drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00439 | DB01097 | 289 | 1,377 | [
"DDInter341",
"DDInter1033"
] | Cerivastatin | Leflunomide | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
289,
25,
1377
]
],
[
[
289,
24,
597
],
[
597,
24,
1377
]
],
[
[
289,
24,
1434
],
[
1434,
63,
1377
]
],
[
[
289,
63,
10
],
[
10,
... | [
[
[
"Cerivastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
[
"... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Benzni... |
DB00559 | DB00959 | 152 | 1,486 | [
"DDInter223",
"DDInter1191"
] | Bosentan | Methylprednisolone | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
152,
24,
1486
]
],
[
[
152,
24,
175
],
[
175,
40,
1486
]
],
[
[
152,
24,
167
],
[
167,
1,
1486
]
],
[
[
152,
63,
251
],
[
251,
1... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Meth... |
DB09133 | DB14761 | 1,527 | 242 | [
"DDInter965",
"DDInter1578"
] | Iothalamic acid | Remdesivir | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1527,
24,
242
]
],
[
[
1527,
64,
1512
],
[
1512,
24,
242
]
],
[
[
1527,
63,
1648
],
[
1648,
24,
242
]
],
[
[
1527,
64,
1512
],
[
1512,... | [
[
[
"Iothalamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Iothalamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diclofenac"
],
[
"... | Iothalamic acid may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Iothalamic acid may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleuki... |
DB00400 | DB00655 | 353 | 559 | [
"DDInter843",
"DDInter682"
] | Griseofulvin | Estrone | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Moderate | 1 | [
[
[
353,
24,
559
]
],
[
[
353,
24,
35
],
[
35,
40,
559
]
],
[
[
353,
63,
380
],
[
380,
40,
559
]
],
[
[
353,
24,
1438
],
[
1438,
1,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estrone"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
],
[
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Estrone (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles E... |
DB00060 | DB00627 | 912 | 265 | [
"DDInter947",
"DDInter1286"
] | Interferon beta-1a | Niacin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Moderate | 1 | [
[
[
912,
24,
265
]
],
[
[
912,
24,
1647
],
[
1647,
24,
265
]
],
[
[
912,
63,
1560
],
[
1560,
24,
265
]
],
[
[
912,
24,
384
],
[
384,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niacin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
]... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Niacin
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase ... |
DB08875 | DB09068 | 1,618 | 1,427 | [
"DDInter262",
"DDInter1948"
] | Cabozantinib | Vortioxetine | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1618,
24,
1427
]
],
[
[
1618,
24,
1320
],
[
1320,
63,
1427
]
],
[
[
1618,
64,
25
],
[
25,
24,
1427
]
],
[
[
1618,
25,
1604
],
[
1604,
... | [
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
... | Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Cabozantinib may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may ... |
DB00762 | DB06643 | 613 | 1,136 | [
"DDInter973",
"DDInter500"
] | Irinotecan | Denosumab | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
613,
24,
1136
]
],
[
[
613,
24,
1213
],
[
1213,
24,
1136
]
],
[
[
613,
63,
1555
],
[
1555,
24,
1136
]
],
[
[
613,
25,
1377
],
[
1377,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxalipla... |
DB01118 | DB08871 | 33 | 36 | [
"DDInter76",
"DDInter666"
] | Amiodarone | Eribulin | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
33,
25,
36
]
],
[
[
33,
63,
1488
],
[
1488,
24,
36
]
],
[
[
33,
24,
973
],
[
973,
24,
36
]
],
[
[
33,
64,
1424
],
[
1424,
24,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
"Fludarabine... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclit... |
DB00563 | DB12240 | 663 | 110 | [
"DDInter1174",
"DDInter1485"
] | Methotrexate | Polatuzumab vedotin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
663,
24,
110
]
],
[
[
663,
24,
913
],
[
913,
23,
110
]
],
[
[
663,
24,
467
],
[
467,
24,
110
]
],
[
[
663,
63,
268
],
[
268,
24,... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Simvasta... |
DB00418 | DB08882 | 536 | 1,281 | [
"DDInter1650",
"DDInter1070"
] | Secobarbital | Linagliptin | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
536,
24,
1281
]
],
[
[
536,
21,
29081
],
[
29081,
60,
1281
]
],
[
[
536,
24,
251
],
[
251,
24,
1281
]
],
[
[
536,
24,
1320
],
[
1320,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Secobarbital",
"{u} (Compound) causes {v} (Side Effect)",
"Angioedema"
],
[
"Angioedema",
"{u} (Side Effect) ... | Secobarbital (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Linagliptin (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken... |
DB00072 | DB09498 | 550 | 810 | [
"DDInter1846",
"DDInter1715"
] | Trastuzumab | Strontium chloride Sr-89 | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
550,
24,
810
]
],
[
[
550,
24,
597
],
[
597,
24,
810
]
],
[
[
550,
25,
51
],
[
51,
24,
810
]
],
[
[
550,
24,
738
],
[
738,
63,
... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphen... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Trastuzumab may lead to a major life threatening interaction when taken with Daunorubic... |
DB00476 | DB00758 | 109 | 1,347 | [
"DDInter608",
"DDInter413"
] | Duloxetine | Clopidogrel | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Moderate | 1 | [
[
[
109,
24,
1347
]
],
[
[
109,
63,
1018
],
[
1018,
25,
1347
]
],
[
[
109,
6,
7950
],
[
7950,
45,
1347
]
],
[
[
109,
21,
29042
],
[
29042,... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
],
[
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Duloxetine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clopidogrel (Compound)
Duloxetine (Compound) causes ... |
DB00344 | DB00619 | 1,302 | 1,419 | [
"DDInter1543",
"DDInter909"
] | Protriptyline | Imatinib | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
1302,
24,
1419
]
],
[
[
1302,
6,
4973
],
[
4973,
45,
1419
]
],
[
[
1302,
7,
8924
],
[
8924,
46,
1419
]
],
[
[
1302,
18,
5818
],
[
5818... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Protriptyline",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Protriptyline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Imatinib (Compound)
Protriptyline (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is upregulated by Imatinib (Compound)
Protriptyline (Compound) downregulates ATP6V0B (Gene) and ATP6V0B (Gene) is downregulated by Imatinib (Compound)
Protripty... |
DB00704 | DB11979 | 267 | 1,320 | [
"DDInter1263",
"DDInter625"
] | Naltrexone | Elagolix | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
267,
24,
1320
]
],
[
[
267,
63,
168
],
[
168,
23,
1320
]
],
[
[
267,
