drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00366 | DB00532 | 1,594 | 208 | [
"DDInter600",
"DDInter1152"
] | Doxylamine | Mephenytoin | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
1594,
24,
208
]
],
[
[
1594,
63,
1242
],
[
1242,
24,
208
]
],
[
[
1594,
24,
1219
],
[
1219,
63,
208
]
],
[
[
1594,
24,
530
],
[
530,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Mephenytoin
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatad... |
DB00832 | DB01075 | 499 | 1,376 | [
"DDInter1446",
"DDInter569"
] | Phensuximide | Diphenhydramine | Phensuximide is a member of the succinimide class with anticonvulsant properties. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
499,
24,
1376
]
],
[
[
499,
63,
128
],
[
128,
24,
1376
]
],
[
[
499,
24,
401
],
[
401,
24,
1376
]
],
[
[
499,
6,
10215
],
[
10215,
... | [
[
[
"Phensuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Phensuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine... | Phensuximide may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Phensuximide may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00427 | DB09076 | 1,233 | 1,116 | [
"DDInter1879",
"DDInter1899"
] | Triprolidine | Umeclidinium | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1233,
24,
1116
]
],
[
[
1233,
24,
849
],
[
849,
24,
1116
]
],
[
[
1233,
63,
695
],
[
695,
24,
1116
]
],
[
[
1233,
24,
337
],
[
337,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and C... |
DB01236 | DB11730 | 679 | 351 | [
"DDInter1664",
"DDInter1588"
] | Sevoflurane | Ribociclib | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
679,
25,
351
]
],
[
[
679,
62,
112
],
[
112,
23,
351
]
],
[
[
679,
63,
355
],
[
355,
24,
351
]
],
[
[
679,
24,
1491
],
[
1491,
2... | [
[
[
"Sevoflurane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Sevoflurane",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Sevoflurane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lac... |
DB01044 | DB12141 | 246 | 971 | [
"DDInter809",
"DDInter817"
] | Gatifloxacin | Gilteritinib | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
246,
25,
971
]
],
[
[
246,
62,
112
],
[
112,
23,
971
]
],
[
[
246,
64,
485
],
[
485,
24,
971
]
],
[
[
246,
25,
823
],
[
823,
63,... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Gatifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Gatifloxacin may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine ... |
DB00855 | DB01009 | 213 | 935 | [
"DDInter72",
"DDInter1009"
] | Aminolevulinic acid | Ketoprofen | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Major | 2 | [
[
[
213,
25,
935
]
],
[
[
213,
64,
1274
],
[
1274,
24,
935
]
],
[
[
213,
7,
5998
],
[
5998,
46,
935
]
],
[
[
213,
21,
28701
],
[
28701,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ketoprofen"
]
],
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Flurbiprofen"
],
[
"Flurb... | Aminolevulinic acid may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Aminolevulinic acid (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Ketoprofen (Compound)
A... |
DB00015 | DB14357 | 582 | 944 | [
"DDInter1585",
"DDInter347"
] | Reteplase | Chamomile | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
582,
23,
944
]
],
[
[
582,
25,
256
],
[
256,
23,
944
]
],
[
[
582,
64,
1578
],
[
1578,
23,
944
]
],
[
[
582,
24,
1061
],
[
1061,
... | [
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Reteplase may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Reteplase may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a minor interaction that... |
DB00026 | DB00851 | 1,184 | 611 | [
"DDInter94",
"DDInter463"
] | Anakinra | Dacarbazine | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
1184,
24,
611
]
],
[
[
1184,
24,
141
],
[
141,
24,
611
]
],
[
[
1184,
24,
850
],
[
850,
63,
611
]
],
[
[
1184,
63,
305
],
[
305,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin an... |
DB00630 | DB09146 | 1,485 | 489 | [
"DDInter42",
"DDInter978"
] | Alendronic acid | Iron sucrose | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
1485,
24,
489
]
],
[
[
1485,
1,
1008
],
[
1008,
24,
489
]
],
[
[
1485,
24,
1596
],
[
1596,
24,
489
]
],
[
[
1485,
24,
428
],
[
428,
... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Alendronic acid",
"{u} (Compound) resembles {v} (Compound)",
"Risedronic acid"
],
[
"Risedronic acid",
"{... | Alendronic acid (Compound) resembles Risedronic acid (Compound) and Risedronic acid may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a moderate interaction ... |
DB06699 | DB09080 | 774 | 144 | [
"DDInter493",
"DDInter1331"
] | Degarelix | Olodaterol | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
774,
24,
144
]
],
[
[
774,
62,
1247
],
[
1247,
23,
144
]
],
[
[
774,
63,
956
],
[
956,
24,
144
]
],
[
[
774,
25,
1011
],
[
1011,
... | [
[
[
"Degarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Degarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Degarelix may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Olodaterol
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and... |
DB00692 | DB00726 | 274 | 1,164 | [
"DDInter1448",
"DDInter1876"
] | Phentolamine | Trimipramine | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
274,
24,
1164
]
],
[
[
274,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
274,
63,
508
],
[
508,
40,
1164
]
],
[
[
274,
6,
3895
],
[
3895,
... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Trimipramine (... |
DB01114 | DB06691 | 272 | 849 | [
"DDInter362",
"DDInter1155"
] | Chlorpheniramine | Mepyramine | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
272,
24,
849
]
],
[
[
272,
1,
11775
],
[
11775,
40,
849
]
],
[
[
272,
40,
11244
],
[
11244,
1,
849
]
],
[
[
272,
74,
1594
],
[
1594,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Chlorpheniramine",
"{u} (Compound) resembles {v} (Compound)",
"Chloropyramine"
],
[
"Chloropyramine",
"{u}... | Chlorpheniramine (Compound) resembles Chloropyramine (Compound) and Chloropyramine (Compound) resembles Mepyramine (Compound)
Chlorpheniramine (Compound) resembles Pheniramine (Compound) and Pheniramine (Compound) resembles Mepyramine (Compound)
Chlorpheniramine (Compound) resembles Doxylamine (Compound) and Chlorpheni... |
DB00197 | DB09083 | 1,324 | 880 | [
"DDInter1881",
"DDInter996"
