drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01253 | DB12332 | 628 | 1,619 | [
"DDInter664",
"DDInter1626"
] | Ergometrine | Rucaparib | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
628,
24,
1619
]
],
[
[
628,
63,
1419
],
[
1419,
24,
1619
]
],
[
[
628,
24,
1213
],
[
1213,
24,
1619
]
],
[
[
628,
24,
159
],
[
159,
... | [
[
[
"Ergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Ergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Ergometrine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Ergometrine may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib ... |
DB01229 | DB12015 | 973 | 1,033 | [
"DDInter1378",
"DDInter53"
] | Paclitaxel (protein-bound) | Alpelisib | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
973,
24,
1033
]
],
[
[
973,
24,
738
],
[
738,
24,
1033
]
],
[
[
973,
63,
10
],
[
10,
24,
1033
]
],
[
[
973,
25,
1510
],
[
1510,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Paclitaxel may... |
DB00631 | DB01268 | 372 | 1,151 | [
"DDInter405",
"DDInter1731"
] | Clofarabine | Sunitinib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
372,
24,
1151
]
],
[
[
372,
7,
14278
],
[
14278,
45,
1151
]
],
[
[
372,
6,
17404
],
[
17404,
45,
1151
]
],
[
[
372,
7,
13230
],
[
1323... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Clofarabine",
"{u} (Compound) upregulates {v} (Gene)",
"PHKG2"
],
[
"PHKG2",
"{u} (Gene) is bound by {v} (Compou... | Clofarabine (Compound) upregulates PHKG2 (Gene) and PHKG2 (Gene) is bound by Sunitinib (Compound)
Clofarabine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Sunitinib (Compound)
Clofarabine (Compound) upregulates TIPARP (Gene) and TIPARP (Gene) is upregulated by Sunitinib (Compound)
Clofarabine (Compound) d... |
DB01100 | DB06691 | 1,568 | 849 | [
"DDInter1470",
"DDInter1155"
] | Pimozide | Mepyramine | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1568,
24,
849
]
],
[
[
1568,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1568,
24,
272
],
[
272,
24,
849
]
],
[
[
1568,
6,
12523
],
[
12523,
... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlo... |
DB11730 | DB11932 | 351 | 327 | [
"DDInter1588",
"DDInter3"
] | Ribociclib | Abametapir (topical) | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
351,
24,
327
]
],
[
[
351,
25,
124
],
[
124,
63,
327
]
],
[
[
351,
23,
283
],
[
283,
63,
327
]
],
[
[
351,
63,
1601
],
[
1601,
2... | [
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Ribociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
],
[
"Glasdegib",... | Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Ribociclib may lead to a major life threatening interaction when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Ribociclib may cause a mino... |
DB00777 | DB01362 | 146 | 497 | [
"DDInter1537",
"DDInter960"
] | Propiomazine | Iohexol | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
146,
25,
497
]
],
[
[
146,
63,
530
],
[
530,
25,
497
]
],
[
[
146,
24,
1264
],
[
1264,
25,
497
]
],
[
[
146,
40,
1237
],
[
1237,
... | [
[
[
"Propiomazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
[
"Dronabino... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may lead to a major life threatening interaction when taken with Iohexol
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may lead to a m... |
DB06186 | DB09276 | 1,439 | 381 | [
"DDInter969",
"DDInter1682"
] | Ipilimumab | Sodium aurothiomalate | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
1439,
24,
381
]
],
[
[
1439,
63,
491
],
[
491,
24,
381
]
],
[
[
1439,
24,
1626
],
[
1626,
24,
381
]
],
[
[
1439,
24,
1480
],
[
1480,
... | [
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon al... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Ipilimumab may cause a moderate interaction that could exacerbate diseases when... |
DB00374 | DB00800 | 1,061 | 572 | [
"DDInter1852",
"DDInter720"
] | Treprostinil | Fenoldopam | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. | Moderate | 1 | [
[
[
1061,
24,
572
]
],
[
[
1061,
21,
28931
],
[
28931,
60,
572
]
],
[
[
1061,
24,
274
],
[
274,
24,
572
]
],
[
[
1061,
63,
1648
],
[
1648,... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenoldopam"
]
],
[
[
"Treprostinil",
"{u} (Compound) causes {v} (Side Effect)",
"Haemorrhage"
],
[
"Haemorrhage",
"{u} (Side Effect)... | Treprostinil (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Fenoldopam (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and Phentolamine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB11703 | DB12130 | 405 | 1,017 | [
"DDInter9",
"DDInter1094"
] | Acalabrutinib | Lorlatinib | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
405,
24,
1017
]
],
[
[
405,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
405,
64,
976
],
[
976,
24,
1017
]
],
[
[
405,
25,
1421
],
[
1421,
... | [
[
[
"Acalabrutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Acalabrutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Acalabrutinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Acalabrutinib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may ... |
DB01197 | DB11691 | 1,603 | 1,499 | [
"DDInter292",
"DDInter1258"
] | Captopril | Naldemedine | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
1603,
24,
1499
]
],
[
[
1603,
63,
267
],
[
267,
24,
1499
]
],
[
[
1603,
25,
1456
],
[
1456,
24,
1499
]
],
[
[
1603,
24,
1220
],
[
1220... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Captopril may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax may cause a... |
DB01177 | DB10316 | 77 | 334 | [
"DDInter904",
"DDInter1248"
] | Idarubicin | Mumps virus strain B level jeryl lynn live antigen | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
77,
25,
334
]
],
[
[
77,
64,
1057
],
[
1057,
25,
334
]
],
[
[
77,
63,
328
],
[
328,
25,
334
]
],
[
[
77,
25,
908
],
[
908,
25,
... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
]... | Idarubicin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopur... |
DB00014 | DB04865 | 521 | 4 | [
"DDInter839",
"DDInter1335"
] | Goserelin | Omacetaxine mepesuccinate | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
521,
24,
4
]
],
[
[
521,
24,
770
],
[
770,
24,
4
]
],
[
[
521,
24,
1250
],
[
1250,
63,
4
]
],
[
[
521,
25,
11
],
[
11,
24,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Pazopa... |
DB00902 | DB01173 | 104 | 358 | [
"DDInter1168",
"DDInter1349"
] | Methdilazine | Orphenadrine | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Moderate | 1 | [
[
[
104,
24,
358
]
],