63,
79
],
[
79,
24,
1320
]
],
[
[
267,
24,
26
],
[
26,
24,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib m... |
DB00619 | DB01050 | 1,419 | 848 | [
"DDInter909",
"DDInter900"
] | Imatinib | Ibuprofen | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1419,
24,
848
]
],
[
[
1419,
24,
1307
],
[
1307,
1,
848
]
],
[
[
1419,
6,
1829
],
[
1829,
45,
848
]
],
[
[
1419,
21,
28773
],
[
28773,... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
"M... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan (Compound) resembles Ibuprofen (Compound)
Imatinib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Imatinib (Compound) causes Urethral disorder (Side Effect) and Urethral disorder... |
DB00843 | DB08868 | 479 | 1,011 | [
"DDInter583",
"DDInter737"
] | Donepezil | Fingolimod | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
479,
24,
1011
]
],
[
[
479,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
479,
21,
28859
],
[
28859,
60,
1011
]
],
[
[
479,
24,
112
],
[
112,... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Donepezil",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Donepezil (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Donepezil (Compound) causes Atrioventricular block (Side Effect) and Atrioventricular block (Side Effect) is caused by Fingolimod (Compound)
Donepezil may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01095 | DB08912 | 671 | 1,040 | [
"DDInter769",
"DDInter462"
] | Fluvastatin | Dabrafenib | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
671,
24,
1040
]
],
[
[
671,
6,
13478
],
[
13478,
45,
1040
]
],
[
[
671,
7,
2969
],
[
2969,
46,
1040
]
],
[
[
671,
18,
12411
],
[
12411... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Fluvastatin",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B3"
],
[
"SLCO1B3",
"{u} (Gene) is bound by {v} (Compoun... | Fluvastatin (Compound) binds SLCO1B3 (Gene) and SLCO1B3 (Gene) is bound by Dabrafenib (Compound)
Fluvastatin (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Dabrafenib (Compound)
Fluvastatin (Compound) downregulates MYL9 (Gene) and MYL9 (Gene) is upregulated by Dabrafenib (Compound)
Fluvastatin... |
DB00889 | DB00998 | 1,133 | 404 | [
"DDInter840",
"DDInter788"
] | Granisetron | Frovatriptan | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Frovatriptan is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular those associated with menstruation. Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head. | Major | 2 | [
[
[
1133,
25,
404
]
],
[
[
1133,
21,
28921
],
[
28921,
60,
404
]
],
[
[
1133,
25,
868
],
[
868,
63,
404
]
],
[
[
1133,
24,
1619
],
[
1619,... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Frovatriptan"
]
],
[
[
"Granisetron",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is caused by {v} (... | Granisetron (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Frovatriptan (Compound)
Granisetron may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Frovatriptan
Gra... |
DB01263 | DB12332 | 859 | 1,619 | [
"DDInter1494",
"DDInter1626"
] | Posaconazole | Rucaparib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
859,
24,
1619
]
],
[
[
859,
62,
112
],
[
112,
23,
1619
]
],
[
[
859,
25,
1135
],
[
1135,
23,
1619
]
],
[
[
859,
24,
309
],
[
309,
... | [
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Posaconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Posaconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cau... |
DB01138 | DB11986 | 804 | 484 | [
"DDInter1726",
"DDInter648"
] | Sulfinpyrazone | Entrectinib | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
804,
24,
484
]
],
[
[
804,
24,
466
],
[
466,
62,
484
]
],
[
[
804,
24,
1135
],
[
1135,
23,
484
]
],
[
[
804,
63,
222
],
[
222,
2... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol ... |
DB00553 | DB01044 | 92 | 246 | [
"DDInter1177",
"DDInter809"
] | Methoxsalen | Gatifloxacin | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Moderate | 1 | [
[
[
92,
24,
246
]
],
[
[
92,
24,
739
],
[
739,
1,
246
]
],
[
[
92,
63,
1176
],
[
1176,
1,
246
]
],
[
[
92,
24,
945
],
[
945,
40,
... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxac... |
DB00023 | DB00500 | 305 | 24 | [
"DDInter127",
"DDInter1831"
] | Asparaginase Escherichia coli | Tolmetin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Moderate | 1 | [
[
[
305,
24,
24
]
],
[
[
305,
24,
886
],
[
886,
1,
24
]
],
[
[
305,
24,
1062
],
[
1062,
40,
24
]
],
[
[
305,
24,
477
],
[
477,
63,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolmetin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) resembles Tolmetin (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Tolcapone and Tolcapone (Compound) ... |
DB00220 | DB00863 | 798 | 1,194 | [
"DDInter1276",
"DDInter1568"
] | Nelfinavir | Ranitidine | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Minor | 0 | [
[
[
798,
23,
1194
]
],
[
[
798,
23,
1127
],
[
1127,
1,
1194
]
],
[
[
798,
6,
8374
],
[
8374,
45,
1194
]
],
[
[
798,
18,
5833
],
[
5833,
... | [
[
[
"Nelfinavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
]
],
[
[
"Nelfinavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
],
[
... | Nelfinavir may cause a minor interaction that can limit clinical effects when taken with Nizatidine and Nizatidine (Compound) resembles Ranitidine (Compound)
Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ranitidine (Compound)
Nelfinavir (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is... |
DB08896 | DB08903 | 292 | 996 | [
"DDInter1576",
"DDInter170"
] | Regorafenib | Bedaquiline | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
292,
24,
996
]
],
[
[
292,
6,
8374
],
[
8374,
45,
996
]
],
[
[
292,
21,
29267
],
[
29267,
60,
996
]
],
[
[
292,
64,
848
],
[
848,
... | [
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Regorafenib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Regorafenib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Regorafenib (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Bedaquiline (Compound)
Regorafenib may lead to a major life threatening interac... |
DB00726 | DB01205 | 1,164 | 1,404 | [
"DDInter1876",
"DDInter748"
] | Trimipramine | Flumazenil | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. | Major | 2 | [
[
[
1164,
25,
1404
]
],
[
[
1164,
21,
28997
],
[
28997,
60,
1404
]
],
[
[
1164,
35,
1264
],
[
1264,
25,
1404
]
],
[
[
1164,
1,
21
],
[
21,... | [
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Flumazenil"
]
],
[
[
"Trimipramine",
"{u} (Compound) causes {v} (Side Effect)",
"Ill-defined disorder"
],
[
"Ill-defined disorder",
"{u} (Side Effe... | Trimipramine (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Flumazenil (Compound)