] | Troglitazone | Ivabradine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Moderate | 1 | [
[
[
1324,
24,
880
]
],
[
[
1324,
24,
480
],
[
480,
24,
880
]
],
[
[
1324,
24,
159
],
[
159,
63,
880
]
],
[
[
1324,
23,
1101
],
[
1101,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivabradine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and... |
DB00927 | DB01244 | 1,559 | 762 | [
"DDInter712",
"DDInter192"
] | Famotidine | Bepridil | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
1559,
24,
762
]
],
[
[
1559,
63,
675
],
[
675,
40,
762
]
],
[
[
1559,
21,
28698
],
[
28698,
60,
762
]
],
[
[
1559,
62,
112
],
[
112,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
],
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Bepridil (Compound)
Famotidine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Bepridil (Compound)
Famotidine may cause a minor inter... |
DB00526 | DB01211 | 1,555 | 609 | [
"DDInter1355",
"DDInter393"
] | Oxaliplatin | Clarithromycin | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1555,
24,
609
]
],
[
[
1555,
63,
1570
],
[
1570,
24,
609
]
],
[
[
1555,
6,
7950
],
[
7950,
45,
609
]
],
[
[
1555,
63,
600
],
[
600,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Oxaliplatin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clarithromycin (Compound)
Oxal... |
DB01224 | DB09076 | 623 | 1,116 | [
"DDInter1553",
"DDInter1899"
] | Quetiapine | Umeclidinium | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
623,
24,
1116
]
],
[
[
623,
24,
849
],
[
849,
24,
1116
]
],
[
[
623,
40,
695
],
[
695,
24,
1116
]
],
[
[
623,
63,
401
],
[
401,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Quetiapine (Compound) resembles Clozapine (Compound) and Clozapine may cause a moderate interaction that could... |
DB00445 | DB14444 | 322 | 151 | [
"DDInter655",
"DDInter924"
] | Epirubicin | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
322,
24,
151
]
],
[
[
322,
63,
66
],
[
66,
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]
],
[
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],
[
1619,
24,
151
]
],
[
[
322,
64,
550
],
[
550,
24,... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could e... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Epirubicin may cause a moderate inter... |
DB00444 | DB15093 | 63 | 1,654 | [
"DDInter1765",
"DDInter1698"
] | Teniposide | Somapacitan | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
63,
24,
1654
]
],
[
[
63,
63,
168
],
[
168,
23,
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],
[
[
63,
63,
10
],
[
10,
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]
],
[
[
63,
24,
351
],
[
351,
24,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone ma... |
DB01099 | DB01172 | 1,272 | 416 | [
"DDInter744",
"DDInter1004"
] | Flucytosine | Kanamycin | A fluorinated cytosine analog that is used as an antifungal agent. | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Moderate | 1 | [
[
[
1272,
24,
416
]
],
[
[
1272,
21,
29196
],
[
29196,
60,
416
]
],
[
[
1272,
63,
831
],
[
831,
24,
416
]
],
[
[
1272,
24,
712
],
[
712,
... | [
[
[
"Flucytosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
]
],
[
[
"Flucytosine",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
"{u} (Side Effect) ... | Flucytosine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Kanamycin (Compound)
Flucytosine may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00407 | DB01254 | 202 | 1,213 | [
"DDInter115",
"DDInter484"
] | Ardeparin | Dasatinib | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
202,
25,
1213
]
],
[
[
202,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
202,
24,
738
],
[
738,
63,
1213
]
],
[
[
202,
24,
121
],
[
121,
... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Ardeparin",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature increased",
"{u} (Side... | Ardeparin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate dis... |
DB00468 | DB01080 | 1,424 | 855 | [
"DDInter1557",
"DDInter1933"
] | Quinine | Vigabatrin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Major | 2 | [
[
[
1424,
25,
855
]
],
[
[
1424,
21,
32847
],
[
32847,
60,
855
]
],
[
[
1424,
63,
1010
],
[
1010,
24,
855
]
],
[
[
1424,
24,
401
],
[
401,... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vigabatrin"
]
],
[
[
"Quinine",
"{u} (Compound) causes {v} (Side Effect)",
"Visual field constriction"
],
[
"Visual field constriction",
"{u} (Side Effe... | Quinine (Compound) causes Visual field constriction (Side Effect) and Visual field constriction (Side Effect) is caused by Vigabatrin (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that could exacerbate diseas... |
DB00022 | DB08904 | 268 | 375 | [
"DDInter1408",
"DDInter342"
] | Peginterferon alfa-2b | Certolizumab pegol | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
268,
24,
375
]
],
[
[
268,
24,
231
],
[
231,
24,
375
]
],
[
[
268,
24,
1434
],
[
1434,
63,
375
]
],
[
[
268,
63,
491
],
[
491,
2... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when take... |
DB00848 | DB10989 | 281 | 496 | [
"DDInter1044",
"DDInter858"
] | Levamisole | Hepatitis A Vaccine | Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this,... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
281,
24,
496
]
],
[
[
281,
24,
4
],
[
4,
24,
496
]
],
[
[
281,
24,
738
],
[
738,
63,
496
]
],
[
[
281,
25,
976
],
[
976,
24,
... | [
[
[
"Levamisole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Levamisole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesu... | Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Levamisole may cause a moderate interaction that could exacerbate disease... |
DB00480 | DB06674 | 1,668 | 908 | [
"DDInter1035",
"DDInter837"
] | Lenalidomide | Golimumab | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
1668,
25,
908
]
],
[
[
1668,
24,
200
],
[
200,
63,
908
]
],
[
[
1668,
64,
1463
],
[
1463,
24,
908
]
],
[
[
1668,
24,
1136
],
[
1136,
... | [
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
[
"C... | Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Lenalidomide may lead to a major life threatening interaction when taken with Lovastatin and Lovast... |
DB00850 | DB13928 | 1,630 | 1,385 | [
"DDInter1432",
"DDInter1660"
] | Perphenazine | Semaglutide | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
