
],
[
256,
23,
944
]
],
[
[
792,
25,
498
],
[
498,
23,
944
]
],
[
[
792,
64,
256
],
[
256,
64,... | [
[
[
"Rivaroxaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Rivaroxaban may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Rivaroxaban may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a minor interaction th... |
DB00857 | DB08903 | 1,387 | 996 | [
"DDInter1768",
"DDInter170"
] | Terbinafine | Bedaquiline | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
1387,
24,
996
]
],
[
[
1387,
1,
11247
],
[
11247,
1,
996
]
],
[
[
1387,
40,
11325
],
[
11325,
1,
996
]
],
[
[
1387,
6,
8374
],
[
8374,... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Terbinafine",
"{u} (Compound) resembles {v} (Compound)",
"Naftifine"
],
[
"Naftifine",
"{u} (Compound) resembl... | Terbinafine (Compound) resembles Naftifine (Compound) and Naftifine (Compound) resembles Bedaquiline (Compound)
Terbinafine (Compound) resembles Butenafine (Compound) and Butenafine (Compound) resembles Bedaquiline (Compound)
Terbinafine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound... |
DB00570 | DB00872 | 147 | 1,080 | [
"DDInter1936",
"DDInter438"
] | Vinblastine | Conivaptan | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Major | 2 | [
[
[
147,
25,
1080
]
],
[
[
147,
24,
165
],
[
165,
40,
1080
]
],
[
[
147,
6,
8374
],
[
8374,
45,
1080
]
],
[
[
147,
21,
28769
],
[
28769,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
],
[
"Tolvaptan... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvaptan (Compound) resembles Conivaptan (Compound)
Vinblastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Conivaptan (Compound)
Vinblastine (Compound) causes Feeling abnormal (Side Effect) and F... |
DB00580 | DB12332 | 311 | 1,619 | [
"DDInter1910",
"DDInter1626"
] | Valdecoxib | Rucaparib | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
311,
24,
1619
]
],
[
[
311,
24,
112
],
[
112,
23,
1619
]
],
[
[
311,
24,
1662
],
[
1662,
24,
1619
]
],
[
[
311,
24,
159
],
[
159,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid ... |
DB00705 | DB06176 | 441 | 1,342 | [
"DDInter496",
"DDInter1616"
] | Delavirdine | Romidepsin | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
441,
24,
1342
]
],
[
[
441,
25,
1491
],
[
1491,
63,
1342
]
],
[
[
441,
63,
51
],
[
51,
24,
1342
]
],
[
[
441,
24,
1619
],
[
1619,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
],
[
"Midosta... | Delavirdine may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin ma... |
DB03619 | DB09030 | 557 | 840 | [
"DDInter501",
"DDInter1945"
] | Deoxycholic acid | Vorapaxar | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Moderate | 1 | [
[
[
557,
24,
840
]
],
[
[
557,
63,
885
],
[
885,
24,
840
]
],
[
[
557,
24,
1496
],
[
1496,
63,
840
]
],
[
[
557,
24,
578
],
[
578,
2... | [
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorapaxar"
]
],
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
... | Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Ninted... |
DB01577 | DB09104 | 1,529 | 286 | [
"DDInter1161",
"DDInter1118"
] | Metamfetamine | Magnesium hydroxide | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1529,
24,
286
]
],
[
[
1529,
63,
820
],
[
820,
23,
286
]
],
[
[
1529,
1,
633
],
[
633,
24,
286
]
],
[
[
1529,
63,
688
],
[
688,
... | [
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"... | Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Metamfetamine (Compound) resembles Lisdexamfetamine (Compound) and Lisdexamfetamine may cause a mode... |
DB01041 | DB06168 | 770 | 1,531 | [
"DDInter1789",
"DDInter281"
] | Thalidomide | Canakinumab | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
770,
24,
1531
]
],
[
[
770,
63,
523
],
[
523,
24,
1531
]
],
[
[
770,
64,
377
],
[
377,
24,
1531
]
],
[
[
770,
24,
1270
],
[
1270,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Thalidomide may lead to a major life threatening interaction when taken with Mitomycin and Mitomycin may cause... |
DB01403 | DB09291 | 9 | 741 | [
"DDInter1175",
"DDInter1615"
] | Methotrimeprazine | Rolapitant | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
9,
24,
741
]
],
[
[
9,
64,
506
],
[
506,
24,
741
]
],
[
[
9,
40,
1164
],
[
1164,
24,
741
]
],
[
[
9,
63,
1264
],
[
1264,
24,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Methotrimeprazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextromethorphan"
],
... | Methotrimeprazine may lead to a major life threatening interaction when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Methotrimeprazine (Compound) resembles Trimipramine (Compound) and Trimipramine may cause a moderate interac... |
DB00307 | DB09330 | 1,101 | 985 | [
"DDInter202",
"DDInter1352"
] | Bexarotene | Osimertinib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1101,
24,
985
]
],
[
[
1101,
62,
168
],
[
168,
23,
985
]
],
[
[
1101,
24,
1478
],
[
1478,
24,
985
]
],
[
[
1101,
63,
66
],
[
66,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor ... |
DB08865 | DB08895 | 1,593 | 976 | [
"DDInter448",
"DDInter1825"
] | Crizotinib | Tofacitinib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
1593,
24,
976
]
],
[
[
1593,
62,
307
],
[
307,
23,
976
]
],
[
[
1593,
24,
214
],
[
214,
63,
976
]
],
[
[
1593,
25,
982
],
[
982,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Crizotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Crizotinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamati... |
DB00991 | DB01249 | 97 | 258 | [
"DDInter1358",
"DDInter958"
] | Oxaprozin | Iodixanol | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
97,
25,
258
]
],
[
[
97,
25,
497
],
[
497,
1,
258
]
],
[
[
97,
21,
28748
],
[
28748,
60,
258
]
],
[
[
97,
24,
712
],
[
712,
64,
... | [
[
[
"Oxaprozin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Oxaprozin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u} (Compound)... | Oxaprozin may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Oxaprozin (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Oxaprozin may cause a moderate interaction that could exacerbate diseases... |
DB00812 | DB04868 | 998 | 478 | [
"DDInter1451",
"DDInter1293"
] | Phenylbutazone | Nilotinib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
998,
24,
478
]
],
[
[
998,
25,
1468
],
[
1468,
63,
478
]
],
[
[
998,
6,
6017
],
[
6017,
45,
478
]
],
[
[
998,
18,
5660
],
[