Trimipramine (Compound) resembles Doxepin (Compound) and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may lead t... |
DB08867 | DB09049 | 807 | 1,135 | [
"DDInter1897",
"DDInter1261"
] | Ulipristal | Naloxegol | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Minor | 0 | [
[
[
807,
23,
1135
]
],
[
[
807,
24,
971
],
[
971,
62,
1135
]
],
[
[
807,
63,
478
],
[
478,
23,
1135
]
],
[
[
807,
25,
1456
],
[
1456,
... | [
[
[
"Ulipristal",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
]
],
[
[
"Ulipristal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
[
... | Ulipristal may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Ulipristal may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Niloti... |
DB00705 | DB11986 | 441 | 484 | [
"DDInter496",
"DDInter648"
] | Delavirdine | Entrectinib | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
441,
25,
484
]
],
[
[
441,
23,
466
],
[
466,
62,
484
]
],
[
[
441,
25,
1135
],
[
1135,
23,
484
]
],
[
[
441,
23,
222
],
[
222,
2... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Delavirdine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
"Darolut... | Delavirdine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Delavirdine may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause... |
DB00031 | DB11095 | 20 | 235 | [
"DDInter1764",
"DDInter505"
] | Tenecteplase | Desirudin | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
20,
25,
235
]
],
[
[
20,
23,
297
],
[
297,
23,
235
]
],
[
[
20,
24,
1100
],
[
1100,
24,
235
]
],
[
[
20,
24,
298
],
[
298,
63,
... | [
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Tenecteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
... | Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may ... |
DB00434 | DB10429 | 13 | 200 | [
"DDInter459",
"DDInter282"
] | Cyproheptadine | Candida albicans | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
13,
24,
200
]
],
[
[
13,
63,
701
],
[
701,
24,
200
]
],
[
[
13,
24,
662
],
[
662,
24,
200
]
],
[
[
13,
63,
701
],
[
701,
24,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Carbino... |
DB00550 | DB09293 | 99 | 116 | [
"DDInter1541",
"DDInter954"
] | Propylthiouracil | Iodide I-131 | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
99,
24,
116
]
],
[
[
99,
24,
126
],
[
126,
24,
116
]
],
[
[
99,
63,
542
],
[
542,
24,
116
]
],
[
[
99,
24,
877
],
[
877,
63,
... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
... | Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxi... |
DB00748 | DB00844 | 662 | 314 | [
"DDInter297",
"DDInter1257"
] | Carbinoxamine | Nalbuphine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Moderate | 1 | [
[
[
662,
24,
314
]
],
[
[
662,
63,
828
],
[
828,
40,
314
]
],
[
[
662,
63,
421
],
[
421,
1,
314
]
],
[
[
662,
63,
475
],
[
475,
25,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Nalbuphine (... |
DB01200 | DB09054 | 469 | 384 | [
"DDInter243",
"DDInter905"
] | Bromocriptine | Idelalisib | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
469,
24,
384
]
],
[
[
469,
62,
888
],
[
888,
24,
384
]
],
[
[
469,
63,
600
],
[
600,
24,
384
]
],
[
[
469,
24,
1619
],
[
1619,
6... | [
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Bromocriptine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tamoxifen"
],
[... | Bromocriptine may cause a minor interaction that can limit clinical effects when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Flu... |
DB01041 | DB01267 | 770 | 519 | [
"DDInter1789",
"DDInter1381"
] | Thalidomide | Paliperidone | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
770,
24,
519
]
],
[
[
770,
63,
1664
],
[
1664,
1,
519
]
],
[
[
770,
24,
924
],
[
924,
1,
519
]
],
[
[
770,
6,
7524
],
[
7524,
45... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (... |
DB01222 | DB08865 | 617 | 1,593 | [
"DDInter246",
"DDInter448"
] | Budesonide | Crizotinib | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
617,
24,
1593
]
],
[
[
617,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
617,
7,
7972
],
[
7972,
46,
1593
]
],
[
[
617,
18,
1720
],
[
1720,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Budesonide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Budesonide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Budesonide (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Crizotinib (Compound)
Budesonide (Compound) downregulates RELB (Gene) and RELB (Gene) is upregulated by Crizotinib (Compound)
Budesonide (Co... |
DB00738 | DB01175 | 485 | 318 | [
"DDInter1420",
"DDInter672"
] | Pentamidine | Escitalopram | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Major | 2 | [
[
[
485,
25,
318
]
],
[
[
485,
64,
1230
],
[
1230,
1,
318
]
],
[
[
485,
6,
8374
],
[
8374,
45,
318
]
],
[
[
485,
21,
29243
],
[
29243,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
]
],
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Citalopram"
],
[
"Citalopram",
"{... | Pentamidine may lead to a major life threatening interaction when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Pentamidine (Compound) causes Wheezing (Side Effect) and Wheezing (Side Eff... |
DB00059 | DB06212 | 1,560 | 165 | [
"DDInter1404",
"DDInter1833"
] | Pegaspargase | Tolvaptan | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
1560,
24,
165
]
],
[
[
1560,
24,
522
],
[
522,
1,
165
]
],
[
[
1560,
24,
1450
],
[
1450,
63,
165
]
],
[
[
1560,
24,
267
],
[
267,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast (Compound) resembles Tolvaptan (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction... |
DB00196 | DB06414 | 600 | 655 | [
"DDInter743",
"DDInter703"
] | Fluconazole | Etravirine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
600,
24,
655
]
],
[
[
600,
24,
786
],
[
786,
40,
655
]
],
[
[
600,
6,
4973
],
[
4973,
45,
655
]
],
[
[
600,
21,
28723
],
[
28723,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
],
[... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Etravirine (Compound)
Fluconazole (Compound) causes Malnutrition (Side Effect) and Mal... |
DB00202 | DB00994 | 190 | 361 | [
"DDInter1716",
"DDInter1277"
] | Succinylcholine | Neomycin | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Major | 2 | [
[
[
190,
25,
361
]
],
[
[
190,
21,
28778
],
[
28778,
60,
361
]
],
[
[
190,
24,
608
],
[
608,
23,
361
]
],
[
[
190,
25,
1132
],
[
1132,
... | [
[
[
"Succinylcholine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neomycin"
]
],
[
[
"Succinylcholine",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphylactic shock",
"{u} (Side Effe... | Succinylcholine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Neomycin (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects w... |