1630,
24,
1385
]
],
[
[
1630,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
1630,
63,
73
],
[
73,
24,
1385
]
],
[
[
1630,
24,
1148
],
[
1148,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
"Pasi... | Perphenazine may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine m... |
DB00685 | DB00712 | 1,299 | 1,274 | [
"DDInter1887",
"DDInter763"
] | Trovafloxacin | Flurbiprofen | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
1299,
24,
1274
]
],
[
[
1299,
21,
28769
],
[
28769,
60,
1274
]
],
[
[
1299,
24,
1613
],
[
1613,
63,
1274
]
],
[
[
1299,
25,
1411
],
[
... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
"{u}... | Trovafloxacin (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could... |
DB00095 | DB12332 | 66 | 1,619 | [
"DDInter623",
"DDInter1626"
] | Efalizumab | Rucaparib | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
66,
24,
1619
]
],
[
[
66,
24,
259
],
[
259,
24,
1619
]
],
[
[
66,
24,
151
],
[
151,
63,
1619
]
],
[
[
66,
63,
58
],
[
58,
24,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/Ca... |
DB05679 | DB06317 | 1,683 | 1,626 | [
"DDInter1907",
"DDInter630"
] | Ustekinumab | Elotuzumab | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
1683,
24,
1626
]
],
[
[
1683,
63,
973
],
[
973,
24,
1626
]
],
[
[
1683,
24,
200
],
[
200,
63,
1626
]
],
[
[
1683,
24,
1531
],
[
1531,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans an... |
DB00927 | DB06595 | 1,559 | 1,491 | [
"DDInter712",
"DDInter1214"
] | Famotidine | Midostaurin | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1559,
24,
1491
]
],
[
[
1559,
62,
112
],
[
112,
23,
1491
]
],
[
[
1559,
23,
1247
],
[
1247,
23,
1491
]
],
[
[
1559,
63,
888
],
[
888,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Famotidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and... |
DB00247 | DB00397 | 1,131 | 1,466 | [
"DDInter1194",
"DDInter1458"
] | Methysergide | Phenylpropanolamine | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Major | 2 | [
[
[
1131,
25,
1466
]
],
[
[
1131,
21,
29027
],
[
29027,
60,
1466
]
],
[
[
1131,
25,
1636
],
[
1636,
24,
1466
]
],
[
[
1131,
25,
874
],
[
8... | [
[
[
"Methysergide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylpropanolamine"
]
],
[
[
"Methysergide",
"{u} (Compound) causes {v} (Side Effect)",
"Ataxia"
],
[
"Ataxia",
"{u} (Side Effect) is caused by {v... | Methysergide (Compound) causes Ataxia (Side Effect) and Ataxia (Side Effect) is caused by Phenylpropanolamine (Compound)
Methysergide may lead to a major life threatening interaction when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Phenylpro... |
DB01610 | DB06674 | 248 | 908 | [
"DDInter1912",
"DDInter837"
] | Valganciclovir | Golimumab | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
248,
25,
908
]
],
[
[
248,
63,
268
],
[
268,
24,
908
]
],
[
[
248,
63,
450
],
[
450,
25,
908
]
],
[
[
248,
24,
76
],
[
76,
64,
... | [
[
[
"Valganciclovir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
],
[... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Valganciclovir may cause a moderate interaction that could exacerbate diseases when tak... |
DB00004 | DB10343 | 669 | 962 | [
"DDInter499",
"DDInter160"
] | Denileukin diftitox | Bacillus calmette-guerin substrain tice live antigen | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
669,
25,
962
]
],
[
[
669,
25,
1057
],
[
1057,
25,
962
]
],
[
[
669,
24,
270
],
[
270,
64,
962
]
],
[
[
669,
24,
1362
],
[
1362,
... | [
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Denileukin diftitox may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when ta... |
DB00543 | DB05381 | 87 | 172 | [
"DDInter82",
"DDInter863"
] | Amoxapine | Histamine | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Moderate | 1 | [
[
[
87,
24,
172
]
],
[
[
87,
24,
1264
],
[
1264,
24,
172
]
],
[
[
87,
63,
1242
],
[
1242,
24,
172
]
],
[
[
87,
24,
849
],
[
849,
63,... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histamine"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
"D... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Histamine
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may ... |
DB00618 | DB01253 | 1,572 | 628 | [
"DDInter498",
"DDInter664"
] | Demeclocycline | Ergometrine | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Moderate | 1 | [
[
[
1572,
24,
628
]
],
[
[
1572,
63,
1131
],
[
1131,
40,
628
]
],
[
[
1572,
24,
826
],
[
826,
40,
628
]
],
[
[
1572,
40,
964
],
[
964,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergometrine"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methysergide"
... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Methysergide and Methysergide (Compound) resembles Ergometrine (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Ergometri... |
DB01206 | DB10343 | 37 | 962 | [
"DDInter1086",
"DDInter160"
] | Lomustine | Bacillus calmette-guerin substrain tice live antigen | An alkylating agent of value against both hematologic malignancies and solid tumors. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
37,
25,
962
]
],
[
[
37,
64,
1057
],
[
1057,
25,
962
]
],
[
[
37,
24,
270
],
[
270,
64,
962
]
],
[
[
37,
63,
663
],
[
663,
25,
... | [
[
[
"Lomustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Lomustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
]... | Lomustine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab... |
DB00459 | DB00460 | 640 | 612 | [
"DDInter21",
"DDInter1929"
] | Acitretin | Verteporfin | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Moderate | 1 | [
[
[
640,
24,
612
]
],
[
[
640,
21,
29783
],
[
29783,
60,
612
]
],
[
[
640,
24,
959
],
[
959,
63,
612
]
],
[
[
640,
25,
663
],
[
663,
... | [
[
[
"Acitretin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
]
],
[
[
"Acitretin",
"{u} (Compound) causes {v} (Side Effect)",
"Visual acuity reduced"
],
[
"Visual acuity reduced",
"{u... | Acitretin (Compound) causes Visual acuity reduced (Side Effect) and Visual acuity reduced (Side Effect) is caused by Verteporfin (Compound)
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases wh... |
DB00365 | DB09054 | 839 | 384 | [
"DDInter842",
"DDInter905"
] | Grepafloxacin | Idelalisib | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
839,
24,
384
]
],
[
[
839,
23,
222
],
[