5660,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Pona... | Phenylbutazone may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Phenylbutazone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Phenylbutazone (Compound) dow... |
DB00023 | DB01097 | 305 | 1,377 | [
"DDInter127",
"DDInter1033"
] | Asparaginase Escherichia coli | Leflunomide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
305,
25,
1377
]
],
[
[
305,
24,
949
],
[
949,
63,
1377
]
],
[
[
305,
24,
126
],
[
126,
24,
1377
]
],
[
[
305,
24,
1622
],
[
1622,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clo... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Lefl... |
DB00834 | DB09049 | 932 | 1,135 | [
"DDInter1215",
"DDInter1261"
] | Mifepristone | Naloxegol | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Major | 2 | [
[
[
932,
25,
1135
]
],
[
[
932,
25,
1406
],
[
1406,
62,
1135
]
],
[
[
932,
64,
1424
],
[
1424,
23,
1135
]
],
[
[
932,
25,
1069
],
[
1069,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
]
],
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
],
[
"Neratinib",
"{u} ... | Mifepristone may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Mifepristone may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a minor interaction th... |
DB09080 | DB14568 | 144 | 982 | [
"DDInter1331",
"DDInter1000"
] | Olodaterol | Ivosidenib | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
144,
24,
982
]
],
[
[
144,
62,
1247
],
[
1247,
23,
982
]
],
[
[
144,
63,
543
],
[
543,
24,
982
]
],
[
[
144,
24,
1032
],
[
1032,
... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Olodaterol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Olodaterol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Loperamide an... |
DB00270 | DB08904 | 1,428 | 375 | [
"DDInter993",
"DDInter342"
] | Isradipine | Certolizumab pegol | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
1428,
24,
375
]
],
[
[
1428,
24,
1593
],
[
1593,
24,
375
]
],
[
[
1428,
1,
409
],
[
409,
24,
375
]
],
[
[
1428,
23,
467
],
[
467,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Isradipine (Compound) resembles Felodipine (Compound) and Felodipine may cause a moderate interaction th... |
DB00328 | DB00712 | 831 | 1,274 | [
"DDInter921",
"DDInter763"
] | Indomethacin | Flurbiprofen | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
831,
24,
1274
]
],
[
[
831,
40,
734
],
[
734,
1,
1274
]
],
[
[
831,
6,
15705
],
[
15705,
45,
1274
]
],
[
[
831,
10,
11666
],
[
11666,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Indomethacin",
"{u} (Compound) resembles {v} (Compound)",
"Naproxen"
],
[
"Naproxen",
"{u} (Compound) resemb... | Indomethacin (Compound) resembles Naproxen (Compound) and Naproxen (Compound) resembles Flurbiprofen (Compound)
Indomethacin (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Flurbiprofen (Compound)
Indomethacin (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Flurbi... |
DB09061 | DB09079 | 1,627 | 1,496 | [
"DDInter284",
"DDInter1296"
] | Cannabidiol | Nintedanib | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
1627,
24,
1496
]
],
[
[
1627,
62,
609
],
[
609,
24,
1496
]
],
[
[
1627,
63,
267
],
[
267,
24,
1496
]
],
[
[
1627,
24,
913
],
[
913,
... | [
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Cannabidiol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
],
... | Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone an... |
DB01166 | DB05316 | 477 | 749 | [
"DDInter379",
"DDInter1467"
] | Cilostazol | Pimavanserin | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Moderate | 1 | [
[
[
477,
24,
749
]
],
[
[
477,
62,
112
],
[
112,
23,
749
]
],
[
[
477,
63,
522
],
[
522,
24,
749
]
],
[
[
477,
24,
392
],
[
392,
24,... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimavanserin"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimavanserin
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Z... |
DB00604 | DB00986 | 1,425 | 1,192 | [
"DDInter385",
"DDInter834"
] | Cisapride | Glycopyrronium | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
1425,
24,
1192
]
],
[
[
1425,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
1425,
24,
262
],
[
262,
24,
1192
]
],
[
[
1425,
25,
504
],
[
504,
... | [
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[... | Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Cli... |
DB00384 | DB01075 | 1,275 | 1,376 | [
"DDInter1859",
"DDInter569"
] | Triamterene | Diphenhydramine | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1275,
24,
1376
]
],
[
[
1275,
24,
401
],
[
401,
24,
1376
]
],
[
[
1275,
6,
7950
],
[
7950,
45,
1376
]
],
[
[
1275,
21,
28921
],
[
2892... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Triamterene (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Diphenhydramine (Compound)
Tr... |
DB01576 | DB09154 | 93 | 1,475 | [
"DDInter526",
"DDInter1686"
] | Dextroamphetamine | Sodium citrate | Dextroamphetamine is the dextrorotatory enantiomer of amphetamine. Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder[L6010,Label]. | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Moderate | 1 | [
[
[
93,
24,
1475
]
],
[
[
93,
63,
22
],
[
22,
24,
1475
]
],
[
[
93,
1,
1529
],
[
1529,
24,
1475
]
],
[
[
93,
74,
1445
],
[
1445,
24,... | [
[
[
"Dextroamphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium citrate"
]
],
[
[
"Dextroamphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine... | Dextroamphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Sodium citrate
Dextroamphetamine (Compound) resembles Metamfetamine (Compound) and Metamfetamine may cause a moderate ... |
DB00390 | DB00712 | 1,252 | 1,274 | [
"DDInter554",
"DDInter763"
] | Digoxin | Flurbiprofen | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
1252,
24,
1274
]
],
[
[
1252,
7,
7720
],
[
7720,
45,
1274
]
],
[
[
1252,
7,
7448
],
[
7448,
46,
1274
]
],
[
[
1252,
7,
7623
],
[
7623,... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Digoxin",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Compound)",... | Digoxin (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Flurbiprofen (Compound)
Digoxin (Compound) upregulates MOK (Gene) and MOK (Gene) is upregulated by Flurbiprofen (Compound)
Digoxin (Compound) upregulates RRP12 (Gene) and RRP12 (Gene) is downregulated by Flurbiprofen (Compound)
Digoxin (Compound) ... |
DB00842 | DB01105 | 686 | 222 | [
"DDInter1359",
"DDInter1665"
] | Oxazepam | Sibutramine | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
686,
24,
222
]
],
[
[
686,
6,
8374
],
[
8374,
45,
222
]
],
[