DB01124 | DB11228 | 1,411 | 721 | [
"DDInter1828",
"DDInter1184"
] | Tolbutamide | Methylcellulose | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum... | Minor | 0 | [
[
[
1411,
23,
721
]
],
[
[
1411,
1,
959
],
[
959,
23,
721
]
],
[
[
1411,
63,
127
],
[
127,
23,
721
]
],
[
[
1411,
24,
1296
],
[
1296,
... | [
[
[
"Tolbutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methylcellulose"
]
],
[
[
"Tolbutamide",
"{u} (Compound) resembles {v} (Compound)",
"Glipizide"
],
[
"Glipizide",
"{u} may cause a mino... | Tolbutamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a minor interaction that can limit clinical effects when taken with Methylcellulose
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Miglitol may cause a minor interaction that can limit... |
DB01276 | DB06595 | 123 | 1,491 | [
"DDInter706",
"DDInter1214"
] | Exenatide | Midostaurin | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
123,
24,
1491
]
],
[
[
123,
63,
1148
],
[
1148,
24,
1491
]
],
[
[
123,
24,
659
],
[
659,
63,
1491
]
],
[
[
123,
62,
1463
],
[
1463,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vil... |
DB00046 | DB01144 | 1,179 | 1,326 | [
"DDInter940",
"DDInter540"
] | Insulin lispro | Diclofenamide | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Moderate | 1 | [
[
[
1179,
24,
1326
]
],
[
[
1179,
24,
504
],
[
504,
1,
1326
]
],
[
[
1179,
24,
359
],
[
359,
40,
1326
]
],
[
[
1179,
24,
1620
],
[
1620,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiaz... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Diclofenamide (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compo... |
DB00402 | DB01259 | 1,407 | 392 | [
"DDInter685",
"DDInter1024"
] | Eszopiclone | Lapatinib | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1407,
24,
392
]
],
[
[
1407,
6,
8374
],
[
8374,
45,
392
]
],
[
[
1407,
21,
28688
],
[
28688,
60,
392
]
],
[
[
1407,
24,
918
],
[
918,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Eszopiclone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Eszopiclone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Eszopiclone (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and B... |
DB01001 | DB01015 | 688 | 1,247 | [
"DDInter1632",
"DDInter1724"
] | Salbutamol | Sulfamethoxazole | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Minor | 0 | [
[
[
688,
23,
1247
]
],
[
[
688,
6,
8374
],
[
8374,
45,
1247
]
],
[
[
688,
21,
29027
],
[
29027,
60,
1247
]
],
[
[
688,
63,
11
],
[
11,
... | [
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Salbutamol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfamethoxazole (Compound)
Salbutamol (Compound) causes Ataxia (Side Effect) and Ataxia (Side Effect) is caused by Sulfamethoxazole (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Toremifene an... |
DB00674 | DB11718 | 1,516 | 927 | [
"DDInter802",
"DDInter640"
] | Galantamine | Encorafenib | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1516,
24,
927
]
],
[
[
1516,
24,
112
],
[
112,
23,
927
]
],
[
[
1516,
24,
1491
],
[
1491,
24,
927
]
],
[
[
1516,
63,
1010
],
[
1010,
... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin an... |
DB00422 | DB06706 | 895 | 468 | [
"DDInter1189",
"DDInter985"
] | Methylphenidate | Isometheptene | Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cogni... | Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches. | Moderate | 1 | [
[
[
895,
24,
468
]
],
[
[
895,
24,
480
],
[
480,
24,
468
]
],
[
[
895,
1,
1177
],
[
1177,
24,
468
]
],
[
[
895,
24,
144
],
[
144,
63... | [
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isometheptene"
]
],
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
... | Methylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isometheptene
Methylphenidate (Compound) resembles Dexmethylphenidate (Compound) and Dex
Methylphenidate may cause a m... |
DB00612 | DB04843 | 1,121 | 1,511 | [
"DDInter216",
"DDInter1149"
] | Bisoprolol | Mepenzolate | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1121,
24,
1511
]
],
[
[
1121,
24,
1192
],
[
1192,
24,
1511
]
],
[
[
1121,
63,
352
],
[
352,
24,
1511
]
],
[
[
1121,
21,
28898
],
[
288... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Trospium and... |
DB00400 | DB06237 | 353 | 438 | [
"DDInter843",
"DDInter141"
] | Griseofulvin | Avanafil | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual ... | Moderate | 1 | [
[
[
353,
24,
438
]
],
[
[
353,
6,
8374
],
[
8374,
45,
438
]
],
[
[
353,
21,
29093
],
[
29093,
60,
438
]
],
[
[
353,
24,
129
],
[
129,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avanafil"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Avanafil (Compound)
Griseofulvin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Avanafil (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enza... |
DB06700 | DB09241 | 643 | 1,629 | [
"DDInter511",
"DDInter1186"
] | Desvenlafaxine | Methylene blue | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
643,
25,
1629
]
],
[
[
643,
63,
1148
],
[
1148,
24,
1629
]
],
[
[
643,
24,
659
],
[
659,
24,
1629
]
],
[
[
643,
64,
73
],
[
73,
... | [
[
[
"Desvenlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Vilan... |
DB08881 | DB08931 | 868 | 947 | [
"DDInter1925",
"DDInter1600"
] | Vemurafenib | Riociguat | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Moderate | 1 | [
[
[
868,
24,
947
]
],
[
[
868,
63,
1478
],
[
1478,
24,
947
]
],
[
[
868,
64,
609
],
[
609,
24,
947
]
],
[
[
868,
25,
913
],
[
913,
6... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riociguat"
]
],
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Riociguat
Vemurafenib may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may... |
DB00850 | DB04868 | 1,630 | 478 | [
"DDInter1432",
"DDInter1293"
] | Perphenazine | Nilotinib | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1630,
25,
478
]
],
[
[
1630,
6,
6017
],
[
6017,
45,
478
]
],
[
[
1630,
7,
7669
],
[
7669,
46,
478
]
],
[
[
1630,
18,
2183
],
[
2183,
... | [
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Perphenazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Nilo... | Perphenazine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Perphenazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Nilotinib (Compound)
Perphenazine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Nilotinib (Compound)
Perphenazin... |
DB00622 | DB06691 | 1,081 | 849 | [
"DDInter1287",
"DDInter1155"
] | Nicardipine | Mepyramine | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1081,
24,
849
]
],
[
[
1081,
6,
12523
],
[
12523,
45,
849
]
],
[
[
1081,
24,
770
],
[
770,
24,
849
]
],
[
[
1081,
63,
1648
],
[