222,
23,
384
]
],
[
[
839,
25,
1618
],
[
1618,
24,
384
]
],
[
[
839,
23,
328
],
[
328,
2... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Grepafloxacin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib ma... |
DB00414 | DB01142 | 590 | 1,264 | [
"DDInter16",
"DDInter593"
] | Acetohexamide | Doxepin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
590,
24,
1264
]
],
[
[
590,
24,
401
],
[
401,
24,
1264
]
],
[
[
590,
24,
463
],
[
463,
23,
1264
]
],
[
[
590,
24,
857
],
[
857,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and... |
DB01124 | DB01284 | 1,411 | 1,042 | [
"DDInter1828",
"DDInter1782"
] | Tolbutamide | Tetracosactide | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1411,
24,
1042
]
],
[
[
1411,
63,
455
],
[
455,
23,
1042
]
],
[
[
1411,
24,
659
],
[
659,
62,
1042
]
],
[
[
1411,
63,
461
],
[
461,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vi... |
DB00564 | DB01619 | 1,236 | 830 | [
"DDInter293",
"DDInter1441"
] | Carbamazepine | Phenindamine | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1236,
24,
830
]
],
[
[
1236,
24,
537
],
[
537,
40,
830
]
],
[
[
1236,
40,
11299
],
[
11299,
1,
830
]
],
[
[
1236,
1,
1335
],
[
1335,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Carbamazepine (Compound) resembles Epinastine (Compound) and Epinastine (Compound) resembles Phenindamine (Compound)
Carbamazepine (Compound) resembles Oxcar... |
DB01041 | DB01192 | 770 | 560 | [
"DDInter1789",
"DDInter1372"
] | Thalidomide | Oxymorphone | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
770,
24,
560
]
],
[
[
770,
63,
828
],
[
828,
1,
560
]
],
[
[
770,
21,
28695
],
[
28695,
60,
560
]
],
[
[
770,
63,
104
],
[
104,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Thalidomide (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Oxymorphone (Compound)
Thalidomide may cause a moderate interaction... |
DB00405 | DB08883 | 128 | 1,597 | [
"DDInter517",
"DDInter1428"
] | Dexbrompheniramine | Perampanel | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
128,
24,
1597
]
],
[
[
128,
24,
100
],
[
100,
24,
1597
]
],
[
[
128,
63,
475
],
[
475,
24,
1597
]
],
[
[
128,
74,
1594
],
[
1594,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromphenira... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Perampanel
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00738 | DB00757 | 485 | 1,166 | [
"DDInter1420",
"DDInter581"
] | Pentamidine | Dolasetron | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
485,
25,
1166
]
],
[
[
485,
6,
12523
],
[
12523,
45,
1166
]
],
[
[
485,
21,
28803
],
[
28803,
60,
1166
]
],
[
[
485,
23,
1247
],
[
124... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Dolas... | Pentamidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dolasetron (Compound)
Pentamidine (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Dolasetron (Compound)
Pentamidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and S... |
DB00264 | DB11348 | 88 | 1,065 | [
"DDInter1200",
"DDInter279"
] | Metoprolol | Calcium Phosphate | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
88,
24,
1065
]
],
[
[
88,
1,
819
],
[
819,
24,
1065
]
],
[
[
88,
40,
1121
],
[
1121,
24,
1065
]
],
[
[
88,
23,
1152
],
[
1152,
2... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Metoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Acebutolol"
],
[
"Acebutolol",
"{u} may cause a ... | Metoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Metoprolol (Compound) resembles Bisoprolol (Compound) and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Calc... |
DB00612 | DB00747 | 1,121 | 1,442 | [
"DDInter216",
"DDInter1647"
] | Bisoprolol | Scopolamine | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
1121,
24,
1442
]
],
[
[
1121,
63,
19
],
[
19,
24,
1442
]
],
[
[
1121,
21,
28766
],
[
28766,
60,
1442
]
],
[
[
1121,
24,
1264
],
[
1264... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Bisoprolol (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Scopolamine... |
DB01001 | DB01218 | 688 | 1,493 | [
"DDInter1632",
"DDInter852"
] | Salbutamol | Halofantrine | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Moderate | 1 | [
[
[
688,
24,
1493
]
],
[
[
688,
6,
8374
],
[
8374,
45,
1493
]
],
[
[
688,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
688,
63,
479
],
[
479,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halofantrine"
]
],
[
[
"Salbutamol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halofantrine (Compound)
Salbutamol (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when ta... |
DB09038 | DB11979 | 1,450 | 1,320 | [
"DDInter636",
"DDInter625"
] | Empagliflozin | Elagolix | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1450,
24,
1320
]
],
[
[
1450,
63,
168
],
[
168,
23,
1320
]
],
[
[
1450,
24,
1612
],
[
1612,
23,
1320
]
],
[
[
1450,
63,
129
],
[
129,
... | [
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fos... |
DB00620 | DB00731 | 175 | 1,144 | [
"DDInter1855",
"DDInter1269"
] | Triamcinolone | Nateglinide | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
175,
24,
1144
]
],
[
[
175,
63,
610
],
[
610,
24,
1144
]
],
[
[
175,
7,
4789
],
[
4789,
45,
1144
]
],
[
[
175,
6,
8374
],
[
8374,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Triamcinolone (Compound) upregulates PPARG (Gene) and PPARG (Gene) is bound by Nateglinide (Compound)
Triamcin... |
DB00468 | DB00916 | 1,424 | 112 | [
"DDInter1557",
"DDInter1202"
] | Quinine | Metronidazole | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
1424,
23,
112
]
],
[
[
1424,
6,
3486
],
[
3486,
45,
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[
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[
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],
[
[
1424,
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],
[
847,
... | [
[
[
"Quinine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Quinine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Quinine (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Metronidazole (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetin... |
DB00970 | DB12674 | 0 | 975 | [
"DDInter466",
"DDInter1105"
] | Dactinomycin | Lurbinectedin | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
0,
24,
975
]
],
[
[
0,
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[