[
[
104,
24,
211
],
[
211,
1,
358
]
],
[
[
104,
24,
272
],
[
272,
24,
358
]
],
[
[
104,
1,
293
],
[
293,
40,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Orphenadrine (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate in... |
DB00497 | DB05812 | 828 | 1,374 | [
"DDInter1366",
"DDInter8"
] | Oxycodone | Abiraterone | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Major | 2 | [
[
[
828,
25,
1374
]
],
[
[
828,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
828,
21,
28809
],
[
28809,
60,
1374
]
],
[
[
828,
25,
760
],
[
760,... | [
[
[
"Oxycodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
]
],
[
[
"Oxycodone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Abirater... | Oxycodone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Oxycodone (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Oxycodone may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause... |
DB06788 | DB11986 | 1,616 | 484 | [
"DDInter864",
"DDInter648"
] | Histrelin | Entrectinib | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1616,
24,
484
]
],
[
[
1616,
62,
1247
],
[
1247,
23,
484
]
],
[
[
1616,
63,
1539
],
[
1539,
24,
484
]
],
[
[
1616,
24,
1662
],
[
1662,... | [
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Histrelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[... | Histrelin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and ... |
DB01406 | DB09049 | 984 | 1,135 | [
"DDInter472",
"DDInter1261"
] | Danazol | Naloxegol | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Major | 2 | [
[
[
984,
25,
1135
]
],
[
[
984,
24,
971
],
[
971,
62,
1135
]
],
[
[
984,
24,
478
],
[
478,
23,
1135
]
],
[
[
984,
63,
392
],
[
392,
... | [
[
[
"Danazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
]
],
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
[
"Gilteritinib",
... | Danazol may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib ma... |
DB00401 | DB11901 | 84 | 913 | [
"DDInter1298",
"DDInter107"
] | Nisoldipine | Apalutamide | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
84,
25,
913
]
],
[
[
84,
63,
600
],
[
600,
24,
913
]
],
[
[
84,
24,
1619
],
[
1619,
63,
913
]
],
[
[
84,
24,
1450
],
[
1450,
24,... | [
[
[
"Nisoldipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
"Flucon... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ru... |
DB00005 | DB08826 | 1,057 | 1,292 | [
"DDInter687",
"DDInter489"
] | Etanercept | Deferiprone | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1057,
25,
1292
]
],
[
[
1057,
24,
45
],
[
45,
24,
1292
]
],
[
[
1057,
23,
1193
],
[
1193,
63,
1292
]
],
[
[
1057,
25,
482
],
[
482,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
],
[
"Didanosin... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zin... |
DB09280 | DB09381 | 1,604 | 192 | [
"DDInter1101",
"DDInter678"
] | Lumacaftor | Esterified estrogens | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1604,
24,
192
]
],
[
[
1604,
25,
1019
],
[
1019,
63,
192
]
],
[
[
1604,
63,
1547
],
[
1547,
24,
192
]
],
[
[
1604,
64,
868
],
[
868,
... | [
[
[
"Lumacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
],
[
... | Lumacaftor may lead to a major life threatening interaction when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Lumacaftor may cause a moderate interaction that could exacerbate diseases when taken with Exemestane and Exemestan... |
DB00365 | DB09073 | 839 | 951 | [
"DDInter842",
"DDInter1379"
] | Grepafloxacin | Palbociclib | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
839,
24,
951
]
],
[
[
839,
24,
1476
],
[
1476,
63,
951
]
],
[
[
839,
24,
467
],
[
467,
24,
951
]
],
[
[
839,
62,
134
],
[
134,
2... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin an... |
DB09118 | DB12010 | 1,580 | 214 | [
"DDInter1711",
"DDInter785"
] | Stiripentol | Fostamatinib | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1580,
24,
214
]
],
[
[
1580,
63,
976
],
[
976,
24,
214
]
],
[
[
1580,
64,
866
],
[
866,
24,
214
]
],
[
[
1580,
24,
676
],
[
676,
... | [
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
... | Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Stiripentol may lead to a major life threatening interaction when taken with Cobimetinib and Cobimetinib ma... |
DB00812 | DB12941 | 998 | 466 | [
"DDInter1451",
"DDInter481"
] | Phenylbutazone | Darolutamide | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
998,
24,
466
]
],
[
[
998,
24,
351
],
[
351,
23,
466
]
],
[
[
998,
63,
723
],
[
723,
23,
466
]
],
[
[
998,
24,
159
],
[
159,
62,... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant an... |
DB00358 | DB01035 | 1,010 | 1,401 | [
"DDInter1140",
"DDInter1524"
] | Mefloquine | Procainamide | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | A derivative of procaine with less CNS action. | Major | 2 | [
[
[
1010,
25,
1401
]
],
[
[
1010,
23,
1311
],
[
1311,
63,
1401
]
],
[
[
1010,
6,
12523
],
[
12523,
45,
1401
]
],
[
[
1010,
21,
28658
],
[
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procainamide"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metoclopramide"
],
[
"Metocl... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Procainamide
Mefloquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Procainamide (Compound)
Mefloqui... |
DB00912 | DB01259 | 473 | 392 | [
"DDInter1581",
"DDInter1024"
] | Repaglinide | Lapatinib | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
473,
24,
392
]
],
[
[
473,
6,
8374
],
[
8374,
45,
392
]
],
[
[
473,
21,
28852
],
[
28852,
60,
392
]
],
[
[
473,
24,
1247
],
[
1247,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Repaglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Repaglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Repaglinide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Lapatinib (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole... |
DB00390 | DB11363 | 1,252 | 1,276 | [
"DDInter554",
"DDInter39"
] | Digoxin | Alectinib | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
1252,
24,
1276
]
],
[
[
1252,
1,
1482
],
[
1482,
24,
1276
]
],
[
[
1252,
25,
1011
],
[
1011,
24,
1276
]
],
[
[
1252,
24,
1424
],
[
142... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Digoxin",
"{u} (Compound) resembles {v} (Compound)",
"Digitoxin"
],
[
"Digitoxin",
"{u} may cause a moderate interac... | Digoxin (Compound) resembles Digitoxin (Compound) and Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Digoxin may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases whe... |