[
686,
21,
28852
],
[
28852,
60,
222
]
],
[
[
686,
1,
1563
],
[
1563,
... | [
[
[
"Oxazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Oxazepam",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Oxazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Oxazepam (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutramine (Compound)
Oxazepam (Compound) resembles Halazepam (Compound) and Halazepam may cause a moderate interaction that could e... |
DB00030 | DB00472 | 1,685 | 758 | [
"DDInter934",
"DDInter758"
] | Insulin human | Fluoxetine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
1685,
24,
758
]
],
[
[
1685,
24,
542
],
[
542,
23,
758
]
],
[
[
1685,
24,
1148
],
[
1148,
63,
758
]
],
[
[
1685,
24,
245
],
[
245,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
],... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Fluoxetine
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Isoprenalin... |
DB08895 | DB15233 | 976 | 1,650 | [
"DDInter1825",
"DDInter142"
] | Tofacitinib | Avapritinib | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
976,
25,
1650
]
],
[
[
976,
64,
1101
],
[
1101,
24,
1650
]
],
[
[
976,
24,
159
],
[
159,
24,
1650
]
],
[
[
976,
25,
270
],
[
270,
... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
"{u... | Tofacitinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib m... |
DB00317 | DB06636 | 883 | 1,623 | [
"DDInter810",
"DDInter980"
] | Gefitinib | Isavuconazonium | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
883,
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[
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883,
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[
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883,
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[
1195,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizoti... |
DB00008 | DB09570 | 491 | 1,480 | [
"DDInter1407",
"DDInter1002"
] | Peginterferon alfa-2a | Ixazomib | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
491,
24,
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[
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],
[
440,
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],
[
148,
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]
],
[
[
491,
25,
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],
[
1477,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Filgras... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim and Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB06603 | DB08826 | 39 | 1,292 | [
"DDInter1387",
"DDInter489"
] | Panobinostat | Deferiprone | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
39,
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]
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[
[
39,
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[
1512,
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],
[
[
39,
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],
[
482,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
"Lorla... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Panobinostat may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may c... |
DB00501 | DB08893 | 752 | 271 | [
"DDInter380",
"DDInter1229"
] | Cimetidine | Mirabegron | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significa... | Minor | 0 | [
[
[
752,
23,
271
]
],
[
[
752,
24,
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],
[
371,
40,
271
]
],
[
[
752,
6,
4973
],
[
4973,
45,
271
]
],
[
[
752,
21,
29293
],
[
29293,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) resembles Mirabegron (Compound)
Cimetidine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mirabegron (Compound)
Cimetidine (Compound) causes Leukocytoclastic vasculitis (Side Eff... |
DB01209 | DB11130 | 1,359 | 407 | [
"DDInter531",
"DDInter1344"
] | Dezocine | Opium | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Major | 2 | [
[
[
1359,
25,
407
]
],
[
[
1359,
63,
662
],
[
662,
24,
407
]
],
[
[
1359,
24,
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],
[
976,
24,
407
]
],
[
[
1359,
64,
475
],
[
475,
... | [
[
[
"Dezocine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Opium"
]
],
[
[
"Dezocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
"Carbinoxamine",
... | Dezocine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Dezocine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofaciti... |
DB09276 | DB12834 | 381 | 148 | [
"DDInter1682",
"DDInter1649"
] | Sodium aurothiomalate | Secnidazole | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
381,
24,
148
]
],
[
[
381,
63,
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],
[
1593,
24,
148
]
],
[
[
381,
24,
1480
],
[
1480,
24,
148
]
],
[
[
381,
64,
1487
],
[
1487,
... | [
[
[
"Sodium aurothiomalate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Sodium aurothiomalate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Criz... | Sodium aurothiomalate may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Sodium aurothiomalate may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00196 | DB00661 | 600 | 122 | [
"DDInter743",
"DDInter1928"
] | Fluconazole | Verapamil | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Moderate | 1 | [
[
[
600,
24,
122
]
],
[
[
600,
6,
8374
],
[
8374,
45,
122
]
],
[
[
600,
21,
28809
],
[
28809,
60,
122
]
],
[
[
600,
23,
222
],
[
222,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verapamil"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Verapamil (Compound)
Fluconazole (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Verapamil (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibu... |
DB00524 | DB01168 | 811 | 1,053 | [
"DDInter1199",
"DDInter1526"
] | Metolazone | Procarbazine | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
811,
24,
1053
]
],
[
[
811,
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],
[
848,
40,
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]
],
[
[
811,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
811,
23,
126
],
[
126,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Metolazone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Metolazone may cause a minor interaction tha... |
DB00674 | DB00804 | 1,516 | 1,507 | [
"DDInter802",
"DDInter543"
] | Galantamine | Dicyclomine | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
1516,
24,
1507
]
],
[
[
1516,
21,
29231
],
[
29231,
60,