1532,
24,
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[
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[
147,
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[
[
0,
25,
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],
[
1259,
25,
... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine an... |
DB00834 | DB09080 | 932 | 144 | [
"DDInter1215",
"DDInter1331"
] | Mifepristone | Olodaterol | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
932,
24,
144
]
],
[
[
932,
25,
1011
],
[
1011,
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[
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11
],
[
11,
24,
144
]
],
[
[
932,
24,
543
],
[
543,
24,... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingol... | Mifepristone may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Mifepristone may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a moderate ... |
DB00196 | DB00631 | 600 | 372 | [
"DDInter743",
"DDInter405"
] | Fluconazole | Clofarabine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
600,
24,
372
]
],
[
[
600,
24,
1585
],
[
1585,
40,
372
]
],
[
[
600,
21,
28903
],
[
28903,
60,
372
]
],
[
[
600,
25,
945
],
[
945,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Adenosine"
],
[
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Adenosine and Adenosine (Compound) resembles Clofarabine (Compound)
Fluconazole (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Clofarabine (Compound)
Fluconazole may lead to a major life threate... |
DB06228 | DB13874 | 792 | 1,501 | [
"DDInter1609",
"DDInter639"
] | Rivaroxaban | Enasidenib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible ... | Moderate | 1 | [
[
[
792,
24,
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[
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792,
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],
[
1619,
24,
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],
[
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792,
63,
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],
[
1419,
24,
1501
]
],
[
[
792,
25,
1604
],
[
1604,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enasidenib"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib... |
DB00889 | DB11796 | 1,133 | 1,612 | [
"DDInter840",
"DDInter786"
] | Granisetron | Fostemsavir | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
1133,
24,
1612
]
],
[
[
1133,
24,
98
],
[
98,
23,
1612
]
],
[
[
1133,
63,
1324
],
[
1324,
23,
1612
]
],
[
[
1133,
24,
1476
],
[
1476,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
[
... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglit... |
DB00471 | DB08820 | 201 | 1,478 | [
"DDInter1242",
"DDInter997"
] | Montelukast | Ivacaftor | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
201,
24,
1478
]
],
[
[
201,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
201,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
201,
24,
1040
],
[
1040,... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Montelukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Montelukast (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and... |
DB00072 | DB11793 | 550 | 738 | [
"DDInter1846",
"DDInter1297"
] | Trastuzumab | Niraparib | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
550,
24,
738
]
],
[
[
550,
63,
1253
],
[
1253,
24,
738
]
],
[
[
550,
24,
496
],
[
496,
24,
738
]
],
[
[
550,
25,
770
],
[
770,
2... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palifermin"
],
[
... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine ... |
DB01155 | DB01362 | 872 | 497 | [
"DDInter813",
"DDInter960"
] | Gemifloxacin | Iohexol | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
872,
25,
497
]
],
[
[
872,
21,
28787
],
[
28787,
60,
497
]
],
[
[
872,
64,
891
],
[
891,
25,
497
]
],
[
[
872,
63,
1264
],
[
1264,
... | [
[
[
"Gemifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused by {v} (C... | Gemifloxacin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iohexol (Compound)
Gemifloxacin may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may lead to a major life threatening interaction when taken with Iohexol
Gemifloxacin may cause... |
DB01059 | DB01206 | 956 | 37 | [
"DDInter1313",
"DDInter1086"
] | Norfloxacin | Lomustine | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Minor | 0 | [
[
[
956,
23,
37
]
],
[
[
956,
6,
8374
],
[
8374,
45,
37
]
],
[
[
956,
21,
28675
],
[
28675,
60,
37
]
],
[
[
956,
40,
1176
],
[
1176,
... | [
[
[
"Norfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomustine"
]
],
[
[
"Norfloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomustine (Compound)
Norfloxacin (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Lomustine (Compound)
Norfloxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a minor in... |
DB00078 | DB01097 | 1,172 | 1,377 | [
"DDInter898",
"DDInter1033"
] | Ibritumomab tiuxetan | Leflunomide | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1172,
25,
1377
]
],
[
[
1172,
24,
949
],
[
949,
63,
1377
]
],
[
[
1172,
25,
126
],
[
126,
24,
1377
]
],
[
[
1172,
24,
563
],
[
563,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani to... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
I... |
DB06643 | DB08901 | 1,136 | 1,468 | [
"DDInter500",
"DDInter1492"
] | Denosumab | Ponatinib | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1136,
24,
1468
]
],
[
[
1136,
63,
478
],
[
478,
24,
1468
]
],
[
[
1136,
24,
384
],
[
384,
63,
1468
]
],
[
[
1136,
24,
850
],
[
850,
... | [
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib ... |
DB08865 | DB09330 | 1,593 | 985 | [
"DDInter448",
"DDInter1352"
] | Crizotinib | Osimertinib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1593,
25,
985
]
],
[
[
1593,
62,
1247
],
[
1247,
23,
985
]
],
[
[
1593,
63,
112
],
[
112,
23,
985
]
],
[
[
1593,
64,
1478
],
[
1478,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Crizotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfa... | Crizotinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazol... |
DB11689 | DB14723 | 321 | 159 | [
"DDInter1659",
"DDInter1026"
] | Selumetinib | Larotrectinib | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
321,
24,
159
]
],
[
[
321,
63,
98
],
[
98,
24,
159
]
],
[
[
321,
64,
597
],
[
597,
24,
159