DB00197 | DB00852 | 1,324 | 1,445 | [
"DDInter1881",
"DDInter1545"
] | Troglitazone | Pseudoephedrine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
1324,
24,
1445
]
],
[
[
1324,
63,
73
],
[
73,
24,
1445
]
],
[
[
1324,
24,
22
],
[
22,
40,
1445
]
],
[
[
1324,
24,
761
],
[
761,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
]... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine ... |
DB00647 | DB11718 | 675 | 927 | [
"DDInter528",
"DDInter640"
] | Dextropropoxyphene | Encorafenib | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
675,
24,
927
]
],
[
[
675,
23,
112
],
[
112,
23,
927
]
],
[
[
675,
24,
720
],
[
720,
24,
927
]
],
[
[
675,
40,
998
],
[
998,
24,... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazol... | Dextropropoxyphene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mi... |
DB00939 | DB01099 | 1,338 | 1,272 | [
"DDInter1135",
"DDInter744"
] | Meclofenamic acid | Flucytosine | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
1338,
24,
1272
]
],
[
[
1338,
21,
29209
],
[
29209,
60,
1272
]
],
[
[
1338,
24,
1448
],
[
1448,
24,
1272
]
],
[
[
1338,
63,
599
],
[
5... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Meclofenamic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Ef... | Meclofenamic acid (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Flucytosine (Compound)
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when t... |
DB00261 | DB00647 | 702 | 675 | [
"DDInter93",
"DDInter528"
] | Anagrelide | Dextropropoxyphene | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Major | 2 | [
[
[
702,
25,
675
]
],
[
[
702,
25,
888
],
[
888,
64,
675
]
],
[
[
702,
25,
494
],
[
494,
1,
675
]
],
[
[
702,
25,
1301
],
[
1301,
40... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
],
[
"Tamoxifen",
... | Anagrelide may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may lead to a major life threatening interaction when taken with Dextropropoxyphene
Anagrelide may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Dextropro... |
DB00278 | DB10672 | 291 | 297 | [
"DDInter117",
"DDInter417"
] | Argatroban | Clove | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
291,
23,
297
]
],
[
[
291,
25,
235
],
[
235,
62,
297
]
],
[
[
291,
24,
578
],
[
578,
23,
297
]
],
[
[
291,
25,
1564
],
[
1564,
2... | [
[
[
"Argatroban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
... | Argatroban may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor i... |
DB00312 | DB00719 | 1,023 | 1,219 | [
"DDInter1423",
"DDInter149"
] | Pentobarbital | Azatadine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1023,
24,
1219
]
],
[
[
1023,
24,
13
],
[
13,
24,
1219
]
],
[
[
1023,
24,
830
],
[
830,
1,
1219
]
],
[
[
1023,
6,
8374
],
[
8374,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Pheninda... |
DB01081 | DB11915 | 1,688 | 1,293 | [
"DDInter571",
"DDInter1909"
] | Diphenoxylate | Valbenazine | A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Subst... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1688,
24,
1293
]
],
[
[
1688,
24,
516
],
[
516,
24,
1293
]
],
[
[
1688,
63,
1242
],
[
1242,
24,
1293
]
],
[
[
1688,
40,
1118
],
[
1118... | [
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
... | Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Cetiri... |
DB00280 | DB00836 | 494 | 543 | [
"DDInter575",
"DDInter1088"
] | Disopyramide | Loperamide | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
494,
24,
543
]
],
[
[
494,
1,
11392
],
[
11392,
40,
543
]
],
[
[
494,
1,
675
],
[
675,
24,
543
]
],
[
[
494,
40,
649
],
[
649,
1... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Disopyramide",
"{u} (Compound) resembles {v} (Compound)",
"Methadyl Acetate"
],
[
"Methadyl Acetate",
"{u} (Co... | Disopyramide (Compound) resembles Methadyl Acetate (Compound) and Methadyl Acetate (Compound) resembles Loperamide (Compound)
Disopyramide (Compound) resembles Dextropropoxyphene (Compound) and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Disopyramide (Co... |
DB01233 | DB06691 | 1,311 | 849 | [
"DDInter1197",
"DDInter1155"
] | Metoclopramide | Mepyramine | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1311,
24,
849
]
],
[
[
1311,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1311,
6,
12523
],
[
12523,
45,
849
]
],
[
[
1311,
24,
1536
],
[
1536... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Metoclopramide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Metoclopra... |
DB00486 | DB00962 | 1,614 | 1,639 | [
"DDInter1253",
"DDInter1957"
] | Nabilone | Zaleplon | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. | Moderate | 1 | [
[
[
1614,
24,
1639
]
],
[
[
1614,
21,
28898
],
[
28898,
60,
1639
]
],
[
[
1614,
63,
13
],
[
13,
24,
1639
]
],
[
[
1614,
24,
1609
],
[
1609... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zaleplon"
]
],
[
[
"Nabilone",
"{u} (Compound) causes {v} (Side Effect)",
"Constipation"
],
[
"Constipation",
"{u} (Side Effect) is caus... | Nabilone (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Zaleplon (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00635 | DB01336 | 1,573 | 545 | [
"DDInter1515",
"DDInter1198"
] | Prednisone | Metocurine | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine. | Moderate | 1 | [
[
[
1573,
24,
545
]
],
[
[
1573,
24,
1217
],
[
1217,
40,
545
]
],
[
[
1573,
63,
1031
],
[
1031,
24,
545
]
],
[
[
1573,
1,
1486
],
[
1486,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metocurine"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubocurarine"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Tubocurarine and Tubocurarine (Compound) resembles Metocurine (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction th... |
DB00307 | DB00649 | 1,101 | 231 | [
"DDInter202",
"DDInter1710"
] | Bexarotene | Stavudine | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Major | 2 | [
[
[
1101,
25,
231
]
],
[
[
1101,
25,
139
],
[
139,
1,
231
]
],
[
[
1101,
21,
28810
],
[
28810,
60,
231
]
],
[
[
1101,
25,
375
],
[
375,
... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stavudine"
]
],
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
[
"Zidovudine",
"{u} (C... | Bexarotene may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine (Compound) resembles Stavudine (Compound)
Bexarotene (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Stavudine (Compound)
Bexarotene may lead to a major life t... |
DB00408 | DB00470 | 1,408 | 530 | [
"DDInter1099",
"DDInter601"