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]
],
[
[
1516,
63,
1594
],
[
1594,
24,
1507
]
],
[
[
1516,
24,
832
],
[
8... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Galantamine",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
"{u} (Sid... | Galantamine (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Dicyclomine (Compound)
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when t... |
DB00467 | DB01575 | 1,467 | 1,054 | [
"DDInter644",
"DDInter1005"
] | Enoxacin | Kaolin | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
1467,
24,
1054
]
],
[
[
1467,
40,
1176
],
[
1176,
24,
1054
]
],
[
[
1467,
1,
1539
],
[
1539,
24,
1054
]
],
[
[
1467,
40,
1176
],
[
117... | [
[
[
"Enoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Enoxacin",
"{u} (Compound) resembles {v} (Compound)",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} may cause a moderate in... | Enoxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Enoxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Enoxacin (... |
DB00757 | DB11363 | 1,166 | 1,276 | [
"DDInter581",
"DDInter39"
] | Dolasetron | Alectinib | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
1166,
24,
1276
]
],
[
[
1166,
25,
819
],
[
819,
24,
1276
]
],
[
[
1166,
64,
88
],
[
88,
24,
1276
]
],
[
[
1166,
25,
1097
],
[
1097,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acebutolol"
],
[
"Acebutolol"... | Dolasetron may lead to a major life threatening interaction when taken with Acebutolol and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Dolasetron may lead to a major life threatening interaction when taken with Metoprolol and Metoprolol may cause a moderate inter... |
DB01255 | DB12332 | 633 | 1,619 | [
"DDInter1078",
"DDInter1626"
] | Lisdexamfetamine | Rucaparib | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
633,
24,
1619
]
],
[
[
633,
64,
222
],
[
222,
23,
1619
]
],
[
[
633,
62,
112
],
[
112,
23,
1619
]
],
[
[
633,
63,
888
],
[
888,
... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Lisdexamfetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
... | Lisdexamfetamine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronida... |
DB01235 | DB05773 | 1,191 | 1,047 | [
"DDInter1054",
"DDInter1848"
] | Levodopa | Trastuzumab emtansine | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
1191,
24,
1047
]
],
[
[
1191,
24,
375
],
[
375,
63,
1047
]
],
[
[
1191,
63,
458
],
[
458,
24,
1047
]
],
[
[
1191,
24,
1487
],
[
1487,
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol and Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Levodopa may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00220 | DB06176 | 798 | 1,342 | [
"DDInter1276",
"DDInter1616"
] | Nelfinavir | Romidepsin | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
798,
24,
1342
]
],
[
[
798,
25,
1491
],
[
1491,
63,
1342
]
],
[
[
798,
24,
51
],
[
51,
24,
1342
]
],
[
[
798,
24,
1619
],
[
1619,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
],
[
"Midostaur... | Nelfinavir may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may ... |
DB00581 | DB01100 | 355 | 1,568 | [
"DDInter1018",
"DDInter1470"
] | Lactulose | Pimozide | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
355,
24,
1568
]
],
[
[
355,
63,
78
],
[
78,
40,
1568
]
],
[
[
355,
24,
1557
],
[
1557,
25,
1568
]
],
[
[
355,
21,
28809
],
[
28809,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may lead to a major life threatening interactio... |
DB00444 | DB00794 | 63 | 759 | [
"DDInter1765",
"DDInter1521"
] | Teniposide | Primidone | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
63,
24,
759
]
],
[
[
63,
24,
697
],
[
697,
40,
759
]
],
[
[
63,
63,
362
],
[
362,
1,
759
]
],
[
[
63,
6,
6017
],
[
6017,
45,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Compound... |
DB00906 | DB04837 | 1,567 | 649 | [
"DDInter1801",
"DDInter407"
] | Tiagabine | Clofedanol | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1567,
24,
649
]
],
[
[
1567,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1567,
63,
832
],
[
832,
40,
649
]
],
[
[
1567,
63,
701
],
[
701,
... | [
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[... | Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamin... |
DB00491 | DB08886 | 127 | 637 | [
"DDInter1217",
"DDInter126"
] | Miglitol | Asparaginase Erwinia chrysanthemi | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
127,
24,
637
]
],
[
[
127,
24,
167
],
[
167,
24,
637
]
],
[
[
127,
63,
590
],
[
590,
24,
637
]
],
[
[
127,
24,
1296
],
[
1296,
6... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocor... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Miglitol may cause a moderate interaction that could exacerbate diseases when taken... |
DB00491 | DB06663 | 127 | 1,154 | [
"DDInter1217",
"DDInter1398"
] | Miglitol | Pasireotide | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
127,
24,
1154
]
],
[
[
127,
63,
966
],
[
966,
40,
1154
]
],
[
[
127,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
127,
24,
959
],
[
959,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Miglitol (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Miglitol may cause a moderate intera... |
DB01263 | DB14568 | 859 | 982 | [
"DDInter1494",
"DDInter1000"
] | Posaconazole | Ivosidenib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
859,
25,
982
]
],
[
[
859,
62,
112
],
[
112,
23,
982
]
],
[
[
859,
63,
168
],
[
168,
23,
982
]
],
[
[
859,
25,
976
],
[
976,
24,... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Posaconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and ... |
DB00015 | DB00472 | 582 | 758 | [
"DDInter1585",
"DDInter758"
] | Reteplase | Fluoxetine | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
582,
24,
758
]
],
[
[
582,
24,
109
],
[
109,
40,
758
]
],
[
[
582,
25,
802
],
[
802,
63,
758
]
],
[
[
582,
25,
273
],
[
273,
24,... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
[
... | Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compound)
Reteplase may lead to a major life threatening interaction when taken with Tinzaparin and Tinzaparin may cause a moderate interaction that could exacerbate disea... |
DB00365 | DB08881 | 839 | 868 | [
"DDInter842",
"DDInter1925"
] | Grepafloxacin | Vemurafenib | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
839,
25,
868
]
],
[
[
839,
23,
112
],
[
112,
23,
868
]
],
[
[
839,
24,
310
],
[
310,
24,
868
]
],
[
[
839,
24,
286
],
[
286,