]
],
[
[
321,
24,
1619
],
[
1619,
24,... | [
[
[
"Selumetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Selumetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
[... | Selumetinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Selumetinib may lead to a major life threatening interaction when taken with Chloramphenicol and Chloramphenicol... |
DB00215 | DB11186 | 1,230 | 1,609 | [
"DDInter388",
"DDInter1427"
] | Citalopram | Pentoxyverine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1230,
24,
1609
]
],
[
[
1230,
24,
104
],
[
104,
24,
1609
]
],
[
[
1230,
25,
506
],
[
506,
24,
1609
]
],
[
[
1230,
1,
318
],
[
318,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Citalopram may lead to a major life threatening interaction when taken with Dextromethorphan and Dextrome... |
DB00916 | DB09078 | 112 | 1,228 | [
"DDInter1202",
"DDInter1036"
] | Metronidazole | Lenvatinib | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Minor | 0 | [
[
[
112,
23,
1228
]
],
[
[
112,
24,
463
],
[
463,
23,
1228
]
],
[
[
112,
23,
1247
],
[
1247,
23,
1228
]
],
[
[
112,
62,
1100
],
[
1100,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lenvatinib"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],
... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole an... |
DB00322 | DB05273 | 141 | 507 | [
"DDInter742",
"DDInter1638"
] | Floxuridine | Samarium (153Sm) lexidronam | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
141,
25,
507
]
],
[
[
141,
24,
248
],
[
248,
24,
507
]
],
[
[
141,
24,
270
],
[
270,
63,
507
]
],
[
[
141,
1,
1083
],
[
1083,
25... | [
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Floxuridine may cause a moderate interaction that could exacerbate diseases when taken... |
DB11113 | DB11921 | 657 | 1,019 | [
"DDInter307",
"DDInter492"
] | Castor oil | Deflazacort | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of, which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic,... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
657,
24,
1019
]
],
[
[
657,
63,
443
],
[
443,
24,
1019
]
],
[
[
657,
24,
1375
],
[
1375,
63,
1019
]
],
[
[
657,
24,
938
],
[
938,
... | [
[
[
"Castor oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Castor oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
],
... | Castor oil may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Castor oil may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin an... |
DB06717 | DB09143 | 875 | 313 | [
"DDInter778",
"DDInter1701"
] | Fosaprepitant | Sonidegib | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Major | 2 | [
[
[
875,
25,
313
]
],
[
[
875,
63,
379
],
[
379,
23,
313
]
],
[
[
875,
63,
478
],
[
478,
24,
313
]
],
[
[
875,
25,
1478
],
[
1478,
2... | [
[
[
"Fosaprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sonidegib"
]
],
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
[
"Rabe... | Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Ni... |
DB05015 | DB09498 | 1,077 | 810 | [
"DDInter174",
"DDInter1715"
] | Belinostat | Strontium chloride Sr-89 | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1077,
24,
810
]
],
[
[
1077,
63,
597
],
[
597,
24,
810
]
],
[
[
1077,
24,
1619
],
[
1619,
63,
810
]
],
[
[
1077,
24,
1362
],
[
1362,
... | [
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenic... | Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Belinostat may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00104 | DB12141 | 966 | 971 | [
"DDInter1323",
"DDInter817"
] | Octreotide | Gilteritinib | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
966,
24,
971
]
],
[
[
966,
23,
466
],
[
466,
62,
971
]
],
[
[
966,
24,
1645
],
[
1645,
24,
971
]
],
[
[
966,
24,
69
],
[
69,
63,... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Octreotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Octreotide may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metfo... |
DB01059 | DB01177 | 956 | 77 | [
"DDInter1313",
"DDInter904"
] | Norfloxacin | Idarubicin | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
956,
24,
77
]
],
[
[
956,
21,
28987
],
[
28987,
60,
77
]
],
[
[
956,
40,
1467
],
[
1467,
23,
77
]
],
[
[
956,
62,
112
],
[
112,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Norfloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Chills"
],
[
"Chills",
"{u} (Side Effect) is caused b... | Norfloxacin (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Idarubicin (Compound)
Norfloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin may cause a minor interaction that can limit clinical effects when taken with Idarubicin
Norfloxacin may cause a minor interaction that can lim... |
DB00959 | DB12500 | 1,486 | 283 | [
"DDInter1191",
"DDInter714"
] | Methylprednisolone | Fedratinib | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1486,
24,
283
]
],
[
[
1486,
24,
351
],
[
351,
23,
283
]
],
[
[
1486,
63,
122
],
[
122,
23,
283
]
],
[
[
1486,
24,
1339
],
[
1339,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Verapam... |
DB01124 | DB01185 | 1,411 | 155 | [
"DDInter1828",
"DDInter759"
] | Tolbutamide | Fluoxymesterone | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Moderate | 1 | [
[
[
1411,
24,
155
]
],
[
[
1411,
24,
1546
],
[
1546,
40,
155
]
],
[
[
1411,
63,
1561
],
[
1561,
40,
155
]
],
[
[
1411,
63,
175
],
[
175,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Fluoxymesterone (Compound)
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) resem... |
DB00307 | DB00661 | 1,101 | 122 | [
"DDInter202",
"DDInter1928"
] | Bexarotene | Verapamil | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Minor | 0 | [
[
[
1101,
23,
122
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
122
]
],
[
[
1101,
21,
28809
],
[
28809,
60,
122
]
],
[
[
1101,
24,
466
],
[
466,
... | [
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Verapamil"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Verapamil (Compound)
Bexarotene (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Verapamil (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Daro... |
DB01612 | DB06237 | 1,637 | 438 | [
"DDInter92",
"DDInter141"
] | Amyl Nitrite | Avanafil | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual ... | Major | 2 | [
[
[
1637,
25,
438
]
],
[
[
1637,
24,
549
],
[
549,
63,
438
]
],
[
[
1637,