] | Loxapine | Dronabinol | An antipsychotic agent used in schizophrenia. [PubChem] | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
1408,
24,
530
]
],
[
[
1408,
24,
1614
],
[
1614,
40,
530
]
],
[
[
1408,
21,
29118
],
[
29118,
60,
530
]
],
[
[
1408,
63,
701
],
[
701,... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
"N... | Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Loxapine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Dronabinol (Compound)
Loxapine may cause a moderate interaction that c... |
DB01320 | DB06605 | 651 | 1,409 | [
"DDInter783",
"DDInter108"
] | Fosphenytoin | Apixaban | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
651,
25,
1409
]
],
[
[
651,
6,
3486
],
[
3486,
45,
1409
]
],
[
[
651,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
651,
40,
307
],
[
307,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Fosphenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Apixa... | Fosphenytoin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Apixaban (Compound)
Fosphenytoin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Fosphenytoin (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can ... |
DB00852 | DB01168 | 1,445 | 1,053 | [
"DDInter1545",
"DDInter1526"
] | Pseudoephedrine | Procarbazine | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
1445,
25,
1053
]
],
[
[
1445,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1445,
63,
1000
],
[
1000,
24,
1053
]
],
[
[
1445,
24,
480
],
[
4... | [
[
[
"Pseudoephedrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Pseudoephedrine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by... | Pseudoephedrine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Guanadrel and Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00030 | DB00860 | 1,685 | 891 | [
"DDInter934",
"DDInter1513"
] | Insulin human | Prednisolone | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1685,
24,
891
]
],
[
[
1685,
24,
989
],
[
989,
1,
891
]
],
[
[
1685,
24,
175
],
[
175,
40,
891
]
],
[
[
1685,
24,
1561
],
[
1561,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
]... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resembles Prednisolone (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Pred... |
DB00285 | DB09075 | 1,100 | 498 | [
"DDInter1927",
"DDInter621"
] | Venlafaxine | Edoxaban | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
1100,
24,
498
]
],
[
[
1100,
25,
222
],
[
222,
24,
498
]
],
[
[
1100,
24,
1017
],
[
1017,
63,
498
]
],
[
[
1100,
24,
129
],
[
129,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Venlafaxine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may caus... |
DB00627 | DB00631 | 265 | 372 | [
"DDInter1286",
"DDInter405"
] | Niacin | Clofarabine | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
265,
24,
372
]
],
[
[
265,
21,
28903
],
[
28903,
60,
372
]
],
[
[
265,
63,
1560
],
[
1560,
24,
372
]
],
[
[
265,
25,
14
],
[
14,
... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Niacin",
"{u} (Compound) causes {v} (Side Effect)",
"Dry skin"
],
[
"Dry skin",
"{u} (Side Effect) is caused by {v}... | Niacin (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Clofarabine (Compound)
Niacin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine
... |
DB00877 | DB01764 | 629 | 805 | [
"DDInter1678",
"DDInter469"
] | Sirolimus | Dalfopristin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Moderate | 1 | [
[
[
629,
24,
805
]
],
[
[
629,
6,
8374
],
[
8374,
45,
805
]
],
[
[
629,
24,
222
],
[
222,
23,
805
]
],
[
[
629,
63,
1101
],
[
1101,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfopristin"
]
],
[
[
"Sirolimus",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dalfopristin (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Sirolimus may ca... |
DB00439 | DB05812 | 289 | 1,374 | [
"DDInter341",
"DDInter8"
] | Cerivastatin | Abiraterone | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
289,
24,
1374
]
],
[
[
289,
24,
466
],
[
466,
62,
1374
]
],
[
[
289,
24,
112
],
[
112,
23,
1374
]
],
[
[
289,
24,
1555
],
[
1555,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Abiraterone
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole ... |
DB00468 | DB01087 | 1,424 | 1,520 | [
"DDInter1557",
"DDInter1520"
] | Quinine | Primaquine | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
1424,
24,
1520
]
],
[
[
1424,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
1424,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
1424,
21,
28722
],
[
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hydroxyc... | Quinine may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Quinine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Quinine (Compound) causes Nausea (Side... |
DB01208 | DB13928 | 945 | 1,385 | [
"DDInter1705",
"DDInter1660"
] | Sparfloxacin | Semaglutide | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
945,
24,
1385
]
],
[
[
945,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
945,
64,
891
],
[
891,
24,
1385
]
],
[
[
945,
40,
872
],
[
872,
... | [
[
[
"Sparfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
"Pasi... | Sparfloxacin may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Sparfloxacin may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may cause a mo... |
DB06589 | DB10795 | 1,250 | 221 | [
"DDInter1400",
"DDInter1486"
] | Pazopanib | Poliovirus type 1 antigen (formaldehyde inactivated) | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
1250,
24,
221
]
],
[
[
1250,
24,
36
],
[
36,
24,
221
]
],
[
[
1250,
64,
581
],
[
581,
24,
221
]
],
[
[
1250,
63,
599
],
[
599,
2... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Pazopanib may lead to a major life threatening interaction when taken with ... |
DB04948 | DB06282 | 1,084 | 516 | [
"DDInter1083",
"DDInter1053"
] | Lofexidine | Levocetirizine | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1084,
24,
516
]
],
[
[
1084,
63,
701
],
[
701,
24,
516
]
],
[
[
1084,
24,
407
],
[
407,
63,
516
]
],
[
[
1084,
40,
1617
],
[
1617,
... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium m... |
DB00880 | DB11057 | 359 | 720 | [
"DDInter360",
"DDInter1223"
] | Chlorothiazide | Mineral oil | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
359,
24,
720
]
],
[
[
359,
63,
175
],
[
175,
24,
720
]
],
[
[
359,
24,
1486
],
[
1486,
24,
720
]
],
[
[
359,
40,
674
],
[
674,
2... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Methyl... |
DB00063 | DB01125 | 366 | 279 | [
"DDInter659",
"DDInter98"