1648,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Nicardipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Nicardipine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Nicardipine ma... |
DB00637 | DB01110 | 1,557 | 86 | [
"DDInter128",
"DDInter1209"
] | Astemizole | Miconazole | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Major | 2 | [
[
[
1557,
25,
86
]
],
[
[
1557,
6,
3958
],
[
3958,
45,
86
]
],
[
[
1557,
7,
2692
],
[
2692,
46,
86
]
],
[
[
1557,
18,
2183
],
[
2183,
... | [
[
[
"Astemizole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Miconazole"
]
],
[
[
"Astemizole",
"{u} (Compound) binds {v} (Gene)",
"KCNH2"
],
[
"KCNH2",
"{u} (Gene) is bound by {v} (Compound)",
"Miconazol... | Astemizole (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Miconazole (Compound)
Astemizole (Compound) upregulates KIT (Gene) and KIT (Gene) is upregulated by Miconazole (Compound)
Astemizole (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Miconazole (Compound)
Astemizole may lead ... |
DB00959 | DB09420 | 1,486 | 1,074 | [
"DDInter1191",
"DDInter953"
] | Methylprednisolone | Iodide I-123 | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1486,
24,
1074
]
],
[
[
1486,
24,
1004
],
[
1004,
63,
1074
]
],
[
[
1486,
62,
523
],
[
523,
24,
1074
]
],
[
[
1486,
63,
126
],
[
126,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl sa... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Methylprednisolone may cause a minor interaction that can limit clinical effects when ta... |
DB05351 | DB06616 | 101 | 594 | [
"DDInter519",
"DDInter224"
] | Dexlansoprazole | Bosutinib | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
101,
24,
594
]
],
[
[
101,
63,
883
],
[
883,
1,
594
]
],
[
[
101,
25,
786
],
[
786,
63,
594
]
],
[
[
101,
64,
663
],
[
663,
24,
... | [
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
... | Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Dexlansoprazole may lead to a major life threatening interaction when taken with Rilpivirine and Rilpivirine may cause a moderate interaction that could exace... |
DB06650 | DB08868 | 1,500 | 1,011 | [
"DDInter1324",
"DDInter737"
] | Ofatumumab | Fingolimod | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1500,
25,
1011
]
],
[
[
1500,
24,
748
],
[
748,
63,
1011
]
],
[
[
1500,
63,
1136
],
[
1136,
24,
1011
]
],
[
[
1500,
24,
1430
],
[
1430... | [
[
[
"Ofatumumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Ofatumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Anthr... | Ofatumumab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Ofatumumab may cause a moderate interaction that could exacerbate diseases when taken with Denosumab a... |
DB00106 | DB00582 | 618 | 1,622 | [
"DDInter4",
"DDInter1946"
] | Abarelix | Voriconazole | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
618,
24,
1622
]
],
[
[
618,
23,
112
],
[
112,
62,
1622
]
],
[
[
618,
24,
823
],
[
823,
63,
1622
]
],
[
[
618,
24,
1424
],
[
1424,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Voriconazole
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole and T... |
DB00741 | DB10276 | 167 | 1,624 | [
"DDInter885",
"DDInter1623"
] | Hydrocortisone | Rotavirus vaccine | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
167,
25,
1624
]
],
[
[
167,
1,
617
],
[
617,
24,
1624
]
],
[
[
167,
63,
1648
],
[
1648,
25,
1624
]
],
[
[
167,
25,
770
],
[
770,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Budesonide"
],
[
"Budesonide",
"{u} may cause a moderat... | Hydrocortisone (Compound) resembles Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may lead to a major life t... |
DB00372 | DB09118 | 999 | 1,580 | [
"DDInter1793",
"DDInter1711"
] | Thiethylperazine | Stiripentol | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
999,
24,
1580
]
],
[
[
999,
24,
1532
],
[
1532,
24,
1580
]
],
[
[
999,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
999,
63,
1594
],
[
1594,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyv... |
DB00512 | DB15066 | 91 | 445 | [
"DDInter1916",
"DDInter821"
] | Vancomycin | Givosiran | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Moderate | 1 | [
[
[
91,
24,
445
]
],
[
[
91,
24,
1555
],
[
1555,
24,
445
]
],
[
[
91,
25,
1211
],
[
1211,
25,
445
]
],
[
[
91,
24,
1555
],
[
1555,
2... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Givosiran"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Vancomycin may lead to a major life threatening interaction when taken with Ioxilan and Ioxilan may lead to a m... |
DB01324 | DB09080 | 178 | 144 | [
"DDInter1490",
"DDInter1331"
] | Polythiazide | Olodaterol | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
178,
24,
144
]
],
[
[
178,
1,
504
],
[
504,
24,
144
]
],
[
[
178,
63,
11
],
[
11,
24,
144
]
],
[
[
178,
64,
57
],
[
57,
24,
... | [
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Polythiazide",
"{u} (Compound) resembles {v} (Compound)",
"Hydrochlorothiazide"
],
[
"Hydrochlorothiazide",
"{... | Polythiazide (Compound) resembles Hydrochlorothiazide (Compound) and Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene may cause a moderate ... |
DB09074 | DB15093 | 1,362 | 1,654 | [
"DDInter1327",
"DDInter1698"
] | Olaparib | Somapacitan | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1362,
24,
1654
]
],
[
[
1362,
63,
608
],
[
608,
23,
1654
]
],
[
[
1362,
25,
351
],
[
351,
24,
1654
]
],
[
[
1362,
63,
310
],
[
310,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Olaparib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a moder... |
DB01268 | DB08912 | 1,151 | 1,040 | [
"DDInter1731",
"DDInter462"
] | Sunitinib | Dabrafenib | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1151,
24,
1040
]
],
[
[
1151,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
1151,
7,
10643
],
[
10643,
46,
1040
]
],
[
[
1151,
6,
6732
],
[
673... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Sunitinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Sunitinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Sunitinib (Compound) upregulates EAPP (Gene) and EAPP (Gene) is upregulated by Dabrafenib (Compound)
Sunitinib (Compound) binds MAP2K5 (Gene) and MAP2K5 (Gene) is upregulated by Dabrafenib (Compound)
Sunitinib (Compound) downregu... |
DB00302 | DB04938 | 335 | 1,423 | [
"DDInter1844",
"DDInter1353"
] | Tranexamic acid | Ospemifene | Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986. | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Major | 2 | [
[
[
335,
25,
1423
]
],
[
[
335,
21,
29797
],
[
29797,
60,
1423
]
],
[
[
335,
25,
350
],
[
350,
64,
1423
]
],
[
[
335,
25,
11
],
[
11,
... | [
[
[
"Tranexamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ospemifene"
]
],
[
[