63,... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Me... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vemurafenib
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel ... |
DB00574 | DB01001 | 121 | 688 | [
"DDInter717",
"DDInter1632"
] | Fenfluramine | Salbutamol | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
121,
24,
688
]
],
[
[
121,
24,
455
],
[
455,
24,
688
]
],
[
[
121,
24,
1148
],
[
1148,
63,
688
]
],
[
[
121,
25,
827
],
[
827,
2... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and ... |
DB00581 | DB01208 | 355 | 945 | [
"DDInter1018",
"DDInter1705"
] | Lactulose | Sparfloxacin | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Moderate | 1 | [
[
[
355,
24,
945
]
],
[
[
355,
24,
739
],
[
739,
1,
945
]
],
[
[
355,
63,
1176
],
[
1176,
1,
945
]
],
[
[
355,
21,
28810
],
[
28810,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (... |
DB01610 | DB09054 | 248 | 384 | [
"DDInter1912",
"DDInter905"
] | Valganciclovir | Idelalisib | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
248,
24,
384
]
],
[
[
248,
63,
328
],
[
328,
24,
384
]
],
[
[
248,
24,
1468
],
[
1468,
24,
384
]
],
[
[
248,
24,
1619
],
[
1619,
... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Ponat... |
DB01030 | DB01033 | 869 | 328 | [
"DDInter1835",
"DDInter1156"
] | Topotecan | Mercaptopurine | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
869,
24,
328
]
],
[
[
869,
7,
11104
],
[
11104,
45,
328
]
],
[
[
869,
21,
28681
],
[
28681,
60,
328
]
],
[
[
869,
62,
1299
],
[
1299,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Topotecan",
"{u} (Compound) upregulates {v} (Gene)",
"TPMT"
],
[
"TPMT",
"{u} (Gene) is bound by {v} (Compoun... | Topotecan (Compound) upregulates TPMT (Gene) and TPMT (Gene) is bound by Mercaptopurine (Compound)
Topotecan (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Mercaptopurine (Compound)
Topotecan may cause a minor interaction that can limit clinical effects when taken with ... |
DB00655 | DB09045 | 559 | 52 | [
"DDInter682",
"DDInter607"
] | Estrone | Dulaglutide | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
559,
24,
52
]
],
[
[
559,
24,
170
],
[
170,
23,
52
]
],
[
[
559,
24,
609
],
[
609,
24,
52
]
],
[
[
559,
63,
1152
],
[
1152,
24,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
... | Estrone may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Estrone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarith... |
DB01319 | DB11581 | 34 | 1,456 | [
"DDInter777",
"DDInter1926"
] | Fosamprenavir | Venetoclax | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
34,
25,
1456
]
],
[
[
34,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
34,
25,
1476
],
[
1476,
63,
1456
]
],
[
[
34,
23,
466
],
[
466,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{... | Fosamprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Fosamprenavir may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate in... |
DB10276 | DB14724 | 1,624 | 48 | [
"DDInter1623",
"DDInter634"
] | Rotavirus vaccine | Emapalumab | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Major | 2 | [
[
[
1624,
25,
48
]
],
[
[
1624,
64,
713
],
[
713,
24,
48
]
],
[
[
1624,
25,
1456
],
[
1456,
24,
48
]
],
[
[
1624,
64,
713
],
[
713,
... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Emapalumab"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dimethyl fumarate"
],
[
"Dime... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Rotavirus vaccine may lead to a major life threatening interaction when taken with Venetoclax and Venetocl... |
DB00843 | DB00986 | 479 | 1,192 | [
"DDInter583",
"DDInter834"
] | Donepezil | Glycopyrronium | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
479,
24,
1192
]
],
[
[
479,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
479,
63,
262
],
[
262,
24,
1192
]
],
[
[
479,
21,
29180
],
[
29180,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Cli... |
DB00945 | DB06605 | 1,479 | 1,409 | [
"DDInter20",
"DDInter108"
] | Acetylsalicylic acid | Apixaban | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
1479,
25,
1409
]
],
[
[
1479,
6,
3486
],
[
3486,
45,
1409
]
],
[
[
1479,
21,
29666
],
[
29666,
60,
1409
]
],
[
[
1479,
23,
539
],
[
53... | [
[
[
"Acetylsalicylic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Acetylsalicylic acid",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Acetylsalicylic acid (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Apixaban (Compound)
Acetylsalicylic acid (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with... |
DB00022 | DB05528 | 268 | 1,070 | [
"DDInter1408",
"DDInter1228"
] | Peginterferon alfa-2b | Mipomersen | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
268,
25,
1070
]
],
[
[
268,
24,
14
],
[
14,
25,
1070
]
],
[
[
268,
24,
350
],
[
350,
64,
1070
]
],
[
[
268,
25,
593
],
[
593,
25... | [
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
],... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may lead to a major life threatening interaction when taken with Mipomersen
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomi... |
DB00570 | DB09052 | 147 | 250 | [
"DDInter1936",
"DDInter220"
] | Vinblastine | Blinatumomab | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Moderate | 1 | [
[
[
147,
24,
250
]
],
[
[
147,
24,
949
],
[
949,
63,
250
]
],
[
[
147,
63,
1236
],
[
1236,
24,
250
]
],
[
[
147,
24,
869
],
[
869,
2... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxo... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab
Vinblasti... |
DB00467 | DB00491 | 1,467 | 127 | [
"DDInter644",
"DDInter1217"
] | Enoxacin | Miglitol | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
1467,
24,
127
]
],
[
[
1467,
23,
1194
],
[
1194,
62,
127
]
],
[
[
1467,
25,
1486
],
[
1486,
63,
127
]
],
[
[
1467,
64,
245
],
[
245,
... | [
[
[
"Enoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
],
[
"Ran... | Enoxacin may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Miglitol
Enoxacin may lead to a major life threatening interaction when taken with Methylprednisolone and Methylprednisolone may ... |
DB01403 | DB09481 | 9 | 460 | [
"DDInter1175",
"DDInter1113"
] | Methotrimeprazine | Magnesium carbonate | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
9,
23,
460
]
],
[
[
9,
63,
401
],
[
401,
23,
460
]
],
[
[
9,
1,
216
],
[
216,
23,
460
]
],
[
[
9,
40,
1630
],
[
1630,