] | Eptifibatide | Anisindione | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Major | 2 | [
[
[
366,
25,
279
]
],
[
[
366,
63,
1595
],
[
1595,
24,
279
]
],
[
[
366,
24,
557
],
[
557,
63,
279
]
],
[
[
366,
24,
222
],
[
222,
2... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
]
],
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Collagenase clostridium histolyticum"... | Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Collagenase clostridium histolyticum and Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Eptifibatide may cause a moderate interaction that could ... |
DB00813 | DB09098 | 704 | 98 | [
"DDInter722",
"DDInter1700"
] | Fentanyl | Somatrem | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
704,
24,
98
]
],
[
[
704,
24,
159
],
[
159,
63,
98
]
],
[
[
704,
25,
609
],
[
609,
24,
98
]
],
[
[
704,
40,
576
],
[
576,
24,
... | [
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Fentanyl may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin ma... |
DB00055 | DB00278 | 834 | 291 | [
"DDInter605",
"DDInter117"
] | Drotrecogin alfa | Argatroban | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Major | 2 | [
[
[
834,
25,
291
]
],
[
[
834,
23,
539
],
[
539,
62,
291
]
],
[
[
834,
24,
972
],
[
972,
63,
291
]
],
[
[
834,
24,
1230
],
[
1230,
2... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Argatroban"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Ca... | Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Argatroban
Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylat... |
DB00983 | DB01118 | 480 | 33 | [
"DDInter776",
"DDInter76"
] | Formoterol | Amiodarone | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
480,
24,
33
]
],
[
[
480,
24,
540
],
[
540,
1,
33
]
],
[
[
480,
6,
8717
],
[
8717,
45,
33
]
],
[
[
480,
7,
5998
],
[
5998,
46,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Formoterol (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Amiodarone (Compound)
Formoterol (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) ... |
DB13874 | DB13879 | 1,501 | 1,043 | [
"DDInter639",
"DDInter824"
] | Enasidenib | Glecaprevir | Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible ... | Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with , glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic ba... | Moderate | 1 | [
[
[
1501,
24,
1043
]
],
[
[
1501,
63,
119
],
[
119,
24,
1043
]
],
[
[
1501,
63,
467
],
[
467,
25,
1043
]
],
[
[
1501,
64,
14
],
[
14,
... | [
[
[
"Enasidenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glecaprevir"
]
],
[
[
"Enasidenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
],
[
... | Enasidenib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib and Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Glecaprevir
Enasidenib may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Si... |
DB00502 | DB00938 | 1,300 | 455 | [
"DDInter853",
"DDInter1635"
] | Haloperidol | Salmeterol | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1300,
24,
455
]
],
[
[
1300,
24,
688
],
[
688,
63,
455
]
],
[
[
1300,
6,
6799
],
[
6799,
45,
455
]
],
[
[
1300,
6,
3769
],
[
3769,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Haloperidol (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Salmeterol (Compound)
Haloperidol (Com... |
DB01044 | DB06699 | 246 | 774 | [
"DDInter809",
"DDInter493"
] | Gatifloxacin | Degarelix | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Major | 2 | [
[
[
246,
25,
774
]
],
[
[
246,
64,
521
],
[
521,
1,
774
]
],
[
[
246,
21,
29232
],
[
29232,
60,
774
]
],
[
[
246,
62,
112
],
[
112,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Degarelix"
]
],
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Goserelin"
],
[
"Goserelin",
"{u} ... | Gatifloxacin may lead to a major life threatening interaction when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Gatifloxacin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Gatifloxacin may cause a minor interaction that can limit c... |
DB00054 | DB00812 | 1,432 | 998 | [
"DDInter6",
"DDInter1451"
] | Abciximab | Phenylbutazone | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Moderate | 1 | [
[
[
1432,
24,
998
]
],
[
[
1432,
24,
97
],
[
97,
40,
998
]
],
[
[
1432,
24,
1061
],
[
1061,
24,
998
]
],
[
[
1432,
63,
942
],
[
942,
... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
],
[
... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) resembles Phenylbutazone (Compound)
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that c... |
DB00574 | DB11703 | 121 | 405 | [
"DDInter717",
"DDInter9"
] | Fenfluramine | Acalabrutinib | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
121,
24,
405
]
],
[
[
121,
63,
1324
],
[
1324,
24,
405
]
],
[
[
121,
25,
643
],
[
643,
24,
405
]
],
[
[
121,
24,
1598
],
[
1598,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Fenfluramine may lead to a major life threatening interaction when taken with Desvenlafaxine and Desven... |
DB00489 | DB01143 | 17 | 923 | [
"DDInter1704",
"DDInter65"
] | Sotalol | Amifostine | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
17,
24,
923
]
],
[
[
17,
21,
28642
],
[
28642,
60,
923
]
],
[
[
17,
24,
714
],
[
714,
24,
923
]
],
[
[
17,
1,
88
],
[
88,
24,
... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Sotalol",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Effect) is caused by {v} (Com... | Sotalol (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Sotalol (Compo... |
DB00889 | DB09083 | 1,133 | 880 | [
"DDInter840",
"DDInter996"
] | Granisetron | Ivabradine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
1133,
25,
880
]
],
[
[
1133,
24,
480
],
[
480,
24,
880
]
],
[
[
1133,
24,
159
],
[
159,
63,
880
]
],
[
[
1133,
63,
1674
],
[
1674,
... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoter... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and L... |
DB00631 | DB06603 | 372 | 39 | [
"DDInter405",
"DDInter1387"
] | Clofarabine | Panobinostat | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
372,
24,
39
]
],
[
[
372,
24,
1247
],
[
1247,
23,
39
]
],
[
[
372,
63,
912
],
[
912,
24,
39
]
],
[
[
372,
24,
221
],
[
221,
63,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
]... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Interfe... |
DB01210 | DB09156 | 668 | 777 | [
"DDInter1050",
"DDInter964"
] | Levobunolol (ophthalmic) | Iopromide | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
668,
24,
777
]
],
[
[
668,
40,
461
],
[
461,
24,
777
]
],
[
[
668,
24,
1013
],
[
1013,