25,
1455
],
[
1455,
63,
438
]
],
[
[
1637,
63,
885
],
[
885,
... | [
[
[
"Amyl Nitrite",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avanafil"
]
],
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
[
"Dapag... | Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Avanafil
Amyl Nitrite may lead to a major life threatening interaction when taken with Nitrous acid and Nitrous aci... |
DB00978 | DB01276 | 739 | 123 | [
"DDInter1084",
"DDInter706"
] | Lomefloxacin | Exenatide | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
739,
24,
123
]
],
[
[
739,
64,
1573
],
[
1573,
24,
123
]
],
[
[
739,
1,
1539
],
[
1539,
24,
123
]
],
[
[
739,
25,
1154
],
[
1154,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Lomefloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
],
[
"Prednis... | Lomefloxacin may lead to a major life threatening interaction when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Lomefloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that could exacerbate di... |
DB01166 | DB09237 | 477 | 1,586 | [
"DDInter379",
"DDInter1045"
] | Cilostazol | Levamlodipine | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
477,
24,
1586
]
],
[
[
477,
24,
578
],
[
578,
23,
1586
]
],
[
[
477,
24,
478
],
[
478,
24,
1586
]
],
[
[
477,
24,
1297
],
[
1297,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Niloti... |
DB01364 | DB09100 | 22 | 320 | [
"DDInter650",
"DDInter1799"
] | Ephedrine | Thyroid, porcine | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
22,
24,
320
]
],
[
[
22,
63,
127
],
[
127,
24,
320
]
],
[
[
22,
24,
135
],
[
135,
24,
320
]
],
[
[
22,
74,
73
],
[
73,
24,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
],
[
... | Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Thyroid, porcine
Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide and Albig... |
DB06228 | DB14006 | 792 | 972 | [
"DDInter1609",
"DDInter370"
] | Rivaroxaban | Choline salicylate | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
792,
24,
972
]
],
[
[
792,
64,
553
],
[
553,
24,
972
]
],
[
[
792,
63,
1039
],
[
1039,
24,
972
]
],
[
[
792,
24,
1074
],
[
1074,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
],
[
... | Rivaroxaban may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and De... |
DB00059 | DB00284 | 1,560 | 1,647 | [
"DDInter1404",
"DDInter11"
] | Pegaspargase | Acarbose | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Moderate | 1 | [
[
[
1560,
24,
1647
]
],
[
[
1560,
24,
279
],
[
279,
62,
1647
]
],
[
[
1560,
24,
1072
],
[
1072,
63,
1647
]
],
[
[
1560,
24,
1176
],
[
1176... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a minor interaction that can limit clinical effects when taken with Acarbose
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoni... |
DB00450 | DB09098 | 78 | 98 | [
"DDInter603",
"DDInter1700"
] | Droperidol | Somatrem | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
78,
24,
98
]
],
[
[
78,
24,
159
],
[
159,
63,
98
]
],
[
[
78,
25,
11
],
[
11,
24,
98
]
],
[
[
78,
1,
1300
],
[
1300,
24,
9... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Droperidol may lead to a major life threatening interaction when taken with Toremifene and Toremifene may ca... |
DB00372 | DB00427 | 999 | 1,233 | [
"DDInter1793",
"DDInter1879"
] | Thiethylperazine | Triprolidine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
999,
24,
1233
]
],
[
[
999,
24,
686
],
[
686,
63,
1233
]
],
[
[
999,
24,
536
],
[
536,
24,
1233
]
],
[
[
999,
63,
1023
],
[
1023,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Oxazepam and Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Secobarbita... |
DB00073 | DB09074 | 1,394 | 1,362 | [
"DDInter1608",
"DDInter1327"
] | Rituximab | Olaparib | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1394,
24,
1362
]
],
[
[
1394,
25,
725
],
[
725,
63,
1362
]
],
[
[
1394,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
1394,
24,
987
],
[
987,
... | [
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
],
[
"Satralizumab... | Rituximab may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may caus... |
DB00205 | DB09104 | 929 | 286 | [
"DDInter1550",
"DDInter1118"
] | Pyrimethamine | Magnesium hydroxide | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
929,
24,
286
]
],
[
[
929,
24,
1243
],
[
1243,
24,
286
]
],
[
[
929,
25,
1292
],
[
1292,
24,
286
]
],
[
[
929,
24,
1243
],
[
1243,
... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Proguanil"
... | Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Proguanil and Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide
Pyrimethamine may lead to a major life threatening interaction when taken with Deferiprone and Deferip... |
DB00222 | DB00359 | 245 | 161 | [
"DDInter825",
"DDInter1721"
] | Glimepiride | Sulfadiazine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. | Moderate | 1 | [
[
[
245,
24,
161
]
],
[
[
245,
24,
1029
],
[
1029,
40,
161
]
],
[
[
245,
6,
6017
],
[
6017,
45,
161
]
],
[
[
245,
21,
29232
],
[
29232,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfisoxazole"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfadiazine (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sulfadiazine (Compound)
Glimepiride (Compound) causes Urticaria (Side Effect) ... |
DB03619 | DB06754 | 557 | 707 | [
"DDInter501",
"DDInter471"
] | Deoxycholic acid | Danaparoid | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Moderate | 1 | [
[
[
557,
24,
707
]
],
[
[
557,
24,
1496
],
[
1496,
63,
707
]
],
[
[
557,
24,
235
],
[
235,
64,
707
]
],
[
[
557,
63,
1172
],
[
1172,
... | [
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danaparoid"
]
],
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
... | Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Desirudin... |
DB04865 | DB09074 | 4 | 1,362 | [
"DDInter1335",
"DDInter1327"
] | Omacetaxine mepesuccinate | Olaparib | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
4,
24,
1362
]
],
[
[
4,
24,
725
],
[
725,
63,
1362
]
],
[
[
4,
63,
896
],
[
896,
24,
1362
]
],
[
[
4,
24,
1683
],
[
1683,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when ... |
DB00860 | DB09118 | 891 | 1,580 | [
"DDInter1513",
"DDInter1711"
] | Prednisolone | Stiripentol | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
891,
24,
1580
]
],
[
[
891,
24,