23,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promet... | Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Methotrimeprazine (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine may cause ... |
DB00065 | DB14730 | 581 | 1,412 | [
"DDInter923",
"DDInter264"
] | Infliximab | Calaspargase pegol | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
581,
24,
1412
]
],
[
[
581,
24,
792
],
[
792,
24,
1412
]
],
[
[
581,
25,
250
],
[
250,
24,
1412
]
],
[
[
581,
63,
268
],
[
268,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
],... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Infliximab may lead to a major life threatening interaction when taken with Blinatumomab and Blinatumo... |
DB00745 | DB01211 | 307 | 609 | [
"DDInter1236",
"DDInter393"
] | Modafinil | Clarithromycin | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Minor | 0 | [
[
[
307,
23,
609
]
],
[
[
307,
6,
7524
],
[
7524,
45,
609
]
],
[
[
307,
18,
5415
],
[
5415,
46,
609
]
],
[
[
307,
18,
10375
],
[
10375,
... | [
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
]
],
[
[
"Modafinil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",... | Modafinil (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)
Modafinil (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Clarithromycin (Compound)
Modafinil (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Clarithromycin (Compound)... |
DB00047 | DB08886 | 176 | 637 | [
"DDInter932",
"DDInter126"
] | Insulin glargine | Asparaginase Erwinia chrysanthemi | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
176,
24,
637
]
],
[
[
176,
24,
167
],
[
167,
24,
637
]
],
[
[
176,
24,
1385
],
[
1385,
63,
637
]
],
[
[
176,
24,
1101
],
[
1101,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Insulin glargine may cause a moderate interaction that could exacerbate dis... |
DB00912 | DB01234 | 473 | 1,220 | [
"DDInter1581",
"DDInter513"
] | Repaglinide | Dexamethasone | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
473,
24,
1220
]
],
[
[
473,
63,
870
],
[
870,
1,
1220
]
],
[
[
473,
63,
175
],
[
175,
40,
1220
]
],
[
[
473,
24,
1486
],
[
1486,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles D... |
DB00317 | DB00863 | 883 | 1,194 | [
"DDInter810",
"DDInter1568"
] | Gefitinib | Ranitidine | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Moderate | 1 | [
[
[
883,
24,
1194
]
],
[
[
883,
24,
1127
],
[
1127,
1,
1194
]
],
[
[
883,
6,
8374
],
[
8374,
45,
1194
]
],
[
[
883,
18,
3390
],
[
3390,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nizatidine"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Nizatidine and Nizatidine (Compound) resembles Ranitidine (Compound)
Gefitinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ranitidine (Compound)
Gefitinib (Compound) downregulates RPN1 (Gene) and RPN1 (Gene) is do... |
DB00197 | DB00988 | 1,324 | 817 | [
"DDInter1881",
"DDInter584"
] | Troglitazone | Dopamine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Moderate | 1 | [
[
[
1324,
24,
817
]
],
[
[
1324,
24,
532
],
[
532,
1,
817
]
],
[
[
1324,
24,
1148
],
[
1148,
63,
817
]
],
[
[
1324,
24,
874
],
[
874,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) resembles Dopamine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that... |
DB00710 | DB01592 | 1,199 | 1,596 | [
"DDInter897",
"DDInter975"
] | Ibandronate | Iron | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
1199,
24,
1596
]
],
[
[
1199,
21,
29276
],
[
29276,
60,
1596
]
],
[
[
1199,
24,
1193
],
[
1193,
62,
1596
]
],
[
[
1199,
24,
1384
],
[
... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Ibandronate",
"{u} (Compound) causes {v} (Side Effect)",
"Haemoglobin"
],
[
"Haemoglobin",
"{u} (Side Effect) is caus... | Ibandronate (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Iron (Compound)
Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with I... |
DB00400 | DB00717 | 353 | 1,197 | [
"DDInter843",
"DDInter1312"
] | Griseofulvin | Norethisterone | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Major | 2 | [
[
[
353,
25,
1197
]
],
[
[
353,
24,
35
],
[
35,
40,
1197
]
],
[
[
353,
63,
989
],
[
989,
1,
1197
]
],
[
[
353,
64,
566
],
[
566,
40,... | [
[
[
"Griseofulvin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norethisterone"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
],
[
"Qu... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Norethisterone (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resembles Norethiste... |
DB00277 | DB00801 | 1,031 | 1,563 | [
"DDInter1791",
"DDInter850"
] | Theophylline | Halazepam | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Minor | 0 | [
[
[
1031,
23,
1563
]
],
[
[
1031,
23,
686
],
[
686,
1,
1563
]
],
[
[
1031,
23,
902
],
[
902,
40,
1563
]
],
[
[
1031,
62,
1174
],
[
1174,
... | [
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Halazepam"
]
],
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Oxazepam"
],
[
... | Theophylline may cause a minor interaction that can limit clinical effects when taken with Oxazepam and Oxazepam (Compound) resembles Halazepam (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Clobazam and Clobazam (Compound) resembles Halazepam (Compound)
Theophylli... |
DB00008 | DB00649 | 491 | 231 | [
"DDInter1407",
"DDInter1710"
] | Peginterferon alfa-2a | Stavudine | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Moderate | 1 | [
[
[
491,
24,
231
]
],
[
[
491,
25,
1477
],
[
1477,
40,
231
]
],
[
[
491,
24,
139
],
[
139,
1,
231
]
],
[
[
491,
24,
375
],
[
375,
63... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stavudine"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telbivudine"
],
... | Peginterferon alfa-2a may lead to a major life threatening interaction when taken with Telbivudine and Telbivudine (Compound) resembles Stavudine (Compound)
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) resembles Stavudine (Com... |
DB00264 | DB01575 | 88 | 1,054 | [
"DDInter1200",
"DDInter1005"
] | Metoprolol | Kaolin | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Minor | 0 | [
[
[
88,
23,
1054
]
],
[
[
88,
40,
17
],
[
17,
23,
1054
]
],
[
[
88,
1,
819
],
[
819,
23,
1054
]
],
[
[
88,
24,
407
],
[
407,
63,
... | [
[
[
"Metoprolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Kaolin"
]
],
[
[
"Metoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Sotalol"
],
[
"Sotalol",
"{u} may cause a minor interaction t... | Metoprolol (Compound) resembles Sotalol (Compound) and Sotalol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Metoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Metoprolol may cau... |