63,
777
]
],
[
[
668,
24,
512
],
[
512,
2... | [
[
[
"Levobunolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Levobunolol",
"{u} (Compound) resembles {v} (Compound)",
"Timolol"
],
[
"Timolol",
"{u} may cause a moderate int... | Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Levobunolol (Compound) resembles Timolol (Compound) and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Levobunolol may cause a moderate interaction that could exacerba... |
DB00049 | DB09112 | 737 | 1,455 | [
"DDInter1573",
"DDInter1306"
] | Rasburicase | Nitrous acid | Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified <i>Saccharomyces cerevisiae</i> strain. The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_. | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Major | 2 | [
[
[
737,
25,
1455
]
],
[
[
737,
25,
490
],
[
490,
25,
1455
]
],
[
[
737,
24,
384
],
[
384,
63,
585
],
[
585,
25,
1455
]
],
[
[
737,
... | [
[
[
"Rasburicase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nitrous acid"
]
],
[
[
"Rasburicase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prilocaine"
],
[
"Prilocaine",
"{... | Rasburicase may lead to a major life threatening interaction when taken with Prilocaine and Prilocaine may lead to a major life threatening interaction when taken with Nitrous acid
Rasburicase may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate ... |
DB00574 | DB11124 | 121 | 209 | [
"DDInter717",
"DDInter1560"
] | Fenfluramine | Racepinephrine | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Racepinephrine is a racemic mixture consisting of d- and l- enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingred... | Moderate | 1 | [
[
[
121,
24,
209
]
],
[
[
121,
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688
],
[
688,
24,
209
]
],
[
[
121,
25,
222
],
[
222,
24,
209
]
],
[
[
121,
63,
542
],
[
542,
24,... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Racepinephrine"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Racepinephrine
Fenfluramine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine ... |
DB00307 | DB12095 | 1,101 | 179 | [
"DDInter202",
"DDInter1760"
] | Bexarotene | Telotristat ethyl | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
1101,
24,
179
]
],
[
[
1101,
24,
79
],
[
79,
24,
179
]
],
[
[
1101,
25,
1517
],
[
1517,
24,
179
]
],
[
[
1101,
24,
283
],
[
283,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Bexarotene may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin m... |
DB00284 | DB06077 | 1,647 | 879 | [
"DDInter11",
"DDInter1102"
] | Acarbose | Lumateperone | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
1647,
24,
879
]
],
[
[
1647,
23,
1645
],
[
1645,
24,
879
]
],
[
[
1647,
24,
999
],
[
999,
24,
879
]
],
[
[
1647,
23,
135
],
[
135,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Acarbose",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metformin"
],
[
"... | Acarbose may cause a minor interaction that can limit clinical effects when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thieth... |
DB00241 | DB08881 | 288 | 868 | [
"DDInter257",
"DDInter1925"
] | Butalbital | Vemurafenib | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
288,
24,
868
]
],
[
[
288,
23,
608
],
[
608,
23,
868
]
],
[
[
288,
24,
112
],
[
112,
23,
868
]
],
[
[
288,
62,
168
],
[
168,
23,... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Butalbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
... | Butalbital may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Vemurafenib
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronid... |
DB00790 | DB09154 | 664 | 1,475 | [
"DDInter1431",
"DDInter1686"
] | Perindopril | Sodium citrate | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Minor | 0 | [
[
[
664,
23,
1475
]
],
[
[
664,
40,
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],
[
610,
23,
1475
]
],
[
[
664,
24,
1411
],
[
1411,
23,
1475
]
],
[
[
664,
1,
954
],
[
954,
... | [
[
[
"Perindopril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium citrate"
]
],
[
[
"Perindopril",
"{u} (Compound) resembles {v} (Compound)",
"Enalapril"
],
[
"Enalapril",
"{u} may cause a minor... | Perindopril (Compound) resembles Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a minor interaction that can ... |
DB06688 | DB09330 | 1,430 | 985 | [
"DDInter1677",
"DDInter1352"
] | Sipuleucel-T | Osimertinib | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1430,
24,
985
]
],
[
[
1430,
63,
168
],
[
168,
23,
985
]
],
[
[
1430,
63,
134
],
[
134,
24,
985
]
],
[
[
1430,
24,
119
],
[
119,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vi... |
DB00653 | DB00827 | 544 | 646 | [
"DDInter1120",
"DDInter383"
] | Magnesium sulfate | Cinoxacin | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Moderate | 1 | [
[
[
544,
24,
646
]
],
[
[
544,
24,
613
],
[
613,
23,
646
]
],
[
[
544,
24,
853
],
[
853,
63,
646
]
],
[
[
544,
24,
1019
],
[
1019,
6... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cinoxacin"
]
],
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
... | Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium ... |
DB01098 | DB08870 | 14 | 850 | [
"DDInter1622",
"DDInter228"
] | Rosuvastatin | Brentuximab vedotin | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
14,
24,
850
]
],
[
[
14,
35,
788
],
[
788,
24,
850
]
],
[
[
14,
63,
671
],
[
671,
24,
850
]
],
[
[
14,
24,
1033
],
[
1033,
63,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Rosuvastatin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases... | Rosuvastatin (Compound) resembles Pitavastatin (Compound) and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Rosuvastatin may cause a moderate i... |
DB00231 | DB01233 | 1,174 | 1,311 | [
"DDInter1761",
"DDInter1197"
] | Temazepam | Metoclopramide | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1174,
24,
1311
]
],
[
[
1174,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
1174,
24,
649
],
[
649,
63,
1311
]
],
[
[
1174,
24,
662
],
[
662... | [
[
[
"Temazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Temazepam",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is ... | Temazepam (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Temazepam may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Met... |
DB00305 | DB11817 | 377 | 1,259 | [
"DDInter1232",
"DDInter165"
] | Mitomycin | Baricitinib | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
377,
25,
1259
]
],
[
[
377,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