"Tranexamic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Deep vein thrombosis"
],
[
"Deep vein thrombosis",
"{u} (Sid... | Tranexamic acid (Compound) causes Deep vein thrombosis (Side Effect) and Deep vein thrombosis (Side Effect) is caused by Ospemifene (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib may lead to a major life threatening interaction when taken with Osp... |
DB00582 | DB06616 | 1,622 | 594 | [
"DDInter1946",
"DDInter224"
] | Voriconazole | Bosutinib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1622,
25,
594
]
],
[
[
1622,
63,
883
],
[
883,
1,
594
]
],
[
[
1622,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1622,
21,
29231
],
[
29231,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitini... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Voriconazole (Compound) causes Cardiac disorder (Side Effect) and ... |
DB00812 | DB08896 | 998 | 292 | [
"DDInter1451",
"DDInter1576"
] | Phenylbutazone | Regorafenib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
998,
25,
292
]
],
[
[
998,
63,
79
],
[
79,
1,
292
]
],
[
[
998,
6,
6017
],
[
6017,
45,
292
]
],
[
[
998,
24,
1135
],
[
1135,
62,... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
"So... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Phenylbutazone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Phenylbutazone may cause a moderate interaction that could... |
DB01097 | DB08908 | 1,377 | 713 | [
"DDInter1033",
"DDInter564"
] | Leflunomide | Dimethyl fumarate | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Major | 2 | [
[
[
1377,
25,
713
]
],
[
[
1377,
25,
996
],
[
996,
24,
713
]
],
[
[
1377,
64,
1083
],
[
1083,
24,
713
]
],
[
[
1377,
25,
725
],
[
725,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
],
[
"Bedaquiline",
... | Leflunomide may lead to a major life threatening interaction when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Leflunomide may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine may cause ... |
DB00694 | DB00734 | 51 | 1,664 | [
"DDInter485",
"DDInter1605"
] | Daunorubicin | Risperidone | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
51,
24,
1664
]
],
[
[
51,
25,
924
],
[
924,
40,
1664
]
],
[
[
51,
24,
519
],
[
519,
40,
1664
]
],
[
[
51,
6,
4973
],
[
4973,
45,... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
],
[
"Ilop... | Daunorubicin may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Risperidone (Compound)
Dau... |
DB00295 | DB00719 | 475 | 1,219 | [
"DDInter1244",
"DDInter149"
] | Morphine | Azatadine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
475,
24,
1219
]
],
[
[
475,
24,
13
],
[
13,
24,
1219
]
],
[
[
475,
24,
830
],
[
830,
1,
1219
]
],
[
[
475,
25,
695
],
[
695,
24,... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and P... |
DB00204 | DB00836 | 228 | 543 | [
"DDInter580",
"DDInter1088"
] | Dofetilide | Loperamide | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
228,
24,
543
]
],
[
[
228,
25,
888
],
[
888,
24,
543
]
],
[
[
228,
6,
8374
],
[
8374,
45,
543
]
],
[
[
228,
21,
28722
],
[
28722,
... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
],
[
"Tamoxifen",... | Dofetilide may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Dofetilide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Loperamide (Compound)
Dofetilide (Compound) causes Nausea... |
DB00818 | DB06282 | 898 | 516 | [
"DDInter1538",
"DDInter1053"
] | Propofol | Levocetirizine | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
898,
24,
516
]
],
[
[
898,
62,
1031
],
[
1031,
23,
516
]
],
[
[
898,
24,
407
],
[
407,
63,
516
]
],
[
[
898,
24,
770
],
[
770,
2... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Propofol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Theophylline"
],
[
... | Propofol may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Levocetirizine
Propofol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may c... |
DB00321 | DB00501 | 21 | 752 | [
"DDInter78",
"DDInter380"
] | Amitriptyline | Cimetidine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Moderate | 1 | [
[
[
21,
24,
752
]
],
[
[
21,
6,
4973
],
[
4973,
45,
752
]
],
[
[
21,
21,
29551
],
[
29551,
60,
752
]
],
[
[
21,
23,
112
],
[
112,
62... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Amitriptyline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound)
Amitriptyline (Compound) causes Block heart (Side Effect) and Block heart (Side Effect) is caused by Cimetidine (Compound)
Amitriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidaz... |
DB00562 | DB00736 | 1,014 | 660 | [
"DDInter188",
"DDInter676"
] | Benzthiazide | Esomeprazole | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Moderate | 1 | [
[
[
1014,
24,
660
]
],
[
[
1014,
63,
1215
],
[
1215,
40,
660
]
],
[
[
1014,
24,
379
],
[
379,
40,
660
]
],
[
[
1014,
63,
837
],
[
837,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Esomeprazole (Compound)
Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole (Compound) resembles Esomeprazo... |
DB00987 | DB01155 | 1,224 | 872 | [
"DDInter460",
"DDInter813"
] | Cytarabine | Gemifloxacin | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Minor | 0 | [
[
[
1224,
23,
872
]
],
[
[
1224,
62,
739
],
[
739,
1,
872
]
],
[
[
1224,
23,
956
],
[
956,
1,
872
]
],
[
[
1224,
23,
945
],
[
945,
4... | [
[
[
"Cytarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Cytarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Cytarabine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Cytarabine may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) resembles Gemifloxacin (Comp... |
DB00734 | DB06292 | 1,664 | 549 | [
"DDInter1605",
"DDInter474"
] | Risperidone | Dapagliflozin | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1664,
24,
549
]
],
[
[
1664,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1664,
6,
8374
],
[
8374,
45,
549
]
],
[
[
1664,
21,
29222
],
[
29222... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Risperidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Risperidone (Compound) causes Hypoglycaemia (Side Ef... |
DB00557 | DB00986 | 252 | 1,192 | [
"DDInter895",
"DDInter834"
] | Hydroxyzine | Glycopyrronium | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
252,
24,
1192
]
],
[
[
252,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
252,
24,
262
],
[
262,
24,
1192
]
],
[
[
252,
21,
28787
],
[
28787,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and... |
DB01403 | DB11827 | 9 | 433 | [
"DDInter1175",
"DDInter669"
] | Methotrimeprazine | Ertugliflozin | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
9,
24,
433
]
],
[
[
9,
63,
959
],
[
959,
24,
433
]
],
[
[
9,
1,
820
],
[
820,
24,
433
]
],
[
[
9,
40,
1630
],
[
1630,