DB00539 | DB00731 | 11 | 1,144 | [
"DDInter1837",
"DDInter1269"
] | Toremifene | Nateglinide | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
11,
24,
1144
]
],
[
[
11,
6,
8374
],
[
8374,
45,
1144
]
],
[
[
11,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
11,
24,
804
],
[
804,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Toremifene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nateglinide (Compound)
Toremifene (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone ... |
DB00836 | DB01059 | 543 | 956 | [
"DDInter1088",
"DDInter1313"
] | Loperamide | Norfloxacin | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
543,
24,
956
]
],
[
[
543,
24,
872
],
[
872,
40,
956
]
],
[
[
543,
63,
1176
],
[
1176,
1,
956
]
],
[
[
543,
24,
1539
],
[
1539,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (... |
DB00041 | DB00401 | 1,648 | 84 | [
"DDInter38",
"DDInter1298"
] | Aldesleukin | Nisoldipine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Moderate | 1 | [
[
[
1648,
24,
84
]
],
[
[
1648,
24,
376
],
[
376,
40,
84
]
],
[
[
1648,
24,
1428
],
[
1428,
1,
84
]
],
[
[
1648,
24,
278
],
[
278,
6... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nisoldipine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
[... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Nisoldipine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nisoldipine (Compou... |
DB00087 | DB12001 | 599 | 564 | [
"DDInter41",
"DDInter7"
] | Alemtuzumab | Abemaciclib | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
599,
24,
564
]
],
[
[
599,
24,
748
],
[
748,
24,
564
]
],
[
[
599,
24,
151
],
[
151,
63,
564
]
],
[
[
599,
63,
1257
],
[
1257,
2... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Influenz... |
DB00262 | DB11817 | 552 | 1,259 | [
"DDInter302",
"DDInter165"
] | Carmustine | Baricitinib | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
552,
25,
1259
]
],
[
[
552,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
552,
24,
949
],
[
949,
24,
1259
]
],
[
[
552,
24,
1129
],
[
1129,
... | [
[
[
"Carmustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoi... |
DB00526 | DB00773 | 1,555 | 896 | [
"DDInter1355",
"DDInter702"
] | Oxaliplatin | Etoposide | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
1555,
24,
896
]
],
[
[
1555,
6,
13409
],
[
13409,
45,
896
]
],
[
[
1555,
25,
945
],
[
945,
62,
896
]
],
[
[
1555,
24,
739
],
[
739,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Oxaliplatin",
"{u} (Compound) binds {v} (Gene)",
"GSTT1"
],
[
"GSTT1",
"{u} (Gene) is bound by {v} (Compound)",
... | Oxaliplatin (Compound) binds GSTT1 (Gene) and GSTT1 (Gene) is bound by Etoposide (Compound)
Oxaliplatin may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Etoposide
Oxaliplatin may cause a moderate ... |
DB00653 | DB01082 | 544 | 1,448 | [
"DDInter1120",
"DDInter1713"
] | Magnesium sulfate | Streptomycin | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Major | 2 | [
[
[
544,
25,
1448
]
],
[
[
544,
25,
361
],
[
361,
24,
1448
]
],
[
[
544,
24,
1104
],
[
1104,
63,
1448
]
],
[
[
544,
24,
1008
],
[
1008,
... | [
[
[
"Magnesium sulfate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Streptomycin"
]
],
[
[
"Magnesium sulfate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neomycin"
],
[
"Neomycin",
... | Magnesium sulfate may lead to a major life threatening interaction when taken with Neomycin and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Tiludronic acid and Tilu... |
DB00388 | DB00598 | 1,636 | 1,523 | [
"DDInter1453",
"DDInter1013"
] | Phenylephrine | Labetalol | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Moderate | 1 | [
[
[
1636,
24,
1523
]
],
[
[
1636,
24,
455
],
[
455,
64,
1523
]
],
[
[
1636,
24,
1148
],
[
1148,
63,
1523
]
],
[
[
1636,
24,
1052
],
[
1052... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may lead to a major life threatening interaction when taken with Labetalol
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline m... |
DB00356 | DB01041 | 1,315 | 770 | [
"DDInter366",
"DDInter1789"
] | Chlorzoxazone | Thalidomide | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1315,
24,
770
]
],
[
[
1315,
6,
6365
],
[
6365,
45,
770
]
],
[
[
1315,
21,
28863
],
[
28863,
60,
770
]
],
[
[
1315,
24,
849
],
[
849,
... | [
[
[
"Chlorzoxazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Chlorzoxazone",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Comp... | Chlorzoxazone (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Chlorzoxazone (Compound) causes Lightheadedness (Side Effect) and Lightheadedness (Side Effect) is caused by Thalidomide (Compound)
Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01087 | DB01232 | 1,520 | 1,327 | [
"DDInter1520",
"DDInter1640"
] | Primaquine | Saquinavir | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
1520,
25,
1327
]
],
[
[
1520,
6,
8374
],
[
8374,
45,
1327
]
],
[
[
1520,
21,
28900
],
[
28900,
60,
1327
]
],
[
[
1520,
62,
112
],
[
11... | [
[
[
"Primaquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Primaquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Saquina... | Primaquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saquinavir (Compound)
Primaquine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Saquinavir (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazo... |
DB00280 | DB01064 | 494 | 1,148 | [
"DDInter575",
"DDInter987"
] | Disopyramide | Isoprenaline | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Major | 2 | [
[
[
494,
25,
1148
]
],
[
[
494,
24,
480
],
[
480,
24,
1148
]
],
[
[
494,
21,
29282
],
[
29282,
60,
1148
]
],
[
[
494,
24,
617
],
[
617,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Form... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Disopyramide (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Isoprenali... |
DB00460 | DB09075 | 612 | 498 | [
"DDInter1929",
"DDInter621"
] | Verteporfin | Edoxaban | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
612,
24,
498
]
],
[
[
612,
24,
714
],
[
714,
25,
498
]
],
[
[
612,
63,
291
],
[
291,
25,
498
]
],
[
[
612,
24,
1421
],
[
1421,
6... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
[
... | Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may lead to a major life threatening interaction when taken with Edoxaban
Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Argatroban and Argatroban may lead to a ... |