377,
24,
949
],
[
949,
24,
1259
]
],
[
[
377,
24,
1129
],
[
1129,
... | [
[
[
"Mitomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid ... |
DB00514 | DB01215 | 506 | 1,418 | [
"DDInter527",
"DDInter677"
] | Dextromethorphan | Estazolam | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
506,
24,
1418
]
],
[
[
506,
63,
523
],
[
523,
1,
1418
]
],
[
[
506,
24,
1216
],
[
1216,
40,
1418
]
],
[
[
506,
63,
905
],
[
905,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (... |
DB00594 | DB09472 | 863 | 1,383 | [
"DDInter68",
"DDInter1693"
] | Amiloride | Sodium sulfate | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
863,
24,
1383
]
],
[
[
863,
24,
104
],
[
104,
24,
1383
]
],
[
[
863,
63,
475
],
[
475,
24,
1383
]
],
[
[
863,
24,
407
],
[
407,
... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Mo... |
DB00358 | DB11363 | 1,010 | 1,276 | [
"DDInter1140",
"DDInter39"
] | Mefloquine | Alectinib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
1010,
24,
1276
]
],
[
[
1010,
24,
819
],
[
819,
24,
1276
]
],
[
[
1010,
63,
88
],
[
88,
24,
1276
]
],
[
[
1010,
25,
1011
],
[
1011,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metopro... |
DB00231 | DB01205 | 1,174 | 1,404 | [
"DDInter1761",
"DDInter748"
] | Temazepam | Flumazenil | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. | Moderate | 1 | [
[
[
1174,
24,
1404
]
],
[
[
1174,
6,
13500
],
[
13500,
45,
1404
]
],
[
[
1174,
21,
29003
],
[
29003,
60,
1404
]
],
[
[
1174,
1,
902
],
[
9... | [
[
[
"Temazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flumazenil"
]
],
[
[
"Temazepam",
"{u} (Compound) binds {v} (Gene)",
"GABRA5"
],
[
"GABRA5",
"{u} (Gene) is bound by {v} (Compound)",
... | Temazepam (Compound) binds GABRA5 (Gene) and GABRA5 (Gene) is bound by Flumazenil (Compound)
Temazepam (Compound) causes Aggression (Side Effect) and Aggression (Side Effect) is caused by Flumazenil (Compound)
Temazepam (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that could ex... |
DB09074 | DB09118 | 1,362 | 1,580 | [
"DDInter1327",
"DDInter1711"
] | Olaparib | Stiripentol | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Major | 2 | [
[
[
1362,
25,
1580
]
],
[
[
1362,
24,
283
],
[
283,
63,
1580
]
],
[
[
1362,
63,
168
],
[
168,
24,
1580
]
],
[
[
1362,
24,
98
],
[
98,
... | [
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stiripentol"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomi... |
DB00723 | DB01064 | 1,240 | 1,148 | [
"DDInter1176",
"DDInter987"
] | Methoxamine | Isoprenaline | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1240,
24,
1148
]
],
[
[
1240,
24,
480
],
[
480,
24,
1148
]
],
[
[
1240,
1,
584
],
[
584,
63,
1148
]
],
[
[
1240,
24,
959
],
[
959,
... | [
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Methoxamine (Compound) resembles Levonordefrin (Compound) and Levonordefrin may cause a moderate interaction ... |
DB00390 | DB00424 | 1,252 | 19 | [
"DDInter554",
"DDInter896"
] | Digoxin | Hyoscyamine | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Minor | 0 | [
[
[
1252,
23,
19
]
],
[
[
1252,
25,
1166
],
[
1166,
1,
19
]
],
[
[
1252,
23,
85
],
[
85,
63,
19
]
],
[
[
1252,
18,
4930
],
[
4930,
5... | [
[
[
"Digoxin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyoscyamine"
]
],
[
[
"Digoxin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
],
[
"Dolasetron",
... | Digoxin may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (Compound) resembles Hyoscyamine (Compound)
Digoxin may cause a minor interaction that can limit clinical effects when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when ... |
DB00694 | DB08871 | 51 | 36 | [
"DDInter485",
"DDInter666"
] | Daunorubicin | Eribulin | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
51,
24,
36
]
],
[
[
51,
63,
122
],
[
122,
23,
36
]
],
[
[
51,
23,
1247
],
[
1247,
23,
36
]
],
[
[
51,
24,
519
],
[
519,
24,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verapamil"
],
[
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulf... |
DB01142 | DB01211 | 1,264 | 609 | [
"DDInter593",
"DDInter393"
] | Doxepin | Clarithromycin | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1264,
24,
609
]
],
[
[
1264,
63,
1570
],
[
1570,
24,
609
]
],
[
[
1264,
6,
4973
],
[
4973,
45,
609
]
],
[
[
1264,
21,
28759
],
[
28759... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Doxepin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Doxepin (Compo... |
DB09322 | DB16627 | 1,114 | 1,125 | [
"DDInter1966",
"DDInter1145"
] | Zinc sulfate | Melphalan flufenamide | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan].[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. _In vitro_ models show that melphalan is 10 to hundreds of times more potent than melphala... | Minor | 0 | [
[
[
1114,
23,
1125
]
],
[
[
1114,
62,
1096
],
[
1096,
23,
1193
],
[
1193,
23,
1125
]
],
[
[
1114,
23,
725
],
[
725,
62,
1193
],
[
1193,
... | [
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Melphalan flufenamide"
]
],
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mycophenolic aci... | Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with... |
DB00224 | DB05239 | 215 | 866 | [
"DDInter917",
"DDInter425"
] | Indinavir | Cobimetinib | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
215,
25,
866
]
],
[
[
215,
25,
214
],
[
214,
63,
866
]
],
[
[
215,
24,
1051
],
[
1051,
24,
866
]
],
[
[
215,
24,
98
],
[
98,
63,... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
],
[
"Fostamatinib",
"{u... | Indinavir may lead to a major life threatening interaction when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutet... |
DB00682 | DB00976 | 126 | 1,056 | [
"DDInter1951",
"DDInter1758"
] | Warfarin | Telithromycin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
126,
24,
1056
]
],
[
[
126,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
126,
6,
7950
],
[
7950,
45,
1056
]
],
[
[
126,
25,
112
],
[
112,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Warfarin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Telithromycin (Compound)
Warfarin may lead to a major life threatening interaction wh... |
DB00026 | DB01254 | 1,184 | 1,213 | [
"DDInter94",
"DDInter484"
] | Anakinra | Dasatinib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1184,
24,
1213
]
],
[
[
1184,
24,
1136
],
[
1136,
63,
1213
]
],
[
[
1184,
24,
1555
],
[
1555,
24,
1213
]
],
[
[
1184,
25,
962
],
[
962... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
],
[