24,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"... | Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Methotrimeprazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate inter... |
DB01075 | DB01203 | 1,376 | 699 | [
"DDInter569",
"DDInter1255"
] | Diphenhydramine | Nadolol | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
1376,
24,
699
]
],
[
[
1376,
24,
729
],
[
729,
1,
699
]
],
[
[
1376,
63,
887
],
[
887,
1,
699
]
],
[
[
1376,
21,
28722
],
[
28722,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
],
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Nadolol (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Nadolol (Compound)
... |
DB00295 | DB01115 | 475 | 336 | [
"DDInter1244",
"DDInter1291"
] | Morphine | Nifedipine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
475,
24,
336
]
],
[
[
475,
63,
1428
],
[
1428,
1,
336
]
],
[
[
475,
24,
1081
],
[
1081,
40,
336
]
],
[
[
475,
24,
376
],
[
376,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nifedipine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine (Compound)
Mo... |
DB00332 | DB01085 | 1,089 | 562 | [
"DDInter970",
"DDInter1465"
] | Ipratropium | Pilocarpine | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, i... | Moderate | 1 | [
[
[
1089,
24,
562
]
],
[
[
1089,
6,
7992
],
[
7992,
45,
562
]
],
[
[
1089,
18,
10375
],
[
10375,
57,
562
]
],
[
[
1089,
21,
28847
],
[
288... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pilocarpine"
]
],
[
[
"Ipratropium",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)"... | Ipratropium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Pilocarpine (Compound)
Ipratropium (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Pilocarpine (Compound)
Ipratropium (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Pilocarpine (... |
DB00196 | DB09020 | 600 | 28 | [
"DDInter743",
"DDInter212"
] | Fluconazole | Bisacodyl | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
600,
24,
28
]
],
[
[
600,
18,
5546
],
[
5546,
46,
28
]
],
[
[
600,
18,
7710
],
[
7710,
57,
28
]
],
[
[
600,
21,
28666
],
[
28666,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Fluconazole",
"{u} (Compound) downregulates {v} (Gene)",
"HOXA5"
],
[
"HOXA5",
"{u} (Gene) is upregulated by {v}... | Fluconazole (Compound) downregulates HOXA5 (Gene) and HOXA5 (Gene) is upregulated by Bisacodyl (Compound)
Fluconazole (Compound) downregulates ABCF3 (Gene) and ABCF3 (Gene) is downregulated by Bisacodyl (Compound)
Fluconazole (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effe... |
DB09104 | DB11915 | 286 | 1,293 | [
"DDInter1118",
"DDInter1909"
] | Magnesium hydroxide | Valbenazine | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
286,
24,
1293
]
],
[
[
286,
63,
521
],
[
521,
24,
1293
]
],
[
[
286,
62,
401
],
[
401,
24,
1293
]
],
[
[
286,
24,
927
],
[
927,
... | [
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gosereli... | Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Promet... |
DB00011 | DB00039 | 1,451 | 1,253 | [
"DDInter944",
"DDInter1380"
] | Interferon alfa-n1 | Palifermin | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Moderate | 1 | [
[
[
1451,
24,
1253
]
],
[
[
1451,
24,
1488
],
[
1488,
63,
1253
]
],
[
[
1451,
25,
1101
],
[
1101,
63,
1253
]
],
[
[
1451,
24,
268
],
[
268... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palifermin"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Palifermin
Interferon alfa-n1 may lead to a major life threatening interaction when taken with Bexarotene and Bex... |
DB00197 | DB01309 | 1,324 | 1,254 | [
"DDInter1881",
"DDInter933"
] | Troglitazone | Insulin glulisine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1324,
24,
1254
]
],
[
[
1324,
62,
333
],
[
333,
23,
1254
]
],
[
[
1324,
23,
1103
],
[
1103,
23,
1254
]
],
[
[
1324,
24,
1033
],
[
1033... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lipoic acid"
]... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Lipoic acid and Lipoic acid may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Amcinonide and... |
DB00308 | DB06595 | 347 | 1,491 | [
"DDInter901",
"DDInter1214"
] | Ibutilide | Midostaurin | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
347,
25,
1491
]
],
[
[
347,
23,
112
],
[
112,
23,
1491
]
],
[
[
347,
25,
888
],
[
888,
24,
1491
]
],
[
[
347,
24,
657
],
[
657,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Ibutilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Ibutilide may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a... |
DB00377 | DB01242 | 1,494 | 1,237 | [
"DDInter1382",
"DDInter410"
] | Palonosetron | Clomipramine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Major | 2 | [
[
[
1494,
25,
1237
]
],
[
[
1494,
25,
684
],
[
684,
1,
1237
]
],
[
[
1494,
24,
1630
],
[
1630,
1,
1237
]
],
[
[
1494,
24,
401
],
[
401,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomipramine"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thioridazine",
... | Palonosetron may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Clomipramine (Compound)... |
DB00572 | DB01227 | 85 | 1,301 | [
"DDInter136",
"DDInter1043"
] | Atropine | Levacetylmethadol | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Moderate | 1 | [
[
[
85,
24,
1301
]
],
[
[
85,
63,
494
],
[
494,
1,
1301
]
],
[
[
85,
24,
675
],
[
675,
1,
1301
]
],
[
[
85,
24,
1511
],
[
1511,
63,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles... |
DB00889 | DB01035 | 1,133 | 1,401 | [
"DDInter840",
"DDInter1524"
] | Granisetron | Procainamide | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | A derivative of procaine with less CNS action. | Major | 2 | [
[
[
1133,
25,
1401
]
],
[
[
1133,
6,
12523
],
[
12523,
45,
1401
]
],
[
[
1133,
21,
28658
],
[
28658,
60,
1401
]
],
[
[
1133,
23,
112
],
[
... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procainamide"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Pro... | Granisetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Procainamide (Compound)
Granisetron (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Procainamide (Compound)
Granisetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole an... |
DB00495 | DB09054 | 139 | 384 | [
"DDInter1961",
"DDInter905"
] | Zidovudine | Idelalisib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
139,
24,
384
]
],
[
[
139,
24,
328
],
[
328,
24,
384
]
],
[
[
139,
63,
58
],
[
58,
24,
384
]
],
[
[
139,
64,
1101
],
[
1101,
24,... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
],
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and... |
DB01041 | DB08860 | 770 | 788 | [
"DDInter1789",
"DDInter1479"
] | Thalidomide | Pitavastatin | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