DB00668 | DB09564 | 874 | 1,296 | [
"DDInter652",
"DDInter930"
] | Epinephrine | Insulin degludec | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
874,
24,
1296
]
],
[
[
874,
64,
17
],
[
17,
24,
1296
]
],
[
[
874,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
874,
63,
1645
],
[
1645,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
],
[
"Sotal... | Epinephrine may lead to a major life threatening interaction when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may ca... |
DB00176 | DB00912 | 529 | 473 | [
"DDInter770",
"DDInter1581"
] | Fluvoxamine | Repaglinide | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
529,
24,
473
]
],
[
[
529,
6,
8374
],
[
8374,
45,
473
]
],
[
[
529,
21,
28873
],
[
28873,
60,
473
]
],
[
[
529,
25,
73
],
[
73,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Fluvoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Repaglinide (Compound)
Fluvoxamine (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Repaglinide (Compound)
Fluvoxamine may lead to a major life threatening interaction when taken with Phentermine and Phenter... |
DB01218 | DB08881 | 1,493 | 868 | [
"DDInter852",
"DDInter1925"
] | Halofantrine | Vemurafenib | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1493,
25,
868
]
],
[
[
1493,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1493,
18,
2183
],
[
2183,
57,
868
]
],
[
[
1493,
21,
29106
],
[
29106... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Halofantrine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ve... | Halofantrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Halofantrine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Vemurafenib (Compound)
Halofantrine (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Vemurafenib (Compoun... |
DB01142 | DB06701 | 1,264 | 1,177 | [
"DDInter593",
"DDInter521"
] | Doxepin | Dexmethylphenidate | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer s... | Moderate | 1 | [
[
[
1264,
24,
1177
]
],
[
[
1264,
63,
895
],
[
895,
1,
1177
]
],
[
[
1264,
63,
19
],
[
19,
40,
1177
]
],
[
[
1264,
6,
7390
],
[
7390,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexmethylphenidate"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylphenidate"
],
... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Methylphenidate and Methylphenidate (Compound) resembles Dexmethylphenidate (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dexmethy... |
DB00776 | DB00877 | 1,335 | 629 | [
"DDInter1360",
"DDInter1678"
] | Oxcarbazepine | Sirolimus | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1335,
24,
629
]
],
[
[
1335,
6,
7524
],
[
7524,
45,
629
]
],
[
[
1335,
7,
8587
],
[
8587,
57,
629
]
],
[
[
1335,
21,
28898
],
[
28898,... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Oxcarbazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compou... | Oxcarbazepine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Sirolimus (Compound)
Oxcarbazepine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Sirolimus (Compound)
Oxcarbazepine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Sirolimus (Comp... |
DB00264 | DB01075 | 88 | 1,376 | [
"DDInter1200",
"DDInter569"
] | Metoprolol | Diphenhydramine | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
88,
24,
1376
]
],
[
[
88,
24,
401
],
[
401,
24,
1376
]
],
[
[
88,
6,
8803
],
[
8803,
45,
1376
]
],
[
[
88,
21,
28921
],
[
28921,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Metoprolol (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Diphenhydramine (Compound)
Me... |
DB00502 | DB11837 | 1,300 | 1,297 | [
"DDInter853",
"DDInter1351"
] | Haloperidol | Osilodrostat | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
1300,
25,
1297
]
],
[
[
1300,
23,
112
],
[
112,
23,
1297
]
],
[
[
1300,
24,
222
],
[
222,
23,
1297
]
],
[
[
1300,
25,
401
],
[
401,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Haloperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Haloperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and... |
DB00254 | DB00436 | 964 | 323 | [
"DDInter598",
"DDInter179"
] | Doxycycline | Bendroflumethiazide | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Minor | 0 | [
[
[
964,
23,
323
]
],
[
[
964,
23,
1014
],
[
1014,
1,
323
]
],
[
[
964,
24,
126
],
[
126,
62,
323
]
],
[
[
964,
1,
1669
],
[
1669,
6... | [
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bendroflumethiazide"
]
],
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Benzthiazide"
],... | Doxycycline may cause a minor interaction that can limit clinical effects when taken with Benzthiazide and Benzthiazide (Compound) resembles Bendroflumethiazide (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that... |
DB00060 | DB11995 | 912 | 1,634 | [
"DDInter947",
"DDInter143"
] | Interferon beta-1a | Avatrombopag | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Moderate | 1 | [
[
[
912,
24,
1634
]
],
[
[
912,
24,
1622
],
[
1622,
24,
1634
]
],
[
[
912,
63,
342
],
[
342,
24,
1634
]
],
[
[
912,
24,
971
],
[
971,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avatrombopag"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconaz... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00734 | DB01211 | 1,664 | 609 | [
"DDInter1605",
"DDInter393"
] | Risperidone | Clarithromycin | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1664,
24,
609
]
],
[
[
1664,
6,
4973
],
[
4973,
45,
609
]
],
[
[
1664,
7,
5415
],
[
5415,
46,
609
]
],
[
[
1664,
21,
28759
],
[
28759,... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Risperidone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Risperidone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Risperidone (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Clarithromycin (Compound)
Risperidone (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effe... |
DB01267 | DB08882 | 519 | 1,281 | [
"DDInter1381",
"DDInter1070"
] | Paliperidone | Linagliptin | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
519,
24,
1281
]
],
[
[
519,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
519,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
519,
21,
28966
],
[
28966,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Paliperidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Paliperidone (Compound) causes Upper respiratory tract infec... |
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