283
],
[
283,
63,
1580
]
],
[
[
891,
24,
473
],
[
473,
24,
1580
]
],
[
[
891,
62,
1018
],
[
1018,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and ... |
DB01244 | DB01268 | 762 | 1,151 | [
"DDInter192",
"DDInter1731"
] | Bepridil | Sunitinib | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
762,
25,
1151
]
],
[
[
762,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
762,
21,
28653
],
[
28653,
60,
1151
]
],
[
[
762,
62,
112
],
[
112,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Bepridil",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Sunitinib"
... | Bepridil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Bepridil (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Sunitinib (Compound)
Bepridil may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronida... |
DB00564 | DB11793 | 1,236 | 738 | [
"DDInter293",
"DDInter1297"
] | Carbamazepine | Niraparib | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1236,
24,
738
]
],
[
[
1236,
25,
466
],
[
466,
63,
738
]
],
[
[
1236,
25,
1213
],
[
1213,
24,
738
]
],
[
[
1236,
63,
663
],
[
663,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
"Dar... | Carbamazepine may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Carbamazepine may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a modera... |
DB01023 | DB11691 | 409 | 1,499 | [
"DDInter716",
"DDInter1258"
] | Felodipine | Naldemedine | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
409,
24,
1499
]
],
[
[
409,
63,
723
],
[
723,
24,
1499
]
],
[
[
409,
24,
1478
],
[
1478,
24,
1499
]
],
[
[
409,
23,
578
],
[
578,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaf... |
DB00341 | DB00902 | 1,242 | 104 | [
"DDInter343",
"DDInter1168"
] | Cetirizine | Methdilazine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1242,
24,
104
]
],
[
[
1242,
24,
13
],
[
13,
24,
104
]
],
[
[
1242,
24,
820
],
[
820,
1,
104
]
],
[
[
1242,
24,
537
],
[
537,
40... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB00245 | DB00719 | 357 | 1,219 | [
"DDInter181",
"DDInter149"
] | Benzatropine | Azatadine | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
357,
24,
1219
]
],
[
[
357,
24,
13
],
[
13,
24,
1219
]
],
[
[
357,
24,
830
],
[
830,
1,
1219
]
],
[
[
357,
6,
10104
],
[
10104,
... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Phenindami... |
DB00934 | DB11978 | 413 | 124 | [
"DDInter1124",
"DDInter822"
] | Maprotiline | Glasdegib | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
413,
24,
124
]
],
[
[
413,
62,
112
],
[
112,
23,
124
]
],
[
[
413,
63,
475
],
[
475,
24,
124
]
],
[
[
413,
24,
688
],
[
688,
24,... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Maprotiline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Maprotiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morph... |
DB00745 | DB14568 | 307 | 982 | [
"DDInter1236",
"DDInter1000"
] | Modafinil | Ivosidenib | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
307,
24,
982
]
],
[
[
307,
62,
168
],
[
168,
23,
982
]
],
[
[
307,
63,
1101
],
[
1101,
23,
982
]
],
[
[
307,
23,
976
],
[
976,
2... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Modafinil may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene m... |
DB06704 | DB10316 | 247 | 334 | [
"DDInter952",
"DDInter1248"
] | Iobenguane (I-131) | Mumps virus strain B level jeryl lynn live antigen | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
247,
25,
334
]
],
[
[
247,
7,
6952
],
[
6952,
46,
77
],
[
77,
25,
334
]
],
[
[
247,
18,
7359
],
[
7359,
57,
147
],
[
147,
25,
... | [
[
[
"Iobenguane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Iobenguane",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
"{u} (Gen... | Iobenguane may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Iobenguane (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound) and Idarubicin may lead to a major life threatening interaction when taken with Mumps v... |
DB00476 | DB05351 | 109 | 101 | [
"DDInter608",
"DDInter519"
] | Duloxetine | Dexlansoprazole | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Minor | 0 | [
[
[
109,
23,
101
]
],
[
[
109,
24,
256
],
[
256,
62,
101
]
],
[
[
109,
24,
1479
],
[
1479,
23,
101
]
],
[
[
109,
63,
883
],
[
883,
2... | [
[
[
"Duloxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
],
[
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid... |
DB00748 | DB14509 | 662 | 1,399 | [
"DDInter297",
"DDInter1081"
] | Carbinoxamine | Lithium carbonate | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
662,
24,
1399
]
],
[
[
662,
63,
506
],
[
506,
24,
1399
]
],
[
[
662,
24,
820
],
[
820,
24,
1399
]
],
[
[
662,
35,
100
],
[
100,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorph... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00024 | DB00284 | 818 | 1,647 | [
"DDInter1800",
"DDInter11"
] | Thyrotropin alfa | Acarbose | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Moderate | 1 | [
[
[
818,
24,
1647
]
],
[
[
818,
24,
1645
],
[
1645,
62,
1647
]
],
[
[
818,
24,
1021
],
[
1021,
63,
1647
]
],
[
[
818,
24,
1645
],
[
1645,
... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a minor interaction that can limit clinical effects when taken with Acarbose
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide and... |
DB08880 | DB12159 | 1,510 | 12 | [
"DDInter1771",
"DDInter609"
] | Teriflunomide | Dupilumab | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | Major | 2 | [
[
[
1510,
25,
12
]
],
[
[
1510,
62,
1461
],
[
1461,
23,
12
]
],
[
[
1510,
23,
1114
],
[
1114,
23,
12
]
],
[
[
1510,
64,
599
],
[
599,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dupilumab"
]
],
[
[
"Teriflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Dupilumab
Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc su... |
DB01142 | DB01599 | 1,264 | 1,232 | [
"DDInter593",
"DDInter1523"
] | Doxepin | Probucol | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
1264,
24,
1232
]
],
[
[
1264,
62,
112
],
[
112,
23,
1232
]
],
[
[
1264,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
1264,
24,
927
],
[
927,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Me... | Doxepin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Probucol
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin... |
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