"D... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Denosumab and Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin ... |
DB00816 | DB00818 | 1,674 | 898 | [
"DDInter1346",
"DDInter1538"
] | Orciprenaline | Propofol | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
1674,
24,
898
]
],
[
[
1674,
21,
28841
],
[
28841,
60,
898
]
],
[
[
1674,
63,
746
],
[
746,
23,
898
]
],
[
[
1674,
24,
392
],
[
392,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Orciprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Bronchospasm"
],
[
"Bronchospasm",
"{u} (Side Effec... | Orciprenaline (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Propofol (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Dyphylline and Dyphylline may cause a minor interaction that can limit clinical effects when taken with... |
DB00912 | DB15982 | 473 | 1,339 | [
"DDInter1581",
"DDInter193"
] | Repaglinide | Berotralstat | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
473,
24,
1339
]
],
[
[
473,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
473,
24,
222
],
[
222,
23,
1339
]
],
[
[
473,
24,
761
],
[
761,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sib... |
DB00734 | DB01176 | 1,664 | 537 | [
"DDInter1605",
"DDInter453"
] | Risperidone | Cyclizine | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1664,
24,
537
]
],
[
[
1664,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1664,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1664,
24,
104
],
[
104,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cet... |
DB00850 | DB06704 | 1,630 | 247 | [
"DDInter1432",
"DDInter951"
] | Perphenazine | Iobenguane (I-123) | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
1630,
24,
247
]
],
[
[
1630,
7,
6952
],
[
6952,
46,
247
]
],
[
[
1630,
18,
7359
],
[
7359,
57,
247
]
],
[
[
1630,
21,
28921
],
[
28921... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Perphenazine",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
"{u} (Gene) is upregulated by ... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Perphenazine (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Iobenguane (Compound)
Perphenazine (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Iobenguane (Compou... |
DB09498 | DB15762 | 810 | 725 | [
"DDInter1715",
"DDInter1644"
] | Strontium chloride Sr-89 | Satralizumab | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Moderate | 1 | [
[
[
810,
24,
725
]
],
[
[
810,
63,
1362
],
[
1362,
24,
725
]
],
[
[
810,
24,
738
],
[
738,
24,
725
]
],
[
[
810,
24,
676
],
[
676,
2... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab
Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00582 | DB08871 | 1,622 | 36 | [
"DDInter1946",
"DDInter666"
] | Voriconazole | Eribulin | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1622,
24,
36
]
],
[
[
1622,
24,
973
],
[
973,
24,
36
]
],
[
[
1622,
63,
1424
],
[
1424,
24,
36
]
],
[
[
1622,
74,
600
],
[
600,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine... |
DB00281 | DB08881 | 608 | 868 | [
"DDInter1066",
"DDInter1925"
] | Lidocaine | Vemurafenib | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Minor | 0 | [
[
[
608,
23,
868
]
],
[
[
608,
6,
8374
],
[
8374,
45,
868
]
],
[
[
608,
18,
15501
],
[
15501,
57,
868
]
],
[
[
608,
21,
28847
],
[
28847,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vemurafenib"
]
],
[
[
"Lidocaine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Lidocaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Lidocaine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Vemurafenib (Compound)
Lidocaine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Vemurafenib (Comp... |
DB00694 | DB06595 | 51 | 1,491 | [
"DDInter485",
"DDInter1214"
] | Daunorubicin | Midostaurin | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
51,
24,
1491
]
],
[
[
51,
23,
112
],
[
112,
23,
1491
]
],
[
[
51,
63,
888
],
[
888,
24,
1491
]
],
[
[
51,
24,
270
],
[
270,
63,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and ... |
DB00396 | DB12500 | 989 | 283 | [
"DDInter1529",
"DDInter714"
] | Progesterone | Fedratinib | Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss. Progesterone is used in var... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
989,
24,
283
]
],
[
[
989,
24,
1419
],
[
1419,
24,
283
]
],
[
[
989,
63,
600
],
[
600,
24,
283
]
],
[
[
989,
1,
891
],
[
891,
24... | [
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluco... |
DB06595 | DB08826 | 1,491 | 1,292 | [
"DDInter1214",
"DDInter489"
] | Midostaurin | Deferiprone | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1491,
25,
1292
]
],
[
[
1491,
24,
1017
],
[
1017,
63,
1292
]
],
[
[
1491,
63,
72
],
[
72,
24,
1292
]
],
[
[
1491,
63,
1101
],
[
1101,
... | [
[
[
"Midostaurin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
"Lorlati... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and El... |
DB00489 | DB01168 | 17 | 1,053 | [
"DDInter1704",
"DDInter1526"
] | Sotalol | Procarbazine | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
17,
24,
1053
]
],
[
[
17,
1,
1248
],
[
1248,
40,
1053
]
],
[
[
17,
35,
848
],
[
848,
40,
1053
]
],
[
[
17,
21,
28762
],
[
28762,
... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Sotalol",
"{u} (Compound) resembles {v} (Compound)",
"Atenolol"
],
[
"Atenolol",
"{u} (Compound) resembles {v} (C... | Sotalol (Compound) resembles Atenolol (Compound) and Atenolol (Compound) resembles Procarbazine (Compound)
Sotalol (Compound) resembles Ibuprofen (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
So... |
DB00969 | DB06717 | 2 | 875 | [
"DDInter52",
"DDInter778"
] | Alosetron | Fosaprepitant | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
2,
24,
875
]
],
[
[
2,
63,
723
],
[
723,
1,
875
]
],
[
[
2,
21,
29180
],
[
29180,
60,
875
]
],
[
[
2,
24,
86
],
[
86,
24,
... | [
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Alosetron (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Fosaprepitant (Compound)
Alosetron may caus... |
DB00545 | DB00959 | 751 | 1,486 | [
"DDInter1548",
"DDInter1191"
] | Pyridostigmine | Methylprednisolone | Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of ... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
751,
24,
1486
]
],
[
[
751,
24,
175
],
[
175,
40,
1486
]
],
[
[
751,
24,
167
],
[
167,
1,
1486
]
],
[
[
751,
63,
251
],
[
251,
1... | [
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolo... | Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) re... |
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