770,
24,
788
]
],
[
[
770,
24,
671
],
[
671,
1,
788
]
],
[
[
770,
24,
700
],
[
700,
40,
788
]
],
[
[
770,
6,
6017
],
[
6017,
45,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin... |
DB00781 | DB01135 | 1,481 | 648 | [
"DDInter1489",
"DDInter590"
] | Polymyxin B | Doxacurium | Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram... | Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. | Major | 2 | [
[
[
1481,
25,
648
]
],
[
[
1481,
25,
1319
],
[
1319,
40,
648
]
],
[
[
1481,
1,
1441
],
[
1441,
24,
648
]
],
[
[
1481,
63,
91
],
[
91,
... | [
[
[
"Polymyxin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxacurium"
]
],
[
[
"Polymyxin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mivacurium"
],
[
"Mivacurium",
"{u}... | Polymyxin B may lead to a major life threatening interaction when taken with Mivacurium and Mivacurium (Compound) resembles Doxacurium (Compound)
Polymyxin B (Compound) resembles Bacitracin (Compound) and Bacitracin may cause a moderate interaction that could exacerbate diseases when taken with Doxacurium
Polymyxin B m... |
DB00247 | DB09046 | 1,131 | 1,094 | [
"DDInter1194",
"DDInter1201"
] | Methysergide | Metreleptin | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
1131,
24,
1094
]
],
[
[
1131,
40,
588
],
[
588,
24,
1094
]
],
[
[
1131,
24,
578
],
[
578,
24,
1094
]
],
[
[
1131,
24,
927
],
[
927,
... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Methysergide",
"{u} (Compound) resembles {v} (Compound)",
"Methylergometrine"
],
[
"Methylergometrine",
"{u} ... | Methysergide (Compound) resembles Methylergometrine (Compound) and Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin
Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate int... |
DB05679 | DB12159 | 1,683 | 12 | [
"DDInter1907",
"DDInter609"
] | Ustekinumab | Dupilumab | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | Moderate | 1 | [
[
[
1683,
24,
12
]
],
[
[
1683,
62,
1461
],
[
1461,
23,
12
]
],
[
[
1683,
23,
1114
],
[
1114,
23,
12
]
],
[
[
1683,
63,
599
],
[
599,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dupilumab"
]
],
[
[
"Ustekinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Dupilumab
Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfat... |
DB00182 | DB05812 | 80 | 1,374 | [
"DDInter84",
"DDInter8"
] | Amphetamine | Abiraterone | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
80,
24,
1374
]
],
[
[
80,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
80,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
80,
24,
760
],
[
760,
... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Amphetamine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Amphetamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Amphetamine (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Amphetamine may cause a moderate interaction that could exacerbate diseases wh... |
DB01118 | DB01268 | 33 | 1,151 | [
"DDInter76",
"DDInter1731"
] | Amiodarone | Sunitinib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
33,
25,
1151
]
],
[
[
33,
18,
2284
],
[
2284,
45,
1151
]
],
[
[
33,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
33,
7,
9650
],
[
9650,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Amiodarone",
"{u} (Compound) downregulates {v} (Gene)",
"PRPF4"
],
[
"PRPF4",
"{u} (Gene) is bound by {v} (Compound)",
"Su... | Amiodarone (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is bound by Sunitinib (Compound)
Amiodarone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Amiodarone (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Sunitinib (Compound)
Amiodarone (Compound) dow... |
DB00069 | DB01095 | 367 | 671 | [
"DDInter946",
"DDInter769"
] | Interferon alfacon-1 | Fluvastatin | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Moderate | 1 | [
[
[
367,
24,
671
]
],
[
[
367,
24,
788
],
[
788,
40,
671
]
],
[
[
367,
24,
14
],
[
14,
63,
671
]
],
[
[
367,
24,
126
],
[
126,
23,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitava... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a mo... |
DB00193 | DB06282 | 534 | 516 | [
"DDInter1841",
"DDInter1053"
] | Tramadol | Levocetirizine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
534,
24,
516
]
],
[
[
534,
25,
1031
],
[
1031,
23,
516
]
],
[
[
534,
24,
701
],
[
701,
24,
516
]
],
[
[
534,
25,
407
],
[
407,
6... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Theophylline"
],
[
"Theophyl... | Tramadol may lead to a major life threatening interaction when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Levocetirizine
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may caus... |
DB09272 | DB11160 | 412 | 337 | [
"DDInter632",
"DDInter1459"
] | Eluxadoline | Phenyltoloxamine | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
412,
24,
337
]
],
[
[
412,
63,
820
],
[
820,
24,
337
]
],
[
[
412,
24,
407
],
[
407,
24,
337
]
],
[
[
412,
63,
820
],
[
820,
23,... | [
[
[
"Eluxadoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Eluxadoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],... | Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Opium and O... |
DB00092 | DB14811 | 58 | 385 | [
"DDInter40",
"DDInter979"
] | Alefacept | Isatuximab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
58,
24,
385
]
],
[
[
58,
24,
1362
],
[
1362,
24,
385
]
],
[
[
58,
63,
599
],
[
599,
24,
385
]
],
[
[
58,
24,
908
],
[
908,
25,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab... |
DB01234 | DB04865 | 1,220 | 4 | [
"DDInter513",
"DDInter1335"
] | Dexamethasone | Omacetaxine mepesuccinate | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1220,
24,
4
]
],
[
[
1220,
18,
11089
],
[
11089,
46,
4
]
],
[
[
1220,
7,
2384
],
[
2384,
46,
4
]
],
[
[
1220,
6,
1899
],
[
1899,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Dexamethasone",
"{u} (Compound) downregulates {v} (Gene)",
"DUSP8"
],
[
"DUSP8",
"{u} (Gene) i... | Dexamethasone (Compound) downregulates DUSP8 (Gene) and DUSP8 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Dexamethasone (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Dexamethasone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is upregulated ... |
DB00604 | DB06636 | 1,425 | 1,623 | [
"DDInter385",
"DDInter980"
] | Cisapride | Isavuconazonium | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Major | 2 | [
[
[
1425,
25,
1623
]
],
[
[
1425,
25,
1419
],
[
1419,
24,
1623
]
],
[
[
1425,
24,
543
],
[
543,
24,
1623
]
],
[
[
1425,
64,
1424
],
[
1424... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Imatinib"
],
[
"Imatinib",
"{u} ma... | Cisapride may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a... |
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